Page last updated: 2024-10-28

ibuprofen and Gastroduodenal Ulcer

ibuprofen has been researched along with Gastroduodenal Ulcer in 47 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis."9.11Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004)
"In patients with OA, lumiracoxib 200 mg or 400 mg qd was associated with a significantly lower risk of gastroduodenal ulceration than ibuprofen 800 mg tid, and was similar to celecoxib 200 mg qd."9.11Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. ( Cousin, M; Fiedorowicz-Fabrycy, IF; Gitton, X; Hawkey, CC; Hoexter, G; Nasonov, EL; Pikhlak, EG; Svoboda, P, 2004)
" Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy."9.10Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002)
"Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations."9.06Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986)
"The protective effect of glucosamine on ibuprofen-induced peptic ulcer in male albino rats was studied with respect to changes in the volume of gastric juice, acid output, pepsin activity, activities of membrane bound ATPases, protein content, glycoprotein components and histopathology."7.74Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats. ( Anandan, R; Mathew, PT; Santhosh, S; Sini, TK, 2007)
"Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1."6.69Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000)
"To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis."5.11Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004)
"The Therapeutic Arthritis Research and Gastrointestinal Event Trial was a randomized, double-blind, 52-week study of lumiracoxib 400 mg once daily (two to four times the recommended dose for osteoarthritis) versus naproxen 500 mg twice daily or ibuprofen 800 mg three-times daily in patients with osteoarthritis."5.11Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics. ( Ehrsam, E; Farkouh, M; Gitton, X; Hawkey, CJ; Huels, J; Richardson, P, 2004)
"In patients with OA, lumiracoxib 200 mg or 400 mg qd was associated with a significantly lower risk of gastroduodenal ulceration than ibuprofen 800 mg tid, and was similar to celecoxib 200 mg qd."5.11Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. ( Cousin, M; Fiedorowicz-Fabrycy, IF; Gitton, X; Hawkey, CC; Hoexter, G; Nasonov, EL; Pikhlak, EG; Svoboda, P, 2004)
" Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy."5.10Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002)
"Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations."5.06Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986)
" Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0."5.05Long-term safety of benoxaprofen. ( Mikulaschek, WM, 1980)
"Prespecified analysis of all 8 double-blind, randomized phase 2b/3 rofecoxib osteoarthritis trials conducted from December 1996 through March 1998, including one 6-week dose-ranging study, two 6-week efficacy studies vs ibuprofen and placebo, two 1-year efficacy studies vs diclofenac, two 6-month endoscopy studies vs ibuprofen and placebo, and one 6-week efficacy study vs nabumetone and placebo."4.80Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. ( Bolognese, JA; Harper, SE; Jensen, DM; Langman, MJ; Quan, H; Simon, TJ; Watson, DJ; Zhao, PL, 1999)
"Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis."4.80Celecoxib clinical profile. ( Tive, L, 2000)
"To estimate the net cardiovascular (CV) (coronary heart disease, stroke, congestive heart failure), and gastrointestinal (GI) (peptic ulcer complications) risk-benefit public health impact of the use of celecoxib compared to non-selective NSAIDs in the arthritis population."3.74Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level. ( Castellsague, J; Maguire, A; Perez-Gutthann, S; Varas-Lorenzo, C, 2007)
"The protective effect of glucosamine on ibuprofen-induced peptic ulcer in male albino rats was studied with respect to changes in the volume of gastric juice, acid output, pepsin activity, activities of membrane bound ATPases, protein content, glycoprotein components and histopathology."3.74Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats. ( Anandan, R; Mathew, PT; Santhosh, S; Sini, TK, 2007)
"Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness."3.66An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982)
"Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1."2.69Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000)
" Indeed, no changes in serum pepsinogen I and II were noted in 80% of the patients in the higher dosage group and in more than 90% of the lower dosage group."2.67[Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen]. ( Klein, G; Kullich, W; Wallner, H, 1994)
" Finally, the worldwide database of more than 77,000 patients monitored in postmarketing surveillance studies is examined to assess gastrointestinal side effects and the relation of age and sex to these adverse events."2.66Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. ( Meisel, AD, 1986)
"Interindividual variability in drug metabolism is an important cause of adverse drug reactions and variability in drug efficiency."2.53How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity. ( Bilić, I; Božina, N; Dimovski, A; Domjanović, IK; Krasniqi, V, 2016)
" Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1."1.33Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin. ( Downing, JE; Ingram, MJ; Madden, JC; Rostron, C, 2005)
" NSAID dose-response curves produced using the two indices of damage showed that intestinal permeability is as sensitive and reproducible as ulceration, although changes could not be detected before visible ulceration occurred."1.29Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat. ( Ford, J; Houston, JB; Martin, SW, 1995)

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199010 (21.28)18.7374
1990's8 (17.02)18.2507
2000's24 (51.06)29.6817
2010's5 (10.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lolli, ML1
Cena, C1
Medana, C1
Lazzarato, L1
Morini, G1
Coruzzi, G1
Manarini, S1
Fruttero, R1
Gasco, A1
Alam, MM1
Husain, A1
Hasan, SM1
Anwer, T1
Jain, S1
Tran, S1
El Gendy, MA1
Kashfi, K1
Jurasz, P1
Velázquez-Martínez, CA1
Thapa, SS1
Scott, J1
Krasniqi, V1
Dimovski, A1
Domjanović, IK1
Bilić, I1
Božina, N1
Niebling, W1
McWhirter, KA1
Jones, RB1
McCormack, JP1
Rangno, R1
Geis, GS2
Sikes, DH1
Agrawal, NM2
Zhao, WW2
Kent, JD2
Recker, DP1
Verburg, KM2
Shirwaikar, A2
Bhilegaonkar, PM1
Malini, S1
Kumar, JS1
Hunt, RH1
Harper, S1
Watson, DJ2
Yu, C1
Quan, H2
Lee, M1
Evans, JK1
Oxenius, B1
Kivitz, AJ1
Nayiager, S1
Schimansky, T1
Gimona, A1
Thurston, HJ1
Hawkey, C1
Hawkey, CJ1
Farkouh, M1
Gitton, X2
Ehrsam, E1
Huels, J1
Richardson, P1
Hawkey, CC1
Svoboda, P1
Fiedorowicz-Fabrycy, IF1
Nasonov, EL1
Pikhlak, EG1
Cousin, M1
Hoexter, G1
Hollenz, M1
Labenz, J1
Downing, JE1
Madden, JC1
Ingram, MJ1
Rostron, C1
McCarthy, DM1
Gisbert, JP1
Abad-Santos, F1
Novalbos, J1
Khorrami, S1
Gallego-Sandín, S1
Rosado, A1
Gálvez-Múgica, MA1
Pajares, JM1
Ram, HN1
Mohapatra, P1
Varas-Lorenzo, C1
Maguire, A1
Castellsague, J1
Perez-Gutthann, S1
Santhosh, S1
Anandan, R1
Sini, TK1
Mathew, PT1
Pilotto, A1
Seripa, D1
Franceschi, M1
Scarcelli, C1
Colaizzo, D1
Grandone, E1
Niro, V1
Andriulli, A1
Leandro, G1
Di Mario, F1
Dallapiccola, B1
Halen, PK1
Chagti, KK1
Giridhar, R1
Yadav, MR1
Bunton, RW1
Barrett, DC1
Palmer, DG1
Mikulaschek, WM2
Ford, J1
Martin, SW1
Houston, JB1
Müller, P1
Koch, EM1
Simon, B1
LeLorier, J1
Kullich, W1
Wallner, H1
Klein, G1
Roth, SH1
Tindall, EA1
Jain, AK1
McMahon, FG1
April, PA1
Bockow, BI1
Cohen, SB1
Fleischmann, RM1
Dajani, EZ1
Langman, MJ1
Jensen, DM1
Harper, SE1
Zhao, PL1
Bolognese, JA1
Simon, TJ1
Dionne, R1
Blondon, H1
Silverstein, FE1
Faich, G1
Goldstein, JL1
Simon, LS1
Pincus, T1
Whelton, A1
Makuch, R1
Eisen, G1
Stenson, WF1
Burr, AM1
Lefkowith, JB1
Tive, L1
Tsokos, M1
Schmoldt, A1
Engbaek, J1
Cioli, V1
Putzolu, S1
Rossi, V1
Scorza Barcellona, P1
Corradino, C1
Turner, R1
Teixeira, AV1
Abrunhosa, R1
Poças, L1
Caldwell, JR1
Meisel, AD1
Johnson, JH1
Jick, H1
Hunter, JR1
Dickson, JF1

Reviews

4 reviews available for ibuprofen and Gastroduodenal Ulcer

ArticleYear
How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.
    Arhiv za higijenu rada i toksikologiju, 2016, Volume: 67, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme System; Di

2016
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
    The European journal of surgery. Supplement. : = Acta chirurgica. Supplement, 2002, Issue:587

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gas

2002
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
    JAMA, 1999, Nov-24, Volume: 282, Issue:20

    Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxyg

1999
Celecoxib clinical profile.
    Rheumatology (Oxford, England), 2000, Volume: 39 Suppl 2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec

2000

Trials

14 trials available for ibuprofen and Gastroduodenal Ulcer

ArticleYear
Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis.
    European journal of gastroenterology & hepatology, 2002, Volume: 14, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclo

2002
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
    The American journal of gastroenterology, 2003, Volume: 98, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloo

2003
Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.
    Alimentary pharmacology & therapeutics, 2004, Jun-01, Volume: 19, Issue:11

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygen

2004
Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics.
    Alimentary pharmacology & therapeutics, 2004, Jul-01, Volume: 20, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 In

2004
Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis.
    The Journal of rheumatology, 2004, Volume: 31, Issue:9

    Topics: Aged; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Incidence; Male;

2004
Comparison of gastric endoscopic lesions and tolerability to ibuprofen and ibuprofen-arginate in healthy subjects.
    Journal of clinical gastroenterology, 2005, Volume: 39, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arginine; Drug Combinations; Gastric Mucosa; Gastroscopy; H

2005
Long-term safety of benoxaprofen.
    The Journal of rheumatology. Supplement, 1980, Volume: 6

    Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Blood Urea Nitrogen; C

1980
[Protective effects of ranitidine in ibuprofen gastroduodenopathy. An endoscopic controlled double blind study].
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:5

    Topics: Adolescent; Adult; Double-Blind Method; Endoscopy, Gastrointestinal; Humans; Ibuprofen; Male; Peptic

1995
[Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen].
    Wiener klinische Wochenschrift, 1994, Volume: 106, Issue:7

    Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule;

1994
A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa.
    Archives of internal medicine, 1993, Nov-22, Volume: 153, Issue:22

    Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Endoscopy, Digestive

1993
[Specific cyclo-oxygenase inhibitors. 2. Gastric toxicity?].
    Presse medicale (Paris, France : 1983), 2000, Mar-11, Volume: 29, Issue:9

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhi

2000
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
    JAMA, 2000, Sep-13, Volume: 284, Issue:10

    Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin;

2000
Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States.
    The American journal of medicine, 1986, Apr-28, Volume: 80, Issue:4B

    Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Meth

1986
Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data.
    The American journal of medicine, 1986, Nov-28, Volume: 81, Issue:5B

    Topics: Adult; Age Factors; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Ibu

1986

Other Studies

29 other studies available for ibuprofen and Gastroduodenal Ulcer

ArticleYear
A new class of ibuprofen derivatives with reduced gastrotoxicity.
    Journal of medicinal chemistry, 2001, Oct-11, Volume: 44, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic N-Oxides; Edema; Gastric Mucos

2001
Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Furans; Li

2009
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
    Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase 1; Cyclooxy

2012
Double pylorus.
    BMJ case reports, 2018, Sep-04, Volume: 2018

    Topics: Aged; Analgesics, Non-Narcotic; Asthma; Back Pain; Duodenal Diseases; Endoscopy; Gastric Fistula; Ga

2018
[Bringing evidence to practice: obstacles and barriers].
    Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen, 2011, Volume: 105, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Comparative Effectiveness Research; Conflict of

2011
Accidental overdose of proprietary branded, combination analgesics available over the counter.
    British journal of hospital medicine (London, England : 2005), 2012, Volume: 73, Issue:11

    Topics: Acidosis; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Codeine; Di

2012
Digging for data from the COX-2 trials.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2002, Jun-25, Volume: 166, Issue:13

    Topics: Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Peptic Ulcer; Pyrazoles; Random

2002
Are selective COX 2 inhibitors superior to traditional NSAIDs? Pharmacia's response to editorial.
    BMJ (Clinical research ed.), 2002, Jul-20, Volume: 325, Issue:7356

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Cyclooxygenas

2002
The gastroprotective activity of the ethanol extract of Ageratum conyzoides.
    Journal of ethnopharmacology, 2003, Volume: 86, Issue:1

    Topics: Ageratum; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Female; Ibuprofen; Male; Peptic

2003
[Gastrointestinal complications under NSAID treatment in the doctor's office].
    MMW Fortschritte der Medizin, 2004, Dec-02, Volume: 146, Issue:49

    Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Clinical Trials as Topic; Dicl

2004
Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin.
    Biochemical and biophysical research communications, 2005, Aug-26, Volume: 334, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Esterification; Gastric Muco

2005
[Study results of routine clinical practice. Do rheumatism patients get substandard care?].
    MMW Fortschritte der Medizin, 2005, Nov-24, Volume: 147, Issue:47

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors;

2005
Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation.
    Indian journal of experimental biology, 2006, Volume: 44, Issue:6

    Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Ethanol; F

2006
Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular D

2007
Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.
    Journal of gastroenterology and hepatology, 2007, Volume: 22, Issue:6

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Acidity Determinatio

2007
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.
    Gastroenterology, 2007, Volume: 133, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cas

2007
Combining anticholinergic and anti-inflammatory activities into a single moiety: a novel approach to reduce gastrointestinal toxicity of ibuprofen and ketoprofen.
    Chemical biology & drug design, 2007, Volume: 70, Issue:5

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinergic Antagonists; Dru

2007
Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
    The New Zealand medical journal, 1982, Aug-25, Volume: 95, Issue:714

    Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis; Duodenal Ulcer; Female; Gastrointes

1982
An update on long-term efficacy and safety with benoxaprofen.
    European journal of rheumatology and inflammation, 1982, Volume: 5, Issue:2

    Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup

1982
Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat.
    Journal of pharmacological and toxicological methods, 1995, Volume: 34, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Radioisotopes; Cell Membrane Pe

1995
Patterns of prescription of nonsteroidal antiinflammatory drugs and gastroprotective agents.
    The Journal of rheumatology. Supplement, 1995, Volume: 43

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Cohort Studies; Confide

1995
Gastrointestinal toxicity of over-the-counter analgesics.
    The American journal of gastroenterology, 1998, Volume: 93, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg

1998
COX-2 inhibitors: better than ibuprofen for dental pain?
    Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995), 1999, Volume: 20, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; C

1999
Contribution of nonsteroidal anti-inflammatory drugs to deaths associated with peptic ulcer disease: a prospective toxicological analysis of autopsy blood samples.
    Archives of pathology & laboratory medicine, 2001, Volume: 125, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cause of Death; Chromatogra

2001
[Gastrointestinal hemorrhage during treatment with ibuprofen (Brufen)].
    Ugeskrift for laeger, 1977, Feb-14, Volume: 139, Issue:7

    Topics: Aged; Aspirin; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Midd

1977
The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats.
    Toxicology and applied pharmacology, 1979, Sep-15, Volume: 50, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Female; Ibuprofen; Indomethacin; Injections

1979
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
    American family physician, 1977, Volume: 16, Issue:1

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethaci

1977
Observations on the gastric mucosa of rheumatic patients before and after ibuprofen administration as studied by the pentagastrin test, endoscopy, and light and electron microscopy.
    The Journal of international medical research, 1977, Volume: 5, Issue:4

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Gastric Juice; Gastric Mucosa; Gastroscopy; Humans;

1977
A followup study of ibuprofen users.
    The Journal of rheumatology, 1985, Volume: 12, Issue:3

    Topics: Adult; Agranulocytosis; Erythema Multiforme; Female; Gastritis; Hematemesis; Humans; Ibuprofen; Male

1985