ibuprofen has been researched along with Peptic Ulcer Perforation in 5 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Peptic Ulcer Perforation: Penetration of a PEPTIC ULCER through the wall of DUODENUM or STOMACH allowing the leakage of luminal contents into the PERITONEAL CAVITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We analysed pooled data from two identical double-blind, randomized, 12-week endoscopy studies which compared the gastroduodenal toxicity of placebo (n=371), rofecoxib 25 mg (n=390), rofecoxib 50 mg (n=379), and ibuprofen 2400 mg daily (n=376) in patients with osteoarthritis." | 5.09 | Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials. ( Bolognese, JA; Harper, SE; Hawkey, CJ; Laine, L; Mortensen, E; Quan, HU, 2001) |
| "Over a 6-month period, two patients presented to a community hospital emergency department with perforated gastric ulcers as the result of recreational misuse of over-the-counter ibuprofen-codeine preparations." | 3.74 | Nurofen Plus misuse: an emerging cause of perforated gastric ulcer. ( Dutch, MJ, 2008) |
| "A 3-year-old Chow Chow was examined because of a 2-week history of vomiting and anorexia after administration of 200 mg of ibuprofen." | 3.68 | Gastric perforation associated with administration of ibuprofen in a dog. ( Fingland, RB; Godshalk, CP; Roush, JK; Sikkema, D; Vorhies, MW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hunt, RH | 1 |
| Harper, S | 1 |
| Watson, DJ | 1 |
| Yu, C | 1 |
| Quan, H | 1 |
| Lee, M | 1 |
| Evans, JK | 1 |
| Oxenius, B | 1 |
| Dutch, MJ | 1 |
| Smith, KJ | 1 |
| Taylor, DH | 1 |
| Hawkey, CJ | 1 |
| Laine, L | 1 |
| Harper, SE | 1 |
| Quan, HU | 1 |
| Bolognese, JA | 1 |
| Mortensen, E | 1 |
| Godshalk, CP | 1 |
| Roush, JK | 1 |
| Fingland, RB | 1 |
| Sikkema, D | 1 |
| Vorhies, MW | 1 |
2 trials available for ibuprofen and Peptic Ulcer Perforation
| Article | Year |
|---|---|
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloo | 2003 |
Influence of risk factors on endoscopic and clinical ulcers in patients taking rofecoxib or ibuprofen in two randomized controlled trials.
Topics: Aged; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; | 2001 |
3 other studies available for ibuprofen and Peptic Ulcer Perforation
| Article | Year |
|---|---|
Nurofen Plus misuse: an emerging cause of perforated gastric ulcer.
Topics: Abdominal Pain; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Drug Co | 2008 |
Another case of gastric perforation associated with administration of ibuprofen in a dog.
Topics: Animals; Dog Diseases; Dogs; Ibuprofen; Male; Peptic Ulcer Perforation; Stomach Ulcer | 1993 |
Gastric perforation associated with administration of ibuprofen in a dog.
Topics: Animals; Anorexia; Dog Diseases; Dogs; Duodenostomy; Female; Gastrostomy; Ibuprofen; Peptic Ulcer Pe | 1992 |