ibuprofen has been researched along with Osteoarthritis, Hip in 18 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Osteoarthritis, Hip: Noninflammatory degenerative disease of the hip joint which usually appears in late middle or old age. It is characterized by growth or maturational disturbances in the femoral neck and head, as well as acetabular dysplasia. A dominant symptom is pain on weight-bearing or motion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare." | 9.12 | A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip. ( De Clerck, L; De Keyser, F; Geusens, P; Hauzeur, JP; Luyten, FP; Malaise, M; Mathy, L; Raeman, F; Van den Bosch, F; Vander Mijnsbrugge, D; Westhovens, R, 2007) |
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 9.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The pharmacokinetics of the enantiomers of ibuprofen have been investigated following oral administration of 300 or 600 mg of racemic ibuprofen four times daily to 45 patients with osteoarthritis." | 9.07 | Variability in the disposition of ibuprofen enantiomers in osteoarthritis patients. ( Bradley, JD; Hall, SD; Kalasinski, LA; Rudy, AC; Ryan, SI; Xiaotao, Q, 1992) |
| "To compare the effects of continuous and intermittent celecoxib treatment in patients with knee or hip osteoarthritis in flare." | 5.12 | A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip. ( De Clerck, L; De Keyser, F; Geusens, P; Hauzeur, JP; Luyten, FP; Malaise, M; Mathy, L; Raeman, F; Van den Bosch, F; Vander Mijnsbrugge, D; Westhovens, R, 2007) |
| "Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with flare-up of knee or hip osteoarthritis." | 5.11 | Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis. ( Bevilacqua, M; Devogelaer, JP; Famaey, JP; Manicourt, DH; Righini, V, 2005) |
| "The pharmacokinetics of the enantiomers of ibuprofen have been investigated following oral administration of 300 or 600 mg of racemic ibuprofen four times daily to 45 patients with osteoarthritis." | 5.07 | Variability in the disposition of ibuprofen enantiomers in osteoarthritis patients. ( Bradley, JD; Hall, SD; Kalasinski, LA; Rudy, AC; Ryan, SI; Xiaotao, Q, 1992) |
| " Gastrointestinal adverse drug reactions were reported in 8 patients (3." | 2.79 | Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee. ( Böttcher, E; Eller, N; Hawel, R; Mitterhuber, J; Rieger, JD; Stallinger, S; Zamani, O, 2014) |
| " The main parameter was the incidence of clinical adverse events." | 2.70 | Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders. ( Mayrhofer, F, 2001) |
| "Both ibuprofen-treated groups showed significantly less HO than the placebo-treated group." | 2.69 | Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time. ( Nilsson, OS; Persson, PE; Sodemann, B, 1998) |
| " For the symptomatic treatment of painful disorders a dose-response relationship of the NSAID should be a basic requirement, which is difficult to be proven in studies because rheumatic diseases are heterogenous in terms of clinical involvement." | 2.69 | Evaluation of the efficacy and dose-response relationship of dexibuprofen (S(+)-ibuprofen) in patients with osteoarthritis of the hip and comparison with racemic ibuprofen using the WOMAC osteoarthritis index. ( Hawel, R; Klein, G; Kollenz, CJ; Mayrhofer, F; Singer, F, 2000) |
| "Ibuprofen has been found to result in approximately 50-60% improvement over placebo in WOMAC scores, including those reflecting inflammatory joint pain in knee and hip OA or other indices of pain, disability and impaired function." | 2.48 | Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials. ( Adatia, A; Kean, WF; Rainsford, KD, 2012) |
| "5:1, dexibuprofen was found to be at least as efficacious as racemic ibuprofen; 75% of the maximum daily dose of dexibuprofen was equally efficacious as 100% of MDD of diclofenac; no influence was found of meals on bioavailability and a significant doseresponse relationship; there was clinical efficacy in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis of the hip, osteoarthritis of the knee, lumbar vertebral syndrome, distortion of the ankle joint and dysmenorrhoea; there was good tolerability compared to other NSAIDs: racemic ibuprofen showed a 30% and diclofenac a 90% higher incidence of adverse drug reactions; the long-term study stated a 15." | 2.41 | Overview on clinical data of dexibuprofen. ( Phleps, W, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (38.89) | 18.2507 |
| 2000's | 8 (44.44) | 29.6817 |
| 2010's | 3 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zamani, O | 1 |
| Böttcher, E | 1 |
| Rieger, JD | 1 |
| Mitterhuber, J | 1 |
| Hawel, R | 3 |
| Stallinger, S | 1 |
| Eller, N | 1 |
| Bond, M | 1 |
| Davis, A | 1 |
| Lohmander, S | 1 |
| Hawker, G | 1 |
| Adatia, A | 1 |
| Rainsford, KD | 1 |
| Kean, WF | 1 |
| Klein, G | 2 |
| Singer, F | 2 |
| Mayrhofer, F | 3 |
| Kähler, ST | 1 |
| Boureau, F | 1 |
| Schneid, H | 1 |
| Zeghari, N | 1 |
| Wall, R | 1 |
| Bourgeois, P | 1 |
| Manicourt, DH | 1 |
| Bevilacqua, M | 1 |
| Righini, V | 1 |
| Famaey, JP | 1 |
| Devogelaer, JP | 1 |
| Reijman, M | 1 |
| Bierma-Zeinstra, SM | 1 |
| Pols, HA | 1 |
| Koes, BW | 1 |
| Stricker, BH | 1 |
| Hazes, JM | 1 |
| Luyten, FP | 1 |
| Geusens, P | 1 |
| Malaise, M | 1 |
| De Clerck, L | 1 |
| Westhovens, R | 1 |
| Raeman, F | 1 |
| Vander Mijnsbrugge, D | 1 |
| Mathy, L | 1 |
| Hauzeur, JP | 1 |
| De Keyser, F | 1 |
| Van den Bosch, F | 1 |
| Hamdy, RC | 1 |
| Moore, SW | 1 |
| Micklewright, M | 1 |
| Beecham, VF | 1 |
| Rahlfs, VW | 1 |
| Stat, C | 1 |
| Persson, PE | 1 |
| Sodemann, B | 1 |
| Nilsson, OS | 1 |
| Koorevaar, CT | 1 |
| Hu, HP | 1 |
| Lemmens, A | 1 |
| van Kampen, A | 1 |
| Kollenz, CJ | 1 |
| Phleps, W | 1 |
| Quiding, H | 1 |
| Grimstad, J | 1 |
| Rusten, K | 1 |
| Stubhaug, A | 1 |
| Bremnes, J | 1 |
| Breivik, H | 1 |
| Rudy, AC | 1 |
| Bradley, JD | 1 |
| Ryan, SI | 1 |
| Kalasinski, LA | 1 |
| Xiaotao, Q | 1 |
| Hall, SD | 1 |
| Kaik, B | 1 |
| Bauer, K | 1 |
| Bröll, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for ibuprofen and Osteoarthritis, Hip
| Article | Year |
|---|---|
Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Hip; Hip Joint; Humans; Ibuprofen; Knee; Knee J | 2012 |
Overview on clinical data of dexibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Dysmenorrhea; Female; Humans; Ibuprofen; | 2001 |
13 trials available for ibuprofen and Osteoarthritis, Hip
| Article | Year |
|---|---|
Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ster | 2014 |
Responsiveness of the OARSI-OMERACT osteoarthritis pain and function measures.
Topics: Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Disability Evaluation; Doub | 2012 |
Comparison of the efficacy and tolerability of dexibuprofen and celecoxib in the treatment of osteoarthritis of the hip.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 | 2003 |
The IPSO study: ibuprofen, paracetamol study in osteoarthritis. A randomised comparative clinical study comparing the efficacy and safety of ibuprofen and paracetamol analgesic treatment of osteoarthritis of the knee or hip.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anthropometry; Double-Blind Method | 2004 |
Comparative effect of nimesulide and ibuprofen on the urinary levels of collagen type II C-telopeptide degradation products and on the serum levels of hyaluronan and matrix metalloproteinases-3 and -13 in patients with flare-up of osteoarthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Collagen; Collagen Typ | 2005 |
A prospective randomised multicentre study comparing continuous and intermittent treatment with celecoxib in patients with osteoarthritis of the knee or hip.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Chemotherapy, Adjuva | 2007 |
Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Double-Blind Method; Female | 1998 |
No effective prophylaxis of heterotopic ossification with short-term ibuprofen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, | 1999 |
Evaluation of the efficacy and dose-response relationship of dexibuprofen (S(+)-ibuprofen) in patients with osteoarthritis of the hip and comparison with racemic ibuprofen using the WOMAC osteoarthritis index.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double-Blind Method; Drug | 2000 |
Efficacy and long-term safety of dexibuprofen [S(+)-ibuprofen]: a short-term efficacy study in patients with osteoarthritis of the hip and a 1-year tolerability study in patients with rheumatic disorders.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Humans; Ibuprofen; Isomer | 2001 |
Ibuprofen plus codeine, ibuprofen, and placebo in a single- and multidose cross-over comparison for coxarthrosis pain.
Topics: Adult; Aged; Codeine; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Female; | 1992 |
Variability in the disposition of ibuprofen enantiomers in osteoarthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administ | 1992 |
Double-blind randomized clinical trial on imidazole salicylate vs ibuprofen in osteoarthritis.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Ibuprofen; Imidazoles; Knee Joint; Male; Middle Ag | 1991 |
3 other studies available for ibuprofen and Osteoarthritis, Hip
| Article | Year |
|---|---|
Is there an association between the use of different types of nonsteroidal antiinflammatory drugs and radiologic progression of osteoarthritis? The Rotterdam Study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Progression; Female; Follow-Up St | 2005 |
When Goody's Powder is not so good.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Heart Failure; Humans; Ibuprofen; Knee Joint; Male; N | 1996 |
Reevaluation of some double-blind, randomized studies of dexibuprofen (Seractil): a state-of-the-art overview. Studies in patients with lumbar vertebral column syndrome, rheumatoid arthritis, distortion of the ankle joint, gonarthrosis, ankylosing spondyl
Topics: Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Hu | 1996 |