Page last updated: 2024-10-28

ibuprofen and Middle Ear Inflammation

ibuprofen has been researched along with Middle Ear Inflammation in 19 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."9.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."9.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."9.08A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."8.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"The impact of ibuprofen combined with amoxicillin or erythromycin for therapy of penicillin-resistant pneumococcal acute otitis media (AOM) was evaluated in a gerbil model."7.73Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin. ( Cenjor, C; del Prado, G; Fernández-Roblas, R; Gracia, M; Huelves, L; Martínez-Marín, C; Ponte, C; Rodríguez-Cerrato, V; Soriano, F, 2006)
"In this study, the efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion, presence of mucosal inflammation, and modulation of biochemical markers."7.69Effect of ibuprofen treatment during experimental acute otitis media. ( Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Swarts, JD, 1995)
"The efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion and resolution of mucosal inflammation."7.69Treatment of experimental acute otitis media with ibuprofen and ampicillin. ( Alper, C; Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Jaffe, R, 1995)
"This randomized study suggests that topical 1% lidocaine ear drops with paracetamol or ibuprofen seems to provide effective and rapid relief for children presenting with ear pain attributed to AOM."5.51The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media. ( Alabaz, D; Albayrak, E; Bedir, T; Bozdemir, ŞE; Büyükcam, A; Çelebi, S; Çiftçi, E; İlarslan, EÇ; Kara, A; Kara, M; Kara, SS; Kara, TT; Karakaşlılar, S; Karbuz, A; Kaya, C; Öz, FN; Özdemir, H; Sali, E; Somer, A; Sönmez, G; Sütçü, M; Tezer, H, 2022)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."5.41Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; de Sévaux, JLH; Hay, AD; Little, P; Lutje, V; Schilder, AG; van de Pol, AC; Venekamp, RP, 2023)
"Acetaminophen alone may not be as effective in reducing pain-related physiological and behavioral changes as acetaminophen plus codeine or ibuprofen plus midazolam during diagnostic tympanocentesis."5.15Pain management in young children undergoing diagnostic tympanocentesis. ( Chandra, A; Colborn, DK; Hoberman, A; Hooper, EG; Kurs-Lasky, M; Reis, EC; Rockette, HE; Shaikh, N, 2011)
"Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized, double-blind, multicentre (4 centres) controlled trial designed to assess the efficacy and safety of ibuprofen (IBU) in the treatment of 1 to 6 year-old children with otoscopically proven acute otitis media (AOM), either unilateral or bilateral."5.08A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. ( Bertin, L; d'Athis, P; Debregeas, B; Duhamel, JF; Guillot, M; Lasfargues, G; Marsac, A; Maudelonde, C; Olive, G; Pons, G, 1996)
"Our primary objective was to assess the effectiveness of paracetamol (acetaminophen) or NSAIDs, alone or combined, compared with placebo or no treatment in relieving pain in children with AOM."4.93Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children. ( Damoiseaux, RA; Hay, AD; Little, P; Schilder, AG; Sjoukes, A; van de Pol, AC; Venekamp, RP, 2016)
"The impact of ibuprofen combined with amoxicillin or erythromycin for therapy of penicillin-resistant pneumococcal acute otitis media (AOM) was evaluated in a gerbil model."3.73Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin. ( Cenjor, C; del Prado, G; Fernández-Roblas, R; Gracia, M; Huelves, L; Martínez-Marín, C; Ponte, C; Rodríguez-Cerrato, V; Soriano, F, 2006)
"In this study, the efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion, presence of mucosal inflammation, and modulation of biochemical markers."3.69Effect of ibuprofen treatment during experimental acute otitis media. ( Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Swarts, JD, 1995)
"The efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion and resolution of mucosal inflammation."3.69Treatment of experimental acute otitis media with ibuprofen and ampicillin. ( Alper, C; Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Jaffe, R, 1995)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (15.79)18.2507
2000's6 (31.58)29.6817
2010's7 (36.84)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Kara, A1
Büyükcam, A1
Sütçü, M1
Sali, E1
Bozdemir, ŞE1
Kara, M1
İlarslan, EÇ1
Kaya, C1
Karakaşlılar, S1
Sönmez, G1
Kara, SS1
Bedir, T1
Albayrak, E1
Kara, TT1
Çelebi, S1
Öz, FN1
Karbuz, A1
Somer, A1
Alabaz, D1
Tezer, H1
Özdemir, H1
Çiftçi, E1
de Sévaux, JLH1
Damoiseaux, RA2
van de Pol, AC3
Lutje, V1
Hay, AD2
Little, P2
Schilder, AG2
Venekamp, RP3
Kmietowicz, Z1
McHale, B1
Badenhorst, CD1
Low, C1
Blundell, D1
van Uum, RT1
Sjoukes, A2
de Wit, GA1
Schilder, AGM1
Damoiseaux, RAMJ1
Siddiq, S1
Grainger, J1
Bliss-Holtz, J1
Shaikh, N1
Hoberman, A1
Kurs-Lasky, M1
Rockette, HE1
Chandra, A1
Colborn, DK1
Hooper, EG1
Reis, EC1
Worrall, G1
O'Neill, P4
Roberts, T2
del Prado, G1
Martínez-Marín, C1
Huelves, L1
Gracia, M1
Rodríguez-Cerrato, V1
Fernández-Roblas, R1
Ponte, C1
Cenjor, C1
Soriano, F1
Bradley Stevenson, C1
Diven, WF2
Evans, RW2
Swarts, JD1
Burckart, GJ2
Doyle, WJ2
Alper, C1
Jaffe, R1
Bertin, L1
Pons, G1
d'Athis, P1
Duhamel, JF1
Maudelonde, C1
Lasfargues, G1
Guillot, M1
Marsac, A1
Debregeas, B1
Olive, G1

Reviews

7 reviews available for ibuprofen and Middle Ear Inflammation

ArticleYear
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2023, 08-18, Volume: 8

    Topics: Acetaminophen; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Fever; Humans;

2023
The diagnosis and management of acute otitis media: American Academy of Pediatrics Guidelines 2013.
    Archives of disease in childhood. Education and practice edition, 2015, Volume: 100, Issue:4

    Topics: Academies and Institutes; Amoxicillin; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child

2015
Paracetamol (acetaminophen) or non-steroidal anti-inflammatory drugs, alone or combined, for pain relief in acute otitis media in children.
    The Cochrane database of systematic reviews, 2016, 12-15, Volume: 12

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2016
Acute otitis media.
    Clinical evidence, 2002, Issue:7

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;

2002
Acute otitis media.
    Clinical evidence, 2002, Issue:8

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Chewing Gum; Child, Preschool; Female; Humans;

2002
Acute otitis media in children.
    Clinical evidence, 2005, Issue:13

    Topics: Acetaminophen; Acute Disease; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child;

2005
Otitis media in children (acute).
    Clinical evidence, 2006, Issue:15

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Age

2006

Trials

5 trials available for ibuprofen and Middle Ear Inflammation

ArticleYear
The effectiveness of topical 1% lidocaine with systemic oral analgesics for ear pain with acute otitis media.
    International journal of pediatric otorhinolaryngology, 2022, Volume: 156

    Topics: Acetaminophen; Acute Disease; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Earache; H

2022
Do children undergoing bilateral myringotomy with placement of ventilating tubes benefit from pre-operative analgesia? A double-blinded, randomised, placebo-controlled trial.
    The Journal of laryngology and otology, 2018, Volume: 132, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Child; Child, Preschool; Double-Blind Method; F

2018
Optimising pain management in children with acute otitis media through a primary care-based multifaceted educational intervention: study protocol for a cluster randomised controlled trial.
    Trials, 2018, Sep-17, Volume: 19, Issue:1

    Topics: Acetaminophen; Acute Pain; Age Factors; Analgesics, Non-Narcotic; Child; Child, Preschool; Cost-Bene

2018
Pain management in young children undergoing diagnostic tympanocentesis.
    Clinical pediatrics, 2011, Volume: 50, Issue:3

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Analgesics, Opioid; Biopsy, Fine-Needle; Chi

2011
A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children.
    Fundamental & clinical pharmacology, 1996, Volume: 10, Issue:4

    Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chi

1996

Other Studies

7 other studies available for ibuprofen and Middle Ear Inflammation

ArticleYear
Drugs for acute otitis media in children.
    The Medical letter on drugs and therapeutics, 2022, Feb-07, Volume: 64, Issue:1643

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agent

2022
Most cases of otitis media should not be treated with antibiotics, says NICE.
    BMJ (Clinical research ed.), 2017, 09-21, Volume: 358

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroi

2017
Defunct gadgets and changing times.
    Issues in comprehensive pediatric nursing, 2009, Volume: 32, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Amoxicillin; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Ster

2009
Acute earache.
    Canadian family physician Medecin de famille canadien, 2011, Volume: 57, Issue:9

    Topics: Acute Disease; Amoxicillin; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child, Preschool; Earac

2011
Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin.
    Pediatric research, 2006, Volume: 60, Issue:5

    Topics: Amoxicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Child; Disease

2006
Effect of ibuprofen treatment during experimental acute otitis media.
    Auris, nasus, larynx, 1995, Volume: 22, Issue:2

    Topics: Acute Disease; Ampicillin; Animals; Chinchilla; Drug Therapy, Combination; Ear, Middle; Fatty Acids,

1995
Treatment of experimental acute otitis media with ibuprofen and ampicillin.
    International journal of pediatric otorhinolaryngology, 1995, Volume: 33, Issue:2

    Topics: Acute Disease; Ampicillin; Animals; Chinchilla; Disease Models, Animal; Drug Therapy, Combination; E

1995