ibuprofen has been researched along with Inflammation in 227 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia." | 9.69 | Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 9.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "The primary purpose of this study was to measure the influence of ibuprofen use during the 160-km Western States Endurance Run on endotoxemia, inflammation, and plasma cytokines." | 9.12 | Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. ( Davis, JM; Dumke, CL; Henson, DA; Lind, RH; McAnulty, LS; McAnulty, SR; Morrow, JD; Murphy, EA; Nieman, DC; Oley, K; Utter, AC, 2006) |
| "Elevated levels of homocysteine (Hcy) in the blood, called hyperhomocysteinemia (HHcy), is a prevalent risk factor for it has been shown that Hcy induces oxidative stress and increases microglial activation and neuroinflammation, as well as causes cognitive impairment, which have been linked to the neurodegenerative process." | 8.12 | Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation? ( Coutinho-Silva, R; Dos Santos, TM; Leite-Aguiar, R; Ramires Junior, OV; Savio, LEB; Silveira, JS; Wyse, ATS, 2022) |
| "The conventional dosage forms (tablets, capsules) of ibuprofen have less potential in the suppression of pain and inflammation due to their slow dissolution rates and lower bioavailability." | 8.02 | Ibuprofen-loaded centrifugally spun microfibers for quick relief of inflammation in rats. ( Abbas, N; Ali, E; Arshad, MS; Hussain, A; Hussain, F; Mahmood, F; Mudassir, J; Nasir, S, 2021) |
| "The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors." | 8.02 | The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 7.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "These results demonstrate that TNF-alpha upregulated malignant melanoma migration in vitro and that this could be reduced by ibuprofen both in solution and delivered from a hydrogel." | 7.75 | Ibuprofen and hydrogel-released ibuprofen in the reduction of inflammation-induced migration in melanoma cells. ( Dibden, C; Lalla, R; Macneil, S; Marques, CM; Redpath, M; Waddon, A, 2009) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 7.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| " The present study was undertaken to assess markers of inflammation, arthritis and pain in rats with adjuvant arthritis undergoing treatment with ibuprofen cream (Dolgit cream) and placebo." | 7.72 | Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo. ( Istok, R; Rovenský, J; Stancíková, M; Svík, K, 2003) |
| " The current study used an in vitro spinal superfusion model to investigate the effect of substance P (SP), N-methyl-d-aspartate (NMDA), and capsaicin on multiple prostanoid release from dorsal spinal cord of naive rats as well as rats that underwent peripheral injury and inflammation (knee joint kaolin/carrageenan)." | 7.70 | In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. ( Dirig, DM; Yaksh, TL, 1999) |
| "We have used the rat air pouch model of inflammation and S(+)ibuprofen as an experimental model system to enable the quantitative assessment of the pharmacokinetic determinants of site specific drug delivery." | 7.69 | Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation. ( Brennan, BS; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1994) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 7.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "To assess the ability of ibuprofen to influence the extent of platelet aggregation and leukocyte infiltration during acute myocardial infarction, autologous indium-111 (111-In)-labeled platelets or leukocytes were injected before 60 minutes of left circumflex coronary artery (LCx) occlusion, followed by 24 hours of reperfusion in the canine heart." | 7.66 | The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction. ( Hook, BG; Lucchesi, BR; Rigot, VH; Romson, JL; Schork, MA; Swanson, DP, 1982) |
| "Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment." | 6.73 | Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. ( Dionne, RA; Hamza, M; Ramsay, ES; Wahl, SM; Wang, XM; Wu, TX, 2007) |
| "The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years." | 6.61 | Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview. ( Barbagallo, M; Sacerdote, P, 2019) |
| "During bacterial infection, reactive oxygen species (ROS) and other signaling pathways are activated, which intensify inflammation and increase ALI-related mortality and morbidity." | 5.91 | Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury. ( Cao, H; Chen, W; Feng, B; Gao, C; Muhammad, W; Wang, R; Wang, S; Xie, J; Xu, Y; Yao, Q; Yu, Y; Zhang, Y; Zhou, J; Zhu, J, 2023) |
| "The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia." | 5.69 | Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023) |
| " Moreover, night administration of ibuprofen might not provide any significant benefits in terms of pain management and control of inflammation, and two doses during the day only could be sufficient for pain management after surgical interventions." | 5.51 | NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial. ( Abusamak, M; Al Habashneh, R; Al-Nusair, M; Al-Tamimi, M; Al-Waeli, H; Gao, Q; Ghanim, M; Nicolau, B; Tamimi, F; Tamimi, Z, 2022) |
| "The hepatic encephalopathy was induced by bile-duct ligation (BDL), and the animals received first dose of MINO and/or IBU 15 days later and then every day until the 28 day." | 5.51 | Inhibition of inflammation is not enough for recovery of cognitive impairment in hepatic encephalopathy: Effects of minocycline and ibuprofen. ( Firouzjaei, MA; Haghani, M; Mohammadi, F; Mohammadian, F; Shabani, M; Shid Moosavi, SM, 2019) |
| " Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings." | 5.43 | Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016) |
| "Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease." | 5.42 | Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015) |
| "A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant BRAF and both events proved to cooperate in tumor cell survival." | 5.39 | Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. ( Chastre, E; Goncalves, V; Henriques, A; Henriques, AF; Jordan, P; Kotelevets, L; Matos, P; Moyer, MP; Zerbib, P, 2013) |
| "Patients with hepatic encephalopathy show altered motor function, psychomotor slowing, and hypokinesia, which are reproduced in rats with portacaval shunts (PCS)." | 5.35 | Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. ( Cauli, O; Felipo, V; Llansola, M; Mansouri, MT; Piedrafita, B; Rodrigo, R, 2009) |
| "The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits." | 5.31 | Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000) |
| " Of those, 14 displayed a slightly increased systemic inflammation (CRP>2mg/l) and were randomly assigned to NSAID (Ibuprofen 1800mg/day) or placebo treatment for 1week." | 5.22 | No effect of anti-inflammatory medication on postprandial and postexercise muscle protein synthesis in elderly men with slightly elevated systemic inflammation. ( Bechshoeft, R; Dideriksen, K; Holm, L; Malmgaard-Clausen, NM; Mikkelsen, UR; Petersen, RK; Reitelseder, S, 2016) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 5.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "The primary purpose of this study was to measure the influence of ibuprofen use during the 160-km Western States Endurance Run on endotoxemia, inflammation, and plasma cytokines." | 5.12 | Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. ( Davis, JM; Dumke, CL; Henson, DA; Lind, RH; McAnulty, LS; McAnulty, SR; Morrow, JD; Murphy, EA; Nieman, DC; Oley, K; Utter, AC, 2006) |
| "To evaluate the effects of endotoxemia on respiratory controller function, 12 subjects were randomized to receive endotoxin or saline; six also received ibuprofen, a cyclooxygenase inhibitor, and six received placebo." | 5.09 | Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. ( Banks, SM; Godin, PJ; Jubran, A; Preas, HL; Reda, D; Suffredini, AF; Tobin, MJ; Vandivier, RW, 2001) |
| "Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months." | 4.95 | Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. ( Boner, A; Chiarugi, A; de Martino, M; De' Angelis, GL; Montini, G, 2017) |
| "There is epidemiological observation that long-term treatment of patients suffering from rheumatoid arthritis with ibuprofen results in reduced risk and delayed onset of Alzheimer's disease (AD)." | 4.82 | Ibuprofen and Alzheimer's disease. ( Dokmeci, D, 2004) |
| "The development of radiolabeled ibuprofen as an imaging agent for inflammation and infection may have significant clinical implications for the diagnosis and management of various inflammatory and infectious diseases." | 4.31 | ( Durkan, K; Ichedef, C; Koksal Karayildirim, C; Yurt Kilcar, A, 2023) |
| "Elevated levels of homocysteine (Hcy) in the blood, called hyperhomocysteinemia (HHcy), is a prevalent risk factor for it has been shown that Hcy induces oxidative stress and increases microglial activation and neuroinflammation, as well as causes cognitive impairment, which have been linked to the neurodegenerative process." | 4.12 | Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation? ( Coutinho-Silva, R; Dos Santos, TM; Leite-Aguiar, R; Ramires Junior, OV; Savio, LEB; Silveira, JS; Wyse, ATS, 2022) |
| "The conventional dosage forms (tablets, capsules) of ibuprofen have less potential in the suppression of pain and inflammation due to their slow dissolution rates and lower bioavailability." | 4.02 | Ibuprofen-loaded centrifugally spun microfibers for quick relief of inflammation in rats. ( Abbas, N; Ali, E; Arshad, MS; Hussain, A; Hussain, F; Mahmood, F; Mudassir, J; Nasir, S, 2021) |
| "The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors." | 4.02 | The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021) |
| "The NSAIDs ibuprofen and diclofenac were administered to C57BL/6 mice after induction of pancreatitis with serial injections of cerulein." | 3.88 | Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation. ( Bombardo, M; Chen, R; Graf, R; Malagola, E; Rudnicka, A; Sonda, S, 2018) |
| "The present study is to investigate the neuroprotective effect of ibuprofen by intranasal administration of mucoadhesive microemulsion (MMEI) against inflammation-mediated by dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease (PD)." | 3.83 | Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model. ( Chuttani, K; Mandal, S; Mandal, SD; Sawant, KK; Subudhi, BB, 2016) |
| "In the therapy of rheumatoid arthritis, ibuprofen (IBU) is widely used; however, it has been limited the clinical use by its systemic side effect, such as gastrointestinal lesions." | 3.83 | Pharmacokinetic Studies of Gel System Containing Ibuprofen Solid Nanoparticles. ( Ito, Y; Nagai, N; Tanino, T, 2016) |
| " Further, 11-14 demonstrated comparable anti-inflammatory activity with ibuprofen in carrageenan-induced rat paw edema assay and appreciable inhibition of lipopolysaccharide (LPS) induced pro-inflammatory mediators (TNF-α and IL-1β) in Sprague Dawley (SD) rats." | 3.81 | 2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies. ( Bairwa, K; Bhutani, KK; Gangwal, R; Jachak, SM; Jaiswal, G; Patel, NK; Sangamwar, AT, 2015) |
| "This study assessed the effect of the combination of anethole and ibuprofen in comparison with monotherapy by either drug alone, using two in vivo inflammatory models, namely the pleurisy and paw edema in rats." | 3.81 | Synergistic effects of anethole and ibuprofen in acute inflammatory response. ( Bersani-Amado, CA; Cuman, RK; Rocha, BA; Velazquez-Martinez, CA; Wiirzler, LA; Wisniewski-Rebecca, ES, 2015) |
| " To investigate whether innate rodent burrowing is a useful alternative behavioural readout for assessment of analgesic efficacy, a complete Freund's adjuvant (CFA)-induced model of sub-chronic inflammation was used to compare the effects of naproxen, ibuprofen and pregabalin in weight-bearing (WB), open-field (OF) and burrowing assays." | 3.80 | Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation. ( Christoph, T; Leipelt, A; Pasqualon, T; Read, SJ; Robens, A; Rutten, K; Schiene, K, 2014) |
| " These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain." | 3.80 | Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014) |
| "9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy." | 3.80 | S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014) |
| " Systemic administration of 1 reduced acetic acid-induced writhing, the inflammatory phase of formalin-induced pain, and capsaicin-induced mechanical allodynia." | 3.79 | Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea. ( Baeyens, JM; Cobos, EJ; Entrena, JM; García-Granados, A; Nieto, FR; Parra, A, 2013) |
| " This study characterized the manner in which levetiracetam interacts with analgesics (ibuprofen, celecoxib, and paracetamol) and caffeine to suppress hyperalgesia in a model of localized inflammation." | 3.79 | Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats. ( Micov, AM; Stepanović-Petrović, RM; Tomić, MA, 2013) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 3.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| " As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA." | 3.78 | Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. ( Del Rio, R; Iturriaga, R; Madrid, C; Moya, EA; Parga, MJ, 2012) |
| " To examine the role of inflammation, results from 6-week HRHF rats were compared to rats receiving ibuprofen or anti-TNF-α treatment in HRHF weeks 4-6." | 3.78 | Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation. ( Abdelmagid, SM; Amin, M; Barbe, MF; Barr, AE; Litvin, J; Popoff, SN; Rico, M; Safadi, FF, 2012) |
| " The defects in adult neurogenesis are prevented by long-term treatment with the non-steroidal anti-inflammatory agents ibuprofen or naproxen suggesting that neuroinflammation is critically involved in impaired adult neurogenesis in AICD transgenic mice." | 3.76 | APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation. ( Ghosal, K; Pimplikar, SW; Stathopoulos, A, 2010) |
| "Recently we reported that intrathalamic microinjection of carbachol triggers generalized convulsive seizures (GCS) followed by severe inflammatory response including edema, microhemorrhages, and subsequent degeneration of amygdaloallocortical area." | 3.76 | Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways. ( Mraovitch, S; Régnier, A; Vicaut, E, 2010) |
| "These results demonstrate that TNF-alpha upregulated malignant melanoma migration in vitro and that this could be reduced by ibuprofen both in solution and delivered from a hydrogel." | 3.75 | Ibuprofen and hydrogel-released ibuprofen in the reduction of inflammation-induced migration in melanoma cells. ( Dibden, C; Lalla, R; Macneil, S; Marques, CM; Redpath, M; Waddon, A, 2009) |
| "Substituted thiazoles with different structural features were synthesized and screened for their anti-inflammatory activity in acute carrageenin induced rat paw edema model and chronic formalin induced rat paw edema model." | 3.74 | 2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. ( Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S, 2008) |
| " Its major active components, harpagoside (1), harpagide (2), 8-coumaroylharpagide (3), and verbascoside (4), are believed to interact either synergistically or antagonistically in modulating the enzymes responsible for inducing inflammation, although this has not been probed hitherto." | 3.74 | Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro. ( Abdelouahab, N; Heard, C, 2008) |
| ", synergistic) in preclinical models of visceral and inflammatory pain, specifically acetic acid-induced writhing in mice and carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats." | 3.74 | Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2007) |
| "Duloxetine, a selective but balanced serotonergic and noradrenergic reuptake inhibitor, was evaluated in the acute nociceptive pain models of tail flick and hot plate in mice and in the persistent and/or inflammatory pain models of acetic acid-induced writhing in mice, carrageenan-induced thermal hyperalgesia and mechanical allodynia in rats, and capsaicin-induced mechanical allodynia in rats." | 3.73 | Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents. ( Jones, CK; Peters, SC; Shannon, HE, 2005) |
| " The present study was undertaken to assess markers of inflammation, arthritis and pain in rats with adjuvant arthritis undergoing treatment with ibuprofen cream (Dolgit cream) and placebo." | 3.72 | Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo. ( Istok, R; Rovenský, J; Stancíková, M; Svík, K, 2003) |
| "The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia." | 3.71 | Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats. ( Daphtary, KM; Glibetic, M; Heidemann, SM, 2001) |
| " The current study used an in vitro spinal superfusion model to investigate the effect of substance P (SP), N-methyl-d-aspartate (NMDA), and capsaicin on multiple prostanoid release from dorsal spinal cord of naive rats as well as rats that underwent peripheral injury and inflammation (knee joint kaolin/carrageenan)." | 3.70 | In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin. ( Dirig, DM; Yaksh, TL, 1999) |
| "The inhibition of prostaglandin E2 (PGE2) synthesis by S-(+)-ibuprofen and piroxicam have been assessed following intravenous and regional (intrapouch) drug delivery using the rat air-pouch model of inflammation." | 3.69 | Pharmacodynamic comparison of regional drug delivery for non-steroidal anti-inflammatory drugs, using the rat air-pouch model of inflammation. ( Brennan, BS; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1995) |
| "We have used the rat air pouch model of inflammation and S(+)ibuprofen as an experimental model system to enable the quantitative assessment of the pharmacokinetic determinants of site specific drug delivery." | 3.69 | Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation. ( Brennan, BS; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1994) |
| "To determine the permeability characteristics of the rat air pouch model of inflammation using permeability extremes within which the NSAIDs S[+] ibuprofen, piroxicam and diclofenac could be evaluated." | 3.69 | Regional drug delivery I: permeability characteristics of the rat 6-day-old air pouch model of inflammation. ( Brennan, BS; Gifford, LA; Houston, JB; Martin, SW; Reis, ML; Rowland, M; Stevens, AJ, 1995) |
| " These models of acute and chronic inflammation, and the antimitotic model permitted us to evaluate the anti-inflammatory and antimitotic effects of sulindac, ibuprofen, naproxen and glucametacin." | 3.69 | Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. ( Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM, 1996) |
| "The antiphlogistic Ibuprofen incorporated in liposomes caused a decrease of the inflammatory edema induced by Carrageenan in the distal part of the rat's hind leg after both the intramuscular and percutaneous administration." | 3.69 | The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation. ( Bartácková, M; Blazek, K; Hulínská, D; Otová, B; Schramlová, J, 1997) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 3.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| " We investigated, in an animal model, whether a non-steroidal anti-inflammatory drug, ibuprofen, reduced lung inflammation produced by P." | 3.67 | Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa. ( Bellanti, JA; Cerquetti, MC; el-Tawil, G; Hooke, AM; Ramwell, PW; Sordelli, DO, 1985) |
| "To assess the ability of ibuprofen to influence the extent of platelet aggregation and leukocyte infiltration during acute myocardial infarction, autologous indium-111 (111-In)-labeled platelets or leukocytes were injected before 60 minutes of left circumflex coronary artery (LCx) occlusion, followed by 24 hours of reperfusion in the canine heart." | 3.66 | The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction. ( Hook, BG; Lucchesi, BR; Rigot, VH; Romson, JL; Schork, MA; Swanson, DP, 1982) |
| " Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents." | 3.66 | [Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981) |
| "Ibuprofen treatment significantly attenuated the variation (Δ) in CRE following first immunization in these infants but the current study could not demonstrate an impact on CRP and PgE2 levels." | 2.84 | Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants < 32 Weeks Gestational Age: A Randomized Controlled Study. ( Ben Jmaa, W; Cloutier, A; Germain, N; Hernández, AI; Lachance, C; Lebel, MH; Martin, B; Nuyt, AM; Pladys, P; Sutherland, MR, 2017) |
| "Both rofecoxib and ibuprofen treatment increased the gene expression of the pro-inflammatory mediators, IL6 and CCL2 (chemokine C-C motif ligand 2), following tissue injury compared to the placebo treatment." | 2.73 | Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. ( Dionne, RA; Hamza, M; Ramsay, ES; Wahl, SM; Wang, XM; Wu, TX, 2007) |
| "While inflammation is very significant in the abolition of pathogens and other causes of soreness, a protracted inflammatory procedure takes to outcomes in chronic disease that might finally affect in organ failure or damage." | 2.72 | Contemporary advances of cyclic molecules proposed for inflammation. ( Neha, K; Wakode, S, 2021) |
| "Pretreatment with ibuprofen, a nonspecific COX inhibitor, attenuated the febrile and systemic response to LPS and inhibited prostanoid biosynthesis." | 2.69 | Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. ( Burke, A; FitzGerald, GA; Habib, A; Kapoor, S; Lawson, JA; Mardini, IA; McAdam, BF, 2000) |
| "The pharmacological agents approved for treating pain in these patients are few, also considering the recent limitation for codeine in children younger than 12 years." | 2.61 | Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview. ( Barbagallo, M; Sacerdote, P, 2019) |
| "Post-surgical neuroinflammation is a documented phenomenon that results in synaptic impairment, neuronal dysfunction and death, and impaired neurogenesis." | 2.58 | Surgery, neuroinflammation and cognitive impairment. ( Alam, A; Hana, Z; Jin, Z; Ma, D; Suen, KC, 2018) |
| "Ibuprofen is a racemate." | 2.49 | Ibuprofen: from invention to an OTC therapeutic mainstay. ( Rainsford, KD, 2013) |
| " The evidence for modes of action of ibuprofen are considered in relation to its actions in controlling inflammation, pain and fever, as well as the adverse effects of the drug." | 2.45 | Ibuprofen: pharmacology, efficacy and safety. ( Rainsford, KD, 2009) |
| " Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset." | 2.43 | Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. ( Praticò, D; Townsend, KP, 2005) |
| "Airway inflammation is now recognized as a major factor in the pathogenesis of lung disease in cystic fibrosis." | 2.42 | [Airway inflammation in cystic fibrosis]. ( Derelle, J, 2003) |
| "During bacterial infection, reactive oxygen species (ROS) and other signaling pathways are activated, which intensify inflammation and increase ALI-related mortality and morbidity." | 1.91 | Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury. ( Cao, H; Chen, W; Feng, B; Gao, C; Muhammad, W; Wang, R; Wang, S; Xie, J; Xu, Y; Yao, Q; Yu, Y; Zhang, Y; Zhou, J; Zhu, J, 2023) |
| "The in-vivo pharmacodynamic (PD) studies were performed in mice." | 1.72 | Pharmacodynamic/pharmacokinetic correlation of optimized ibuprofen nanosuspensions having enhanced anti-inflammatory and antinociceptive activity. ( Bandarkar, F; Masocha, W; Nada, A, 2022) |
| " To evaluate THEDES anti-CRC therapeutic potential, their physico-chemical properties, bioavailability and bioactivity, were explored." | 1.72 | Selective terpene based therapeutic deep eutectic systems against colorectal cancer. ( Duarte, ARC; Miguel Castro, M; Oliveira, F; Paiva, A; Pereira, J; Rita Jesus, A; Santos, F, 2022) |
| "The most common treatment of inflammation is non-steroidal anti-inflammatory drugs (NSAIDs)." | 1.72 | Design, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives: In silico and in vitro Study. ( Hamid, SJ; Salih, T, 2022) |
| "Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0." | 1.62 | Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021) |
| " Therefore, the development of an inhalable formulation with high bioavailability in the lungs was the leitmotiv of our investigation." | 1.56 | Ibuprofen, a traditional drug that may impact the course of COVID-19 new effective formulation in nebulizable solution. ( Alasino, RV; Beltramo, DM; García, NH; Muñoz, SE; Porta, DJ, 2020) |
| "The hepatic encephalopathy was induced by bile-duct ligation (BDL), and the animals received first dose of MINO and/or IBU 15 days later and then every day until the 28 day." | 1.51 | Inhibition of inflammation is not enough for recovery of cognitive impairment in hepatic encephalopathy: Effects of minocycline and ibuprofen. ( Firouzjaei, MA; Haghani, M; Mohammadi, F; Mohammadian, F; Shabani, M; Shid Moosavi, SM, 2019) |
| "Sweet's syndrome (SS) or acute febrile neutrophilic dermatosis is an uncommon condition." | 1.48 | Sweet's syndrome: a clinical entity need to discriminate against acute haematogenous periprosthetic joint infection. ( Chung, MJ; Kim, KB; Lee, JH; Lee, JR; Wang, SI, 2018) |
| " The prostate tissue penetration and related pharmacokinetic parameters were evaluated by non-compartmental analysis." | 1.48 | Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue. ( Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK, 2018) |
| "Ibuprofen was given to the treatment group (TG) and water was given to the control group (CG)." | 1.46 | Investigating Cyclooxygenase Inhibition in a Rat Pulmonary Contusion Model: A Laboratory Study Finding No Improvement with Ibuprofen. ( Chatterjee, AR; Croce, MA; Fabian, TC; Huang, J; Khan, NR; Magnotti, LJ; Sharpe, JP, 2017) |
| "We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms." | 1.46 | Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. ( Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ, 2017) |
| " Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings." | 1.43 | Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016) |
| "Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease." | 1.42 | Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015) |
| "The limited bioavailability and rapid clearance of the anti-inflammatory drug Ibuprofen Sodium (IbS) necessitates repeated drug administration." | 1.39 | Poly-(ethylene glycol) modified gelatin nanoparticles for sustained delivery of the anti-inflammatory drug Ibuprofen-Sodium: an in vitro and in vivo analysis. ( H, L; Koyakutty, M; M G, G; Menon, D; Nair, S; Narayanan, D, 2013) |
| "Cystitis was induced in female rats by a single CYP injection." | 1.39 | Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder. ( Augé, C; Chene, G; Coelho, AM; Corman, B; Desoubzdanne, D; Dubourdeau, M; Lluel, P; Palea, S; Vergnolle, N, 2013) |
| "Ibuprofen treatment blocked exercise-induced increases in COX-1 and COX-2-derived prostanoids but also resulted in off-target reductions in leukotriene biosynthesis, and a diminished proresolving lipid mediator response." | 1.39 | Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment. ( Cameron-Smith, D; Lingard, BS; Maddipati, KR; Markworth, JF; Rupasinghe, TW; Sinclair, AJ; Tull, DL; Vella, L, 2013) |
| "The edema was produced in a dose- and time-dependent manner." | 1.39 | Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013) |
| "A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant BRAF and both events proved to cooperate in tumor cell survival." | 1.39 | Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. ( Chastre, E; Goncalves, V; Henriques, A; Henriques, AF; Jordan, P; Kotelevets, L; Matos, P; Moyer, MP; Zerbib, P, 2013) |
| "Ibuprofen arginate is a highly soluble salt formed by combining racemic ibuprofen with the amino acid l-arginine." | 1.38 | Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain. ( Berrocoso, E; Leza, JC; Mico, JA; Ortega-Álvaro, A; Rey-Brea, R, 2012) |
| " An ibuprofen dosage of 1,600 mg/day did not induce LUF syndrome either at continuous periovulatory or discontinuous exposure." | 1.37 | Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies. ( Micu, MC; Micu, R; Ostensen, M, 2011) |
| "Paw volume, thermal hyperalgesia, mechanical allodynia, joint stiffness and mobility behaviors (score) were measured." | 1.37 | Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. ( Bijjem, KR; Kaur, S; Sharma, PL, 2011) |
| "Neuroinflammation was assessed by measuring activation of microglia and inflammatory factors." | 1.36 | Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. ( Agusti, A; Cauli, O; Felipo, V; Garcia-Verdugo, JM; Gomez-Pinedo, U; Hernandez-Rabaza, V; Rodrigo, R, 2010) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Patients with hepatic encephalopathy show altered motor function, psychomotor slowing, and hypokinesia, which are reproduced in rats with portacaval shunts (PCS)." | 1.35 | Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity. ( Cauli, O; Felipo, V; Llansola, M; Mansouri, MT; Piedrafita, B; Rodrigo, R, 2009) |
| "A population-based study of 750 rectal cancer cases with interview and tumor DNA were compared to 1,205 population-based controls." | 1.35 | Tumor markers and rectal cancer: support for an inflammation-related pathway. ( Caan, BJ; Herrick, J; Samowitz, W; Slattery, ML; Wolff, RK, 2009) |
| "Globoid cell leukodystrophy (GLD) or Krabbe disease is a neurodegenerative disorder caused by the deficiency of the lysosomal enzyme galactocerebrosidase (GALC)." | 1.35 | Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy. ( Abraham, RM; Curtis, M; Hooper, DC; Luzi, P; Rafi, MA; Wenger, DA, 2009) |
| "Recently, low grade inflammation has been suspected to be one of the factors responsible for the decreased sensitivity of muscle protein metabolism to food intake." | 1.35 | Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats. ( Averous, J; Bos, C; Combaret, L; Dardevet, D; Magne, H; Peyron, MA; Rieu, I; Savary-Auzeloux, I, 2009) |
| "Inflammation was estimated histologically by quantitative and semiquantitative classification of inflammatory cells on HES and MGG stains and use of videoanalysis after immunohistolabeling with CD-antibodies to a variety of inflammatory cells." | 1.35 | Anti-inflammatory effect of ibuprofen-loaded embolization beads in sheep uterus. ( Laurent, A; Lewis, AL; Namur, J; Pelage, JP; Schwartz-Cornil, I; Taylor, RR; Velzenberger, E; Wassef, M, 2008) |
| "Ibuprofen (IBU) was provided in a rodent chow (375 ppm) for animals 5-19 weeks of age." | 1.33 | Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupus. ( Arsenault, L; Ballok, DA; Denburg, JA; Ma, X; Sakic, B, 2006) |
| "Ibuprofen is a nonsteroidal antiinflammatory drug often prescribed as a racemic formulation." | 1.32 | Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents. ( Bonabello, A; Canaparo, R; Galmozzi, MR; Isaia, GC; Muntoni, E; Serpe, L; Zara, GP, 2003) |
| "(+/-) Ibuprofen sugar derivatives were prepared in order to decrease side-effects and increase bioavailability of (+/-) ibuprofen." | 1.32 | [Synthesis of (+/-) ibuprofen sugar derivatives]. ( Li, YX; Qu, F; Song, N; Sun, X, 2004) |
| "Colitis was induced in rats by an enema containing 2,4,6-trinitrobenzen sulfonic acid." | 1.32 | Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats. ( Ardid, D; Eschalier, A; Etienne, M; Jourdan, D; Millecamps, M, 2004) |
| "The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits." | 1.31 | Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000) |
| "Inflammation was induced in the 6-day-old rat air pouch by injection of carrageenan." | 1.29 | The six-day-old rat air pouch model of inflammation: characterization of the inflammatory response to carrageenan. ( Brennan, BS; Davies, D; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1994) |
| "Treatment with ibuprofen during induced inflammation significantly reduced LEA and increased red blood cell velocity." | 1.29 | Effects of nonsteroidal anti-inflammatory drugs on microvascular dynamics. ( House, SD; Slater, C, 1993) |
| "Ibuprofen was found to decrease neutrophil chemiluminescence, lymphocyte blastogenesis, and helper/inducer T-lymphocyte infiltration of a sponge matrix model." | 1.29 | Effect of ibuprofen on the inflammatory response to surgical wounds. ( Dong, YL; Fleming, RY; Herndon, DN; Waymack, JP; Yan, TZ, 1993) |
| "Pretreatment with allopurinol or ibuprofen reduced both the incidence and the magnitude of translocation at 6 hr in rats and mice (P < 0." | 1.29 | Role of xanthine oxidase and prostaglandins in inflammatory-induced bacterial translocation. ( Deitch, EA; Mainous, MR; Xu, D, 1993) |
| "S(+)Ibuprofen was administered either intravenously or directly into the air pouch at the same time as the irritant (carrageenan)." | 1.28 | Use of the rat air pouch model of inflammation to evaluate regional drug delivery. ( Davies, DE; Houston, JB; Stevens, AJ, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (10.13) | 18.7374 |
| 1990's | 23 (10.13) | 18.2507 |
| 2000's | 52 (22.91) | 29.6817 |
| 2010's | 88 (38.77) | 24.3611 |
| 2020's | 41 (18.06) | 2.80 |
| Authors | Studies |
|---|---|
| Terada, A | 1 |
| Naruto, S | 1 |
| Wachi, K | 1 |
| Tanaka, S | 1 |
| Iizuka, Y | 2 |
| Misaka, E | 1 |
| Franklin, PX | 1 |
| Pillai, AD | 1 |
| Rathod, PD | 1 |
| Yerande, S | 1 |
| Nivsarkar, M | 1 |
| Padh, H | 1 |
| Vasu, KK | 2 |
| Sudarsanam, V | 1 |
| Amir, M | 2 |
| Kumar, H | 2 |
| Javed, SA | 1 |
| Abdelouahab, N | 1 |
| Heard, C | 1 |
| Giri, RS | 1 |
| Thaker, HM | 1 |
| Giordano, T | 1 |
| Williams, J | 1 |
| Rogers, D | 1 |
| Sudersanam, V | 1 |
| Chowdhury, MA | 1 |
| Abdellatif, KR | 1 |
| Dong, Y | 2 |
| Rahman, M | 1 |
| Das, D | 1 |
| Suresh, MR | 1 |
| Knaus, EE | 1 |
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Sujith, KV | 1 |
| Rao, JN | 1 |
| Shetty, P | 1 |
| Kalluraya, B | 1 |
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 2 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Shin, JS | 1 |
| Noh, YS | 1 |
| Yoo, MS | 1 |
| Lee, JY | 1 |
| Cho, YW | 1 |
| Lee, KT | 1 |
| Nieto, FR | 1 |
| Cobos, EJ | 2 |
| Entrena, JM | 2 |
| Parra, A | 1 |
| García-Granados, A | 1 |
| Baeyens, JM | 1 |
| Patel, NK | 1 |
| Bairwa, K | 1 |
| Gangwal, R | 1 |
| Jaiswal, G | 1 |
| Jachak, SM | 1 |
| Sangamwar, AT | 1 |
| Bhutani, KK | 1 |
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Wu, YJ | 1 |
| Guernon, J | 1 |
| McClure, A | 1 |
| Luo, G | 1 |
| Rajamani, R | 1 |
| Ng, A | 1 |
| Easton, A | 1 |
| Newton, A | 1 |
| Bourin, C | 1 |
| Parker, D | 1 |
| Mosure, K | 1 |
| Barnaby, O | 1 |
| Soars, MG | 1 |
| Knox, RJ | 1 |
| Matchett, M | 1 |
| Pieschl, R | 1 |
| Herrington, J | 1 |
| Chen, P | 2 |
| Sivarao, DV | 1 |
| Bristow, LJ | 1 |
| Meanwell, NA | 1 |
| Bronson, J | 1 |
| Olson, R | 1 |
| Thompson, LA | 1 |
| Dzierba, C | 1 |
| Gonzaga, DTG | 1 |
| Ferreira, LBG | 1 |
| Moreira Maramaldo Costa, TE | 1 |
| von Ranke, NL | 1 |
| Anastácio Furtado Pacheco, P | 1 |
| Sposito Simões, AP | 1 |
| Arruda, JC | 1 |
| Dantas, LP | 1 |
| de Freitas, HR | 1 |
| de Melo Reis, RA | 1 |
| Penido, C | 1 |
| Bello, ML | 1 |
| Castro, HC | 1 |
| Rodrigues, CR | 1 |
| Ferreira, VF | 1 |
| Faria, RX | 1 |
| da Silva, FC | 1 |
| Ali, EMH | 1 |
| Abdel-Maksoud, MS | 1 |
| Oh, CH | 1 |
| Hošek, J | 1 |
| Leláková, V | 1 |
| Bobál, P | 1 |
| Pížová, H | 1 |
| Gazdová, M | 1 |
| Malaník, M | 1 |
| Jakubczyk, K | 1 |
| Veselý, O | 1 |
| Landa, P | 1 |
| Temml, V | 1 |
| Schuster, D | 1 |
| Prachyawarakorn, V | 1 |
| Pailee, P | 1 |
| Ren, G | 1 |
| Zpurný, F | 1 |
| Oravec, M | 1 |
| Šmejkal, K | 1 |
| Koppitz, M | 1 |
| Bräuer, N | 1 |
| Ter Laak, A | 1 |
| Irlbacher, H | 1 |
| Rotgeri, A | 1 |
| Coelho, AM | 2 |
| Walter, D | 1 |
| Steinmeyer, A | 1 |
| Zollner, TM | 1 |
| Peters, M | 1 |
| Nagel, J | 1 |
| García-Aranda, MI | 1 |
| Gonzalez-Padilla, JE | 1 |
| Gómez-Castro, CZ | 1 |
| Gómez-Gómez, YM | 1 |
| Rosales-Hernández, MC | 1 |
| García-Báez, EV | 1 |
| Franco-Hernández, MO | 1 |
| Castrejón-Flores, JL | 1 |
| Padilla-Martínez, II | 1 |
| Neha, K | 1 |
| Wakode, S | 2 |
| Kahraman, E | 1 |
| Cevik, B | 1 |
| Tolga Saracoglu, K | 1 |
| Ghosh, S | 1 |
| Bandarkar, F | 1 |
| Masocha, W | 1 |
| Nada, A | 1 |
| Ghanim, AM | 1 |
| Girgis, AS | 1 |
| Kariuki, BM | 1 |
| Samir, N | 1 |
| Said, MF | 1 |
| Abdelnaser, A | 1 |
| Nasr, S | 1 |
| Bekheit, MS | 1 |
| Abdelhameed, MF | 1 |
| Almalki, AJ | 1 |
| Ibrahim, TS | 1 |
| Panda, SS | 1 |
| Tamimi, Z | 1 |
| Abusamak, M | 1 |
| Al-Waeli, H | 1 |
| Al-Tamimi, M | 1 |
| Al Habashneh, R | 1 |
| Ghanim, M | 1 |
| Al-Nusair, M | 1 |
| Gao, Q | 1 |
| Nicolau, B | 1 |
| Tamimi, F | 1 |
| Hussain, A | 1 |
| Hussain, F | 1 |
| Arshad, MS | 1 |
| Abbas, N | 1 |
| Nasir, S | 1 |
| Mudassir, J | 1 |
| Mahmood, F | 1 |
| Ali, E | 1 |
| Kheilnezhad, B | 1 |
| Hadjizadeh, A | 1 |
| Pereira, J | 1 |
| Miguel Castro, M | 1 |
| Santos, F | 1 |
| Rita Jesus, A | 1 |
| Paiva, A | 1 |
| Oliveira, F | 1 |
| Duarte, ARC | 1 |
| Ramires Junior, OV | 1 |
| Dos Santos, TM | 1 |
| Silveira, JS | 1 |
| Leite-Aguiar, R | 1 |
| Coutinho-Silva, R | 1 |
| Savio, LEB | 1 |
| Wyse, ATS | 1 |
| Quek, JY | 1 |
| Bright, R | 1 |
| Dabare, P | 1 |
| Vasilev, K | 1 |
| Hamid, SJ | 1 |
| Salih, T | 1 |
| Quintão, NLM | 1 |
| Reis, JP | 1 |
| Benvenutti, L | 1 |
| Nunes, R | 1 |
| Goldoni, FC | 1 |
| Cozer, MS | 1 |
| de Souza, P | 1 |
| de Cássia Melo Vilhena de Andrade Fonseca da Silva, R | 1 |
| Melato, J | 1 |
| Vaz, CR | 1 |
| Whitaker, JCP | 1 |
| Jesuíno, FW | 1 |
| Costa, MC | 1 |
| Pastor, MVD | 1 |
| Malheiros, A | 1 |
| Meyre-Silva, C | 1 |
| Santin, JR | 1 |
| Rawat, A | 1 |
| Rawat, M | 1 |
| Prakash, OM | 1 |
| Kumar, R | 1 |
| Punetha, H | 1 |
| Rawat, DS | 1 |
| Hodkovicova, N | 1 |
| Hollerova, A | 1 |
| Blahova, J | 1 |
| Mikula, P | 1 |
| Crhanova, M | 1 |
| Karasova, D | 1 |
| Franc, A | 1 |
| Pavlokova, S | 1 |
| Mares, J | 1 |
| Postulkova, E | 1 |
| Tichy, F | 1 |
| Marsalek, P | 1 |
| Lanikova, J | 1 |
| Faldyna, M | 1 |
| Svobodova, Z | 1 |
| McKenna, ZJ | 1 |
| Ducharme, JB | 1 |
| Berkemeier, QN | 1 |
| Specht, JW | 1 |
| Fennel, ZJ | 1 |
| Gillum, TL | 1 |
| Deyhle, MR | 1 |
| Amorim, FT | 1 |
| Mermier, CM | 1 |
| Chen, ZJ | 3 |
| Su, CW | 3 |
| Xiong, S | 3 |
| Li, T | 3 |
| Liang, HY | 3 |
| Lin, YH | 3 |
| Chang, L | 3 |
| Wu, HY | 3 |
| Li, F | 3 |
| Zhu, DY | 3 |
| Luo, CX | 3 |
| Ratajczyk-Socha, N | 1 |
| Olszewski, J | 1 |
| Marcianò, G | 1 |
| Muraca, L | 1 |
| Rania, V | 1 |
| Gallelli, L | 1 |
| Guo, C | 1 |
| Cao, M | 1 |
| Diao, N | 1 |
| Wang, W | 1 |
| Geng, H | 1 |
| Su, Y | 1 |
| Sun, T | 2 |
| Lu, X | 1 |
| Kong, M | 1 |
| Chen, D | 1 |
| Durkan, K | 1 |
| Ichedef, C | 1 |
| Yurt Kilcar, A | 1 |
| Koksal Karayildirim, C | 1 |
| Chen, L | 1 |
| Xie, L | 1 |
| Zhang, J | 1 |
| Feng, Y | 1 |
| Wu, X | 1 |
| Guha, L | 1 |
| Muhammad, W | 1 |
| Zhang, Y | 3 |
| Xie, J | 1 |
| Wang, S | 1 |
| Wang, R | 1 |
| Feng, B | 1 |
| Zhou, J | 1 |
| Chen, W | 1 |
| Xu, Y | 1 |
| Yao, Q | 1 |
| Yu, Y | 1 |
| Cao, H | 1 |
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| Subosic, B | 1 |
| Kotur-Stevuljevic, J | 1 |
| Brboric, J | 1 |
| Jankovic, T | 1 |
| Milenkovic, M | 1 |
| Ivkovic, B | 1 |
| Kostadinovic, J | 1 |
| Savic, J | 1 |
| Li, R | 1 |
| Song, X | 1 |
| Li, G | 1 |
| Hu, Z | 1 |
| Sun, L | 1 |
| Chen, C | 1 |
| Yang, L | 2 |
| McLarnon, JG | 1 |
| Alipour, E | 1 |
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| Yumashev, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Combination of Curcuminoid Standardized Turmeric Extract With Acupressure on Inflammatory Markers, Endorphins and Quality of Life in Elderly People With Osteoarthritis Genu[NCT06105840] | Phase 1/Phase 2 | 70 participants (Anticipated) | Interventional | 2023-08-27 | Enrolling by invitation | ||
| Placebo-controlled, Dose-response Study of Ibuprofen Effects on Brain Function[NCT02507219] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients[NCT04701801] | 200 participants (Actual) | Observational [Patient Registry] | 2020-10-21 | Completed | |||
| Normative Data for the Quick Mild Cognitive Impairment-Taiwan Version (Qmci- TQ) in a Taiwanese Sample[NCT04598178] | 30 participants (Actual) | Observational | 2020-08-04 | Completed | |||
| Efficacy of Perioperative Goal-directed Fluid Therapy in Preventing Cerebral Desaturation and Postoperative Cognitive Dysfunction After Beach Chair Position Shoulder Surgery[NCT03963063] | 70 participants (Actual) | Interventional | 2019-06-27 | Completed | |||
| Postoperative Delirium: a Complex Prediction Model in Patients Undergoing Major Abdominal Surgery[NCT05474872] | 100 participants (Anticipated) | Observational | 2022-07-15 | Recruiting | |||
| Postoperative Ibuprofen Use and Risk of Bleeding in Pediatric Tonsillectomy[NCT03385057] | Phase 1 | 0 participants (Actual) | Interventional | 2018-09-30 | Withdrawn (stopped due to Study design flaws; research design needed to be reconfigured) | ||
| Hypoalgesic Effect of Median Nerve Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02596815] | 51 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Neural Mobilization in Cervicobrachial Pain Compared to a Controlled Group[NCT02595294] | 52 participants (Actual) | Interventional | 2015-07-31 | Completed | |||
| Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721] | Phase 2/Phase 3 | 50 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain[NCT05311774] | 400 participants (Anticipated) | Interventional | 2022-04-30 | Not yet recruiting | |||
| Effect of Milk Fat Globule Membrane (MFGM) on Gut Barrier Protection in Runners[NCT03176212] | 14 participants (Actual) | Interventional | 2012-01-31 | Completed | |||
| Evaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF Subjects[NCT01315665] | 15 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| The Role of IL-17 Neutrophils in CF Lung Inflammation[NCT02025829] | 14 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| The Impact of Aspirin Dose Modification on the Innate Immune Response - Will Lower Dose Aspirin Therapy Reduce the Response to Endotoxin[NCT03869268] | Phase 4 | 72 participants (Actual) | Interventional | 2019-04-24 | Completed | ||
| Evaluation of Postoperative Edema and Pain Following Third Molar Extraction With Application of Pulsed Electromagnetic Field (PEMF) Therapy[NCT02376946] | 49 participants (Actual) | Interventional | 2014-01-31 | Terminated (stopped due to Sponsor decision) | |||
| Efficacy of Steroids on Functional Outcomes After Musculoskeletal Injuries of the Hand[NCT05003596] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in amygdala activation following administration of placebo, 200mg of ibuprofen or 600mg of ibuprofen (NCT02507219)
Timeframe: 3-6 weeks
| Intervention | percent signal change (Mean) | |
|---|---|---|
| Left amygdala | Right amygdala | |
| Ibuprofen, 200mg | 0.21 | 0.23 |
| Ibuprofen, 600mg | 0.23 | 0.17 |
| Placebo | 0.20 | 0.23 |
Change in gingival neutrophils measured after 5 days of study treatment (consuming broccoli sprouts). Patients will perform mouthwashes with normal saline. Neutrophil counts will be performed on fresh samples. Acridine orange will be added to the saline rinses and neutrophils will be counted under the microscope. (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | Neutrophils/mL (Log10) (Mean) |
|---|---|
| Healthy Volunteers | -0.06 |
| Subjects With Cystic Fibrosis | -0.02 |
Change in lymphocyte glutathione measurements after 5 days of study treatment (consuming broccoli sprouts). (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | Micro Molar (Mean) |
|---|---|
| Healthy Volunteers | 14.3 |
| Subjects With Cystic Fibrosis | 4.7 |
Change in urine bromotyrosine (measured by mass spectrometry) will be measured after 5 days of study treatment (consuming broccoli sprouts). (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | ng/mg creatinine (Log10) (Mean) |
|---|---|
| Healthy Volunteers | 0.09 |
| Subjects With Cystic Fibrosis | 0.01 |
Number of subjects with activated Nrf-2 in the cytoplasm of nasal epithelial cells after 5 days of study treatment (consuming broccoli sprouts) (NCT01315665)
Timeframe: Baseline and of end of 5 day treatment period
| Intervention | participants (Number) | |
|---|---|---|
| Baseline | Day 5, End of treatment | |
| Healthy Volunteers | 0 | 4 |
| Subjects With Cystic Fibrosis | 0 | 4 |
In the Exacerbation/IV Antibiotics Cohort--Subjects will serve as their own controls. The percentage of neutrophils (in sputum) positive for IL-17 was determined by flow cytometry for each subject at the beginning and end of treatment for a pulmonary exacerbation. Sputum IL-17 neutrophil counts will be compared to the change in lung function (FEV1) as determined by spirometry (American Thoracic Society standards). (NCT02025829)
Timeframe: End of Treatment, two weeks. Samples will be obtained from each study volunteer at the beginning of IV antibiotic treatment and at the completion of antibiotic treatment for a pulmonary exacerbation
| Intervention | % of neutrophils positive for IL-17 (Mean) |
|---|---|
| Begining of Exacerbation | 55 |
| End of Exacerbation | 4 |
In the Exacerbation/IV Antibiotics Cohort--Measurement of sputum inflammatory mediators by multiplex assay for IL-1β, IL-6, IL-8, and IL-17A. Neutrophil elastase determined by colorimetric assay. Measurements at the beginning of IV antibiotic treatment and after 2 weeks antibiotic treatment for a pulmonary exacerbation (NCT02025829)
Timeframe: End of Treatment, two weeks. Samples will be obtained from each study volunteer at the beginning of IV antibiotic treatment and at the completion of antibiotic treatment for a pulmonary exacerbation
| Intervention | pg/ml (Mean) | ||||
|---|---|---|---|---|---|
| IL-1b (pg/ml) | IL-6 (pg/ml) | IL-8 (pg/ml) | IL-17 (pg/ml) | Neutrophil elastase activity (pg/ml) | |
| Begining of Exacerbation | 2313 | 53 | 5785 | 302 | 195 |
| End of Exacerbation | 757 | 37 | 3428 | 147 | 53 |
24 reviews available for ibuprofen and Inflammation
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Ph | 2019 |
Contemporary advances of cyclic molecules proposed for inflammation.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Humans; Inflammation; Molecular | 2021 |
Metabolomic Studies for Metabolic Alterations Induced by Non-Steroidal Anti-Inflammatory Drugs: Mini Review.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Humans; Ibuprofen; Inflammation; Metabo | 2021 |
Ibuprofen in the Management of Viral Infections: The Lesson of COVID-19 for Its Use in a Clinical Setting.
Topics: Anti-Inflammatory Agents, Non-Steroidal; COVID-19; Humans; Ibuprofen; Inflammation; Pain | 2023 |
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications.
Topics: Aspirin; Drug Repositioning; Humans; Ibuprofen; Inflammation; Spinal Cord Injuries | 2023 |
Consideration of a Pharmacological Combinatorial Approach to Inhibit Chronic Inflammation in Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Dapsone; Drug Therapy, Combination; Humans; Ibuprofen; Inflammation; Min | 2019 |
A narrative review of the potential pharmacological influence and safety of ibuprofen on coronavirus disease 19 (COVID-19), ACE2, and the immune system: a dichotomy of expectation and reality.
Topics: Angiotensin-Converting Enzyme 2; Anti-Inflammatory Agents, Non-Steroidal; Coronavirus Infections; CO | 2020 |
Neuroinflammatory responses in Parkinson's disease: relevance of Ibuprofen in therapeutics.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Humans; Ibuprofen; Inflammation; Neu | 2021 |
Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal.
Topics: Abnormalities, Multiple; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cerebellar Di | 2017 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Surgery, neuroinflammation and cognitive impairment.
Topics: Animals; Brain Injuries, Traumatic; Cognitive Dysfunction; Dementia; Dexmedetomidine; Humans; Hydrox | 2018 |
Ibuprofen in the treatment of children's inflammatory pain: a clinical and pharmacological overview.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Humans; Ibuprofen; Inflamm | 2019 |
Ibuprofen: pharmacology, efficacy and safety.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Child; Dose-Response Relationship, Drug; Fe | 2009 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
Ibuprofen: from invention to an OTC therapeutic mainstay.
Topics: Acute Pain; Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; | 2013 |
[Airway inflammation in cystic fibrosis].
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Humans; Ibuprofen | 2003 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Ibuprofen and Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Ibuprofen | 2004 |
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammator | 2005 |
Inflammation and anti-inflammatory therapies for cystic fibrosis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antioxidants; Cystic Fibrosis; Cytokines; Disease | 2007 |
Inflammation and anti-inflammatory therapies for cystic fibrosis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antioxidants; Cystic Fibrosis; Cytokines; Disease | 2007 |
Inflammation and anti-inflammatory therapies for cystic fibrosis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antioxidants; Cystic Fibrosis; Cytokines; Disease | 2007 |
Inflammation and anti-inflammatory therapies for cystic fibrosis.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antioxidants; Cystic Fibrosis; Cytokines; Disease | 2007 |
Anti-inflammatory agents as inhibitors of prostaglandin synthesis in man.
Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Dru | 1981 |
Nonsteroidal antiinflammatory drugs as inhibitors of periodontal disease progression.
Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Resorption; Flurbiprofen; | 1993 |
Treatment of airway inflammation in cystic fibrosis.
Topics: Administration, Inhalation; Adrenal Cortex Hormones; Age Factors; Anti-Inflammatory Agents; Anti-Inf | 1996 |
Therapies aimed at airway inflammation in cystic fibrosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cystic Fibrosis; Glucocorticoids; Humans; Ibuprofen; In Vit | 1998 |
Kinetics of non-steroidal anti-inflammatory drugs in synovial fluid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Exudates and Transudates; Half-Life; Humans; Ibuprofen; Inf | 1988 |
21 trials available for ibuprofen and Inflammation
| Article | Year |
|---|---|
The effects of pre-emptive intravenous ibuprofen on the thiol/disulfide homeostasis and C-reactive protein level as the markers of oxidative stress and inflammation during gynecologic laparoscopy: A randomised clinical trial.
Topics: Adult; Aged; C-Reactive Protein; Disulfides; Female; Homeostasis; Humans; Ibuprofen; Inflammation; L | 2021 |
NSAID chronotherapy after impacted third molar extraction: a randomized controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chronotherapy; Double-Blind Method; Humans; Ibuprofen; Infl | 2022 |
Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia.
Topics: Adult; Chemokine CCL2; Exercise; Gastrointestinal Diseases; Humans; Hypoxia; Ibuprofen; Inflammation | 2023 |
Miconia albicans and Curcuma longa herbal medicines positively modulate joint pain, function and inflammation in patients with osteoarthritis: a clinical study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Curcuma; Female | 2021 |
Cardio-respiratory Events and Inflammatory Response After Primary Immunization in Preterm Infants < 32 Weeks Gestational Age: A Randomized Controlled Study.
Topics: Apnea; Bradycardia; C-Reactive Protein; Double-Blind Method; Female; Gestational Age; Humans; Ibupro | 2017 |
Effect of Ibuprofen on BrainAGE: A Randomized, Placebo-Controlled, Dose-Response Exploratory Study.
Topics: Adult; Age Factors; Aged; Brain; Cross-Over Studies; Double-Blind Method; Female; Humans; Ibuprofen; | 2018 |
No inflammatory gene-expression response to acute exercise in human Achilles tendinopathy.
Topics: Achilles Tendon; Adult; Anti-Inflammatory Agents, Non-Steroidal; Collagen Type I; Collagen Type III; | 2013 |
Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Colorectal Neoplasms; Early Dete | 2015 |
Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Clinical Trials as Topic; Cystic Fibrosis; Fema | 2015 |
No effect of anti-inflammatory medication on postprandial and postexercise muscle protein synthesis in elderly men with slightly elevated systemic inflammation.
Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Composition; C-Reactive Protein; Cross- | 2016 |
Ibuprofen and acetaminophen: effect on muscle inflammation after eccentric exercise.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non- | 2003 |
Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition.
Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Colony-Stimulating Factors; Cr | 2006 |
Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain.
Topics: Acute Disease; Adolescent; Adult; Anti-Inflammatory Agents; Cyclooxygenase 2 Inhibitors; Cytokines; | 2007 |
Attenuation of C-reactive protein increases after exodontia by tramadol and ibuprofen.
Topics: Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Drug Combina | 2006 |
Clinical response to non-steroidal anti-inflammatory drugs in urate-crystal induced inflammation: a simultaneous study of intersubject and intrasubject variability.
Topics: Adult; Aged; Analysis of Variance; Computer Simulation; Cross-Over Studies; Crystallization; Double- | 1994 |
Effects of cyclo-oxygenase inhibition on ozone-induced respiratory inflammation and lung function changes.
Topics: Adult; Bronchitis; Bronchoalveolar Lavage Fluid; Cyclooxygenase Inhibitors; Double-Blind Method; Hum | 1996 |
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation.
Topics: Adult; Aspirin; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2000 |
Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Carbon Dioxide; Dyspnea; Endotox | 2001 |
Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Edema; Female; Hemostasis; Humans; Ibu | 1975 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Comparison of nonsteroidal anti-inflammatory drugs, ibuprofen and flurbiprofen, with methylprednisolone and placebo for acute pain, swelling, and trismus.
Topics: Adult; Double-Blind Method; Evaluation Studies as Topic; Female; Fever; Flurbiprofen; Humans; Ibupro | 1990 |
Photogrammetry used to assess post-operative facial swelling in a drug trial.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Face; Female; Humans; Ibuprofen; I | 1985 |
182 other studies available for ibuprofen and Inflammation
| Article | Year |
|---|---|
Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Female; Fever; Ibuprofen; Indomethacin; Inflamma | 1984 |
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhib | 2008 |
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibup | 2008 |
Effect of the major glycosides of Harpagophytum procumbens (Devil's Claw) on epidermal cyclooxygenase-2 (COX-2) in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coumaric Acids; Cyclooxygenase 2 Inhibitors; Epide | 2008 |
Design, synthesis and characterization of novel 2-(2,4-disubstituted-thiazole-5-yl)-3-aryl-3H-quinazoline-4-one derivatives as inhibitors of NF-kappaB and AP-1 mediated transcription activation and as potential anti-inflammatory agents.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Design; Humans; Inflammation; Inhibitory Concentration | 2009 |
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.
Topics: Acetylene; Alkynes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Cyc | 2009 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch | 2009 |
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Anti-inflammatory and anti-arthritic effects of new synthetic 3-(4-hydroxyphenyl)-4-(4-thiomethoxyphenyl)-1H-pyrrole-2,5-dione.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Cyclo | 2012 |
Antiallodynic and analgesic effects of maslinic acid, a pentacyclic triterpenoid from Olea europaea.
Topics: Analgesics; Animals; Capsaicin; gamma-Aminobutyric Acid; Hyperalgesia; Inflammation; Mice; Molecular | 2013 |
2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Edema; Flavanones; Inflammation | 2015 |
Discovery of non-zwitterionic aryl sulfonamides as Na
Topics: Administration, Oral; Animals; Chronic Pain; Disease Models, Animal; Dose-Response Relationship, Dru | 2017 |
1-Aryl-1H- and 2-aryl-2H-1,2,3-triazole derivatives blockade P2X7 receptor in vitro and inflammatory response in vivo.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Inflammation; Lipopolysaccharides; Mice; Molec | 2017 |
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.
Topics: Cell Line; Enzyme Inhibitors; Humans; Inflammation; Lipoxygenases; NF-kappa B; Prenylation; Prostagl | 2019 |
Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Topics: Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; | 2019 |
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cattle; Cyclooxygenase 1; Cyclooxy | 2020 |
Pharmacodynamic/pharmacokinetic correlation of optimized ibuprofen nanosuspensions having enhanced anti-inflammatory and antinociceptive activity.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Disease Models, Anim | 2022 |
Design and synthesis of ibuprofen-quinoline conjugates as potential anti-inflammatory and analgesic drug candidates.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cycloox | 2022 |
Ibuprofen-loaded centrifugally spun microfibers for quick relief of inflammation in rats.
Topics: Animals; Calorimetry, Differential Scanning; Ibuprofen; Inflammation; Polymers; Rabbits; Rats; Solub | 2021 |
Ibuprofen-Loaded Electrospun PCL/PEG Nanofibrous Membranes for Preventing Postoperative Abdominal Adhesion.
Topics: Humans; Ibuprofen; Inflammation; Membranes, Artificial; Nanofibers; Tissue Adhesions | 2022 |
Selective terpene based therapeutic deep eutectic systems against colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Colorectal Neoplasms; Humans; Ibuprofen; Inflamm | 2022 |
Rivastigmine Reverses the Decrease in Synapsin and Memory Caused by Homocysteine: Is There Relation to Inflammation?
Topics: Acetylcholinesterase; Animals; Homocysteine; Hyperhomocysteinemia; Ibuprofen; Inflammation; Male; Ox | 2022 |
ROS-responsive copolymer micelles for inflammation triggered delivery of ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Inflammation; Micelles; Polymers; Reacti | 2022 |
Design, Synthesis, and Anti-Inflammatory Activity of Some Coumarin Schiff Base Derivatives: In silico and in vitro Study.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Coumarins; Cyclooxygenase 2; Cycl | 2022 |
Involvement of a neutrophil-mast cell axis in the effects of Piper malacophyllum (C. PESL) C. DC extract and its isolated compounds in a mouse model of dysmenorrhoea.
Topics: Animals; Disease Models, Animal; Dysmenorrhea; Female; Ibuprofen; Inflammation; Mast Cells; Mice; Ne | 2022 |
Comparative study on eucalyptol and camphor rich essential oils from rhizomes of Hedychium spicatum Sm. and their pharmacological, antioxidant and antifungal activities.
Topics: Animals; Antifungal Agents; Antioxidants; Camphor; Eucalyptol; Ibuprofen; Inflammation; Mice; Oils, | 2022 |
Non-steroidal anti-inflammatory drugs caused an outbreak of inflammation and oxidative stress with changes in the gut microbiota in rainbow trout (Oncorhynchus mykiss).
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Diclofenac; Disease Outbreaks; Dysbios | 2022 |
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex; | 2023 |
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex; | 2023 |
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex; | 2023 |
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex; | 2023 |
The analysis of reason for the presence and treatment of chronic inflammation of the paranasal sinuses in own material.
Topics: Acetaminophen; Animals; Cats; Dipyrone; Dogs; Female; Humans; Ibuprofen; Inflammation; Paranasal Sin | 2023 |
Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy.
Topics: Angelica sinensis; Animals; Astragalus Plant; Diabetes Mellitus, Experimental; Diabetic Neuropathies | 2023 |
Topics: Animals; Ibuprofen; Inflammation; Models, Animal; Radionuclide Imaging; Radiopharmaceuticals; Rats; | 2023 |
GC-MS analysis of fatty acid metabolomics in RAW264.7 cell inflammatory model intervened by non-steroidal anti-inflammatory drugs and a preliminary study on the anti-inflammatory effects of NLRP3 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Fatty Acids; Gas Chromatography-Mass Spectrometry; | 2023 |
Co-delivery of azithromycin and ibuprofen by ROS-responsive polymer nanoparticles synergistically attenuates the acute lung injury.
Topics: Acute Lung Injury; Azithromycin; Bacterial Infections; Humans; Ibuprofen; Inflammation; Nanoparticle | 2023 |
Ex vivo and in vivo antioxidant activity of β-hydroxy-β-arylalkanoic acids.
Topics: Antioxidants; Benzene; Humans; Hydroxy Acids; Ibuprofen; Inflammation; Oxidative Stress | 2023 |
Ibuprofen attenuates interleukin-1β-induced inflammation and actin reorganization via modulation of RhoA signaling in rabbit chondrocytes.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chondrocytes; Ibuprofen; | 2019 |
Fullerene C60 containing porphyrin-like metal center as drug delivery system for ibuprofen drug.
Topics: Adsorption; Coordination Complexes; Drug Delivery Systems; Fullerenes; Humans; Ibuprofen; Inflammati | 2019 |
Synthesis of bifunctional carbon quantum dots for bioimaging and anti-inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbon; Carrageenan; Disease Models, Animal; Drug | 2020 |
Ventilatory and carotid body responses to acute hypoxia in rats exposed to chronic hypoxia during the first and second postnatal weeks.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Femal | 2020 |
Ibuprofen increases the serum Omentin levels in rats after abdominal surgery.
Topics: Adipokines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Humans; Ibuprofen; Inflamma | 2020 |
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Animal; | 2021 |
Ibuprofen, a traditional drug that may impact the course of COVID-19 new effective formulation in nebulizable solution.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Antiviral Agents; Burkholderia cepacia; COVID-19 Dr | 2020 |
Memantine and Ibuprofen pretreatment exerts anti-inflammatory effect against streptozotocin-induced astroglial inflammation via modulation of NMDA receptor-associated downstream calcium ion signaling.
Topics: Animals; Anti-Inflammatory Agents; Astrocytes; Calcium; Calcium Signaling; Cell Line, Tumor; Disease | 2021 |
The effects of reducing chronic inflammation in overweight women on serum hepcidin and iron absorption with and without supplemental ascorbic acid.
Topics: Adult; Ascorbic Acid; Female; Hepcidins; Humans; Ibuprofen; Inflammation; Interleukin-6; Intestinal | 2021 |
Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, Animal; Dos | 2021 |
Basic Pharmacological Characterization of EV-34, a New H
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cyclooxygenas | 2021 |
Synthesis of Highly Potent Anti-Inflammatory Compounds (ROS Inhibitors) from Isonicotinic Acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Humans; Ibuprofen; Inflammatio | 2021 |
Tobramycin and Colistin display anti-inflammatory properties in CuFi-1 cystic fibrosis cell line.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Survival; Colistin; | 2021 |
Assessment of pharmacological activities of Lygodium microphyllum Cav. leaves in the management of pain, inflammation, pyrexia, diarrhea, and helminths: In vivo, in vitro and in silico approaches.
Topics: Albendazole; Analgesics; Animals; Anthelmintics; Anti-Inflammatory Agents; Antidiarrheals; Antipyret | 2021 |
Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Carrageenan; Edema; Gastric Mucosa; | 2017 |
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
Topics: Acinar Cells; Animals; Cell Differentiation; Cell Proliferation; Ceruletide; Cytokines; Diclofenac; | 2018 |
Investigating Cyclooxygenase Inhibition in a Rat Pulmonary Contusion Model: A Laboratory Study Finding No Improvement with Ibuprofen.
Topics: Animals; Bronchoalveolar Lavage; Contusions; Cyclooxygenase Inhibitors; Disease Models, Animal; Ibup | 2017 |
Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Capsules; Celecoxib; Cimetidine; Delayed-Action Preparation | 2017 |
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female | 2017 |
Sweet's syndrome: a clinical entity need to discriminate against acute haematogenous periprosthetic joint infection.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthroplasty, Replacement, Knee; Colchicin | 2018 |
Polyunsaturated fatty acids influence inflammatory markers in a cellular model for canine osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Biomarkers; Chondrocytes; Docosa | 2018 |
Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Celecoxib; | 2018 |
The effects of human drugs in Corbicula fluminea. Assessment of neurotoxicity, inflammation, gametogenic activity, and energy status.
Topics: Animals; Biomarkers; Caffeine; Carbamazepine; Corbicula; Energy Metabolism; Germ Cells; Humans; Ibup | 2018 |
Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Benzimidazoles; Carrageenan; Disease | 2018 |
Synthesis, biological evaluation and docking study of N-(2-(3,4,5-trimethoxybenzyl)benzoxazole-5-yl) benzamide derivatives as selective COX-2 inhibitor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Benzamides; Benzoxazoles; Carrageenan; Cycloox | 2018 |
Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.
Topics: Biomarkers; Chemokine CCL2; Ductus Arteriosus, Patent; Echocardiography; Growth Differentiation Fact | 2019 |
Female-biased embryonic death from inflammation induced by genomic instability.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; DNA Damage; DNA Helicases; DNA | 2019 |
Early and late anti nociceptive effects of sucrose on neonatal inflammatory pain in rats: Comparison to a non-steroidal anti-inflammatory drug.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Brain-Derived Neurotrophic Facto | 2019 |
The effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Disease Models, Animal; Ibup | 2019 |
Inhibition of inflammation is not enough for recovery of cognitive impairment in hepatic encephalopathy: Effects of minocycline and ibuprofen.
Topics: Animals; Bile Ducts; Blood-Brain Barrier; Cognition; Cognitive Dysfunction; Disease Models, Animal; | 2019 |
Oral Administration of
Topics: Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Resistance, Neoplasm | 2019 |
Interplay between inflammation and neural plasticity: Both immune activation and suppression impair LTP and BDNF expression.
Topics: Animals; Anti-Inflammatory Agents; Brain-Derived Neurotrophic Factor; Cyclooxygenase Inhibitors; Cyt | 2019 |
Protective effect of ibuprofen in a rat model of chronic oxaliplatin-induced peripheral neuropathy.
Topics: Animals; Antineoplastic Agents; Cytokines; Disease Models, Animal; Ganglia, Spinal; Ibuprofen; Infla | 2019 |
Poly-(ethylene glycol) modified gelatin nanoparticles for sustained delivery of the anti-inflammatory drug Ibuprofen-Sodium: an in vitro and in vivo analysis.
Topics: Anti-Inflammatory Agents; Drug Delivery Systems; Gelatin; Humans; Ibuprofen; Inflammation; Nanoparti | 2013 |
Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Cyclophos | 2013 |
Recurrent nephrogenic adenoma: a case report of resolution after treatment with antibiotics and nonsteroidal anti-inflammatory medication.
Topics: Adenoma; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Child; Endoscopy; H | 2013 |
Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation.
Topics: Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Chronic D | 2014 |
Levetiracetam interacts synergistically with nonsteroidal analgesics and caffeine to produce antihyperalgesia in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Celecoxib; Dr | 2013 |
The chronicity of tonsillitis is significantly correlated with an increase in an LTi cell portion.
Topics: Antigens, Differentiation; CD3 Complex; CD4-Positive T-Lymphocytes; CD56 Antigen; Humans; Ibuprofen; | 2014 |
Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Ceftriaxone; Ce | 2014 |
Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment.
Topics: Adult; Anti-Inflammatory Agents; Drug Resistance; Eicosanoids; Exercise; Fatty Acids, Unsaturated; H | 2013 |
Anti-inflammatory and pharmacokinetics evaluation of PEGylated ibuprofen tablet formulation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Evaluation, Precli | 2014 |
The impact of nonsteroidal anti-inflammatory drugs on inflammatory response after aneurysmal subarachnoid hemorrhage.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; C-Rea | 2014 |
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, A | 2014 |
Regulating inflammation using acid-responsive electrospun fibrous scaffolds for skin scarless healing.
Topics: Animals; Ibuprofen; Inflammation; Lactic Acid; Male; Polyesters; Polymers; Rats; Rats, Sprague-Dawle | 2014 |
Peripheral surgical wounding and age-dependent neuroinflammation in mice.
Topics: Age Factors; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cognition; Cognition Disorder | 2014 |
Characterization of lung inflammation and its impact on macrophage function in aging.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cytokines; Female; Gene Ex | 2014 |
Modulation of oxidative and inflammatory cardiac response by nonselective 1- and 2-cyclooxygenase inhibitor and benznidazole in mice.
Topics: Administration, Oral; Animals; Antioxidants; Catalase; Cyclooxygenase Inhibitors; Dose-Response Rela | 2015 |
Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis.
Topics: Amino Acid Sequence; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Dinopr | 2015 |
Synergistic effects of anethole and ibuprofen in acute inflammatory response.
Topics: Allylbenzene Derivatives; Animals; Anisoles; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; C | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; D | 2016 |
Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adhesives; Administration, Intranasal; Animals; Corpus | 2016 |
Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude.
Topics: Altitude; Animals; Area Under Curve; Cytochrome P-450 CYP2C9; Cytokines; Down-Regulation; Hypoxia; I | 2016 |
Hybrid Compounds Strategy in the Synthesis of Oleanolic Acid Skeleton-NSAID Derivatives.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Infla | 2016 |
Effects of Oxidative Stress and Testosterone on Pro-Inflammatory Signaling in a Female Rat Dopaminergic Neuronal Cell Line.
Topics: Animals; Apoptosis; Caffeic Acids; Cell Line; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dopaminer | 2016 |
PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization.
Topics: Administration, Ophthalmic; Animals; Biological Availability; Cell Death; Cornea; Drug Liberation; I | 2016 |
Ibuprofen in paediatrics: pharmacology, prescribing and controversies.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Female; Humans; Ibupro | 2016 |
Pharmacokinetic Studies of Gel System Containing Ibuprofen Solid Nanoparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Models, Animal; Gel | 2016 |
Synthesis and Study of Analgesic and Anti-inflammatory Activities of Amide Derivatives of Ibuprofen.
Topics: Amides; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Dr | 2017 |
Inflammation: NSAIDs and cardiovascular risk in arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular Diseases; Celecoxib; Humans; Ibup | 2017 |
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BALB 3T3 Cells; Cells, Cultured; Disease Models, A | 2017 |
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Biomarkers; Cognition; Cognitive Aging | 2017 |
Focal inflammatory myositis of the paraspinal neck muscles.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, | 2008 |
N-Pyridinyl(methyl)-indole-1- or 3-propanamides and propenamides acting as topical and systemic inflammation inhibitors.
Topics: Amides; Animals; Dexamethasone; Ibuprofen; Indoles; Inflammation; Mice; Structure-Activity Relations | 2008 |
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Chronic D | 2009 |
Essential nutrients suppress inflammation by modulating key inflammatory gene expression.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cytokines; Dietary Supplements; Dinoprostone; Gene Expr | 2008 |
Neuroinflammation contributes to hypokinesia in rats with hepatic encephalopathy: ibuprofen restores its motor activity.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Excitatory Amino Acid Transp | 2009 |
Ibuprofen and hydrogel-released ibuprofen in the reduction of inflammation-induced migration in melanoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Movement; Delayed-Action Preparations; Huma | 2009 |
Tumor markers and rectal cancer: support for an inflammation-related pathway.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspirin; Biomarkers, Tumor; Cali | 2009 |
Effects of treatments on inflammatory and apoptotic markers in the CNS of mice with globoid cell leukodystrophy.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Apoptosis; Bio | 2009 |
Reduction of low grade inflammation restores blunting of postprandial muscle anabolism and limits sarcopenia in old rats.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Eating; Ibuprofen; Inflammation; Metabolism | 2009 |
Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Bile Ducts; Brain; Cell Movement | 2010 |
Design, synthesis and pharmacological evaluation of novel azole derivatives of aryl acetic acid as anti-inflammatory and analgesic agents.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Drug Design; Gastric Mucosa; Ibuprofen; Inf | 2011 |
APP intracellular domain impairs adult neurogenesis in transgenic mice by inducing neuroinflammation.
Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen; Immunoh | 2010 |
Topical application of compound Ibuprofen suppresses pain by inhibiting sensory neuron hyperexcitability and neuroinflammation in a rat model of intervertebral foramen inflammation.
Topics: Administration, Topical; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Disease Models, An | 2011 |
Dissociation of rewarding, anti-aversive and anti-nociceptive effects of different classes of anti-nociceptives in the rat.
Topics: Analgesics; Animals; Carrageenan; Conditioning, Psychological; Dose-Response Relationship, Drug; gam | 2011 |
Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways.
Topics: Animals; Brain; Brain Edema; Carbachol; Cyclooxygenase Inhibitors; Disease Models, Animal; Ibuprofen | 2010 |
Luteinized unruptured follicle syndrome increased by inactive disease and selective cyclooxygenase 2 inhibitors in women with inflammatory arthropathies.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chi-Square Distribution; Cyclo | 2011 |
Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose | 2011 |
Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain.
Topics: Analgesics, Non-Narcotic; Animals; Arginine; Cold Temperature; Disease Models, Animal; Drug Combinat | 2012 |
Exposure to repetitive tasks induces motor changes related to skill acquisition and inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Female; Forelimb; Hand Strength; | 2011 |
ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
Topics: Activating Transcription Factor 6; Adjuvants, Immunologic; Animals; Anthraquinones; Anti-Inflammator | 2012 |
Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular System; Carotid Bod | 2012 |
Spontaneous burrowing behaviour in the rat is reduced by peripheral nerve injury or inflammation associated pain.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Cyclohexanec | 2012 |
Performance of repetitive tasks induces decreased grip strength and increased fibrogenic proteins in skeletal muscle: role of force and inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Collagen Type I; Connective Tissue Growth Factor; | 2012 |
Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia.
Topics: Animals; Carotid Body; Hypoxia; Ibuprofen; Inflammation; Interleukin-1beta; Rats; Transcription Fact | 2012 |
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil | 2013 |
Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Down-Regu | 2013 |
Role of downstream metabolic processing of proinflammatory fatty acids by 5-lipoxygenase in HL-60 cell apoptosis.
Topics: Apoptosis; Arachidonate 5-Lipoxygenase; Benzoquinones; Cyclooxygenase Inhibitors; DNA Fragmentation; | 2003 |
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Eating; Edema; Estradiol; | 2003 |
Dexibuprofen (S+-isomer ibuprofen) reduces gastric damage and improves analgesic and antiinflammatory effects in rodents.
Topics: Analgesia; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2003 |
Quantitative assessment of markers of inflammation, arthritis and pain in rats with adjuvant arthritis following the treatment with ibuprofen cream and placebo.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental | 2003 |
Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation.
Topics: Action Potentials; Analgesics, Non-Narcotic; Animals; Blotting, Western; Cyclooxygenase 2; Dose-Resp | 2003 |
[Synthesis of (+/-) ibuprofen sugar derivatives].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Ibuprofen; Inflammation; Male; Mice; Molecular Con | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; | 2004 |
Ibuprofen blocks changes in Na v 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat.
Topics: Animals; Cyclooxygenase Inhibitors; Freund's Adjuvant; Ibuprofen; Inflammation; NAV1.7 Voltage-Gated | 2004 |
Efficacy of duloxetine, a potent and balanced serotonergic and noradrenergic reuptake inhibitor, in inflammatory and acute pain models in rodents.
Topics: Adrenergic Uptake Inhibitors; Amines; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Age | 2005 |
Platelet activation in cystic fibrosis.
Topics: Adenylyl Cyclases; Adolescent; Adult; Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Arachido | 2005 |
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Bacterial Pro | 2005 |
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain.
Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic A | 2006 |
Synergistic interactions between the dual serotonergic, noradrenergic reuptake inhibitor duloxetine and the non-steroidal anti-inflammatory drug ibuprofen in inflammatory pain in rodents.
Topics: Acetic Acid; Adrenergic Uptake Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavio | 2007 |
Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupus.
Topics: Animals; Atrophy; Brain; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Ibupro | 2006 |
Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts.
Topics: Ammonia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Hepatic Encephalopathy; Ibupr | 2007 |
Synthesis and evaluation of the antiinflammatory activity of N-[2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-nicotinamide.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Exp | 2007 |
Anti-inflammatory effect of ibuprofen-loaded embolization beads in sheep uterus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Drug Delivery Systems | 2008 |
Evaluation of commonly used adjuvants in the prevention of postoperative adhesions.
Topics: Animals; Dexamethasone; Dextrans; Drug Evaluation; Female; Ibuprofen; Infertility, Female; Inflammat | 1983 |
Ibuprofen in the prevention of experimentally induced postoperative adhesions.
Topics: Abdomen; Animals; Arachidonic Acid; Arachidonic Acids; Collagen; Dose-Response Relationship, Drug; F | 1984 |
Characteristics and effect of antiinflammatory drugs on adriamycin-induced inflammation in the mouse paw.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Capillary Permeability; Diphenhydramine; Doxorubicin; Fe | 1980 |
In vivo interaction of nonsteroidal anti-inflammatory drugs on the locomotion of neutrophils elicited by acute non-specific inflammations in the rat--effect of indomethacin, ibuprofen and flurbiprofen.
Topics: Animals; Anti-Inflammatory Agents; Blood; Calcium Pyrophosphate; Chemotaxis, Leukocyte; Flurbiprofen | 1984 |
The effect of ibuprofen on accumulation of indium-111-labeled platelets and leukocytes in experimental myocardial infarction.
Topics: Animals; Blood Platelets; Dogs; Ibuprofen; Indium; Inflammation; Isotope Labeling; Leukocytes; Myoca | 1982 |
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero | 1981 |
Pharmacodynamic comparison of regional drug delivery for non-steroidal anti-inflammatory drugs, using the rat air-pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Ibuprofen; Inflammation; Male; Pirox | 1995 |
Paradoxic effect of ibuprofen on neutrophil accumulation in pulmonary and cutaneous inflammation.
Topics: Animals; Complement C5a; Female; Fluorescent Antibody Technique; Ibuprofen; Inflammation; Lung; Male | 1995 |
The six-day-old rat air pouch model of inflammation: characterization of the inflammatory response to carrageenan.
Topics: Animals; Carrageenan; Dinoprostone; Dose-Response Relationship, Drug; Exudates and Transudates; Gran | 1994 |
Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation.
Topics: Animals; Carrageenan; Chromatography, High Pressure Liquid; Disease Models, Animal; Drug Delivery Sy | 1994 |
Effects of nonsteroidal anti-inflammatory drugs on microvascular dynamics.
Topics: Administration, Topical; Animals; Endothelium, Vascular; Ibuprofen; Indomethacin; Inflammation; Leuk | 1993 |
Effect of ibuprofen on the inflammatory response to surgical wounds.
Topics: Animals; Burns; Cecum; Dermatologic Surgical Procedures; Ibuprofen; Immune Tolerance; Inflammation; | 1993 |
Role of xanthine oxidase and prostaglandins in inflammatory-induced bacterial translocation.
Topics: Allopurinol; Animals; Bacterial Physiological Phenomena; Enzyme Activation; Ibuprofen; Inflammation; | 1993 |
Regional drug delivery I: permeability characteristics of the rat 6-day-old air pouch model of inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Delivery Systems; Ibuprofen; Inflammation; Mo | 1995 |
Anti-inflammatory, analgesic and ulcerogenic properties of S-(+)-ibuproxam, racemic ibuproxam-beta-cyclodextrin and S-(+)-ibuproxam-beta-cyclodextrin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzeneacetamides; beta-Cyclodextrins; Cyclodextri | 1996 |
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; | 1996 |
The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Connective | 1997 |
Ibuprofen: new explanation for an old phenomenon.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Humans; Ibuprofen; Inflammation; NF-kappa B | 1999 |
In vitro prostanoid release from spinal cord following peripheral inflammation: effects of substance P, NMDA and capsaicin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Capsaicin; Carrageenan; Cyclooxygenase Inhibitors; Dinoprosto | 1999 |
The role of prostanoids and nitric oxide in endotoxin-induced hyporesponsiveness of equine digital blood vessels.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Culture Techniques; Cycloheximide; Cyclooxygen | 1999 |
Pharmacoepidemiology of non-steroidal anti-inflammatory drug use in Nottingham general practices.
Topics: Adolescent; Adult; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Drug Pres | 2000 |
Effect of ibuprofen and diethylcarbamazine on the hemodynamic and inflammatory response to endotoxin in the dog.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Catheterization; Diethylcarbamazine; Dogs; Endotox | 2000 |
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Mod | 2000 |
Isoprostanes induce plasma extravasation in rat skin.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprost; Dinoprostone; Evans Blue; Extravasation of Diagnostic | 2000 |
Activity profile of glycolamide ester prodrugs of ibuprofen.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Esters; | 2001 |
Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; Calciton | 2001 |
Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Che | 2001 |
A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Mod | 1992 |
Use of the rat air pouch model of inflammation to evaluate regional drug delivery.
Topics: Animals; Carrageenan; Dinoprostone; Ibuprofen; Inflammation; Injections, Intravenous; Male; Rats; Ra | 1992 |
Early postburn lipid peroxidation: effect of ibuprofen and allopurinol.
Topics: Allopurinol; Animals; Burns; Disease Models, Animal; Edema; Ibuprofen; Inflammation; Lipid Peroxidat | 1990 |
Aging, diet, and the acute-phase response to inflammation.
Topics: Acute-Phase Reaction; Aging; Animals; Anorexia; Brain; Carbohydrate Metabolism; Citrates; Diet; Drug | 1989 |
Sulphur dioxide-induced airway hyperreactivity and pulmonary inflammation in dogs.
Topics: Animals; Dogs; Female; Histamine; Ibuprofen; Inflammation; Lung; Lung Diseases; Macrophages; Male; N | 1989 |
Interleukin-1-induced anorexia in the rat. Influence of prostaglandins.
Topics: Animals; Anorexia; Brain Stem; Eating; Feeding and Eating Disorders; Ibuprofen; Inflammation; Interl | 1989 |
Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest.
Topics: Animals; Brain Ischemia; Dogs; Heart Arrest; Ibuprofen; Inflammation; Random Allocation; Resuscitati | 1986 |
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Ibuprofen; Imidazoles; Indomethac | 1986 |
Arachidonic acid-induced inflammation: inhibition by dual inhibitor of arachidonic acid metabolism, SK&F 86002.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Ibuprofen; Imidazoles; Infla | 1987 |
Modification of certain inflammation-induced biochemical changes by curcumin.
Topics: Acid Phosphatase; Adenosine Triphosphatases; Adrenal Glands; Animals; Anti-Inflammatory Agents; Cate | 1985 |
Differential in vivo effects of indomethacin, ibuprofen, and flurbiprofen on oxygen-dependent killing activities of neutrophils elicited by acute nonimmune inflammation in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Flurbiprofen; Ibuprofen; Indomethacin; Inflammatio | 1988 |
Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dinoprostone; Disease Models, Animal; Ibuprofen; Inflammation | 1985 |
Free radicals in ischemic myocardial injury.
Topics: Animals; Arachidonate Lipoxygenases; Catalase; Coronary Disease; Dogs; Free Radicals; Ibuprofen; Inf | 1985 |
Effect of ibuprofen and indomethacin on the O2 supply/consumption balance in ischemic rabbit myocardium.
Topics: Animals; Anti-Inflammatory Agents; Coronary Circulation; Coronary Disease; Heart; Ibuprofen; Indomet | 1985 |
][A new method for screening of analgesics applied to heat induced inflammatory pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab | 1974 |