Page last updated: 2024-10-28

ibuprofen and Erythema

ibuprofen has been researched along with Erythema in 19 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Erythema: Redness of the skin produced by congestion of the capillaries. This condition may result from a variety of disease processes.

Research Excerpts

ExcerptRelevanceReference
"Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents."9.12Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories. ( Jumbelic, LC; Liebel, FT; Southall, MD, 2006)
" Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made."7.81Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen. ( Abe, M; Aritomo, K; Hiasa, Y; Hirooka, M; Ikeda, Y; Koizumi, Y; Kumagi, T; Matsuura, B; Ochi, H; Tada, F; Tokumoto, Y; Watanabe, T, 2015)
"Ibuprofen may be a safe alternative to corticosteroids for select patients with vitiligo that are unable to photoadapt."5.30Effect of combination NSAID and NBUVB treatment in non-photoadapters-A pilot study. ( Griffith, J; Hamzavi, I; Mehta, C; Mehta, D; Mohammad, T; Nicholson, C, 2019)
"Topical administration of chemicals such as methyl nicotinate that induce erythema have been employed to measure the effectiveness of formulations containing anti-inflammatory agents."5.12Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories. ( Jumbelic, LC; Liebel, FT; Southall, MD, 2006)
"There was a statistically significant difference between pain measured by VAS, skin temperature and pain detection threshold measured at pad sites with pre-applied ibuprofen 5% cream and those with pre-applied aqueous cream, after elective DC cardioversion."5.11The effect of topical non-steroidal anti-inflammatory cream on the incidence and severity of cutaneous burns following external DC cardioversion. ( Ambler, JJ; Deakin, CD; Zideman, DA, 2005)
"The mechanism of topically applied methyl nicotinate-induced local cutaneous erythema was studied in normal human subjects."5.05Prostaglandins and nicotinate-provoked increase in cutaneous blood flow. ( Flowers, OV; Fortner, G; Kilpatrick, SJ; Reinhardt, LA; Streeter, WC; Wilkin, JK, 1985)
" Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made."3.81Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen. ( Abe, M; Aritomo, K; Hiasa, Y; Hirooka, M; Ikeda, Y; Koizumi, Y; Kumagi, T; Matsuura, B; Ochi, H; Tada, F; Tokumoto, Y; Watanabe, T, 2015)
"Ibuprofen is a commonly used non-steroidal anti-inflammatory drug administered to treat injuries, joint pain, and recurrent muscular skeletal pain."2.87Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers. ( Bhatt, A; Connolly, MP; Maganji, M, 2018)
"Mechanical and thermal hyperalgesia had been induced 24 h before by irradiating skin patches on the ventral side of the upper leg."2.69Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. ( Bickel, A; Dorfs, S; Forster, C; Handwerker, OH; Schmelz, M; Uhl, W, 1998)
"Ibuprofen and placebo were compared in a randomized, double-blind, cross-over study of 19 psoriatic patients receiving UV-B phototherapy to evaluate the symptomatic relief of UV-B-induced inflammation."2.66Ibuprofen in the treatment of UV-B-induced inflammation. ( Dodson, TB; Stern, RS, 1985)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19907 (36.84)18.7374
1990's3 (15.79)18.2507
2000's4 (21.05)29.6817
2010's5 (26.32)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maganji, M1
Connolly, MP1
Bhatt, A1
Mehta, C1
Mohammad, T1
Mehta, D1
Griffith, J1
Nicholson, C1
Hamzavi, I1
Watanabe, T1
Abe, M1
Tada, F1
Aritomo, K1
Ochi, H1
Koizumi, Y1
Tokumoto, Y1
Hirooka, M1
Kumagi, T1
Ikeda, Y1
Matsuura, B1
Hiasa, Y1
Gatson, NT1
Travers, JB2
Al-Hassani, M1
Warren, SJ1
Hyatt, AM1
Eismann, R1
Gaul, C1
Wohlrab, J1
Marsch, WC1
Fiedler, E1
Ambler, JJ1
Zideman, DA1
Deakin, CD1
Jackson, LA1
Dunstan, M1
Starkovich, P1
Dunn, J1
Yu, O1
Nelson, JC1
Rees, T1
Zavitkovsky, A1
Jumbelic, LC1
Liebel, FT1
Southall, MD1
Boulton, P1
Purdy, RA1
Bosch, EP1
Dodick, DW1
Gruber, K1
Engels, B1
Berner, G1
Wagener, HH1
Edwards, EK1
Horwitz, SN1
Frost, P1
Kumar, JR1
Haberman, HF1
Ranadive, NS1
Bickel, A1
Dorfs, S1
Schmelz, M1
Forster, C2
Uhl, W1
Handwerker, OH1
Adams, SS1
Bresloff, P1
Mason, CG1
Takase, K1
Masumoto, S1
Okumura, M1
Magerl, W1
Beck, A1
Geisslinger, G1
Gall, T1
Brune, K1
Handwerker, HO1
Johansson, EA1
Stern, RS1
Dodson, TB1
Wilkin, JK1
Fortner, G1
Reinhardt, LA1
Flowers, OV1
Kilpatrick, SJ1
Streeter, WC1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"Do NSAIDS or Executing Exercise Decrease Local Erythema, Site Swelling & Pain After INoculation: the NEED LESS PAIN Study"[NCT02807623]300 participants (Actual)Interventional2016-09-30Completed
Effect of Combination Non Steroidal Antiinflammatory Drugs and Narrowband UVB Treatment in Non-Photoadapters[NCT05256147]3 participants (Actual)Interventional2015-08-31Terminated (stopped due to difficulty in recruiting study population)
Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain[NCT02593721]Phase 2/Phase 350 participants (Actual)Interventional2015-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Participants With Edema

Swelling at vaccination site (NCT02807623)
Timeframe: baseline, 48-72 hours, and 21- 28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Participants With Erythema

Reddening of the skin at vaccination site reported as the total number of participants with erythema over the duration of the study. (NCT02807623)
Timeframe: baseline, 48- 72 hours, 21-28 days (3 points)

InterventionParticipants (Count of Participants)
Baseline0
48-72 Hours After Vaccination0
21-28 Days After Vaccination0

Lactate

A Lactate meter was used to test the exercise group for lactate readings. Two lactate tests was performed for the exercise group at Visit 1, both pre and post Influenza vaccination. The first lactate reading was taken after the blood draw.The second lactate reading was obtained from a fingerstick from the hand opposite to the vaccination arm, ideally within 3-8 minutes after the study subject completes pushups. (NCT02807623)
Timeframe: Immediately prior to Influenza vaccine and 3-8 minutes after Influenza vaccine was administered and after push-ups were completed.

Interventionmmol/L (Mean)
Lactate before pushupsLactate after pushups
Compound Exercise of Push-ups1.517.69

Level of Pain

Level of Pain will be measured by validated pain scale, using a scale of 0 ( best, no pain) to 10 (worst, as bad as imaginable, completely interferes). (NCT02807623)
Timeframe: baseline, 48-72 hours and at 21-28 days ( 3 points )

,,
Interventionunits on a scale (Mean)
Visit 1Visit 2Visit 3
Compound Exercise of Push-ups.14.19.13
Ibuprofen.39.56.28
Placebo.19.22.06

Serologic Response - A/California/7/2009

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups214.80345.09
Ibuprofen171.00239.25
Placebo216.75343.03

Serologic Response - A/Hong Kong / 4801/2014

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups149.22232.58
Ibuprofen177.78243.13
Placebo221.09296.66

Serologic Response - B/Brisbane/60/2008

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups26.0041.02
Ibuprofen17.4125.47
Placebo26.0934.09

Serologic Response - B/Phuket/3073/2013

Baseline lab specimen (visit 1, day 0, before immunization) and repeated between 21-28 days (visit 3) after immunization to measure serologic response (NCT02807623)
Timeframe: Day 0 and between 21-28 days (2 points)

,,
InterventionTiter (Mean)
Baseline (day 0, visit 1)Followup (between 21-28 days, visit 3)
Compound Exercise of Push-ups32.8949.07
Ibuprofen40.1647.34
Placebo36.6944.78

Reviews

1 review available for ibuprofen and Erythema

ArticleYear
Red ear syndrome: case report and review of the literature.
    Dermatology (Basel, Switzerland), 2011, Volume: 223, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Ear Diseases; Edema; Erythema; Female; Humans; Hyperhidrosis; Ibupr

2011

Trials

10 trials available for ibuprofen and Erythema

ArticleYear
Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers.
    Postgraduate medicine, 2018, Volume: 130, Issue:1

    Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Calcium Sulfate; Double-B

2018
Effect of combination NSAID and NBUVB treatment in non-photoadapters-A pilot study.
    Photodermatology, photoimmunology & photomedicine, 2019, Volume: 35, Issue:5

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Erythema; Female; Humans; Ibuprofen; Middle Aged; Pil

2019
The effect of topical non-steroidal anti-inflammatory cream on the incidence and severity of cutaneous burns following external DC cardioversion.
    Resuscitation, 2005, Volume: 65, Issue:2

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Burns, Electric; Double-Bli

2005
Prophylaxis with acetaminophen or ibuprofen for prevention of local reactions to the fifth diphtheria-tetanus toxoids-acellular pertussis vaccination: a randomized, controlled trial.
    Pediatrics, 2006, Volume: 117, Issue:3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Pres

2006
Establishing a minimal erythema concentration of methyl nicotinate for optimum evaluation of anti-inflammatories.
    Skin pharmacology and physiology, 2006, Volume: 19, Issue:3

    Topics: Administration, Topical; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dermatitis, Contact; Erythe

2006
Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man.
    Pain, 1998, Volume: 76, Issue:3

    Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diuresis; Double-Bli

1998
Differential effects of dipyrone, ibuprofen, and paracetamol on experimentally induced pain in man.
    Agents and actions, 1992, Volume: 35, Issue:1-2

    Topics: Acetaminophen; Adult; Analgesia; Dipyrone; Erythema; Female; Humans; Ibuprofen; Male; Muscle, Smooth

1992
Proquazone: a treatment for lymphocytic infiltration of the skin. Comparative study with 2 other nonsteroid anti-inflammatory drugs.
    Dermatologica, 1987, Volume: 174, Issue:3

    Topics: Adult; Aged; Clinical Trials as Topic; Erythema; Female; Humans; Ibuprofen; Indomethacin; Lymphocyte

1987
Ibuprofen in the treatment of UV-B-induced inflammation.
    Archives of dermatology, 1985, Volume: 121, Issue:4

    Topics: Adult; Clinical Trials as Topic; Dermatitis; Double-Blind Method; Erythema; Humans; Ibuprofen; Psori

1985
Prostaglandins and nicotinate-provoked increase in cutaneous blood flow.
    Clinical pharmacology and therapeutics, 1985, Volume: 38, Issue:3

    Topics: Administration, Oral; Administration, Topical; Adult; Aspirin; Double-Blind Method; Doxepin; Drug In

1985

Other Studies

8 other studies available for ibuprofen and Erythema

ArticleYear
Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:4

    Topics: Adult; Asian People; Chemical and Drug Induced Liver Injury; Drug Eruptions; Erythema; Female; Fever

2015
Progression of toxic epidermal necrolysis after tanning bed exposure.
    Archives of dermatology, 2011, Volume: 147, Issue:6

    Topics: Cell Line; Disease Progression; Erythema; Female; Humans; Ibuprofen; Immunoglobulins, Intravenous; K

2011
Primary and secondary red ear syndrome: implications for treatment.
    Cephalalgia : an international journal of headache, 2007, Volume: 27, Issue:2

    Topics: Aged; Amines; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; Ear

2007
[Pharmacologic-toxicologic study of an ibuprofen-containing creme].
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:8

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Erythema; Female; Gr

1983
Reduction of the erythema response to ultraviolet light by nonsteroidal antiinflammatory agents.
    Archives of dermatological research, 1982, Volume: 272, Issue:3-4

    Topics: Anti-Inflammatory Agents; Aspirin; Erythema; Humans; Ibuprofen; Indomethacin; Ultraviolet Rays

1982
Modulation of 8-methoxypsoralen-photoinduced cutaneous inflammatory reactions by various chemotherapeutic agents in vivo.
    Photochemistry and photobiology, 1996, Volume: 63, Issue:4

    Topics: Acetophenones; Animals; Capillary Permeability; Erythema; Ibuprofen; Indoles; Indomethacin; Masoproc

1996
Pharmacological differences between the optical isomers of ibuprofen: evidence for metabolic inversion of the (-)-isomer.
    The Journal of pharmacy and pharmacology, 1976, Volume: 28, Issue:3

    Topics: Acetylcholine; Animals; Cattle; Cyclooxygenase Inhibitors; Erythema; Guinea Pigs; Ibuprofen; In Vitr

1976
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu

1975