Page last updated: 2024-10-28

ibuprofen and Edema

ibuprofen has been researched along with Edema in 179 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.

Research Excerpts

ExcerptRelevanceReference
" However, etodolac use showed better results regarding pain, trismus and edema."9.41The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021)
"To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars."9.22Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016)
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains."9.12Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006)
"We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen."7.78ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012)
"A case of periorbital edema associated with separate courses of ibuprofen and naproxen is reported."7.76Periorbital edema associated with separate courses of ibuprofen and naproxen. ( Balas, M; Plakogiannis, R; Sinnett, M, 2010)
"PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment."7.74Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. ( Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J, 2007)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."7.73Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
" Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability."7.71A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002)
"Ibuprofen increases tissue perfusion and reduces edema formation in scald burned rabbit ears."7.70Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000)
"The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated."7.67Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986)
"We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor."7.67Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987)
"Paw edema was analyzed using a plethysmometer."5.48Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats. ( Casarin, RCV; Casati, MZ; Cirano, FR; Corrêa, MG; Napimoga, MH; Pimentel, SP; Pires, PR; Ribeiro, FV, 2018)
" However, etodolac use showed better results regarding pain, trismus and edema."5.41The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021)
"This randomized controlled clinical trial aimed to evaluate the preemptive effects of acetaminophen, ibuprofen, ketoprofen, nimesulide or dexamethasone on postoperative pain and edema in the surgical removal of impacted third molars."5.41Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial. ( Araújo, AVA; Costa, FO; Cota, LOM; Cyrino, RM; Pinto Júnior, AAC; Santos, BFE, 2021)
"To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars."5.22Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016)
"To compare acetaminophen extended release 1,300 mg 3 times daily and ibuprofen 400 mg 3 times daily for treatment of signs and symptoms of grade I or II lateral ankle sprains."5.12Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. ( Dalton, JD; Schweinle, JE, 2006)
"The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) and rheumatoid arthritis (RA) patients."5.12Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. ( Lefkowith, JL; Verburg, KM; West, CR; Whelton, A, 2006)
" Further, 11-14 demonstrated comparable anti-inflammatory activity with ibuprofen in carrageenan-induced rat paw edema assay and appreciable inhibition of lipopolysaccharide (LPS) induced pro-inflammatory mediators (TNF-α and IL-1β) in Sprague Dawley (SD) rats."3.812'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies. ( Bairwa, K; Bhutani, KK; Gangwal, R; Jachak, SM; Jaiswal, G; Patel, NK; Sangamwar, AT, 2015)
"9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy."3.80S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014)
"We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen."3.78ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012)
"A new series of 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives were synthesized and investigated their anti-inflammatory activities using carrageenan-induced rat paw edema model in vivo."3.77Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives. ( Bantu, R; Gaikwad, HK; Mateti, J; Nagarapu, L; Prameela Subhashini, NJ; Sheeba Rani, M, 2011)
"A case of periorbital edema associated with separate courses of ibuprofen and naproxen is reported."3.76Periorbital edema associated with separate courses of ibuprofen and naproxen. ( Balas, M; Plakogiannis, R; Sinnett, M, 2010)
"A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body weight."3.74Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. ( Haque, N; Molvi, KI; Sudarsanam, V; Vasu, KK; Yerande, SG, 2007)
"Substituted thiazoles with different structural features were synthesized and screened for their anti-inflammatory activity in acute carrageenin induced rat paw edema model and chronic formalin induced rat paw edema model."3.742-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures. ( Franklin, PX; Nivsarkar, M; Padh, H; Pillai, AD; Rathod, PD; Sudarsanam, V; Vasu, KK; Yerande, S, 2008)
" Several derivatives, including (S)-2, 14 and 17, showed more anti-inflammatory activity in vivo in these assays (rat paw oedema induced by carrageenan) than the known classical anti-inflammatory agent ibuprofen, whereas other compounds like 1 were equipotent to ibuprofen."3.74Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system. ( Daidone, G; Harrak, Y; Plescia, S; Pujol, MD; Rosell, G; Schillaci, D, 2007)
"PMA exerted potentiating action on contralateral acetone-induced ear oedema, which was inhibited by ibuprofen, topical capsaicin desensitization of the acetone-treated ear as well as by systemic RTX pretreatment."3.74Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice. ( Brain, SD; Helyes, Z; Perkecz, A; Pintér, E; Pozsgai, G; Sándor, K; Szolcsányi, J, 2007)
"We documented localized periorbital edema in one patient with ibuprofen sensitivity without underlying chronic urticaria."3.73Localized periorbital edema induced by Ibuprofen. ( Ogawa, H; Palungwachira, P, 2005)
"The sub-effective dose of VN potentiated anti-inflammatory activity of phenlbutazone and ibuprofen significantly in carrageenin induced hind paw oedema and cotton pellet granuloma models."3.73Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs. ( Gupta, RK; Tandon, VR, 2006)
"0032 muM) and COX-2 selectivity (SI > 120 000), 14s exhibited moderate antiinflammatory activity compared to celecoxib in a carrageenan-induced rat paw edema assay."3.72Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. ( Amini, M; Habeeb, AG; Knaus, EE; Li, H; Praveen Rao, PN, 2003)
" Pretreatment with p-chlorophenylalanine, indomethacin, ibuprofen, and nimodipine attenuated the SCEP changes immediately after trauma and resulted in a marked reduction in edema formation, BSCB permeability, and blood flow changes at 5 h."3.71Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat. ( Sharma, HS; Winkler, T, 2002)
" Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability."3.71A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002)
"Ibuprofen increases tissue perfusion and reduces edema formation in scald burned rabbit ears."3.70Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000)
" Intraplantar injection of arachidonic acid (AA) into the rat paw was followed by a rapid and sustained (> or = 4h) inflammatory oedema."3.70Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat. ( Angel, I; Arbilla, S; Pichat, P, 1998)
" The 2-(2,3-dihydro-1, 4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay."3.69Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids. ( Pujol, MD; Rosell, G; Vázquez, MT, 1996)
"The antiphlogistic Ibuprofen incorporated in liposomes caused a decrease of the inflammatory edema induced by Carrageenan in the distal part of the rat's hind leg after both the intramuscular and percutaneous administration."3.69The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation. ( Bartácková, M; Blazek, K; Hulínská, D; Otová, B; Schramlová, J, 1997)
" These models of acute and chronic inflammation, and the antimitotic model permitted us to evaluate the anti-inflammatory and antimitotic effects of sulindac, ibuprofen, naproxen and glucametacin."3.69Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque. ( Akatsu, T; Consolaro, A; Guimarães, SA; Tago, EM, 1996)
" Several members of this family were found to be potent, dual inhibitors of cyclooxygenase and 5-lipoxygenase pathways of arachidonic acid metabolism and to have in vivo antiinflammatory activity in the rat foot edema assay."3.681,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity. ( Carty, TJ; Moore, PF; Mylari, BL; Zembrowski, WJ, 1990)
" In rat adjuvant arthritis, NS-398 showed a therapeutic effect comparable to that seen with loxoprofen but less than that seen with indomethacin and diclofenac."3.68NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. ( Arai, I; Futaki, N; Hamasaka, Y; Higuchi, S; Iizuka, H; Otomo, S; Yoshikawa, K, 1993)
"Repeat oral dosing of nabumetone for 1 month maintains anti-inflammatory efficacy in a carrageenan model of paw oedema yet does not cause gastrointestinal damage."3.68Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac. ( Blower, PR; Gentry, C; Melarange, R; O'Connell, C, 1991)
"Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay in rats than currently marketed nonsteroidal antiinflammatory drugs."3.67Bulky amine analogues of ketoprofen: potent antiinflammatory agents. ( Behn, DC; Botton, I; Fellows, CA; Laskowski, SC; Phillips, DK; Schlegel, DC; Speight, PT; Zenitz, BL, 1984)
"The effects of a non-steroidal anti-inflammatory compound, ibuprofen, on experimentally-induced local oedema responses in rabbit skin were investigated."3.67Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition. ( Rampart, M; Williams, TJ, 1986)
"We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor."3.67Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987)
" Carbon tetrachloride (1,0 ml/Kg, os) is able in depressing significantly the rat paw oedema provoked by carrageenan, but does not potentiates the anti-inflammatory action of non-steroid agents."3.66[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents]. ( Curzio, M; Negro, F; Paradisi, L; Parola, M; Torrielli, MV, 1981)
"Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0."3.30Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial. ( Abusamak, M; García-Denche, JT; Marino, FAT; Pérez-González, F; Sáez-Alcaide, LM, 2023)
"The facial swelling and trismus were evaluated by measuring facial reference distances and maximum mouth opening."2.77Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial. ( Aznar-Arasa, L; Figueiredo, R; Gay-Escoda, C; Harutunian, K; Valmaseda-Castellón, E, 2012)
"Pain, swelling, infection, trismus and temperature were recorded on days 3, 7 and 14 after surgery."2.75Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique. ( Morkel, JA; Siddiqi, A; Zafar, S, 2010)
" Mild-to-moderate adverse effects were reported."2.74A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model. ( Chopra, D; Kakkar, AK; Mehra, P; Rehan, HS, 2009)
"The profiles of postoperative pain in the two groups were similar from the first postoperative day, but Ibumetin was better pain reliever on the day of surgery."2.67Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon). ( Anzén, B; Lysell, L, 1992)
"Trismus was significantly reduced in the He-Ne laser and ibuprofen treatment groups."2.67A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars. ( Barberia, E; Calatayud, J; Carrillo, JS; Donado, M; Manso, FJ; Martinez, JM, 1990)
"Nabumetone is an appropriate choice of nonsteroidal anti-inflammatory drug for the treatment of sports injury."2.66Nabumetone in the treatment of skin and soft tissue injury. ( Jenner, PN, 1987)
"Bilateral leg edema is a frequent symptom in older people and an important concern in geriatric medicine."2.52Bilateral leg edema in an older woman. ( Pienaar, S; Roller-Wirnsberger, RE; Thaler, HW; Wirnsberger, G, 2015)
"Ibuprofen 600 mg was very effective in controlling inflammatory pain after lower third molar surgeries, without relevant adverse reactions; although in a very subtle way, patients with poor metabolism had higher levels of pain in the first hours, and no longer after 8 h, and used pain relief medication earlier."1.62CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction. ( Absher, DM; Bonjardim, LR; Calvo, AM; Colombini-Ishiquiriama, BL; Costa, YM; Dionísio, TJ; Moore, T; Oliveira, GM; Santos, CF; Torres, EA; Weckwerth, GM, 2021)
"Paw edema was analyzed using a plethysmometer."1.48Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats. ( Casarin, RCV; Casati, MZ; Cirano, FR; Corrêa, MG; Napimoga, MH; Pimentel, SP; Pires, PR; Ribeiro, FV, 2018)
"Ibuprofen is an established non-steroidal anti-inflammatory drug commonly used for general inflammation."1.43Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity. ( Bajpai, M; Gaur, PK; Mishra, S; Verma, A, 2016)
"Inflammatory and pain are major areas for drug discovery."1.42Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen. ( Dai, D; Deng, X; Huang, W; Lin, H; Qian, H; Qiu, Q; Wang, J, 2015)
"The edema was produced in a dose- and time-dependent manner."1.39Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms. ( Laraba-Djebari, F; Sebia-Amrane, F, 2013)
"Acute calcific tendinitis is an important consideration in the differential diagnosis of acute wrist pain."1.39Acute calcific tendinitis of the wrist. ( Bral, D; Geiderman, JM; Torbati, SS, 2013)
" Pretreatment of carrageenan-induced hyperalgesic animals with UP446 at 150 mg/kg oral dosage reduced the hypersensitivity of pain by 39."1.38Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012)
"Paw volume, thermal hyperalgesia, mechanical allodynia, joint stiffness and mobility behaviors (score) were measured."1.37Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. ( Bijjem, KR; Kaur, S; Sharma, PL, 2011)
"Hypertension was induced by DOCA-salt."1.35Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009)
"Pain, swelling and trismus were the commonest complaints."1.31Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria. ( Assam, E; Oginni, FO; Ogunbodede, EO; Ugboko, VI, 2002)
"When colchicine was administered after intradermal FMLP, subsequent plasma leakage was abolished."1.28Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin. ( Hellewell, PG; Williams, TJ; Yarwood, H, 1989)
"Standard burns were sequentially produced on the backs of Sprague-Dawley rats at 0, 1, 2, and 2 1/2 hr, followed by the IV injection of Evans blue dye."1.27Arachidonic acid metabolites mediate early burn edema. ( Alexander, F; Hechtman, HB; Huval, WV; Lelcuk, S; Mathieson, M; Shepro, D; Teoh, KH; Valeri, CR, 1984)
"Ibuprofen-treated animals did not exhibit any PMN influx into the lung."1.27Role of polymorphonuclear leukocytes in hyperoxic lung injury. Prevention of neutrophil influx into the lung endothelium during oxygen exposure by ibuprofen. ( Bandyopadhyay, D; Das, DK; Hoory, S; Steinberg, H, 1988)
"Butibufen was within the potency range of ibuprofen as an antipyretic and analgesic agent and greater than that of acetylsalicylic acid."1.26Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent. ( Aparicio, L, 1977)
" The compounds of most interest, 18 and 28, were further tested in a model of adjuvant-induced arthritis; in this system, both compounds were active when dosed intraperitoneally but failed to produce significant activity when dosed orally at subtoxic doses."1.26Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues. ( Millonig, RC; Rovnyak, GC; Schwartz, J; Shu, V, 1982)

Research

Studies (179)

TimeframeStudies, this research(%)All Research%
pre-199030 (16.76)18.7374
1990's20 (11.17)18.2507
2000's56 (31.28)29.6817
2010's57 (31.84)24.3611
2020's16 (8.94)2.80

Authors

AuthorsStudies
Clark, RL1
Pessolano, AA1
Witzel, B1
Lanza, T1
Shen, TY1
Van Arman, CG1
Risley, EA1
Sprague, PW1
Heikes, JE1
Tamura, Y1
Yoshimoto, Y1
Kunimoto, K1
Tada, S1
Tomita, T1
Chawla, AS1
Sharma, AK3
Handa, SS1
Dhar, KL1
Musser, JH1
Kreft, AF1
Bender, RH1
Kubrak, DM1
Grimes, D1
Carlson, RP1
Hand, JM1
Chang, J1
Mylari, BL1
Carty, TJ1
Moore, PF1
Zembrowski, WJ1
Lazer, ES1
Matteo, MR1
Possanza, GJ1
Rovnyak, GC1
Millonig, RC2
Schwartz, J1
Shu, V1
Wade, PC1
Vogt, BR1
Kissick, TP1
Simpkins, LM1
Palmer, DM1
Schlegel, DC1
Zenitz, BL1
Fellows, CA1
Laskowski, SC1
Behn, DC1
Phillips, DK1
Botton, I1
Speight, PT1
Boettcher, I1
Elger, W1
Kirsch, G1
Siegmund, F1
Wachtel, H1
Hino, K1
Nakamura, H1
Nagai, Y1
Uno, H1
Nishimura, H1
Janusz, JM3
Young, PA3
Ridgeway, JM2
Scherz, MW3
Enzweiler, K3
Wu, LI3
Gan, L3
Darolia, R1
Matthews, RS1
Hennes, D1
Kellstein, DE3
Green, SA3
Tulich, JL3
Rosario-Jansen, T3
Magrisso, IJ3
Wehmeyer, KR3
Kuhlenbeck, DL3
Eichhold, TH3
Dobson, RL3
Sirko, SP1
Farmer, RW1
Pikul, S1
McDow-Dunham, KL1
Johnson, CR1
Senanayake, CB1
Chen, J2
Habeeb, AG2
Praveen Rao, PN2
Knaus, EE6
Lolli, ML1
Cena, C1
Medana, C1
Lazzarato, L1
Morini, G2
Coruzzi, G1
Manarini, S1
Fruttero, R1
Gasco, A1
Amini, M1
Li, H1
Rao, PN1
Uddin, MJ1
Dassonville, A1
Bretéché, A1
Evano, J1
Duflos, M1
le Baut, G1
Grimaud, N1
Petit, JY1
Molvi, KI1
Vasu, KK4
Yerande, SG1
Sudarsanam, V4
Haque, N1
Sondhi, SM2
Jain, S3
Dinodia, M1
Shukla, R2
Raghubir, R1
Franklin, PX1
Pillai, AD2
Rathod, PD2
Yerande, S1
Nivsarkar, M1
Padh, H2
Harrak, Y1
Rosell, G3
Daidone, G1
Plescia, S1
Schillaci, D1
Pujol, MD3
Chatterjee, NR1
Kulkarni, AA1
Ghulekar, SP1
Chowdhury, MA3
Chen, H1
Abdellatif, KR4
Dong, Y2
Petruk, KC1
Akhter, M1
Husain, A2
Azad, B1
Ajmal, M1
Alam, MM2
Hasan, SM1
Anwer, T1
Chikhale, RV1
Bhole, RP1
Khedekar, PB1
Bhusari, KP1
Jayashankar, B1
Lokanath Rai, KM1
Baskaran, N1
Sathish, HS1
Sujith, KV1
Rao, JN1
Shetty, P1
Kalluraya, B1
Das, D1
Yu, G1
Velázquez, C1
Suresh, MR1
Singh, J1
Rani, R1
Gupta, PP1
Agrawal, SK1
Saxena, AK1
Giri, RS1
Thaker, HM1
Giordano, T1
Williams, J1
Rogers, D1
Huang, Z1
Velázquez, CA1
Reisz, JA1
DuMond, JF1
King, SB1
Liu, W1
Zhou, J1
Bensdorf, K1
Zhang, H1
Liu, H1
Wang, Y1
Qian, H2
Zhang, Y2
Wellner, A1
Rubner, G1
Huang, W2
Guo, C1
Gust, R1
Mohamed, MS1
Kamel, R1
Fatahala, SS1
Nagarapu, L1
Mateti, J1
Gaikwad, HK1
Bantu, R1
Sheeba Rani, M1
Prameela Subhashini, NJ1
Sashidhara, KV1
Kumar, M1
Modukuri, RK1
Sonkar, R1
Bhatia, G1
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Nagaraju, D2
Reddy, YN2
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Kourounakis, PN1
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Lee, WS1
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Chen, L1
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Kazkayası, I1
Okay, G1
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Yimam, M1
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Jia, Q1
Sebia-Amrane, F1
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Torbati, SS1
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Winkler, T1
Nusstein, JM1
Reader, A4
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Ugboko, VI1
Assam, E1
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Whitefield, M1
O'Kane, CJ1
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Holla, BS1
Malini, KV1
Rao, BS1
Sarojini, BK1
Kumari, NS1
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Haanaes, HR1
Skoglund, LA1
Kerins, CA1
Carlson, DS1
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Kazemekaite, M1
Talaikyte, Z1
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Palaima, A1
Makhlouf, AA1
Maklad, YA1
Xavier, FP1
Palungwachira, P2
Ogawa, H1
Zhao, X1
Tao, X1
Wei, D1
Song, Q1
Peng, YS1
Lin, SC1
Huang, SJ1
Wang, YM1
Lin, YJ1
Wang, LF2
Chen, JS1
Regiec, A1
Machoń, Z1
Miedzybrodzki, R1
Szymaniec, S1
Whelton, A1
Lefkowith, JL1
West, CR1
Verburg, KM1
Guindon, J1
LoVerme, J1
De Léan, A1
Piomelli, D1
Beaulieu, P1
Kaushal, M1
Kutty, NG2
Rao, CM2
Dalton, JD1
Schweinle, JE1
Tandon, VR1
Gupta, RK1
Ambrocio, DU1
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Perez, E1
Garrigues, JC1
Bordat, P1
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Kalia, R1
Pozsgai, G1
Sándor, K1
Perkecz, A1
Szolcsányi, J1
Helyes, Z1
Brain, SD1
Pintér, E1
Alexander, F1
Mathieson, M1
Teoh, KH1
Huval, WV1
Lelcuk, S1
Valeri, CR1
Shepro, D1
Hechtman, HB1
Mielens, ZE1
Bhandari, JC1
Barbolt, TA1
Stecher, VJ1
Andersson, S1
Fredin, H1
Lindberg, H1
Sanzén, L1
Westlin, N1
Bossoni, G1
Coppi, G1
Lumachi, B1
Milanino, R1
Passarella, E1
Toson, G1
Valsecchi, B1
Gruber, K1
Engels, B1
Berner, G1
Wagener, HH1
Cioli, V2
Corradino, C2
Putzolu, S2
Pasquini, P1
Rossi, V1
Parola, M1
Curzio, M1
Negro, F1
Paradisi, L1
Torrielli, MV1
Schultze-Mosgau, S1
Schmelzeisen, R1
Frölich, JC1
Schmele, H1
Smith-Oliver, T1
Noel, LS1
Stimpson, SS1
Yarnall, DP1
Connolly, KM1
Teixeira, MM1
Williams, TJ3
Hellewell, PG2
Futaki, N1
Yoshikawa, K1
Hamasaka, Y1
Arai, I1
Higuchi, S1
Iizuka, H1
Otomo, S1
Vázquez, MT1
Guimarães, SA1
Akatsu, T1
Tago, EM1
Consolaro, A1
Pichat, P1
Angel, I1
Arbilla, S1
Schramlová, J1
Blazek, K1
Otová, B1
Bartácková, M1
Hulínská, D1
Barrow, RE1
Ramirez, RJ1
Zhang, XJ1
Cechinel-Filho, V1
Vaz, ZR1
Zunino, L1
Calixto, JB1
Yunes, RA1
Andrade, A1
Namora, SF1
Woisky, RG1
Wiezel, G1
Najjar, R1
Sertié, JA1
de Oliveira Silva, D1
Wilgus, TA1
Ross, MS1
Parrett, ML1
Oberyszyn, TM1
Bansal, AK2
Khar, RK2
Dubey, R2
Vijayakumar, CS1
Viswanathan, S1
Reddy, MK1
Parvathavarthini, S1
Kundu, AB1
Sukumar, E1
Nist, E1
Pickenpaugh, L1
Meyers, WJ1
Peterson, LJ1
Henry, M1
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Krupa, D1
Bolognese, JA1
Sperling, RS1
Reicin, A1
Chiang, HN1
Wu, PC1
Pecora, JL1
Schooley, RT1
Wagley, PF1
Lietman, PS1
Lökken, P1
Olsen, I1
Bruaset, I1
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Aparicio, L1
Meacock, SC1
Kitchen, EA1
Takase, K1
Masumoto, S1
Okumura, M1
Bordi, F1
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Lysell, L1
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Hidaka, T1
Hosoe, K1
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Watanabe, K1
Hiramatsu, Y1
Fujimura, H1
Rampart, M1
Das, DK1
Bandyopadhyay, D1
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Krupińska, J1
Koziej, P1
Stephanus, R1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Clinical Pharmacogenetic of Ibuprofen Enantiomers After Lower Third Molar Surgeries[NCT03169127]Phase 4200 participants (Actual)Interventional2016-04-01Active, not recruiting
Effect on Initial Endodontic Treatment on Postoperative Pain in Symptomatic Teeth With Pulpal Necrosis[NCT01870973]108 participants (Actual)Interventional2013-03-31Completed
Comparison of the Efficacy of Topical Ibuprofen to Oral Ibuprofen in Adolescent Athletes[NCT00567528]60 participants (Actual)Interventional2006-05-31Terminated (stopped due to Study was not producing meaningful data.)
A Randomized, Double-Blind, Parallel-Group Study Comparing the Safety and Effectiveness of Acetaminophen Extended Release (3900 mg/Day) and Ibuprofen (1200 mg/Day) in the Treatment of Ankle Sprains.[NCT00261560]Phase 4260 participants (Actual)InterventionalCompleted
Evaluation of Postoperative Edema and Pain Following Third Molar Extraction With Application of Pulsed Electromagnetic Field (PEMF) Therapy[NCT02376946]49 participants (Actual)Interventional2014-01-31Terminated (stopped due to Sponsor decision)
Assessment of the Operative Course in Connection With Removal of Lower Third Molars With Particular Consideration to the Occurence of Pain and Swelling[NCT00805298]154 participants (Actual)Interventional2008-08-31Completed
Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial.[NCT03033147]72 participants (Actual)Interventional2019-10-18Completed
Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial[NCT03007342]78 participants (Anticipated)Interventional2017-01-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Percent of Patients With Success as Defined by no or Mild Pain as Analyzed on a VAS Scale and no Narcotic Use

"pain measurement as assessed on a visual analog scale and pain medication usage~definition of success = no or mild pain as analyzed on VAS scale and no narcotic use; analyzed by logistic regression~VAS scale is 0 to 170 mm with the higher numbers indicating more pain and less success." (NCT01870973)
Timeframe: each day for 5 days

Interventionpercentage of participants (Number)
Root Canal Treatment52
no Root Canal Treatment43

Reviews

2 reviews available for ibuprofen and Edema

ArticleYear
Bilateral leg edema in an older woman.
    Zeitschrift fur Gerontologie und Geriatrie, 2015, Volume: 48, Issue:1

    Topics: Aged, 80 and over; Chronic Disease; Diagnosis, Differential; Edema; Female; Heart Diseases; Humans;

2015
Red ear syndrome: case report and review of the literature.
    Dermatology (Basel, Switzerland), 2011, Volume: 223, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Ear Diseases; Edema; Erythema; Female; Humans; Hyperhidrosis; Ibupr

2011

Trials

21 trials available for ibuprofen and Edema

ArticleYear
Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a cross-over randomized controlled trial.
    Oral and maxillofacial surgery, 2023, Volume: 27, Issue:4

    Topics: Cross-Over Studies; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative

2023
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
    Medicina oral, patologia oral y cirugia bucal, 2021, Mar-01, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post

2021
Postoperative pain and edema control following different protocols of preemptive analgesia in the surgical removal of impacted third molars: A triple-blind parallel randomized placebo-controlled clinical trial.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2021, Volume: 49, Issue:8

    Topics: Analgesia; Double-Blind Method; Edema; Humans; Ibuprofen; Molar, Third; Pain, Postoperative; Tooth E

2021
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2016, Volume: 74, Issue:8

    Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible;

2016
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of paracetamol, serratiopeptidase, ibuprofen and betamethasone using the dental impaction pain model.
    International journal of oral and maxillofacial surgery, 2009, Volume: 38, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammatory

2009
Antibiotic prophylaxis in third molar surgery: A randomized double-blind placebo-controlled clinical trial using split-mouth technique.
    International journal of oral and maxillofacial surgery, 2010, Volume: 39, Issue:2

    Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Bacterial Agen

2010
Effect of preoperative ibuprofen on pain and swelling after lower third molar removal: a randomized controlled trial.
    International journal of oral and maxillofacial surgery, 2012, Volume: 41, Issue:8

    Topics: Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Edema; Female;

2012
The effect of an 810-nm diode laser on postoperative pain and tissue response after modified Widman flap surgery: a pilot study in humans.
    Journal of periodontology, 2013, Volume: 84, Issue:2

    Topics: Analgesics, Non-Narcotic; Chronic Periodontitis; Color; Combined Modality Therapy; Edema; Female; Hu

2013
Comparative efficacy of a proprietary topical ibuprofen gel and oral ibuprofen in acute soft tissue injuries: a randomized, double-blind study.
    Journal of clinical pharmacy and therapeutics, 2002, Volume: 27, Issue:6

    Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Anti-Inflammatory Agents, Non-St

2002
A randomized, double-blind crossover trial of paracetamol 1000 mg four times daily vs ibuprofen 600 mg: effect on swelling and other postoperative events after third molar surgery.
    British journal of clinical pharmacology, 2003, Volume: 55, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies

2003
Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.
    Kidney international, 2006, Volume: 70, Issue:8

    Topics: Acid-Base Equilibrium; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis,

2006
Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains.
    Annals of emergency medicine, 2006, Volume: 48, Issue:5

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Ankle Injuries; Arthralgia; Contusions; Double-Blind Method

2006
Ibuprofen and compression bandage in the treatment of ankle sprains.
    Acta orthopaedica Scandinavica, 1983, Volume: 54, Issue:2

    Topics: Adult; Ankle Injuries; Bandages; Clinical Trials as Topic; Edema; Female; Humans; Ibuprofen; Male; P

1983
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen;

1995
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen;

1995
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen;

1995
Use of ibuprofen and methylprednisolone for the prevention of pain and swelling after removal of impacted third molars.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1995, Volume: 53, Issue:1

    Topics: Adolescent; Adult; Cheek; Double-Blind Method; Drug Combinations; Edema; Female; Humans; Ibuprofen;

1995
Effect of apical trephination on postoperative pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:6

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Variance; Anti-Infla

2001
Effect of prophylactic amoxicillin on endodontic flare-up in asymptomatic, necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:1

    Topics: Acetaminophen; Adult; Amoxicillin; Analgesics, Non-Narcotic; Analgesics, Opioid; Analysis of Varianc

2001
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla

2001
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla

2001
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla

2001
Effect of penicillin on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2001, Volume: 27, Issue:2

    Topics: Acetaminophen; Administration, Oral; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Infla

2001
Bilateral surgical removal of impacted lower third molar teeth as a model for drug evaluation: a test with ibuprofen.
    European journal of clinical pharmacology, 1975, Apr-04, Volume: 8, Issue:3-4

    Topics: Adolescent; Adult; Clinical Trials as Topic; Drug Evaluation; Edema; Female; Hemostasis; Humans; Ibu

1975
Pain control after third molar surgery--a comparative study of ibuprofen (Ibumetin) and a paracetamol/codeine combination (Citodon).
    Swedish dental journal, 1992, Volume: 16, Issue:4

    Topics: Acetaminophen; Adolescent; Adult; Codeine; Drug Combinations; Edema; Female; Humans; Ibuprofen; Male

1992
A randomized double-blind clinical trial on the effectiveness of helium-neon laser in the prevention of pain, swelling and trismus after removal of impacted third molars.
    International dental journal, 1990, Volume: 40, Issue:1

    Topics: Adult; Double-Blind Method; Edema; Female; Humans; Ibuprofen; Laser Therapy; Male; Molar, Third; Pai

1990
Nabumetone in the treatment of skin and soft tissue injury.
    The American journal of medicine, 1987, Oct-30, Volume: 83, Issue:4B

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butano

1987

Other Studies

156 other studies available for ibuprofen and Edema

ArticleYear
2-(Substituted phenyl)oxazolo[4,5-b]pyridines and 2-(substituted phenyl)oxazolo[5,4-b]pyridines as nonacidic antiinflammatory agents.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1978
Synthesis and antiinflammatory activity of cis-4,5,6,7,8,8a,9-hexahydro-alpha-methyl-5H-fluorene-2-acetic acid.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Arthus Reaction; Edema; Fluorenes; Magnetic Resonance Spectroscop

1977
Nonsteroidal antiinflammatory agents. 1. 5-Alkoxy-3-biphenylylacetic acids and related compounds as new potential antiinflammatory agenst.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:5

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compo

1977
Chemical investigation and anti-inflammatory activity of Vitex negundo seeds.
    Journal of natural products, 1992, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chloroform; Edema; Foot; India; Male;

1992
N-[(arylmethoxy)phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:1

    Topics: Animals; Azoles; Benzamides; Biological Assay; Bronchial Spasm; Carrageenan; Chemical Phenomena; Che

1990
1,2-Dihydro-1-oxopyrrolo[3,2,1-kl]phenothiazine-2-carboxamides and congeners, dual cyclooxygenase/5-lipoxygenase inhibitors with antiinflammatory activity.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate Lipoxygenases; Arachidonic Acid; Arac

1990
Benzimidazole derivatives with atypical antiinflammatory activity.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Benzimidazoles

1987
Synthesis and antiinflammatory activity of hexahydrothiopyrano[4,3-c]pyrazoles and related analogues.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Chemical Phenomena; Che

1982
1-Acyltriazoles as antiinflammatory agents.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthus Reaction; Edema; Ibuprofen; Male;

1982
Bulky amine analogues of ketoprofen: potent antiinflammatory agents.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chemical Phenomena; Chemistry; Drug Eval

1984
Nonsteroidal antiinflammatory agents. 14. Synthesis and pharmacological profile of 6-chloro-5-(cyclopentylmethyl)indan-1-carboxylic acid.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Indans; Indenes; M

1984
Nonsteroidal antiinflammatory agents. 2. [(Heteroarylamino)phenyl]alkanoic acids.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carboxylic Acids; Carrageenan; Edema; Fe

1983
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.
    Journal of medicinal chemistry, 1998, Mar-26, Volume: 41, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Benzofurans; Blood Platelets; Carrageenan; Cyclooxygenase Inhibit

1998
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
    Journal of medicinal chemistry, 1998, Mar-26, Volume: 41, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzofurans; Blood Platelets; Carrageenan; Cyclooxyge

1998
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
    Journal of medicinal chemistry, 1998, Aug-27, Volume: 41, Issue:18

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Cyclooxygena

1998
Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity.
    Journal of medicinal chemistry, 2001, Aug-30, Volume: 44, Issue:18

    Topics: Abdominal Muscles; Androstenols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cycl

2001
A new class of ibuprofen derivatives with reduced gastrotoxicity.
    Journal of medicinal chemistry, 2001, Oct-11, Volume: 44, Issue:21

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclic N-Oxides; Edema; Gastric Mucos

2001
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2003, Nov-06, Volume: 46, Issue:23

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2;

2003
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2004, Jul-29, Volume: 47, Issue:16

    Topics: Analgesics; Animals; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Edema; Isoenzymes; Membrane Pr

2004
New N-pyridinyl(methyl)-indolalkanamides acting as topical inflammation inhibitors.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Administration, Cutaneous; Administration, Oral; Amides; Animals; Anti-Inflammatory Agents, Non-Ster

2004
Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents.
    European journal of medicinal chemistry, 2007, Volume: 42, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship

2007
One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities.
    Bioorganic & medicinal chemistry, 2007, May-15, Volume: 15, Issue:10

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoquinones; Carrageen

2007
2-Amino-5-thiazolyl motif: a novel scaffold for designing anti-inflammatory agents of diverse structures.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Cyclooxygenase Inhib

2008
Synthesis and biological activity of new anti-inflammatory compounds containing the 1,4-benzodioxine and/or pyrrole system.
    Bioorganic & medicinal chemistry, 2007, Jul-15, Volume: 15, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Benzene; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhib

2007
Synthesis, pharmacological activity and hydrolytic behavior of ethylenediamine and benzathine conjugates of ibuprofen.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:12

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dis

2008
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.
    Bioorganic & medicinal chemistry letters, 2008, Jul-15, Volume: 18, Issue:14

    Topics: Acetylene; Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Chemistry, Pharmaceutical

2008
Aroylpropionic acid based 2,5-disubstituted-1,3,4-oxadiazoles: synthesis and their anti-inflammatory and analgesic activities.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Acute Disease; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclizatio

2009
Synthesis and pharmacological evaluation of 2(3H)-furanones and 2(3H)-pyrrolones, combining analgesic and anti-inflammatory properties with reduced gastrointestinal toxicity and lipid peroxidation.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:6

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Furans; Li

2009
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper

2009
Synthesis and pharmacological evaluation of 1,3,4-oxadiazole bearing bis(heterocycle) derivatives as anti-inflammatory and analgesic agents.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:10

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Male; Mice; Molecular Structure; Oxadi

2009
Regioselective reaction: synthesis and pharmacological study of Mannich bases containing ibuprofen moiety.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:9

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspergillus; Edema; Esch

2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.
    Bioorganic & medicinal chemistry, 2009, Jul-15, Volume: 17, Issue:14

    Topics: Animals; Anti-Inflammatory Agents; Azo Compounds; Cyclooxygenase Inhibitors; Edema; Foot; Humans; Ni

2009
Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Acridines; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor;

2010
Design, synthesis and evaluation of novel 2-thiophen-5-yl-3H-quinazolin-4-one analogues as inhibitors of transcription factors NF-kappaB and AP-1 mediated transcriptional activation: Their possible utilization as anti-inflammatory and anti-cancer agents.
    Bioorganic & medicinal chemistry, 2010, Apr-01, Volume: 18, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Carrageenan; Drug Design; E

2010
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.
    Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Edema; Est

2011
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell S

2011
New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacillus subtilis; Carragee

2011
Synthesis and anti-inflammatory activity of some novel 3-phenyl-N-[3-(4-phenylpiperazin-1yl)propyl]-1H-pyrazole-5-carboxamide derivatives.
    Bioorganic & medicinal chemistry letters, 2011, Jul-15, Volume: 21, Issue:14

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Pyrazoles; Rats

2011
Synthesis and anti-inflammatory activity of novel biscoumarin-chalcone hybrids.
    Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chalcone; Coumarins; Edema; Microsomes; Rats

2011
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.
    Journal of medicinal chemistry, 2012, Jan-26, Volume: 55, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Binding Sites; Cyclooxygenase 1; Cyclooxy

2012
Design, synthesis, biological evaluation, and comparative Cox1 and Cox2 docking of p-substituted benzylidenamino phenyl esters of ibuprofenic and mefenamic acids.
    Bioorganic & medicinal chemistry, 2012, Feb-01, Volume: 20, Issue:3

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Drug Design; Edema; Ibupr

2012
Synthesis of novel 2-mercapto benzothiazole and 1,2,3-triazole based bis-heterocycles: their anti-inflammatory and anti-nociceptive activities.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Benzothiazoles; Click Chemistry; Cyclooxygenase Inhib

2012
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2012, May-01, Volume: 20, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Binding Sites; Catalytic Domain; Com

2012
Eco-friendly synthesis and biological evaluation of substituted pyrano[2,3-c]pyrazoles.
    Bioorganic & medicinal chemistry letters, 2012, Aug-15, Volume: 22, Issue:16

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Cell Proliferation; Crystallography, X-Ray

2012
Synthesis and evaluation of mutual prodrugs of ibuprofen with menthol, thymol and eugenol.
    European journal of medicinal chemistry, 2012, Volume: 56

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Eugenol; Female; Hydrogen-Ion

2012
A facile synthesis, anti-inflammatory and analgesic activity of isoxazolyl-2,3-dihydrospiro[benzo[f]isoindole-1,3'-indoline]-2',4,9-triones.
    Bioorganic & medicinal chemistry letters, 2013, Jul-01, Volume: 23, Issue:13

    Topics: Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dos

2013
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
    European journal of medicinal chemistry, 2015, Jan-07, Volume: 89

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup

2015
Environmentally benign synthesis, molecular properties prediction and anti-inflammatory activity of novel isoxazolo[5,4-d]isoxazol-3-yl-aryl-methanones via vinylogous Henry nitroaldol adducts as synthons.
    Bioorganic & medicinal chemistry letters, 2015, Apr-01, Volume: 25, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; C

2015
2'-Hydroxy flavanone derivatives as an inhibitors of pro-inflammatory mediators: Experimental and molecular docking studies.
    Bioorganic & medicinal chemistry letters, 2015, May-01, Volume: 25, Issue:9

    Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Edema; Flavanones; Inflammation

2015
Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2015, Nov-15, Volume: 25, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cinnamates; Edema; Esters; Glycine ma

2015
Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity.
    Bioorganic & medicinal chemistry letters, 2016, Feb-01, Volume: 26, Issue:3

    Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholesterol; Cholesterol, LDL; Edema; Hype

2016
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
    Journal of natural products, 2016, Apr-22, Volume: 79, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Dinoprostone; Disease Models, Anim

2016
Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties.
    Bioorganic & medicinal chemistry letters, 2017, 11-01, Volume: 27, Issue:21

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents; Antioxidants; Butanes; Carrageenan; Chemical and D

2017
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
    Bioorganic & medicinal chemistry, 2018, 02-15, Volume: 26, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Benzoxazoles; Binding Sites; Catalytic Domain; Cattle; Cyclooxyge

2018
Synthesis and biological properties of aryl methyl sulfones.
    Bioorganic & medicinal chemistry, 2018, 08-07, Volume: 26, Issue:14

    Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Carrageenan; Dimet

2018
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore.
    Bioorganic & medicinal chemistry, 2020, 05-01, Volume: 28, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; Cattle; Cyclooxygenase 1; Cyclooxy

2020
Synthesis, pharmacological profile and 2D-QSAR studies of curcumin-amino acid conjugates as potential drug candidates.
    European journal of medicinal chemistry, 2020, Jun-15, Volume: 196

    Topics: Amino Acids; Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; An

2020
In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae).
    Journal of ethnopharmacology, 2022, Jul-15, Volume: 293

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen

2022
Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol.
    Molecules (Basel, Switzerland), 2022, Mar-24, Volume: 27, Issue:7

    Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan

2022
New NSAID Conjugates as Potent and Selective COX-2 Inhibitors: Synthesis, Molecular Modeling and Biological Investigation.
    Molecules (Basel, Switzerland), 2023, Feb-17, Volume: 28, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen

2023
Anti-rheumatic activity of Phenethyl isothiocyanate via inhibition of histone deacetylase-1.
    Chemico-biological interactions, 2020, Jun-01, Volume: 324

    Topics: Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumat

2020
Synthesis of new ibuprofen hybrid conjugates as potential anti-inflammatory and analgesic agents.
    Future medicinal chemistry, 2020, Volume: 12, Issue:15

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygena

2020
CYP450 polymorphisms and clinical pharmacogenetics of ibuprofen after lower third molar extraction.
    European journal of clinical pharmacology, 2021, Volume: 77, Issue:5

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Body Mass Index; Cytochrome P-450 CYP2C8

2021
Evaluation and comparison of anti-inflammatory properties of ibuprofen using two drug delivery systems after third molar surgery: using chitosan microspheres as a carrier for local drug delivery in to the third molar socket and through the oral route.
    The British journal of oral & maxillofacial surgery, 2021, Volume: 59, Issue:2

    Topics: Anti-Inflammatory Agents; Chitosan; Drug Delivery Systems; Edema; Humans; Ibuprofen; Mandible; Micro

2021
New ibuprofen derivatives with thiazolidine-4-one scaffold with improved pharmaco-toxicological profile.
    BMC pharmacology & toxicology, 2021, 02-04, Volume: 22, Issue:1

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cell Surviva

2021
Young child with painful edema and purpura: a case report.
    Italian journal of pediatrics, 2021, Mar-10, Volume: 47, Issue:1

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Hemorrhage;

2021
The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of
    Molecules (Basel, Switzerland), 2021, Jun-17, Volume: 26, Issue:12

    Topics: Administration, Oral; Administration, Topical; Animals; Anti-Inflammatory Agents; Diclofenac; Edema;

2021
Design and Synthesis of Novel Ibuprofen Derivatives as Selective COX-2 Inhibitors and Potential Anti-Inflammatory Agents: Evaluation of PGE2, TNF-α, IL-6 and Histopathological Study.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2022, Volume: 18, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygen

2022
Hypersensitivity Reaction to Yellow Jacket Sting in a Previously Nonallergic Patient Taking an Angiotensin Receptor Blocker.
    Wilderness & environmental medicine, 2017, Volume: 28, Issue:2

    Topics: Aged; Angiotensin Receptor Antagonists; Animals; Anti-Allergic Agents; Diphenhydramine; Edema; Human

2017
Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats.
    Inflammopharmacology, 2017, Volume: 25, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Carrageenan; Edema; Gastric Mucosa;

2017
Synergistic analgesic, anti-pyretic and anti-inflammatory effects of extra virgin olive oil and ibuprofen in different experimental models of albino mice.
    International journal of rheumatic diseases, 2017, Volume: 20, Issue:10

    Topics: Acetic Acid; Albinism; Analgesics; Animals; Anti-Inflammatory Agents; Antipyretics; Carrageenan; Din

2017
Synthesis of substituted fluorobenzimidazoles as inhibitors of 5-lipoxygenase and soluble epoxide hydrolase for anti-inflammatory activity.
    Archiv der Pharmazie, 2018, Volume: 351, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arachidonate 5-Lipoxygenase; Benzimidazoles; Carrageenan; Disease

2018
Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents.
    Archiv der Pharmazie, 2018, Volume: 351, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Benzamides; Benzoxazoles; Carrageenan; Cyclooxygenase 1; Cyclooxy

2018
Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice.
    Inflammopharmacology, 2019, Volume: 27, Issue:3

    Topics: Animals; Butylscopolammonium Bromide; Disease Models, Animal; Dysmenorrhea; Edema; Euphorbia; Female

2019
Systemic treatment with resveratrol reduces the progression of experimental periodontitis and arthritis in rats.
    PloS one, 2018, Volume: 13, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Dis

2018
Similar pain, swelling, and trismus after third-molar surgical extraction when receiving a phytotherapeutic drug, ibuprofen, or a placebo.
    Journal of the American Dental Association (1939), 2019, Volume: 150, Issue:5

    Topics: Edema; Humans; Ibuprofen; Molar; Molar, Third; Pain; Plant Extracts; Tooth Extraction; Tooth, Impact

2019
Formulation of topical ibuprofen solid lipid nanoparticle (SLN) gel using hot melt extrusion technique (HME) and determining its anti-inflammatory strength.
    Drug delivery and translational research, 2019, Volume: 9, Issue:4

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Carriers; Drug Lib

2019
Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs.
    International journal of pharmaceutics, 2014, May-15, Volume: 466, Issue:1-2

    Topics: 1-Octanol; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Car

2014
Evaluation of anti-inflammatory and analgesic effects of synthesized derivatives of ibuprofen.
    Chemical biology & drug design, 2015, Volume: 85, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Cyclooxygenase 1; Cy

2015
S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice.
    Behavioural pharmacology, 2014, Volume: 25, Issue:3

    Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, A

2014
Mechanical properties, skin permeation and in vivo evaluations of dexibuprofen-loaded emulsion gel for topical delivery.
    Archives of pharmacal research, 2015, Volume: 38, Issue:2

    Topics: Adhesiveness; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Deli

2015
Development of ibuprofen nanoliposome for transdermal delivery: Physical characterization, in vitro/in vivo studies, and anti-inflammatory activity.
    Artificial cells, nanomedicine, and biotechnology, 2016, Volume: 44, Issue:1

    Topics: Acrylates; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Area Under C

2016
Design of Block Copolymer Costabilized Nonionic Microemulsions and Their In Vitro and In Vivo Assessment as Carriers for Sustained Regional Delivery of Ibuprofen via Topical Administration.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:8

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparat

2015
Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.
    Bioorganic chemistry, 2016, Volume: 64

    Topics: Animals; Anti-Inflammatory Agents; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 I

2016
Formulation of hydrogel-thickened nonionic microemulsions with enhanced percutaneous delivery of ibuprofen assessed in vivo in rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2016, Sep-20, Volume: 92

    Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan;

2016
Delayed retrobulbar haemorrhage associated with a repeat sub-Tenon's block.
    Anaesthesia and intensive care, 2008, Volume: 36, Issue:5

    Topics: Acetaminophen; Acetazolamide; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents

2008
Synthesis and evaluation of anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation properties of ibuprofen derivatives.
    Acta pharmaceutica (Zagreb, Croatia), 2007, Volume: 57, Issue:1

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Female; Gastric Mu

2007
Periorbital edema associated with separate courses of ibuprofen and naproxen.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2010, Jun-01, Volume: 67, Issue:11

    Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Edema; Eye Diseases; Female; Humans; Ibu

2010
Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat.
    Inflammopharmacology, 2011, Volume: 19, Issue:5

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose

2011
ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
    Inflammation, 2012, Volume: 35, Issue:3

    Topics: Activating Transcription Factor 6; Adjuvants, Immunologic; Animals; Anthraquinones; Anti-Inflammator

2012
In vitro and in vivo evaluation of ibuprofen-paeonol conjugate.
    Journal of controlled release : official journal of the Controlled Release Society, 2011, Nov-30, Volume: 152 Suppl 1

    Topics: Acetic Acid; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceuti

2011
Biological activity of some derivatives of β-cyclodextrin.
    Bulletin of experimental biology and medicine, 2011, Volume: 151, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; beta-Cyclodextrins; Edema; Ibuprofen; Mice; Molecular St

2011
TRPA1 contributes to the acute inflammatory response and mediates carrageenan-induced paw edema in the mouse.
    Scientific reports, 2012, Volume: 2

    Topics: Acetanilides; Animals; Carrageenan; Edema; HEK293 Cells; Humans; Ibuprofen; Mice; Mice, Inbred C57BL

2012
Improved dissolution and anti-inflammatory effect of ibuprofen by solid dispersion.
    Frontiers of medicine, 2012, Volume: 6, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Carriers; Edema; Ibup

2012
Thiazolo[3,2-b]-1,2,4-triazole-5(6H)-one substituted with ibuprofen: novel non-steroidal anti-inflammatory agents with favorable gastrointestinal tolerance.
    European journal of medicinal chemistry, 2012, Volume: 57

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi

2012
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
    Journal of dietary supplements, 2012, Volume: 9, Issue:3

    Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For

2012
Pharmaco-modulations of induced edema and vascular permeability changes by Vipera lebetina venom: inflammatory mechanisms.
    Inflammation, 2013, Volume: 36, Issue:2

    Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Capil

2013
Acute calcific tendinitis of the wrist.
    The Journal of emergency medicine, 2013, Volume: 44, Issue:2

    Topics: Acute Disease; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Calcinosis; Chills; Edema

2013
Assessment of spinal cord pathology following trauma using early changes in the spinal cord evoked potentials: a pharmacological and morphological study in the rat.
    Muscle & nerve. Supplement, 2002, Volume: 11

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents; Anti-I

2002
Effect of drainage upon access on postoperative endodontic pain and swelling in symptomatic necrotic teeth.
    Journal of endodontics, 2002, Volume: 28, Issue:8

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St

2002
Postoperative complaints following impacted mandibular third molar surgery in Ile-Ife, Nigeria.
    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 2002, Volume: 57, Issue:7

    Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Edema; Female; Humans; Ibuprofen; Male;

2002
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents.
    European journal of medicinal chemistry, 2003, Volume: 38, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Carrageenan; Dime

2003
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Eating; Edema; Estradiol;

2003
Painful, swollen lower legs.
    The Journal of family practice, 2003, Volume: 52, Issue:10

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Erythema Nodosum; Fe

2003
Anti-inflammatory action of sulfoaryl 3,3-disubstituted triazenes in rat experimental edema models.
    Die Pharmazie, 2003, Volume: 58, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bentonite; Carrageenan; Chemical Phenomen

2003
Synthesis and analgesic-anti-inflammatory activities of some 1,2,4-triazine derivatives.
    Arzneimittel-Forschung, 2004, Volume: 54, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Ibuprofen; Indicators and Reag

2004
Design, synthesis, and pharmacological evaluation of some 2-[4-morpholino]-3-aryl-5-substituted thiophenes as novel anti-inflammatory agents: generation of a novel anti-inflammatory pharmacophore.
    Bioorganic & medicinal chemistry, 2004, Sep-01, Volume: 12, Issue:17

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design;

2004
Localized periorbital edema induced by Ibuprofen.
    The Journal of dermatology, 2005, Volume: 32, Issue:12

    Topics: Adult; Dose-Response Relationship, Drug; Drug Administration Schedule; Edema; Female; Follow-Up Stud

2005
Pharmacological activity and hydrolysis behavior of novel ibuprofen glucopyranoside conjugates.
    European journal of medicinal chemistry, 2006, Volume: 41, Issue:11

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Edema; Female

2006
Chondroitin sulfate-based anti-inflammatory macromolecular prodrugs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2006, Volume: 29, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Carrageenan; Chemical Phenomena; Chemis

2006
New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity.
    Archiv der Pharmazie, 2006, Volume: 339, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Carrageenan; Cell Survival; Dis

2006
Synergistic antinociceptive effects of anandamide, an endocannabinoid, and nonsteroidal anti-inflammatory drugs in peripheral tissue: a role for endogenous fatty-acid ethanolamides?
    European journal of pharmacology, 2006, Nov-21, Volume: 550, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Capsaicin; Chromatography, High

2006
Nitrooxyethylation reverses the healing-suppressant effect of Ibuprofen.
    Mediators of inflammation, 2006, Volume: 2006, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cicatrix; Collagen; Edema; Granulation Tissue; Ibu

2006
Vitex negundo Linn (VN) leaf extract as an adjuvant therapy to standard anti-inflammatory drugs.
    The Indian journal of medical research, 2006, Volume: 124, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemotherapy, Adjuvant; Edema; Female; Granuloma;

2006
57-year-old Asian-American man with Kikuchi's disease.
    Hawaii medical journal, 2006, Volume: 65, Issue:11

    Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Asian; Biopsy; Diagno

2006
Design of original bioactive formulations based on sugar-surfactant/non-steroidal anti-inflammatory catanionic self-assemblies: a new way of dermal drug delivery.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2007, Volume: 13, Issue:11

    Topics: Administration, Topical; Animals; Anions; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid;

2007
Synthesis and evaluation of the antiinflammatory activity of N-[2-(3,5-di-tert-butyl-4-hydroxyphenyl)-4-oxo-thiazolidin-3-yl]-nicotinamide.
    Arzneimittel-Forschung, 2007, Volume: 57, Issue:9

    Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Exp

2007
Topical acetone treatment induces neurogenic oedema on the sensitized mouse ear: an in vivo study using transient receptor potential vanilloid 1 (TRPV1) receptor knockout mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007, Volume: 56, Issue:11

    Topics: Acetone; Administration, Cutaneous; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroi

2007
Arachidonic acid metabolites mediate early burn edema.
    The Journal of trauma, 1984, Volume: 24, Issue:8

    Topics: Animals; Body Water; Burns; Calcium Channel Blockers; Capillary Permeability; Chromones; Edema; Ibup

1984
Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs.
    Agents and actions, 1984, Volume: 15, Issue:3-4

    Topics: Aminophylline; Animals; Anti-Inflammatory Agents; Arthus Reaction; Colchicine; Edema; Guinea Pigs; H

1984
[Pharmacologic profile of a new compound with antiinflammatory activity: 2-(4-dimethylvinylphenyl)propionic acid (Gx 258)].
    Il Farmaco; edizione scientifica, 1984, Volume: 39, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental;

1984
[Pharmacologic-toxicologic study of an ibuprofen-containing creme].
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:8

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Erythema; Female; Gr

1983
Additional pharmacological studies on ibuprofen guaiacol ester (AF 2259).
    Bollettino chimico farmaceutico, 1983, Volume: 122, Issue:1

    Topics: Analgesics; Animals; Antitussive Agents; Edema; Female; Guaiacol; Guinea Pigs; Ibuprofen; Male; Mice

1983
A toxicological and pharmacological study of ibuprofen guaiacol ester (AF 2259) in the rat.
    Toxicology and applied pharmacology, 1980, Jun-30, Volume: 54, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Digestive System; Edema; Female;

1980
[Lipid peroxidation in the rat liver after acute inflammation induced by carrageenan. I. Influence of non-steroidal anti-inflammatory agents].
    Bollettino della Societa italiana di biologia sperimentale, 1981, Mar-30, Volume: 57, Issue:6

    Topics: Animals; Carbon Tetrachloride; Carrageenan; Edema; Ibuprofen; Indomethacin; Inflammation; Lipid Pero

1981
Elevated levels of TNF in the joints of adjuvant arthritic rats.
    Cytokine, 1993, Volume: 5, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Biological Assay; Cells,

1993
Role of prostaglandins and nitric oxide in acute inflammatory reactions in guinea-pig skin.
    British journal of pharmacology, 1993, Volume: 110, Issue:4

    Topics: Acute Disease; Alprostadil; Animals; Arginine; Dermatitis; Edema; Female; Guinea Pigs; Ibuprofen; Le

1993
NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
    General pharmacology, 1993, Volume: 24, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Cyclooxygena

1993
Synthesis and antiinflammatory activity of 2,3-dihydro-1,4-benzodioxin methyl carboxylic acids.
    Farmaco (Societa chimica italiana : 1989), 1996, Volume: 51, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dioxins; Edema; Foot; Ibuprofen; Male

1996
Assessment of the antiexudative and antiproliferative activities of non-steroidal anti-inflammatory drugs in inflammatory models developed in rats by subcutaneous implantation of bacterial cell walls from the dental plaque.
    Inflammation, 1996, Volume: 20, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary Permeability; Cell Division; Cell Wall;

1996
Anti-inflammatory properties of mizolastine after oral administration on arachidonic acid-induced cutaneous reaction in the rat.
    Arzneimittel-Forschung, 1998, Volume: 48, Issue:2

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Ar

1998
The effect of an antiphlogistic incorporated in liposomes on experimentally induced inflammation.
    Folia biologica, 1997, Volume: 43, Issue:5

    Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Connective

1997
Ibuprofen modulates tissue perfusion in partial-thickness burns.
    Burns : journal of the International Society for Burn Injuries, 2000, Volume: 26, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Burns; Ear,

2000
Antinociceptive and anti-oedematogenic properties of astilbin, taxifolin and some related compounds.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:3

    Topics: Acetaminophen; Acetates; Analgesics; Analgesics, Non-Narcotic; Animals; Aspirin; Edema; Flavonoids;

2000
Synthesis and characterization of a diruthenium-ibuprofenato complex comparing its anti-inflammatory activity with that of a copper(II)-ibuprofenato complex.
    Journal of inorganic biochemistry, 2000, Jul-15, Volume: 81, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Gastrointestinal Hemorrhage; I

2000
Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation.
    Prostaglandins & other lipid mediators, 2000, Volume: 62, Issue:4

    Topics: Administration, Topical; Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy

2000
Activity profile of glycolamide ester prodrugs of ibuprofen.
    Drug development and industrial pharmacy, 2001, Volume: 27, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Esters;

2001
Anti-inflammatory activity of (+)-usnic acid.
    Fitoterapia, 2000, Volume: 71, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Dose-Response Relationsh

2000
Alkyl ester prodrugs for improved topical delivery of ibuprofen.
    Indian journal of experimental biology, 2001, Volume: 39, Issue:3

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Ibuprofen; Prodrug

2001
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
    Current medical research and opinion, 2002, Volume: 18, Issue:2

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinic

2002
Kinetics and hydrolysis mechanism of polymeric prodrugs containing ibuprofen, ketoprofen, and naproxen as pendent agents.
    Journal of biomaterials science. Polymer edition, 2002, Volume: 13, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Stability; Edema; Female; Hydrogen-Ion Concen

2002
Ibuprofen in the treatment of macular edema and central serous chorioretinopathy.
    Annals of ophthalmology, 1979, Volume: 11, Issue:3

    Topics: Choroid; Edema; Humans; Ibuprofen; Macula Lutea; Retinal Diseases; Uveal Diseases

1979
Edema associated with ibuprofen therapy.
    JAMA, 1977, Apr-18, Volume: 237, Issue:16

    Topics: Aged; Diuresis; Edema; Humans; Ibuprofen; Male; Pain; Phenylpropionates

1977
Some aspects of the pharmacology of butibufen, a non-steroidal anti-inflammatory agent.
    Archives internationales de pharmacodynamie et de therapie, 1977, Volume: 227, Issue:1

    Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Edema; Gr

1977
Some effects of non-steroidal anti-inflammatory drugs on leucocyte migration.
    Agents and actions, 1976, Volume: 6, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Cell Movement; Edema; Fenoprofen; Ibuprofen

1976
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu

1975
4-(1,2-Benzisothiazol-3-yl)alkanoic and phenylalkanoic acids: synthesis and anti-inflammatory, analgesic and antipyretic activities.
    Farmaco (Societa chimica italiana : 1989), 1992, Volume: 47, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Edema; Escherichia coli; Ibuprofen; M

1992
Anti-inflammatory efficacy and gastrointestinal irritancy: comparative 1 month repeat oral dose studies in the rat with nabumetone, ibuprofen and diclofenac.
    Agents and actions. Supplements, 1991, Volume: 32

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carrageenan; Diclofenac; E

1991
[Effects of alminoprofen on the allergic reactions].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 96, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonate 5-Lipoxygenase; Bronchoconstriction;

1990
Early postburn lipid peroxidation: effect of ibuprofen and allopurinol.
    Surgery, 1990, Volume: 107, Issue:1

    Topics: Allopurinol; Animals; Burns; Disease Models, Animal; Edema; Ibuprofen; Inflammation; Lipid Peroxidat

1990
Characteristics of oedema formation induced by N-formyl-methionyl-leucyl-phenylalanine in rabbit skin.
    British journal of pharmacology, 1989, Volume: 97, Issue:1

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bradykinin; Colchicine; Dinoprostone; Edema; Endotoxin

1989
Analgesic and anti-inflammatory activities in rats of alpha-(3,5-di-t-butyl-4-hydroxybenzylidene)-gamma-butyrolactone (KME-4), and its intestinal damage.
    The Journal of pharmacy and pharmacology, 1986, Volume: 38, Issue:10

    Topics: 4-Butyrolactone; Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis,

1986
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition.
    Biochemical pharmacology, 1986, Feb-15, Volume: 35, Issue:4

    Topics: Animals; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Ibuprofen; Imidazoles; Indomethac

1986
Role of polymorphonuclear leukocytes in hyperoxic lung injury. Prevention of neutrophil influx into the lung endothelium during oxygen exposure by ibuprofen.
    Biomedica biochimica acta, 1988, Volume: 47, Issue:12

    Topics: Animals; Cell Survival; Chemotaxis, Leukocyte; Edema; Ibuprofen; Indium Radioisotopes; Lung; Neutrop

1988
Topical ibuprofen decreases early postburn edema.
    Surgery, 1987, Volume: 102, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Topical; Animals; Burns; Edema; Ibuprofen; Lymph; Pros

1987
[Synthesis and preliminary pharmacological studies of new derivatives of 2-(4-isobutylphenyl)propionic acid (brufen)].
    Acta poloniae pharmaceutica, 1985, Volume: 42, Issue:6

    Topics: Animals; Drug Evaluation, Preclinical; Edema; Ibuprofen; Male; Mice; Mice, Inbred Strains; Rats; Rat

1985