Page last updated: 2024-10-28

ibuprofen and Hypotension

ibuprofen has been researched along with Hypotension in 23 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.

Research Excerpts

ExcerptRelevanceReference
"The arachidonic acid derivative thromboxane A2, a very potent platelet aggregator, is increased in endotoxin shock."7.67Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor. ( Almqvist, PM; Kuenzig, M; Schwartz, SI, 1984)
"The dose response of the nonsteroidal anti-inflammatory drug, ibuprofen, was evaluated in order to determine the most efficacious dose in the treatment of canine endotoxin shock."7.67Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Tryka, AF; Walls, RC, 1988)
"A case of life-threatening hypotension due to sinus arrest is described in a patient in whom exercise-induced hyperkalemia developed during a stable regimen that included verapamil, propranolol, and ibuprofen."7.67Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy. ( Antman, EM; Lee, TH; Rayment, CM; Salomon, DR, 1986)
"Male gender, chorioamnionitis, early sepsis, asphyxia, hemodynamic PDA, persistent hypotension, ibuprofen and paracetamol usage, and orogastric catheter administration were the main risk factors for gastric perforations in VLBW infants."3.88Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature. ( Babayigit, A; Cetinkaya, M; Ozaydın, S; Sander, S, 2018)
"We did not find any complications associated with the use of acetaminophen or ibuprofen in children with enteric fever."3.70Reevaluation of antipyretics in children with enteric fever. ( Fernandez, M; Kaplan, SL; Noyola, DE, 1998)
"The arachidonic acid derivative thromboxane A2, a very potent platelet aggregator, is increased in endotoxin shock."3.67Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor. ( Almqvist, PM; Kuenzig, M; Schwartz, SI, 1984)
"The dose response of the nonsteroidal anti-inflammatory drug, ibuprofen, was evaluated in order to determine the most efficacious dose in the treatment of canine endotoxin shock."3.67Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock. ( Balk, RA; Bone, RC; Jacobs, RF; Tryka, AF; Walls, RC, 1988)
"A case of life-threatening hypotension due to sinus arrest is described in a patient in whom exercise-induced hyperkalemia developed during a stable regimen that included verapamil, propranolol, and ibuprofen."3.67Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy. ( Antman, EM; Lee, TH; Rayment, CM; Salomon, DR, 1986)
"Three young women with systemic lupus erythematosus who were given ibuprofen for arthritis voluntarily discontinued taking the drug."3.66Acute adverse reactions to ibuprofen in systemic lupus erythematosus. ( Finch, WR; Strottman, MP, 1979)
"Treatment with ibuprofen, either before or after ETX, partly restored the elevated levels of nitrite/nitrate."1.33Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock. ( Akbulut, H; Ayar, A; Canbaz, M; Celik, I; Vural, P, 2005)
"Ibuprofen treatment reduced the basal concentrations of all prostanoids to nearly undetectable levels and prevented their changes during hypotension and hypertension."1.28Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets. ( Aranda, JV; Beharry, K; Chatterjee, T; Chemtob, S; Rex, J; Varma, DR, 1991)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199010 (43.48)18.7374
1990's4 (17.39)18.2507
2000's4 (17.39)29.6817
2010's3 (13.04)24.3611
2020's2 (8.70)2.80

Authors

AuthorsStudies
Noori, S1
Seri, I1
Isbister, GK1
Polanski, R1
Cooper, JM1
Keegan, M1
Isoardi, KZ1
Babayigit, A1
Ozaydın, S1
Cetinkaya, M1
Sander, S1
Akingbola, OA1
Singh, D1
Kleinman, JA1
Frieberg, EM1
Dutta, S1
Singh, B1
Chessell, L1
Wilson, J1
Janes, M1
McDonald, K1
Shahid, S1
Gardner, VA1
Hjartarson, A1
Purcha, M1
Watson, J1
de Boer, C1
Gaal, B1
Fusch, C1
Lockwood, JM1
Pricher, MP1
Wilkins, BW1
Holowatz, LA1
Halliwill, JR1
Domoki, F1
Nagy, K1
Temesvári, P1
Bari, F1
Akbulut, H1
Celik, I1
Ayar, A1
Vural, P1
Canbaz, M1
Mou, SS1
Punaro, L1
Antón, J1
Luckett, PM1
Almqvist, PM1
Kuenzig, M1
Schwartz, SI1
Lee, RP1
King, EG1
Russell, AS1
Court, H1
Streete, PJ1
Volans, GN1
Hunt, DP1
Leigh, RJ1
Cimpello, LB1
Craig, S1
Lawrence, E1
Baker, MD1
Noyola, DE1
Fernandez, M1
Kaplan, SL1
Brinkmann, A1
Seeling, W1
Wolf, CF1
Kneitinger, E1
Schönberger, C1
Vogt, N1
Orend, KH1
Büchler, M1
Radermacher, P1
Georgieff, M1
Finch, WR1
Strottman, MP1
Chemtob, S1
Beharry, K1
Rex, J1
Chatterjee, T1
Varma, DR1
Aranda, JV1
Dinarello, CA1
Okusawa, S1
Gelfand, JA1
Balk, RA1
Jacobs, RF1
Tryka, AF1
Walls, RC1
Bone, RC1
Olsen, UB1
Bille-Hansen, V1
Lee, TH1
Salomon, DR1
Rayment, CM1
Antman, EM1
Butterfield, JH1
Schwenk, NM1
Colville, DS1
Kuipers, BJ1

Reviews

1 review available for ibuprofen and Hypotension

ArticleYear
Guidelines for feeding very low birth weight infants.
    Nutrients, 2015, Jan-08, Volume: 7, Issue:1

    Topics: Breast Feeding; Canada; Enema; Enteral Nutrition; Fetal Blood; Food, Fortified; Gastroesophageal Ref

2015

Trials

2 trials available for ibuprofen and Hypotension

ArticleYear
Postexercise hypotension is not explained by a prostaglandin-dependent peripheral vasodilation.
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 98, Issue:2

    Topics: Adult; Blood Pressure; Cyclooxygenase Inhibitors; Humans; Hypotension; Ibuprofen; Leg; Male; Muscle,

2005
Vasopressor hormone response following mesenteric traction during major abdominal surgery.
    Acta anaesthesiologica Scandinavica, 1998, Volume: 42, Issue:8

    Topics: Abdomen; Anesthesia, Epidural; Anesthesia, General; Anti-Inflammatory Agents, Non-Steroidal; Arginin

1998

Other Studies

20 other studies available for ibuprofen and Hypotension

ArticleYear
Hypotension and significant patent ductus arteriosus in infants born extremely preterm during the postnatal transitional period: normal adaptation?
    The Journal of pediatrics, 2022, Volume: 240

    Topics: Adaptation, Physiological; Ductus Arteriosus, Patent; Humans; Hypotension; Ibuprofen; Infant; Infant

2022
Duloxetine overdose causes sympathomimetic and serotonin toxicity without major complications.
    Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:9

    Topics: Acetaminophen; Adult; Antidepressive Agents; Arrhythmias, Cardiac; Coma; Diazepam; Droperidol; Drug

2022
Neonatal gastric perforations in very low birth weight infants: a single center experience and review of the literature.
    Pediatric surgery international, 2018, Volume: 34, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Asphyxia Neonatorum; Chorioamnionitis; Ductus Arteriosus, P

2018
Functional adrenal insufficiency complicating an overdose of naproxen and ibuprofen.
    Clinical pediatrics, 2015, Volume: 54, Issue:1

    Topics: Acidosis; Adolescent; Adrenal Insufficiency; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non

2015
Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.
    Pediatric research, 2005, Volume: 57, Issue:6

    Topics: Acetaminophen; Animals; Animals, Newborn; Arterioles; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxyge

2005
Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock.
    Neuro endocrinology letters, 2005, Volume: 26, Issue:4

    Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Hypotension; Ibuprofen;

2005
Severe systemic hypersensitivity reaction to ibuprofen: a presentation of systemic lupus erythematosus.
    The Journal of rheumatology, 2006, Volume: 33, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Diagnosis, Differential; Drug Hypersensitivity; Huma

2006
Treatment of experimental canine endotoxin shock with ibuprofen, a cyclooxygenase inhibitor.
    Circulatory shock, 1984, Volume: 13, Issue:3

    Topics: Animals; Blood Pressure; Dogs; Female; Hematocrit; Hypotension; Ibuprofen; Leukocyte Count; Lung; Ma

1984
Ibuprofen: a severe systemic reaction.
    Canadian Medical Association journal, 1983, Oct-15, Volume: 129, Issue:8

    Topics: Amoxicillin; Dopamine; Female; Fever; Gingivitis; Humans; Hypotension; Ibuprofen; Middle Aged; Respi

1983
Overdose with ibuprofen causing unconsciousness and hypotension.
    British medical journal (Clinical research ed.), 1981, Mar-28, Volume: 282, Issue:6269

    Topics: Humans; Hypotension; Ibuprofen; Unconsciousness

1981
Overdose with ibuprofen causing unconsciousness and hypotension.
    British medical journal, 1980, Nov-29, Volume: 281, Issue:6253

    Topics: Aged; Humans; Hypotension; Ibuprofen; Male; Unconsciousness

1980
A calcium channel blocker and ibuprofen overdose.
    Current opinion in pediatrics, 1998, Volume: 10, Issue:3

    Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arrhythmias, Cardiac; Calcium Channel Blockers;

1998
Reevaluation of antipyretics in children with enteric fever.
    The Pediatric infectious disease journal, 1998, Volume: 17, Issue:8

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Blood Pressure; Child; Child, Preschool; Female

1998
Acute adverse reactions to ibuprofen in systemic lupus erythematosus.
    JAMA, 1979, Jun-15, Volume: 241, Issue:24

    Topics: Acute Disease; Adult; Arthritis; Drug Hypersensitivity; Female; Fever; Headache; Humans; Hypotension

1979
Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets.
    Investigative ophthalmology & visual science, 1991, Volume: 32, Issue:6

    Topics: Animals; Animals, Newborn; Blood Pressure; Choroid; Homeostasis; Hypertension; Hypotension; Ibuprofe

1991
Interleukin-1 induces a shock-like state in rabbits: synergism with tumor necrosis factor and the effect of ibuprofen.
    Progress in clinical and biological research, 1989, Volume: 299

    Topics: Animals; Drug Synergism; Hypotension; Ibuprofen; Interleukin-1; Rabbits; Recombinant Proteins; Tumor

1989
Low dose ibuprofen reverses the hemodynamic alterations of canine endotoxin shock.
    Critical care medicine, 1988, Volume: 16, Issue:11

    Topics: Animals; Dogs; Dose-Response Relationship, Drug; Escherichia coli; Hemodynamics; Hypotension; Ibupro

1988
Exaggerated hypotension by N-formylmethionylleucyl-phenylalanine in indomethacin pretreated rats. Role of toxic oxygen.
    Agents and actions, 1986, Volume: 17, Issue:5-6

    Topics: Animals; Ascorbic Acid; Blood Pressure; Dimethyl Sulfoxide; Endotoxins; Female; Glucagon; Hypotensio

1986
Hypotension and sinus arrest with exercise-induced hyperkalemia and combined verapamil/propranolol therapy.
    The American journal of medicine, 1986, Volume: 80, Issue:6

    Topics: Drug Interactions; Heart Arrest; Humans; Hypotension; Ibuprofen; Male; Middle Aged; Physical Exertio

1986
Severe generalized reactions to ibuprofen: report of a case.
    The Journal of rheumatology, 1986, Volume: 13, Issue:3

    Topics: Diagnosis, Differential; Disseminated Intravascular Coagulation; Female; Fever; Humans; Hypotension;

1986