Page last updated: 2024-10-28

ibuprofen and Headache, Tension

ibuprofen has been researched along with Headache, Tension in 19 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
" Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache."9.12Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007)
"Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache."9.09The use of ibuprofen plus caffeine to treat tension-type headache. ( Diamond, S; Freitag, FG, 2001)
"The safety and efficacy of treatment of tension-type headache with either ketoprofen or ibuprofen and naproxen sodium were evaluated in a prospective, randomized, double-blind parallel-group-study in 345 subjects."9.08Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. ( Lange, R; Lentz, R, 1995)
"Ibuprofen 400 mg provides an important benefit in terms of being pain free at 2 hours for a small number of people with frequent episodic tension-type headache who have an acute headache with moderate or severe initial pain."8.91Ibuprofen for acute treatment of episodic tension-type headache in adults. ( Bendtsen, L; Derry, S; Moore, RA; Wiffen, PJ, 2015)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."7.73Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
"Ibuprofen was associated with a lower likelihood of the occurrence of any events and gastrointestinal adverse events compared with placebo and paracetamol (OR: 0."7.01Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis. ( Albunaian, N; Alfehaid, M; Alhamoud, M; Alhumrran, H; Alnasser, A; Ferwana, M, 2023)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."6.55Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
" Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache."5.12Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007)
"Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache."5.09The use of ibuprofen plus caffeine to treat tension-type headache. ( Diamond, S; Freitag, FG, 2001)
"The safety and efficacy of treatment of tension-type headache with either ketoprofen or ibuprofen and naproxen sodium were evaluated in a prospective, randomized, double-blind parallel-group-study in 345 subjects."5.08Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. ( Lange, R; Lentz, R, 1995)
"Ibuprofen 400 mg provides an important benefit in terms of being pain free at 2 hours for a small number of people with frequent episodic tension-type headache who have an acute headache with moderate or severe initial pain."4.91Ibuprofen for acute treatment of episodic tension-type headache in adults. ( Bendtsen, L; Derry, S; Moore, RA; Wiffen, PJ, 2015)
"Though all non-narcotic analgesics have equivalent efficacy against tension-type headache, ibuprofen's generally favorable side-effect profile makes it a reasonable first choice."4.83Is any one analgesic superior for episodic tension-type headache? ( Berger, MY; Damen, L; Koes, BW; Merlijn, V; Passchier, J; Verhagen, AP, 2006)
" For the acute treatment of migraine attacks or tension-type headache, ibuprofen (10 mg per kg body weight) or acetaminophen (15 mg per kg body weight) are recommended with highest evidence, intranasal sumatriptan (10 to 20 mg) can be given as second choice."4.81[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. ( Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M, 2002)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."3.73Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
"Ibuprofen was associated with a lower likelihood of the occurrence of any events and gastrointestinal adverse events compared with placebo and paracetamol (OR: 0."3.01Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis. ( Albunaian, N; Alfehaid, M; Alhamoud, M; Alhumrran, H; Alnasser, A; Ferwana, M, 2023)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."2.55Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
" The fixed dose combination of ibuprofen and paracetamol significantly increases the rate of absorption of paracetamol, which has potential therapeutic benefits in terms of a faster analgesias onset."1.62[Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief]. ( Khaytovich, ED; Perkov, AV; Shikh, EV, 2021)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's9 (47.37)29.6817
2010's6 (31.58)24.3611
2020's2 (10.53)2.80

Authors

AuthorsStudies
Shikh, EV1
Khaytovich, ED1
Perkov, AV1
Alnasser, A1
Alhumrran, H1
Alfehaid, M1
Alhamoud, M1
Albunaian, N1
Ferwana, M1
Lipton, RB1
Diener, HC1
Robbins, MS1
Garas, SY1
Patel, K1
Duma, SN1
Derry, S1
Wiffen, PJ1
Moore, RA1
Bendtsen, L2
Beran, RG1
Yancey, J1
Saas, P1
Manzano, S1
Doyon-Trottier, E1
Bailey, B1
Kubitzek, F1
Ziegler, G1
Gold, MS1
Liu, JM1
Ionescu, E1
Palungwachira, P2
Ogawa, H1
Verhagen, AP1
Damen, L1
Berger, MY1
Passchier, J1
Merlijn, V1
Koes, BW1
Haag, G1
Buchgreitz, L1
Ashina, S1
Jensen, R1
Lange, R1
Lentz, R1
Schachtel, BP1
Furey, SA1
Thoden, WR1
Diamond, S2
Balm, TK1
Freitag, FG2
Sparano, N1
Evers, S1
Pothmann, R1
Uberall, M1
Naumann, E1
Gerber, WD1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]Phase 462 participants (Actual)Interventional2020-02-10Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of Headache Free Period at 7 Days

(NCT03951649)
Timeframe: 7 days

Interventiondays (Median)
Occipital Nerve Block6
Oral Acetaminophen/Caffeine Group1

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

(NCT03951649)
Timeframe: 28 days

InterventionParticipants (Count of Participants)
Occipital Nerve Block9
Oral Acetaminophen/Caffeine Group4

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

(NCT03951649)
Timeframe: 7 days

InterventionParticipants (Count of Participants)
Occipital Nerve Block7
Oral Acetaminophen/Caffeine Group2

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Other: Pain at injection site (NCT03951649)
Timeframe: 7 days

InterventionParticipants (Count of Participants)
Occipital Nerve Block0
Oral Acetaminophen/Caffeine Group2

Number of Participants With Need for Admission for Treatment of Headache

(NCT03951649)
Timeframe: 7 hours

InterventionParticipants (Count of Participants)
Occipital Nerve Block0
Oral Acetaminophen/Caffeine Group0

Number of Participants With Need for Crossover Treatment

(NCT03951649)
Timeframe: 4 hours

InterventionParticipants (Count of Participants)
Occipital Nerve Block9
Oral Acetaminophen/Caffeine Group14

Number of Participants With Need for Neurology Consult

(NCT03951649)
Timeframe: 5 hours

InterventionParticipants (Count of Participants)
Occipital Nerve Block4
Oral Acetaminophen/Caffeine Group2

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

InterventionParticipants (Count of Participants)
Occipital Nerve Block5
Oral Acetaminophen/Caffeine Group1

Number of Participants With Need for Second Line Treatment

(NCT03951649)
Timeframe: 120 min

InterventionParticipants (Count of Participants)
Occipital Nerve Block5
Oral Acetaminophen/Caffeine Group5

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

InterventionParticipants (Count of Participants)
Occipital Nerve Block20
Oral Acetaminophen/Caffeine Group16

Response to Cross Over Treatment at 60 Min

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Interventionscore on a scale (Median)
Occipital Nerve Block6
Oral Acetaminophen/Caffeine Group3

Response to Second Line Treatment at 60 Min

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 180min

Interventionscore on a scale (Median)
Occipital Nerve Block6
Oral Acetaminophen/Caffeine Group4

Response to Treatment Within 2 Hours

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 2 hrs

Interventionscore on a scale (Median)
Occipital Nerve Block6.0
Oral Acetaminophen/Caffeine Group6.5

Reviews

8 reviews available for ibuprofen and Headache, Tension

ArticleYear
Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis.
    Scientific reports, 2023, Dec-06, Volume: 13, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Ibuprofen; Network Meta-Analysis; Tension-Type Head

2023
Caffeine in the management of patients with headache.
    The journal of headache and pain, 2017, Oct-24, Volume: 18, Issue:1

    Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan

2017
Ibuprofen for acute treatment of episodic tension-type headache in adults.
    The Cochrane database of systematic reviews, 2015, Jul-31, Issue:7

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Dic

2015
Ibuprofen for Treatment of Episodic Tension-Type Headaches.
    American family physician, 2016, May-01, Volume: 93, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Tension-Type Headache

2016
Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults.
    CJEM, 2010, Volume: 12, Issue:3

    Topics: Acetaminophen; Adolescent; Adult; Altitude Sickness; Analgesics, Non-Narcotic; Child; Headache; Huma

2010
Is any one analgesic superior for episodic tension-type headache?
    The Journal of family practice, 2006, Volume: 55, Issue:12

    Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Dos

2006
[Self-medication of migraine and headache].
    MMW Fortschritte der Medizin, 2006, Nov-23, Volume: 148, Issue:47

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;

2006
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)].
    Schmerz (Berlin, Germany), 2002, Volume: 16, Issue:1

    Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psyc

2002

Trials

7 trials available for ibuprofen and Headache, Tension

ArticleYear
[A role of treatment of autonomic syndrome in patients with tension-type headache].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:2

    Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Autonomic Nervous System; Autonomic Nervous S

2015
Low-dose diclofenac potassium in the treatment of episodic tension-type headache.
    European journal of pain (London, England), 2003, Volume: 7, Issue:2

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Double

2003
Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache.
    European journal of neurology, 2007, Volume: 14, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-

2007
Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache.
    Drugs under experimental and clinical research, 1995, Volume: 21, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Human

1995
Nonprescription ibuprofen and acetaminophen in the treatment of tension-type headache.
    Journal of clinical pharmacology, 1996, Volume: 36, Issue:12

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Male

1996
Ibuprofen plus caffeine in the treatment of tension-type headache.
    Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:3

    Topics: Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimul

2000
The use of ibuprofen plus caffeine to treat tension-type headache.
    Current pain and headache reports, 2001, Volume: 5, Issue:5

    Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Doub

2001

Other Studies

4 other studies available for ibuprofen and Headache, Tension

ArticleYear
[Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief].
    Terapevticheskii arkhiv, 2021, Aug-15, Volume: 93, Issue:8

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Drug Combinations; Humans; Ibuprofen; Tension-T

2021
Ibuprofen for the treatment of TTH.
    Evidence-based medicine, 2016, Volume: 21, Issue:2

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Humans; Ibuprofen; Tension-Type Headache; Treatment

2016
Localized periorbital edema induced by Ibuprofen.
    The Journal of dermatology, 2005, Volume: 32, Issue:12

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Follow-Up Stud

2005
Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache?
    The Journal of family practice, 2001, Volume: 50, Issue:1

    Topics: Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Drug The

2001