ibuprofen has been researched along with Hypoxia in 34 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia." | 9.69 | Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023) |
| " Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension." | 7.73 | Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006) |
| "The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension." | 7.67 | Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985) |
| "The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia." | 5.69 | Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023) |
| " Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings." | 5.43 | Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016) |
| "Melatonin was administered to another group of mice as a potent ROS scavenger." | 5.37 | Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011) |
| " As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA." | 3.78 | Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. ( Del Rio, R; Iturriaga, R; Madrid, C; Moya, EA; Parga, MJ, 2012) |
| " Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension." | 3.73 | Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006) |
| "The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension." | 3.67 | Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985) |
| "In anesthetized dogs ethchlorvynol (ECV, 9 mg/kg) was selectively administered into the right pulmonary circulation to produce unilateral acute lung injury (ALI) characterized by nonhydrostatic pulmonary edema and systemic hypoxemia." | 3.67 | Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. ( Dahms, TE; Lonigro, AJ; Sprague, RS; Stephenson, AH, 1986) |
| "The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0." | 3.67 | The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction. ( Kim, SD; Marshall, BE; Marshall, C, 1987) |
| " Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings." | 1.43 | Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016) |
| "Ibuprofen blocked the increase in hypoxic ventilation observed in chronically hypoxic rats treated with saline; ibuprofen had no effects on ventilation in normoxic control rats." | 1.37 | Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats. ( Fu, Z; Go, A; Popa, D; Powell, FL, 2011) |
| "Melatonin was administered to another group of mice as a potent ROS scavenger." | 1.37 | Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011) |
| "Rats treated with ibuprofen after transient forebrain ischemia displayed long-lasting protection of CA1 hippocampal neurons." | 1.33 | Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. ( Cho, BP; Cho, S; Cruz, MO; Joh, TH; Park, EM; Volpe, BT, 2005) |
| "The absence of hypoxemia (including a normal alveolar-arterial oxygen difference) in our patient with a massive pulmonary embolus may have been related to cyclooxygenase inhibition due to ibuprofen, with improvement in ventilation-perfusion mismatch." | 1.33 | Massive pulmonary embolus without hypoxemia. ( Baird, JS; Greene, A; Schleien, CL, 2005) |
| "All rabbits were subjected to stepwise cardiac tamponade by inflation of a handmade balloon placed into the pericardial sac to reduce DO2." | 1.32 | Effect of Ibuprofen on interleukin-1beta-induced abnormalities in hemodynamics and oxygen metabolism in rabbits. ( Irisawa, T; Kuwagata, Y; Matsuyama, S; Nakamori, Y; Oda, J; Sugimoto, H; Takahashi, M, 2003) |
| "Ibuprofen treatment (30 mg/kg) had no effect on pial arteriolar diameter during normoxia or hypoxia, and pretreatment did not alter dilation to hypoxia." | 1.30 | Cerebral arteriolar dilation to hypoxia: role of prostanoids. ( Leffler, CW; Parfenova, H, 1997) |
| "Ibuprofen pretreatment did not alter ED50 and slope of dose-response curve, although the absolute value of pressor response in the sevoflurane group with ibuprofen pretreatment was greater than that in the sevoflurane alone group at every concentration of sevoflurane." | 1.29 | Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung. ( Gui, X; Ishibe, Y; Shiokawa, Y; Suekane, K; Umeda, T; Uno, H, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (32.35) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 7 (20.59) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| McKenna, ZJ | 1 |
| Ducharme, JB | 1 |
| Berkemeier, QN | 1 |
| Specht, JW | 1 |
| Fennel, ZJ | 1 |
| Gillum, TL | 1 |
| Deyhle, MR | 1 |
| Amorim, FT | 1 |
| Mermier, CM | 1 |
| Ernst, C | 1 |
| Bek, T | 1 |
| Bavis, RW | 1 |
| Song, MJ | 1 |
| Smachlo, JP | 1 |
| Hulse, A | 1 |
| Kenison, HR | 1 |
| Peralta, JN | 1 |
| Place, JT | 1 |
| Triebwasser, S | 1 |
| Warden, SE | 1 |
| McDonough, AB | 1 |
| De La Zerda, DJ | 1 |
| Stokes, JA | 1 |
| Do, J | 1 |
| Go, A | 2 |
| Fu, Z | 2 |
| Powell, FL | 3 |
| Basaran, KE | 1 |
| Villongco, M | 1 |
| Ho, B | 1 |
| Ellis, E | 1 |
| Zarndt, R | 1 |
| Antonova, J | 1 |
| Hopkins, SR | 1 |
| Gola, S | 2 |
| Gupta, A | 2 |
| Keshri, GK | 2 |
| Nath, M | 1 |
| Velpandian, T | 1 |
| Liu, X | 2 |
| He, L | 2 |
| Stensaas, L | 1 |
| Dinger, B | 2 |
| Fidone, S | 1 |
| Popa, D | 1 |
| Fidone, SJ | 1 |
| Del Rio, R | 2 |
| Moya, EA | 2 |
| Parga, MJ | 1 |
| Madrid, C | 1 |
| Iturriaga, R | 2 |
| Lam, SY | 1 |
| Liu, Y | 1 |
| Ng, KM | 1 |
| Lau, CF | 1 |
| Liong, EC | 1 |
| Tipoe, GL | 1 |
| Fung, ML | 1 |
| Vargas, A | 1 |
| Bustos-Obregón, E | 1 |
| Hartley, R | 1 |
| Schmidt, B | 1 |
| Wright, LL | 1 |
| Davis, P | 1 |
| Solimano, A | 1 |
| Roberts, RS | 1 |
| Palayoor, ST | 1 |
| Tofilon, PJ | 1 |
| Coleman, CN | 1 |
| Kuwagata, Y | 1 |
| Oda, J | 1 |
| Irisawa, T | 1 |
| Matsuyama, S | 1 |
| Nakamori, Y | 1 |
| Takahashi, M | 1 |
| Sugimoto, H | 1 |
| Park, EM | 1 |
| Cho, BP | 1 |
| Volpe, BT | 1 |
| Cruz, MO | 1 |
| Joh, TH | 1 |
| Cho, S | 1 |
| Baird, JS | 1 |
| Greene, A | 1 |
| Schleien, CL | 1 |
| Bellini, C | 1 |
| Campone, F | 1 |
| Serra, G | 1 |
| Perkowski, SZ | 1 |
| Havill, AM | 1 |
| Flynn, JT | 1 |
| Gee, MH | 1 |
| Ishibe, Y | 1 |
| Gui, X | 1 |
| Uno, H | 1 |
| Shiokawa, Y | 1 |
| Umeda, T | 1 |
| Suekane, K | 1 |
| Leffler, CW | 1 |
| Parfenova, H | 1 |
| Coceani, F | 1 |
| Olley, PM | 1 |
| Bishai, I | 1 |
| Bodach, E | 1 |
| Heaton, J | 1 |
| Nashat, M | 1 |
| White, E | 1 |
| Johnson, D | 1 |
| Hurst, T | 1 |
| To, T | 1 |
| Mayers, I | 1 |
| Reeves, WC | 1 |
| Wood, MA | 1 |
| Whitesell, L | 1 |
| Schildt, N | 1 |
| Sprague, RS | 2 |
| Stephenson, AH | 2 |
| Dahms, TE | 2 |
| Lonigro, AJ | 2 |
| Marshall, C | 1 |
| Kim, SD | 1 |
| Marshall, BE | 1 |
| Wagner, EM | 1 |
| Mitzner, WA | 1 |
| Calvin, JE | 1 |
| Dervin, G | 1 |
| Newman, JH | 1 |
| Butka, BJ | 1 |
| Brigham, KL | 1 |
| Mashkovskiĭ, MD | 1 |
| Bobkov, IuG | 1 |
| Shvarts, GIa | 1 |
| Ivanova, IA | 1 |
| Asner, NG | 1 |
| Wenger, H | 1 |
| Wong, C | 1 |
| Demling, RH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253] | Early Phase 1 | 24 participants (Actual) | Interventional | 2020-10-01 | Completed | ||
| Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253] | Phase 3 | 44 participants (Anticipated) | Interventional | 2016-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for ibuprofen and Hypoxia
| Article | Year |
|---|---|
Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia.
Topics: Adult; Chemokine CCL2; Exercise; Gastrointestinal Diseases; Humans; Hypoxia; Ibuprofen; Inflammation | 2023 |
Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans.
Topics: Acclimatization; Adolescent; Adult; Altitude; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; | 2016 |
Ibuprofen prophylaxis in preterm neonates.
Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Hypoxia; Ibup | 2002 |
31 other studies available for ibuprofen and Hypoxia
| Article | Year |
|---|---|
Differential effects of purines and prostaglandins on hypoxia induced dilatation of porcine retinal vessels at different branching level ex vivo.
Topics: Adenosine; Animals; Dilatation; Hypoxia; Ibuprofen; Prostaglandins; Retinal Vessels; Swine | 2023 |
Ventilatory and carotid body responses to acute hypoxia in rats exposed to chronic hypoxia during the first and second postnatal weeks.
Topics: Age Factors; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Femal | 2020 |
Ibuprofen does not reverse ventilatory acclimatization to chronic hypoxia.
Topics: Acclimatization; Analysis of Variance; Animals; Calcium-Binding Proteins; Cyclooxygenase Inhibitors; | 2018 |
Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude.
Topics: Altitude; Animals; Area Under Curve; Cytochrome P-450 CYP2C9; Cytokines; Down-Regulation; Hypoxia; I | 2016 |
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body.
Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Chronic D | 2009 |
Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats.
Topics: Animals; Hypoxia; Ibuprofen; Male; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity.
Topics: Acid Sensing Ion Channels; Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caro | 2011 |
Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular System; Carotid Bod | 2012 |
Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Carotid Artery, | 2012 |
Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin.
Topics: Altitude; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Epididymis; Hematocrit; Hy | 2011 |
Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia.
Topics: Animals; Carotid Body; Hypoxia; Ibuprofen; Inflammation; Interleukin-1beta; Rats; Transcription Fact | 2012 |
Hepatic metabolism of ibuprofen in rats under acute hypobaric hypoxia.
Topics: Acute Disease; Altitude; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 Enzyme S | 2013 |
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tu | 2003 |
Effect of Ibuprofen on interleukin-1beta-induced abnormalities in hemodynamics and oxygen metabolism in rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; | 2003 |
Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain Isc | 2005 |
Massive pulmonary embolus without hypoxemia.
Topics: Adolescent; Cyclooxygenase Inhibitors; Drug Administration Schedule; Humans; Hypoxia; Ibuprofen; Mal | 2005 |
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Fatal Outcome; Humans; Hypertens | 2006 |
Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.
Topics: Animals; Capillary Permeability; Chemotaxis, Leukocyte; Complement Activation; Endothelium; Hyperten | 1983 |
Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung.
Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Ethers; Female; Hypoxia; Ibuprofen; Isoflura | 1993 |
Cerebral arteriolar dilation to hypoxia: role of prostanoids.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Cerebrovascular Circulation; Hy | 1997 |
Prostaglandins and the control of muscle tone in the ductus arteriosus.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Ductus Arteriosus; Gestational Age; Glu | 1977 |
Interactions of endotoxin, prostaglandins, and circulating cells upon pulmonary vascular resistance.
Topics: Animals; Blood Platelets; Dogs; Endotoxins; Granulocytes; Hemodynamics; Hypoxia; Ibuprofen; In Vitro | 1992 |
Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension.
Topics: Animals; Benzazepines; Cardiomegaly; Diltiazem; Hypertension, Pulmonary; Hypoxia; Ibuprofen; Imidazo | 1985 |
Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs.
Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Ethchlorvynol; Hypoxia | 1986 |
The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Arachidonic A | 1987 |
Effect of hypoxia on bronchial circulation.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Bronchi; Bronchial Arteries; Hypoxia; Ibuprofen; Indom | 1988 |
Intravenous ibuprofen blocks the hypoxemia of pulmonary glass bead embolism in the dog.
Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Glass; Hypoxia; Ibuprofen; Oxygen; Partial Pressure; | 1988 |
Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Epoprostenol; Hemodynamics; H | 1986 |
[Experimental study of the antihypoxic properties of ibuprofen and other nonsteroidal anti-inflammatory preparations].
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asphyxia; Drug Evaluation, Preclini | 1987 |
Effects of ibuprofen on the hypoxemia of established ethchlorvynol-induced unilateral acute lung injury in anesthetized dogs.
Topics: Animals; Dogs; Ethchlorvynol; Hemodynamics; Hypoxia; Ibuprofen; Lung Diseases; Male | 1987 |
Pulmonary dysfunction secondary to soft-tissue endotoxin.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Hypoxi | 1985 |