ibuprofen has been researched along with Neuroblastoma in 9 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroblastoma is a common pediatric solid tumor that exhibits a striking clinical bipolarity: favorable and unfavorable." | 5.40 | S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines. ( Hicks, SL; Ikegaki, N; Jacobs, J; Jumbo, AS; Leonhardt, P; Rappaport, EF; Regan, PL; Tang, XX, 2014) |
| "Ibuprofen is a member of the proprionic acid group of nonsteroidal anti-inflammatory drugs (NSAID), with the S-enantiomer being more active than the R-enantiomer." | 5.35 | Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. ( Chen, WN; Ching, CB; Sui, J; Zhang, J, 2008) |
| "Neuroblastoma is the most common extracranial solid tumor in children." | 5.33 | The secretion of ibuprofen metabolites interferes with the capillary chromatography of urinary homovanillic acid and 4-hydroxy-3-methoxymandelic acid in neuroblastoma diagnosis. ( Buoncompagni, A; Caruso, U; De Bernardi, B; Deiana, F; Levreri, I; Marchese, N; Melioli, G, 2005) |
| " We compared the neuroprotective activity of S- and R-enantiomers of flurbiprofen and ibuprofen in a standard assay where secretions from activated human THP-1 or microglial cells are toxic to neuroblastoma SH-SY5Y cells." | 3.72 | S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity. ( Klegeris, A; Maguire, J; McGeer, PL, 2004) |
| " Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, supidimide, significantly stimulated the secretion of the non-amyloidogenic alpha-secretase form of the soluble amyloid precursor protein (sAPP alpha) into the conditioned media of SH-SY5Y neuroblastoma and PC12 cells." | 3.71 | Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. ( Amit, T; Avramovich, Y; Youdim, MB, 2002) |
| "Epidemiological studies have suggested that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced incidence of Alzheimer's disease (AD)." | 1.35 | Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein. ( Czirr, E; Esselmann, H; Leuchtenberger, S; Lichtenthaler, SF; Maler, J; Ness, J; Pietrzik, CU; Weggen, S; Wiltfang, J, 2009) |
| "Ibuprofen is a member of the proprionic acid group of nonsteroidal anti-inflammatory drugs (NSAID), with the S-enantiomer being more active than the R-enantiomer." | 1.35 | Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. ( Chen, WN; Ching, CB; Sui, J; Zhang, J, 2008) |
| "Neuroblastoma is the most common extracranial solid tumor in children." | 1.33 | The secretion of ibuprofen metabolites interferes with the capillary chromatography of urinary homovanillic acid and 4-hydroxy-3-methoxymandelic acid in neuroblastoma diagnosis. ( Buoncompagni, A; Caruso, U; De Bernardi, B; Deiana, F; Levreri, I; Marchese, N; Melioli, G, 2005) |
| "Ibuprofen treatment decreased the secretion of total Abeta in the conditioned media of cytokine stimulated cells by 50% and prevented the accumulation of Abeta-42 and Abeta-40 in detergent soluble cell extracts." | 1.31 | Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells. ( Apochal, A; Blasko, I; Boeck, G; Grubeck-Loebenstein, B; Hartmann, T; Ransmayr, G, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ikegaki, N | 1 |
| Hicks, SL | 1 |
| Regan, PL | 1 |
| Jacobs, J | 1 |
| Jumbo, AS | 1 |
| Leonhardt, P | 1 |
| Rappaport, EF | 1 |
| Tang, XX | 1 |
| Arima, Y | 1 |
| Yoshimoto, K | 1 |
| Namera, A | 1 |
| Makita, R | 1 |
| Murata, K | 1 |
| Nagao, M | 1 |
| Sastre, M | 1 |
| Dewachter, I | 1 |
| Landreth, GE | 1 |
| Willson, TM | 1 |
| Klockgether, T | 1 |
| van Leuven, F | 1 |
| Heneka, MT | 1 |
| Klegeris, A | 1 |
| Maguire, J | 1 |
| McGeer, PL | 1 |
| Levreri, I | 1 |
| Caruso, U | 1 |
| Deiana, F | 1 |
| Buoncompagni, A | 1 |
| De Bernardi, B | 1 |
| Marchese, N | 1 |
| Melioli, G | 1 |
| Leuchtenberger, S | 1 |
| Maler, J | 1 |
| Czirr, E | 1 |
| Ness, J | 1 |
| Lichtenthaler, SF | 1 |
| Esselmann, H | 1 |
| Pietrzik, CU | 1 |
| Wiltfang, J | 1 |
| Weggen, S | 1 |
| Zhang, J | 1 |
| Sui, J | 1 |
| Ching, CB | 1 |
| Chen, WN | 1 |
| Blasko, I | 1 |
| Apochal, A | 1 |
| Boeck, G | 1 |
| Hartmann, T | 1 |
| Grubeck-Loebenstein, B | 1 |
| Ransmayr, G | 1 |
| Avramovich, Y | 1 |
| Amit, T | 1 |
| Youdim, MB | 1 |
9 other studies available for ibuprofen and Neuroblastoma
| Article | Year |
|---|---|
S(+)-ibuprofen destabilizes MYC/MYCN and AKT, increases p53 expression, and induces unfolded protein response and favorable phenotype in neuroblastoma cell lines.
Topics: Apoptosis; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Child; Gene Expression Regulatio | 2014 |
The Sarin-like Organophosphorus Agent bis (isopropyl methyl)phosphonate Induces Apoptotic Cell Death and COX-2 Expression in SK-N-SH Cells.
Topics: Apoptosis; Cell Line, Tumor; Cyclooxygenase 2; Diphosphonates; Humans; Ibuprofen; Neuroblastoma | 2016 |
Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Age | 2003 |
S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Culture Media, Conditioned; Dose- | 2004 |
The secretion of ibuprofen metabolites interferes with the capillary chromatography of urinary homovanillic acid and 4-hydroxy-3-methoxymandelic acid in neuroblastoma diagnosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Catecholamines; Child; Child, Preschool; Chromatography, Ga | 2005 |
Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.
Topics: Alkaline Phosphatase; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroid | 2009 |
Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cell Survival; Cells, Cultur | 2008 |
Ibuprofen decreases cytokine-induced amyloid beta production in neuronal cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2001 |
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein.
Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inh | 2002 |