ibuprofen has been researched along with Ectopic Ossification in 15 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Celecoxib was more effective than ibuprofen in preventing heterotopic bone formation after total hip replacement." | 2.73 | Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial. ( Hoffmeyer, P; Keller, A; Perneger, T; Riand, N; Saudan, M; Saudan, P, 2007) |
| "Both ibuprofen-treated groups showed significantly less HO than the placebo-treated group." | 2.69 | Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time. ( Nilsson, OS; Persson, PE; Sodemann, B, 1998) |
| "In the 22 patients with heterotopic ossification this was demonstrated in all but eight within 6 weeks, and in only three did it appear later than 3 months postoperatively." | 2.66 | Effect of ibuprofen on heterotopic ossification after hip replacement. ( Elmstedt, E; Lindholm, TS; Nilsson, OS; Törnkvist, H, 1985) |
| "Ibuprofen has been also proposed for the prevention of HO following THA." | 1.91 | Efficacy of ibuprofen and indomethacin as prophylaxis of heterotopic ossification: a comparative study. ( Bell, A; Eschweiler, J; Hildebrand, F; Maffulli, N; Migliorini, F; Schneider, J, 2023) |
| "Introduction Heterotopic ossification is the formation of lamellar bone in periarticular soft tissue that can be seen in paralysed patients or following trauma." | 1.48 | Massive heterotopic ossification after distal femur fracture. ( Cakir Kandemirli, G; Ozcakir, S; Ozkocak, G, 2018) |
| "Eighteen (90%) wounds in the saline-chitosan group and 11 (55%) wounds in the saline-gauze group were healed." | 1.42 | Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention. ( Hsu, JR; Noel, SP; Rathbone, CR; Rivera, JC; Wenke, JC, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 4 (26.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Schneider, J | 1 |
| Maffulli, N | 1 |
| Eschweiler, J | 1 |
| Bell, A | 1 |
| Hildebrand, F | 1 |
| Migliorini, F | 1 |
| Ozkocak, G | 1 |
| Cakir Kandemirli, G | 1 |
| Ozcakir, S | 1 |
| Rivera, JC | 1 |
| Hsu, JR | 1 |
| Noel, SP | 1 |
| Wenke, JC | 1 |
| Rathbone, CR | 1 |
| Kopp, MA | 1 |
| Liebscher, T | 1 |
| Watzlawick, R | 1 |
| Martus, P | 1 |
| Laufer, S | 1 |
| Blex, C | 1 |
| Schindler, R | 1 |
| Jungehulsing, GJ | 1 |
| Knüppel, S | 1 |
| Kreutzträger, M | 1 |
| Ekkernkamp, A | 1 |
| Dirnagl, U | 1 |
| Strittmatter, SM | 1 |
| Niedeggen, A | 1 |
| Schwab, JM | 1 |
| Fransen, M | 2 |
| Persson, PE | 4 |
| Nilsson, OS | 6 |
| Berggren, AM | 1 |
| Anderson, C | 1 |
| Douglas, J | 1 |
| MacMahon, S | 1 |
| Neal, B | 1 |
| Norton, R | 1 |
| Woodward, M | 1 |
| Cameron, ID | 1 |
| Crawford, R | 1 |
| Lo, SK | 1 |
| Tregonning, G | 1 |
| Windolf, M | 1 |
| Saudan, M | 1 |
| Saudan, P | 1 |
| Perneger, T | 1 |
| Riand, N | 1 |
| Keller, A | 1 |
| Hoffmeyer, P | 1 |
| Törnkvist, H | 3 |
| Bauer, FC | 1 |
| Lindholm, TS | 2 |
| Ahrengart, L | 1 |
| Blomgren, G | 1 |
| Sodemann, B | 3 |
| Koorevaar, CT | 1 |
| Hu, HP | 1 |
| Lemmens, A | 1 |
| van Kampen, A | 1 |
| Elmstedt, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Rho-Inhibitor Ibuprofen for the Treatment of Acute Spinal Cord Injury: Investigation of Safety, Feasibility and Pharmacokinetics[NCT02096913] | Phase 1 | 12 participants (Actual) | Interventional | 2013-06-30 | Completed | ||
| A Multicentre Randomised Placebo-Controlled Trail of Ibuprofen for the Prevention of Ectopic Bone-Related Pain and Disability After Elective Hip Replacement Surgery (HIPAID)[NCT00145730] | Phase 4 | 1,000 participants | Interventional | 2002-02-28 | Completed | ||
| Non Steroidal Antiinflammatory Drugs Influence on Heal of Distal Radius Fracture[NCT01567072] | Phase 3 | 192 participants (Actual) | Interventional | 2012-04-30 | Completed | ||
| The Effect of Celecoxib on Heterotopic Bone Formation Following Cementless Total Hip Arthroplasty[NCT05648916] | 200 participants (Anticipated) | Observational | 2022-08-02 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 trials available for ibuprofen and Ectopic Ossification
| Article | Year |
|---|---|
SCISSOR-Spinal Cord Injury Study on Small molecule-derived Rho inhibition: a clinical study protocol.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastrointestinal Hemorrhag | 2016 |
Do non-steroidal anti-inflammatory drugs cause endoprosthetic loosening? A 10-year follow-up of a randomized trial on ibuprofen for prevention of heterotopic ossification after hip arthroplasty.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cyclooxygenase Inhibitors; | 2005 |
Safety and efficacy of routine postoperative ibuprofen for pain and disability related to ectopic bone formation after hip replacement surgery (HIPAID): randomised controlled trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Australia; Double-Blind Met | 2006 |
Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial.
Topics: Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Celecoxib; Cyclooxygenase 2 Inhibito | 2007 |
Short-term ibuprofen to prevent ossification after hip arthroplasty. No effects in a prospective randomized study of 47 arthrosis cases.
Topics: Aged; Double-Blind Method; Female; Hip Prosthesis; Humans; Ibuprofen; Male; Middle Aged; Ossificatio | 1994 |
Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Double-Blind Method; Female | 1998 |
No effective prophylaxis of heterotopic ossification with short-term ibuprofen.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, | 1999 |
Effect of ibuprofen on heterotopic ossification after hip replacement.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hip Prosthesis; Humans; Ibuprofen; Male | 1985 |
7 other studies available for ibuprofen and Ectopic Ossification
| Article | Year |
|---|---|
Efficacy of ibuprofen and indomethacin as prophylaxis of heterotopic ossification: a comparative study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Female; Humans; Ibupr | 2023 |
Massive heterotopic ossification after distal femur fracture.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Femoral Fractures; Humans; Ibuprofen; Knee Joint; Ma | 2018 |
Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Prolife | 2015 |
Preventing chronic ectopic bone-related pain and disability after hip replacement surgery with perioperative ibuprofen. A multicenter, randomized, double-blind, placebo-controlled trial (HIPAID).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Australia; Chemotherapy, Ad | 2004 |
Experimentally induced heterotopic ossification in rats influenced by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Bone Matrix; Calcium Radioisotopes; Flurbiprofen; Ib | 1983 |
Prevention of heterotopic ossification by nonsteroid antiinflammatory drugs after total hip arthroplasty.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Hip Joint; Hip Prosthesis; Humans; Ibuprofen; | 1988 |
Prevention of periarticular heterotopic ossification following total hip arthroplasty. Clinical experience with indomethacin and ibuprofen.
Topics: Aged; Aged, 80 and over; Female; Hip Prosthesis; Humans; Ibuprofen; Indomethacin; Male; Middle Aged; | 1988 |