ibuprofen has been researched along with Migraine Disorders in 71 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine." | 6.55 | Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017) |
| "Sodium valproate and ibuprofen are drugs with known efficacy in the treatment of headache associated with acute migraine attacks." | 5.51 | Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department: A randomized clinical trial. ( Akbas, I; Ceylan, M; Dogruyol, S; Gur, STA; Kocak, AO; Kocak, MB; Tekyol, D, 2022) |
| " In allodynic patients with moderate-to-severe headache, rizatriptan resulted in greater pain relief compared with ibuprofen." | 5.14 | A comparison of migraine patients with and without allodynic symptoms. ( Kalita, J; Misra, UK; Yadav, RK, 2009) |
| " For the acute treatment of migraine attacks or tension-type headache, ibuprofen (10 mg per kg body weight) or acetaminophen (15 mg per kg body weight) are recommended with highest evidence, intranasal sumatriptan (10 to 20 mg) can be given as second choice." | 4.81 | [Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. ( Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M, 2002) |
| "In the present population recruited at specialized headache centers, patients rated triptans as more effective than non-opioid analgesics, naproxen as more effective than ibuprofen, and acute medication efficacy decreased with increasing headache frequency." | 4.31 | What do patients' efficacy and tolerability ratings of acute migraine medication tell us? Cross-sectional data from the DMKG Headache Registry. ( Dresler, T; Förderreuther, S; Gaul, C; Gossrau, G; Jürgens, TP; Ruscheweyh, R; Ruschil, V; Scheidt, J; Straube, A, 2023) |
| "Individuals with episodic migraine were screened at the Jefferson Headache Center." | 3.01 | Intravenous ibuprofen for acute treatment of migraine: A double-blind, randomized, placebo-controlled pilot study. ( Curran, JG; Hopkins, MM; Keith, SW; Silberstein, SD; Yuan, H, 2021) |
| "In patients with severe baseline migraine pain, AAC and IB are significantly more effective than PLA, and AAC provides significantly faster and more effective pain relief than IB." | 2.79 | Results of a multicenter, double-blind, randomized, parallel-group, placebo-controlled, single-dose study comparing the fixed combination of acetaminophen, acetylsalicylic acid, and caffeine with ibuprofen for acute treatment of patients with severe migra ( Gold, M; Goldstein, J; Hagen, M, 2014) |
| "Telcagepant is an oral calcitonin gene-related peptide receptor antagonist which is being evaluated for the acute treatment of migraine." | 2.76 | Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine. ( Brandes, J; Ceesay, P; Gottwald, R; Hewitt, DJ; Ho, TW; Lines, C; Lipton, RB; Martin, V; Schaefer, E, 2011) |
| "Rizatriptan was superior to ibuprofen and placebo in relieving headache at 2 h but not at 24 h." | 2.73 | Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial. ( Kalita, J; Misra, UK; Yadav, RK, 2007) |
| "A total of 1555 migraineurs were included in the analysis." | 2.72 | Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. ( Goldstein, J; Lipton, RB; Ryan, RE; Saper, JR; Silberstein, SD, 2006) |
| "Adult migraineurs (n = 783) treated one migraine attack with either rofecoxib (25 or 50 mg), ibuprofen 400 mg, or placebo in a randomized, double-blind study." | 2.72 | Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial. ( Barraclough, E; Dahlof, C; Klipfel, M; Lines, C; Loeys, T; Malbecq, W; Reines, S; Saper, J; So, Y; Tfelt-Hansen, P; Visser, H; Yuen, E, 2006) |
| "Both ibuprofen and rofecoxib were superior to placebo in aborting an acute migraine attack, and there was no significant difference in their efficacy in an acute migraine attack." | 2.71 | Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial. ( Jose, M; Kalita, J; Misra, UK, 2004) |
| "A total of 729 migraine sufferers with moderate to severe baseline pain evaluated a single 200, 400 or 600 mg dose of a new liquigel formulation of ibuprofen over 8 h." | 2.69 | Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study. ( Cooper, SA; Evans, FT; Furey, SA; Geetha, R; Kellstein, DE; Koronkiewicz, K; Lipton, RB; Stewart, WF; Subramanian, T; Wilkes, K, 2000) |
| "Forty migraine patients participated in this multicenter, double-blind, crossover, randomized, placebo-controlled trial." | 2.69 | Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks. ( Franchini, S; Granella, F; Lanfranchi, S; Manzoni, GC; Nappi, G; Sandrini, G, 1998) |
| "Ibuprofen was twice as likely as acetaminophen to abort migraine within 2 hours." | 2.68 | Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study. ( Hämäläinen, ML; Hoppu, K; Santavuori, P; Valkeila, E, 1997) |
| "Ibuprofen was well tolerated and no marked side effects were reported during the trial." | 2.66 | Treatment of acute migraine attack: ibuprofen and placebo compared. ( Havanka-Kanniainen, H, 1989) |
| " Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine." | 2.55 | Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017) |
| "Migraine is a neurological disorder resulting in large socioeconomic burden." | 2.53 | Network meta-analysis of migraine disorder treatment by NSAIDs and triptans. ( Han, W; Li, M; Wang, J; Xu, H, 2016) |
| "Oral dihydroergotamine was not superior to placebo in one small study involving 13 children." | 2.53 | Drugs for the acute treatment of migraine in children and adolescents. ( Billinghurst, L; Crumley, ET; Durec, T; Hartling, L; Klassen, TP; Linsdell, MA; Richer, L; Russell, K; Vandermeer, B, 2016) |
| "Ibuprofen is an effective treatment for acute migraine headaches, providing pain relief in about half of sufferers, but complete relief from pain and associated symptoms for only a minority." | 2.49 | Ibuprofen with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; Moore, RA; Rabbie, R, 2013) |
| "For the acute treatment of migraine, we recommend the use of ibuprofen or acetaminophen for mild, moderate or severe headache." | 2.48 | Treating pediatric migraine: an expert opinion. ( Hershey, AD; Kabbouche, MA; O'Brien, HL, 2012) |
| "Ibuprofen is an effective treatment for acute migraine headaches, providing pain relief in about half of sufferers, but complete relief from pain and associated symptoms for only a minority." | 2.46 | Ibuprofen with or without an antiemetic for acute migraine headaches in adults. ( Derry, S; McQuay, HJ; Moore, RA; Rabbie, R, 2010) |
| "The MeSH search terms used were migraine disorders, headache, vascular headache, ibuprofen, adult, and clinical trial." | 2.44 | Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis. ( Kittikulsuth, W; Poolsup, N; Pudchakan, P; Suthisisang, C; Wiwatpanich, P, 2007) |
| "In the acute migraine attack, a single dose of either ibuprofen 10 mg/kg or paracetamol 15 mg/kg has been shown to be effective, with only a few adverse effects." | 2.43 | [Pharmacologic treatment of acute migraine attack in children]. ( Auvin, S; Cuvellier, JC; Joriot, S; Vallée, L, 2005) |
| "Treatment of pediatric migraine includes an individually tailored regimen of both nonpharmacologic and pharmacologic measures." | 2.43 | Symptomatic treatment of migraine in children: a systematic review of medication trials. ( Berger, MY; Bruijn, JK; Damen, L; Koes, BW; Passchier, J; Verhagen, AP, 2005) |
| "Most headaches are benign, but all require appropriate assessment." | 2.41 | "Nurse, my head hurts": a review of childhood headaches. ( Fisher, W; Gordon, V; Kolar, KR, 2001) |
| "The most detailed posts on headache or migraine were from Germany." | 1.91 | Social Media Listening and Digital Profiling Study of People With Headache and Migraine: Retrospective Infodemiology Study. ( Amand, C; Constantin, L; Goadsby, P; Ruiz de la Torre, E, 2023) |
| "Fifty children, with 116 migraine attacks, were included in the study (30 females; mean age 12; range 6-18)." | 1.72 | Migraine abortive treatment in children and adolescents in Israel. ( Cohen, R; Genizi, J; Lahoud, D, 2022) |
| "There were 207 children with migraine over a 1 year period." | 1.72 | Intravenous chlorpromazine for acute paediatric migraine. ( Babl, FE; Hill, A; Löllgen, RM; Mackay, MT; Palmer, GM, 2022) |
| "These drugs can be categorized into migraine-specific and migraine-non-specific." | 1.72 | 2022 Taiwan Guidelines for Acute Treatment of Migraine. ( Lau, CI; Wang, YF, 2022) |
| "Migraines are a broad spectrum of disorders classified by the type of aura with some requiring attentive treatment." | 1.56 | Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine. ( Daida, A; Go, S; Ishida, Y; Kashiwagi, Y; Kasuga, A; Kawashima, H; Morichi, S; Morishita, N; Nagao, R; Oana, S; Suganami, Y; Suzuki, S; Takeshita, M; Tomoko, T; Yamanaka, G, 2020) |
| "When ibuprofen alone was administered, pain scores equal to or lower than 5/10 were associated with the greatest sensitivity and specificity for discharge." | 1.46 | Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine. ( Aravamuthan, BR; Mar, SS; Williams, KG, 2017) |
| "The triggers in the Indian migraine patients are similar to other populations but for dietary factors." | 1.36 | A study of triggers of migraine in India. ( Kalita, J; Misra, UK; Yadav, RK, 2010) |
| "Although migraine is the main chronic headache in childhood and adolescence, it remains extensively misdiagnosed." | 1.31 | [Migraine, misunderstood pathology in children]. ( Annequin, D; Dumas, C; Tourniaire, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.23) | 18.7374 |
| 1990's | 5 (7.04) | 18.2507 |
| 2000's | 30 (42.25) | 29.6817 |
| 2010's | 19 (26.76) | 24.3611 |
| 2020's | 14 (19.72) | 2.80 |
| Authors | Studies |
|---|---|
| Yuan, H | 1 |
| Curran, JG | 1 |
| Keith, SW | 1 |
| Hopkins, MM | 1 |
| Silberstein, SD | 2 |
| Dogruyol, S | 1 |
| Gur, STA | 1 |
| Akbas, I | 1 |
| Kocak, MB | 1 |
| Kocak, AO | 1 |
| Ceylan, M | 1 |
| Tekyol, D | 1 |
| Genizi, J | 1 |
| Lahoud, D | 1 |
| Cohen, R | 1 |
| Löllgen, RM | 1 |
| Babl, FE | 1 |
| Mackay, MT | 1 |
| Hill, A | 1 |
| Palmer, GM | 1 |
| Suda, C | 1 |
| Kondo, Y | 1 |
| Kanaoka, K | 1 |
| Watanabe, J | 1 |
| Lau, CI | 1 |
| Wang, YF | 1 |
| Chang, WJ | 1 |
| Ho, MP | 1 |
| Goadsby, P | 1 |
| Ruiz de la Torre, E | 1 |
| Constantin, L | 1 |
| Amand, C | 1 |
| Ruscheweyh, R | 1 |
| Dresler, T | 1 |
| Förderreuther, S | 1 |
| Gaul, C | 3 |
| Gossrau, G | 1 |
| Jürgens, TP | 1 |
| Ruschil, V | 1 |
| Straube, A | 1 |
| Scheidt, J | 1 |
| Jamiolkowski, D | 1 |
| Steveling-Klein, E | 1 |
| Scherer Hofmeier, K | 1 |
| Hartmann, K | 1 |
| Pavithra, V | 1 |
| Mishra, D | 1 |
| Behera, S | 1 |
| Juneja, M | 1 |
| Yamanaka, G | 1 |
| Go, S | 1 |
| Morichi, S | 1 |
| Takeshita, M | 1 |
| Morishita, N | 1 |
| Suzuki, S | 1 |
| Tomoko, T | 1 |
| Kasuga, A | 1 |
| Daida, A | 1 |
| Ishida, Y | 1 |
| Oana, S | 1 |
| Suganami, Y | 1 |
| Nagao, R | 1 |
| Kashiwagi, Y | 1 |
| Kawashima, H | 1 |
| Panda, PK | 1 |
| Sharawat, IK | 1 |
| Singh, S | 1 |
| Chakrabarty, B | 1 |
| Jeric, M | 1 |
| Surjan, N | 1 |
| Jelicic Kadic, A | 1 |
| Riva, N | 1 |
| Puljak, L | 1 |
| Lipton, RB | 4 |
| Diener, HC | 2 |
| Robbins, MS | 1 |
| Garas, SY | 1 |
| Patel, K | 1 |
| Diener, H- | 1 |
| Borchard-Tuch, C | 1 |
| Rabbie, R | 2 |
| Derry, S | 2 |
| Moore, RA | 2 |
| Gallelli, L | 1 |
| Avenoso, T | 1 |
| Falcone, D | 1 |
| Palleria, C | 1 |
| Peltrone, F | 1 |
| Esposito, M | 1 |
| De Sarro, G | 1 |
| Carotenuto, M | 1 |
| Guidetti, V | 1 |
| Goldstein, J | 2 |
| Hagen, M | 1 |
| Gold, M | 1 |
| Aravamuthan, BR | 1 |
| Mar, SS | 1 |
| Williams, KG | 1 |
| Richer, L | 1 |
| Billinghurst, L | 1 |
| Linsdell, MA | 1 |
| Russell, K | 1 |
| Vandermeer, B | 1 |
| Crumley, ET | 1 |
| Durec, T | 1 |
| Klassen, TP | 1 |
| Hartling, L | 1 |
| Xu, H | 1 |
| Han, W | 1 |
| Wang, J | 1 |
| Li, M | 1 |
| Hofmann, R | 1 |
| Sethi, NK | 1 |
| Yadav, RK | 3 |
| Kalita, J | 4 |
| Misra, UK | 4 |
| D'Arcy, Y | 1 |
| DeLeon, D | 1 |
| Douglas, C | 1 |
| Schwiebert, P | 1 |
| Manzano, S | 1 |
| Doyon-Trottier, E | 1 |
| Bailey, B | 1 |
| McQuay, HJ | 1 |
| Hewitt, DJ | 1 |
| Martin, V | 1 |
| Brandes, J | 1 |
| Ceesay, P | 1 |
| Gottwald, R | 1 |
| Schaefer, E | 1 |
| Lines, C | 2 |
| Ho, TW | 1 |
| Eismann, R | 1 |
| Wohlrab, J | 1 |
| Marsch, WC | 1 |
| Fiedler, E | 1 |
| O'Brien, HL | 1 |
| Kabbouche, MA | 1 |
| Hershey, AD | 1 |
| Jiménez Caballero, PE | 1 |
| Calle Escobar, ML | 1 |
| Portilla Cuenca, JC | 1 |
| Casado Naranjo, I | 1 |
| Lewis, DW | 1 |
| Kellstein, D | 1 |
| Dahl, G | 1 |
| Burke, B | 1 |
| Frank, LM | 1 |
| Toor, S | 1 |
| Northam, RS | 1 |
| White, LW | 1 |
| Lawson, L | 1 |
| Rollins, G | 1 |
| Mao-Draayer, Y | 1 |
| Bingham, P | 1 |
| Croissant, B | 1 |
| Brosi, K | 1 |
| Hermann, D | 1 |
| Mann, K | 1 |
| Bussone, G | 1 |
| de Liano, H | 1 |
| Eikermann, A | 1 |
| Englert, R | 1 |
| Floeter, T | 1 |
| Gallai, V | 1 |
| Göbel, H | 1 |
| Hartung, E | 1 |
| Jimenez, MD | 1 |
| Lange, R | 1 |
| Manzoni, GC | 2 |
| Mueller-Schwefe, G | 1 |
| Nappi, G | 2 |
| Pinessi, L | 1 |
| Prat, J | 1 |
| Puca, FM | 1 |
| Titus, F | 1 |
| Voelker, M | 1 |
| Morillo, LE | 2 |
| Jose, M | 1 |
| Cuvellier, JC | 2 |
| Joriot, S | 2 |
| Auvin, S | 2 |
| Vallée, L | 2 |
| Damen, L | 1 |
| Bruijn, JK | 1 |
| Verhagen, AP | 1 |
| Berger, MY | 1 |
| Passchier, J | 1 |
| Koes, BW | 1 |
| Saper, J | 1 |
| Dahlof, C | 1 |
| So, Y | 1 |
| Tfelt-Hansen, P | 1 |
| Malbecq, W | 1 |
| Loeys, T | 1 |
| Barraclough, E | 1 |
| Klipfel, M | 1 |
| Visser, H | 1 |
| Reines, S | 1 |
| Yuen, E | 1 |
| Saper, JR | 1 |
| Ryan, RE | 1 |
| Evers, S | 2 |
| Rahmann, A | 1 |
| Kraemer, C | 1 |
| Kurlemann, G | 1 |
| Debus, O | 1 |
| Husstedt, IW | 1 |
| Frese, A | 1 |
| Haag, G | 1 |
| Kornblau, DH | 1 |
| Silver, S | 1 |
| Gano, D | 1 |
| Gerretsen, P | 1 |
| Suthisisang, C | 1 |
| Poolsup, N | 1 |
| Kittikulsuth, W | 1 |
| Pudchakan, P | 1 |
| Wiwatpanich, P | 1 |
| Pearce, I | 1 |
| Frank, GJ | 1 |
| Pearce, JM | 1 |
| Hoffman, LM | 1 |
| Ellis, GL | 1 |
| Delaney, J | 1 |
| DeHart, DA | 1 |
| Owens, A | 1 |
| Hämäläinen, ML | 1 |
| Hoppu, K | 1 |
| Valkeila, E | 1 |
| Santavuori, P | 1 |
| Sandrini, G | 1 |
| Franchini, S | 1 |
| Lanfranchi, S | 1 |
| Granella, F | 1 |
| Kellstein, DE | 1 |
| Geetha, R | 1 |
| Koronkiewicz, K | 1 |
| Evans, FT | 1 |
| Stewart, WF | 1 |
| Wilkes, K | 1 |
| Furey, SA | 1 |
| Subramanian, T | 1 |
| Cooper, SA | 1 |
| Annequin, D | 1 |
| Tourniaire, B | 1 |
| Dumas, C | 1 |
| Pothmann, R | 1 |
| Uberall, M | 1 |
| Naumann, E | 1 |
| Gerber, WD | 1 |
| Kolar, KR | 1 |
| Fisher, W | 1 |
| Gordon, V | 1 |
| Barnett, R | 1 |
| Kloster, R | 1 |
| Nestvold, K | 1 |
| Vilming, ST | 1 |
| Havanka-Kanniainen, H | 1 |
| McGrath, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack[NCT01230411] | Phase 4 | 44 participants (Actual) | Interventional | 2011-06-30 | Completed | ||
| Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649] | Phase 4 | 62 participants (Actual) | Interventional | 2020-02-10 | Completed | ||
| The Effect of Daylight Saving Time Transitions on Sleep and Migraine Headaches.[NCT05742191] | 50 participants (Anticipated) | Observational | 2023-02-06 | Recruiting | |||
| A Phase IIa Randomized, Double-Blind, Parallel-Group, Placebo and Active-Controlled, Clinical Trial to Study the Efficacy and Safety of MK0974 Co-administered With Ibuprofen or Acetaminophen in Patients With Migraine With or Without Aura[NCT00758836] | Phase 2 | 683 participants (Actual) | Interventional | 2008-12-03 | Completed | ||
| The Comparison of the Effectiveness of Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack in Emergency Service[NCT01730326] | Phase 4 | 200 participants (Actual) | Interventional | 2012-03-31 | Completed | ||
| Evaluation of Efficacy and Safety of add-on Alpha-lipoic Acid on Migraine Prophylaxis in Adolescent Population: A Randomized Controlled Trial[NCT04064814] | Phase 4 | 60 participants (Actual) | Interventional | 2019-09-14 | Completed | ||
| Effects of Myofascial Trigger Points Therapy in Migraine.[NCT05646160] | 100 participants (Anticipated) | Interventional | 2018-01-15 | Recruiting | |||
| A Randomized Double Blinded Study Comparing Use of Prochlorperazine Versus Prochlorperazine and Ketorolac in the Treatment of Pediatric Migraine in the Emergency Department[NCT01534806] | Phase 4 | 0 participants (Actual) | Interventional | 2012-01-31 | Withdrawn (stopped due to Drug is backordered;) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Comparison of proportion of subjects in each treatment group (active treatment and placebo) who have pain relief at 2 hours after the completion of the double-blind treatment infusion. Pain relief is defined as a reduction in headache pain level from severe or moderate decreased to mild or headache-free, respectively. (NCT01230411)
Timeframe: 2 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Placebo | 10 |
| Ibuprofen | 17 |
(NCT03951649)
Timeframe: 7 days
| Intervention | days (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 4 |
(NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 7 |
| Oral Acetaminophen/Caffeine Group | 2 |
Other: Pain at injection site (NCT03951649)
Timeframe: 7 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 2 |
(NCT03951649)
Timeframe: 7 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 0 |
| Oral Acetaminophen/Caffeine Group | 0 |
(NCT03951649)
Timeframe: 4 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 9 |
| Oral Acetaminophen/Caffeine Group | 14 |
(NCT03951649)
Timeframe: 5 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 4 |
| Oral Acetaminophen/Caffeine Group | 2 |
Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 1 |
(NCT03951649)
Timeframe: 120 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 5 |
| Oral Acetaminophen/Caffeine Group | 5 |
Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min
| Intervention | Participants (Count of Participants) |
|---|---|
| Occipital Nerve Block | 20 |
| Oral Acetaminophen/Caffeine Group | 16 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 3 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 180min
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6 |
| Oral Acetaminophen/Caffeine Group | 4 |
"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 2 hrs
| Intervention | score on a scale (Median) |
|---|---|
| Occipital Nerve Block | 6.0 |
| Oral Acetaminophen/Caffeine Group | 6.5 |
An adverse event is any unfavorable and unintended change in the structure, function, or chemistry of the body whether or not considered related to the study treatment. (NCT00758836)
Timeframe: Up to 14 days post-dose
| Intervention | participants (Number) |
|---|---|
| Placebo | 31 |
| Telcagepant 280 mg +Ibuprofen 400 mg | 46 |
| Telcagepant 280 mg +APAP 1000 mg | 46 |
| Telcagepant 280 mg | 37 |
An adverse event is any unfavorable and unintended change in the structure, function, or chemistry of the body whether or not considered related to the study treatment. (NCT00758836)
Timeframe: Up to 48 hours post-dose
| Intervention | Participants (Number) |
|---|---|
| Placebo | 27 |
| Telcagepant 280 mg +Ibuprofen 400 mg | 44 |
| Telcagepant 280 mg +APAP 1000 mg | 42 |
| Telcagepant 280 mg | 34 |
Pain severity was rated by the participants in a paper diary by grade; Grade 0 (no pain), Grade 1 (mild pain), Grade 2 (moderate pain), and Grade 3 (severe pain). Pain freedom was defined as a reduction in pain severity from moderate to severe migraine headache (Grade 2 or 3) to no pain (Grade 0). (NCT00758836)
Timeframe: 2 hours post-dose
| Intervention | Percentage of Participants (Number) |
|---|---|
| Placebo | 10.9 |
| Telcagepant 280 mg +Ibuprofen 400 mg | 35.2 |
| Telcagepant 280 mg +APAP 1000 mg | 38.3 |
| Telcagepant 280 mg | 31.2 |
Pain severity was rated by the participants in a paper diary by grade; Grade 0 (no pain), Grade 1 (mild pain), Grade 2 (moderate pain), and Grade 3 (severe pain). Pain relief was defined as a reduction in pain severity from moderate to severe migraine headache (Grade 2 or 3) to mild or none (Grade 1 or 0). (NCT00758836)
Timeframe: 2 hours post-dose
| Intervention | Percentage of Participants (Number) |
|---|---|
| Placebo | 30.6 |
| Telcagepant 280 mg +Ibuprofen 400 mg | 71.0 |
| Telcagepant 280 mg +APAP 1000 mg | 69.9 |
| Telcagepant 280 mg | 65.2 |
21 reviews available for ibuprofen and Migraine Disorders
| Article | Year |
|---|---|
Treatment of acute migraine attacks in children with analgesics on the World Health Organization Essential Medicines List: A systematic review and GRADE evidence synthesis.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Child; Humans; Ibuprofen; Migraine Disorders | 2018 |
Caffeine in the management of patients with headache.
Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan | 2017 |
Topics: Analgesics; Aspirin; Diclofenac; Humans; Ibuprofen; Migraine Disorders; Pyrrolidines; Randomized Con | 2017 |
Ibuprofen with or without an antiemetic for acute migraine headaches in adults.
Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combination; Human | 2013 |
Drugs for the acute treatment of migraine in children and adolescents.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Dihydroergotamine; Humans; Ibuprofen; Mi | 2016 |
Network meta-analysis of migraine disorder treatment by NSAIDs and triptans.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Migraine Disorders; Oxazolidinones; Pyrr | 2016 |
Question: What are the best pharmacological options for treating the symptoms of migraine headaches in children?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Decision Making; Humans; Ibuprofen; Migraine Disorde | 2010 |
Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults.
Topics: Acetaminophen; Adolescent; Adult; Altitude Sickness; Analgesics, Non-Narcotic; Child; Headache; Huma | 2010 |
Ibuprofen with or without an antiemetic for acute migraine headaches in adults.
Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Antiemetics; Drug Therapy, Combination; Human | 2010 |
Red ear syndrome: case report and review of the literature.
Topics: Adult; Analgesics, Non-Narcotic; Ear Diseases; Edema; Erythema; Female; Humans; Hyperhidrosis; Ibupr | 2011 |
Treating pediatric migraine: an expert opinion.
Topics: Acetaminophen; Analgesics; Behavior Therapy; Child; Humans; Ibuprofen; Migraine Disorders | 2012 |
Two teenagers with headaches.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Female; Headache; Huma | 2003 |
Migraine headache.
Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Dicl | 2003 |
Migraine headache.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Ergotamine; Humans; Ibuprofen; Indoles; Migrain | 2004 |
[Pharmacologic treatment of acute migraine attack in children].
Topics: Acetaminophen; Acute Disease; Administration, Intranasal; Administration, Oral; Adolescent; Age Fact | 2005 |
Symptomatic treatment of migraine in children: a systematic review of medication trials.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Controlled Clinical Tr | 2005 |
[Self-medication of migraine and headache].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine; | 2006 |
Acute treatment of paediatric migraine: a meta-analysis of efficacy.
Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; | 2008 |
Efficacy of low-dose ibuprofen in acute migraine treatment: systematic review and meta-analysis.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double-Bli | 2007 |
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psyc | 2002 |
"Nurse, my head hurts": a review of childhood headaches.
Topics: Acetaminophen; Adolescent; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Emergenci | 2001 |
21 trials available for ibuprofen and Migraine Disorders
| Article | Year |
|---|---|
Intravenous ibuprofen for acute treatment of migraine: A double-blind, randomized, placebo-controlled pilot study.
Topics: Acute Disease; Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-B | 2021 |
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department: A randomized clinical trial.
Topics: Double-Blind Method; Emergency Service, Hospital; Headache; Humans; Ibuprofen; Migraine Disorders; P | 2022 |
Paracetamol versus Ibuprofen for the Acute Treatment of Migraine Headache in Children: A Blinded Randomized Controlled Trial.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Double-Blind Method; Female; Humans; Ibuprofen; Indi | 2020 |
Effects of acetaminophen and ibuprofen in children with migraine receiving preventive treatment with magnesium.
Topics: Acetaminophen; Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Ibupr | 2014 |
Results of a multicenter, double-blind, randomized, parallel-group, placebo-controlled, single-dose study comparing the fixed combination of acetaminophen, acetylsalicylic acid, and caffeine with ibuprofen for acute treatment of patients with severe migra
Topics: Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Double-Blind Method; Drug Therapy, Combination; | 2014 |
A comparison of migraine patients with and without allodynic symptoms.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Asian People; Double-Blind Method; Femal | 2009 |
Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcitonin Gene | 2011 |
Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcitonin Gene | 2011 |
Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcitonin Gene | 2011 |
Randomized controlled study of telcagepant plus ibuprofen or acetaminophen in migraine.
Topics: Acetaminophen; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Azepines; Calcitonin Gene | 2011 |
Children's ibuprofen suspension for the acute treatment of pediatric migraine.
Topics: Acute Disease; Analgesics, Non-Narcotic; Child; Double-Blind Method; Female; Humans; Ibuprofen; Male | 2002 |
Placebo-controlled comparison of effervescent acetylsalicylic acid, sumatriptan and ibuprofen in the treatment of migraine attacks.
Topics: Adult; Aspirin; Chemistry, Pharmaceutical; Chi-Square Distribution; Confidence Intervals; Cross-Over | 2004 |
Rofecoxib versus ibuprofen for acute treatment of migraine: a randomised placebo controlled trial.
Topics: Acute Disease; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; | 2004 |
Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dizziness; Dose-Response Relationship | 2006 |
Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Ca | 2006 |
Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.
Topics: Administration, Oral; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Double-Blind Metho | 2006 |
Rizatriptan vs. ibuprofen in migraine: a randomised placebo-controlled trial.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Male; Migr | 2007 |
Ibuprofen compared with paracetamol in migraine.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Male | 1983 |
The efficacy of metoclopramide in the treatment of migraine headache.
Topics: Adolescent; Adult; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Humans; Ibuprofen | 1993 |
Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study.
Topics: Acetaminophen; Administration, Oral; Adolescent; Child; Child, Preschool; Cross-Over Studies; Double | 1997 |
Effectiveness of ibuprofen-arginine in the treatment of acute migraine attacks.
Topics: Acute Disease; Administration, Oral; Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Ster | 1998 |
Evaluation of a novel solubilized formulation of ibuprofen in the treatment of migraine headache: a randomized, double-blind, placebo-controlled, dose-ranging study.
Topics: Adult; Analgesics, Non-Narcotic; Analysis of Variance; Double-Blind Method; Female; Gels; Humans; Ib | 2000 |
A double-blind study of ibuprofen versus placebo in the treatment of acute migraine attacks.
Topics: Acute Disease; Adult; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Migraine Di | 1992 |
Treatment of acute migraine attack: ibuprofen and placebo compared.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Male; M | 1989 |
29 other studies available for ibuprofen and Migraine Disorders
| Article | Year |
|---|---|
Migraine abortive treatment in children and adolescents in Israel.
Topics: Acetaminophen; Adolescent; Child; Dipyrone; Female; Headache; Humans; Ibuprofen; Israel; Male; Migra | 2022 |
Intravenous chlorpromazine for acute paediatric migraine.
Topics: Acetaminophen; Child; Chlorpromazine; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disor | 2022 |
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department.
Topics: Anticonvulsants; Double-Blind Method; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disor | 2022 |
2022 Taiwan Guidelines for Acute Treatment of Migraine.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Caffeine; Calcitonin G | 2022 |
Intravenous ibuprofen versus sodium valproate in acute migraine attacks in the emergency department.
Topics: Anticonvulsants; Double-Blind Method; Emergency Service, Hospital; Humans; Ibuprofen; Migraine Disor | 2023 |
Social Media Listening and Digital Profiling Study of People With Headache and Migraine: Retrospective Infodemiology Study.
Topics: Headache; Humans; Ibuprofen; Infodemiology; Migraine Disorders; Retrospective Studies; Social Media | 2023 |
What do patients' efficacy and tolerability ratings of acute migraine medication tell us? Cross-sectional data from the DMKG Headache Registry.
Topics: Adult; Analgesics, Non-Narcotic; Cross-Sectional Studies; Female; Headache; Humans; Ibuprofen; Middl | 2023 |
Multilocular bullous fixed drug eruption elicited by paracetamol and migraine attacks, but not by paracetamol alone.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blister; Dr | 2020 |
Clinical Features and Burden Scores in Japanese Pediatric Migraines With Brainstem Aura, Hemiplegic Migraine, and Retinal Migraine.
Topics: Adolescent; Brain; Brain Stem; Child; Cost of Illness; Domperidone; Electrocardiography; Electroence | 2020 |
Paracetamol versus Ibuprofen for the Acute Treatment of Migraine Headache in Children: A Blinded Randomized Controlled Trial - Correspondence.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Humans; Ibuprofen; Migraine Disorders | 2021 |
Acetaminophen or Ibuprofen: A Riddle Worth Solving in an Acute Attack of Pediatric Migraine.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Humans; Ibuprofen; Migraine Disorders | 2020 |
[In process].
Topics: Adolescent; Adrenergic beta-Antagonists; Age Factors; Analgesics; Behavior Therapy; Child; Flunarizi | 2016 |
[Aspirin for migraine in pregnancy. This recommendation seems questionable].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraindications; Female; Humans; Ibuprofen; Infa | 2013 |
Factors Associated With Discharge After Initial Emergency Treatment of Pediatric Migraine.
Topics: Administration, Intranasal; Administration, Intravenous; Administration, Oral; Adolescent; Analgesic | 2017 |
More to be said on "Triptans vs other drugs for acute migraine. Are there differences in efficacy?".
Topics: Acetaminophen; Analgesics; Aspirin; Dosage Forms; Humans; Ibuprofen; Migraine Disorders; Randomized | 2009 |
Excessive acute migraine medication use and migraine progression.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Barbiturates | 2009 |
A study of triggers of migraine in India.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diet; Disability Evaluation; Eating; Fem | 2010 |
Going the distance. New pain treatment provide longer stronger relief.
Topics: Administration, Cutaneous; Analgesics; Carbazoles; Delayed-Action Preparations; Drug Combinations; D | 2007 |
[Migraine triggered by laughing as a form of presentation of a Chiari type I malformation].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arnold-Chiari Malformation; Brain; Humans; Ibuprofen | 2013 |
Migraine sufferers are not seeking nor receiving guideline-based care.
Topics: Acetaminophen; Analgesics; Barbiturates; Caffeine; Drug Combinations; Drug Prescriptions; Female; He | 2002 |
[More than six billions Euro costs due to illness days. Migraine therapy counts].
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Aspirin; Cost of Ill | 2003 |
[Drug-induced headache and pain reduction medication with amitriptyline in an 11-year old pupil].
Topics: Amitriptyline; Analgesics; Antihypertensive Agents; Aspirin; Child; Dipyrone; Headache Disorders; Hu | 2004 |
[Medical treatment of migraine attacks in the child].
Topics: Acetaminophen; Age Factors; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Child; Ergot Alkalo | 2006 |
Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen.
Topics: Analgesics, Non-Narcotic; Drug Combinations; Drug Costs; Humans; Ibuprofen; Migraine Disorders; Nonp | 2007 |
Ibuprofen: new indication. Migraine attacks: don't begin with 400 mg!
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Rela | 2007 |
Migraine.
Topics: Acetaminophen; Adult; Aspirin; Child; Diphenhydramine; Histamine H1 Antagonists; Humans; Ibuprofen; | 1993 |
[Migraine, misunderstood pathology in children].
Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Child; Child Welfare; Diagnosis, Differenti | 2000 |
Migraine in women.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Codeine; Contraindications; Female; Hum | 2002 |
Migraine treatment.
Topics: Child; Humans; Ibuprofen; Migraine Disorders | 1989 |