ibuprofen has been researched along with Postoperative Complications in 64 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Excerpt | Relevance | Reference |
---|---|---|
"This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 8.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
"Individuals prescribed ibuprofen after trabeculectomy have better postoperative intraocular pressure (IOP) control and a higher chance of bleb survival despite being at a higher risk of scarring." | 8.31 | Oral Ibuprofen is Associated With Reduced Likelihood of Early Bleb Failure After Trabeculectomy in High-Risk Glaucoma Patients. ( Aung, T; Betzler, BK; Boey, PY; Foo, RCM; Ho, CL; Huang, OS; Husain, R; Lamoureux, EL; Low, JR; Man, REK; Perera, SA; Sim, JJL; Wong, TT, 2023) |
"The efficacy of ibuprofen in reducing microvascular thrombosis in a well-established experimental model was studied." | 7.68 | The effect of ibuprofen on microvascular thrombosis in an experimental rabbit model. ( Guinn, OA; Nguyen, T; Rothkopf, DM; Wortham, K, 1993) |
"This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 4.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
"Individuals prescribed ibuprofen after trabeculectomy have better postoperative intraocular pressure (IOP) control and a higher chance of bleb survival despite being at a higher risk of scarring." | 4.31 | Oral Ibuprofen is Associated With Reduced Likelihood of Early Bleb Failure After Trabeculectomy in High-Risk Glaucoma Patients. ( Aung, T; Betzler, BK; Boey, PY; Foo, RCM; Ho, CL; Huang, OS; Husain, R; Lamoureux, EL; Low, JR; Man, REK; Perera, SA; Sim, JJL; Wong, TT, 2023) |
"To investigate the incidence of acute kidney injury after cardiac surgery and its association with mortality in a patient population receiving ibuprofen and gentamicin perioperatively." | 3.80 | Acute kidney injury is independently associated with higher mortality after cardiac surgery. ( Jensen, ME; Kandler, K; Møller, CH; Nilsson, JC; Steinbrüchel, DA, 2014) |
"Diclofenac treatment could result in an increased proportion of patients with anastomotic leakage after colorectal surgery." | 3.78 | Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. ( Gögenur, I; Klein, M; Rosenberg, J, 2012) |
"Treatment of a patent ductus arteriosus with COX-inhibitors such as indomethacin and ibuprofen, increases the risk for bronchopulmonary dysplasia without reducing other complications or death." | 3.75 | [Patent ductus arteriosus in premature infants]. ( Bratlid, D; Farstad, T, 2009) |
"The efficacy of ibuprofen in reducing microvascular thrombosis in a well-established experimental model was studied." | 3.68 | The effect of ibuprofen on microvascular thrombosis in an experimental rabbit model. ( Guinn, OA; Nguyen, T; Rothkopf, DM; Wortham, K, 1993) |
"Pharmacologic alteration of the no-reflow phenomenon was determined based on increased tolerance to ischemia in ibuprofen-treated free flaps." | 3.67 | Beneficial effects of ibuprofen on experimental microvascular free flaps: pharmacologic alteration of the no-reflow phenomenon. ( Douglas, B; Silverman, DG; Song, Y; Weinberg, H, 1987) |
"Finally, diarrhea was recorded in 5 patients of the antibiotic alone group (18." | 2.84 | Antibiotic treatment to prevent postextraction complications: a monocentric, randomized clinical trial. Preliminary outcomes. ( Barone, A; Cinquini, C; Cipolli Panattoni, A; Covani, U; Gabriele, M; Marchionni, FS; Marconcini, S; Toti, P, 2017) |
"Success was defined as no or mild postoperative pain and no use of escape medication." | 2.82 | What is the Effect of No Endodontic Debridement on Postoperative Pain for Symptomatic Teeth with Pulpal Necrosis? ( Beck, M; Drum, M; Fowler, S; Nusstein, J; Reader, A; Sebastian, R, 2016) |
" Intravenous ibuprofen administered at induction of anesthesia may be a safe and efficacious option for postoperative tonsillectomy pain." | 2.79 | A multicenter, randomized, double-blind placebo-controlled, single dose trial of the safety and efficacy of intravenous ibuprofen for treatment of pain in pediatric patients undergoing tonsillectomy. ( Bendel, LP; Glover, CD; McCarthy, DL; Moss, JR; Watcha, MF; Witham, SL, 2014) |
"60 Miller class I and II gingival recessions (GR) (≥ 3 mm in depth) were treated with the coronally advanced flap plus extraoral de-epithelialized free gingival graft (FGG)." | 2.79 | Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial. ( Mazzotti, C; Mele, M; Montebugnoli, L; Mounssif, I; Sangiorgi, M; Stefanini, M; Zucchelli, G, 2014) |
"The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening." | 2.77 | Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. ( Aznar-Arasa, L; Figueiredo, R; Gay-Escoda, C; Harutunian, K; Valmaseda-Castellón, E, 2012) |
"The profiles of postoperative pain in the two groups were similar from the first postoperative day, but Ibumetin was better pain reliever on the day of surgery." | 2.67 | Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon). ( Anzén, B; Lysell, L, 1992) |
"In the 22 patients with heterotopic ossification this was demonstrated in all but eight within 6 weeks, and in only three did it appear later than 3 months postoperatively." | 2.66 | Effect of ibuprofen on heterotopic ossification after hip replacement. ( Elmstedt, E; Lindholm, TS; Nilsson, OS; Törnkvist, H, 1985) |
"Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis." | 2.58 | Surgery, neuroinflammation and cognitive impairment. ( Alam, A; Hana, Z; Jin, Z; Ma, D; Suen, KC, 2018) |
"Severe scar tissue adhesion, known as epidural fibrosis, is a common cause of failed back surgery syndrome." | 1.43 | Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis. ( Chang, CJ; Chen, MH; Lin, CY; Liu, TY; Peng, HH; Sun, JS, 2016) |
"Orbital cellulitis is a rarely reported but is potentially vision- and life-threatening complication after strabismus surgery." | 1.33 | Orbital cellulitis after strabismus surgery. ( Kose, S; Palamar, M; Uretmen, O, 2005) |
" Thereafter, rabbits received further dosing every 6 hr to complete a total 10-dose regimen." | 1.27 | Ibuprofen inhibition of postsurgical adhesion formation: a time and dose response biochemical evaluation in rabbits. ( diZerega, GS; Nakamura, RM; Nishimura, K, 1984) |
"Ibuprofen appeared to inhibit the formation of significant adhesions as compared with adhesion formation in untreated control animals, and the results seemed as effective as in the dexamethasone-treated animals." | 1.26 | Prevention of postoperative adhesions in rabbits with ibuprofen, a nonsteroidal anti-inflammatory agent. ( Kontopoulos, V; Siegler, AM; Wang, CF, 1980) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 19 (29.69) | 18.7374 |
1990's | 8 (12.50) | 18.2507 |
2000's | 13 (20.31) | 29.6817 |
2010's | 22 (34.38) | 24.3611 |
2020's | 2 (3.13) | 2.80 |
Authors | Studies |
---|---|
Mittal, A | 1 |
Tamer, P | 1 |
Shah, I | 1 |
Cortes, A | 1 |
Hinman, AD | 1 |
Sim, JJL | 1 |
Man, REK | 1 |
Foo, RCM | 1 |
Huang, OS | 1 |
Betzler, BK | 1 |
Husain, R | 1 |
Ho, CL | 1 |
Boey, PY | 1 |
Perera, SA | 1 |
Low, JR | 1 |
Aung, T | 1 |
Lamoureux, EL | 1 |
Wong, TT | 1 |
Barone, A | 1 |
Marchionni, FS | 1 |
Cinquini, C | 1 |
Cipolli Panattoni, A | 1 |
Toti, P | 1 |
Marconcini, S | 1 |
Covani, U | 1 |
Gabriele, M | 1 |
Cole, WC | 1 |
Mayo, JS | 1 |
Yheulon, CG | 1 |
Uber, AM | 1 |
Montez-Rath, ME | 1 |
Kwiatkowski, DM | 1 |
Krawczeski, CD | 1 |
Sutherland, SM | 1 |
Alam, A | 1 |
Hana, Z | 1 |
Jin, Z | 1 |
Suen, KC | 1 |
Ma, D | 1 |
El-Salamouni, NS | 1 |
Gowayed, MA | 1 |
Labib, GS | 1 |
Eslampour, A | 1 |
Malaekeh-Nikouei, B | 1 |
Abrishami, M | 1 |
Bayani, R | 1 |
Jiang, S | 1 |
Liu, S | 1 |
Fan, C | 1 |
Breschan, C | 1 |
Jost, R | 1 |
Stettner, H | 1 |
Feigl, G | 1 |
Semmelrock, S | 1 |
Graf, G | 1 |
Likar, R | 1 |
Moss, JR | 1 |
Watcha, MF | 1 |
Bendel, LP | 1 |
McCarthy, DL | 1 |
Witham, SL | 1 |
Glover, CD | 1 |
Zucchelli, G | 1 |
Mounssif, I | 1 |
Mazzotti, C | 1 |
Montebugnoli, L | 1 |
Sangiorgi, M | 1 |
Mele, M | 1 |
Stefanini, M | 1 |
Xu, Z | 1 |
Dong, Y | 1 |
Wang, H | 1 |
Culley, DJ | 1 |
Marcantonio, ER | 1 |
Crosby, G | 1 |
Tanzi, RE | 1 |
Zhang, Y | 1 |
Xie, Z | 1 |
Kandler, K | 1 |
Jensen, ME | 1 |
Nilsson, JC | 1 |
Møller, CH | 1 |
Steinbrüchel, DA | 1 |
Sebastian, R | 1 |
Drum, M | 1 |
Reader, A | 5 |
Nusstein, J | 1 |
Fowler, S | 1 |
Beck, M | 5 |
Lin, CY | 1 |
Peng, HH | 1 |
Chen, MH | 2 |
Sun, JS | 1 |
Chang, CJ | 1 |
Liu, TY | 1 |
Haw, MP | 1 |
Fry, R | 1 |
Ring, P | 1 |
Bratlid, D | 1 |
Farstad, T | 1 |
Pham, TM | 1 |
Hagman, B | 1 |
Codita, A | 1 |
Van Loo, PL | 1 |
Strömmer, L | 1 |
Baumans, V | 1 |
Bauer, DF | 1 |
Waters, AM | 1 |
Tubbs, RS | 1 |
Rozzelle, CJ | 1 |
Wellons, JC | 1 |
Blount, JP | 1 |
Oakes, WJ | 1 |
Baygin, O | 1 |
Tuzuner, T | 1 |
Isik, B | 1 |
Kusgoz, A | 1 |
Tanriver, M | 1 |
Aznar-Arasa, L | 1 |
Harutunian, K | 1 |
Figueiredo, R | 1 |
Valmaseda-Castellón, E | 1 |
Gay-Escoda, C | 1 |
Sanz-Moliner, JD | 1 |
Nart, J | 1 |
Cohen, RE | 1 |
Ciancio, SG | 1 |
Mitchell, A | 1 |
McCrea, P | 1 |
Inglis, K | 1 |
Porter, G | 1 |
Klein, M | 1 |
Gögenur, I | 1 |
Rosenberg, J | 1 |
Nusstein, JM | 1 |
Muensterer, OJ | 1 |
Schenk, DS | 1 |
Praun, M | 1 |
Boehm, R | 1 |
Till, H | 1 |
Revol, P | 1 |
Gleizal, A | 1 |
Kraft, T | 1 |
Breton, P | 1 |
Freidel, M | 1 |
Bouletreau, P | 1 |
Cheruku, KK | 1 |
Ghani, A | 1 |
Ahmad, F | 1 |
Pappas, P | 1 |
Silverman, PR | 1 |
Zelinger, A | 1 |
Silver, MA | 1 |
Mackey, JE | 1 |
Anbar, RD | 1 |
Jaillard, S | 1 |
Larrue, B | 1 |
Rakza, T | 1 |
Magnenant, E | 1 |
Warembourg, H | 1 |
Storme, L | 1 |
Palamar, M | 1 |
Uretmen, O | 1 |
Kose, S | 1 |
Khosa, JK | 1 |
Kimble, RM | 1 |
Luciano, AA | 1 |
Hauser, KS | 1 |
Benda, J | 1 |
Nishimura, K | 2 |
Shimanuki, T | 1 |
diZerega, GS | 2 |
Nakamura, RM | 1 |
De Leon, FD | 2 |
Toledo, AA | 1 |
Sanfilippo, JS | 1 |
Yussman, MA | 1 |
Gloviczki, P | 1 |
Hollier, LH | 1 |
Dewanjee, MK | 1 |
Trastek, VF | 1 |
Hoffman, EA | 1 |
Kaye, MP | 1 |
O'Brien, WF | 1 |
Drake, TS | 1 |
Bibro, MC | 1 |
Bateman, BG | 1 |
Nunley, WC | 1 |
Kitchin, JD | 1 |
Carson, S | 1 |
Demling, R | 1 |
Esquivel, C | 1 |
Talken, L | 1 |
Tillman, P | 1 |
Siegler, AM | 1 |
Kontopoulos, V | 1 |
Wang, CF | 1 |
Gross, SA | 1 |
von Noorden, GK | 1 |
Jones, DB | 1 |
Nguyen, T | 1 |
Guinn, OA | 1 |
Wortham, K | 1 |
Rothkopf, DM | 1 |
St Charles, CS | 1 |
Matt, BH | 1 |
Hamilton, MM | 1 |
Katz, BP | 1 |
Walter, K | 1 |
Dilger, C | 1 |
Koorevaar, CT | 1 |
Hu, HP | 1 |
Lemmens, A | 1 |
van Kampen, A | 1 |
Nist, E | 1 |
Pickenpaugh, L | 1 |
Meyers, WJ | 1 |
Peterson, LJ | 1 |
Henry, M | 1 |
Mello, MB | 1 |
Chekin, MR | 1 |
Lysell, L | 1 |
Anzén, B | 1 |
Maunuksela, EL | 1 |
Ryhänen, P | 1 |
Janhunen, L | 1 |
Campbell, WI | 1 |
Odom, J | 1 |
Hudkins, P | 1 |
Vijayakumar, R | 1 |
Heine, MW | 1 |
Darsow, F | 1 |
Witt, M | 1 |
Sodemann, B | 1 |
Persson, PE | 1 |
Nilsson, OS | 2 |
Thayer, ML | 1 |
Bubrick, MP | 1 |
Jacobs, DM | 1 |
Frykman, S | 1 |
Nirankari, VS | 1 |
Karesh, JW | 1 |
Jarrett, JC | 1 |
Dawood, MY | 1 |
Douglas, B | 1 |
Weinberg, H | 1 |
Song, Y | 1 |
Silverman, DG | 1 |
Elmstedt, E | 1 |
Lindholm, TS | 1 |
Törnkvist, H | 1 |
Vander Salm, TJ | 1 |
Okike, ON | 1 |
Marsicano, TH | 1 |
Compton, C | 1 |
Espinoza, E | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients[NCT04701801] | 200 participants (Actual) | Observational [Patient Registry] | 2020-10-21 | Completed | |||
Normative Data for the Quick Mild Cognitive Impairment-Taiwan Version (Qmci- TQ) in a Taiwanese Sample[NCT04598178] | 30 participants (Actual) | Observational | 2020-08-04 | Completed | |||
Efficacy of Perioperative Goal-directed Fluid Therapy in Preventing Cerebral Desaturation and Postoperative Cognitive Dysfunction After Beach Chair Position Shoulder Surgery[NCT03963063] | 70 participants (Actual) | Interventional | 2019-06-27 | Completed | |||
Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery[NCT05474872] | 100 participants (Anticipated) | Observational | 2022-07-15 | Recruiting | |||
[NCT02291705] | Phase 4 | 40 participants (Actual) | Interventional | 2012-01-31 | Completed | ||
Efficacy of Adding Dexmedetomidine Versus Ibuprofen as an Adjuvant to Intraperitoneal Bupivacaine for Pain Control After Laparoscopic Gynecological Procedures: a Double-blind Randomized Comparative Study[NCT06046105] | Phase 2/Phase 3 | 180 participants (Anticipated) | Interventional | 2023-09-15 | Not yet recruiting | ||
Analysis of the Complications in Palatal Graft Harvesting With the UPV/EHU Technique vs. Single Incision Technique.[NCT06114394] | 70 participants (Anticipated) | Interventional | 2023-10-30 | Not yet recruiting | |||
A Multicenter Randomized Controlled Study Comparing Connective Tissue Graft With Collagen Matrix to Re-establish Convexity at the Buccal Aspect of Single Dental Implants[NCT04210596] | 60 participants (Actual) | Interventional | 2019-09-01 | Active, not recruiting | |||
Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication : A Randomized Clinical Trial.[NCT05021809] | Phase 4 | 60 participants (Anticipated) | Interventional | 2021-07-25 | Recruiting | ||
Comparison of Pre-emptive Ibuprofen, Acetaminophen, and Placebo Administration in Reducing Local Anesthesia Injection Pain and Post-operative Pain in Primary Tooth Extraction. A Clinical Study[NCT03786029] | Phase 2/Phase 3 | 66 participants (Actual) | Interventional | 2019-04-01 | Completed | ||
Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone[NCT02029235] | Phase 4 | 72 participants (Actual) | Interventional | 2015-02-10 | Terminated (stopped due to Early termination due to slower than anticipated recruitment.) | ||
Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652] | 502 participants (Actual) | Observational [Patient Registry] | 2015-01-01 | Completed | |||
Effect on Initial Endodontic Treatment on Postoperative Pain in Symptomatic Teeth With Pulpal Necrosis[NCT01870973] | 108 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
Colchicine for the Prevention of Atrial Fibrillation Recurrence After Electrical Cardioversion of Persistent Atrial Fibrillation.[NCT02582190] | Phase 3 | 0 participants (Actual) | Interventional | 2017-12-02 | Withdrawn (stopped due to Investigational Medicinal Product Supplies) | ||
Postoperative Ibuprofen and the Risk of Bleeding After Tonsillectomy With or Without Adenoidectomy[NCT01605903] | Phase 2 | 741 participants (Actual) | Interventional | 2012-05-03 | Completed | ||
Comparing Narcotics With Non-steroidal Anti-inflammatory Drugs (NSAIDS) Post-operatively in Pediatric Patients Undergoing Adenotonsillectomy[NCT02296840] | Phase 4 | 45 participants (Actual) | Interventional | 2014-11-30 | Terminated | ||
Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057] | Phase 1 | 0 participants (Actual) | Interventional | 2018-09-30 | Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured) | ||
Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial.[NCT03033147] | 72 participants (Actual) | Interventional | 2019-10-18 | Completed | |||
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial[NCT03007342] | 78 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
"Subjects asked to fill out a patient diary recording their pain intensity level (on 100mm Visual Analog Scale) prior to taking study medication every 4 hours.~The daily average pain intensity levels are reported as a score on a scale of 0-100, with higher score meaning worse outcome.~The daily average pain levels were assessed daily for 1 week post-operatively, then compared between the 2 groups using a two-group Student's t-test." (NCT02029235)
Timeframe: 1 week post-operatively
Intervention | score on a scale (0-100, higher = worse) (Mean) | ||||||
---|---|---|---|---|---|---|---|
Daily average pain intensity level on PostOp Day 1 | Daily average pain intensity level on PostOp Day 2 | Daily average pain intensity level on PostOp Day 3 | Daily average pain intensity levelon PostOp Day 4 | Daily average pain intensity level on PostOp Day 5 | Daily average pain intensity level on PostOp Day 6 | Daily average pain intensity level on PostOp Day 7 | |
Acetaminophen/Hydrocodone (AH) Group | 24.07 | 30.16 | 22.11 | 18.53 | 16.61 | 13.58 | 13.00 |
Acetaminophen/Ibuprofen (AIBU) Group | 22.17 | 22.22 | 15.67 | 13.17 | 14.03 | 13.44 | 12.67 |
"Subjects asked to fill out a patient diary recording their pain relief (on a Likert scale) one hour after taking study medication every 4 hours.~Daily average pain relief scores are reported as a score on a scale of 0-3, with higher score meaning better outcome.~The daily average pain relief scores were assessed daily for 1 week post-operatively, then compared using generalized linear mixed-effects models" (NCT02029235)
Timeframe: 1 week postoperatively
Intervention | score on a scale (0-3, higher = better) (Mean) | ||||||
---|---|---|---|---|---|---|---|
Daily average pain relief on PostOp Day 1 | Daily average pain relief on PostOp Day 2 | Daily average pain relief on PostOp Day 3 | Daily average pain relief on PostOp Day 4 | Daily average pain relief on PostOp Day 5 | Daily average pain relief on PostOp Day 6 | Daily average pain relief on PostOp Day 7 | |
Acetaminophen/Hydrocodone (AH) Group | 1.53 | 1.76 | 2.33 | 2.46 | 2.54 | 2.84 | 2.88 |
Acetaminophen/Ibuprofen (AIBU) Group | 1.84 | 2.27 | 2.63 | 2.91 | 2.88 | 2.87 | 2.96 |
"pain measurement as assessed on a visual analog scale and pain medication usage~definition of success = no or mild pain as analyzed on VAS scale and no narcotic use; analyzed by logistic regression~VAS scale is 0 to 170 mm with the higher numbers indicating more pain and less success." (NCT01870973)
Timeframe: each day for 5 days
Intervention | percentage of participants (Number) |
---|---|
Root Canal Treatment | 52 |
no Root Canal Treatment | 43 |
Postoperative hemorrhage is defined as any history of bleeding occurring within the 14 day postoperative period. Hemorrhage will be stratified into 3 levels of severity. Level 1: includes children with a history of postoperative bleeding evaluated and/or treated by a physician in the emergency room, inpatient unit or operating room; Level 2: children requiring inpatient admission for postoperative bleeding regardless of the need for operative intervention; Level 3: children requiring inpatient admission and return to the operating room for control of post-tonsillectomy hemorrhage. (NCT01605903)
Timeframe: Data about post-tonsillectomy bleeding will be obtained after the end of a 14-day postoperative period.
Intervention | Participants (Count of Participants) |
---|---|
Treatment With Ibuprofen | 10 |
Treatment With Acetaminophen | 4 |
Using the Faces Pain Scale, the pediatric patient will indicate his/her pain level at scheduled intervals (7 times per day) for 14 days post-surgery.The Faces Pain Scale Revised is a dimensionless 10 point likert scale used to assess self-reported pain intensity on a scale from 0 (no pain) to 10 (most pain you can imagine). Greater pain scores are indicative of more severe pain. For this analysis, participant pain scores were summed and the mean per group was calculated. Total summed scores could range from 0 to 980. (NCT02296840)
Timeframe: 2 weeks after surgery
Intervention | units on a scale (Mean) |
---|---|
Ibuprofen | 158.95 |
Hydrocodone-acetaminophen | 219.94 |
The occurrence of post-operative bleeding at the surgical site for each participant will be assessed by review of the participant's study records and clinical records and by questioning the caregiver in follow-up. If postoperative bleeding has occurred, details of the episode of bleeding will also be obtained (requirement for surgical intervention, observation at home, or observation at the hospital). (NCT02296840)
Timeframe: 2 weeks after surgery
Intervention | Participants (Count of Participants) |
---|---|
Ibuprofen | 2 |
Hydrocodone-acetaminophen | 0 |
4 reviews available for ibuprofen and Postoperative Complications
Article | Year |
---|---|
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
[Research progress of mechanism and prevention of peritendinous adhesions].
Topics: Animals; Anti-Inflammatory Agents; Biocompatible Materials; Genetic Therapy; Humans; Hyaluronic Acid | 2013 |
Surgical Intervention in Preterm Neonates with Patent Ductus Arteriosus.
Topics: Bronchopulmonary Dysplasia; Combined Modality Therapy; Cyclooxygenase Inhibitors; Ductus Arteriosus, | 2016 |
High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Barrett Esophagus; Combined Modality Therapy; C | 2004 |
19 trials available for ibuprofen and Postoperative Complications
Article | Year |
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Antibiotic treatment to prevent postextraction complications: a monocentric, randomized clinical trial. Preliminary outcomes.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Inflammatory | 2017 |
Efficacy of extended-release oral diclofenac in postoperative pain management after photorefractive keratectomy.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Astigmatism | 2013 |
A multicenter, randomized, double-blind placebo-controlled, single dose trial of the safety and efficacy of intravenous ibuprofen for treatment of pain in pediatric patients undergoing tonsillectomy.
Topics: Adolescent; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Method; | 2014 |
Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial.
Topics: Alveolar Process; Analgesics, Non-Narcotic; Double-Blind Method; Esthetics, Dental; Follow-Up Studie | 2014 |
Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial.
Topics: Alveolar Process; Analgesics, Non-Narcotic; Double-Blind Method; Esthetics, Dental; Follow-Up Studie | 2014 |
Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial.
Topics: Alveolar Process; Analgesics, Non-Narcotic; Double-Blind Method; Esthetics, Dental; Follow-Up Studie | 2014 |
Does the dimension of the graft influence patient morbidity and root coverage outcomes? A randomized controlled clinical trial.
Topics: Alveolar Process; Analgesics, Non-Narcotic; Double-Blind Method; Esthetics, Dental; Follow-Up Studie | 2014 |
What is the Effect of No Endodontic Debridement on Postoperative Pain for Symptomatic Teeth with Pulpal Necrosis?
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Debridement | 2016 |
Comparison of pre-emptive ibuprofen, paracetamol, and placebo administration in reducing post-operative pain in primary tooth extraction.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; | 2011 |
Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female; | 2012 |
The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans.
Topics: Analgesics, Non-Narcotic; Chronic Periodontitis; Color; Combined Modality Therapy; Edema; Female; Hu | 2013 |
A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Breast Neoplasms; Ca | 2012 |
Efficacy of nonsteroidal anti-inflammatory medications for prevention of atrial fibrillation following coronary artery bypass graft surgery.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Atrial Fibrillation; Coronary Artery Bypass; Female; | 2004 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
A comparison of ibuprofen versus acetaminophen with codeine in the young tonsillectomy patient.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal | 1997 |
No effective prophylaxis of heterotopic ossification with short-term ibuprofen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, | 1999 |
Effect of apical trephination on postoperative pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anti-Infla | 2001 |
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varianc | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon).
Topics: Acetaminophen; Adolescent; Adult; Codeine; Drug Combinations; Edema; Female; Humans; Ibuprofen; Male | 1992 |
Efficacy of rectal ibuprofen in controlling postoperative pain in children.
Topics: Administration, Rectal; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; | 1992 |
[Treatment of postoperative synovitis following meniscus operations with ibuprofen].
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen; Knee Injuries; Menisci, Tibial; Po | 1988 |
Effect of ibuprofen on heterotopic ossification after hip replacement.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hip Prosthesis; Humans; Ibuprofen; Male | 1985 |
41 other studies available for ibuprofen and Postoperative Complications
Article | Year |
---|---|
Postoperative Acute Kidney Injury With Dual NSAID Use After Outpatient Primary Total Joint Arthroplasty.
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Aspiri | 2022 |
Oral Ibuprofen is Associated With Reduced Likelihood of Early Bleb Failure After Trabeculectomy in High-Risk Glaucoma Patients.
Topics: Aged; Cicatrix; Female; Glaucoma; Humans; Ibuprofen; Intraocular Pressure; Male; Middle Aged; Ocular | 2023 |
Pericarditis as a Result of Pneumomediastinum after Uncomplicated Laparoscopic Totally Extraperitoneal Inguinal Hernia Repair.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Contrast Media; Diagnosis, Differential; Electrocard | 2017 |
Nephrotoxin exposure and acute kidney injury in critically ill children undergoing congenital cardiac surgery.
Topics: Acute Kidney Injury; Adolescent; Aspirin; Cardiac Surgical Procedures; Child; Child, Preschool; Crit | 2018 |
Controlled release Ibu-cryobarriers for the prevention of post-operative adhesions: In-vitro/in-vivo comparative study.
Topics: Abdominal Wall; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cecum; Cryogels; Delayed-Action Pr | 2019 |
Ultrasound-guided rectus sheath block for pyloromyotomy in infants: a retrospective analysis of a case series.
Topics: Analgesics, Opioid; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Female; Fentanyl; | 2013 |
Peripheral surgical wounding and age-dependent neuroinflammation in mice.
Topics: Age Factors; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cognition; Cognition Disorder | 2014 |
Acute kidney injury is independently associated with higher mortality after cardiac surgery.
Topics: Acute Kidney Injury; Aged; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Bacterial Agents; Ca | 2014 |
Ibuprofen-conjugated hyaluronate/polygalacturonic acid hydrogel for the prevention of epidural fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Drug Carriers; Epidural Space; Hydrogel, | 2016 |
Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block.
Topics: Acetaminophen; Acetazolamide; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents | 2008 |
[Patent ductus arteriosus in premature infants].
Topics: Bronchopulmonary Dysplasia; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Hemodynamics; Huma | 2009 |
Housing environment influences the need for pain relief during post-operative recovery in mice.
Topics: Analgesics, Non-Narcotic; Anesthetics, Inhalation; Animals; Behavior, Animal; Body Weight; Disease M | 2010 |
Safety and utility of scheduled nonnarcotic analgesic medications in children undergoing craniotomy for brain tumor.
Topics: Adolescent; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; B | 2010 |
Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data.
Topics: Aged; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colorectal Neoplasm | 2012 |
Effect of drainage upon access on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2002 |
Postpericardiotomy syndrome after minimally invasive pectus excavatum repair unresponsive to nonsteroidal anti-inflammatory treatment.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Funnel Chest; Humans; Ibuprofen; Male; Postoper | 2003 |
[Brain abscess and diffuse cervico-facial cellulitis: complication after mandibular third molar extraction].
Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain Abscess; Cellulitis; Dr | 2003 |
Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants.
Topics: Combined Modality Therapy; Ductus Arteriosus, Patent; Enteral Nutrition; Female; Gestational Age; Hu | 2006 |
Orbital cellulitis after strabismus surgery.
Topics: Adolescent; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cefuroxime; Cellulitis; | 2005 |
Bleeding postoperatively from a Meckel diverticulum, secondary to NSAIDs: a cautionary note.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Gastric Mucosa; Gastrointestinal Hemorrhage; Hernia, | 2007 |
Evaluation of commonly used adjuvants in the prevention of postoperative adhesions.
Topics: Animals; Dexamethasone; Dextrans; Drug Evaluation; Female; Ibuprofen; Infertility, Female; Inflammat | 1983 |
Ibuprofen in the prevention of experimentally induced postoperative adhesions.
Topics: Abdomen; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Dose-Response Relationship, Drug; F | 1984 |
Ibuprofen inhibition of postsurgical adhesion formation: a time and dose response biochemical evaluation in rabbits.
Topics: Animals; Collagen; Dose-Response Relationship, Drug; Female; Glycosaminoglycans; Ibuprofen; Postoper | 1984 |
The prevention of adhesion formation by nonsteroidal antiinflammatory drugs: an animal study comparing ibuprofen and indomethacin.
Topics: Animals; Fallopian Tube Diseases; Fallopian Tubes; Female; Guinea Pigs; Ibuprofen; Indomethacin; Pos | 1984 |
Experimental replacement of the inferior vena cava: factors affecting patency.
Topics: Animals; Arteriovenous Shunt, Surgical; Blood Vessel Prosthesis; Dogs; Female; Heparin; Ibuprofen; J | 1984 |
The use of ibuprofen and dexamethasone in the prevention of postoperative adhesion formation.
Topics: Adnexa Uteri; Animals; Castration; Cyclooxygenase Inhibitors; Dexamethasone; Female; Ibuprofen; Infe | 1982 |
Prevention of postoperative peritoneal adhesions with ibuprofen.
Topics: Animals; Drug Evaluation, Preclinical; Female; Ibuprofen; Peritoneal Diseases; Postoperative Complic | 1982 |
Testing and treatment of arterial graft thrombosis.
Topics: Animals; Arteries; Aspirin; Blood Vessel Prosthesis; Constriction, Pathologic; Disease Models, Anima | 1981 |
Prevention of postoperative adhesions in rabbits with ibuprofen, a nonsteroidal anti-inflammatory agent.
Topics: Animals; Dexamethasone; Female; Ibuprofen; Peritoneum; Postoperative Complications; Rabbits; Tissue | 1980 |
Necrotizing scleritis and transient myopia following strabismus surgery.
Topics: Female; Glucocorticoids; Humans; Ibuprofen; Middle Aged; Myopia; Necrosis; Postoperative Complicatio | 1993 |
The effect of ibuprofen on microvascular thrombosis in an experimental rabbit model.
Topics: Anastomosis, Surgical; Animals; Femoral Artery; Ibuprofen; Injections, Subcutaneous; Microcirculatio | 1993 |
Ibuprofen in human milk.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Female; Humans | 1997 |
[Clinical evaluation of the efficiency of Ibuprofen (400 mg) in inflammatory dental processes].
Topics: Adolescent; Adult; Drug Therapy, Combination; Face; Female; Humans; Ibuprofen; Lincomycin; Male; Mid | 1978 |
Analgesic side effects and minor surgery: which analgesic for minor and day-case surgery?
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics; Codeine; Drug Combinations; Female | 1990 |
Orally and parenterally administered ibuprofen for postoperative adhesion prevention.
Topics: Administration, Oral; Animals; Dextrans; Drug Therapy, Combination; Fallopian Tubes; Female; Ibuprof | 1986 |
Prevention of heterotopic ossification by nonsteroid antiinflammatory drugs after total hip arthroplasty.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Hip Joint; Hip Prosthesis; Humans; Ibuprofen; | 1988 |
Effects of ibuprofen on postoperative bowel motility and propulsion.
Topics: Animals; Colon; Dogs; Gastrointestinal Motility; Ibuprofen; Ileum; Intestinal Obstruction; Intestine | 1988 |
Cystoid macular edema following penetrating keratoplasty: incidence and prognosis.
Topics: Adrenal Cortex Hormones; Corneal Transplantation; Humans; Ibuprofen; Macular Edema; Postoperative Co | 1986 |
Adhesion formation and uterine tube healing in the rabbit: a controlled study of the effect of ibuprofen and flurbiprofen.
Topics: Animals; Fallopian Tube Diseases; Fallopian Tubes; Female; Flurbiprofen; Ibuprofen; Postoperative Ca | 1986 |
Beneficial effects of ibuprofen on experimental microvascular free flaps: pharmacologic alteration of the no-reflow phenomenon.
Topics: Animals; Female; Fluorescein; Fluoresceins; Half-Life; Hemodynamics; Ibuprofen; Ischemia; Microcircu | 1987 |
Prevention of postoperative pericardial adhesions. An animal study.
Topics: Animals; Cardiac Surgical Procedures; Dogs; Drug Evaluation, Preclinical; Heart Diseases; Ibuprofen; | 1986 |