Page last updated: 2024-10-28

ibuprofen and Joint Pain

ibuprofen has been researched along with Joint Pain in 25 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"To investigate short-term efficacy and safety of a novel lipid ibuprofen formulation 1200 mg/day compared with standard ibuprofen 1200 mg/day and 2400 mg/day in episodic knee arthralgia/flaring pain."9.24A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study. ( Bierma-Zeinstra, SMA; Brew, J; Conaghan, PG; Kilbourn, A; Stoner, K; Wilson, R, 2017)
"To study the effect of Lanconone® (1000 mg) on acute pain on exertion as compared to the standard of care, Ibuprofen (400 mg)."9.22A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain. ( Girandola, RN; Loullis, CC; Srivastava, S, 2016)
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains."9.12Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006)
"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken."8.81Glucosamine therapy compared to ibuprofen for joint pain. ( Griffiths, P; Ruane, R, 2002)
"To investigate short-term efficacy and safety of a novel lipid ibuprofen formulation 1200 mg/day compared with standard ibuprofen 1200 mg/day and 2400 mg/day in episodic knee arthralgia/flaring pain."5.24A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study. ( Bierma-Zeinstra, SMA; Brew, J; Conaghan, PG; Kilbourn, A; Stoner, K; Wilson, R, 2017)
"To study the effect of Lanconone® (1000 mg) on acute pain on exertion as compared to the standard of care, Ibuprofen (400 mg)."5.22A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain. ( Girandola, RN; Loullis, CC; Srivastava, S, 2016)
"To carry out a randomized clinical trial to compare the effect of palmitoylethanolamide (PEA) versus ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), for pain relief in temporomandibular joint (TMJ) osteoarthritis or arthralgia."5.16Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain. ( Bartolucci, ML; Bonetti, GA; Bortolotti, F; Gatto, MR; Marini, I, 2012)
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains."5.12Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006)
"For investigator and patient assessment of knee joint pain, naproxen sodium (440/660 mg) and ibuprofen were clinically effective at relieving pain compared with placebo (n = 444); both treatments reduced the mean symptom score by 30-45%, compared with a 20-25% reduction with placebo."5.11Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and Ibuprofen in the treatment of osteoarthritis of the knee. ( Minic, M; Schiff, M, 2004)
"To determine the effectiveness of oral glucosamine with ibuprofen for the relief of joint pain in osteoarthritis a mini-review (Griffiths, 2002) of double-blind randomized controlled trials comparing the two was undertaken."4.81Glucosamine therapy compared to ibuprofen for joint pain. ( Griffiths, P; Ruane, R, 2002)
"Conjunction of fever, generalised urticaria, joint/bone pain and monoclonal gammopathy of kappa type having established the diagnosis of Schnitzler's syndrome, treatment with ibuprofen was started (initially 1,200 mg daily by mouth, followed by reduction to 600 mg daily)."4.79[The Schnitzler syndrome as a cause of recurrent fever of unknown origin]. ( Maier, R; Nagel, HG; Reuther, G; Winckelmann, G, 1996)
" Gastrointestinal adverse drug reactions were reported in 8 patients (3."2.79Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee. ( Böttcher, E; Eller, N; Hawel, R; Mitterhuber, J; Rieger, JD; Stallinger, S; Zamani, O, 2014)
" No adverse event was recorded."2.71Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study. ( Fischer, M; Schreyger, F; Trnavský, K; Vögtle-Junkert, U, 2004)
"Ibuprofen has been found to result in approximately 50-60% improvement over placebo in WOMAC scores, including those reflecting inflammatory joint pain in knee and hip OA or other indices of pain, disability and impaired function."2.48Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials. ( Adatia, A; Kean, WF; Rainsford, KD, 2012)
"Treatment with ibuprofen and splinting resulted in complete symptom resolution."1.39Acute calcific tendinitis of the wrist. ( Bral, D; Geiderman, JM; Torbati, SS, 2013)
"We report a case of systemic onset juvenile idiopathic arthritis (SOJIA), the manifestations of which started with fever and skin rash followed by arthritis within neonatal age."1.35Systemic onset juvenile idiopathic arthritis--its unusual presentation. ( Chattopadhyay, N; Ghosh, JB; Gupta, D, 2008)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (12.00)18.2507
2000's7 (28.00)29.6817
2010's12 (48.00)24.3611
2020's3 (12.00)2.80

Authors

AuthorsStudies
Thomas, MJ1
Yu, D1
Nicholls, E1
Bierma-Zeinstra, S1
Conaghan, PG2
Stoner, KJ1
Neogi, T1
Parry, EL1
Peat, G1
Jethwa, T1
Abadin, A1
Pujalte, G1
Gomes, TPO1
Souza, JIN1
Somerlate, LC1
Mendonça, VA1
Lima, NM1
Carli, GP1
Castro, SBR1
de Jesus A S Andrade, T1
Dias, JVL1
Oliveira, MAL1
Alves, CCS1
Carli, AP1
Hoag, SD1
Chung, K1
Bierma-Zeinstra, SMA1
Brew, J1
Stoner, K1
Wilson, R1
Kilbourn, A1
Petersen, KK1
Simonsen, O1
Olesen, AE1
Mørch, CD1
Arendt-Nielsen, L1
Kumar, KJ1
Manjunath, VG1
Shailashree, M1
Girish, GN1
Zamani, O1
Böttcher, E1
Rieger, JD1
Mitterhuber, J1
Hawel, R1
Stallinger, S1
Eller, N1
Dimitroulis, G1
Girandola, RN1
Srivastava, S1
Loullis, CC1
Castelnuovo, E1
Cross, P1
Mt-Isa, S1
Spencer, A1
Underwood, M1
Ghosh, JB1
Gupta, D1
Chattopadhyay, N1
Dixson, M1
Wark, JD1
Bensen, W1
Recknor, C1
Ryabitseva, O1
Chiodo, J1
Mesenbrink, P1
de Villiers, TJ1
Adatia, A1
Rainsford, KD1
Kean, WF1
Marini, I1
Bartolucci, ML1
Bortolotti, F1
Gatto, MR1
Bonetti, GA1
Torbati, SS1
Bral, D1
Geiderman, JM1
Trnavský, K1
Fischer, M1
Vögtle-Junkert, U1
Schreyger, F1
Schiff, M1
Minic, M1
Dalton, JD1
Schweinle, JE1
Ambrocio, DU1
John, D1
Winckelmann, G1
Nagel, HG1
Maier, R1
Reuther, G1
Box, SA1
Lee, MR1
Schifter, T1
Lewinski, UH1
Ruane, R1
Griffiths, P1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu[NCT06105840]Phase 1/Phase 270 participants (Anticipated)Interventional2023-08-27Enrolling by invitation
A Double Blind Randomized Comparator Controlled Study to Assess the Effect of E-OA-07 (Lanconone) on Acute Pain Response in Subjects Suffering From Osteoarthritis of the Knee[NCT02417506]72 participants (Actual)Interventional2014-08-31Completed
To Assess the Lanconone® (E-OA-07) Efficacy in Physical Activity-related Pain- LEAP Study[NCT03262805]73 participants (Actual)Interventional2017-08-28Completed
Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721]Phase 2/Phase 350 participants (Actual)Interventional2015-07-31Completed
A Randomized, Double-Blind, Parallel-Group Study Comparing the Safety and Effectiveness of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Ankle Sprains.[NCT00261560]Phase 4260 participants (Actual)InterventionalCompleted
Arthroscopic Surgery Versus Non-surgical Treatment of Osteoarthritis of the Knee[NCT00158431]Phase 3186 participants (Actual)Interventional1999-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for ibuprofen and Joint Pain

ArticleYear
Osteoarthritis of the knee and hip. Part II: therapy with ibuprofen and a review of clinical trials.
    The Journal of pharmacy and pharmacology, 2012, Volume: 64, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Hip; Hip Joint; Humans; Ibuprofen; Knee; Knee J

2012
[The Schnitzler syndrome as a cause of recurrent fever of unknown origin].
    Deutsche medizinische Wochenschrift (1946), 1996, Jul-05, Volume: 121, Issue:27

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Chronic Disease; Female; Fever of Unknown Origi

1996
Glucosamine therapy compared to ibuprofen for joint pain.
    British journal of community nursing, 2002, Volume: 7, Issue:3

    Topics: Arthralgia; Glucosamine; Humans; Ibuprofen; Osteoarthritis; Treatment Outcome

2002

Trials

11 trials available for ibuprofen and Joint Pain

ArticleYear
Short-Term Recovery Trajectories of Acute Flares in Knee Pain: A UK-Netherlands Multicenter Prospective Cohort Analysis.
    Arthritis care & research, 2020, Volume: 72, Issue:12

    Topics: Acute Pain; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Disease Progression; D

2020
Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study.
    Inflammopharmacology, 2021, Volume: 29, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Curcuma; Female

2021
A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study.
    Osteoarthritis and cartilage, 2017, Volume: 25, Issue:12

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsules; Double-Blind

2017
Comparison of safety, efficacy and tolerability of dexibuprofen and ibuprofen in the treatment of osteoarthritis of the hip or knee.
    Wiener klinische Wochenschrift, 2014, Volume: 126, Issue:11-12

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Ster

2014
A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
    Trials, 2016, Apr-06, Volume: 17

    Topics: Acute Pain; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Met

2016
A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
    Trials, 2016, Apr-06, Volume: 17

    Topics: Acute Pain; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Met

2016
A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
    Trials, 2016, Apr-06, Volume: 17

    Topics: Acute Pain; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Met

2016
A clinical trial comparing Lanconone® with ibuprofen for rapid relief in acute joint pain.
    Trials, 2016, Apr-06, Volume: 17

    Topics: Acute Pain; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Met

2016
Cost-effectiveness of advising the use of topical or oral ibuprofen for knee pain; the TOIB study [ISRCTN: 79353052].
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:7

    Topics: Administration, Oral; Administration, Topical; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Age

2008
Treatment with acetaminophen/paracetamol or ibuprofen alleviates post-dose symptoms related to intravenous infusion with zoledronic acid 5 mg.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2012, Volume: 23, Issue:2

    Topics: Acetaminophen; Aged; Arthralgia; Body Temperature; Bone Density Conservation Agents; Diphosphonates;

2012
Palmitoylethanolamide versus a nonsteroidal anti-inflammatory drug in the treatment of temporomandibular joint inflammatory pain.
    Journal of orofacial pain, 2012,Spring, Volume: 26, Issue:2

    Topics: Adult; Amides; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Method; Endocannabi

2012
Efficacy and safety of 5% ibuprofen cream treatment in knee osteoarthritis. Results of a randomized, double-blind, placebo-controlled study.
    The Journal of rheumatology, 2004, Volume: 31, Issue:3

    Topics: Administration, Topical; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Bl

2004
Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and Ibuprofen in the treatment of osteoarthritis of the knee.
    The Journal of rheumatology, 2004, Volume: 31, Issue:7

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Double-Blind Method; Female; Humans; Ibup

2004
Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains.
    Annals of emergency medicine, 2006, Volume: 48, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Injuries; Arthralgia; Contusions; Double-Blind Method

2006

Other Studies

11 other studies available for ibuprofen and Joint Pain

ArticleYear
Rare case of symptomatic calcific tendinopathy of the origin of rectus femoris tendon.
    BMJ case reports, 2020, Dec-13, Volume: 13, Issue:12

    Topics: Arthralgia; Calcinosis; Diagnosis, Differential; Exercise Therapy; Female; Hip Joint; Humans; Ibupro

2020
Severe polyarthralgia, high-grade fever, diffuse maculopapular rash on trunk and extremities · Dx?
    The Journal of family practice, 2017, Volume: 66, Issue:4

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Ankle; Anti-Inflammatory Agents; Arthralgia; Caribbe

2017
Pain inhibitory mechanisms and response to weak analgesics in patients with knee osteoarthritis.
    European journal of pain (London, England), 2019, Volume: 23, Issue:10

    Topics: Acetaminophen; Aged; Analgesia; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; A

2019
Coinfection with dengue and chikungunya--a case report.
    Journal of the Indian Medical Association, 2012, Volume: 110, Issue:10

    Topics: Alphavirus Infections; Analgesics, Non-Narcotic; Arthralgia; Chikungunya Fever; Child; Coinfection;

2012
Outcomes of temporomandibular joint arthroscopy in patients with painful but otherwise normal joints.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2015, Volume: 43, Issue:6

    Topics: Adult; Aged; Analgesics; Arthralgia; Arthroscopy; Cohort Studies; Female; Follow-Up Studies; Humans;

2015
Systemic onset juvenile idiopathic arthritis--its unusual presentation.
    Indian journal of pediatrics, 2008, Volume: 75, Issue:4

    Topics: Arthralgia; Arthritis, Juvenile; Diagnosis, Differential; Drug Therapy, Combination; Exanthema; Feve

2008
Pediatric rash and joint pain: a case review.
    Journal of emergency nursing, 2010, Volume: 36, Issue:6

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Joint; Anti-Bacterial Agents; Arthralgia; Ceftriaxone

2010
Acute calcific tendinitis of the wrist.
    The Journal of emergency medicine, 2013, Volume: 44, Issue:2

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Calcinosis; Chills; Edema

2013
57-year-old Asian-American man with Kikuchi's disease.
    Hawaii medical journal, 2006, Volume: 65, Issue:11

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Asian; Biopsy; Diagno

2006
A systemic reaction following exposure to a pyrethroid insecticide.
    Human & experimental toxicology, 1996, Volume: 15, Issue:5

    Topics: Abdominal Pain; Agricultural Workers' Diseases; Analgesics, Opioid; Animals; Anti-Allergic Agents; A

1996
Adult onset Still's disease associated with Epstein-Barr virus infection in a 66-year-old woman.
    Scandinavian journal of rheumatology, 1998, Volume: 27, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Antirheumatic Agents; Arthralgia;

1998