ibuprofen and Headache, Tension studies

Research Excerpts

Excerpt	Relevance	Reference
" Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache."	9.12	Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007)
"Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache."	9.09	The use of ibuprofen plus caffeine to treat tension-type headache. ( Diamond, S; Freitag, FG, 2001)
"The safety and efficacy of treatment of tension-type headache with either ketoprofen or ibuprofen and naproxen sodium were evaluated in a prospective, randomized, double-blind parallel-group-study in 345 subjects."	9.08	Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. ( Lange, R; Lentz, R, 1995)
"Ibuprofen 400 mg provides an important benefit in terms of being pain free at 2 hours for a small number of people with frequent episodic tension-type headache who have an acute headache with moderate or severe initial pain."	8.91	Ibuprofen for acute treatment of episodic tension-type headache in adults. ( Bendtsen, L; Derry, S; Moore, RA; Wiffen, PJ, 2015)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."	7.73	Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
"Ibuprofen was associated with a lower likelihood of the occurrence of any events and gastrointestinal adverse events compared with placebo and paracetamol (OR: 0."	7.01	Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis. ( Albunaian, N; Alfehaid, M; Alhamoud, M; Alhumrran, H; Alnasser, A; Ferwana, M, 2023)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	6.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
" Mirtazapine has a prophylactic and ibuprofen an acute effect in tension-type headache."	5.12	Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. ( Ashina, S; Bendtsen, L; Buchgreitz, L; Jensen, R, 2007)
"Simple analgesics such as ibuprofen, aspirin, and acetaminophen have long been used in the treatment of tension-type headache."	5.09	The use of ibuprofen plus caffeine to treat tension-type headache. ( Diamond, S; Freitag, FG, 2001)
"The safety and efficacy of treatment of tension-type headache with either ketoprofen or ibuprofen and naproxen sodium were evaluated in a prospective, randomized, double-blind parallel-group-study in 345 subjects."	5.08	Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. ( Lange, R; Lentz, R, 1995)
"Ibuprofen 400 mg provides an important benefit in terms of being pain free at 2 hours for a small number of people with frequent episodic tension-type headache who have an acute headache with moderate or severe initial pain."	4.91	Ibuprofen for acute treatment of episodic tension-type headache in adults. ( Bendtsen, L; Derry, S; Moore, RA; Wiffen, PJ, 2015)
"Though all non-narcotic analgesics have equivalent efficacy against tension-type headache, ibuprofen's generally favorable side-effect profile makes it a reasonable first choice."	4.83	Is any one analgesic superior for episodic tension-type headache? ( Berger, MY; Damen, L; Koes, BW; Merlijn, V; Passchier, J; Verhagen, AP, 2006)
" For the acute treatment of migraine attacks or tension-type headache, ibuprofen (10 mg per kg body weight) or acetaminophen (15 mg per kg body weight) are recommended with highest evidence, intranasal sumatriptan (10 to 20 mg) can be given as second choice."	4.81	[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. ( Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M, 2002)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."	3.73	Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
"Ibuprofen was associated with a lower likelihood of the occurrence of any events and gastrointestinal adverse events compared with placebo and paracetamol (OR: 0."	3.01	Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis. ( Albunaian, N; Alfehaid, M; Alhamoud, M; Alhumrran, H; Alnasser, A; Ferwana, M, 2023)
" Additional studies are needed to assess the relationship between caffeine dosing and clinical benefits in patients with TTH and migraine."	2.55	Caffeine in the management of patients with headache. ( Diener, HC; Garas, SY; Lipton, RB; Patel, K; Robbins, MS, 2017)
" The fixed dose combination of ibuprofen and paracetamol significantly increases the rate of absorption of paracetamol, which has potential therapeutic benefits in terms of a faster analgesias onset."	1.62	[Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief]. ( Khaytovich, ED; Perkov, AV; Shikh, EV, 2021)

Research

Studies (19)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Duration of Headache Free Period at 7 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 28 Days

Number of Participants With Development of Hypertensive Disease of Pregnancy Within 7 Days

Number of Participants With Injection Site Complication (Infection, Hematoma, and Ecchymosis)

Number of Participants With Need for Admission for Treatment of Headache

Number of Participants With Need for Crossover Treatment

Number of Participants With Need for Neurology Consult

Number of Participants With Need for Representation for Treatment of Headache With 28 Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (10.53)	18.2507
2000's	9 (47.37)	29.6817
2010's	6 (31.58)	24.3611
2020's	2 (10.53)	2.80

Authors	Studies
Shikh, EV	1
Khaytovich, ED	1
Perkov, AV	1
Alnasser, A	1
Alhumrran, H	1
Alfehaid, M	1
Alhamoud, M	1
Albunaian, N	1
Ferwana, M	1
Lipton, RB	1
Diener, HC	1
Robbins, MS	1
Garas, SY	1
Patel, K	1
Duma, SN	1
Derry, S	1
Wiffen, PJ	1
Moore, RA	1
Bendtsen, L	2
Beran, RG	1
Yancey, J	1
Saas, P	1
Manzano, S	1
Doyon-Trottier, E	1
Bailey, B	1
Kubitzek, F	1
Ziegler, G	1
Gold, MS	1
Liu, JM	1
Ionescu, E	1
Palungwachira, P	2
Ogawa, H	1
Verhagen, AP	1
Damen, L	1
Berger, MY	1
Passchier, J	1
Merlijn, V	1
Koes, BW	1
Haag, G	1
Buchgreitz, L	1
Ashina, S	1
Jensen, R	1
Lange, R	1
Lentz, R	1
Schachtel, BP	1
Furey, SA	1
Thoden, WR	1
Diamond, S	2
Balm, TK	1
Freitag, FG	2
Sparano, N	1
Evers, S	1
Pothmann, R	1
Uberall, M	1
Naumann, E	1
Gerber, WD	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Acute Headache Treatment in Pregnancy: Improvement in Pain Scores With Occipital Nerve Block vs PO Acetaminophen With Caffeine A Randomized Controlled Trial[NCT03951649]	Phase 4	62 participants (Actual)	Interventional	2020-02-10	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	days (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	4

Intervention	Participants (Count of Participants)
Occipital Nerve Block	7
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	2

Intervention	Participants (Count of Participants)
Occipital Nerve Block	0
Oral Acetaminophen/Caffeine Group	0

Intervention	Participants (Count of Participants)
Occipital Nerve Block	9
Oral Acetaminophen/Caffeine Group	14

Intervention	Participants (Count of Participants)
Occipital Nerve Block	4
Oral Acetaminophen/Caffeine Group	2

Emergency department for treatment of headache since treatment asked at 28 day follow up (NCT03951649)
Timeframe: 28 days

Number of Participants With Need for Second Line Treatment

Number of Participants With Response to Occipital Nerve Block in Pregnancy

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	1

Intervention	Participants (Count of Participants)
Occipital Nerve Block	5
Oral Acetaminophen/Caffeine Group	5

Based on guidelines from the International Headache Society the primary outcome is the portion of women who experience resolution of headache or improvement of headache to mild range (VRS ≤ 3) at 2 hours following treatment with Occipital nerve block as compared to acetaminophen/caffeine cocktail. (NCT03951649)
Timeframe: 60-300 min

Response to Cross Over Treatment at 60 Min

Intervention	Participants (Count of Participants)
Occipital Nerve Block	20
Oral Acetaminophen/Caffeine Group	16

"Visual/verbal Rating Score (VRS). VRS is used to assess pain in patients. With 0 representing no pain at all and 10 representing worst possible pain.~Total Minimum score=0 Total Maximum score=10~Higher values represent worse pain. If VRS=0, then the headache pain is considered resolved." (NCT03951649)
Timeframe: 60 min

Response to Second Line Treatment at 60 Min

Intervention	score on a scale (Median)
Occipital Nerve Block	6
Oral Acetaminophen/Caffeine Group	3

Response to Treatment Within 2 Hours

Article	Year
Paracetamol versus ibuprofen in treating episodic tension-type headache: a systematic review and network meta-analysis. Scientific reports, 2023, Dec-06, Volume: 13, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Ibuprofen; Network Meta-Analysis; Tension-Type Head	2023
Caffeine in the management of patients with headache. The journal of headache and pain, 2017, Oct-24, Volume: 18, Issue:1 Topics: Abdominal Pain; Acetaminophen; Adult; Analgesics; Aspirin; Caffeine; Central Nervous System Stimulan	2017
Ibuprofen for acute treatment of episodic tension-type headache in adults. The Cochrane database of systematic reviews, 2015, Jul-31, Issue:7 Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Dic	2015
Ibuprofen for Treatment of Episodic Tension-Type Headaches. American family physician, 2016, May-01, Volume: 93, Issue:9 Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Ibuprofen; Tension-Type Headache	2016
Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults. CJEM, 2010, Volume: 12, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Altitude Sickness; Analgesics, Non-Narcotic; Child; Headache; Huma	2010
Is any one analgesic superior for episodic tension-type headache? The Journal of family practice, 2006, Volume: 55, Issue:12 Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Diclofenac; Dos	2006
[Self-medication of migraine and headache]. MMW Fortschritte der Medizin, 2006, Nov-23, Volume: 148, Issue:47 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Caffeine;	2006
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. Schmerz (Berlin, Germany), 2002, Volume: 16, Issue:1 Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psyc	2002

Article	Year
[A role of treatment of autonomic syndrome in patients with tension-type headache]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:2 Topics: Administration, Oral; Adult; Analgesics, Non-Narcotic; Autonomic Nervous System; Autonomic Nervous S	2015
Low-dose diclofenac potassium in the treatment of episodic tension-type headache. European journal of pain (London, England), 2003, Volume: 7, Issue:2 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dose-Response Relationship, Drug; Double	2003
Combination of low-dose mirtazapine and ibuprofen for prophylaxis of chronic tension-type headache. European journal of neurology, 2007, Volume: 14, Issue:2 Topics: Adrenergic alpha-Antagonists; Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Dose-	2007
Comparison ketoprofen, ibuprofen and naproxen sodium in the treatment of tension-type headache. Drugs under experimental and clinical research, 1995, Volume: 21, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Human	1995
Nonprescription ibuprofen and acetaminophen in the treatment of tension-type headache. Journal of clinical pharmacology, 1996, Volume: 36, Issue:12 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Ibuprofen; Male	1996
Ibuprofen plus caffeine in the treatment of tension-type headache. Clinical pharmacology and therapeutics, 2000, Volume: 68, Issue:3 Topics: Administration, Oral; Adult; Aged; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimul	2000
The use of ibuprofen plus caffeine to treat tension-type headache. Current pain and headache reports, 2001, Volume: 5, Issue:5 Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Doub	2001

Article	Year
[Clinical and pharmacological approaches to the choice of a drug for a tension-type headache relief]. Terapevticheskii arkhiv, 2021, Aug-15, Volume: 93, Issue:8 Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Drug Combinations; Humans; Ibuprofen; Tension-T	2021
Ibuprofen for the treatment of TTH. Evidence-based medicine, 2016, Volume: 21, Issue:2 Topics: Administration, Oral; Analgesics, Non-Narcotic; Humans; Ibuprofen; Tension-Type Headache; Treatment	2016
Localized periorbital edema induced by Ibuprofen. The Journal of dermatology, 2005, Volume: 32, Issue:12 Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Follow-Up Stud	2005
Is the combination of ibuprofen and caffeine effective for the treatment of a tension-type headache? The Journal of family practice, 2001, Volume: 50, Issue:1 Topics: Analgesics, Non-Narcotic; Caffeine; Central Nervous System Stimulants; Double-Blind Method; Drug The	2001

ibuprofen and Headache, Tension