Page last updated: 2024-10-28

ibuprofen and Infant, Premature, Diseases

ibuprofen has been researched along with Infant, Premature, Diseases in 96 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Infant, Premature, Diseases: Diseases that occur in PREMATURE INFANTS.

Research Excerpts

ExcerptRelevanceReference
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."7.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure."5.39Pulmonary hypertension in an infant treated with ibuprofen. ( Kumarshingri, PS; Sehgal, A, 2013)
"Course of sepsis was evaluated by CRP and IL-6 levels."5.38The effects of ibuprofen on sepsis parameters in preterm neonates. ( Canpolat, FE; Celik, IH; Demirel, G; Dilmen, U; Erdeve, O; Oguz, SS, 2012)
"Pulmonary hypertension is a rare but potentially fatal complication of ibuprofen administration in preterm infants."5.38Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates. ( Aghai, ZH; Amendolia, B; Bhat, V; Lynn, M; Ritz, SB, 2012)
"This study aims to determine whether or not treatment of preterm neonates with PDA using IV ibuprofen can impair renal function and in what range of birth weights and gestational ages the risk of major renal side-effects due to ibuprofen is highest."5.17Treatment of patent ductus arteriosus (PDA) using ibuprofen: renal side-effects in VLBW and ELBW newborns. ( Bagnoli, F; Casucci, M; Messina, G; Mori, A; Rossetti, A; Tomasini, B, 2013)
"Ibuprofen therapy on the third day of life is as efficacious as indomethacin for the treatment of patent ductus arteriosus in preterm infants with the respiratory distress syndrome and is significantly less likely to induce oliguria."5.09A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus. ( Degroote, K; Langhendries, JP; Lecoutere, D; Smets, K; Van de Broek, H; Van Overmeire, B; Weyler, J, 2000)
"Gastrointestinal complications observed in infants treated with ibuprofen for PDA including gastrointestinal perforations occur in less mature infants."3.96Adverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates. ( Berthiller, J; Bouamari, H; Claris, O; Ndour, D; Nguyen, KA; Plaisant, F, 2020)
"Hypertension during pregnancy, even without intrauterine growth restriction, appeared to carry the same risk for MRB as exposure to ibuprofen and extrauterine growth restriction."3.79Risk factors of mild rectal bleeding in very low birth weight infants: a case control study. ( Ben Said, M; Hays, S; Jordan, I; Maucort-Boulch, D; Oulmaati, A; Picaud, JC, 2013)
"To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA."3.79Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013)
"A prospective study with subjects serving as their own controls was performed on <30 weeks' gestational age infants with unconjugated hyperbilirubinemia and who received ibuprofen for patent ductus arteriosus."3.77Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants. ( Amin, SB; Miravalle, N, 2011)
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."3.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"The question of whether to treat patent ductus arteriosus (PDA) early or wait until symptoms appear remains high on the research agenda for neonatal medicine."3.01Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial. ( Bell, JL; Edwards, C; Field, D; Gupta, S; Hardy, P; Hutchison, E; Johnson, S; Juszczak, E; Kelsall, W; Laube, M; Linsell, L; Pepperell, J; Roberts, T; Sinha, S; Stanbury, K; Subhedar, N; Wyllie, J, 2021)
"Echocardiographically guided ibuprofen treatment of patent ductus arteriosus is feasible and reduces unnecessary doses of medication."2.79Randomised controlled clinical trial of standard versus echocardiographically guided ibuprofen treatment for patent ductus arteriosus in preterm infants: a pilot study. ( Bravo, MC; Cabañas, F; Pellicer, A; Pérez-Fernández, E; Pérez-Rodríguez, J; Quero, J; Riera, J, 2014)
" Target concentration approach by the evaluation of trough level may be applicable to real-time dosing strategy."2.78The relationship between trough drug concentrations and ductal closure in preterm infants treated with three-dose-oral ibuprofen. ( Dilmen, U; Erdeve, O; Oncel, MY; Ozdemir, R; Yurttutan, S, 2013)
"Ibuprofen levels were detectable 1 h after administration, peaked after 8 h and remained in a relative plateau until 24 h postadministration."2.77Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants. ( Baram, S; Barzilay, B; Batash, D; Berkovitch, M; Goldman, M; Heyman, E; Keidar, R; Youngster, I, 2012)
"Ibuprofen treatment had no effect on TB, UB, or Ka values."2.77Unbound bilirubin does not increase during ibuprofen treatment of patent ductus arteriosus in preterm infants. ( Barbier, A; Bordarier, C; Desfrere, L; Kibleur, Y; Moriette, G; Thibaut, C, 2012)
"Ibuprofen treatment within the first 5 days of life was indicated when at least two out of four conventional echocardiography criteria were observed: ductal diameter >2 mm, left-right ductal shunt maximum velocity <2 m/sec, mean flow velocity in left pulmonary artery >0."2.77Echocardiography as a guide for patent ductus arteriosus ibuprofen treatment and efficacy prediction. ( Boubred, F; Desandes, E; Desandes, R; Haddad, F; Hascoët, JM; Jellimann, JM; Rouabah, M; Semama, DS; Vieux, R, 2012)
"Indomethacin is widely accepted as the treatment for patent ductus arteriosus (PDA) in preterm infants but it has various side effects."2.71A comparison of oral ibuprofen and intravenous indomethacin for closure of patent ductus arteriosus in preterm infants. ( Chotigeat, U; Jirapapa, K; Layangkool, T, 2003)
"59 liters/kg), but the median serum half-life (16."2.71Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life. ( Allegaert, K; Cossey, V; Devlieger, H; Langhendries, JP; Naulaers, G; Van Overmeire, B; Vanhole, C, 2004)
"The occurrence of patent ductus arteriosus was less frequent only on day 3 of life in the ibuprofen group."2.71Prophylactic ibuprofen for the prevention of intraventricular hemorrhage among preterm infants: a multicenter, randomized study. ( Bertini, G; Dani, C; Guerrini, P; Martano, C; Pezzati, M; Poggi, C; Rubaltelli, FF, 2005)
"Ibuprofen has recently been shown to be effective in closing PDA with fewer hemodynamic effects."2.71[Ibuprofen versus indomethacin in the treatment of patent ductus arteriosus in preterm infants]. ( Cano Sánchez, A; Carrasco Moreno, JI; Fernández Gilino, C; Gimeno Navarro, A; Gutiérrez Laso, A; Izquierdo Macián, I; Morcillo Sopena, F, 2005)
"Ibuprofen treatment significantly reduced plasma levels of prostaglandins, and the levels remained low for 72 hours in newborns who received three doses of the drug."2.68Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants. ( Aranda, JV; Bardin, CL; Beharry, K; Chemtob, S; Papageorgiou, A; Varvarigou, A, 1996)
""Patent ductus arteriosus is one of most common problems that physicians caring for preterm infants have to face."2.47Patent ductus arteriosus: wait and see? ( Ciarmoli, E; Mosca, F; Schena, F, 2011)
"The persistence of a patent ductus arteriosus (PDA) in preterm infants complicates their clinical course and may contribute to increased morbidity."2.46Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants. ( Gouyon, JB; Kibleur, Y, 2010)
"Indomethacin has long been the drug of choice."2.45Therapeutic closure of the ductus arteriosus: benefits and limitations. ( Boubred, F; Mercanti, I; Simeoni, U, 2009)
" The drug has prolonged elimination (plasma half-life = ca 23 hours), suggesting that once daily dosing is appropriate."2.43Systematic review: intravenous Ibuprofen in preterm newborns. ( Aranda, JV; Thomas, R, 2006)
"To describe the diagnosis and treatment of patent ductus arteriosus (PDA) in infants born at <32 weeks' gestational age (GA) in England and Wales between 2010 and 2017."1.72Management of patent ductus arteriosus in very preterm infants in England and Wales: a retrospective cohort study. ( Al-Turkait, A; Choonara, I; Ojha, S; Szatkowski, L, 2022)
"Patent ductus arteriosus is a common problem frequently encountered in preterm infants."1.48Reopening of the ductus arteriosus in preterm infants; Clinical aspects and subsequent consequences. ( Atay, FY; Buyuktiryaki, M; Halil, H; Oncel, MY; Uras, N, 2018)
" All four participating neonatal ICU had a comparable number of preterm infants; however, differences were observed in the incidence of treatment (33-63%), choice and dosing of medication (ibuprofen or indomethacin), number of pharmacological courses (1-4), and the need for surgical ligation after failure of pharmacological treatment (8-52%)."1.46Using benchmarking to identify inter-centre differences in persistent ductus arteriosus treatment: can we improve outcome? ( Andriessen, P; de Boode, WP; de Vries, WB; Dijkman, KP; Jansen, EJS; van Lingen, RA; Vijlbrief, DC, 2017)
"And ibuprofen treatment did not negatively influence renal and mesenteric oxygenation and extraction in infants with PDA (p > 0."1.40Renal and mesenteric tissue oxygenation in preterm infants treated with oral ibuprofen. ( Altug, N; Dilmen, U; Guzoglu, N; Oguz, SS; Ozdemir, R; Sari, FN; Uras, N, 2014)
"Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure."1.39Pulmonary hypertension in an infant treated with ibuprofen. ( Kumarshingri, PS; Sehgal, A, 2013)
"The effect of patent ductus arteriosus (PDA) treatment with cyclooxygenase (COX) inhibitors (indomethacin [INDO] and ibuprofen [IBU]) on regional oxygenation requires further clarification."1.38Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation? ( Bhatt, M; Mehta, R; Petrova, A, 2012)
"Pulmonary hypertension is a rare but potentially fatal complication of ibuprofen administration in preterm infants."1.38Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates. ( Aghai, ZH; Amendolia, B; Bhat, V; Lynn, M; Ritz, SB, 2012)
"Course of sepsis was evaluated by CRP and IL-6 levels."1.38The effects of ibuprofen on sepsis parameters in preterm neonates. ( Canpolat, FE; Celik, IH; Demirel, G; Dilmen, U; Erdeve, O; Oguz, SS, 2012)
"In ibuprofen group, there was no correlation of AQP2 level with urinary osmolality."1.37Urinary aquaporin-2 excretion during ibuprofen or indomethacin treatment in preterm infants with patent ductus arteriosus. ( Aperia, A; Casper, C; Li, Y; Marcoux, MO; Plat-Willson, G; Zelenina, M, 2011)
"Ibuprofen treatment caused a significant decrease in urinary AVP (UAVP/Ucr 24."1.33Urinary ET-1, AVP and sodium in premature infants treated with indomethacin and ibuprofen for patent ductus arteriosus. ( Faggian, D; Favaro, F; Lago, P; Plebani, M; Trevisanuto, D; Vedovato, S; Zanardo, V, 2005)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (5.21)18.2507
2000's30 (31.25)29.6817
2010's52 (54.17)24.3611
2020's9 (9.38)2.80

Authors

AuthorsStudies
Martini, S1
Vitali, F1
Capelli, I1
Donadei, C1
Raschi, E1
Aiello, V1
Corvaglia, L1
De Ponti, F1
Poluzzi, E1
Galletti, S1
Al-Turkait, A1
Szatkowski, L1
Choonara, I1
Ojha, S1
Höck, M1
Sappler, M1
Hammerl, M1
Griesmaier, E1
Ndayisaba, JP1
Schreiner, C1
Pupp-Peglow, U1
Kiechl-Kohlendorfer, U1
Neubauer, V1
Carneiro, L1
Bouissou, A1
Favrais, G1
Ndour, D1
Bouamari, H1
Berthiller, J1
Claris, O1
Plaisant, F1
Nguyen, KA1
El-Khuffash, A1
Bussmann, N1
Breatnach, CR1
Smith, A1
Tully, E1
Griffin, J1
McCallion, N1
Corcoran, JD1
Fernandez, E1
Looi, C1
Cleary, B1
Franklin, O1
McNamara, PJ1
Gupta, S1
Juszczak, E1
Hardy, P1
Subhedar, N1
Wyllie, J1
Kelsall, W1
Sinha, S1
Johnson, S1
Roberts, T1
Hutchison, E1
Pepperell, J1
Linsell, L1
Bell, JL1
Stanbury, K1
Laube, M1
Edwards, C1
Field, D1
Yurttutan, S3
Gullu, UU1
Samiee-Zafarghandy, S1
van Donge, T1
Fusch, G1
Pfister, M1
Jacob, G1
Atkinson, A1
Rieder, MJ1
Smit, C1
Van Den Anker, J1
Jansen, EJS1
Dijkman, KP2
van Lingen, RA1
de Vries, WB1
Vijlbrief, DC2
de Boode, WP2
Andriessen, P1
Huang, X1
Wang, F1
Wang, K1
El-Farrash, RA1
El Shimy, MS1
El-Sakka, AS1
Ahmed, MG1
Abdel-Moez, DG1
Hundscheid, T1
Onland, W1
van Overmeire, B4
Dijk, P1
van Kaam, AHLC1
Kooi, EMW1
Villamor, E1
Kroon, AA1
Visser, R1
de Tollenaer, SM1
Cools, F1
van Laere, D1
Johansson, AB1
Hocq, C1
Zecic, A1
Adang, E1
Donders, R1
de Vries, W1
van Heijst, AFJ1
Halil, H1
Buyuktiryaki, M2
Atay, FY1
Oncel, MY3
Uras, N4
Olsson, KW1
Larsson, A1
Jonzon, A1
Sindelar, R1
Kaur, S1
Stritzke, A1
Soraisham, AS2
Guler Kazanci, E1
Unsal, H1
Tayman, C1
Sallmon, H1
Aydin, T1
Hort, S1
Kubinski, A1
Bode, C1
Klippstein, T1
Endesfelder, S1
Bührer, C1
Koehne, P1
Erdeve, O4
Ozdemir, R3
Dilmen, U5
Guzoglu, N1
Sari, FN1
Oguz, SS3
Altug, N3
Bravo, MC1
Cabañas, F2
Riera, J1
Pérez-Fernández, E1
Quero, J1
Pérez-Rodríguez, J1
Pellicer, A2
Oulmaati, A1
Hays, S1
Ben Said, M1
Maucort-Boulch, D1
Jordan, I1
Picaud, JC1
Coceani, F1
ElHassan, NO1
Bird, TM1
King, AJ1
Ambadwar, PB1
Jaquiss, RD1
Kaiser, JR1
Robbins, JM1
Lu, D1
Liu, Y1
Tong, X1
Bourgoin, L1
Cipierre, C1
Hauet, Q1
Basset, H1
Gournay, V1
Rozé, JC1
Flamant, C1
Gascoin, G1
Vettukattil, JJ1
Haw, MP1
Kalani, M1
Shariat, M1
Khalesi, N1
Farahani, Z1
Ahmadi, S1
Zanardo, V2
Vedovato, S2
Chiozza, L1
Faggian, D2
Favaro, F2
Trevisanuto, D2
Pereira-da-Silva, L1
Pita, A1
Virella, D1
Serelha, M1
Golombek, SG1
Sola, A1
Baquero, H1
Borbonet, D1
Fajardo, C1
Goldsmit, G1
Lemus, L1
Miura, E1
Pérez, JM1
Rogido, M1
Zambosco, G1
Zecca, E1
Romagnoli, C2
De Carolis, MP2
Costa, S1
Marra, R1
De Luca, D1
Richards, J1
Johnson, A1
Fox, G1
Campbell, M1
Mercanti, I1
Boubred, F2
Simeoni, U1
Aranda, JV3
Beharry, KD1
Valencia, GB1
Benitz, WE1
Jones, LJ1
Craven, PD1
Attia, J1
Thakkinstian, A1
Wright, I1
Longini, M1
Perrone, S1
Vezzosi, P1
Proietti, F1
Marzocchi, B1
Buonocore, G1
Fanos, V2
Antonucci, R1
Brunoldi, E1
Amin, SB1
Miravalle, N1
Bagnoli, F2
Rossetti, A2
Casucci, M2
Mori, A2
Gokmen, T1
Li, Y1
Zelenina, M1
Plat-Willson, G1
Marcoux, MO1
Aperia, A1
Casper, C1
Gouyon, JB1
Kibleur, Y2
Brissaud, O1
Guichoux, J1
Desandes, R1
Jellimann, JM1
Rouabah, M1
Haddad, F1
Desandes, E1
Semama, DS1
Vieux, R1
Hascoët, JM1
Thibaut, C2
Hazard, A1
Huon, C1
Desfrere, L3
Dani, C3
Schena, F1
Ciarmoli, E1
Mosca, F4
Barzilay, B1
Youngster, I1
Batash, D1
Keidar, R1
Baram, S1
Goldman, M1
Berkovitch, M1
Heyman, E1
Demirel, G1
Celik, IH1
Canpolat, FE1
Barbier, A1
Bordarier, C1
Moriette, G2
Bersani, I1
De Rosa, G1
Cota, F1
Roberts, C1
Berrington, J1
Embleton, N1
Dhami, S1
Amitai, Y1
Hammerman, C2
Pusceddu, M1
Dessì, A1
Marcialis, MA1
Adrouche-Amrani, L1
Green, RS1
Gluck, KM1
Lin, J1
Bin-Nun, A1
Kaplan, M1
Bhatt, M1
Petrova, A1
Mehta, R1
Amendolia, B1
Lynn, M1
Bhat, V1
Ritz, SB1
Aghai, ZH1
El-Khuffash, AF1
Mertens, L1
Ekmen, S1
Sehgal, A1
Kumarshingri, PS1
van der Lugt, NM1
Lopriore, E1
Bökenkamp, R1
Smits-Wintjens, VE1
Steggerda, SJ1
Walther, FJ1
Messina, G1
Tomasini, B1
Zhang, CC1
Cheng, GQ1
Sivanandan, S1
Bali, V1
Harabor, A1
Kamaluddeen, M1
Schmidt, B1
Wright, LL1
Davis, P1
Solimano, A1
Roberts, RS1
Bray, M3
Stucchi, I1
Fumagalli, M3
Supapannachart, S1
Limrungsikul, A1
Khowsathit, P1
Morley, GM1
Su, PH1
Chen, JY1
Su, CM1
Huang, TC1
Lee, HS1
Chotigeat, U1
Jirapapa, K1
Layangkool, T1
Allegaert, K1
Cossey, V1
Langhendries, JP2
Naulaers, G1
Vanhole, C1
Devlieger, H1
Distefano, G1
Zohar, S1
Morville, P1
Brunhes, A1
Chevret, S1
Pons, G1
Rey, E1
Treluyer, JM1
Bertini, G2
Pezzati, M2
Poggi, C1
Guerrini, P1
Martano, C1
Rubaltelli, FF2
Lago, P1
Plebani, M1
Gimeno Navarro, A1
Cano Sánchez, A1
Fernández Gilino, C1
Carrasco Moreno, JI1
Izquierdo Macián, I1
Gutiérrez Laso, A1
Morcillo Sopena, F1
Jaillard, S1
Larrue, B1
Rakza, T1
Magnenant, E1
Warembourg, H1
Storme, L1
Bellini, C1
Campone, F1
Serra, G1
Thomas, R1
Vanhaesebrouck, S1
Zonnenberg, I1
Vandervoort, P1
Bruneel, E1
Van Hoestenberghe, MR1
Theyskens, C1
Cherif, A1
Jabnoun, S1
Khrouf, N1
Su, BH1
Lin, HC1
Chiu, HY1
Hsieh, HY1
Chen, HH1
Tsai, YC1
van den Anker, JN1
Patel, J1
Marks, KA1
Roberts, I1
Azzopardi, D1
Edwards, AD1
Varvarigou, A1
Bardin, CL1
Beharry, K1
Chemtob, S1
Papageorgiou, A1
Lattanzio, M1
Tosetto, C1
Colnaghi, MR1
Compagnoni, G1
Vangi, V1
Biagiotti, R1
Cianciulli, D1
Smets, K1
Lecoutere, D1
Van de Broek, H1
Weyler, J1
Degroote, K1
Clyman, RI1
Casalaz, D1
Drukker, A1
Guignard, JP1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Drug Utilization Patterns in Neonatal Units in the UK: a Retrospective Pharmaco-epidemiological Study[NCT03773289]642,729 participants (Actual)Observational2018-04-20Completed
Comparison Between the Effect of Oral Paracetamol Versus Oral Ibuprofen in the Treatment of Patent Ductus Arteriosus in Preterm and Low Birth Weight Infants[NCT03265782]Phase 430 participants (Actual)Interventional2015-06-30Active, not recruiting
Multi-center, Randomized Non-inferiority Trial of Early Treatment Versus Expectative Management of Patent Ductus Arteriosus in Preterm Infants (BeNeDuctus Trial - Belgium Netherlands Ductus Trial)[NCT02884219]273 participants (Actual)Interventional2016-12-23Completed
The Best Treatment Strategy: Surgical Versus Pharmacological, to Close the Ductus Arteriosus Persistent in Preterm Infants. A Randomized Controlled Trial[NCT02602054]Phase 240 participants (Anticipated)Interventional2015-10-31Recruiting
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022]Phase 120 participants (Actual)Interventional2017-06-12Completed
Comparison of the Efficacy of IV Acetaminophen Versus IV Indomethacin in Treatment of Hemodynamically Significant PDA in VLBW Infants[NCT03537144]Phase 337 participants (Actual)Interventional2016-06-30Terminated (stopped due to Difficulty enrolling patients)
Oral Ibuprofen Prophylaxis for Patent Ductus Arterioses in Very Extremely Low Birth Weight Infants[NCT01400737]200 participants (Anticipated)Interventional2011-07-31Recruiting
Ibuprofen and Renal Function in Premature Infants[NCT00217191]Phase 4120 participants Interventional2004-09-30Completed
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
Paracetamol (Acetaminophen) for Closure of PDA in Preterm Infants[NCT01755728]Phase 319 participants (Actual)Interventional2013-01-01Completed
Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial.[NCT02056223]Phase 2/Phase 3120 participants (Anticipated)Interventional2017-01-09Suspended (stopped due to We enrolled only 53 patients)
Randomized Pilot Study Comparing Oral Ibuprofen With Intravenous Ibuprofen in Very Low Birth Weight Infants With Patent Ductus Arteriosus[NCT00642330]Phase 462 participants (Actual)Interventional2007-01-31Completed
Long Term Follow-up of the TREOCAPA (Prophylactic TREatment Of the duCtus Arteriosus in Preterm Infants by Acetaminophen) Study (TREOCAPA-LT)[NCT06064825]500 participants (Anticipated)Observational2023-11-30Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

17 reviews available for ibuprofen and Infant, Premature, Diseases

ArticleYear
Paracetamol versus ibuprofen for the treatment of patent ductus arteriosus in preterm neonates: a meta-analysis of randomized controlled trials.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2018, Volume: 31, Issue:16

    Topics: Acetaminophen; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infant, Newborn; Infant, Premat

2018
Therapeutic manipulation of the ductus arteriosus: current options and future prospects.
    Polskie Archiwum Medycyny Wewnetrznej, 2014, Volume: 124, Issue:1-2

    Topics: Ductus Arteriosus, Patent; Female; Forecasting; Hemodynamics; Humans; Ibuprofen; Indomethacin; Infan

2014
Surgical Intervention in Preterm Neonates with Patent Ductus Arteriosus.
    Current pediatric reviews, 2016, Volume: 12, Issue:2

    Topics: Bronchopulmonary Dysplasia; Combined Modality Therapy; Cyclooxygenase Inhibitors; Ductus Arteriosus,

2016
Therapeutic closure of the ductus arteriosus: benefits and limitations.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Evidence-Based Medicine; Gestati

2009
Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Hemorrhage; Humans; Ibuprofen; I

2009
Treatment of persistent patent ductus arteriosus in preterm infants: time to accept the null hypothesis?
    Journal of perinatology : official journal of the California Perinatal Association, 2010, Volume: 30, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiac Surgical Procedures; Confidence Intervals; Ductus A

2010
Network meta-analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:1

    Topics: Cardiovascular Agents; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprof

2011
Efficacy and tolerability of enteral formulations of ibuprofen in the treatment of patent ductus arteriosus in preterm infants.
    Clinical therapeutics, 2010, Volume: 32, Issue:10

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Ductus Arte

2010
Effect of ibuprofen on bilirubin-albumin binding during the treatment of patent ductus arteriosus in preterm infant.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24 Suppl 3

    Topics: Albumins; Anti-Inflammatory Agents, Non-Steroidal; Bilirubin; Ductus Arteriosus, Patent; Humans; Ibu

2011
New therapeutic strategies for the treatment of patent ductus arteriosus in preterm infants.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newbo

2011
Patent ductus arteriosus: wait and see?
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin;

2011
Should we definitively abandon prophylaxis for patent ductus arteriosus in preterm new-borns?
    Clinics (Sao Paulo, Brazil), 2011, Volume: 66, Issue:12

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Extre

2011
Managing the patent ductus arteriosus in the premature neonate: a new look at what we thought we knew.
    Seminars in perinatology, 2012, Volume: 36, Issue:2

    Topics: Acetaminophen; Biomarkers; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Echocardiogr

2012
[Progresses in treatment of patent ductus arteriosus in premature infants].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:11

    Topics: Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Low Birth Wei

2012
[The pharmacological manipulation of Botallo's duct in the duct-dependent congenital cardiopathies and in the preterm infants with respiratory distress. A review and personal findings].
    Minerva pediatrica, 2005, Volume: 57, Issue:1

    Topics: Alprostadil; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Agents; Cerebral Angiography; C

2005
Systematic review: intravenous Ibuprofen in preterm newborns.
    Seminars in perinatology, 2006, Volume: 30, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indom

2006
Use of ibuprofen in paediatric populations.
    Journal of the Royal Society of Medicine, 2007, Volume: 100 Suppl 48

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chickenpox; Child; Fever; Humans; Ibuprofen; Infant, Newbor

2007

Trials

26 trials available for ibuprofen and Infant, Premature, Diseases

ArticleYear
A Pilot Randomized Controlled Trial of Early Targeted Patent Ductus Arteriosus Treatment Using a Risk Based Severity Score (The PDA RCT).
    The Journal of pediatrics, 2021, Volume: 229

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infan

2021
Study protocol: baby-OSCAR trial: Outcome after Selective early treatment for Closure of patent ductus ARteriosus in preterm babies, a multicentre, masked, randomised placebo-controlled parallel group trial.
    BMC pediatrics, 2021, 02-26, Volume: 21, Issue:1

    Topics: Bronchopulmonary Dysplasia; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Low Birth

2021
Efficacy and safety of oral paracetamol versus oral ibuprofen for closure of patent ductus arteriosus in preterm infants: a randomized controlled trial.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2019, Volume: 32, Issue:21

    Topics: Acetaminophen; Administration, Oral; Case-Control Studies; Double-Blind Method; Ductus Arteriosus, P

2019
Early treatment versus expectative management of patent ductus arteriosus in preterm infants: a multicentre, randomised, non-inferiority trial in Europe (BeNeDuctus trial).
    BMC pediatrics, 2018, 08-04, Volume: 18, Issue:1

    Topics: Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Enterocolitis, Necrotiz

2018
The relationship between trough drug concentrations and ductal closure in preterm infants treated with three-dose-oral ibuprofen.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:13

    Topics: Administration, Oral; Birth Weight; Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Fem

2013
Randomised controlled clinical trial of standard versus echocardiographically guided ibuprofen treatment for patent ductus arteriosus in preterm infants: a pilot study.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:9

    Topics: Dose-Response Relationship, Drug; Ductus Arteriosus, Patent; Echocardiography; Female; Gestational A

2014
A Comparison of Early Ibuprofen and Indomethacin Administration to Prevent Intraventricular Hemorrhage Among Preterm Infants.
    Acta medica Iranica, 2016, Volume: 54, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Ductus Arte

2016
Pharmacological closure of patent ductus arteriosus: effects on pulse pressure and on endothelin-1 and vasopressin excretion.
    American journal of perinatology, 2008, Volume: 25, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Blood Pressure; Ductus Arteriosus, Pa

2008
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 2011, Volume: 158, Issue:4

    Topics: Administration, Oral; Bilirubin; Cyclooxygenase Inhibitors; Cystatin C; Ductus Arteriosus, Patent; E

2011
Echocardiography as a guide for patent ductus arteriosus ibuprofen treatment and efficacy prediction.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Drug Administration Schedule; Ductus Arteri

2012
Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2012, Volume: 97, Issue:2

    Topics: Administration, Oral; Birth Weight; Cyclooxygenase Inhibitors; Drug Administration Schedule; Ductus

2012
Unbound bilirubin does not increase during ibuprofen treatment of patent ductus arteriosus in preterm infants.
    The Journal of pediatrics, 2012, Volume: 160, Issue:2

    Topics: Albumins; Bilirubin; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arteriosus,

2012
Treatment of patent ductus arteriosus (PDA) using ibuprofen: renal side-effects in VLBW and ELBW newborns.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:4

    Topics: Birth Weight; Blood Urea Nitrogen; Creatinine; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent;

2013
Ibuprofen prophylaxis in preterm neonates.
    Lancet (London, England), 2002, Aug-10, Volume: 360, Issue:9331

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Hypoxia; Ibup

2002
Oral ibuprofen and indomethacin for treatment of patent ductus arteriosus in premature infants: a randomized trial at Ramathibodi Hospital.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2002, Volume: 85 Suppl 4

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Hu

2002
Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants.
    Pediatrics international : official journal of the Japan Pediatric Society, 2003, Volume: 45, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Femal

2003
A comparison of oral ibuprofen and intravenous indomethacin for closure of patent ductus arteriosus in preterm infants.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2003, Volume: 86 Suppl 3

    Topics: Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofe

2003
Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life.
    Biology of the neonate, 2004, Volume: 86, Issue:3

    Topics: Amikacin; Bacterial Infections; Double-Blind Method; Gestational Age; Half-Life; Humans; Ibuprofen;

2004
Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method.
    Journal of clinical pharmacy and therapeutics, 2005, Volume: 30, Issue:2

    Topics: Bayes Theorem; Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Double-Blind Met

2005
Prophylactic ibuprofen for the prevention of intraventricular hemorrhage among preterm infants: a multicenter, randomized study.
    Pediatrics, 2005, Volume: 115, Issue:6

    Topics: Cerebral Hemorrhage; Cerebral Ventricles; Cerebrovascular Circulation; Double-Blind Method; Ductus A

2005
[Ibuprofen versus indomethacin in the treatment of patent ductus arteriosus in preterm infants].
    Anales de pediatria (Barcelona, Spain : 2003), 2005, Volume: 63, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Indom

2005
Comparison of ibuprofen and indometacin for early-targeted treatment of patent ductus arteriosus in extremely premature infants: a randomised controlled trial.
    Archives of disease in childhood. Fetal and neonatal edition, 2008, Volume: 93, Issue:2

    Topics: Analysis of Variance; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Ductus Arteriosus

2008
Early ibuprofen administration to prevent patent ductus arteriosus in premature newborn infants.
    JAMA, 1996, Feb-21, Volume: 275, Issue:7

    Topics: Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Ductus Arteriosu

1996
Comparative evaluation of the effects of indomethacin and ibuprofen on cerebral perfusion and oxygenation in preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 1997, Volume: 131, Issue:4

    Topics: Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dose-Response Re

1997
Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus.
    The Journal of pediatrics, 1999, Volume: 135, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newbo

1999
A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus.
    The New England journal of medicine, 2000, Sep-07, Volume: 343, Issue:10

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newbo

2000

Other Studies

53 other studies available for ibuprofen and Infant, Premature, Diseases

ArticleYear
Impact of nephrotoxic drugs on urinary biomarkers of renal function in very preterm infants.
    Pediatric research, 2022, Volume: 91, Issue:7

    Topics: Acute Kidney Injury; Amikacin; Biomarkers; Female; Humans; Ibuprofen; Infant; Infant, Newborn; Infan

2022
Management of patent ductus arteriosus in very preterm infants in England and Wales: a retrospective cohort study.
    BMJ paediatrics open, 2022, Volume: 6, Issue:1

    Topics: Ductus Arteriosus, Patent; Female; Fetal Growth Retardation; Humans; Ibuprofen; Indomethacin; Infant

2022
Prophylactic low-dose paracetamol for ductal closure and neurodevelopmental outcome in very preterm infants.
    Acta paediatrica (Oslo, Norway : 1992), 2023, Volume: 112, Issue:8

    Topics: Acetaminophen; Child; Child, Preschool; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant

2023
Increasing the dose of ibuprofen with postnatal age to close a hemodynamically significant patent ductus arteriosus in very preterm infants.
    European journal of pediatrics, 2023, Volume: 182, Issue:8

    Topics: Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Infant, Newborn; Infant, Premature; Infant, Pr

2023
Adverse events related to ibuprofen treatment for patent ductus arteriosus in premature neonates.
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2020, Volume: 27, Issue:8

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; In

2020
The Effect of Dual (Combined) Treatment in Late Preterm Infants with Patent Ductus Arteriosus.
    American journal of perinatology, 2022, Volume: 39, Issue:15

    Topics: Ductus Arteriosus; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant; Infant, Newborn; Infant, Pr

2022
Novel strategy to personalise use of ibuprofen for closure of patent ductus arteriosus in preterm neonates.
    Archives of disease in childhood, 2022, Volume: 107, Issue:1

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Area Under Curve; Drug Monitoring; Du

2022
Using benchmarking to identify inter-centre differences in persistent ductus arteriosus treatment: can we improve outcome?
    Cardiology in the young, 2017, Volume: 27, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Benchmarking; Cardiac Surgical Procedures; Ductus Arteriosu

2017
Reopening of the ductus arteriosus in preterm infants; Clinical aspects and subsequent consequences.
    Journal of neonatal-perinatal medicine, 2018, Volume: 11, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Ductus Arteriosus; Ductus

2018
Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22-27 weeks' gestation.
    Pediatric research, 2019, Volume: 86, Issue:3

    Topics: Biomarkers; Chemokine CCL2; Ductus Arteriosus, Patent; Echocardiography; Growth Differentiation Fact

2019
Does Postmenstrual Age Affect Medical Patent Ductus Arteriosus Treatment Success in Preterm Infants?
    American journal of perinatology, 2019, Volume: 36, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Female; Gestational Age; Humans;

2019
Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus.
    American journal of perinatology, 2019, Volume: 36, Issue:14

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Case-Control Studies; Drug Resistance; Du

2019
Vascular endothelial growth factor polymorphism rs2010963 status does not affect patent ductus arteriosus incidence or cyclooxygenase inhibitor treatment success in preterm infants.
    Cardiology in the young, 2019, Volume: 29, Issue:7

    Topics: Case-Control Studies; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofe

2019
Renal and mesenteric tissue oxygenation in preterm infants treated with oral ibuprofen.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2014, Volume: 27, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Gestational Age; Hemodynamics; H

2014
Risk factors of mild rectal bleeding in very low birth weight infants: a case control study.
    BMC pediatrics, 2013, Nov-27, Volume: 13

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Feces; Female; Gastrointestina

2013
Variation and comparative effectiveness of patent ductus arteriosus pharmacotherapy in extremely low birth weight infants.
    Journal of neonatal-perinatal medicine, 2014, Jan-01, Volume: 7, Issue:3

    Topics: Cohort Studies; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Ibuprofen; Ind

2014
[Clinical characteristics and cardiac hemodynamic changes of patent ductus ateriosus in preterm infants].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2015, Volume: 53, Issue:3

    Topics: Birth Weight; Bronchopulmonary Dysplasia; Cardiac Output; Cyclooxygenase Inhibitors; Ductus Arterios

2015
Neurodevelopmental Outcome at 2 Years of Age according to Patent Ductus Arteriosus Management in Very Preterm Infants.
    Neonatology, 2016, Volume: 109, Issue:2

    Topics: Child, Preschool; Cohort Studies; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibup

2016
Editorial: Patent Ductus Arteriosus in Extremely Premature Neonates.
    Current pediatric reviews, 2016, Volume: 12, Issue:2

    Topics: Anterior Cerebral Artery; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Echocardiography, Do

2016
Oral ibuprofen for patent ductus arteriosus closure in preterm infants: does high osmolality matter?
    American journal of perinatology, 2008, Volume: 25, Issue:5

    Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ib

2008
[First SIBEN clinical consensus: diagnostic and therapeutic approach to patent ductus arteriosus in premature newborns].
    Anales de pediatria (Barcelona, Spain : 2003), 2008, Volume: 69, Issue:5

    Topics: Age Factors; Brain Diseases; Cost-Benefit Analysis; Cyclooxygenase Inhibitors; Diuretics; Ductus Art

2008
Does Ibuprofen increase neonatal hyperbilirubinemia?
    Pediatrics, 2009, Volume: 124, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bilirubin; Cohort Studies; Ductus Arteriosus, Patent; Femal

2009
A second course of ibuprofen is effective in the closure of a clinically significant PDA in ELBW infants.
    Pediatrics, 2009, Volume: 124, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Creatinine; Dose-Response Relationship, Dru

2009
Isoprostane levels in urine of preterm newborns treated with ibuprofen for patent ductus arteriosus closure.
    Pediatric nephrology (Berlin, Germany), 2011, Volume: 26, Issue:1

    Topics: Antioxidants; Ductus Arteriosus, Patent; Female; Free Radicals; Humans; Ibuprofen; Infant, Newborn;

2011
Effect of ibuprofen on bilirubin-albumin binding affinity in premature infants.
    Journal of perinatal medicine, 2011, Volume: 39, Issue:1

    Topics: Albumins; Bilirubin; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Hyperbili

2011
Aminoterminal B-type natriuretic peptide (NT-proBNP) in the therapy of patent ductus arteriosus.
    Minerva pediatrica, 2010, Volume: 62, Issue:3 Suppl 1

    Topics: Biomarkers; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibuprofen; Infant, Extremely

2010
Urinary aquaporin-2 excretion during ibuprofen or indomethacin treatment in preterm infants with patent ductus arteriosus.
    Acta paediatrica (Oslo, Norway : 1992), 2011, Volume: 100, Issue:1

    Topics: Aquaporin 2; Cardiovascular Agents; Ductus Arteriosus, Patent; Female; Gestational Age; Humans; Ibup

2011
Patent ductus arteriosus in the preterm infant: a survey of clinical practices in French neonatal intensive care units.
    Pediatric cardiology, 2011, Volume: 32, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications; Data Collection; Dose-Response Relations

2011
The effects of ibuprofen on sepsis parameters in preterm neonates.
    Early human development, 2012, Volume: 88, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Case-Control Studies; Ductus Arteriosus

2012
Update on management of patent ductus arteriosus in the preterm infant.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2011, Volume: 24 Suppl 3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin;

2011
Ibuprofen lysinate and sodium ibuprofen for prophylaxis of patent ductus arteriosus in preterm neonates.
    Indian pediatrics, 2012, Volume: 49, Issue:1

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Newborn; Infant, Pr

2012
Oral ibuprofen for the treatment of patent ductus arteriosus: further clarification.
    The Journal of pediatrics, 2012, Volume: 160, Issue:1

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infant, Premature, Diseases

2012
Pharmacokinetics of oral ibuprofen for patent ductus arteriosus closure in preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2012, Volume: 97, Issue:1

    Topics: Administration, Oral; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Infan

2012
Failure of a repeat course of cyclooxygenase inhibitor to close a PDA is a risk factor for developing chronic lung disease in ELBW infants.
    BMC pediatrics, 2012, Jan-27, Volume: 12

    Topics: Chronic Disease; Cyclooxygenase Inhibitors; Drug Administration Schedule; Ductus Arteriosus, Patent;

2012
Does treatment of patent ductus arteriosus with cyclooxygenase inhibitors affect neonatal regional tissue oxygenation?
    Pediatric cardiology, 2012, Volume: 33, Issue:8

    Topics: Analysis of Variance; Blood Gas Analysis; Cerebrovascular Circulation; Chi-Square Distribution; Chro

2012
Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates.
    Pediatrics, 2012, Volume: 129, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diseases in Twins; Ductus Arteriosus, Patent; Echocardiogra

2012
Early treatment of the patent ductus arteriosus: do we know what we are doing?.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2012, Volume: 13, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Echocardiography, Doppler, Color

2012
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
An alternative drug (paracetamol) in the management of patent ductus arteriosus in ibuprofen-resistant or contraindicated preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2013, Volume: 98, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Contraindications; Drug Resistance; Ductus Arteriosus, Pate

2013
Pulmonary hypertension in an infant treated with ibuprofen.
    Indian journal of pediatrics, 2013, Volume: 80, Issue:8

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; In

2013
Repeated courses of ibuprofen are effective in closure of a patent ductus arteriosus.
    European journal of pediatrics, 2012, Volume: 171, Issue:11

    Topics: Cyclooxygenase Inhibitors; Drug Administration Schedule; Ductus Arteriosus, Patent; Female; Humans;

2012
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
    American journal of perinatology, 2013, Volume: 30, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema

2013
Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.
    Lancet (London, England), 2002, Sep-28, Volume: 360, Issue:9338

    Topics: Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; Infant, Newborn; Infant, Prem

2002
Safety and efficacy of ibuprofen versus indomethacin in preterm infants.
    European journal of pediatrics, 2003, Volume: 162, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Indomethacin; Infant, Newborn; Infant, P

2003
Urinary ET-1, AVP and sodium in premature infants treated with indomethacin and ibuprofen for patent ductus arteriosus.
    Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arginine Vasopressin; Cyclooxygenase 2 Inhibitors; Ductus A

2005
Consequences of delayed surgical closure of patent ductus arteriosus in very premature infants.
    The Annals of thoracic surgery, 2006, Volume: 81, Issue:1

    Topics: Combined Modality Therapy; Ductus Arteriosus, Patent; Enteral Nutrition; Female; Gestational Age; Hu

2006
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, Jun-20, Volume: 174, Issue:13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Fatal Outcome; Humans; Hypertens

2006
Conservative treatment for patent ductus arteriosus in the preterm.
    Archives of disease in childhood. Fetal and neonatal edition, 2007, Volume: 92, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Femal

2007
Oral ibuprofen in early curative closure of patent ductus arteriosus in very premature infants.
    American journal of perinatology, 2007, Volume: 24, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Echocardiography, Doppler, Color

2007
Ibuprofen treatment of patent ductus arteriosus.
    Lancet (London, England), 1995, Jul-22, Volume: 346, Issue:8969

    Topics: Brain; Cerebrovascular Circulation; Ductus Arteriosus, Patent; Gestational Age; Humans; Ibuprofen; I

1995
Cerebral vasoreactivity to arterial carbon dioxide tension in preterm infants: the effect of ibuprofen.
    The Journal of pediatrics, 1999, Volume: 135, Issue:5

    Topics: Brain; Carbon Dioxide; Cerebrovascular Circulation; Ductus Arteriosus, Patent; Hemoglobins; Humans;

1999
Ibuprofen and patent ductus arteriosus.
    The New England journal of medicine, 2000, Sep-07, Volume: 343, Issue:10

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newbo

2000
Ibuprofen versus indomethacin for closure of patent ductus arteriosus.
    The New England journal of medicine, 2001, Feb-08, Volume: 344, Issue:6

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Ibuprofen; Indomethacin; Infant, Newbo

2001
Ibuprofen-lysine for closure of patent ductus arteriosus.
    Acta paediatrica (Oslo, Norway : 1992), 2001, Volume: 90, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Combinations; Ductus Arteriosus, Patent; Humans; Ibupr

2001