Page last updated: 2024-10-28

ibuprofen and Intestinal Perforation

ibuprofen has been researched along with Intestinal Perforation in 10 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Intestinal Perforation: Opening or penetration through the wall of the INTESTINES.

Research Excerpts

ExcerptRelevanceReference
"To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment."7.72Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants. ( Demir, K; Duman, N; Gurcu, O; Kumral, A; Ozkan, H; Tatli, MM, 2004)
"Gastrointestinal complications observed in infants treated with ibuprofen for PDA including gastrointestinal perforations occur in less mature infants."3.96Adverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates. ( Berthiller, J; Bouamari, H; Claris, O; Ndour, D; Nguyen, KA; Plaisant, F, 2020)
"To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA."3.79Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013)
"To discuss intestinal side effects of ibuprofen in the treatment of patent ductus arteriosus, after having observed two cases of spontaneous intestinal perforation following ibuprofen treatment."3.72Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants. ( Demir, K; Duman, N; Gurcu, O; Kumral, A; Ozkan, H; Tatli, MM, 2004)
" Use of low risk drugs in low dosage as first line treatment would substantially reduce the morbidity and mortality due to serious gastrointestinal toxicity from these drugs."2.39Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. ( Carson, JL; Fries, JT; Garcia Rodriguez, LA; Griffin, M; Hawkey, C; Henry, D; Hill, S; Lim, LL; Logan, R; Moride, Y; Perez Gutthann, S; Savage, R, 1996)
"Management of persistently patent ductus arteriosus (PDA) in extremely low-birth-weight infants (ELBWIs) requires attention due to the risk of tissue hypoperfusion."1.91Association between gastrointestinal perforation and patent ductus arteriosus in extremely-low-birth-weight infants: a retrospective study of our decade-long experience. ( Ibara, S; Ieiri, S; Ikee, T; Ikoma, S; Kawano, M; Kawano, T; Machigashira, S; Masuya, R; Matsukubo, M; Murakami, M; Muto, M; Nakame, K; Noguchi, H; Sugita, K; Torikai, M, 2023)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's2 (20.00)29.6817
2010's4 (40.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Muto, M1
Sugita, K1
Murakami, M1
Ikoma, S1
Kawano, M1
Masuya, R1
Matsukubo, M1
Kawano, T1
Machigashira, S1
Nakame, K1
Torikai, M1
Ikee, T1
Noguchi, H1
Ibara, S1
Ieiri, S1
Tuteja, A1
Pournami, F1
Kolisambeevi, AA1
Nandakumar, A1
Prabhakar, J1
Jain, N1
Ndour, D1
Bouamari, H1
Berthiller, J1
Claris, O1
Plaisant, F1
Nguyen, KA1
Yehiyan, A1
Barman, S1
Varia, H1
Pettit, S1
Chan, NM1
Law, CW1
Kwan, KF1
Rao, R1
Bryowsky, K1
Mao, J1
Bunton, D1
McPherson, C1
Mathur, A1
Sivanandan, S1
Bali, V1
Soraisham, AS1
Harabor, A1
Kamaluddeen, M1
Tatli, MM1
Kumral, A1
Duman, N1
Demir, K1
Gurcu, O1
Ozkan, H1
Clarke, SF1
Arepalli, N1
Armstrong, C1
Dargan, PI1
Henry, D1
Lim, LL1
Garcia Rodriguez, LA1
Perez Gutthann, S1
Carson, JL1
Griffin, M1
Savage, R1
Logan, R1
Moride, Y1
Hawkey, C1
Hill, S1
Fries, JT1

Reviews

1 review available for ibuprofen and Intestinal Perforation

ArticleYear
Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis.
    BMJ (Clinical research ed.), 1996, Jun-22, Volume: 312, Issue:7046

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cohort Studies; Dose-Response Relatio

1996

Other Studies

9 other studies available for ibuprofen and Intestinal Perforation

ArticleYear
Association between gastrointestinal perforation and patent ductus arteriosus in extremely-low-birth-weight infants: a retrospective study of our decade-long experience.
    Pediatric surgery international, 2023, Feb-15, Volume: 39, Issue:1

    Topics: Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Humans; Ibuprofen; Indomethacin; Infant, Extr

2023
Paracetamol for Patent Ductus Arteriosus Closure: High Osmolality of Enteral Form and Spontaneous Intestinal Perforation.
    Indian journal of pediatrics, 2020, Volume: 87, Issue:9

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Ibuprofen; Intestinal Pe

2020
Adverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:8

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; In

2020
Short-course high-dose ibuprofen causing both early and delayed jejunal perforations in a non-smoking man.
    BMJ case reports, 2017, Dec-22, Volume: 2017

    Topics: Abdominal Pain; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Humans; Ibuprofen; Intestinal Pe

2017
Ibuprofen versus indomethacin treatment of patent ductus arteriosus: comparative effectiveness and complications.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2014, Volume: 20, Issue:3

    Topics: Bronchopulmonary Dysplasia; Creatinine; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indome

2014
Gastrointestinal complications associated with ibuprofen therapy for patent ductus arteriosus.
    Journal of perinatology : official journal of the California Perinatal Association, 2011, Volume: 31, Issue:7

    Topics: Cohort Studies; Confidence Intervals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; D

2011
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
    American journal of perinatology, 2013, Volume: 30, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema

2013
Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants.
    Acta paediatrica (Oslo, Norway : 1992), 2004, Volume: 93, Issue:7

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Hu

2004
Duodenal perforation after ibuprofen overdose.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:7

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Duodenal Diseases; Duodenal Ulce

2004