Page last updated: 2024-10-28

ibuprofen and Kidney Diseases

ibuprofen has been researched along with Kidney Diseases in 35 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen."9.22Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. ( Bao, W; Beckerman, B; Berger, MF; Borer, JS; Gaffney, M; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2016)
" We examined whether delayed administration of the nonsteroidal anti-inflammatory agent ibuprofen only or combined with antibiotics suppresses renal scarring in a model of ascending pyelonephritis in rats."5.30Ibuprofen combined with antibiotics suppresses renal scarring due to ascending pyelonephritis in rats. ( Anderson, AE; Franco, I; Hom, D; Huang, A; Kushner, L; Palmer, LS, 1999)
"To determine the relative risks of cardiovascular (CV), gastrointestinal (GI), and renal adverse events during long-term treatment with celecoxib, compared with ibuprofen and naproxen, in patients with osteoarthritis (OA) and patients with rheumatoid arthritis (RA)."5.27Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis: A Randomized Clinical Trial. ( Bao, W; Berger, MF; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2018)
"Patients who required NSAIDs for osteoarthritis or rheumatoid arthritis and were at increased cardiovascular risk were randomly assigned to receive celecoxib, ibuprofen, or naproxen."5.22Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis. ( Bao, W; Beckerman, B; Berger, MF; Borer, JS; Gaffney, M; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2016)
"This study aims to determine whether or not treatment of preterm neonates with PDA using IV ibuprofen can impair renal function and in what range of birth weights and gestational ages the risk of major renal side-effects due to ibuprofen is highest."5.17Treatment of patent ductus arteriosus (PDA) using ibuprofen: renal side-effects in VLBW and ELBW newborns. ( Bagnoli, F; Casucci, M; Messina, G; Mori, A; Rossetti, A; Tomasini, B, 2013)
" Children with a febrile illness were enrolled from outpatient pediatric and family medicine practices and randomly assigned to receive either acetaminophen suspension or one of two dosages of ibuprofen suspension (5 mg/kg or 10 mg/kg) for fever control."5.08Renal function after short-term ibuprofen use in infants and children. ( Lesko, SM; Mitchell, AA, 1997)
"Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis."4.80Celecoxib clinical profile. ( Tive, L, 2000)
"Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness."3.66An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982)
" Documentation is derived from clinical trials, post-marketing surveillance, special studies, and spontaneous reports of adverse drug reactions from foreign countries."2.66Worldwide safety experience with diclofenac. ( Catalano, MA, 1986)
"Since its introduction in the United States in 1974, ibuprofen (Motrin, Upjohn) has been shown to be safe and effective for the treatment of pain, dysmenorrhea, inflammation, and fever."2.65Safety profile: fifteen years of clinical experience with ibuprofen. ( Royer, GL; Seckman, CE; Welshman, IR, 1984)
" Although effective, these agents can be associated with adverse effects that may limit their use in some people."2.58Cardiorenal Safety of OTC Analgesics. ( Angiolillo, DJ; Davidson, MH; Kloner, RA; White, WB, 2018)
"Ibuprofen has recently been introduced as over-the-counter drug in several countries."2.38Ibuprofen as an over-the-counter drug: is there a risk for renal injury? ( Brune, K; Goerig, M; Luft, FC; Mann, JF, 1993)
" These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model."1.43Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy. ( Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF, 2016)
"Each ibuprofen-treated infant was matched to two controls."1.36The renal adverse effects of ibuprofen are not mediated by AQP2 water channels. ( Aperia, A; Hascoët, JM; Vieux, R; Zelenina, M, 2010)
" We examined whether delayed administration of the nonsteroidal anti-inflammatory agent ibuprofen only or combined with antibiotics suppresses renal scarring in a model of ascending pyelonephritis in rats."1.30Ibuprofen combined with antibiotics suppresses renal scarring due to ascending pyelonephritis in rats. ( Anderson, AE; Franco, I; Hom, D; Huang, A; Kushner, L; Palmer, LS, 1999)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19909 (25.71)18.7374
1990's9 (25.71)18.2507
2000's6 (17.14)29.6817
2010's10 (28.57)24.3611
2020's1 (2.86)2.80

Authors

AuthorsStudies
Avdeef, A1
Tam, KY1
Sridharan, K1
Al Jufairi, M1
Al Segai, O1
Al Ansari, E1
Hashem Ahmed, H1
Husain Shaban, G1
Malalla, Z1
Al Marzooq, R1
Al Madhoob, A1
Saeed Tabbara, K1
Solomon, DH2
Husni, ME2
Wolski, KE2
Wisniewski, LM2
Borer, JS2
Graham, DY2
Libby, P2
Lincoff, AM2
Lüscher, TF2
Menon, V2
Yeomans, ND2
Wang, Q2
Bao, W2
Berger, MF2
Nissen, SE2
White, WB1
Kloner, RA1
Angiolillo, DJ1
Davidson, MH1
Awad, DS1
Ali, RM1
Mhaidat, NM1
Shotar, AM1
Duim, AR1
Rokx, C1
van Gorp, EC1
Rijnders, BJ1
Moro, MG1
Sanchez, PK1
Gevert, MV1
Baller, EM1
Tostes, AF1
Lupepsa, AC1
Baglie, S1
Franco, GC1
Ruschitzka, F1
Gaffney, M1
Beckerman, B1
Vieux, R1
Zelenina, M1
Aperia, A1
Hascoët, JM1
Sourbron, S1
Bagnoli, F1
Rossetti, A1
Messina, G1
Mori, A1
Casucci, M1
Tomasini, B1
Ackerman, Z1
Cominelli, F1
Reynolds, TB1
Guignard, JP1
Ulinski, T1
Bensman, A1
Singh, H1
Agodoa, LY1
Francis, ME1
Eggers, PW1
Royer, GL1
Seckman, CE1
Welshman, IR1
Cinotti, GA1
Bender, WL1
Whelton, A1
Beschorner, WE1
Darwish, MO1
Hall-Craggs, M1
Solez, K1
Mikulaschek, WM1
Carter, ER1
Moffitt, DR1
Rudy, AC1
Knight, PM1
Brater, DC2
Hall, SD1
Fullerton, T1
Sica, DA1
Blum, RA1
Mann, JF1
Goerig, M1
Brune, K1
Luft, FC1
Lesko, SM1
Mitchell, AA1
Villar, D1
Buck, WB1
Gonzalez, JM1
Huang, A1
Palmer, LS1
Hom, D1
Anderson, AE1
Kushner, L1
Franco, I1
Tive, L1
Proctor, RA1
Kunin, CM1
Murray, MD1
Tierney, WM1
Hui, SL1
McDonald, CJ1
Beck, RR1
Abel, FL1
Papadakis, E1
Schlegel, SI1
Paulus, HE1
Catalano, MA1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen[NCT00346216]Phase 424,081 participants (Actual)Interventional2006-10-04Completed
Single Dose Oral Celecoxib (With or Without Acetaminophen) for Acute Post-operative Pain Following Impacted Third Molar Surgery.[NCT04790812]Phase 4100 participants (Anticipated)Interventional2021-04-22Recruiting
Use of a Self-Guided Mindfulness Mobile Application to Improve Pain Outcomes in Individuals With Knee Osteoarthritis[NCT03936088]75 participants (Actual)Interventional2019-05-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Patient's Assessment of Arthritis Pain (VAS)

"VAS question How much pain do you have was graded on a scale from 0 to 100 with 0 indicating No pain and 100 indicating Worst possible pain." (NCT00346216)
Timeframe: ITT and MITT Population - Baseline to 42 months

,,
InterventionNumber of participants (Mean)
Baseline (ITT) N= 8014, 8001, 7928Change-Baseline to Mon1 (ITT) N=7382, 7379, 7325Change-Baseline to Mon2 (ITT) N=7180, 7090, 7149Change-Baseline to Mon4 (ITT) N=6777, 6696, 6740Change-Baseline to Mon8 (ITT) N=6230, 6137, 6159Change-Baseline to Mon12 (ITT) N=5792, 5696, 5846Change-Baseline to Mon18 (ITT) N=5310, 5181. 5246Change-Baseline to Mon24 (ITT) N=4818, 4776, 4785Change-Baseline to Mon30 (ITT) N=4140, 4069, 4086Change-Baseline to Mon36 (ITT) N=3692, 3627, 3635Change-Baseline to Mon42 (ITT) N=3469, 3406, 3439Baseline (MITT) N=7974, 7954, 7894Change-Baseline to Mon1 MITT N=7372, 7367, 7321Change-Baseline to Mon2 MITT N=7170, 7078, 7142Change-Baseline to Mon4 MITT N=6772, 6686, 6732Change-Baseline to Mon8 MITT N=6224, 6128, 6155Change-Baseline to Mon12 MITT N=5787, 5689, 5844Change-Baseline to Mon18 MITT N=5305, 5175, 5242Change-Baseline to Mon24 MITT N=4815, 4769, 4782Change-Baseline to Mon30 MITT N=4139, 4067, 4085Change-Baseline to Mon36 MITT N=3691, 3623, 3635Change-Baseline to Mon42 MITT N=3468, 3404, 3438
Celecoxib54.0-8.2-10.5-11.4-11.7-11.0-11.3-11.3-10.5-10.1-11.454.0-8.2-10.5-11.4-11.7-11.0-11.3-11.4-10.5-10.2-11.4
Ibuprofen54.1-9.0-10.6-11.7-12.1-11.6-11.3-11.5-11.2-10.7-11.154.1-9.0-10.6-11.7-12.1-11.6-11.3-11.5-11.2-10.7-11.1
Naproxen54.1-9.9-11.1-12.3-12.1-11.9-11.7-11.4-11.3-11.6-12.154.1-9.9-11.1-12.3-12.1-11.9-11.7-11.3-11.3-11.6-12.1

The First Occurrence of a Major Adverse Cardiovascular Events (MACE)

MACE defined as the composite of CV death (including hemorrhagic death), non-fatal MI, non-fatal stroke, hospitalization for UA, revascularization or hospitalization for TIA (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months

,,
InterventionPercentage of Participants (Number)
ITT (N = 8072, 8040, 7969)MITT (N = 8030, 7990, 7933)
Celecoxib4.23.1
Ibuprofen4.83.6
Naproxen4.33.2

The First Occurrence of Antiplatelet Trialists Collaboration (APTC) Composite Endpoint, Confirmed by the Clinical Events Committee (CEC).

APTC events are defined as a composite of any of the following events: Death due to CV causes (including cardiac, cerebrovascular, venous thromboembolic, haemorrhagic, other vascular, or unknown cause); Non-fatal MI; Non-fatal stroke (including intracranial hemorrhages, stroke of ischemic or unknown etiology). (NCT00346216)
Timeframe: Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months

,,
InterventionPercentage of Partcipants (Number)
ITT (N = 8072, 8040, 7969)MITT (N = 8030, 7990, 7933)
Celecoxib2.31.7
Ibuprofen2.71.9
Naproxen2.51.8

The First Occurrence of Clinically Significant Gastrointestinal Events (CSGIE)

CSGIE include: Gastroduodenal (GD) hemorrhage, Gastric outlet obstruction, Gastroduodenal, small bowel or large bowel perforation, Large bowel hemorrhage, Small bowel hemorrhage, Acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage, Symptomatic gastric or duodenal ulcer (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months

,,
InterventionPercentage of Participants (Number)
ITT (N = 8072, 8040, 7969)MITT (N = 8030, 7990, 7933)
Celecoxib0.70.3
Ibuprofen0.90.7
Naproxen0.70.7

Reviews

5 reviews available for ibuprofen and Kidney Diseases

ArticleYear
Cardiorenal Safety of OTC Analgesics.
    Journal of cardiovascular pharmacology and therapeutics, 2018, Volume: 23, Issue:2

    Topics: Acetaminophen; Analgesics; Drug Labeling; Heart Diseases; Humans; Ibuprofen; Kidney Diseases; Naprox

2018
Ibuprofen as an over-the-counter drug: is there a risk for renal injury?
    Clinical nephrology, 1993, Volume: 39, Issue:1

    Topics: Acute Kidney Injury; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Rela

1993
Ibuprofen, aspirin and acetaminophen toxicosis and treatment in dogs and cats.
    Veterinary and human toxicology, 1998, Volume: 40, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin;

1998
Celecoxib clinical profile.
    Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec

2000
Non-steroidal and analgesic therapy in the elderly.
    Clinics in rheumatic diseases, 1986, Volume: 12, Issue:1

    Topics: Acetaminophen; Aged; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents; Apazone; Aspirin; Cen

1986

Trials

8 trials available for ibuprofen and Kidney Diseases

ArticleYear
Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis: A Randomized Clinical Trial.
    Arthritis & rheumatology (Hoboken, N.J.), 2018, Volume: 70, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec

2018
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis.
    The New England journal of medicine, 2016, 12-29, Volume: 375, Issue:26

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Cycloo

2016
Treatment of patent ductus arteriosus (PDA) using ibuprofen: renal side-effects in VLBW and ELBW newborns.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:4

    Topics: Birth Weight; Blood Urea Nitrogen; Creatinine; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent;

2013
Effect of misoprostol on ibuprofen-induced renal dysfunction in patients with decompensated cirrhosis: results of a double-blind placebo-controlled parallel group study.
    The American journal of gastroenterology, 2002, Volume: 97, Issue:8

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Glomerular Filtration R

2002
Safety profile: fifteen years of clinical experience with ibuprofen.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Aspirin; Blood Cell Count; Blood Coagulation Tests; Blood Proteins; Centra

1984
Evaluation of the renal protective effect of misoprostol in elderly, osteoarthritic patients at risk for nonsteroidal anti-inflammatory drug-induced renal dysfunction.
    Journal of clinical pharmacology, 1993, Volume: 33, Issue:12

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Double-Blind Method; Female; Glomerular

1993
Renal function after short-term ibuprofen use in infants and children.
    Pediatrics, 1997, Volume: 100, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blood Urea Nitroge

1997
Worldwide safety experience with diclofenac.
    The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B

    Topics: Adult; Aged; Aspirin; Chemical and Drug Induced Liver Injury; Child; Clinical Trials as Topic; Diclo

1986

Other Studies

22 other studies available for ibuprofen and Kidney Diseases

ArticleYear
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
    Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9

    Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological

2010
Biomarkers in neonates receiving potential nephrotoxic drugs.
    European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:22

    Topics: Acetaminophen; Adult; Amikacin; Biomarkers; Cystatins; Female; Furosemide; Gentamicins; Hepatitis A

2021
Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats.
    Pharmaceutical biology, 2014, Volume: 52, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Creatinine; Fr

2014
Proximal tubular dysfunction in a HIV-1 patient with coadministered tenofovir disoproxil-fumarate and ibuprofen.
    AIDS (London, England), 2015, Mar-27, Volume: 29, Issue:6

    Topics: Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; HIV Infections; HIV-1; Humans; Ibuprofen;

2015
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
    Brazilian oral research, 2016, Nov-28, Volume: 30, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cycl

2016
The renal adverse effects of ibuprofen are not mediated by AQP2 water channels.
    Pediatric nephrology (Berlin, Germany), 2010, Volume: 25, Issue:7

    Topics: Analgesics, Non-Narcotic; Aquaporin 2; Birth Weight; Female; Gestational Age; Glomerular Filtration

2010
Compartmental modelling for magnetic resonance renography.
    Zeitschrift fur medizinische Physik, 2010, Volume: 20, Issue:2

    Topics: Adult; Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Computer Simulation; Cyclooxygenase I

2010
The adverse renal effects of prostaglandin-synthesis inhibitors in the newborn rabbit.
    Seminars in perinatology, 2002, Volume: 26, Issue:6

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Cycloox

2002
[Renal complications of non-steroidal anti-inflammatories].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2004, Volume: 11, Issue:7

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Creatinine; Diarrhea;

2004
Treating osteoarthritis in the elderly: should recent data on NSAIDs change our way of practice?
    Southern medical journal, 2007, Volume: 100, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Databases, Factual; Dicl

2007
Association of analgesic use with prevalence of albuminuria and reduced GFR in US adults.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 51, Issue:4

    Topics: Acetaminophen; Adult; Aged; Albuminuria; Analgesics; Aspirin; Cross-Sectional Studies; Female; Glome

2008
Clinical assessment of the renal toxicity of antirheumatic drugs.
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement, 1984, Volume: 7

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dinoprostone

1984
Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate.
    The American journal of medicine, 1984, Volume: 76, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Biopsy; Female; Fenoprofen; Fluoresce

1984
Ibuprofen without a prescription.
    The Medical letter on drugs and therapeutics, 1984, Jul-06, Volume: 26, Issue:665

    Topics: Central Nervous System Diseases; Drug Interactions; Female; Hematologic Diseases; Humans; Ibuprofen;

1984
An update on long-term efficacy and safety with benoxaprofen.
    European journal of rheumatology and inflammation, 1982, Volume: 5, Issue:2

    Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup

1982
Ibuprofen in patients with cystic fibrosis.
    The New England journal of medicine, 1995, Sep-14, Volume: 333, Issue:11

    Topics: Child; Cystic Fibrosis; Humans; Ibuprofen; Kidney Diseases

1995
Enantioselective disposition of ibuprofen in elderly persons with and without renal impairment.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 273, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Female; Humans; Ibuprofen; Kidney Diseases; Male; Stere

1995
I take ibuprofen regularly for my arthritis, but I've heard that it may lead to kidney damage. Can you tell me more?
    Mayo Clinic health letter (English ed.), 1999, Volume: 17, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Humans; Ibuprofen; Kidney Diseases

1999
Ibuprofen combined with antibiotics suppresses renal scarring due to ascending pyelonephritis in rats.
    The Journal of urology, 1999, Volume: 162, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Drug Therapy, Com

1999
Salicylate-induced enzymuria: comparison with other anti-inflammatory agents.
    The American journal of medicine, 1978, Volume: 65, Issue:6

    Topics: Acetaminophen; Acetylglucosaminidase; Adult; Anti-Inflammatory Agents; Aspirin; Gold; Hexosaminidase

1978
Ibuprofen-associated renal impairment in a large general internal medicine practice.
    The American journal of the medical sciences, 1990, Volume: 299, Issue:4

    Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Age Factors; Aged; Analysis of Variance; Fema

1990
Influence of ibuprofen on renal function in acutely endotoxemic dogs.
    Circulatory shock, 1989, Volume: 28, Issue:1

    Topics: Animals; Blood Glucose; Dogs; Endotoxins; Ibuprofen; Kidney Diseases; Kidney Function Tests; Male; S

1989