Page last updated: 2024-10-28

ibuprofen and Gastric Diseases

ibuprofen has been researched along with Gastric Diseases in 12 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"Ibuprofen is used to prevent high altitude headache (HAH) but its efficacy remains controversial."8.95Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis. ( Jia, Z; Lu, H; Wang, R; Xiong, J, 2017)
"Ibuprofen is used to prevent high altitude headache (HAH) but its efficacy remains controversial."4.95Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis. ( Jia, Z; Lu, H; Wang, R; Xiong, J, 2017)
" These results suggest that even the acute use of an NSAID (regardless of COX-2 selectivity) can induce gastric damage when combined with the long-term use of low-dose aspirin in an animal model."1.43Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy. ( Baglie, S; Baller, EM; Franco, GC; Gevert, MV; Lupepsa, AC; Moro, MG; Sanchez, PK; Tostes, AF, 2016)
"When caffeine was administered intraduodenally in pylorus-ligated rats, gastric acid secretion decreased in a dose-dependent manner, with an ED50 of 44."1.30Effect of caffeine on ibuprofen-induced gastric mucosal damage in rats. ( Furukawa, M; Kataoka, H; Koyama, R; Nakatsugi, S; Tanaka, Y, 1999)
"Encapsulation of ibuprofen significantly reduced gastrointestinal toxicity especially at the higher dose level and drug was released enough to subject the GI mucosa to irritation, but without the usual toxic effects."1.29Acute gastrointestinal toxic effects of suspensions of unencapsulated and encapsulated ibuprofen in rats. ( Adeyeye, CM; Bricker, JD; Smith, WI; Vilivalam, VD, 1996)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19902 (16.67)18.7374
1990's3 (25.00)18.2507
2000's3 (25.00)29.6817
2010's4 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Xiong, J1
Lu, H1
Wang, R1
Jia, Z1
Moro, MG1
Sanchez, PK1
Gevert, MV1
Baller, EM1
Tostes, AF1
Lupepsa, AC1
Baglie, S1
Franco, GC1
Giannuzzo, M1
Corrente, F1
Feeney, M1
Paoletti, L1
Paolicelli, P1
Tita, B1
Vitali, F1
Casadei, MA1
Caunedo-Alvarez, A1
Gómez-Rodríguez, BJ1
Romero-Vázquez, J1
Argüelles-Arias, F1
Romero-Castro, R1
García-Montes, JM1
Pellicer-Bautista, FJ1
Herrerías-Gutiérrez, JM1
Ilic, S1
Drmic, D1
Zarkovic, K1
Kolenc, D1
Brcic, L1
Radic, B1
Djuzel, V1
Blagaic, AB1
Romic, Z1
Dzidic, S1
Kalogjera, L1
Seiwerth, S1
Sikiric, P1
Fries, JF1
Murtagh, KN1
Bennett, M1
Zatarain, E1
Lingala, B1
Bruce, B1
Adeyeye, CM1
Bricker, JD1
Vilivalam, VD1
Smith, WI1
Koyama, R1
Kataoka, H1
Tanaka, Y1
Nakatsugi, S1
Furukawa, M1
Andrade, A1
Namora, SF1
Woisky, RG1
Wiezel, G1
Najjar, R1
Sertié, JA1
de Oliveira Silva, D1
Aabakken, L1
Larsen, S1
Osnes, M1
Higuchi, S1
Shioiri, Y1
Tanaka, N1
Otomo, S1
Aihara, H1
Lanza, FL1
Royer, GL1
Nelson, RS1
Rack, MF1
Seckman, CC1

Reviews

1 review available for ibuprofen and Gastric Diseases

ArticleYear
Efficacy of ibuprofen on prevention of high altitude headache: A systematic review and meta-analysis.
    PloS one, 2017, Volume: 12, Issue:6

    Topics: Altitude; Anti-Inflammatory Agents, Non-Steroidal; Databases, Factual; Headache; Humans; Ibuprofen;

2017

Trials

2 trials available for ibuprofen and Gastric Diseases

ArticleYear
Visual analogue scales for endoscopic evaluation of nonsteroidal anti-inflammatory drug-induced mucosal damage in the stomach and duodenum.
    Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:5

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Duodenal Disea

1990
Ethanol, aspirin, ibuprofen, and the gastroduodenal mucosa: an endoscopic assessment.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:10

    Topics: Adult; Aspirin; Drug Interactions; Drug Synergism; Duodenal Diseases; Ethanol; Female; Gastric Mucos

1985

Other Studies

9 other studies available for ibuprofen and Gastric Diseases

ArticleYear
Gastric and renal effects of COX-2 selective and non-selective NSAIDs in rats receiving low-dose aspirin therapy.
    Brazilian oral research, 2016, Nov-28, Volume: 30, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiovascular Diseases; Creatinine; Cycl

2016
pH-sensitive hydrogels of dextran: synthesis, characterization and in vivo studies.
    Journal of drug targeting, 2008, Volume: 16, Issue:9

    Topics: Animals; Dextrans; Drug Delivery Systems; Hydrogels; Hydrogen-Ion Concentration; Hydrolysis; Ibuprof

2008
Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy.
    Revista espanola de enfermedades digestivas, 2010, Volume: 102, Issue:2

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Capsule Endoscopy; Cyclooxygenase 2 Inhibitors

2010
Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats.
    European journal of pharmacology, 2011, Sep-30, Volume: 667, Issue:1-3

    Topics: Amino Acid Sequence; Animals; Anti-Ulcer Agents; Behavior, Animal; Brain; Brain Injuries; Gastric Mu

2011
The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Female; Humans; Ibuprofen;

2004
Acute gastrointestinal toxic effects of suspensions of unencapsulated and encapsulated ibuprofen in rats.
    Pharmaceutical research, 1996, Volume: 13, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Compounding; Duodenal Diseases; Gastrointesti

1996
Effect of caffeine on ibuprofen-induced gastric mucosal damage in rats.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:7

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Central Nervous Sy

1999
Synthesis and characterization of a diruthenium-ibuprofenato complex comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex.
    Journal of inorganic biochemistry, 2000, Jul-15, Volume: 81, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Gastrointestinal Hemorrhage; I

2000
[The modes of anti-inflammatory and analgesic actions of 2-[4-(3-methyl-2-butenyl) phenyl] propionic acid (TA-60) and 2-[4-(2,2-dichlorovinyl) phenyl] propionic acid (TA-668) and effect of TA-60 on the gastrointestinal tract].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 86, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Diarrhea

1985