ibuprofen has been researched along with Nocturia in 2 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Nocturia: Frequent URINATION at night that interrupts sleep. It is often associated with outflow obstruction, DIABETES MELLITUS, or bladder inflammation (CYSTITIS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, KC | 1 |
| Rauscher, F | 1 |
| Kaminesky, J | 1 |
| Ryndin, I | 1 |
| Xie, L | 1 |
| Zhao, Y | 1 |
| Khusid, JA | 1 |
| Weiss, JP | 1 |
| Wein, AJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Paxerol™ (a Novel Formulation of Acetaminophen and Ibuprofen) for Treatment of Nocturia - A Phase II Placebo-Controlled Trial[NCT02646826] | Phase 2 | 86 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in number of nocturia episodes associated with one of three dose levels of Paxerol vs. placebo is assessed during the 2-week treatment period. (NCT02646826)
Timeframe: Up to 2 weeks
| Intervention | average nightly voids (Mean) | ||
|---|---|---|---|
| Baseline | Two Weeks Using Pills | Change of Nocturia Episodes | |
| Paxerol - Dose Level 1 325 mg Acetaminophen 150 mg Ibuprofen | 3.3 | 2.2 | -1.1 |
| Paxerol - Dose Level 2 650 mg Acetaminophen 300 mg Ibuprofen | 3.9 | 2.5 | -1.4 |
| Paxerol - Dose Level 3 975 mg Acetaminophen 450 mg Ibuprofen | 3.6 | 2.4 | -1.3 |
| Placebo | 3.6 | 3.2 | -0.3 |
The degree of clinical benefit, via NQOL, associated with one of three dose levels of Paxerol vs. placebo is assessed after the 2-week treatment period. This is on a scale of 0 to 100, with 0 being the best score. (NCT02646826)
Timeframe: Up to 2 weeks
| Intervention | score on a scale (Mean) | |
|---|---|---|
| Baseline Quality of Life | Two Weeks Using Pills | |
| Paxerol - Dose Level 1 325 mg Acetaminophen 150 mg Ibuprofen | 52.3 | 40.7 |
| Paxerol - Dose Level 2 650 mg Acetaminophen 300 mg Ibuprofen | 63.6 | 40.5 |
| Paxerol - Dose Level 3 975 mg Acetaminophen 450 mg Ibuprofen | 59.7 | 37.4 |
| Placebo | 52.5 | 42.1 |
DFUS will be assessed during the 2-week treatment period with one of three dose levels of Paxerol vs. placebo (NCT02646826)
Timeframe: Up to 2 weeks
| Intervention | Hours (Mean) | |
|---|---|---|
| Baseline DFUS | Two Weeks Using Pills DFUS | |
| Paxerol - Dose Level 1 325 mg Acetaminophen 150 mg Ibuprofen | 2.2 | 2.8 |
| Paxerol - Dose Level 2 650 mg Acetaminophen 300 mg Ibuprofen | 2.0 | 2.7 |
| Paxerol - Dose Level 3 975 mg Acetaminophen 450 mg Ibuprofen | 2.1 | 3.3 |
| Placebo | 1.8 | 2.2 |
The total hours of nightly sleep will be assessed during the 2-week treatment period with one of three dose levels of Paxerol vs. placebo (NCT02646826)
Timeframe: Up to 2 weeks
| Intervention | Hours per night (Mean) | ||
|---|---|---|---|
| Baseline Hours of Sleep | Two Weeks Using Pills Hours of Sleep | Change from Baseline | |
| Paxerol - Dose Level 1 325 mg Acetaminophen 150 mg Ibuprofen | 7.9 | 7.7 | -0.3 |
| Paxerol - Dose Level 2 650 mg Acetaminophen 300 mg Ibuprofen | 8.6 | 8.5 | -0.2 |
| Paxerol - Dose Level 3 975 mg Acetaminophen 450 mg Ibuprofen | 8.6 | 8.4 | -0.2 |
| Placebo | 8.5 | 8.3 | -0.3 |
1 trial available for ibuprofen and Nocturia
| Article | Year |
|---|---|
Novel immediate/sustained-release formulation of acetaminophen-ibuprofen combination (Paxerol®) for severe nocturia associated with overactive bladder: A multi-center, randomized, double blinded, placebo-controlled, 4-arm trial.
Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Double-Blind Method; Dru | 2019 |
1 other study available for ibuprofen and Nocturia
| Article | Year |
|---|---|
Re: Novel Immediate/Sustained-Release Formulation of Acetaminophen-Ibuprofen Combination (Paxerol®) for Severe Nocturia Associated with Overactive Bladder: A Multi-Center, Randomized, Double Blinded, Placebo-Controlled, 4-Arm Trial.
Topics: Acetaminophen; Delayed-Action Preparations; Double-Blind Method; Humans; Ibuprofen; Nocturia; Urinar | 2019 |