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ibuprofen and Glioma

ibuprofen has been researched along with Glioma in 13 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model."9.16Effects of Ibuprofen on orthotopic glioma model in rats. ( Bilir, A; Bozkurt, ER; Dagêstan, Y; Karaca, I, 2012)
" For glioma, research has generally focused on diclofenac; however data on other NSAIDs, such as ibuprofen, is limited."7.81Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. ( Bogdahn, U; Grauer, OM; Hau, P; Jachnik, B; Kreutz, M; Leidgens, V; Leukel, P; Seliger, C; Vollmann-Zwerenz, A; Welz, T, 2015)
"The Diruthenium-Ibuprofen compound [Ru2Cl(Ibp)4] (or RuIbp) is known to cause significant inhibition of C6 rat glioma cell proliferation in vitro."7.80Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo. ( Benadiba, M; Colquhoun, A; de M Costa, I; de Oliveira Silva, D; Santos, RL; Serachi, FO, 2014)
"The metabolism of anandamide by fatty acid amidohydrolase (FAAH) at different intra- and extracellular pH values has been investigated in intact C6 rat glioma cells."7.72Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. ( Fowler, CJ; Holt, S, 2003)
" We have studied two liposoluble drugs, MPA and the analgesic ibuprofen, on glioma vascularization in vivo."7.71Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain. ( Altinoz, MA; Altug, T; Aydiner, A; Bilir, A; Bozcali, E; Ozar, E; Sav, A; Taskin, M, 2001)
" Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture."7.70Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000)
"The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats."7.67Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model. ( Del Maestro, RF; Farrell, CL; Megyesi, J, 1988)
"To determine the effects of ibuprofen (Ibp) on the vessel proliferation and necrosis in a rat glioma model."5.16Effects of Ibuprofen on orthotopic glioma model in rats. ( Bilir, A; Bozkurt, ER; Dagêstan, Y; Karaca, I, 2012)
" For glioma, research has generally focused on diclofenac; however data on other NSAIDs, such as ibuprofen, is limited."3.81Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms. ( Bogdahn, U; Grauer, OM; Hau, P; Jachnik, B; Kreutz, M; Leidgens, V; Leukel, P; Seliger, C; Vollmann-Zwerenz, A; Welz, T, 2015)
"The Diruthenium-Ibuprofen compound [Ru2Cl(Ibp)4] (or RuIbp) is known to cause significant inhibition of C6 rat glioma cell proliferation in vitro."3.80Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo. ( Benadiba, M; Colquhoun, A; de M Costa, I; de Oliveira Silva, D; Santos, RL; Serachi, FO, 2014)
"The metabolism of anandamide by fatty acid amidohydrolase (FAAH) at different intra- and extracellular pH values has been investigated in intact C6 rat glioma cells."3.72Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH. ( Fowler, CJ; Holt, S, 2003)
" We have studied two liposoluble drugs, MPA and the analgesic ibuprofen, on glioma vascularization in vivo."3.71Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain. ( Altinoz, MA; Altug, T; Aydiner, A; Bilir, A; Bozcali, E; Ozar, E; Sav, A; Taskin, M, 2001)
" Using cultures of rodent and human malignant glioma cell lines, we demonstrated that millimolar concentrations of acetylsalicylate, acetaminophen, and ibuprofen all significantly reduce cell numbers after several days of culture."3.70Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture. ( Casper, D; Jaggernauth, WA; LaSala, PA; Lekhraj, R; Pidel, A; Rowe, JD; Tribius, S; Werner, P; Yaparpalvi, US, 2000)
"The effects of long-term low- and high-dose ibuprofen on tumor growth and permeability were assessed in a glioma model in rats."3.67Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model. ( Del Maestro, RF; Farrell, CL; Megyesi, J, 1988)
" The authors have used the rat C6 glioma spheroid implantation model to compare the effects of two steroids (dexamethasone and methylprednisolone) and two NSAID's (ibuprofen and indomethacin) on protein extravasation caused by intracranial gliomas."3.67Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model. ( Del Maestro, RF; Farrell, CL; Reichman, HR, 1986)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19902 (15.38)18.7374
1990's3 (23.08)18.2507
2000's3 (23.08)29.6817
2010's5 (38.46)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Freitas, TE1
Gomes, RN2
Colquhoun, A3
de Oliveira Silva, D2
Benadiba, M1
de M Costa, I1
Santos, RL1
Serachi, FO1
Leidgens, V1
Seliger, C1
Jachnik, B1
Welz, T1
Leukel, P1
Vollmann-Zwerenz, A1
Bogdahn, U1
Kreutz, M1
Grauer, OM1
Hau, P1
Dagêstan, Y1
Karaca, I1
Bozkurt, ER1
Bilir, A2
Holt, S1
Fowler, CJ2
Janson, U1
Johnson, RM1
Wahlström, G1
Stenström, A1
Norström, K1
Tiger, G1
Roller, A1
Bähr, OR1
Streffer, J1
Winter, S1
Heneka, M1
Deininger, M1
Meyermann, R1
Naumann, U1
Gulbins, E1
Weller, M1
Vartak, S1
Robbins, ME1
Spector, AA1
Casper, D1
Lekhraj, R1
Yaparpalvi, US1
Pidel, A1
Jaggernauth, WA1
Werner, P1
Tribius, S1
Rowe, JD1
LaSala, PA1
Altinoz, MA1
Ozar, E1
Taskin, M1
Bozcali, E1
Altug, T1
Aydiner, A1
Sav, A1
Farrell, CL2
Megyesi, J1
Del Maestro, RF2
Reichman, HR1

Trials

1 trial available for ibuprofen and Glioma

ArticleYear
Effects of Ibuprofen on orthotopic glioma model in rats.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2012, Volume: 22, Issue:11

    Topics: Angiogenesis Inducing Agents; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Cel

2012

Other Studies

12 other studies available for ibuprofen and Glioma

ArticleYear
Axially-modified paddlewheel diruthenium(II,III)-ibuprofenato metallodrugs and the influence of the structural modification on U87MG and A172 human glioma cell proliferation, apoptosis, mitosis and migration.
    Journal of inorganic biochemistry, 2016, Volume: 165

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Glioma; Humans; Ibuprofen; Mitosi

2016
Growth inhibitory effects of the Diruthenium-Ibuprofen compound, [Ru2Cl(Ibp) 4], in human glioma cells in vitro and in the rat C6 orthotopic glioma in vivo.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2014, Volume: 19, Issue:6

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Dru

2014
Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms.
    PloS one, 2015, Volume: 10, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Cycle Checkpoints; Cell Division; Cell

2015
E series prostaglandins alter the proliferative, apoptotic and migratory properties of T98G human glioma cells in vitro.
    Lipids in health and disease, 2012, Dec-11, Volume: 11

    Topics: Alprostadil; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Movement; Cell Proliferation; C

2012
Anandamide metabolism by fatty acid amide hydrolase in intact C6 glioma cells. Increased sensitivity to inhibition by ibuprofen and flurbiprofen upon reduction of extra- but not intracellular pH.
    Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3

    Topics: Amidohydrolases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Endocannabinoi

2003
Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen.
    Archives of biochemistry and biophysics, 1999, Feb-15, Volume: 362, Issue:2

    Topics: Aging; Animals; Arachidonic Acids; Brain; Cell Extracts; Cell Survival; Dose-Response Relationship,

1999
Selective potentiation of drug cytotoxicity by NSAID in human glioma cells: the role of COX-1 and MRP.
    Biochemical and biophysical research communications, 1999, Jun-16, Volume: 259, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; ATP-Binding Cassette Transporters; C

1999
The selective cytotoxicity of gamma-linolenic acid (GLA) is associated with increased oxidative stress.
    Advances in experimental medicine and biology, 1999, Volume: 469

    Topics: Animals; Antineoplastic Agents; Astrocytes; Astrocytoma; Cell Survival; Cyclooxygenase Inhibitors; D

1999
Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture.
    Journal of neuro-oncology, 2000, Volume: 46, Issue:3

    Topics: Acetaminophen; Adult; Animals; Antineoplastic Agents; Apoptosis; Aspirin; Brain; Brain Neoplasms; Ce

2000
Vascularization pattern of C6 glioma is modified with medroxyprogesterone acetate and ibuprofen in Wistar rat brain.
    Pathology oncology research : POR, 2001, Volume: 7, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Neoplasms; Drug Therapy, Combination; Glioma

2001
Effect of ibuprofen on tumor growth in the C6 spheroid implantation glioma model.
    Journal of neurosurgery, 1988, Volume: 68, Issue:6

    Topics: Animals; Brain Neoplasms; Cell Division; Dose-Response Relationship, Drug; Evans Blue; Glioma; Ibupr

1988
Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model.
    Journal of neurosurgery, 1986, Volume: 65, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Capillary Perm

1986