ibuprofen has been researched along with Renal Insufficiency in 21 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Renal Insufficiency: Conditions in which the KIDNEYS perform below the normal level in the ability to remove wastes, concentrate URINE, and maintain ELECTROLYTE BALANCE; BLOOD PRESSURE; and CALCIUM metabolism. Renal insufficiency can be classified by the degree of kidney damage (as measured by the level of PROTEINURIA) and reduction in GLOMERULAR FILTRATION RATE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 7.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| "A 21-month-old boy developed acute renal failure with severe metabolic acidosis after ingestion of ibuprofen 8 g." | 7.69 | Hypocalcemia and hypomagnesemia after ibuprofen overdose. ( al-Harbi, NN; Domrongkitchaiporn, S; Lirenman, DS, 1997) |
| " Oral ibuprofen is associated with lower instance of necrotizing enterocolitis." | 4.95 | Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. ( Keim-Malpass, J; Prescott, S, 2017) |
| " Up to the present day, several cases of severe and sometimes irreversible renal insufficiency have been described in neonates exposed to indomethacin prenatally or in the first days of life for treatment of patent ductus arteriosus (PDA)." | 4.81 | NSAID-induced nephrotoxicity from the fetus to the child. ( Cuzzolin, L; Dal Cerè, M; Fanos, V, 2001) |
| "To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA." | 3.79 | Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013) |
| "Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity." | 3.71 | Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen. ( Henry, MM; Retsch-Bogart, GZ; Scott, CS, 2001) |
| "A 21-month-old boy developed acute renal failure with severe metabolic acidosis after ingestion of ibuprofen 8 g." | 3.69 | Hypocalcemia and hypomagnesemia after ibuprofen overdose. ( al-Harbi, NN; Domrongkitchaiporn, S; Lirenman, DS, 1997) |
| "Ibuprofen appears to be a better choice for PDA closure, with a better side effect profile and efficacy that equals that of indomethacin." | 2.53 | Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration. ( Agarwal, R; Sivanandan, S, 2016) |
| " There is sufficient evidence to consider that ibuprofen, at the currently proposed dosing regimen, has a similar efficacy to indomethacin but is better tolerated by the neonatal kidney when employed for the treatment of established PDA." | 2.44 | Renal effects of ibuprofen for the treatment of patent ductus arteriosus in premature infants. ( Buffat, C; Giniger, RP; Millet, V; Simeoni, U, 2007) |
| "The symptomatic patent ductus arteriosus (sPDA) is common in extremely premature infants (EPI)." | 1.46 | [Digestive and Kidney Complications by indomethacin and ibuprofen in extreme preterm infants with patent ductus arteriosus]. ( Lavín, P; López, M; Miranda, J; Rincón, Y; Salas, R, 2017) |
| "Population pharmacokinetic modelling was performed in nonlinear mixed-effect modelling software (NONMEM version 6." | 1.38 | Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance. ( Allegaert, K; Danhof, M; De Cock, RF; de Hoog, M; Knibbe, CA; Schreuder, MF; Sherwin, CM; van den Anker, JN, 2012) |
| "Ibuprofen use was associated with NF in the setting of primary varicella." | 1.30 | A case-control study of necrotizing fasciitis during primary varicella. ( Alexander, ER; Duchin, JS; Koutsky, LA; Rubens, CE; Zerr, DM, 1999) |
| "Ibuprofen-induced acute renal failure is thought to occur in clinical conditions where maintenance of renal function is prostaglandin-dependent." | 1.29 | Stereoselective disposition of ibuprofen in patients with renal dysfunction. ( Chen, CS; Chen, CY, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (33.33) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Salas, R | 1 |
| Lavín, P | 1 |
| Rincón, Y | 1 |
| Miranda, J | 1 |
| López, M | 1 |
| Raaijmakers, A | 1 |
| Zhang, ZY | 1 |
| Levtchenko, E | 1 |
| Simons, SH | 1 |
| Cauwenberghs, N | 1 |
| Heuvel, LPVD | 1 |
| Jacobs, L | 1 |
| Staessen, JA | 1 |
| Allegaert, K | 2 |
| Park, YA | 1 |
| Harris, G | 1 |
| Degen, DA | 1 |
| Voss, K | 1 |
| Peppas, D | 1 |
| Sivanandan, S | 2 |
| Agarwal, R | 1 |
| Prescott, S | 1 |
| Keim-Malpass, J | 1 |
| Bagnoli, F | 1 |
| Rossetti, A | 1 |
| Casucci, M | 1 |
| Mori, A | 1 |
| De Cock, RF | 1 |
| Schreuder, MF | 1 |
| Sherwin, CM | 1 |
| de Hoog, M | 1 |
| van den Anker, JN | 1 |
| Danhof, M | 1 |
| Knibbe, CA | 1 |
| Heo, MJ | 1 |
| Lee, OS | 1 |
| Lim, SC | 1 |
| Bali, V | 1 |
| Soraisham, AS | 1 |
| Harabor, A | 1 |
| Kamaluddeen, M | 1 |
| Tiker, F | 1 |
| Yildirim, SV | 1 |
| Giniger, RP | 1 |
| Buffat, C | 1 |
| Millet, V | 1 |
| Simeoni, U | 1 |
| Murray, MD | 2 |
| Black, PK | 1 |
| Kuzmik, DD | 1 |
| Haag, KM | 1 |
| Manatunga, AK | 1 |
| Mullin, MA | 1 |
| Hall, SD | 1 |
| Brater, DC | 2 |
| Chen, CY | 1 |
| Chen, CS | 1 |
| al-Harbi, NN | 1 |
| Domrongkitchaiporn, S | 1 |
| Lirenman, DS | 1 |
| Lazaridis, EN | 1 |
| Brizendine, E | 1 |
| Haag, K | 1 |
| Becker, P | 1 |
| Kovesi, TA | 1 |
| Swartz, R | 1 |
| MacDonald, N | 1 |
| Moghal, NE | 1 |
| Hulton, SA | 1 |
| Milford, DV | 1 |
| Zerr, DM | 1 |
| Alexander, ER | 1 |
| Duchin, JS | 1 |
| Koutsky, LA | 1 |
| Rubens, CE | 1 |
| Cuzzolin, L | 1 |
| Dal Cerè, M | 1 |
| Fanos, V | 1 |
| Scott, CS | 1 |
| Retsch-Bogart, GZ | 1 |
| Henry, MM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prematurity as Predictor of Children's Cardiovascular-renal Health (PREMATCH)[NCT02147457] | 180 participants (Actual) | Observational | 2014-10-31 | Completed | |||
| Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022] | Phase 1 | 20 participants (Actual) | Interventional | 2017-06-12 | Completed | ||
| Amikacin Pharmacokinetics to Optimize Dosing Recommendations and Patho(Physiological) Considerations in Neonates With Perinatal Asphyxia Treated With Hypothermia[NCT04867993] | 80 participants (Anticipated) | Interventional | 2018-08-28 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for ibuprofen and Renal Insufficiency
| Article | Year |
|---|---|
Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Decision Making; Drug Administra | 2016 |
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.
Topics: Biomarkers; Cardiac Catheterization; Conservative Treatment; Cyclooxygenase Inhibitors; Ductus Arter | 2017 |
Renal effects of ibuprofen for the treatment of patent ductus arteriosus in premature infants.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Renal Insu | 2007 |
NSAID-induced nephrotoxicity from the fetus to the child.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Ductus Arteriosus, Patent; Female; | 2001 |
2 trials available for ibuprofen and Renal Insufficiency
| Article | Year |
|---|---|
Acute and chronic effects of nonsteroidal antiinflammatory drugs on glomerular filtration rate in elderly patients.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Cross-Over Studies; Female; | 1995 |
The effect of nonsteroidal antiinflammatory drugs on electrolyte homeostasis and blood pressure in young and elderly persons with and without renal insufficiency.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Body Weight; Cross-Over Studies; Humans; Ib | 1997 |
15 other studies available for ibuprofen and Renal Insufficiency
| Article | Year |
|---|---|
[Digestive and Kidney Complications by indomethacin and ibuprofen in extreme preterm infants with patent ductus arteriosus].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis; Female; Humans; I | 2017 |
Ibuprofen exposure in early neonatal life does not affect renal function in young adolescence.
Topics: Child; Child Development; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Inf | 2018 |
Renal recovery in a dialysis-dependent patient with end-stage kidney disease secondary to analgesic nephropathy.
Topics: Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Codeine; Drug Combinations; Humans; Ibuprofen; | 2018 |
Recurrent nephrogenic adenoma: a case report of resolution after treatment with antibiotics and nonsteroidal anti-inflammatory medication.
Topics: Adenoma; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Child; Endoscopy; H | 2013 |
Aminoterminal B-type natriuretic peptide (NT-proBNP) in the therapy of patent ductus arteriosus.
Topics: Biomarkers; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Infant, Extremely | 2010 |
Maturation of the glomerular filtration rate in neonates, as reflected by amikacin clearance.
Topics: Age Factors; Amikacin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; | 2012 |
Comparative evaluation for the use of oral ibuprofen and intravenous indomethacin in Korean infants with patent ductus.
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Comorbidity; Ductus Arteriosus, Paten | 2012 |
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema | 2013 |
Acute renal impairment after oral ibuprofen for medical closure of patent ductus arteriosus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infan | 2007 |
Stereoselective disposition of ibuprofen in patients with renal dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Female; Half-Life; Humans; Ibuprofen; Male; Middle Aged; Renal Insuf | 1994 |
Hypocalcemia and hypomagnesemia after ibuprofen overdose.
Topics: Acidosis; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Humans; Hypocalcemia; Ibuprofen; I | 1997 |
Transient renal failure due to simultaneous ibuprofen and aminoglycoside therapy in children with cystic fibrosis.
Topics: Adolescent; Aminoglycosides; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; | 1998 |
Care in the use of ibuprofen as an antipyretic in children.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Creatini | 1998 |
A case-control study of necrotizing fasciitis during primary varicella.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chickenpox; Child; Child, Preschool; | 1999 |
Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Gentami | 2001 |