ibuprofen has been researched along with Gastrointestinal Hemorrhage in 72 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibuprofen was first advocated as a chronic therapy for cystic fibrosis lung disease in 1995, following a favorable report of a 4-year controlled trial." | 8.84 | Ibuprofen therapy for cystic fibrosis lung disease: revisited. ( Konstan, MW, 2008) |
| "This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 8.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 7.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "Slower rates of FEV(1) decline are seen in children and adolescents with cystic fibrosis who are treated with ibuprofen." | 7.74 | Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis. ( Davis, PB; Konstan, MW; Schluchter, MD; Xue, W, 2007) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 6.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| "To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever." | 5.09 | The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999) |
| "In healthy subjects, treatment with rofecoxib, at 2 to 4 times the doses that are currently recommended for the treatment of patients with osteoarthritis, produced significantly less fecal blood loss than a therapeutic dose of ibuprofen and was equivalent to placebo." | 5.09 | A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects. ( Bolognese, JA; Bowen, B; Cagliola, A; Hunt, RH; James, C; Mortensen, ER; Quan, H; Simon, TJ, 2000) |
| "Adverse experiences were monitored in 1,681 patients with rheumatoid arthritis (RA) or osteoarthritis to evaluate the safety of benoxaprofen at daily doses up to 1,000 mg during long-term therapy." | 5.05 | Long-term safety of benoxaprofen. ( Mikulaschek, WM, 1980) |
| " Oral ibuprofen is associated with lower instance of necrotizing enterocolitis." | 4.95 | Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options. ( Keim-Malpass, J; Prescott, S, 2017) |
| "Ibuprofen was first advocated as a chronic therapy for cystic fibrosis lung disease in 1995, following a favorable report of a 4-year controlled trial." | 4.84 | Ibuprofen therapy for cystic fibrosis lung disease: revisited. ( Konstan, MW, 2008) |
| "This report demonstrates that gastrointestinal tract anatomical abnormalities or dysmotility may be contraindications for therapy with high-dose ibuprofen in patients with cystic fibrosis." | 4.82 | High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report. ( Anbar, RD; Mackey, JE, 2004) |
| "In a combined analysis of 8 trials of patients with osteoarthritis, treatment with rofecoxib was associated with a significantly lower incidence of PUBs than treatment with NSAIDs." | 4.80 | Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. ( Bolognese, JA; Harper, SE; Jensen, DM; Langman, MJ; Quan, H; Simon, TJ; Watson, DJ; Zhao, PL, 1999) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 3.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "Hypertension during pregnancy, even without intrauterine growth restriction, appeared to carry the same risk for MRB as exposure to ibuprofen and extrauterine growth restriction." | 3.79 | Risk factors of mild rectal bleeding in very low birth weight infants: a case control study. ( Ben Said, M; Hays, S; Jordan, I; Maucort-Boulch, D; Oulmaati, A; Picaud, JC, 2013) |
| "To compare the incidence of medical closure of patent ductus arteriosus (PDA) and adverse events (acute renal dysfunction, necrotizing enterocolitis, spontaneous intestinal perforation, and gastrointestinal bleeding) between preterm infants who received indomethacin and ibuprofen for the treatment of PDA." | 3.79 | Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants. ( Bali, V; Harabor, A; Kamaluddeen, M; Sivanandan, S; Soraisham, AS, 2013) |
| " She was on dabigatran for atrial fibrillation and aspirin, with intermittent intake of ibuprofen." | 3.78 | Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing "guidelines" in overdose and to find an "antidote"! ( Cirra, VR; Kamboj, J; Kamboj, R; Kottalgi, M; Shah, N, 2012) |
| "Slower rates of FEV(1) decline are seen in children and adolescents with cystic fibrosis who are treated with ibuprofen." | 3.74 | Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis. ( Davis, PB; Konstan, MW; Schluchter, MD; Xue, W, 2007) |
| "The risk of a newly diagnosed episode of upper gastrointestinal bleeding, acute liver and renal failure, agranulocytosis, aplastic anemia, severe skin disorders, and anaphylaxis was examined within 30 days after the first prescription for a low dose of diclofenac, naproxen, or ibuprofen in a cohort in the United Kingdom." | 3.70 | Low-dose diclofenac, naproxen, and ibuprofen cohort study. ( Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C, 1999) |
| "Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage." | 3.68 | Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac. ( Blower, PR; Gentry, C; Melarange, R; O'Connell, C, 1991) |
| " Ibuprofen-PC was well tolerated with no major adverse events observed." | 2.73 | Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients. ( Anand, BS; Lanza, FL; Lichtenberger, LM; Marathi, UK, 2008) |
| "Ibuprofen was statistically equivalent to paracetamol and better tolerated than aspirin (p <0." | 2.70 | Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions: results in 4291 patients. ( Le Parc, JM; Moore, N; Schneid, H; Van Ganse, E; Verrière, F; Wall, R, 2002) |
| " The amount of radioactivity excreted in faeces was measured during a placebo baseline phase of three days, a treatment phase of five days with thrice daily dosing of ASA, ibuprofen or lysine clonixinate and a subsequent wash-out phase of five days." | 2.68 | Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs. ( Bidlingmaier, A; Hammermaier, A; Nagyiványi, P; Pabst, G; Waitzinger, J, 1995) |
| "Indomethacin has been the standard treatment to close a PDA but is associated with renal, gastrointestinal, and cerebral side effects." | 2.66 | Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2020) |
| " Finally, the worldwide database of more than 77,000 patients monitored in postmarketing surveillance studies is examined to assess gastrointestinal side effects and the relation of age and sex to these adverse events." | 2.66 | Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. ( Meisel, AD, 1986) |
| "Ibuprofen has less effect on blood flow velocity to important organs." | 2.61 | Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2019) |
| " The incidence of a GI bleeding-related event increased with age and the use of concomitant medications, and there was a general, though not always statistically significant, ibuprofen dose-response relationship." | 2.48 | Over-the-counter ibuprofen and risk of gastrointestinal bleeding complications: a systematic literature review. ( Abramsky, S; Collins, J; McCarberg, B; Michels, SL; Paredes-Diaz, A; Reynolds, MW, 2012) |
| "Ibuprofen, paracetamol and placebo have similar tolerability and safety profiles in terms of gastrointestinal symptoms, asthma and renal adverse effects." | 2.45 | Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever. ( Kleijnen, J; Soares-Weiser, K; Southey, ER, 2009) |
| " Use of low risk drugs in low dosage as first line treatment would substantially reduce the morbidity and mortality due to serious gastrointestinal toxicity from these drugs." | 2.39 | Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis. ( Carson, JL; Fries, JT; Garcia Rodriguez, LA; Griffin, M; Hawkey, C; Henry, D; Hill, S; Lim, LL; Logan, R; Moride, Y; Perez Gutthann, S; Savage, R, 1996) |
| "Ibuprofen is a non-steroidal anti-inflammatory drug frequently used in children for fever and pain." | 1.39 | [Gastrointestinal bleeding following ingestion of low-dose ibuprofen]. ( Bodas Pinedo, A; Maluenda Carrillo, C; Vaquero Sosa, E, 2013) |
| " We present the case of a previously healthy 3-year-old boy who developed severe chronic gastric outlet obstruction and antral stenosis after a short-term ingestion of liquid ibuprofen at a dosage not thought to be associated with unfavorable effects." | 1.39 | Pneumatic pyloric dilatation for the treatment of gastric outlet obstruction in a child. ( Alvisi, P; Billi, P; Fascetti Leon, F; Gobbi, D; Lambertini, A; Lima, M, 2013) |
| "In physical examination features of upper respiratory tract infection were shown." | 1.35 | [Twenty-two months old girl with haemorrhagic gastritis as a complication after the nonsteroid anti-inflammatory drugs application--case report]. ( Jakubczyk, M; Mierzwa, G; Parzecka, M; Popławski, C; Swincow, G, 2008) |
| "Ibuprofen users also were somewhat less likely (31% vs 37%) to report GI pain at admission, but among hospitalized patients with endoscopic examinations were more likely (75% vs 58%) to be diagnosed with ulcer or hematemesis vs normal or gastritis/dyspepsia/reflux." | 1.32 | Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol. ( Blot, WJ; DuBois, R; Fischer, T; Friis, S; Lipworth, L; McLaughlin, JK; Mumma, M; Nielsen, GL; Sørensen, HT, 2004) |
| "Encapsulation of ibuprofen significantly reduced gastrointestinal toxicity especially at the higher dose level and drug was released enough to subject the GI mucosa to irritation, but without the usual toxic effects." | 1.29 | Acute gastrointestinal toxic effects of suspensions of unencapsulated and encapsulated ibuprofen in rats. ( Adeyeye, CM; Bricker, JD; Smith, WI; Vilivalam, VD, 1996) |
| "A Meckel's diverticulum is an unusual site of gastrointestinal bleeding in adults." | 1.28 | Bleeding from a Meckel's diverticulum after the use of ibuprofen. ( Estrada, R; Hollinger, FB; Mathur, S; Verseman, S, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (15.28) | 18.7374 |
| 1990's | 21 (29.17) | 18.2507 |
| 2000's | 21 (29.17) | 29.6817 |
| 2010's | 17 (23.61) | 24.3611 |
| 2020's | 2 (2.78) | 2.80 |
| Authors | Studies |
|---|---|
| Ohlsson, A | 2 |
| Shah, SS | 2 |
| Weinstein, RB | 2 |
| Ryan, PB | 1 |
| Berlin, JA | 2 |
| Schuemie, MJ | 1 |
| Swerdel, J | 2 |
| Fife, D | 2 |
| Ryan, P | 1 |
| Matcho, A | 1 |
| Schuemie, M | 1 |
| Patel, K | 1 |
| Cock, V | 1 |
| Edmonds, C | 1 |
| Cock, C | 1 |
| Thapa, SS | 1 |
| Scott, J | 1 |
| Gobbi, D | 1 |
| Billi, P | 1 |
| Fascetti Leon, F | 1 |
| Alvisi, P | 1 |
| Lambertini, A | 1 |
| Lima, M | 1 |
| Oulmaati, A | 1 |
| Hays, S | 1 |
| Ben Said, M | 1 |
| Maucort-Boulch, D | 1 |
| Jordan, I | 1 |
| Picaud, JC | 1 |
| Courtenay, L | 1 |
| Kwok, A | 1 |
| Keshava, A | 1 |
| Kopp, MA | 1 |
| Liebscher, T | 1 |
| Watzlawick, R | 1 |
| Martus, P | 1 |
| Laufer, S | 1 |
| Blex, C | 1 |
| Schindler, R | 1 |
| Jungehulsing, GJ | 1 |
| Knüppel, S | 1 |
| Kreutzträger, M | 1 |
| Ekkernkamp, A | 1 |
| Dirnagl, U | 1 |
| Strittmatter, SM | 1 |
| Niedeggen, A | 1 |
| Schwab, JM | 1 |
| Prescott, S | 1 |
| Keim-Malpass, J | 1 |
| Kalani, M | 1 |
| Shariat, M | 1 |
| Khalesi, N | 1 |
| Farahani, Z | 1 |
| Ahmadi, S | 1 |
| Lanza, FL | 1 |
| Marathi, UK | 1 |
| Anand, BS | 1 |
| Lichtenberger, LM | 1 |
| Mierzwa, G | 1 |
| Jakubczyk, M | 1 |
| Parzecka, M | 1 |
| Swincow, G | 1 |
| Popławski, C | 1 |
| Konstan, MW | 2 |
| Southey, ER | 1 |
| Soares-Weiser, K | 1 |
| Kleijnen, J | 1 |
| Grimaldi-Bensouda, L | 1 |
| Abenhaim, L | 1 |
| Michaud, L | 1 |
| Mouterde, O | 1 |
| Jonville-Béra, AP | 1 |
| Giraudeau, B | 1 |
| David, B | 1 |
| Autret-Leca, E | 1 |
| Michels, SL | 1 |
| Collins, J | 1 |
| Reynolds, MW | 1 |
| Abramsky, S | 1 |
| Paredes-Diaz, A | 1 |
| McCarberg, B | 1 |
| Sarici, SU | 1 |
| Dabak, O | 1 |
| Erdinc, K | 1 |
| Okutan, V | 1 |
| Lenk, MK | 1 |
| Vaquero Sosa, E | 1 |
| Bodas Pinedo, A | 1 |
| Maluenda Carrillo, C | 1 |
| Kamboj, J | 1 |
| Kottalgi, M | 1 |
| Cirra, VR | 1 |
| Shah, N | 1 |
| Kamboj, R | 1 |
| Sivanandan, S | 1 |
| Bali, V | 1 |
| Soraisham, AS | 1 |
| Harabor, A | 1 |
| Kamaluddeen, M | 1 |
| Hunt, RH | 3 |
| Harper, S | 2 |
| Callegari, P | 1 |
| Yu, C | 2 |
| Quan, H | 4 |
| Evans, J | 1 |
| James, C | 2 |
| Bowen, B | 2 |
| Rashid, F | 1 |
| Watson, DJ | 2 |
| Lee, M | 1 |
| Evans, JK | 1 |
| Oxenius, B | 1 |
| Mackey, JE | 1 |
| Anbar, RD | 1 |
| Brandt, LJ | 1 |
| Blot, WJ | 1 |
| Fischer, T | 1 |
| Nielsen, GL | 1 |
| Friis, S | 1 |
| Mumma, M | 1 |
| Lipworth, L | 1 |
| DuBois, R | 1 |
| McLaughlin, JK | 1 |
| Sørensen, HT | 1 |
| McCarthy, DM | 1 |
| Lewis, JD | 1 |
| Kimmel, SE | 1 |
| Localio, AR | 1 |
| Metz, DC | 1 |
| Farrar, JT | 1 |
| Nessel, L | 1 |
| Brensinger, C | 1 |
| McGibney, K | 1 |
| Strom, BL | 1 |
| Khosa, JK | 1 |
| Kimble, RM | 1 |
| Berezin, SH | 1 |
| Bostwick, HE | 1 |
| Halata, MS | 1 |
| Feerick, J | 1 |
| Newman, LJ | 1 |
| Medow, MS | 1 |
| Schluchter, MD | 1 |
| Xue, W | 1 |
| Davis, PB | 1 |
| Wehrmacher, WH | 1 |
| Messmore, HL | 1 |
| Haque, W | 1 |
| Jennes, S | 1 |
| Saidane, G | 1 |
| Fauville, JP | 1 |
| Ledoux, M | 1 |
| Colinet, B | 1 |
| Bunton, RW | 1 |
| Barrett, DC | 1 |
| Palmer, DG | 1 |
| Mikulaschek, WM | 1 |
| Bidlingmaier, A | 1 |
| Hammermaier, A | 1 |
| Nagyiványi, P | 1 |
| Pabst, G | 1 |
| Waitzinger, J | 1 |
| Müller, P | 1 |
| Simon, B | 1 |
| Cagnoni, PJ | 1 |
| Aledort, L | 1 |
| Rubin, RB | 1 |
| Saltzman, JR | 1 |
| Zawacki, JK | 1 |
| Ng, WT | 1 |
| Kong, CK | 1 |
| Wong, MK | 1 |
| Cheung, CH | 1 |
| Kaufman, DW | 2 |
| Kelly, JP | 2 |
| Sheehan, JE | 2 |
| Laszlo, A | 2 |
| Wiholm, BE | 2 |
| Alfredsson, L | 1 |
| Koff, RS | 2 |
| Shapiro, S | 2 |
| Gabb, GM | 1 |
| Henry, D | 1 |
| Lim, LL | 1 |
| Garcia Rodriguez, LA | 1 |
| Perez Gutthann, S | 1 |
| Carson, JL | 1 |
| Griffin, M | 1 |
| Savage, R | 1 |
| Logan, R | 1 |
| Moride, Y | 1 |
| Hawkey, C | 1 |
| Hill, S | 1 |
| Fries, JT | 1 |
| Adeyeye, CM | 1 |
| Bricker, JD | 1 |
| Vilivalam, VD | 1 |
| Smith, WI | 1 |
| Vu, CK | 1 |
| Korman, MG | 1 |
| Bejer, I | 1 |
| Davis, S | 1 |
| Hawkey, CJ | 1 |
| Pérez-Gutthann, S | 1 |
| García-Rodríguez, LA | 1 |
| Duque-Oliart, A | 1 |
| Varas-Lorenzo, C | 1 |
| Lesko, SM | 1 |
| Mitchell, AA | 1 |
| Pfau, PR | 1 |
| Lichenstein, GR | 1 |
| Langman, MJ | 1 |
| Jensen, DM | 1 |
| Harper, SE | 1 |
| Zhao, PL | 1 |
| Bolognese, JA | 2 |
| Simon, TJ | 2 |
| Mortensen, ER | 1 |
| Cagliola, A | 1 |
| Andrade, A | 1 |
| Namora, SF | 1 |
| Woisky, RG | 1 |
| Wiezel, G | 1 |
| Najjar, R | 1 |
| Sertié, JA | 1 |
| de Oliveira Silva, D | 1 |
| Olivencia, G | 1 |
| Foral, PA | 1 |
| Wilson, AF | 1 |
| Nystrom, KK | 1 |
| Le Parc, JM | 1 |
| Van Ganse, E | 1 |
| Moore, N | 1 |
| Wall, R | 1 |
| Schneid, H | 1 |
| Verrière, F | 1 |
| Engbaek, J | 1 |
| Paroli, E | 1 |
| Nencini, P | 1 |
| Anania, MC | 1 |
| Hunt, JN | 1 |
| Porro, GB | 1 |
| Corvi, G | 1 |
| Fuccella, LM | 1 |
| Goldaniga, GC | 1 |
| Valzelli, G | 1 |
| Pemberton, RE | 1 |
| Strand, LJ | 1 |
| Mathur, S | 1 |
| Verseman, S | 1 |
| Estrada, R | 1 |
| Hollinger, FB | 1 |
| Melarange, R | 2 |
| Moore, G | 1 |
| Blower, PR | 2 |
| Coates, ME | 1 |
| Ward, FW | 1 |
| Ronaasen, V | 1 |
| Güntert, TW | 1 |
| Schmitt, M | 1 |
| Dingemanse, J | 1 |
| Jonkman, JH | 1 |
| Gentry, C | 1 |
| O'Connell, C | 1 |
| Hershfield, NB | 1 |
| Giercksky, KE | 1 |
| Stalnikowicz, R | 1 |
| Eliakim, R | 1 |
| Ligumsky, M | 1 |
| Rachmilewitz, D | 1 |
| Suwa, T | 1 |
| Urano, H | 1 |
| Kohno, Y | 1 |
| Suzuki, A | 1 |
| Amano, T | 1 |
| Meisel, AD | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications[NCT02830178] | 144,337 participants (Actual) | Observational | 2016-01-31 | Completed | |||
| The Rho-Inhibitor Ibuprofen for the Treatment of Acute Spinal Cord Injury: Investigation of Safety, Feasibility and Pharmacokinetics[NCT02096913] | Phase 1 | 12 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study[NCT03103022] | Phase 1 | 20 participants (Actual) | Interventional | 2017-06-12 | Completed | ||
| Evaluation of the Effect of Sulforaphane in Broccoli Sprouts on Nrf2 Activation, Measures of Oxidative Stress, and Neutrophil Migration to Mucosal Surfaces in Healthy and CF Subjects[NCT01315665] | 15 participants (Actual) | Interventional | 2011-04-30 | Completed | |||
| The Role of IL-17 Neutrophils in CF Lung Inflammation[NCT02025829] | 14 participants (Actual) | Observational | 2014-02-28 | Completed | |||
| A Double-Blind Randomized Placebo Controlled Trial for Prevention of Tuberculosis-Immune Reconstitution Inflammatory Syndrome With Non-Steroid Anti-Inflammatory Drugs (NSAIDs) in HIV-Infected Adults[NCT02060006] | Phase 3 | 200 participants (Anticipated) | Interventional | 2014-04-30 | Recruiting | ||
| Effects of Hypoxia and Inflammation on Citrulline Synthesis by Ornithine Transcarbamylase in Human Enterocytes[NCT02820064] | 30 participants (Anticipated) | Interventional | 2016-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in gingival neutrophils measured after 5 days of study treatment (consuming broccoli sprouts). Patients will perform mouthwashes with normal saline. Neutrophil counts will be performed on fresh samples. Acridine orange will be added to the saline rinses and neutrophils will be counted under the microscope. (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | Neutrophils/mL (Log10) (Mean) |
|---|---|
| Healthy Volunteers | -0.06 |
| Subjects With Cystic Fibrosis | -0.02 |
Change in lymphocyte glutathione measurements after 5 days of study treatment (consuming broccoli sprouts). (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | Micro Molar (Mean) |
|---|---|
| Healthy Volunteers | 14.3 |
| Subjects With Cystic Fibrosis | 4.7 |
Change in urine bromotyrosine (measured by mass spectrometry) will be measured after 5 days of study treatment (consuming broccoli sprouts). (NCT01315665)
Timeframe: Baseline and end of 5 day treatment period
| Intervention | ng/mg creatinine (Log10) (Mean) |
|---|---|
| Healthy Volunteers | 0.09 |
| Subjects With Cystic Fibrosis | 0.01 |
Number of subjects with activated Nrf-2 in the cytoplasm of nasal epithelial cells after 5 days of study treatment (consuming broccoli sprouts) (NCT01315665)
Timeframe: Baseline and of end of 5 day treatment period
| Intervention | participants (Number) | |
|---|---|---|
| Baseline | Day 5, End of treatment | |
| Healthy Volunteers | 0 | 4 |
| Subjects With Cystic Fibrosis | 0 | 4 |
In the Exacerbation/IV Antibiotics Cohort--Subjects will serve as their own controls. The percentage of neutrophils (in sputum) positive for IL-17 was determined by flow cytometry for each subject at the beginning and end of treatment for a pulmonary exacerbation. Sputum IL-17 neutrophil counts will be compared to the change in lung function (FEV1) as determined by spirometry (American Thoracic Society standards). (NCT02025829)
Timeframe: End of Treatment, two weeks. Samples will be obtained from each study volunteer at the beginning of IV antibiotic treatment and at the completion of antibiotic treatment for a pulmonary exacerbation
| Intervention | % of neutrophils positive for IL-17 (Mean) |
|---|---|
| Begining of Exacerbation | 55 |
| End of Exacerbation | 4 |
In the Exacerbation/IV Antibiotics Cohort--Measurement of sputum inflammatory mediators by multiplex assay for IL-1β, IL-6, IL-8, and IL-17A. Neutrophil elastase determined by colorimetric assay. Measurements at the beginning of IV antibiotic treatment and after 2 weeks antibiotic treatment for a pulmonary exacerbation (NCT02025829)
Timeframe: End of Treatment, two weeks. Samples will be obtained from each study volunteer at the beginning of IV antibiotic treatment and at the completion of antibiotic treatment for a pulmonary exacerbation
| Intervention | pg/ml (Mean) | ||||
|---|---|---|---|---|---|
| IL-1b (pg/ml) | IL-6 (pg/ml) | IL-8 (pg/ml) | IL-17 (pg/ml) | Neutrophil elastase activity (pg/ml) | |
| Begining of Exacerbation | 2313 | 53 | 5785 | 302 | 195 |
| End of Exacerbation | 757 | 37 | 3428 | 147 | 53 |
11 reviews available for ibuprofen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Topics: Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duc | 2020 |
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Ductus Arteriosus, Patent; Enterocolit | 2019 |
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.
Topics: Biomarkers; Cardiac Catheterization; Conservative Treatment; Cyclooxygenase Inhibitors; Ductus Arter | 2017 |
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cystic Fibrosis; Disea | 2008 |
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cystic Fibrosis; Disea | 2008 |
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cystic Fibrosis; Disea | 2008 |
Ibuprofen therapy for cystic fibrosis lung disease: revisited.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Cystic Fibrosis; Disea | 2008 |
Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Anaphylaxis; Child; Fever; Gastrointestinal Hem | 2009 |
Over-the-counter ibuprofen and risk of gastrointestinal bleeding complications: a systematic literature review.
Topics: Algorithms; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Gastrointestinal Hemo | 2012 |
High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Barrett Esophagus; Combined Modality Therapy; C | 2004 |
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gas | 2002 |
Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of a collaborative meta-analysis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Cohort Studies; Dose-Response Relatio | 1996 |
Gastrointestinal bleeding after cold biopsy.
Topics: Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Biopsy; Cold Temperatu | 1998 |
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxyg | 1999 |
17 trials available for ibuprofen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastrointestinal Hemorrhag | 2016 |
A Comparison of Early Ibuprofen and Indomethacin Administration to Prevent Intraventricular Hemorrhage Among Preterm Infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Ductus Arte | 2016 |
Clinical trial: comparison of ibuprofen-phosphatidylcholine and ibuprofen on the gastrointestinal safety and analgesic efficacy in osteoarthritic patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non- | 2008 |
Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase | 2003 |
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloo | 2003 |
Long-term safety of benoxaprofen.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Blood Urea Nitrogen; C | 1980 |
Gastrointestinal blood loss induced by three different non-steroidal anti-inflammatory drugs.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chromium Radioisotopes; Clonixin; Cyclooxyge | 1995 |
Effects of ibuprofen lysinate and acetylsalicylic acid on gastric and duodenal mucosa. Randomized single-blind placebo-controlled endoscopic study in healthy volunteers.
Topics: Adult; Aspirin; Duodenum; Endoscopy; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Ibuprofen; | 1994 |
Nonsteroidal anti-inflammatory drug use in relation to major upper gastrointestinal bleeding.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Control Studies; Dic | 1993 |
The safety of acetaminophen and ibuprofen among children younger than two years old.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method; | 1999 |
A randomized trial measuring fecal blood loss after treatment with rofecoxib, ibuprofen, or placebo in healthy subjects.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chromium Radioisotopes; Cyclooxygenase 2; Cyclooxyge | 2000 |
Comparative tolerability of paracetamol, aspirin and ibuprofen for short-term analgesia in patients with musculoskeletal conditions: results in 4291 patients.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Non-Narcotic; Aspirin; Double-Blind Method; Female; Ga | 2002 |
A procedure for measuring gastric bleeding caused by drugs.
Topics: Aspirin; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Methods | 1979 |
Gastro-intestinal blood loss during administration of indoprofen, aspirin and ibuprofen.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Dose-Respon | 1977 |
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as | 1979 |
Influence of moclobemide on ibuprofen-induced faecal blood loss.
Topics: Benzamides; Double-Blind Method; Drug Synergism; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Moc | 1992 |
Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data.
Topics: Adult; Age Factors; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Ibu | 1986 |
44 other studies available for ibuprofen and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag | 2020 |
Channeling in the Use of Nonprescription Paracetamol and Ibuprofen in an Electronic Medical Records Database: Evidence and Implications.
Topics: Acetaminophen; Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; | 2017 |
Complications related to chronic supratherapeutic use of codeine containing compound analgesics in a cohort of patients presenting for codeine withdrawal.
Topics: Acetaminophen; Acidosis, Renal Tubular; Adult; Analgesics; Anemia; Codeine; Drug Combinations; Femal | 2018 |
Double pylorus.
Topics: Aged; Analgesics, Non-Narcotic; Asthma; Back Pain; Duodenal Diseases; Endoscopy; Gastric Fistula; Ga | 2018 |
Pneumatic pyloric dilatation for the treatment of gastric outlet obstruction in a child.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Combined Modality Therapy; Dilatation; Ga | 2013 |
Risk factors of mild rectal bleeding in very low birth weight infants: a case control study.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Feces; Female; Gastrointestina | 2013 |
Gastrointestinal: diaphragm disease: emerging cause of gastrointestinal obstruction and bleeding.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Female; Gastrointestinal Hemorrha | 2014 |
[Twenty-two months old girl with haemorrhagic gastritis as a complication after the nonsteroid anti-inflammatory drugs application--case report].
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastritis; Gastrointestinal Hemorrha | 2008 |
Clinical features and risk factors for upper gastrointestinal bleeding in children: a case-crossover study.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Confidence Intervals; Cross-Ove | 2010 |
An unreported complication of intravenously administered ibuprofen: gastrointestinal bleeding.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Gastrointestinal Hemorrhage; Hum | 2012 |
[Gastrointestinal bleeding following ingestion of low-dose ibuprofen].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Gastrointestinal Hemorrhage; Huma | 2013 |
Basic pain relievers. It's wise to use caution.
Topics: Acetaminophen; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chemical and Drug Induc | 2012 |
Direct thrombin inhibitors: a case indicating benefit from 'plasmapheresis' in toxicity: a call for establishing "guidelines" in overdose and to find an "antidote"!
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidotes; Antithrombins; Aspirin; Atrial Fibrillation; Ben | 2012 |
Effectiveness and safety of indomethacin versus ibuprofen for the treatment of patent ductus arteriosus in preterm infants.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Enterocolitis, Necrotizing; Fema | 2013 |
Bloody diarrhea in an elderly patient.
Topics: Aged; Angiography; Anti-Inflammatory Agents, Non-Steroidal; Case Management; Colitis, Ischemic; Colo | 2005 |
Outcome of upper gastro-intestinal bleeding and use of ibuprofen versus paracetamol.
Topics: Acetaminophen; Aged; Aged, 80 and over; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Ster | 2004 |
Risk of serious upper gastrointestinal toxicity with over-the-counter nonaspirin nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Diseases; Gastrointestinal He | 2005 |
Bleeding postoperatively from a Meckel diverticulum, secondary to NSAIDs: a cautionary note.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Gastric Mucosa; Gastrointestinal Hemorrhage; Hernia, | 2007 |
Gastrointestinal bleeding in children following ingestion of low-dose ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child, Preschool; Female; Gastritis; Gastrointestinal Hemor | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Clinical use of Ibuprofen is associated with slower FEV1 decline in children with cystic fibrosis.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Cystic Fibrosis; Female; Forced Expirato | 2007 |
Pain, analgesics, and the cardiovascular system.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Gastr | 2006 |
Transient selective factor X deficiency in a severely burned child.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Surface Area; Burns; Erythrocyt | 2008 |
Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis; Duodenal Ulcer; Female; Gastrointes | 1982 |
Gastrointestinal bleeding in hemophilia as a complication of the use of over the counter non-steroidal anti-inflammatory drugs.
Topics: Gastrointestinal Hemorrhage; Hemophilia A; Humans; Ibuprofen; Male; Middle Aged | 1994 |
Bicycle racing, Raynaud's phenomenon, and gastrointestinal bleeding.
Topics: Adult; Bicycling; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Raynaud Disease; Risk Fact | 1994 |
Re: Bleeding from a Meckel's diverticulum after the use of ibuprofen.
Topics: Adult; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Meckel Diverticulum | 1993 |
Fatal outcome of interaction between warfarin and a non-steroidal anti-inflammatory drug.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Drug Interactions; Fatal Outcome; Fem | 1996 |
Acute gastrointestinal toxic effects of suspensions of unencapsulated and encapsulated ibuprofen in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Duodenal Diseases; Gastrointesti | 1996 |
Naproxen sodium did not lead to substantially more upper gastrointestinal tract bleeding than ibuprofen during short term use as an analgesic.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Databases, Factual; Female; Gastrointestina | 1998 |
Low-dose diclofenac, naproxen, and ibuprofen cohort study.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agen | 1999 |
NSAIDs and alcohol: never the twain shall mix?
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase | 1999 |
The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption.
Topics: Acute Disease; Aged; Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Case-Contro | 1999 |
Synthesis and characterization of a diruthenium-ibuprofenato complex comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Gastrointestinal Hemorrhage; I | 2000 |
Life-threatening illness in a nontransfusable patient: a health care challenge.
Topics: Abdominal Pain; Adult; Analgesics, Non-Narcotic; Anemia, Iron-Deficiency; Appendicitis; Epoetin Alfa | 2000 |
Gastrointestinal bleeds associated with rofecoxib.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Gastrointestinal Hemorrhag | 2002 |
[Gastrointestinal hemorrhage during treatment with ibuprofen (Brufen)].
Topics: Aged; Aspirin; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Midd | 1977 |
Correlations of DNA, RNA and protein levels in duodenal mucosa with antiinflammatory potency and disposition to gut damage of non-steroidal agents. Comparative behaviour of glucametacine, indometacin, phenylbutazone and ibuprofen.
Topics: Animals; Anti-Inflammatory Agents; DNA; Duodenal Ulcer; Duodenum; Female; Gastrointestinal Hemorrhag | 1978 |
Bleeding from a Meckel's diverticulum after the use of ibuprofen.
Topics: Adult; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Intestinal Mucosa; Male; Meck | 1992 |
A comparison of indomethacin with ibuprofen on gastrointestinal mucosal integrity in conventional and germ-free rats.
Topics: Animals; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Germ-Free Life; Ibuprofen; Indomethaci | 1992 |
Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carrageenan; Diclofenac; E | 1991 |
Ibuprofen and severe gastrointestinal bleeding.
Topics: Aged; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Patient Education as Topic | 1990 |
Piroxicam and gastrointestinal bleeding.
Topics: Adult; Aged; Aged, 80 and over; Aspirin; Drug Utilization; Female; Gastrointestinal Hemorrhage; Hosp | 1986 |
Drug-induced bleeding of gastric leiomyoma.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Gastrointestinal Hemorrhage; Humans; | 1987 |
Comparative studies on the gastrointestinal lesions caused by several nonsteroidal anti-inflammatory agents in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Feces; Gastric Muco | 1987 |