ibuprofen has been researched along with Gastroduodenal Ulcer in 47 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis." | 9.11 | Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004) |
| "In patients with OA, lumiracoxib 200 mg or 400 mg qd was associated with a significantly lower risk of gastroduodenal ulceration than ibuprofen 800 mg tid, and was similar to celecoxib 200 mg qd." | 9.11 | Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. ( Cousin, M; Fiedorowicz-Fabrycy, IF; Gitton, X; Hawkey, CC; Hoexter, G; Nasonov, EL; Pikhlak, EG; Svoboda, P, 2004) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 9.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| "Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations." | 9.06 | Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986) |
| "The protective effect of glucosamine on ibuprofen-induced peptic ulcer in male albino rats was studied with respect to changes in the volume of gastric juice, acid output, pepsin activity, activities of membrane bound ATPases, protein content, glycoprotein components and histopathology." | 7.74 | Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats. ( Anandan, R; Mathew, PT; Santhosh, S; Sini, TK, 2007) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 6.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| "To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis." | 5.11 | Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004) |
| "The Therapeutic Arthritis Research and Gastrointestinal Event Trial was a randomized, double-blind, 52-week study of lumiracoxib 400 mg once daily (two to four times the recommended dose for osteoarthritis) versus naproxen 500 mg twice daily or ibuprofen 800 mg three-times daily in patients with osteoarthritis." | 5.11 | Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics. ( Ehrsam, E; Farkouh, M; Gitton, X; Hawkey, CJ; Huels, J; Richardson, P, 2004) |
| "In patients with OA, lumiracoxib 200 mg or 400 mg qd was associated with a significantly lower risk of gastroduodenal ulceration than ibuprofen 800 mg tid, and was similar to celecoxib 200 mg qd." | 5.11 | Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis. ( Cousin, M; Fiedorowicz-Fabrycy, IF; Gitton, X; Hawkey, CC; Hoexter, G; Nasonov, EL; Pikhlak, EG; Svoboda, P, 2004) |
| " Overall, the data indicate that administration of valdecoxib offers similar efficacy for the treatment of osteoarthritis but improved upper-gastrointestinal safety compared with the conventional NSAIDs, ibuprofen and diclofenac, based on the significantly lower incidence of gastroduodenal ulcers detected by endoscopy." | 5.10 | Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis. ( Agrawal, NM; Kent, JD; Recker, DP; Sikes, DH; Verburg, KM; Zhao, WW, 2002) |
| "Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations." | 5.06 | Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986) |
| " Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0." | 5.05 | Long-term safety of benoxaprofen. ( Mikulaschek, WM, 1980) |
| "Prespecified analysis of all 8 double-blind, randomized phase 2b/3 rofecoxib osteoarthritis trials conducted from December 1996 through March 1998, including one 6-week dose-ranging study, two 6-week efficacy studies vs ibuprofen and placebo, two 1-year efficacy studies vs diclofenac, two 6-month endoscopy studies vs ibuprofen and placebo, and one 6-week efficacy study vs nabumetone and placebo." | 4.80 | Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. ( Bolognese, JA; Harper, SE; Jensen, DM; Langman, MJ; Quan, H; Simon, TJ; Watson, DJ; Zhao, PL, 1999) |
| "Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis." | 4.80 | Celecoxib clinical profile. ( Tive, L, 2000) |
| "To estimate the net cardiovascular (CV) (coronary heart disease, stroke, congestive heart failure), and gastrointestinal (GI) (peptic ulcer complications) risk-benefit public health impact of the use of celecoxib compared to non-selective NSAIDs in the arthritis population." | 3.74 | Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level. ( Castellsague, J; Maguire, A; Perez-Gutthann, S; Varas-Lorenzo, C, 2007) |
| "The protective effect of glucosamine on ibuprofen-induced peptic ulcer in male albino rats was studied with respect to changes in the volume of gastric juice, acid output, pepsin activity, activities of membrane bound ATPases, protein content, glycoprotein components and histopathology." | 3.74 | Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats. ( Anandan, R; Mathew, PT; Santhosh, S; Sini, TK, 2007) |
| "Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness." | 3.66 | An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 2.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| " Indeed, no changes in serum pepsinogen I and II were noted in 80% of the patients in the higher dosage group and in more than 90% of the lower dosage group." | 2.67 | [Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen]. ( Klein, G; Kullich, W; Wallner, H, 1994) |
| " Finally, the worldwide database of more than 77,000 patients monitored in postmarketing surveillance studies is examined to assess gastrointestinal side effects and the relation of age and sex to these adverse events." | 2.66 | Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data. ( Meisel, AD, 1986) |
| "Interindividual variability in drug metabolism is an important cause of adverse drug reactions and variability in drug efficiency." | 2.53 | How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity. ( Bilić, I; Božina, N; Dimovski, A; Domjanović, IK; Krasniqi, V, 2016) |
| " Following 4-h duration (acute) oral dosing of fasted male Wistar rats, 1." | 1.33 | Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin. ( Downing, JE; Ingram, MJ; Madden, JC; Rostron, C, 2005) |
| " NSAID dose-response curves produced using the two indices of damage showed that intestinal permeability is as sensitive and reproducible as ulceration, although changes could not be detected before visible ulceration occurred." | 1.29 | Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat. ( Ford, J; Houston, JB; Martin, SW, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (21.28) | 18.7374 |
| 1990's | 8 (17.02) | 18.2507 |
| 2000's | 24 (51.06) | 29.6817 |
| 2010's | 5 (10.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lolli, ML | 1 |
| Cena, C | 1 |
| Medana, C | 1 |
| Lazzarato, L | 1 |
| Morini, G | 1 |
| Coruzzi, G | 1 |
| Manarini, S | 1 |
| Fruttero, R | 1 |
| Gasco, A | 1 |
| Alam, MM | 1 |
| Husain, A | 1 |
| Hasan, SM | 1 |
| Anwer, T | 1 |
| Jain, S | 1 |
| Tran, S | 1 |
| El Gendy, MA | 1 |
| Kashfi, K | 1 |
| Jurasz, P | 1 |
| Velázquez-Martínez, CA | 1 |
| Thapa, SS | 1 |
| Scott, J | 1 |
| Krasniqi, V | 1 |
| Dimovski, A | 1 |
| Domjanović, IK | 1 |
| Bilić, I | 1 |
| Božina, N | 1 |
| Niebling, W | 1 |
| McWhirter, KA | 1 |
| Jones, RB | 1 |
| McCormack, JP | 1 |
| Rangno, R | 1 |
| Geis, GS | 2 |
| Sikes, DH | 1 |
| Agrawal, NM | 2 |
| Zhao, WW | 2 |
| Kent, JD | 2 |
| Recker, DP | 1 |
| Verburg, KM | 2 |
| Shirwaikar, A | 2 |
| Bhilegaonkar, PM | 1 |
| Malini, S | 1 |
| Kumar, JS | 1 |
| Hunt, RH | 1 |
| Harper, S | 1 |
| Watson, DJ | 2 |
| Yu, C | 1 |
| Quan, H | 2 |
| Lee, M | 1 |
| Evans, JK | 1 |
| Oxenius, B | 1 |
| Kivitz, AJ | 1 |
| Nayiager, S | 1 |
| Schimansky, T | 1 |
| Gimona, A | 1 |
| Thurston, HJ | 1 |
| Hawkey, C | 1 |
| Hawkey, CJ | 1 |
| Farkouh, M | 1 |
| Gitton, X | 2 |
| Ehrsam, E | 1 |
| Huels, J | 1 |
| Richardson, P | 1 |
| Hawkey, CC | 1 |
| Svoboda, P | 1 |
| Fiedorowicz-Fabrycy, IF | 1 |
| Nasonov, EL | 1 |
| Pikhlak, EG | 1 |
| Cousin, M | 1 |
| Hoexter, G | 1 |
| Hollenz, M | 1 |
| Labenz, J | 1 |
| Downing, JE | 1 |
| Madden, JC | 1 |
| Ingram, MJ | 1 |
| Rostron, C | 1 |
| McCarthy, DM | 1 |
| Gisbert, JP | 1 |
| Abad-Santos, F | 1 |
| Novalbos, J | 1 |
| Khorrami, S | 1 |
| Gallego-Sandín, S | 1 |
| Rosado, A | 1 |
| Gálvez-Múgica, MA | 1 |
| Pajares, JM | 1 |
| Ram, HN | 1 |
| Mohapatra, P | 1 |
| Varas-Lorenzo, C | 1 |
| Maguire, A | 1 |
| Castellsague, J | 1 |
| Perez-Gutthann, S | 1 |
| Santhosh, S | 1 |
| Anandan, R | 1 |
| Sini, TK | 1 |
| Mathew, PT | 1 |
| Pilotto, A | 1 |
| Seripa, D | 1 |
| Franceschi, M | 1 |
| Scarcelli, C | 1 |
| Colaizzo, D | 1 |
| Grandone, E | 1 |
| Niro, V | 1 |
| Andriulli, A | 1 |
| Leandro, G | 1 |
| Di Mario, F | 1 |
| Dallapiccola, B | 1 |
| Halen, PK | 1 |
| Chagti, KK | 1 |
| Giridhar, R | 1 |
| Yadav, MR | 1 |
| Bunton, RW | 1 |
| Barrett, DC | 1 |
| Palmer, DG | 1 |
| Mikulaschek, WM | 2 |
| Ford, J | 1 |
| Martin, SW | 1 |
| Houston, JB | 1 |
| Müller, P | 1 |
| Koch, EM | 1 |
| Simon, B | 1 |
| LeLorier, J | 1 |
| Kullich, W | 1 |
| Wallner, H | 1 |
| Klein, G | 1 |
| Roth, SH | 1 |
| Tindall, EA | 1 |
| Jain, AK | 1 |
| McMahon, FG | 1 |
| April, PA | 1 |
| Bockow, BI | 1 |
| Cohen, SB | 1 |
| Fleischmann, RM | 1 |
| Dajani, EZ | 1 |
| Langman, MJ | 1 |
| Jensen, DM | 1 |
| Harper, SE | 1 |
| Zhao, PL | 1 |
| Bolognese, JA | 1 |
| Simon, TJ | 1 |
| Dionne, R | 1 |
| Blondon, H | 1 |
| Silverstein, FE | 1 |
| Faich, G | 1 |
| Goldstein, JL | 1 |
| Simon, LS | 1 |
| Pincus, T | 1 |
| Whelton, A | 1 |
| Makuch, R | 1 |
| Eisen, G | 1 |
| Stenson, WF | 1 |
| Burr, AM | 1 |
| Lefkowith, JB | 1 |
| Tive, L | 1 |
| Tsokos, M | 1 |
| Schmoldt, A | 1 |
| Engbaek, J | 1 |
| Cioli, V | 1 |
| Putzolu, S | 1 |
| Rossi, V | 1 |
| Scorza Barcellona, P | 1 |
| Corradino, C | 1 |
| Turner, R | 1 |
| Teixeira, AV | 1 |
| Abrunhosa, R | 1 |
| Poças, L | 1 |
| Caldwell, JR | 1 |
| Meisel, AD | 1 |
| Johnson, JH | 1 |
| Jick, H | 1 |
| Hunter, JR | 1 |
| Dickson, JF | 1 |
4 reviews available for ibuprofen and Gastroduodenal Ulcer
| Article | Year |
|---|---|
How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 CYP2C8; Cytochrome P-450 Enzyme System; Di | 2016 |
Ulcers, Helicobacter pylori infection, platelets and gastrointestinal complications of non-steroidal anti-inflammatory drugs: what are the connections?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Diclofenac; Gas | 2002 |
Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cyclooxyg | 1999 |
Celecoxib clinical profile.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec | 2000 |
14 trials available for ibuprofen and Gastroduodenal Ulcer
| Article | Year |
|---|---|
Incidence of gastroduodenal ulcers associated with valdecoxib compared with that of ibuprofen and diclofenac in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclo | 2002 |
The gastrointestinal safety of the COX-2 selective inhibitor etoricoxib assessed by both endoscopy and analysis of upper gastrointestinal events.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cycloo | 2003 |
Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygen | 2004 |
Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 In | 2004 |
Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis.
Topics: Aged; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Female; Humans; Ibuprofen; Incidence; Male; | 2004 |
Comparison of gastric endoscopic lesions and tolerability to ibuprofen and ibuprofen-arginate in healthy subjects.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arginine; Drug Combinations; Gastric Mucosa; Gastroscopy; H | 2005 |
Long-term safety of benoxaprofen.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Blood Urea Nitrogen; C | 1980 |
[Protective effects of ranitidine in ibuprofen gastroduodenopathy. An endoscopic controlled double blind study].
Topics: Adolescent; Adult; Double-Blind Method; Endoscopy, Gastrointestinal; Humans; Ibuprofen; Male; Peptic | 1995 |
[Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen].
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1994 |
A controlled study comparing the effects of nabumetone, ibuprofen, and ibuprofen plus misoprostol on the upper gastrointestinal tract mucosa.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Endoscopy, Digestive | 1993 |
[Specific cyclo-oxygenase inhibitors. 2. Gastric toxicity?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhi | 2000 |
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2000 |
Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Meth | 1986 |
Clinical benefits and comparative safety of piroxicam. Analysis of worldwide clinical trials data.
Topics: Adult; Age Factors; Aged; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Ibu | 1986 |
29 other studies available for ibuprofen and Gastroduodenal Ulcer
| Article | Year |
|---|---|
A new class of ibuprofen derivatives with reduced gastrotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic N-Oxides; Edema; Gastric Mucos | 2001 |
Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Furans; Li | 2009 |
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase 1; Cyclooxy | 2012 |
Double pylorus.
Topics: Aged; Analgesics, Non-Narcotic; Asthma; Back Pain; Duodenal Diseases; Endoscopy; Gastric Fistula; Ga | 2018 |
[Bringing evidence to practice: obstacles and barriers].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Comparative Effectiveness Research; Conflict of | 2011 |
Accidental overdose of proprietary branded, combination analgesics available over the counter.
Topics: Acidosis; Adult; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Codeine; Di | 2012 |
Digging for data from the COX-2 trials.
Topics: Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Humans; Ibuprofen; Peptic Ulcer; Pyrazoles; Random | 2002 |
Are selective COX 2 inhibitors superior to traditional NSAIDs? Pharmacia's response to editorial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Clinical Trials as Topic; Cyclooxygenas | 2002 |
The gastroprotective activity of the ethanol extract of Ageratum conyzoides.
Topics: Ageratum; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ethanol; Female; Ibuprofen; Male; Peptic | 2003 |
[Gastrointestinal complications under NSAID treatment in the doctor's office].
Topics: Alcohol Drinking; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Clinical Trials as Topic; Dicl | 2004 |
Gastric and thymic assay of acute oral treatment of rats with nitric oxide esters of ibuprofen or indomethacin.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Esterification; Gastric Muco | 2005 |
[Study results of routine clinical practice. Do rheumatism patients get substandard care?].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; | 2005 |
Antioxidant and antiulcer activity of aqueous extract of a polyherbal formulation.
Topics: Administration, Oral; Alcohols; Animals; Anti-Ulcer Agents; Antioxidants; Benzothiazoles; Ethanol; F | 2006 |
Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular D | 2007 |
Protective effect of glucosamine against ibuprofen-induced peptic ulcer in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastric Acidity Determinatio | 2007 |
Genetic susceptibility to nonsteroidal anti-inflammatory drug-related gastroduodenal bleeding: role of cytochrome P450 2C9 polymorphisms.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Cas | 2007 |
Combining anticholinergic and anti-inflammatory activities into a single moiety: a novel approach to reduce gastrointestinal toxicity of ibuprofen and ketoprofen.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinergic Antagonists; Dru | 2007 |
Reintroduction of anti-inflammatory drug therapy after drug-associated gastro-intestinal disturbances.
Topics: Administration, Oral; Aged; Anti-Inflammatory Agents; Arthritis; Duodenal Ulcer; Female; Gastrointes | 1982 |
An update on long-term efficacy and safety with benoxaprofen.
Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup | 1982 |
Assessment of intestinal permeability changes induced by nonsteroidal anti-inflammatory drugs in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Carbon Radioisotopes; Cell Membrane Pe | 1995 |
Patterns of prescription of nonsteroidal antiinflammatory drugs and gastroprotective agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Cohort Studies; Confide | 1995 |
Gastrointestinal toxicity of over-the-counter analgesics.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxyg | 1998 |
COX-2 inhibitors: better than ibuprofen for dental pain?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; C | 1999 |
Contribution of nonsteroidal anti-inflammatory drugs to deaths associated with peptic ulcer disease: a prospective toxicological analysis of autopsy blood samples.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cause of Death; Chromatogra | 2001 |
[Gastrointestinal hemorrhage during treatment with ibuprofen (Brufen)].
Topics: Aged; Aspirin; Drug Interactions; Female; Gastrointestinal Hemorrhage; Humans; Ibuprofen; Male; Midd | 1977 |
The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Female; Ibuprofen; Indomethacin; Injections | 1979 |
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethaci | 1977 |
Observations on the gastric mucosa of rheumatic patients before and after ibuprofen administration as studied by the pentagastrin test, endoscopy, and light and electron microscopy.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Gastric Juice; Gastric Mucosa; Gastroscopy; Humans; | 1977 |
A followup study of ibuprofen users.
Topics: Adult; Agranulocytosis; Erythema Multiforme; Female; Gastritis; Hematemesis; Humans; Ibuprofen; Male | 1985 |