Page last updated: 2024-10-28
ibuprofen and Glioma
ibuprofen has been researched along with Glioma in 13 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model." | 9.16 | Effects of Ibuprofen on orthotopic glioma model in rats. ( Bilir, A; Bozkurt, ER; Dagêstan, Y; Karaca, I, 2012) |
| " For glioma, research has generally focused on diclofenac; however data on other NSAIDs, such as ibuprofen, is limited." | 7.81 | Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. ( Bogdahn, U; Grauer, OM; Hau, P; Jachnik, B; Kreutz, M; Leidgens, V; Leukel, P; Seliger, C; Vollmann-Zwerenz, A; Welz, T, 2015) |
| "The Diruthenium-Ibuprofen compound [Ru2Cl(Ibp)4] (or RuIbp) is known to cause significant inhibition of C6 rat glioma cell proliferation in vitro." | 7.80 | Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo. ( Benadiba, M; Colquhoun, A; de M Costa, I; de Oliveira Silva, D; Santos, RL; Serachi, FO, 2014) |
| "The metabolism of anandamide by fatty acid amidohydrolase (FAAH) at different intra- and extracellular pH values has been investigated in intact C6 rat glioma cells." | 7.72 | Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. ( Fowler, CJ; Holt, S, 2003) |
| " We have studied two liposoluble drugs, MPA and the analgesic ibuprofen, on glioma vascularization in vivo." | 7.71 | Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain. ( Altinoz, MA; Altug, T; Aydiner, A; Bilir, A; Bozcali, E; Ozar, E; Sav, A; Taskin, M, 2001) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 7.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats." | 7.67 | Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model. ( Del Maestro, RF; Farrell, CL; Megyesi, J, 1988) |
| "To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model." | 5.16 | Effects of Ibuprofen on orthotopic glioma model in rats. ( Bilir, A; Bozkurt, ER; Dagêstan, Y; Karaca, I, 2012) |
| " For glioma, research has generally focused on diclofenac; however data on other NSAIDs, such as ibuprofen, is limited." | 3.81 | Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. ( Bogdahn, U; Grauer, OM; Hau, P; Jachnik, B; Kreutz, M; Leidgens, V; Leukel, P; Seliger, C; Vollmann-Zwerenz, A; Welz, T, 2015) |
| "The Diruthenium-Ibuprofen compound [Ru2Cl(Ibp)4] (or RuIbp) is known to cause significant inhibition of C6 rat glioma cell proliferation in vitro." | 3.80 | Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo. ( Benadiba, M; Colquhoun, A; de M Costa, I; de Oliveira Silva, D; Santos, RL; Serachi, FO, 2014) |
| "The metabolism of anandamide by fatty acid amidohydrolase (FAAH) at different intra- and extracellular pH values has been investigated in intact C6 rat glioma cells." | 3.72 | Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. ( Fowler, CJ; Holt, S, 2003) |
| " We have studied two liposoluble drugs, MPA and the analgesic ibuprofen, on glioma vascularization in vivo." | 3.71 | Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain. ( Altinoz, MA; Altug, T; Aydiner, A; Bilir, A; Bozcali, E; Ozar, E; Sav, A; Taskin, M, 2001) |
| " Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture." | 3.70 | Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000) |
| "The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats." | 3.67 | Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model. ( Del Maestro, RF; Farrell, CL; Megyesi, J, 1988) |
| " The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas." | 3.67 | Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986) |
Research
Studies (13)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Freitas, TE | 1 |
| Gomes, RN | 2 |
| Colquhoun, A | 3 |
| de Oliveira Silva, D | 2 |
| Benadiba, M | 1 |
| de M Costa, I | 1 |
| Santos, RL | 1 |
| Serachi, FO | 1 |
| Leidgens, V | 1 |
| Seliger, C | 1 |
| Jachnik, B | 1 |
| Welz, T | 1 |
| Leukel, P | 1 |
| Vollmann-Zwerenz, A | 1 |
| Bogdahn, U | 1 |
| Kreutz, M | 1 |
| Grauer, OM | 1 |
| Hau, P | 1 |
| Dagêstan, Y | 1 |
| Karaca, I | 1 |
| Bozkurt, ER | 1 |
| Bilir, A | 2 |
| Holt, S | 1 |
| Fowler, CJ | 2 |
| Janson, U | 1 |
| Johnson, RM | 1 |
| Wahlström, G | 1 |
| Stenström, A | 1 |
| Norström, K | 1 |
| Tiger, G | 1 |
| Roller, A | 1 |
| Bähr, OR | 1 |
| Streffer, J | 1 |
| Winter, S | 1 |
| Heneka, M | 1 |
| Deininger, M | 1 |
| Meyermann, R | 1 |
| Naumann, U | 1 |
| Gulbins, E | 1 |
| Weller, M | 1 |
| Vartak, S | 1 |
| Robbins, ME | 1 |
| Spector, AA | 1 |
| Casper, D | 1 |
| Lekhraj, R | 1 |
| Yaparpalvi, US | 1 |
| Pidel, A | 1 |
| Jaggernauth, WA | 1 |
| Werner, P | 1 |
| Tribius, S | 1 |
| Rowe, JD | 1 |
| LaSala, PA | 1 |
| Altinoz, MA | 1 |
| Ozar, E | 1 |
| Taskin, M | 1 |
| Bozcali, E | 1 |
| Altug, T | 1 |
| Aydiner, A | 1 |
| Sav, A | 1 |
| Farrell, CL | 2 |
| Megyesi, J | 1 |
| Del Maestro, RF | 2 |
| Reichman, HR | 1 |
Trials
1 trial available for ibuprofen and Glioma
| Article | Year |
|---|---|
Effects of Ibuprofen on orthotopic glioma model in rats.
Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Cel | 2012 |
Other Studies
12 other studies available for ibuprofen and Glioma
| Article | Year |
|---|---|
Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Glioma; Humans; Ibuprofen; Mitosi | 2016 |
Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Dru | 2014 |
Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Cycle Checkpoints; Cell Division; Cell | 2015 |
E series prostaglandins alter the proliferative, apoptotic and migratory properties of T98G human glioma cells in vitro.
Topics: Alprostadil; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Movement; Cell Proliferation; C | 2012 |
Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH.
Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Endocannabinoi | 2003 |
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship, | 1999 |
Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; ATP-Binding Cassette Transporters; C | 1999 |
The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress.
Topics: Animals; Antineoplastic Agents; Astrocytes; Astrocytoma; Cell Survival; Cyclooxygenase Inhibitors; D | 1999 |
Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture.
Topics: Acetaminophen; Adult; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Brain; Brain Neoplasms; Ce | 2000 |
Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Drug Therapy, Combination; Glioma | 2001 |
Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model.
Topics: Animals; Brain Neoplasms; Cell Division; Dose-Response Relationship, Drug; Evans Blue; Glioma; Ibupr | 1988 |
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm | 1986 |