ibuprofen and Edema
ibuprofen has been researched along with Edema in 179 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, etodolac use showed better results regarding pain, trismus and edema." | 9.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 9.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains." | 9.12 | Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 7.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "A case of periorbital edema associated with separate courses of ibuprofen and naproxen is reported." | 7.76 | Periorbital edema associated with separate courses of ibuprofen and naproxen. ( Balas, M; Plakogiannis, R; Sinnett, M, 2010) |
| "PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment." | 7.74 | Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. ( Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J, 2007) |
| "We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria." | 7.73 | Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005) |
| " Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability." | 7.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "Ibuprofen increases tissue perfusion and reduces edema formation in scald burned rabbit ears." | 7.70 | Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 7.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor." | 7.67 | Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987) |
| "Paw edema was analyzed using a plethysmometer." | 5.48 | Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats. ( Casarin, RCV; Casati, MZ; Cirano, FR; Corrêa, MG; Napimoga, MH; Pimentel, SP; Pires, PR; Ribeiro, FV, 2018) |
| " However, etodolac use showed better results regarding pain, trismus and edema." | 5.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "This randomized controlled clinical trial aimed to evaluate the preemptive effects of acetaminophen, ibuprofen, ketoprofen, nimesulide or dexamethasone on postoperative pain and edema in the surgical removal of impacted third molars." | 5.41 | Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial. ( Araújo, AVA; Costa, FO; Cota, LOM; Cyrino, RM; Pinto Júnior, AAC; Santos, BFE, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 5.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains." | 5.12 | Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006) |
| "The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) and rheumatoid arthritis (RA) patients." | 5.12 | Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. ( Lefkowith, JL; Verburg, KM; West, CR; Whelton, A, 2006) |
| " Further, 11-14 demonstrated comparable anti-inflammatory activity with ibuprofen in carrageenan-induced rat paw edema assay and appreciable inhibition of lipopolysaccharide (LPS) induced pro-inflammatory mediators (TNF-α and IL-1β) in Sprague Dawley (SD) rats." | 3.81 | 2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies. ( Bairwa, K; Bhutani, KK; Gangwal, R; Jachak, SM; Jaiswal, G; Patel, NK; Sangamwar, AT, 2015) |
| "9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy." | 3.80 | S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 3.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo." | 3.77 | Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives. ( Bantu, R; Gaikwad, HK; Mateti, J; Nagarapu, L; Prameela Subhashini, NJ; Sheeba Rani, M, 2011) |
| "A case of periorbital edema associated with separate courses of ibuprofen and naproxen is reported." | 3.76 | Periorbital edema associated with separate courses of ibuprofen and naproxen. ( Balas, M; Plakogiannis, R; Sinnett, M, 2010) |
| "A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body weight." | 3.74 | Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. ( Haque, N; Molvi, KI; Sudarsanam, V; Vasu, KK; Yerande, SG, 2007) |
| "Substituted thiazoles with different structural features were synthesized and screened for their anti-inflammatory activity in acute carrageenin induced rat paw edema model and chronic formalin induced rat paw edema model." | 3.74 | 2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. ( Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S, 2008) |
| " Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen." | 3.74 | Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. ( Daidone, G; Harrak, Y; Plescia, S; Pujol, MD; Rosell, G; Schillaci, D, 2007) |
| "PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment." | 3.74 | Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. ( Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J, 2007) |
| "We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria." | 3.73 | Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005) |
| "The sub-effective dose of VN potentiated anti-inflammatory activity of phenlbutazone and ibuprofen significantly in carrageenin induced hind paw oedema and cotton pellet granuloma models." | 3.73 | Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs. ( Gupta, RK; Tandon, VR, 2006) |
| "0032 muM) and COX-2 selectivity (SI > 120 000), 14s exhibited moderate antiinflammatory activity compared to celecoxib in a carrageenan-induced rat paw edema assay." | 3.72 | Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. ( Amini, M; Habeeb, AG; Knaus, EE; Li, H; Praveen Rao, PN, 2003) |
| " Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h." | 3.71 | Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002) |
| " Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability." | 3.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "Ibuprofen increases tissue perfusion and reduces edema formation in scald burned rabbit ears." | 3.70 | Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000) |
| " Intraplantar injection of arachidonic acid (AA) into the rat paw was followed by a rapid and sustained (> or = 4h) inflammatory oedema." | 3.70 | Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat. ( Angel, I; Arbilla, S; Pichat, P, 1998) |
| " The 2-(2,3-dihydro-1, 4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay." | 3.69 | Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids. ( Pujol, MD; Rosell, G; Vázquez, MT, 1996) |
| "The antiphlogistic Ibuprofen incorporated in liposomes caused a decrease of the inflammatory edema induced by Carrageenan in the distal part of the rat's hind leg after both the intramuscular and percutaneous administration." | 3.69 | The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation. ( Bartácková, M; Blazek, K; Hulínská, D; Otová, B; Schramlová, J, 1997) |
| " These models of acute and chronic inflammation, and the antimitotic model permitted us to evaluate the anti-inflammatory and antimitotic effects of sulindac, ibuprofen, naproxen and glucametacin." | 3.69 | Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. ( Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM, 1996) |
| " Several members of this family were found to be potent, dual inhibitors of cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism and to have in vivo antiinflammatory activity in the rat foot edema assay." | 3.68 | 1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity. ( Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ, 1990) |
| " In rat adjuvant arthritis, NS-398 showed a therapeutic effect comparable to that seen with loxoprofen but less than that seen with indomethacin and diclofenac." | 3.68 | NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993) |
| "Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage." | 3.68 | Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac. ( Blower, PR; Gentry, C; Melarange, R; O'Connell, C, 1991) |
| "Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay in rats than currently marketed nonsteroidal antiinflammatory drugs." | 3.67 | Bulky amine analogues of ketoprofen: potent antiinflammatory agents. ( Behn, DC; Botton, I; Fellows, CA; Laskowski, SC; Phillips, DK; Schlegel, DC; Speight, PT; Zenitz, BL, 1984) |
| "The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated." | 3.67 | Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986) |
| "We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor." | 3.67 | Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987) |
| " Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents." | 3.66 | [Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981) |
| "Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0." | 3.30 | Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. ( Abusamak, M; García-Denche, JT; Marino, FAT; Pérez-González, F; Sáez-Alcaide, LM, 2023) |
| "The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening." | 2.77 | Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. ( Aznar-Arasa, L; Figueiredo, R; Gay-Escoda, C; Harutunian, K; Valmaseda-Castellón, E, 2012) |
| "Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery." | 2.75 | Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. ( Morkel, JA; Siddiqi, A; Zafar, S, 2010) |
| " Mild-to-moderate adverse effects were reported." | 2.74 | A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. ( Chopra, D; Kakkar, AK; Mehra, P; Rehan, HS, 2009) |
| "The profiles of postoperative pain in the two groups were similar from the first postoperative day, but Ibumetin was better pain reliever on the day of surgery." | 2.67 | Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon). ( Anzén, B; Lysell, L, 1992) |
| "Trismus was significantly reduced in the He-Ne laser and ibuprofen treatment groups." | 2.67 | A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars. ( Barberia, E; Calatayud, J; Carrillo, JS; Donado, M; Manso, FJ; Martinez, JM, 1990) |
| "Nabumetone is an appropriate choice of nonsteroidal anti-inflammatory drug for the treatment of sports injury." | 2.66 | Nabumetone in the treatment of skin and soft tissue injury. ( Jenner, PN, 1987) |
| "Bilateral leg edema is a frequent symptom in older people and an important concern in geriatric medicine." | 2.52 | Bilateral leg edema in an older woman. ( Pienaar, S; Roller-Wirnsberger, RE; Thaler, HW; Wirnsberger, G, 2015) |
| "Ibuprofen 600 mg was very effective in controlling inflammatory pain after lower third molar surgeries, without relevant adverse reactions; although in a very subtle way, patients with poor metabolism had higher levels of pain in the first hours, and no longer after 8 h, and used pain relief medication earlier." | 1.62 | CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction. ( Absher, DM; Bonjardim, LR; Calvo, AM; Colombini-Ishiquiriama, BL; Costa, YM; Dionísio, TJ; Moore, T; Oliveira, GM; Santos, CF; Torres, EA; Weckwerth, GM, 2021) |
| "Paw edema was analyzed using a plethysmometer." | 1.48 | Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats. ( Casarin, RCV; Casati, MZ; Cirano, FR; Corrêa, MG; Napimoga, MH; Pimentel, SP; Pires, PR; Ribeiro, FV, 2018) |
| "Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation." | 1.43 | Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity. ( Bajpai, M; Gaur, PK; Mishra, S; Verma, A, 2016) |
| "Inflammatory and pain are major areas for drug discovery." | 1.42 | Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen. ( Dai, D; Deng, X; Huang, W; Lin, H; Qian, H; Qiu, Q; Wang, J, 2015) |
| "The edema was produced in a dose- and time-dependent manner." | 1.39 | Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013) |
| "Acute calcific tendinitis is an important consideration in the differential diagnosis of acute wrist pain." | 1.39 | Acute calcific tendinitis of the wrist. ( Bral, D; Geiderman, JM; Torbati, SS, 2013) |
| " Pretreatment of carrageenan-induced hyperalgesic animals with UP446 at 150 mg/kg oral dosage reduced the hypersensitivity of pain by 39." | 1.38 | Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012) |
| "Paw volume, thermal hyperalgesia, mechanical allodynia, joint stiffness and mobility behaviors (score) were measured." | 1.37 | Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. ( Bijjem, KR; Kaur, S; Sharma, PL, 2011) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| "Pain, swelling and trismus were the commonest complaints." | 1.31 | Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria. ( Assam, E; Oginni, FO; Ogunbodede, EO; Ugboko, VI, 2002) |
| "When colchicine was administered after intradermal FMLP, subsequent plasma leakage was abolished." | 1.28 | Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin. ( Hellewell, PG; Williams, TJ; Yarwood, H, 1989) |
| "Standard burns were sequentially produced on the backs of Sprague-Dawley rats at 0, 1, 2, and 2 1/2 hr, followed by the IV injection of Evans blue dye." | 1.27 | Arachidonic acid metabolites mediate early burn edema. ( Alexander, F; Hechtman, HB; Huval, WV; Lelcuk, S; Mathieson, M; Shepro, D; Teoh, KH; Valeri, CR, 1984) |
| "Ibuprofen-treated animals did not exhibit any PMN influx into the lung." | 1.27 | Role of polymorphonuclear leukocytes in hyperoxic lung injury. Prevention of neutrophil influx into the lung endothelium during oxygen exposure by ibuprofen. ( Bandyopadhyay, D; Das, DK; Hoory, S; Steinberg, H, 1988) |
| "Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid." | 1.26 | Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. ( Aparicio, L, 1977) |
| " The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis; in this system, both compounds were active when dosed intraperitoneally but failed to produce significant activity when dosed orally at subtoxic doses." | 1.26 | Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues. ( Millonig, RC; Rovnyak, GC; Schwartz, J; Shu, V, 1982) |
Research
Studies (179)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (16.76) | 18.7374 |
| 1990's | 20 (11.17) | 18.2507 |
| 2000's | 56 (31.28) | 29.6817 |
| 2010's | 57 (31.84) | 24.3611 |
| 2020's | 16 (8.94) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Clark, RL | 1 |
| Pessolano, AA | 1 |
| Witzel, B | 1 |
| Lanza, T | 1 |
| Shen, TY | 1 |
| Van Arman, CG | 1 |
| Risley, EA | 1 |
| Sprague, PW | 1 |
| Heikes, JE | 1 |
| Tamura, Y | 1 |
| Yoshimoto, Y | 1 |
| Kunimoto, K | 1 |
| Tada, S | 1 |
| Tomita, T | 1 |
| Chawla, AS | 1 |
| Sharma, AK | 3 |
| Handa, SS | 1 |
| Dhar, KL | 1 |
| Musser, JH | 1 |
| Kreft, AF | 1 |
| Bender, RH | 1 |
| Kubrak, DM | 1 |
| Grimes, D | 1 |
| Carlson, RP | 1 |
| Hand, JM | 1 |
| Chang, J | 1 |
| Mylari, BL | 1 |
| Carty, TJ | 1 |
| Moore, PF | 1 |
| Zembrowski, WJ | 1 |
| Lazer, ES | 1 |
| Matteo, MR | 1 |
| Possanza, GJ | 1 |
| Rovnyak, GC | 1 |
| Millonig, RC | 2 |
| Schwartz, J | 1 |
| Shu, V | 1 |
| Wade, PC | 1 |
| Vogt, BR | 1 |
| Kissick, TP | 1 |
| Simpkins, LM | 1 |
| Palmer, DM | 1 |
| Schlegel, DC | 1 |
| Zenitz, BL | 1 |
| Fellows, CA | 1 |
| Laskowski, SC | 1 |
| Behn, DC | 1 |
| Phillips, DK | 1 |
| Botton, I | 1 |
| Speight, PT | 1 |
| Boettcher, I | 1 |
| Elger, W | 1 |
| Kirsch, G | 1 |
| Siegmund, F | 1 |
| Wachtel, H | 1 |
| Hino, K | 1 |
| Nakamura, H | 1 |
| Nagai, Y | 1 |
| Uno, H | 1 |
| Nishimura, H | 1 |
| Janusz, JM | 3 |
| Young, PA | 3 |
| Ridgeway, JM | 2 |
| Scherz, MW | 3 |
| Enzweiler, K | 3 |
| Wu, LI | 3 |
| Gan, L | 3 |
| Darolia, R | 1 |
| Matthews, RS | 1 |
| Hennes, D | 1 |
| Kellstein, DE | 3 |
| Green, SA | 3 |
| Tulich, JL | 3 |
| Rosario-Jansen, T | 3 |
| Magrisso, IJ | 3 |
| Wehmeyer, KR | 3 |
| Kuhlenbeck, DL | 3 |
| Eichhold, TH | 3 |
| Dobson, RL | 3 |
| Sirko, SP | 1 |
| Farmer, RW | 1 |
| Pikul, S | 1 |
| McDow-Dunham, KL | 1 |
| Johnson, CR | 1 |
| Senanayake, CB | 1 |
| Chen, J | 2 |
| Habeeb, AG | 2 |
| Praveen Rao, PN | 2 |
| Knaus, EE | 6 |
| Lolli, ML | 1 |
| Cena, C | 1 |
| Medana, C | 1 |
| Lazzarato, L | 1 |
| Morini, G | 2 |
| Coruzzi, G | 1 |
| Manarini, S | 1 |
| Fruttero, R | 1 |
| Gasco, A | 1 |
| Amini, M | 1 |
| Li, H | 1 |
| Rao, PN | 1 |
| Uddin, MJ | 1 |
| Dassonville, A | 1 |
| Bretéché, A | 1 |
| Evano, J | 1 |
| Duflos, M | 1 |
| le Baut, G | 1 |
| Grimaud, N | 1 |
| Petit, JY | 1 |
| Molvi, KI | 1 |
| Vasu, KK | 4 |
| Yerande, SG | 1 |
| Sudarsanam, V | 4 |
| Haque, N | 1 |
| Sondhi, SM | 2 |
| Jain, S | 3 |
| Dinodia, M | 1 |
| Shukla, R | 2 |
| Raghubir, R | 1 |
| Franklin, PX | 1 |
| Pillai, AD | 2 |
| Rathod, PD | 2 |
| Yerande, S | 1 |
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Clinical Trials (8)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Pharmacogenetic of Ibuprofen Enantiomers After Lower Third Molar Surgeries[NCT03169127] | Phase 4 | 200 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| Effect on Initial Endodontic Treatment on Postoperative Pain in Symptomatic Teeth With Pulpal Necrosis[NCT01870973] | 108 participants (Actual) | Interventional | 2013-03-31 | Completed | |||
| Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes[NCT00567528] | 60 participants (Actual) | Interventional | 2006-05-31 | Terminated (stopped due to Study was not producing meaningful data.) | |||
| A Randomized, Double-Blind, Parallel-Group Study Comparing the Safety and Effectiveness of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Ankle Sprains.[NCT00261560] | Phase 4 | 260 participants (Actual) | Interventional | Completed | |||
| Evaluation of Postoperative Edema and Pain Following Third Molar Extraction With Application of Pulsed Electromagnetic Field (PEMF) Therapy[NCT02376946] | 49 participants (Actual) | Interventional | 2014-01-31 | Terminated (stopped due to Sponsor decision) | |||
| Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling[NCT00805298] | 154 participants (Actual) | Interventional | 2008-08-31 | Completed | |||
| Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial.[NCT03033147] | 72 participants (Actual) | Interventional | 2019-10-18 | Completed | |||
| Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial[NCT03007342] | 78 participants (Anticipated) | Interventional | 2017-01-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use
"pain measurement as assessed on a visual analog scale and pain medication usage~definition of success = no or mild pain as analyzed on VAS scale and no narcotic use; analyzed by logistic regression~VAS scale is 0 to 170 mm with the higher numbers indicating more pain and less success." (NCT01870973)
Timeframe: each day for 5 days
| Intervention | percentage of participants (Number) |
|---|---|
| Root Canal Treatment | 52 |
| no Root Canal Treatment | 43 |
Reviews
2 reviews available for ibuprofen and Edema
| Article | Year |
|---|---|
Bilateral leg edema in an older woman.
Topics: Aged, 80 and over; Chronic Disease; Diagnosis, Differential; Edema; Female; Heart Diseases; Humans; | 2015 |
Red ear syndrome: case report and review of the literature.
Topics: Adult; Analgesics, Non-Narcotic; Ear Diseases; Edema; Erythema; Female; Humans; Hyperhidrosis; Ibupr | 2011 |
Trials
21 trials available for ibuprofen and Edema
| Article | Year |
|---|---|
Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial.
Topics: Cross-Over Studies; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative | 2023 |
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post | 2021 |
Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial.
Topics: Analgesia; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative; Tooth E | 2021 |
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible; | 2016 |
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory | 2009 |
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacterial Agen | 2010 |
Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial.
Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female; | 2012 |
The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans.
Topics: Analgesics, Non-Narcotic; Chronic Periodontitis; Color; Combined Modality Therapy; Edema; Female; Hu | 2013 |
Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-St | 2002 |
A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies | 2003 |
Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.
Topics: Acid-Base Equilibrium; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2006 |
Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Injuries; Arthralgia; Contusions; Double-Blind Method | 2006 |
Ibuprofen and compression bandage in the treatment of ankle sprains.
Topics: Adult; Ankle Injuries; Bandages; Clinical Trials as Topic; Edema; Female; Humans; Ibuprofen; Male; P | 1983 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen; | 1995 |
Effect of apical trephination on postoperative pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anti-Infla | 2001 |
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varianc | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla | 2001 |
Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.
Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Edema; Female; Hemostasis; Humans; Ibu | 1975 |
Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon).
Topics: Acetaminophen; Adolescent; Adult; Codeine; Drug Combinations; Edema; Female; Humans; Ibuprofen; Male | 1992 |
A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars.
Topics: Adult; Double-Blind Method; Edema; Female; Humans; Ibuprofen; Laser Therapy; Male; Molar, Third; Pai | 1990 |
Nabumetone in the treatment of skin and soft tissue injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butano | 1987 |
Other Studies
156 other studies available for ibuprofen and Edema
| Article | Year |
|---|---|
2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1978 |
Synthesis and antiinflammatory activity of cis-4,5,6,7,8,8a,9-hexahydro-alpha-methyl-5H-fluorene-2-acetic acid.
Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Edema; Fluorenes; Magnetic Resonance Spectroscop | 1977 |
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compo | 1977 |
Chemical investigation and anti-inflammatory activity of Vitex negundo seeds.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chloroform; Edema; Foot; India; Male; | 1992 |
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
Topics: Animals; Azoles; Benzamides; Biological Assay; Bronchial Spasm; Carrageenan; Chemical Phenomena; Che | 1990 |
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arac | 1990 |
Benzimidazole derivatives with atypical antiinflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Benzimidazoles | 1987 |
Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Che | 1982 |
1-Acyltriazoles as antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Edema; Ibuprofen; Male; | 1982 |
Bulky amine analogues of ketoprofen: potent antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chemical Phenomena; Chemistry; Drug Eval | 1984 |
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; M | 1984 |
Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carboxylic Acids; Carrageenan; Edema; Fe | 1983 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.
Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Blood Platelets; Carrageenan; Cyclooxygenase Inhibit | 1998 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzofurans; Blood Platelets; Carrageenan; Cyclooxyge | 1998 |
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Cyclooxygena | 1998 |
Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.
Topics: Abdominal Muscles; Androstenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cycl | 2001 |
A new class of ibuprofen derivatives with reduced gastrotoxicity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic N-Oxides; Edema; Gastric Mucos | 2001 |
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; | 2003 |
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Isoenzymes; Membrane Pr | 2004 |
New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors.
Topics: Administration, Cutaneous; Administration, Oral; Amides; Animals; Anti-Inflammatory Agents, Non-Ster | 2004 |
Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2007 |
One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageen | 2007 |
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhib | 2008 |
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
Topics: Animals; Anti-Inflammatory Agents; Benzene; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhib | 2007 |
Synthesis, pharmacological activity and hydrolytic behavior of ethylenediamine and benzathine conjugates of ibuprofen.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dis | 2008 |
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.
Topics: Acetylene; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Chemistry, Pharmaceutical | 2008 |
Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities.
Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclizatio | 2009 |
Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Furans; Li | 2009 |
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Molecular Structure; Oxadi | 2009 |
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch | 2009 |
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
Topics: Animals; Anti-Inflammatory Agents; Azo Compounds; Cyclooxygenase Inhibitors; Edema; Foot; Humans; Ni | 2009 |
Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives.
Topics: Acridines; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor; | 2010 |
Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carrageenan; Drug Design; E | 2010 |
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Est | 2011 |
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell S | 2011 |
New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus subtilis; Carragee | 2011 |
Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Pyrazoles; Rats | 2011 |
Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Coumarins; Edema; Microsomes; Rats | 2011 |
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase 1; Cyclooxy | 2012 |
Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Ibupr | 2012 |
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzothiazoles; Click Chemistry; Cyclooxygenase Inhib | 2012 |
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Catalytic Domain; Com | 2012 |
Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cell Proliferation; Crystallography, X-Ray | 2012 |
Synthesis and evaluation of mutual prodrugs of ibuprofen with menthol, thymol and eugenol.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Eugenol; Female; Hydrogen-Ion | 2012 |
A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones.
Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dos | 2013 |
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthons.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C | 2015 |
2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Edema; Flavanones; Inflammation | 2015 |
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma | 2015 |
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype | 2016 |
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Anim | 2016 |
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.
Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Carrageenan; Chemical and D | 2017 |
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Benzoxazoles; Binding Sites; Catalytic Domain; Cattle; Cyclooxyge | 2018 |
Synthesis and biological properties of aryl methyl sulfones.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet | 2018 |
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cattle; Cyclooxygenase 1; Cyclooxy | 2020 |
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An | 2020 |
In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae).
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2022 |
Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol.
Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan | 2022 |
New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2023 |
Anti-rheumatic activity of Phenethyl isothiocyanate via inhibition of histone deacetylase-1.
Topics: Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumat | 2020 |
Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygena | 2020 |
CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Cytochrome P-450 CYP2C8 | 2021 |
Evaluation and comparison of anti-inflammatory properties of ibuprofen using two drug delivery systems after third molar surgery: using chitosan microspheres as a carrier for local drug delivery in to the third molar socket and through the oral route.
Topics: Anti-Inflammatory Agents; Chitosan; Drug Delivery Systems; Edema; Humans; Ibuprofen; Mandible; Micro | 2021 |
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Surviva | 2021 |
Young child with painful edema and purpura: a case report.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Hemorrhage; | 2021 |
The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of
Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Diclofenac; Edema; | 2021 |
Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen | 2022 |
Hypersensitivity Reaction to Yellow Jacket Sting in a Previously Nonallergic Patient Taking an Angiotensin Receptor Blocker.
Topics: Aged; Angiotensin Receptor Antagonists; Animals; Anti-Allergic Agents; Diphenhydramine; Edema; Human | 2017 |
Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Carrageenan; Edema; Gastric Mucosa; | 2017 |
Synergistic analgesic, anti-pyretic and anti-inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice.
Topics: Acetic Acid; Albinism; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Din | 2017 |
Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Benzimidazoles; Carrageenan; Disease | 2018 |
Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Benzamides; Benzoxazoles; Carrageenan; Cyclooxygenase 1; Cyclooxy | 2018 |
Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice.
Topics: Animals; Butylscopolammonium Bromide; Disease Models, Animal; Dysmenorrhea; Edema; Euphorbia; Female | 2019 |
Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Dis | 2018 |
Similar pain, swelling, and trismus after third-molar surgical extraction when receiving a phytotherapeutic drug, ibuprofen, or a placebo.
Topics: Edema; Humans; Ibuprofen; Molar; Molar, Third; Pain; Plant Extracts; Tooth Extraction; Tooth, Impact | 2019 |
Formulation of topical ibuprofen solid lipid nanoparticle (SLN) gel using hot melt extrusion technique (HME) and determining its anti-inflammatory strength.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Lib | 2019 |
Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs.
Topics: 1-Octanol; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car | 2014 |
Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase 1; Cy | 2015 |
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, A | 2014 |
Mechanical properties, skin permeation and in vivo evaluations of dexibuprofen-loaded emulsion gel for topical delivery.
Topics: Adhesiveness; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Deli | 2015 |
Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity.
Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under C | 2016 |
Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparat | 2015 |
Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I | 2016 |
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; | 2016 |
Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block.
Topics: Acetaminophen; Acetazolamide; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents | 2008 |
Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of ibuprofen derivatives.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Gastric Mu | 2007 |
Periorbital edema associated with separate courses of ibuprofen and naproxen.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Edema; Eye Diseases; Female; Humans; Ibu | 2010 |
Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose | 2011 |
ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
Topics: Activating Transcription Factor 6; Adjuvants, Immunologic; Animals; Anthraquinones; Anti-Inflammator | 2012 |
In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.
Topics: Acetic Acid; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceuti | 2011 |
Biological activity of some derivatives of β-cyclodextrin.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; beta-Cyclodextrins; Edema; Ibuprofen; Mice; Molecular St | 2011 |
TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.
Topics: Acetanilides; Animals; Carrageenan; Edema; HEK293 Cells; Humans; Ibuprofen; Mice; Mice, Inbred C57BL | 2012 |
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Carriers; Edema; Ibup | 2012 |
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi | 2012 |
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For | 2012 |
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil | 2013 |
Acute calcific tendinitis of the wrist.
Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Calcinosis; Chills; Edema | 2013 |
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I | 2002 |
Effect of drainage upon access on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2002 |
Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Edema; Female; Humans; Ibuprofen; Male; | 2002 |
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Carrageenan; Dime | 2003 |
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Eating; Edema; Estradiol; | 2003 |
Painful, swollen lower legs.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Erythema Nodosum; Fe | 2003 |
Anti-inflammatory action of sulfoaryl 3,3-disubstituted triazenes in rat experimental edema models.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bentonite; Carrageenan; Chemical Phenomen | 2003 |
Synthesis and analgesic-anti-inflammatory activities of some 1,2,4-triazine derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Ibuprofen; Indicators and Reag | 2004 |
Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; | 2004 |
Localized periorbital edema induced by Ibuprofen.
Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Follow-Up Stud | 2005 |
Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Edema; Female | 2006 |
Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carrageenan; Chemical Phenomena; Chemis | 2006 |
New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Carrageenan; Cell Survival; Dis | 2006 |
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High | 2006 |
Nitrooxyethylation reverses the healing-suppressant effect of Ibuprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Collagen; Edema; Granulation Tissue; Ibu | 2006 |
Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotherapy, Adjuvant; Edema; Female; Granuloma; | 2006 |
57-year-old Asian-American man with Kikuchi's disease.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Asian; Biopsy; Diagno | 2006 |
Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.
Topics: Administration, Topical; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; | 2007 |
Synthesis and evaluation of the antiinflammatory activity of N-[2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-nicotinamide.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Exp | 2007 |
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
Topics: Acetone; Administration, Cutaneous; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroi | 2007 |
Arachidonic acid metabolites mediate early burn edema.
Topics: Animals; Body Water; Burns; Calcium Channel Blockers; Capillary Permeability; Chromones; Edema; Ibup | 1984 |
Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs.
Topics: Aminophylline; Animals; Anti-Inflammatory Agents; Arthus Reaction; Colchicine; Edema; Guinea Pigs; H | 1984 |
[Pharmacologic profile of a new compound with antiinflammatory activity: 2-(4-dimethylvinylphenyl)propionic acid (Gx 258)].
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1984 |
[Pharmacologic-toxicologic study of an ibuprofen-containing creme].
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Erythema; Female; Gr | 1983 |
Additional pharmacological studies on ibuprofen guaiacol ester (AF 2259).
Topics: Analgesics; Animals; Antitussive Agents; Edema; Female; Guaiacol; Guinea Pigs; Ibuprofen; Male; Mice | 1983 |
A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Digestive System; Edema; Female; | 1980 |
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero | 1981 |
Elevated levels of TNF in the joints of adjuvant arthritic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Assay; Cells, | 1993 |
Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin.
Topics: Acute Disease; Alprostadil; Animals; Arginine; Dermatitis; Edema; Female; Guinea Pigs; Ibuprofen; Le | 1993 |
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena | 1993 |
Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dioxins; Edema; Foot; Ibuprofen; Male | 1996 |
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall; | 1996 |
Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Ar | 1998 |
The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Connective | 1997 |
Ibuprofen modulates tissue perfusion in partial-thickness burns.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Burns; Ear, | 2000 |
Antinociceptive and anti-oedematogenic properties of astilbin, taxifolin and some related compounds.
Topics: Acetaminophen; Acetates; Analgesics; Analgesics, Non-Narcotic; Animals; Aspirin; Edema; Flavonoids; | 2000 |
Synthesis and characterization of a diruthenium-ibuprofenato complex comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Gastrointestinal Hemorrhage; I | 2000 |
Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation.
Topics: Administration, Topical; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2000 |
Activity profile of glycolamide ester prodrugs of ibuprofen.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Esters; | 2001 |
Anti-inflammatory activity of (+)-usnic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Dose-Response Relationsh | 2000 |
Alkyl ester prodrugs for improved topical delivery of ibuprofen.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Ibuprofen; Prodrug | 2001 |
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinic | 2002 |
Kinetics and hydrolysis mechanism of polymeric prodrugs containing ibuprofen, ketoprofen, and naproxen as pendent agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Stability; Edema; Female; Hydrogen-Ion Concen | 2002 |
Ibuprofen in the treatment of macular edema and central serous chorioretinopathy.
Topics: Choroid; Edema; Humans; Ibuprofen; Macula Lutea; Retinal Diseases; Uveal Diseases | 1979 |
Edema associated with ibuprofen therapy.
Topics: Aged; Diuresis; Edema; Humans; Ibuprofen; Male; Pain; Phenylpropionates | 1977 |
Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Gr | 1977 |
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen | 1976 |
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu | 1975 |
4-(1,2-Benzisothiazol-3-yl)alkanoic and phenylalkanoic acids: synthesis and anti-inflammatory, analgesic and antipyretic activities.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Escherichia coli; Ibuprofen; M | 1992 |
Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carrageenan; Diclofenac; E | 1991 |
[Effects of alminoprofen on the allergic reactions].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bronchoconstriction; | 1990 |
Early postburn lipid peroxidation: effect of ibuprofen and allopurinol.
Topics: Allopurinol; Animals; Burns; Disease Models, Animal; Edema; Ibuprofen; Inflammation; Lipid Peroxidat | 1990 |
Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Colchicine; Dinoprostone; Edema; Endotoxin | 1989 |
Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage.
Topics: 4-Butyrolactone; Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 1986 |
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition.
Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Ibuprofen; Imidazoles; Indomethac | 1986 |
Role of polymorphonuclear leukocytes in hyperoxic lung injury. Prevention of neutrophil influx into the lung endothelium during oxygen exposure by ibuprofen.
Topics: Animals; Cell Survival; Chemotaxis, Leukocyte; Edema; Ibuprofen; Indium Radioisotopes; Lung; Neutrop | 1988 |
Topical ibuprofen decreases early postburn edema.
Topics: 6-Ketoprostaglandin F1 alpha; Administration, Topical; Animals; Burns; Edema; Ibuprofen; Lymph; Pros | 1987 |
[Synthesis and preliminary pharmacological studies of new derivatives of 2-(4-isobutylphenyl)propionic acid (brufen)].
Topics: Animals; Drug Evaluation, Preclinical; Edema; Ibuprofen; Male; Mice; Mice, Inbred Strains; Rats; Rat | 1985 |