Page last updated: 2024-10-28

ibuprofen and Hypertension, Pulmonary

ibuprofen has been researched along with Hypertension, Pulmonary in 30 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.

Research Excerpts

ExcerptRelevanceReference
"Severe pulmonary hypertension may following ibuprofen administration for ductal closure."7.83Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate. ( Aleo, E; Arruza, L; Rodriguez-Castano, MJ, 2016)
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."7.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"The effect of ibuprofen on pulmonary circulation hemodynamics, pulmonary ventilation and blood gaseous metabolism was studied under conditions of cardiac venous catheterization in 8 patients with pulmonary hypertension caused by chronic inflammatory diseases of the lungs."7.67[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension]. ( Gavrisiuk, VK; Iachnik, AI; Morozova, NA; Morskaia, ND, 1989)
"A study of patients with pulmonary hypertension caused by chronic inflammatory pulmonary diseases revealed that ibuprofen may induce an elevation of the pressure in the lesser circulation that is most probably connected with inhibition of synthesis of prostacyclin and prostaglandins of type E."7.67[Vasoconstrictor action of ibuprofen in treating patients with pulmonary hypertension]. ( Diachenko, AP; Draga, NP; Gavrisiuk, VK; Iachnik, AI; Krasnostup, NA, 1989)
"The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension."7.67Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985)
"Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure."5.39Pulmonary hypertension in an infant treated with ibuprofen. ( Kumarshingri, PS; Sehgal, A, 2013)
"Pulmonary hypertension is a rare but potentially fatal complication of ibuprofen administration in preterm infants."5.38Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates. ( Aghai, ZH; Amendolia, B; Bhat, V; Lynn, M; Ritz, SB, 2012)
"Severe pulmonary hypertension may following ibuprofen administration for ductal closure."3.83Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate. ( Aleo, E; Arruza, L; Rodriguez-Castano, MJ, 2016)
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."3.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"In order to investigate whether amniotic fluid could induce the release of mediators from blood cells which would damage the lungs, an isolated perfused rabbit lung (IPRL) was exposed to amniotic fluid embolism-like plasma (AFEP) and the injury of AFEP to lungs and the protective effects of ibuprofen were studied."3.69[Effects of amniotic fluid embolism-like plasma on isolated perfused rabbit lungs]. ( Bahrami, S; Jin, Z; Yu, Y, 1997)
"The effect of ibuprofen on pulmonary circulation hemodynamics, pulmonary ventilation and blood gaseous metabolism was studied under conditions of cardiac venous catheterization in 8 patients with pulmonary hypertension caused by chronic inflammatory diseases of the lungs."3.67[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension]. ( Gavrisiuk, VK; Iachnik, AI; Morozova, NA; Morskaia, ND, 1989)
"A study of patients with pulmonary hypertension caused by chronic inflammatory pulmonary diseases revealed that ibuprofen may induce an elevation of the pressure in the lesser circulation that is most probably connected with inhibition of synthesis of prostacyclin and prostaglandins of type E."3.67[Vasoconstrictor action of ibuprofen in treating patients with pulmonary hypertension]. ( Diachenko, AP; Draga, NP; Gavrisiuk, VK; Iachnik, AI; Krasnostup, NA, 1989)
"The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension."3.67Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985)
"The possible involvement of thromboxane (Tx) in the pulmonary hypertension caused by monocrotaline pyrrole (MCTP) administration to rats was investigated by pharmacological intervention of Tx synthesis and action."3.67Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole. ( Ganey, PE; Roth, RA, 1987)
"Drug therapy for pulmonary hypertension is recommended only for those patients who have irreversible pulmonary hypertension."1.62Comparative Results of Treatment and Complications: Pedea in Open Ductus Arteriosus in Premature Infants. ( Abdrakhmanova, Z; Bekenov, N; Bektenova, G; Datkayeva, G; Gatauova, M; Ilyassova, G; Kemelbekov, K; Khatamov, F; Kuandykov, Y; Musaev, Y; Omarova, B; Tasbulatov, N; Tazhiyeva, A; Tuktibayeva, S; Zhumabekov, Z, 2021)
"Presence of symptomatic patent ductus arteriosus is common in small preterm infants and ibuprofen is commonly used for its medical closure."1.39Pulmonary hypertension in an infant treated with ibuprofen. ( Kumarshingri, PS; Sehgal, A, 2013)
"Pulmonary hypertension is a rare but potentially fatal complication of ibuprofen administration in preterm infants."1.38Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates. ( Aghai, ZH; Amendolia, B; Bhat, V; Lynn, M; Ritz, SB, 2012)
"Pre-treatment with Ibuprofen resulted in complete cardiovascular stability after endotoxin."1.28Right and left ventricular performance during endotoxin-induced pulmonary hypertension in sheep. ( Eliasen, K; Hüttemeier, PC; Jensen, H; Mogensen, T; Nielsen, SL; Ringsted, C, 1989)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199015 (50.00)18.7374
1990's2 (6.67)18.2507
2000's5 (16.67)29.6817
2010's7 (23.33)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Kemelbekov, K1
Musaev, Y1
Bektenova, G1
Datkayeva, G1
Tuktibayeva, S1
Bekenov, N1
Khatamov, F1
Ilyassova, G1
Gatauova, M1
Zhumabekov, Z1
Kuandykov, Y1
Tazhiyeva, A1
Abdrakhmanova, Z1
Omarova, B1
Tasbulatov, N1
Lopez, JI1
Holdridge, A1
Mendizabal, JE1
Bravo, MC1
Cordeiro, M1
Deiros, L1
Pérez-Rodríguez, J1
Rodriguez-Castano, MJ1
Aleo, E1
Arruza, L1
Kim, SY1
Shin, SH1
Kim, HS1
Jung, YH1
Kim, EK1
Choi, JH1
Levy, PT1
El-Khuffash, A1
Amendolia, B1
Lynn, M1
Bhat, V1
Ritz, SB1
Aghai, ZH1
Sehgal, A1
Kumarshingri, PS1
Schmidt, B1
Wright, LL1
Davis, P1
Solimano, A1
Roberts, RS1
Mosca, F1
Bray, M1
Stucchi, I1
Fumagalli, M1
Bellini, C1
Campone, F1
Serra, G1
Perkowski, SZ1
Havill, AM1
Flynn, JT1
Gee, MH1
Hemming, VG1
O'Brien, WF2
Fischer, GW1
Golden, SM1
Noble, SF1
Cefalo, RC1
Lewis, PE1
Fletcher, JR1
Ramwell, PW1
Leeper-Woodford, SK1
Carey, D1
Byrne, K1
Walsh, C1
Fisher, B1
Sugerman, HJ1
Fowler, AA1
Yu, Y1
Jin, Z1
Bahrami, S1
Hey, E1
Gournay, V1
Savagner, C1
Thiriez, G1
Kuster, A1
Rozé, JC1
Demling, RH2
LaLonde, C1
Goad, ME1
Hüttemeier, PC1
Eliasen, K3
Ringsted, C1
Mogensen, T2
Jensen, H1
Nielsen, SL1
Gavrisiuk, VK2
Morozova, NA1
Iachnik, AI2
Morskaia, ND1
Diachenko, AP1
Krasnostup, NA1
Draga, NP1
Reeves, WC1
Wood, MA1
Whitesell, L1
Schildt, N1
Ganey, PE1
Roth, RA1
Ogletree, ML1
Snapper, JR1
Brigham, KL1
Gnidec, AG1
Sibbald, WJ1
Cheung, H1
Metz, CA1
Jensen, NH1
Andersen, JB2
Hasselstrøm, L1
Godtfredsen, J1
Wenger, H1
Wong, C1
Hammond, B1
Fairman, RP1
Monroe, P1
Glauser, FL1
Sugarman, H1
Davis, D1
Hasselstrøm, LJ1

Reviews

1 review available for ibuprofen and Hypertension, Pulmonary

ArticleYear
Altitude headache.
    Current pain and headache reports, 2013, Volume: 17, Issue:12

    Topics: Acute Disease; Adaptation, Physiological; Altitude; Altitude Sickness; Anti-Inflammatory Agents; Asp

2013

Trials

2 trials available for ibuprofen and Hypertension, Pulmonary

ArticleYear
Ibuprofen prophylaxis in preterm neonates.
    Lancet (London, England), 2002, Aug-10, Volume: 360, Issue:9331

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Hypoxia; Ibup

2002
Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.
    Lancet (London, England), 2002, Apr-27, Volume: 359, Issue:9316

    Topics: Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Electrocardiography; Humans; Hypertension, Pulm

2002

Other Studies

27 other studies available for ibuprofen and Hypertension, Pulmonary

ArticleYear
Comparative Results of Treatment and Complications: Pedea in Open Ductus Arteriosus in Premature Infants.
    Journal of cardiovascular pharmacology, 2021, 11-01, Volume: 78, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Cardiac Surgical Procedures; Clini

2021
Lethal pulmonary hypertension associated with ibuprofen treatment in a very low birth weight infant.
    Journal of paediatrics and child health, 2014, Volume: 50, Issue:1

    Topics: Ductus Arteriosus, Patent; Fatal Outcome; Humans; Hypertension, Pulmonary; Ibuprofen; Infant, Extrem

2014
Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate.
    Indian pediatrics, 2016, Volume: 53, Issue:4

    Topics: Humans; Hypertension, Pulmonary; Ibuprofen; Infant, Newborn; Male; Sildenafil Citrate; Vasodilator A

2016
Pulmonary Arterial Hypertension after Ibuprofen Treatment for Patent Ductus Arteriosus in Very Low Birth Weight Infants.
    The Journal of pediatrics, 2016, Volume: 179

    Topics: Cohort Studies; Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Female; Humans; Hypertension,

2016
Pulmonary arterial hypertension after ibuprofen treatment in the first week of life?
    The Journal of pediatrics, 2017, Volume: 182

    Topics: Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; Infant, Premature

2017
Severe pulmonary hypertension with therapeutic L-lysine ibuprofen in 2 preterm neonates.
    Pediatrics, 2012, Volume: 129, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diseases in Twins; Ductus Arteriosus, Patent; Echocardiogra

2012
Pulmonary hypertension in an infant treated with ibuprofen.
    Indian journal of pediatrics, 2013, Volume: 80, Issue:8

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; In

2013
Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants.
    Lancet (London, England), 2002, Sep-28, Volume: 360, Issue:9338

    Topics: Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; Infant, Newborn; Infant, Prem

2002
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, Jun-20, Volume: 174, Issue:13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Fatal Outcome; Humans; Hypertens

2006
Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.
    Circulation research, 1983, Volume: 53, Issue:5

    Topics: Animals; Capillary Permeability; Chemotaxis, Leukocyte; Complement Activation; Endothelium; Hyperten

1983
Studies of short-term pulmonary and peripheral vascular responses induced in oophorectomized sheep by the infusion of a group B streptococcal extract.
    Pediatric research, 1984, Volume: 18, Issue:3

    Topics: Animals; Blood Pressure; Castration; Endotoxins; Escherichia coli; Female; Femoral Artery; Hypertens

1984
The role of prostaglandins in endotoxemia: comparisons in response in the nonpregnant, maternal, and fetal models. I. Prostaglandins and the pulmonary effect of experimental endotoxemia.
    American journal of obstetrics and gynecology, 1980, May-01, Volume: 137, Issue:1

    Topics: Animals; Castration; Endotoxins; Escherichia coli; Female; Hypertension, Pulmonary; Ibuprofen; Indom

1980
Histamine receptor antagonists, cyclooxygenase blockade, and tumor necrosis factor during acute septic insult.
    Shock (Augusta, Ga.), 1998, Volume: 9, Issue:2

    Topics: Animals; Bacteremia; Blood Pressure; Cardiac Output; Cimetidine; Cyclooxygenase Inhibitors; Diphenhy

1998
[Effects of amniotic fluid embolism-like plasma on isolated perfused rabbit lungs].
    Zhonghua fu chan ke za zhi, 1997, Volume: 32, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Embolism, Amniotic Fluid; Female;

1997
Clinical trials: when to start and when to stop.
    Lancet (London, England), 2002, Apr-27, Volume: 359, Issue:9316

    Topics: Analgesics, Non-Narcotic; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Ibuprofen; Inf

2002
Effect of ibuprofen on the pulmonary and systemic response to repeated doses of endotoxin.
    Surgery, 1989, Volume: 105, Issue:3

    Topics: Animals; Blood Pressure; Body Temperature; Cardiac Output; Endotoxins; Escherichia coli; Hypertensio

1989
Right and left ventricular performance during endotoxin-induced pulmonary hypertension in sheep.
    Clinical physiology (Oxford, England), 1989, Volume: 9, Issue:1

    Topics: Animals; Endotoxins; Escherichia coli; Hemodynamics; Hypertension, Pulmonary; Ibuprofen; Sheep; Stro

1989
[The effect of ibuprofen on the hemodynamics of the lesser circulation in patients with pulmonary hypertension].
    Problemy tuberkuleza, 1989, Issue:1

    Topics: Adult; Female; Hemodynamics; Humans; Hypertension, Pulmonary; Ibuprofen; Male; Middle Aged; Pulmonar

1989
[Vasoconstrictor action of ibuprofen in treating patients with pulmonary hypertension].
    Vrachebnoe delo, 1989, Issue:1

    Topics: Adult; Cardiac Catheterization; Drug Evaluation; Female; Humans; Hypertension, Pulmonary; Ibuprofen;

1989
Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension.
    The American journal of cardiology, 1985, Sep-01, Volume: 56, Issue:7

    Topics: Animals; Benzazepines; Cardiomegaly; Diltiazem; Hypertension, Pulmonary; Hypoxia; Ibuprofen; Imidazo

1985
Thromboxane does not mediate pulmonary vascular response to monocrotaline pyrrole.
    The American journal of physiology, 1987, Volume: 252, Issue:4 Pt 2

    Topics: Animals; Cyclooxygenase Inhibitors; Dibenzothiepins; Hypertension, Pulmonary; Ibuprofen; Imidazoles;

1987
Direct and indirect effects of leukotriene D4 on the lungs of unanesthetized sheep.
    Respiration; international review of thoracic diseases, 1987, Volume: 51, Issue:4

    Topics: 6-Ketoprostaglandin F1 alpha; Anesthesia; Animals; Arachidonate 5-Lipoxygenase; Blood Pressure; Fema

1987
Ibuprofen reduces the progression of permeability edema in an animal model of hyperdynamic sepsis.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:3

    Topics: Animals; Bacterial Infections; Disease Models, Animal; Hemodynamics; Hypertension, Pulmonary; Ibupro

1988
[Acute pulmonary hypertension treated with ibuprofen].
    Ugeskrift for laeger, 1986, Sep-29, Volume: 148, Issue:40

    Topics: Acute Disease; Aged; Humans; Hypertension, Pulmonary; Ibuprofen; Male; Pulmonary Embolism

1986
Pulmonary dysfunction secondary to soft-tissue endotoxin.
    Archives of surgery (Chicago, Ill. : 1960), 1985, Volume: 120, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Hypoxi

1985
The pulmonary hypertension of sclerosing agents is prevented by cyclooxygenase inhibitors.
    The American journal of the medical sciences, 1985, Volume: 290, Issue:3

    Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Drug Combinations; Female; Hypertension, Pulmona

1985
Lowering pulmonary artery pressure in a patient with severe acute respiratory failure.
    Intensive care medicine, 1985, Volume: 11, Issue:1

    Topics: Blood Pressure; Humans; Hypertension, Pulmonary; Ibuprofen; Male; Middle Aged; Myocardial Infarction

1985