Page last updated: 2024-10-28

ibuprofen and Endotoxemia

ibuprofen has been researched along with Endotoxemia in 12 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.

Research Excerpts

ExcerptRelevanceReference
"The primary purpose of this study was to measure the influence of ibuprofen use during the 160-km Western States Endurance Run on endotoxemia, inflammation, and plasma cytokines."9.12Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. ( Davis, JM; Dumke, CL; Henson, DA; Lind, RH; McAnulty, LS; McAnulty, SR; Morrow, JD; Murphy, EA; Nieman, DC; Oley, K; Utter, AC, 2006)
"To measure the effect of experimental endotoxemia and anti-inflammatory therapy on plasma dehydroepiandrosterone (DHEA) levels in humans."9.09Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans. ( Bornstein, SR; Chrousos, GP; Preas, HL; Suffredini, AF; Tauchnitz, R; Wolkersdörfer, GW, 2000)
"Ibuprofen, a cyclooxygenase inhibitor, improves pulmonary and cardiovascular injury in endotoxemia."7.70Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia. ( Heidemann, SM; Ofenstein, JP; Sarnaik, AP, 1999)
"Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease."5.42Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015)
"The primary purpose of this study was to measure the influence of ibuprofen use during the 160-km Western States Endurance Run on endotoxemia, inflammation, and plasma cytokines."5.12Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition. ( Davis, JM; Dumke, CL; Henson, DA; Lind, RH; McAnulty, LS; McAnulty, SR; Morrow, JD; Murphy, EA; Nieman, DC; Oley, K; Utter, AC, 2006)
"To measure the effect of experimental endotoxemia and anti-inflammatory therapy on plasma dehydroepiandrosterone (DHEA) levels in humans."5.09Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans. ( Bornstein, SR; Chrousos, GP; Preas, HL; Suffredini, AF; Tauchnitz, R; Wolkersdörfer, GW, 2000)
"To evaluate the effects of endotoxemia on respiratory controller function, 12 subjects were randomized to receive endotoxin or saline; six also received ibuprofen, a cyclooxygenase inhibitor, and six received placebo."5.09Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. ( Banks, SM; Godin, PJ; Jubran, A; Preas, HL; Reda, D; Suffredini, AF; Tobin, MJ; Vandivier, RW, 2001)
"The objective of our study was to determine the role of ibuprofen in protecting neutropenic rats from cardiopulmonary injury due to endotoxemia."3.71Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats. ( Daphtary, KM; Glibetic, M; Heidemann, SM, 2001)
" To assess the role of MIP-1alpha and MIP-1beta in human inflammation, healthy subjects were studied during experimental endotoxemia with prior administration of ibuprofen, a cyclooxygenase inhibitor, or dimeric p75 tumor necrosis factor (TNF)-alpha receptor, a TNF antagonist; septic patients were also studied."3.70Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. ( Banks, SM; O'Grady, NP; Preas, HL; Reda, D; Suffredini, AF; Tropea, M; Vandivier, RW, 1999)
"Ibuprofen, a cyclooxygenase inhibitor, improves pulmonary and cardiovascular injury in endotoxemia."3.70Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia. ( Heidemann, SM; Ofenstein, JP; Sarnaik, AP, 1999)
"Sepsis is still a major cause of death and many efforts have been made to improve the physical condition of sepsis patients and to reduce the high mortality rate associated with this disease."1.42Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis. ( Barcena Varela, S; Brandenburg, K; Drömann, D; Ferrer-Espada, R; Goldmann, T; Gutsmann, T; Heinbockel, L; Martinez de Tejada, G; Marwitz, S; Mier, W; Reiling, N; Schürholz, T, 2015)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (41.67)18.2507
2000's5 (41.67)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lee, HH1
Shin, JS1
Lee, WS1
Ryu, B1
Jang, DS1
Lee, KT1
Heinbockel, L1
Marwitz, S1
Barcena Varela, S1
Ferrer-Espada, R1
Reiling, N1
Goldmann, T1
Gutsmann, T1
Mier, W1
Schürholz, T1
Drömann, D1
Brandenburg, K1
Martinez de Tejada, G1
Nieman, DC1
Henson, DA1
Dumke, CL1
Oley, K1
McAnulty, SR1
Davis, JM1
Murphy, EA1
Utter, AC1
Lind, RH1
McAnulty, LS1
Morrow, JD1
Santos, AA1
Wilmore, DW1
Mansilla-Roselló, A1
Ferrón-Orihuela, JA1
Ruiz-Cabello, F1
Garrote-Lara, D1
Delgado-Carrasco, S1
Tamayo-Pozo, F1
Bornstein, SR2
Preas, HL5
Chrousos, GP2
Suffredini, AF5
O'Grady, NP1
Tropea, M1
Reda, D2
Vandivier, RW2
Banks, SM2
Heidemann, SM2
Ofenstein, JP1
Sarnaik, AP1
Wolkersdörfer, GW1
Tauchnitz, R1
Nylen, ES1
Snider, RH1
Becker, KL1
White, JC1
Agosti, JM1
Jubran, A1
Godin, PJ1
Tobin, MJ1
Daphtary, KM1
Glibetic, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Milk Fat Globule Membrane (MFGM) on Gut Barrier Protection in Runners[NCT03176212]14 participants (Actual)Interventional2012-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for ibuprofen and Endotoxemia

ArticleYear
Ibuprofen use, endotoxemia, inflammation, and plasma cytokines during ultramarathon competition.
    Brain, behavior, and immunity, 2006, Volume: 20, Issue:6

    Topics: Adult; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Colony-Stimulating Factors; Cr

2006
The systemic inflammatory response: perspective of human endotoxemia.
    Shock (Augusta, Ga.), 1996, Volume: 6 Suppl 1

    Topics: Body Temperature; Cytokines; Endotoxemia; Endotoxins; Escherichia coli Infections; Heart Rate; Human

1996
Circulating leptin levels during acute experimental endotoxemia and antiinflammatory therapy in humans.
    The Journal of infectious diseases, 1998, Volume: 178, Issue:3

    Topics: Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Endotoxemia; Endotoxins

1998
Plasma dehydroepiandrosterone levels during experimental endotoxemia and anti-inflammatory therapy in humans.
    Critical care medicine, 2000, Volume: 28, Issue:6

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Dehydroepiandrosterone; E

2000
Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway.
    American journal of respiratory and critical care medicine, 2001, Aug-15, Volume: 164, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis; Carbon Dioxide; Dyspnea; Endotox

2001

Other Studies

7 other studies available for ibuprofen and Endotoxemia

ArticleYear
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Anim

2016
Therapeutical Administration of Peptide Pep19-2.5 and Ibuprofen Reduces Inflammation and Prevents Lethal Sepsis.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: Amino Acid Sequence; Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Dinopr

2015
Interleukin-1beta and ibuprofen effects on CD4/CD8 cells after endotoxic challenge.
    The Journal of surgical research, 1996, Volume: 65, Issue:1

    Topics: Animals; CD4-CD8 Ratio; Dinoprostone; Endotoxemia; Female; Ibuprofen; Interleukin-1; Lymphocyte Subs

1996
Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis.
    The Journal of infectious diseases, 1999, Volume: 179, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigens, CD; Chemokine CCL3; Chemokine CCL4; Child; Cyc

1999
Ibuprofen attenuates cardiopulmonary dysfunction by modifying vascular tone in endotoxemia.
    Prostaglandins, leukotrienes, and essential fatty acids, 1999, Volume: 60, Issue:3

    Topics: Animals; Blood Pressure; Cardiovascular System; Cyclooxygenase Inhibitors; Endotoxemia; Ibuprofen; L

1999
Effects of anti-inflammatory agents on serum levels of calcitonin precursors during human experimental endotoxemia.
    The Journal of infectious diseases, 2001, Aug-01, Volume: 184, Issue:3

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; C-Reactive Protein; Calciton

2001
Ibuprofen attenuates early lung injury in endotoxemic, neutropenic rats.
    Prostaglandins, leukotrienes, and essential fatty acids, 2001, Volume: 65, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Chemokine CXCL2; Che

2001