ibuprofen has been researched along with Osteoarthritis, Knee in 47 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials." | 9.41 | Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials. ( Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W, 2021) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 9.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "To investigate the effect of 12 weeks of strength training in combination with a nonsteroidal anti-inflammatory drug (NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA), strength (primary outcome parameters), and function, power, pain, and satellite cell number (secondary outcome parameters) in patients with knee osteoarthritis (OA)." | 9.15 | Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. ( Aagaard, P; Beyer, N; Hansen, M; Holm, L; Kjaer, M; Mackey, AL; Petersen, SG, 2011) |
| "To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare." | 9.12 | A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip. ( De Clerck, L; De Keyser, F; Geusens, P; Hauzeur, JP; Luyten, FP; Malaise, M; Mathy, L; Raeman, F; Van den Bosch, F; Vander Mijnsbrugge, D; Westhovens, R, 2007) |
| " Patients with flare-up of their osteoarthritis disease process exhibit enhanced levels of markers of joint inflammation and cartilage collagen breakdown, which were markedly decreased by nimesulide but not by ibuprofen." | 9.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "Our data suggest that acetaminophen and ibuprofen are comparably effective in treating knee OA pain, even when the pain is severe." | 9.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| "To determine individual responses to ibuprofen gel or capsaicin cream for painful, radiographic knee OA using a series of n-of-1 trials." | 5.41 | Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials. ( Doherty, M; Fernandes, G; Persson, MSM; Sarmanova, A; Stocks, J; Walsh, DA; Zhang, W, 2021) |
| "An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain." | 5.24 | Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. ( Doherty, M; Hussain, S; McWilliams, D; Papou, A; Zhang, W, 2017) |
| "Ibuprofen is a non-selective cyclo-oxygenase (COX)-1/COX-2 inhibitor used to treat pain conditions and inflammation." | 5.16 | Characteristics and clinical implications of the pharmacokinetic profile of ibuprofen in patients with knee osteoarthritis. ( Corigliano, A; De Sarro, G; Falcone, D; Galasso, O; Gallelli, L; Gasparini, G; Longo, P; Palleria, C; Saccà, S; Savino, R; Southworth, SR; Terracciano, R; Urzino, A, 2012) |
| "Ibuprofen/paracetamol combination analgesia, at non-prescription doses, confers modest short-term benefits for knee pain/osteoarthritis." | 5.15 | A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain. ( Aspley, S; Doherty, M; Gibb, I; Goulder, M; Hawkey, C; Hill, N; Reader, S, 2011) |
| "To investigate the effect of 12 weeks of strength training in combination with a nonsteroidal anti-inflammatory drug (NSAID), glucosamine, or placebo on muscle cross-sectional area (CSA), strength (primary outcome parameters), and function, power, pain, and satellite cell number (secondary outcome parameters) in patients with knee osteoarthritis (OA)." | 5.15 | Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. ( Aagaard, P; Beyer, N; Hansen, M; Holm, L; Kjaer, M; Mackey, AL; Petersen, SG, 2011) |
| "One-hundred and seven (107) patients with primary knee osteoarthritis (OA) with pain score of > or =5 were randomized to receive ibuprofen 800 mg per day or C." | 5.14 | Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis. ( Chinswangwatanakul, P; Kuptniratsaikul, V; Thamlikitkul, V; Thanakhumtorn, S; Wattanamongkonsil, L, 2009) |
| "To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare." | 5.12 | A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip. ( De Clerck, L; De Keyser, F; Geusens, P; Hauzeur, JP; Luyten, FP; Malaise, M; Mathy, L; Raeman, F; Van den Bosch, F; Vander Mijnsbrugge, D; Westhovens, R, 2007) |
| "For investigator and patient assessment of knee joint pain, naproxen sodium (440/660 mg) and ibuprofen were clinically effective at relieving pain compared with placebo (n = 444); both treatments reduced the mean symptom score by 30-45%, compared with a 20-25% reduction with placebo." | 5.11 | Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and Ibuprofen in the treatment of osteoarthritis of the knee. ( Minic, M; Schiff, M, 2004) |
| " Patients with flare-up of their osteoarthritis disease process exhibit enhanced levels of markers of joint inflammation and cartilage collagen breakdown, which were markedly decreased by nimesulide but not by ibuprofen." | 5.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "Our data suggest that acetaminophen and ibuprofen are comparably effective in treating knee OA pain, even when the pain is severe." | 5.09 | Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis. ( Bradley, JD; Brandt, KD; Katz, BP, 2001) |
| " All treatments except acetaminophen showed clinically significant improvement from baseline pain." | 4.91 | Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. ( Bannuru, RR; Kent, DM; McAlindon, TE; Schmid, CH; Vaysbrot, EE; Wong, JB, 2015) |
| " In patients with neuropathic pain, topical forms of both capsaicin and lidocaine have been shown to be useful in the treatment of postherpetic neuralgia and diabetic peripheral neuropathic pain." | 4.89 | Topical therapies in the management of chronic pain. ( Galluzzi, KE; Stanos, SP, 2013) |
| "In patients with multiple comorbidities, naproxen- and ibuprofen-containing regimens are more effective and cost-effective in managing OA pain than opioids, celecoxib or SOC." | 3.83 | Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities. ( Collins, JE; Hunter, DJ; Jordan, JM; Katz, JN; Losina, E; Paltiel, AD; Smith, SR; Solomon, DH; Suter, LG; Yelin, E, 2016) |
| " No difference in adverse events was observed between the two groups." | 2.87 | Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial. ( Wang, J, 2018) |
| " angustifolia alone and in combination with B." | 2.84 | Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial. ( Hajhashemi, V; Karimifar, M; Sarrafchi, S; Soltani, R, 2017) |
| " The side effect profile was similar but with fewer gastrointestinal AE reports in the C." | 2.79 | Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. ( Buntragulpoontawee, M; Chootip, C; Dajpratham, P; Kuptniratsaikul, V; Laongpech, S; Lukkanapichonchut, P; Saengsuwan, J; Taechaarpornkul, W; Tantayakom, K, 2014) |
| "Only patients who had everyday joint pain for the past 3 months and "moderate" to "severe" global pain intensity in the involved hip/knee of within the last 48 h were enrolled." | 2.79 | Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee. ( Böttcher, E; Eller, N; Hawel, R; Mitterhuber, J; Rieger, JD; Stallinger, S; Zamani, O, 2014) |
| "Ibuprofen PH was not superior to conventional ultrasound in patients with knee osteoarthritis." | 2.71 | Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis. ( Basaran, S; Guler-Uysal, F; Guzel, R; Kozanoglu, E, 2003) |
| " No adverse event was recorded." | 2.71 | Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. ( Fischer, M; Schreyger, F; Trnavský, K; Vögtle-Junkert, U, 2004) |
| "We analysed 130 persons with osteoarthritis of knee and compared efficiency Deep Relief gel with sonophoresis and ultrasound with standard gel." | 2.71 | [Deep Relief sonophoresis in degenerative changes of the knee joint]. ( Avdić, D; Halilbegović, E; Hotić, A; Kapidzić, N; Lukać, T; Muftić, M; Stefanovski, G; Stefanovski, M; Zjuzin, N; Zubcević, H, 2004) |
| " No drug-related adverse events were recorded." | 2.70 | Treatment of knee osteoarthritis with a topical non-steroidal antiinflammatory drug. Results of a randomized, double-blind, placebo-controlled study on the efficacy and safety of a 5% ibuprofen cream. ( Fimmers, R; Gubzová, Z; Lenhard, G; Miceková, D; Rovenský, J; Schreyger, F; Vögtle-Junkert, U, 2001) |
| "Ibuprofen has been found to result in approximately 50-60% improvement over placebo in WOMAC scores, including those reflecting inflammatory joint pain in knee and hip OA or other indices of pain, disability and impaired function." | 2.48 | Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials. ( Adatia, A; Kean, WF; Rainsford, KD, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.13) | 18.2507 |
| 2000's | 13 (27.66) | 29.6817 |
| 2010's | 30 (63.83) | 24.3611 |
| 2020's | 3 (6.38) | 2.80 |
| Authors | Studies |
|---|---|
| Skou, ST | 2 |
| Roos, EM | 2 |
| Laursen, M | 1 |
| Arendt-Nielsen, L | 3 |
| Rasmussen, S | 2 |
| Simonsen, O | 3 |
| Ibsen, R | 1 |
| Larsen, AT | 1 |
| Kjellberg, J | 1 |
| Persson, MSM | 1 |
| Stocks, J | 1 |
| Sarmanova, A | 1 |
| Fernandes, G | 1 |
| Walsh, DA | 1 |
| Doherty, M | 3 |
| Zhang, W | 2 |
| Gomes, TPO | 1 |
| Souza, JIN | 1 |
| Somerlate, LC | 1 |
| Mendonça, VA | 1 |
| Lima, NM | 1 |
| Carli, GP | 1 |
| Castro, SBR | 1 |
| de Jesus A S Andrade, T | 1 |
| Dias, JVL | 1 |
| Oliveira, MAL | 1 |
| Alves, CCS | 1 |
| Carli, AP | 1 |
| Karimifar, M | 1 |
| Soltani, R | 1 |
| Hajhashemi, V | 1 |
| Sarrafchi, S | 1 |
| Wang, J | 1 |
| Coskun Benlidayi, I | 1 |
| Gokcen, N | 1 |
| Basaran, S | 2 |
| Çepni Kütahya, E | 1 |
| Oc, B | 1 |
| Ugurluoglu, C | 1 |
| Duman, I | 1 |
| Arun, O | 1 |
| Liu, SC | 1 |
| Qiao, XF | 1 |
| Tang, QX | 1 |
| Li, XG | 1 |
| Yang, JH | 1 |
| Wang, TQ | 1 |
| Xiao, YJ | 1 |
| Qiao, JM | 1 |
| Petersen, KK | 1 |
| Olesen, AE | 1 |
| Mørch, CD | 1 |
| Gallelli, L | 2 |
| Galasso, O | 2 |
| Falcone, D | 2 |
| Southworth, S | 1 |
| Greco, M | 1 |
| Ventura, V | 1 |
| Romualdi, P | 1 |
| Corigliano, A | 2 |
| Terracciano, R | 2 |
| Savino, R | 2 |
| Gulletta, E | 1 |
| Gasparini, G | 2 |
| De Sarro, G | 2 |
| Stanos, SP | 1 |
| Galluzzi, KE | 1 |
| Kuptniratsaikul, V | 3 |
| Dajpratham, P | 1 |
| Taechaarpornkul, W | 1 |
| Buntragulpoontawee, M | 1 |
| Lukkanapichonchut, P | 1 |
| Chootip, C | 1 |
| Saengsuwan, J | 1 |
| Tantayakom, K | 1 |
| Laongpech, S | 1 |
| Zamani, O | 1 |
| Böttcher, E | 1 |
| Rieger, JD | 1 |
| Mitterhuber, J | 1 |
| Hawel, R | 1 |
| Stallinger, S | 1 |
| Eller, N | 1 |
| Tufan, F | 1 |
| Chiranthanut, N | 1 |
| Hanprasertpong, N | 1 |
| Teekachunhatean, S | 1 |
| Bannuru, RR | 1 |
| Schmid, CH | 1 |
| Kent, DM | 1 |
| Vaysbrot, EE | 1 |
| Wong, JB | 1 |
| McAlindon, TE | 1 |
| Laursen, MB | 1 |
| Rathleff, MS | 1 |
| Katz, JN | 1 |
| Smith, SR | 1 |
| Collins, JE | 1 |
| Solomon, DH | 1 |
| Jordan, JM | 1 |
| Hunter, DJ | 1 |
| Suter, LG | 1 |
| Yelin, E | 1 |
| Paltiel, AD | 1 |
| Losina, E | 1 |
| Lee, T | 1 |
| Lu, N | 1 |
| Felson, DT | 1 |
| Choi, HK | 1 |
| Dalal, DS | 1 |
| Zhang, Y | 1 |
| Dubreuil, M | 1 |
| Elsaman, AM | 1 |
| Radwan, AR | 1 |
| Mohammed, WI | 1 |
| Ohrndorf, S | 1 |
| Papou, A | 1 |
| Hussain, S | 1 |
| McWilliams, D | 1 |
| Gordo, AC | 1 |
| Walker, C | 1 |
| Armada, B | 1 |
| Zhou, D | 1 |
| Castelnuovo, E | 1 |
| Cross, P | 1 |
| Mt-Isa, S | 1 |
| Spencer, A | 1 |
| Underwood, M | 1 |
| Thanakhumtorn, S | 1 |
| Chinswangwatanakul, P | 1 |
| Wattanamongkonsil, L | 1 |
| Thamlikitkul, V | 1 |
| Petersen, SG | 2 |
| Saxne, T | 1 |
| Heinegard, D | 1 |
| Hansen, M | 2 |
| Holm, L | 2 |
| Koskinen, S | 1 |
| Stordal, C | 1 |
| Christensen, H | 1 |
| Aagaard, P | 2 |
| Kjaer, M | 2 |
| Kellner, H | 1 |
| Kessenich, CR | 1 |
| Hawkey, C | 1 |
| Goulder, M | 1 |
| Gibb, I | 1 |
| Hill, N | 1 |
| Aspley, S | 1 |
| Reader, S | 1 |
| Beyer, N | 1 |
| Mackey, AL | 1 |
| Woitzek, K | 1 |
| Bond, M | 1 |
| Davis, A | 1 |
| Lohmander, S | 1 |
| Hawker, G | 1 |
| Adatia, A | 1 |
| Rainsford, KD | 1 |
| Kean, WF | 1 |
| Woodhouse, LJ | 1 |
| Urzino, A | 1 |
| Saccà, S | 1 |
| Palleria, C | 1 |
| Longo, P | 1 |
| Southworth, SR | 1 |
| Kozanoglu, E | 1 |
| Guzel, R | 1 |
| Guler-Uysal, F | 1 |
| Trnavský, K | 1 |
| Fischer, M | 1 |
| Vögtle-Junkert, U | 2 |
| Schreyger, F | 2 |
| Gineyts, E | 1 |
| Mo, JA | 1 |
| Ko, A | 1 |
| Henriksen, DB | 1 |
| Curtis, SP | 1 |
| Gertz, BJ | 1 |
| Garnero, P | 1 |
| Delmas, PD | 1 |
| Schiff, M | 1 |
| Minic, M | 1 |
| Boureau, F | 1 |
| Schneid, H | 1 |
| Zeghari, N | 1 |
| Wall, R | 1 |
| Bourgeois, P | 1 |
| Zjuzin, N | 1 |
| Muftić, M | 1 |
| Avdić, D | 1 |
| Zubcević, H | 1 |
| Stefanovski, M | 1 |
| Stefanovski, G | 1 |
| Lukać, T | 1 |
| Hotić, A | 1 |
| Halilbegović, E | 1 |
| Kapidzić, N | 1 |
| Manicourt, DH | 1 |
| Bevilacqua, M | 1 |
| Righini, V | 1 |
| Famaey, JP | 1 |
| Devogelaer, JP | 1 |
| Reijman, M | 1 |
| Bierma-Zeinstra, SM | 1 |
| Pols, HA | 1 |
| Koes, BW | 1 |
| Stricker, BH | 1 |
| Hazes, JM | 1 |
| Luyten, FP | 1 |
| Geusens, P | 1 |
| Malaise, M | 1 |
| De Clerck, L | 1 |
| Westhovens, R | 1 |
| Raeman, F | 1 |
| Vander Mijnsbrugge, D | 1 |
| Mathy, L | 1 |
| Hauzeur, JP | 1 |
| De Keyser, F | 1 |
| Van den Bosch, F | 1 |
| Bradley, JD | 1 |
| Katz, BP | 1 |
| Brandt, KD | 1 |
| Müller-Fassbender, H | 1 |
| Bach, GL | 1 |
| Haase, W | 1 |
| Rovati, LC | 1 |
| Setnikar, I | 1 |
| Rovenský, J | 1 |
| Miceková, D | 1 |
| Gubzová, Z | 1 |
| Fimmers, R | 1 |
| Lenhard, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Structured Non-operative Treatment of Knee Osteoarthritis - a Randomized Controlled Trial of Pain, Physical Function and Quality of Life With 12months Follow-up[NCT01535001] | 100 participants (Actual) | Interventional | 2012-02-29 | Completed | |||
| Identifying Treatment Responders to a Topical Non-steroidal Anti-inflammatory Drug (NSAID) or Topical Capsaicin in Painful Knee Osteoarthritis: A Pilot Series of N-of-1 Trials[NCT03146689] | 22 participants (Actual) | Interventional | 2017-08-04 | Completed | |||
| Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu[NCT06105840] | Phase 1/Phase 2 | 70 participants (Anticipated) | Interventional | 2023-08-27 | Enrolling by invitation | ||
| Reduce Pain and Improve Quality of Life in Patient With Knee Osteoarthritis by Light, Sound and Brain Stimulation[NCT04321655] | 160 participants (Anticipated) | Interventional | 2022-04-01 | Not yet recruiting | |||
| EFFECTS OF NSAIDs ON CLINICAL OUTCOMES, SYNOVIAL FLUID CYTOKINE CONCENTRATION AND SIGNAL TRANSDUCTION PATHWAYS IN KNEE OSTEOARTHRITIS[NCT01860833] | Phase 4 | 90 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| Trial Evaluating multimOdal toPical Cream In CompArison to pLacebo (TOPICAL)[NCT03199417] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2017-05-01 | Terminated (stopped due to Terminated prematurely due to feasibility issues with rate of recruitment) | ||
| The Efficacy and Safety of Curcuma Domestica Extracts and Ibuprofen for Therapy of Patients With Knee Osteoarthritis, the Randomized Double-blinded Controlled Trial, Multicenter Study[NCT00792818] | Phase 3 | 367 participants (Actual) | Interventional | 2008-12-31 | Completed | ||
| A Randomized, Single-blind, Placebo-controlled Study to Evaluate the Effects of a Turmeric and Black Cumin Seed Formulation on Cholesterol Levels Among Generally Healthy Participants[NCT03175757] | 33 participants (Actual) | Interventional | 2017-05-12 | Completed | |||
| Pilot, Open Non-controled Trial to Assess the Feasibility of Implementing Objective Parameters as Primary Endpoints in a Clinical Trial With Patients Affected by Knee Osteoarthritis[NCT03421054] | 8 participants (Actual) | Interventional | 2018-03-19 | Completed | |||
| Double Blind, Placebo Controlled Trial to Evaluate the Effects of a Nutraceutical Containing High-Molecular-Weight Hyaluronic Acid (HA) and Acetyl-11-Keto-Beta-Boswellic Acid (AKBA) in Patients Affected by Knee Osteoarthritis[NCT03612986] | 72 participants (Actual) | Interventional | 2018-08-22 | Completed | |||
| Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment[NCT05986513] | 66 participants (Anticipated) | Interventional | 2023-09-01 | Not yet recruiting | |||
| A Study of the Efficacy and Tolerability of Once Daily Celebrex (Celecoxib) and Three Times Daily Ibuprofen vs. Placebo in the Treatment of Subjects With Osteoarthritis of the Knee[NCT00630929] | Phase 4 | 388 participants (Actual) | Interventional | 2003-01-31 | Completed | ||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients[NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| Effect of Glucosamine or Ibuprofen Combined With Physical Training in Patients With Knee-Osteoarthritis[NCT00833157] | Phase 1 | 36 participants (Actual) | Interventional | 2005-02-28 | Active, not recruiting | ||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01535001)
Timeframe: Primary: 12months.
| Intervention | sec (Mean) |
|---|---|
| MEDIC | -1.2 |
| Standard Treatment | -0.6 |
"The average score for four of the five KOOS subscales, covering pain, symptoms, difficulties in functions of daily living, and quality of life (KOOS4), with scores ranging from 0 (worst) to 100 (best).~Between group comparisons of treatment effect (change in KOOS4 from baseline to 1 year follow-up) will be dependent on data distribution. We expect the change to be normally distributed and analysis will be made using a mixed model ANOVA with subject being a random factor and visit (baseline, 3, 6 and 12 months), treatment arm (TKA + MEDIC, MEDIC) and site (Frederikshavn, Farsoe) being fixed factors. Baseline KOOS4 will be a covariate. Furthermore interactions between the fixed factors will be included in the model. P-values and 95% CI will be presented to assess superiority." (NCT01535001)
Timeframe: Primary: 12months.
| Intervention | units on a scale (Mean) |
|---|---|
| MEDIC | 18.2 |
| Standard Treatment | 7.1 |
(NCT01535001)
Timeframe: Primary: 12 months.
| Intervention | sec (Mean) |
|---|---|
| MEDIC | -1.4 |
| Standard Treatment | -1.1 |
Adverse events (AE) and seriously adverse events (SAE) will be registered in three ways and divided into index knee or sites other than index knee. The project physiotherapist will record any adverse events that the participant experiences or tells them about. For the participants allocated to, or crossing over to, TKA, a project worker will look through hospital records to register if any pre-defined perioperative and postoperative adverse events occurred. At all follow-ups, the assessor will use open-probe questioning to assess adverse events in all participants. (NCT01535001)
Timeframe: Primary: 12months.
| Intervention | Serious adverse events related to knee (Number) |
|---|---|
| MEDIC | 13 |
| Standard Treatment | 24 |
Weight change in kg measured without shoes at the same time of day and on the same scale (NCT01535001)
Timeframe: Primary: 12months.
| Intervention | kg (Mean) |
|---|---|
| MEDIC | -2.4 |
| Standard Treatment | -2.4 |
"Between groups comparisons of the change from baseline to the 1 year follow-up in all secondary endpoint will be handled similar to the primary endpoint. See statistical analysis plan for further description (available under Links).~Range of EQ-5D Descriptive Index is -0.59 to 1.00 (worst to best), while the EQ VAS goes from 0 to 100 (worst to best)." (NCT01535001)
Timeframe: Primary: 12months.
| Intervention | units on a scale (Mean) | |
|---|---|---|
| Descriptive index | EQ VAS | |
| MEDIC | 0.140 | 5.3 |
| Standard Treatment | 0.075 | 7.2 |
Range of all subscales are 0 to 100 (worst to best). (NCT01535001)
Timeframe: Primary: 12 months.
| Intervention | units on a scale (Number) | ||||
|---|---|---|---|---|---|
| Pain | Symptoms | Activities of Daily Living | Sports and recreation | Quality of Life | |
| MEDIC | 18.7 | 16.3 | 18.7 | 16.0 | 19.0 |
| Standard Treatment | 9.3 | 7.7 | 5.9 | 12.0 | 5.5 |
With possible answers being yes and no (NCT01535001)
Timeframe: Baseline and 12months.
| Intervention | proportion of participants (Number) | |
|---|---|---|
| Baseline | 12months | |
| MEDIC | 0.64 | 0.39 |
| Standard Treatment | 0.56 | 0.57 |
3 reviews available for ibuprofen and Osteoarthritis, Knee
| Article | Year |
|---|---|
Topical therapies in the management of chronic pain.
Topics: Administration, Cutaneous; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2013 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.
Topics: Acetaminophen; Adrenal Cortex Hormones; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2015 |
Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Hip; Hip Joint; Humans; Ibuprofen; Knee; Knee J | 2012 |
32 trials available for ibuprofen and Osteoarthritis, Knee
| Article | Year |
|---|---|
Cost-effectiveness of 12 weeks of supervised treatment compared to written advice in patients with knee osteoarthritis: a secondary analysis of the 2-year outcome from a randomized trial.
Topics: Aged; Analgesics, Non-Narcotic; Cost-Benefit Analysis; Denmark; Diet Therapy; Exercise Therapy; Fema | 2020 |
Individual responses to topical ibuprofen gel or capsaicin cream for painful knee osteoarthritis: a series of n-of-1 trials.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Female; Hu | 2021 |
Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Curcuma; Female | 2021 |
Evaluation of the effect of Elaeagnus angustifolia alone and combined with Boswellia thurifera compared with ibuprofen in patients with knee osteoarthritis: a randomized double-blind controlled clinical trial.
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Boswellia; Double-Blind Method; Elaeagna | 2017 |
Efficacy and safety of adalimumab by intra-articular injection for moderate to severe knee osteoarthritis: An open-label randomized controlled trial.
Topics: Adalimumab; Aged; Antirheumatic Agents; Celecoxib; Diclofenac; Female; Humans; Hyaluronic Acid; Ibup | 2018 |
Comparative short-term effectiveness of ibuprofen gel and cream phonophoresis in patients with knee osteoarthritis.
Topics: Administration, Cutaneous; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2018 |
The effects of nonsteroidal anti-inflammatory drugs on clinical outcomes, synovial fluid cytokine concentration and signal transduction pathways in knee osteoarthritis. A randomized open label trial.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2 Inhibi | 2013 |
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Middle Aged; Oste | 2014 |
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Middle Aged; Oste | 2014 |
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Middle Aged; Oste | 2014 |
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Middle Aged; Oste | 2014 |
Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ster | 2014 |
Thai massage, and Thai herbal compress versus oral ibuprofen in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial.
Topics: Acupressure; Aged; Compression Bandages; Drugs, Chinese Herbal; Female; Humans; Ibuprofen; Knee; Mal | 2014 |
The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diet, Reduci | 2016 |
The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diet, Reduci | 2016 |
The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diet, Reduci | 2016 |
The efficacy of non-surgical treatment on pain and sensitization in patients with knee osteoarthritis: a pre-defined ancillary analysis from a randomized controlled trial.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Diet, Reduci | 2016 |
Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthriti | 2017 |
Efficacy of celecoxib versus ibuprofen for the treatment of patients with osteoarthritis of the knee: A randomized double-blind, non-inferiority trial.
Topics: Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; C | 2017 |
Cost-effectiveness of advising the use of topical or oral ibuprofen for knee pain; the TOIB study [ISRCTN: 79353052].
Topics: Administration, Oral; Administration, Topical; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Age | 2008 |
Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis.
Topics: Aged; Curcuma; Female; Humans; Ibuprofen; Knee Joint; Male; Middle Aged; Osteoarthritis, Knee; Pain; | 2009 |
Glucosamine but not ibuprofen alters cartilage turnover in osteoarthritis patients in response to physical training.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cartilage Oligomeric Matrix Protein; Cart | 2010 |
A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Chronic Disease; Dose-Respo | 2011 |
Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Glucosamine; Humans; Ibu | 2011 |
[Ibuprofen/paracetamol combination therapy is more effective than monotherapy in knee pain, but increases bleeding risk].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pai | 2012 |
Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Disability Evaluation; Doub | 2012 |
Characteristics and clinical implications of the pharmacokinetic profile of ibuprofen in patients with knee osteoarthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Dose-Response R | 2012 |
Short term efficacy of ibuprofen phonophoresis versus continuous ultrasound therapy in knee osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Health Services Res | 2003 |
Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Bl | 2004 |
Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis.
Topics: Acute Disease; Aged; Amino Acids; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Bio | 2004 |
Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and Ibuprofen in the treatment of osteoarthritis of the knee.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Method; Female; Humans; Ibup | 2004 |
The IPSO study: ibuprofen, paracetamol study in osteoarthritis. A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anthropometry; Double-Blind Method | 2004 |
[Deep Relief sonophoresis in degenerative changes of the knee joint].
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Female; Gels; Humans; Ibuprofen; Male; Midd | 2004 |
Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Collagen; Collagen Typ | 2005 |
A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotherapy, Adjuva | 2007 |
Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroid | 2001 |
Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Glucosamine; Hum | 1994 |
Treatment of knee osteoarthritis with a topical non-steroidal antiinflammatory drug. Results of a randomized, double-blind, placebo-controlled study on the efficacy and safety of a 5% ibuprofen cream.
Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; | 2001 |
12 other studies available for ibuprofen and Osteoarthritis, Knee
| Article | Year |
|---|---|
The effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Disease Models, Animal; Ibup | 2019 |
A retrospective study of acupuncture as an adjunctive therapy to topical ibuprofen for chronic knee pain due to osteoarthritis.
Topics: Acupuncture Therapy; Administration, Cutaneous; Aged; Aged, 80 and over; Chronic Disease; Combined M | 2019 |
Pain inhibitory mechanisms and response to weak analgesics in patients with knee osteoarthritis.
Topics: Acetaminophen; Aged; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; A | 2019 |
Importance of acute renal failure with ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Osteoarthritis, K | 2014 |
Author's reply: To PMID 24672232.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Curcuma; Female; Humans; Ibuprofen; Male; Osteoarthritis, K | 2014 |
Cost-effectiveness of nonsteroidal anti-inflammatory drugs and opioids in the treatment of knee osteoarthritis in older patients with multiple comorbidities.
Topics: Aged; Aged, 80 and over; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Com | 2016 |
Use of non-steroidal anti-inflammatory drugs correlates with the risk of venous thromboembolism in knee osteoarthritis patients: a UK population-based case-control study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cyclooxygenase 2 Inhibitors; Di | 2016 |
Low-dose Spironolactone: Treatment for Osteoarthritis-related Knee Effusion. A Prospective Clinical and Sonographic-based Study.
Topics: Adult; Anti-Inflammatory Agents; Cryotherapy; Exudates and Transudates; Female; Humans; Ibuprofen; K | 2016 |
[Aspirin-induced asthma in patients with osteoarthritis].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma, Aspirin-Induced; Female; Humans; Ibuprofen | 2010 |
Understanding idiosyncratic drug-induced neutropenia.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Leukocyte Count; Neutropen | 2010 |
Do Ibuprofen or glucosamine in addition to resistance exercise training improve muscle strength in patients with knee osteoarthritis?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Female; Glucosamine; Humans; Ibuprofen; Male; Muscle Streng | 2012 |
Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Progression; Female; Follow-Up St | 2005 |