ibuprofen has been researched along with Dysmenorrhea in 87 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Dysmenorrhea: Painful menstruation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Needling and ibuprofen are often used clinically to treat primary dysmenorrhea (PD)." | 9.22 | The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen: A systematic review and meta-analysis. ( Cao, Q; Fu, Y; Huang, Y; Li, L; Liu, D; Xuan, Y; Zhang, H, 2022) |
| "Study was planned to evaluate the efficacy and safety of lornoxicam in moderate to severe menstrual pain due to primary dysmenorrhea." | 9.20 | Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study. ( Acharya, H; Nakum, K; Patel, JC; Patel, PB; Tripathi, CB, 2015) |
| "Preliminary evaluation of efficacy and safety of uzara use in treatment of moderate and severe primary dysmenorrhea in comparison to ibuprofen." | 9.19 | A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea. ( Abd-El-Maeboud, KH; Ali, MS; Ibrahim, MI; Kortam, MA; Mohamed, RM, 2014) |
| "Heat patch containing Iron chip has comparable analgesic effects to ibuprofen and can possibly be used for primary dysmenorrhea." | 9.16 | Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial. ( Kermansaravi, F; Khazaian, S; Navidian, A; Navvabi Rigi, S; Safabakhsh, L; Safarzadeh, A; Salehian, T; Shafie, S, 2012) |
| "In patients experiencing acute visceral pain as a result of primary dysmenorrhea, dexibuprofen was associated with a dose-dependent effective analgesia; this effect was at least equivalent to that of the double dose of ibuprofen." | 9.14 | ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial. ( Kaehler, ST; Kollenz, C; Phleps, W, 2009) |
| "Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea." | 9.14 | Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. ( Goli, M; Moattar, F; Ozgoli, G, 2009) |
| "The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea." | 9.12 | Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. ( Dawood, MY; Khan-Dawood, FS, 2007) |
| "The present study aims at comparing the effects of acupressure using new combination of acupoints, and Ibuprofen on the severity of primary dysmenorrhea (PD)." | 9.10 | Effects of acupressure and ibuprofen on the severity of primary dysmenorrhea. ( Ibrahimzadeh, R; Pouresmail, Z, 2002) |
| " Naproxen 400 mg provided greater pain relief than acetaminophen and placebo within 30 minutes of administration (P < 0." | 9.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "In double-blind studies, mefenamic acid (group A) was compared with ibuprofen (group B) in the treatment of primary dysmenorrhea in 60 patients, during two cycles." | 9.08 | [Treatment of primary dysmenorrhea. Comparative study of ibuprofen and mefenamic acid]. ( Pedrón Nuevo, DN, 1995) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 9.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 9.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "In a randomized four-way crossover study, 32 women with primary dysmenorrhea were treated with transcutaneous electrical nerve stimulation (TENS) for two cycles, placebo (sham) TENS for one cycle, or ibuprofen 400 mg four times a day for one cycle." | 9.06 | Transcutaneous electrical nerve stimulation (TENS) for the treatment of primary dysmenorrhea: a randomized crossover comparison with placebo TENS and ibuprofen. ( Dawood, MY; Ramos, J, 1990) |
| "Fifty-five women with primary dysmenorrhea were enrolled in a study which each took ibuprofen (400 mg), propoxyphene hydrochloride (64 mg), or a placebo alternately in consecutive menstrual cycles for relief of pain." | 9.05 | Analgesic efficacy of ibuprofen for treatment of primary dysmenorrhea. ( Bates, GW; Blake, PG; Forman, EK; Linden, CV; Ling, FW; Morrison, JC; O'Connell, MJ; Vecchio, TJ, 1980) |
| "Forty-two women with primary dysmenorrhea were successfully enrolled in a double-blind, three-way crossover study in which each patient received either ibuprofen (Motrin), indomethacin (Indocin), or a placebo during each of three successive painful menstrual cycles." | 9.05 | Comparative efficacy of ibuprofen, indomethacin, and placebo in the treatment of primary dysmenorrhea. ( Forman, ES; Gookin, KS; Morrison, JC; Vecchio, TJ; Wiser, WL, 1983) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 9.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "This prospective, double-blind, parallel, two clinic study compared fenoprofen calcium, 200 mg; ibuprofen, 400 mg; and placebo in the treatment of pain due to primary dysmenorrhea." | 9.05 | Comparison of fenoprofen calcium, ibuprofen and placebo in primary dysmenorrhea. ( Arnold, JD; Burt, RA; Gruber, CM; Iber, FL, 1983) |
| "The efficacy of ibuprofen and naproxen-sodium for the treatment of primary dysmenorrhea was evaluated in a double-blind cross-over study in 57 otherwise healthy women." | 9.05 | Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study. ( Andersch, B; Milsom, I, 1985) |
| "The prostaglandin synthetase inhibitor ibuprofen was evaluated for relief of severe primary dysmenorrhea in a controlled, double-blind, cross-over study in seven patients for a total of 23 menstrual cycles." | 9.04 | Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid. ( Chan, WY; Dawood, MY; Fuchs, F, 1979) |
| "We included randomised, double-blind studies that compared a single dose of analgesic plus caffeine with the same dose of the analgesic alone in the treatment of acute pain." | 8.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "An open, prospective study, including 15 young women with primary dysmenorrhea was carried out to asses the prophylactic administration of Ibuprofen for the treatment of severe and disabling primary dysmenorrhea." | 7.70 | [Preventive treatment of primary dysmenorrhea with ibuprofen]. ( González-Unzaga, M; Medina Santillan, R; Pedrón Nuevo, N, 1998) |
| "A double-blind three-way crossover design in the treatment of dysmenorrhea comparing a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) with a placebo showed that both ibuprofen and mefenamic acid are generally superior to placebo." | 7.66 | A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea. ( Roy, S, 1983) |
| " The intended dosage was 2 tablets every 4 hours as necessary for relief of menstrual pain." | 6.64 | Ibuprofen therapy for dysmenorrhea. ( Bolognese, RJ; Corson, SL, 1978) |
| "Eryngo relieved dysmenorrhea as effectively as Ibuprofen did." | 5.30 | Effect of eryngo (Eryngium caucasicum Trautv) on primary dysmenorrhea: A randomized, double-blind, placebo-controlled study. ( Behmanesh, E; Delavar, MA; Kamalinejad, M; Khafri, S; Mozaffarpur, SA; Shirafkan, H, 2019) |
| "Ibuprofen was free of side effects, but four patients had headaches or peculiar psychic effects on indomethacin." | 5.26 | A clinical trial of indomethacin and ibuprofen in dysmenorrhea. ( Demers, LM; Halbert, DR, 1978) |
| " The secondary outcomes were measured by the duration of relief from dysmenorrheal pain, number of ibuprofen tablets taken, and the World Health Organization quality of life (WHOQOL)-BREF score, as well as the adverse events." | 5.24 | Effect of transcutaneous electrical nerve stimulation therapy for the treatment of primary dysmenorrheal. ( Bai, HY; Yang, ZQ, 2017) |
| "Needling and ibuprofen are often used clinically to treat primary dysmenorrhea (PD)." | 5.22 | The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen: A systematic review and meta-analysis. ( Cao, Q; Fu, Y; Huang, Y; Li, L; Liu, D; Xuan, Y; Zhang, H, 2022) |
| "Study was planned to evaluate the efficacy and safety of lornoxicam in moderate to severe menstrual pain due to primary dysmenorrhea." | 5.20 | Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study. ( Acharya, H; Nakum, K; Patel, JC; Patel, PB; Tripathi, CB, 2015) |
| "Assess the efficacy and safety of etoricoxib 120 mg compared with ibuprofen 600 mg qid in the treatment of moderate to severe primary dysmenorrhea in Chinese women." | 5.19 | Etoricoxib in the treatment of primary dysmenorrhea in Chinese patients: a randomized controlled trial. ( Chang, Q; Di, W; Hua, Q; Li, X; Liu, J; Mehta, A; Yan, L; Yao, Y; Yu, Q; Yu, W; Zhang, X; Zhang, Y; Zhu, X; Zou, Q, 2014) |
| "Preliminary evaluation of efficacy and safety of uzara use in treatment of moderate and severe primary dysmenorrhea in comparison to ibuprofen." | 5.19 | A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea. ( Abd-El-Maeboud, KH; Ali, MS; Ibrahim, MI; Kortam, MA; Mohamed, RM, 2014) |
| "Heat patch containing Iron chip has comparable analgesic effects to ibuprofen and can possibly be used for primary dysmenorrhea." | 5.16 | Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial. ( Kermansaravi, F; Khazaian, S; Navidian, A; Navvabi Rigi, S; Safabakhsh, L; Safarzadeh, A; Salehian, T; Shafie, S, 2012) |
| "Ginger was as effective as mefenamic acid and ibuprofen in relieving pain in women with primary dysmenorrhea." | 5.14 | Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea. ( Goli, M; Moattar, F; Ozgoli, G, 2009) |
| "In patients experiencing acute visceral pain as a result of primary dysmenorrhea, dexibuprofen was associated with a dose-dependent effective analgesia; this effect was at least equivalent to that of the double dose of ibuprofen." | 5.14 | ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial. ( Kaehler, ST; Kollenz, C; Phleps, W, 2009) |
| "Mild moxibustion cannot only effectively treat PD but also relieve pain in comparison with ibuprofen." | 5.12 | Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients with dysmenorrhea: A systematic review and network meta-analysis. ( Cai, MJ; Chen, JY; Huang, PD; Huang, XY; Lv, ZH; Wu, ZX, 2021) |
| "The purpose of this study was to compare acetaminophen with ibuprofen for pain relief and menstrual fluid prostaglandin F2alpha (PGF2alpha) suppression in primary dysmenorrhea." | 5.12 | Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea. ( Dawood, MY; Khan-Dawood, FS, 2007) |
| "The present study aims at comparing the effects of acupressure using new combination of acupoints, and Ibuprofen on the severity of primary dysmenorrhea (PD)." | 5.10 | Effects of acupressure and ibuprofen on the severity of primary dysmenorrhea. ( Ibrahimzadeh, R; Pouresmail, Z, 2002) |
| " Naproxen 400 mg provided greater pain relief than acetaminophen and placebo within 30 minutes of administration (P < 0." | 5.10 | Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies. ( Akin, MD; Dawood, MY; Milsom, I; Minic, M; Niland, NF; Spann, J; Squire, RA, 2002) |
| "Continuous low-level topical heat therapy was as effective as ibuprofen for the treatment of dysmenorrhea." | 5.09 | Continuous low-level topical heat in the treatment of dysmenorrhea. ( Akin, MD; Goodale, MB; Hengehold, DA; Hinkle, RT; Smith, RP; Weingand, KW, 2001) |
| "In double-blind studies, mefenamic acid (group A) was compared with ibuprofen (group B) in the treatment of primary dysmenorrhea in 60 patients, during two cycles." | 5.08 | [Treatment of primary dysmenorrhea. Comparative study of ibuprofen and mefenamic acid]. ( Pedrón Nuevo, DN, 1995) |
| "Sixty female out-patients suffering from moderate to severe primary dysmenorrhea, aged 14-40 years (mean 27 years), entered this randomized, double-blind, 3-period, within-patient study, evaluating the efficacy and tolerability of diclofenac dispersible 46." | 5.08 | Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study. ( Bakshi, R; Fedele, L; Marchini, M; Pistai, R; Tozzi, L, 1995) |
| "In a randomized four-way crossover study, 32 women with primary dysmenorrhea were treated with transcutaneous electrical nerve stimulation (TENS) for two cycles, placebo (sham) TENS for one cycle, or ibuprofen 400 mg four times a day for one cycle." | 5.06 | Transcutaneous electrical nerve stimulation (TENS) for the treatment of primary dysmenorrhea: a randomized crossover comparison with placebo TENS and ibuprofen. ( Dawood, MY; Ramos, J, 1990) |
| "Under double-blind, crossover conditions, 43 women with primary dysmenorrhea received ketoprofen, ibuprofen, and placebo during three consecutive menstrual cycles." | 5.06 | Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison. ( Mehlisch, DR, 1988) |
| "Considering the efficacy and safety, ibuprofen is recommended as the optimal OTCA for primary dysmenorrhea." | 5.05 | Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis. ( Chen, Y; Hao, C; Nie, W; Wang, L; Xu, P; Yin, Y, 2020) |
| "This prospective, double-blind, parallel, two clinic study compared fenoprofen calcium, 200 mg; ibuprofen, 400 mg; and placebo in the treatment of pain due to primary dysmenorrhea." | 5.05 | Comparison of fenoprofen calcium, ibuprofen and placebo in primary dysmenorrhea. ( Arnold, JD; Burt, RA; Gruber, CM; Iber, FL, 1983) |
| "Forty-two women with primary dysmenorrhea were successfully enrolled in a double-blind, three-way crossover study in which each patient received either ibuprofen (Motrin), indomethacin (Indocin), or a placebo during each of three successive painful menstrual cycles." | 5.05 | Comparative efficacy of ibuprofen, indomethacin, and placebo in the treatment of primary dysmenorrhea. ( Forman, ES; Gookin, KS; Morrison, JC; Vecchio, TJ; Wiser, WL, 1983) |
| "The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study." | 5.05 | Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea. ( Andersch, B; Milsom, I, 1984) |
| "Fifty-five women with primary dysmenorrhea were enrolled in a study which each took ibuprofen (400 mg), propoxyphene hydrochloride (64 mg), or a placebo alternately in consecutive menstrual cycles for relief of pain." | 5.05 | Analgesic efficacy of ibuprofen for treatment of primary dysmenorrhea. ( Bates, GW; Blake, PG; Forman, EK; Linden, CV; Ling, FW; Morrison, JC; O'Connell, MJ; Vecchio, TJ, 1980) |
| "The efficacy of ibuprofen and naproxen-sodium for the treatment of primary dysmenorrhea was evaluated in a double-blind cross-over study in 57 otherwise healthy women." | 5.05 | Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study. ( Andersch, B; Milsom, I, 1985) |
| "The prostaglandin synthetase inhibitor ibuprofen was evaluated for relief of severe primary dysmenorrhea in a controlled, double-blind, cross-over study in seven patients for a total of 23 menstrual cycles." | 5.04 | Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid. ( Chan, WY; Dawood, MY; Fuchs, F, 1979) |
| "We included randomised, double-blind studies that compared a single dose of analgesic plus caffeine with the same dose of the analgesic alone in the treatment of acute pain." | 4.90 | Caffeine as an analgesic adjuvant for acute pain in adults. ( Derry, CJ; Derry, S; Moore, RA, 2014) |
| "Primary dysmenorrhea is a common disease in women, and oral administration of Ibuprofen (IBU) is associated with first-pass effects and gastrointestinal irritation." | 4.31 | Transdermal administration of ibuprofen-loaded hexagonal liquid crystal gel for enhancement of drug concentration in the uterus: in vitro and in vivo evaluation. ( Chen, J; Cheng, WK; Chu, XQ; Liu, L; Tian, CL; Xia, MQ; Zheng, Z, 2023) |
| "An open, prospective study, including 15 young women with primary dysmenorrhea was carried out to asses the prophylactic administration of Ibuprofen for the treatment of severe and disabling primary dysmenorrhea." | 3.70 | [Preventive treatment of primary dysmenorrhea with ibuprofen]. ( González-Unzaga, M; Medina Santillan, R; Pedrón Nuevo, N, 1998) |
| "A double-blind three-way crossover design in the treatment of dysmenorrhea comparing a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) with a placebo showed that both ibuprofen and mefenamic acid are generally superior to placebo." | 3.66 | A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea. ( Roy, S, 1983) |
| "To explore the effects of modified Wenjing decoction combined with online publicity and education on the treatment of primary dysmenorrhea of cold coagulation and blood stasis." | 3.11 | Effects of Modified Wenjing Decoction Combined with Online Publicity and Education on the Treatment of Primary Dysmenorrhea of Cold Coagulation and Blood Stasis. ( Gai, P; Li, J; Li, N, 2022) |
| "The primary outcome was the intensity of menstrual pain measured by using the visual analogue scale at the completion of treatment." | 2.90 | Effect of an Acupuncture Technique of Penetrating through ( Cao, Y; Ji, L; Jin, X; Li, R; Wang, H; Wang, J; Yan, M, 2019) |
| "Both drugs reduced menstrual pain." | 2.87 | Effect of Ginger and Novafen on menstrual pain: A cross-over trial. ( Adib Rad, H; Bakouei, F; Basirat, Z; Farhadi Kotenaei, Z; Kazemi, S; Khafri, S; Moghadamnia, AA; Nikpour, M, 2018) |
| "Treatment with mefenamic acid resulted in less volume of blood loss compared to tranexamic acid (MD -64." | 2.82 | Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use. ( Christelle, K; Jaafar, SH; Norhayati, MN, 2022) |
| "Ibuprofen was more efficient and the effect was faster, than drotaverine in relieving pain in dysmenorrhoea." | 2.73 | [Comparative efficacy and tolerability of drotaverine 80 mg and ibuprofen 400 mg in patients with primary dysmenorrhoea--protocol DOROTA]. ( Debska, M; Debski, R; Mazurek, M; Niemiec, T, 2007) |
| "The intensity of menstrual pain remained unchanged in controls upon admission (3." | 2.69 | [Menstrual prostaglandin and dysmenorrhea: modulation by non-steroidal antiinflammatory drugs]. ( de los Santos, AR; Di Girolamo, G; Faletti, A; Gimeno, MA; Martí, ML; Zmijanovich, R, 1999) |
| " This drug was highly effective when given in a dosage of one 400mg tablet at the first sign of pain or bleeding followed by further 400mg tablets every 4 to 6 hours for the duration of expected symptoms." | 2.66 | Ibuprofen is a useful treatment for primary dysmenorrhoea. ( Fraser, IS; McCarron, G, 1987) |
| "Ibuprofen was significantly more effective in 18 patients when compared to the other 2 treatment regimens (P less than 0." | 2.65 | Dysmenorrhea: treatment with an antiprostaglandin. ( Larkin, RM; Poulson, AM; Scott, JR; Van Orden, DE, 1979) |
| "Ibuprofen also reduced the menstrual pain significantly (P less than 0." | 2.65 | Effect of ibuprofen on menstrual blood prostaglandin levels in dysmenorrheic women. ( Csapo, AI; Pulkkinen, MO, 1979) |
| " The intended dosage was 2 tablets every 4 hours as necessary for relief of menstrual pain." | 2.64 | Ibuprofen therapy for dysmenorrhea. ( Bolognese, RJ; Corson, SL, 1978) |
| "In addition, menstrual pain was significantly reduced (P." | 2.64 | The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients. ( Csapo, AI; Pulkkinen, MO, 1978) |
| "Primary dysmenorrhea is painful menstrual cramps without any evident pathology to account for them, and it occurs in up to 50% of menstruating females and causes significant disruption in quality of life and absenteeism." | 2.43 | Primary dysmenorrhea: advances in pathogenesis and management. ( Dawood, MY, 2006) |
| "5:1, dexibuprofen was found to be at least as efficacious as racemic ibuprofen; 75% of the maximum daily dose of dexibuprofen was equally efficacious as 100% of MDD of diclofenac; no influence was found of meals on bioavailability and a significant doseresponse relationship; there was clinical efficacy in rheumatoid arthritis, ankylosing spondylitis, osteoarthritis of the hip, osteoarthritis of the knee, lumbar vertebral syndrome, distortion of the ankle joint and dysmenorrhoea; there was good tolerability compared to other NSAIDs: racemic ibuprofen showed a 30% and diclofenac a 90% higher incidence of adverse drug reactions; the long-term study stated a 15." | 2.41 | Overview on clinical data of dexibuprofen. ( Phleps, W, 2001) |
| "Young women with Rett syndrome have standard symptoms of dysmenorrhea and PMS as well as autism spectrum specific PMS symptoms." | 1.38 | Rett syndrome and menstruation. ( Hamilton, A; Marshal, MP; Murray, PJ; Sucato, GS, 2012) |
| "Suprofen is a non-narcotic, peripheral analgesic that exhibits potent prostaglandin (PG) synthesis inhibitory activities in a variety of subcellular tissue preparations and in vivo." | 1.27 | Potent and selective effects of suprofen on uterine prostaglandin synthesis. ( Fuller, BL; Rosenthale, ME; Tolman, EL, 1985) |
| "Ibuprofen was free of side effects, but four patients had headaches or peculiar psychic effects on indomethacin." | 1.26 | A clinical trial of indomethacin and ibuprofen in dysmenorrhea. ( Demers, LM; Halbert, DR, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (47.13) | 18.7374 |
| 1990's | 6 (6.90) | 18.2507 |
| 2000's | 13 (14.94) | 29.6817 |
| 2010's | 18 (20.69) | 24.3611 |
| 2020's | 9 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Li, N | 1 |
| Li, J | 1 |
| Gai, P | 1 |
| Xuan, Y | 1 |
| Zhang, H | 2 |
| Liu, D | 1 |
| Huang, Y | 1 |
| Li, L | 1 |
| Cao, Q | 1 |
| Fu, Y | 1 |
| Quintão, NLM | 2 |
| Reis, JP | 2 |
| Benvenutti, L | 1 |
| Nunes, R | 1 |
| Goldoni, FC | 1 |
| Cozer, MS | 1 |
| de Souza, P | 1 |
| de Cássia Melo Vilhena de Andrade Fonseca da Silva, R | 1 |
| Melato, J | 1 |
| Vaz, CR | 1 |
| Whitaker, JCP | 2 |
| Jesuíno, FW | 1 |
| Costa, MC | 1 |
| Pastor, MVD | 2 |
| Malheiros, A | 1 |
| Meyre-Silva, C | 1 |
| Santin, JR | 1 |
| Christelle, K | 1 |
| Norhayati, MN | 1 |
| Jaafar, SH | 1 |
| Xia, MQ | 1 |
| Chen, J | 2 |
| Liu, L | 1 |
| Tian, CL | 1 |
| Cheng, WK | 1 |
| Zheng, Z | 1 |
| Chu, XQ | 1 |
| Nuha, K | 1 |
| Rusmil, K | 1 |
| Ganiem, AR | 1 |
| Permadi, W | 1 |
| Diah Herawati, DM | 1 |
| Wang, H | 1 |
| Cao, Y | 1 |
| Jin, X | 1 |
| Yan, M | 1 |
| Wang, J | 1 |
| Li, R | 1 |
| Ji, L | 1 |
| Nie, W | 1 |
| Xu, P | 1 |
| Hao, C | 1 |
| Chen, Y | 2 |
| Yin, Y | 1 |
| Wang, L | 1 |
| Chen, LF | 1 |
| Jin, XF | 1 |
| Li, BW | 1 |
| Zhan, MJ | 1 |
| Hu, HT | 1 |
| Wu, ZX | 1 |
| Cai, MJ | 1 |
| Huang, PD | 1 |
| Chen, JY | 1 |
| Lv, ZH | 1 |
| Huang, XY | 1 |
| Bai, HY | 2 |
| Yang, ZQ | 1 |
| Barassi, G | 1 |
| Bellomo, RG | 1 |
| Porreca, A | 1 |
| Di Felice, PA | 1 |
| Prosperi, L | 1 |
| Saggini, R | 1 |
| Jesuíno, FWDR | 1 |
| Campos, A | 1 |
| Cechinel Filho, V | 1 |
| Adib Rad, H | 1 |
| Basirat, Z | 1 |
| Bakouei, F | 1 |
| Moghadamnia, AA | 1 |
| Khafri, S | 2 |
| Farhadi Kotenaei, Z | 1 |
| Nikpour, M | 1 |
| Kazemi, S | 1 |
| Behmanesh, E | 1 |
| Delavar, MA | 1 |
| Kamalinejad, M | 1 |
| Shirafkan, H | 1 |
| Mozaffarpur, SA | 1 |
| Desai, NC | 1 |
| English, JC | 1 |
| Witt, J | 1 |
| Strickland, J | 1 |
| Cheng, AL | 1 |
| Curtis, C | 1 |
| Calkins, J | 1 |
| Yu, Q | 1 |
| Zhu, X | 1 |
| Zhang, X | 1 |
| Zhang, Y | 1 |
| Li, X | 1 |
| Hua, Q | 1 |
| Chang, Q | 1 |
| Zou, Q | 1 |
| Di, W | 1 |
| Yao, Y | 1 |
| Yu, W | 1 |
| Liu, J | 1 |
| Mehta, A | 1 |
| Yan, L | 1 |
| Abd-El-Maeboud, KH | 1 |
| Kortam, MA | 1 |
| Ali, MS | 1 |
| Ibrahim, MI | 1 |
| Mohamed, RM | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Cross-Over Study of the Use of Transcutaneous Electrical Nerve Stimulation Unit in the Management of Endometriosis Pain[NCT05348005] | 40 participants (Anticipated) | Interventional | 2022-07-28 | Recruiting | |||
| A Phase III, Randomized, Active-Comparator-Controlled, 2-period, Crossover, Double-Blind Study in China to Assess the Safety and Efficacy of Etoricoxib 120 mg Versus Ibuprofen up to 2400 mg (600 mg Q6h) in the Treatment of Patients With Primary Dysmenorrh[NCT01462370] | Phase 3 | 139 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
| A Randomized, Crossover, Pilot Trial of the Feasibility and Safety of Acupoint Injection of Vitamin K for Treatment of Primary Dysmenorrhea[NCT00995917] | 18 participants (Actual) | Interventional | 2009-10-31 | Completed | |||
| Effect of Auriculotherapy in the Treatment of Dysmenorrhea: Protocol of a Randomized Controlled Clinical Trial[NCT03148223] | 74 participants (Actual) | Interventional | 2017-05-15 | Completed | |||
| Examining the Role of Improved NSAID Management in Treating Dysmenorrhea and Bladder Pain[NCT03697720] | Phase 4 | 26 participants (Actual) | Interventional | 2018-05-09 | Completed | ||
| Assessment of Mediacal Taping Concept Self-applied, in the Treatment of Primary Dysmenorrhea[NCT02114723] | 129 participants (Actual) | Interventional | 2014-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The GLOBAL24 was recorded by the participant at 24 hours (or at the time of rescue medication use) after taking the first dose of study medication. The GLOBAL24 uses a pain relief scale of 0 to 4, where 0 = poor pain relief, 1 = fair pain relief, 2 = good pain relief, 3 = very good pain relief, and 4 = excellent pain relief. (NCT01462370)
Timeframe: 24 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 2.65 |
| Ibuprofen up to 2400 mg | 2.29 |
The GLOBAL6 was recorded by the participant at 6 hours (or at the time of rescue medication use) after taking the first dose of study medication. The GLOBAL6 uses a pain relief scale of 0 to 4, where 0 = poor pain relief, 1 = fair pain relief, 2 = good pain relief, 3 = very good pain relief, and 4 = excellent pain relief. (NCT01462370)
Timeframe: 6 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 2.50 |
| Ibuprofen up to 2400 mg | 2.24 |
The time to a change from baseline in pain intensity score of >=1 unit on the pain intensity scale was calculated. The pain intensity scale rates participant pain on a scale of -1 to 3, with larger values associated with greater treatment effect. (NCT01462370)
Timeframe: Baseline and 6 hours
| Intervention | Hours (Mean) |
|---|---|
| Etoricoxib 120 mg | 1.0 |
| Ibuprofen up to 2400 mg | 1.5 |
Acetaminophen 250 mg, isopropylantipyrine 150 mg and anhydrous caffeine 50 mg (Saridon) was provided to each participant as rescue medication. Participants were permitted to take 2 tablets at a time and up to 3 doses within 24 hours of dosing of study drug for rescue purposes. (NCT01462370)
Timeframe: 24 Hours
| Intervention | Participants (Number) |
|---|---|
| Etoricoxib 120 mg | 1 |
| Ibuprofen up to 2400 mg | 4 |
At 24 hours following the initial dose of study medication, participants were asked to rate their perception of pain control as poor, fair, good, very good, or excellent. The number of participants that reported good, very good, or excellent pain control at 24 hours post initial dose were summed. (NCT01462370)
Timeframe: 24 Hours
| Intervention | Participants (Number) |
|---|---|
| Etoricoxib 120 mg | 113 |
| Ibuprofen up to 2400 mg | 101 |
At 6 hours following the initial dose. participants were asked to rate their perception of pain control as poor, fair, good, very good, or excellent. The number of participants that reported good, very good, or excellent pain control at 6 hours post initial dose were summed. (NCT01462370)
Timeframe: 6 hours
| Intervention | Participants (Number) |
|---|---|
| Etoricoxib 120 mg | 111 |
| Ibuprofen up to 2400 mg | 103 |
Peak PID during the 6 hours post initial dose is defined as the maximum PID score recorded during first 6 hours after the initial dose of study medication. PID is evaluated on a scale of -1 to 3, with larger values representing a greater treatment effect. (NCT01462370)
Timeframe: Baseline and 0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 2.2 |
| Ibuprofen up to 2400 mg | 2.1 |
"Peak PR during the 6 hours post initial dose is defined as the maximum PR score~recorded during the first 6 hours after the initial dose of study medication. PR is recorded on a scale of 0 to 4, with 0 = no pain relief, 1 = little pain relief, 2 = some pain relief, 3 = a lot of pain relief, and 4 = complete pain relief." (NCT01462370)
Timeframe: Up to 6 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 3.70 |
| Ibuprofen up to 2400 mg | 3.52 |
PID during the 12 hours following the initial dose is defined as the maximum PID score recorded during first 12 hours after the initial dose of study medication. PID is evaluated on a scale from 0 to 3, with 0 = no pain, 1 = slight pain, 2 = moderate pain, and 3 = severe pain. (NCT01462370)
Timeframe: Baseline and 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8 and 12 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 2.28 |
| Ibuprofen up to 2400 mg | 2.07 |
PID during the 24 hours following the initial dose is defined as the maximum PID score recorded during first 24 hours after the initial dose of study medication. PID is evaluated on a scale from 0 to 3, with 0 = no pain, 1 = slight pain, 2 = moderate pain, and 3 = severe pain. (NCT01462370)
Timeframe: Baseline and 0.5, 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 12, 20 and 24 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 2.36 |
| Ibuprofen up to 2400 mg | 2.25 |
PR during the 12 hours following the initial dose is defined as the maximum PR score recorded during the first 12 hours after the initial dose of study medication. PR is evaluated on a scale of 0 to 4, with 0 = no pain relief, 1= a little pain relief, 2 = some pain relief, 3 = a lot of pain relief, and 4 = complete pain relief. (NCT01462370)
Timeframe: Up to 12 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 3.73 |
| Ibuprofen up to 2400 mg | 3.45 |
PR during the 24 hours following the initial dose is defined as the maximum PR score recorded during the first 24 hours after the initial dose of study medication. PR is evaluated on a scale of 0 to 4, with 0 = no pain relief, 1= a little pain relief, 2 = some pain relief, 3 = a lot of pain relief, and 4 = complete pain relief. (NCT01462370)
Timeframe: Up to 24 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 3.88 |
| Ibuprofen up to 2400 mg | 3.62 |
The Pain Intensity Difference (PID) score is the difference between the baseline pain intensity (PI) score and the PI score recorded at each time point post initial dose, as calculated by subtracting the pain intensity at each of the subsequent time points from the baseline pain intensity score; therefore, it is on a -1 to 3 scale, with a large value representing a greater treatment effect. SPID6 is derived by multiplying the PID score at each time point by the duration (in hours) since the preceding time point, and summing these weighted values up to 6 hours and it is on a scale of -6 to 18. (NCT01462370)
Timeframe: Baseline and 0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 9.48 |
| Ibuprofen up to 2400 mg | 9.27 |
TOPAR6 was calculated by multiplying the pain relief (PR) score (0- to 4-point scale, with 0=None, and 4=Complete for pain relief) at each time point by the duration (in hours) since the preceding time point, and summing these weighted values up to 6 hours post the initial Day 1 dose. The range of TOPAR6 score is 0 to 24, with increasing scores indicating greater pain relief. (NCT01462370)
Timeframe: Baseline and 0.5, 1, 1.5, 2, 3, 4, 5 and 6 hours
| Intervention | Score on a Scale (Least Squares Mean) |
|---|---|
| Etoricoxib 120 mg | 17.38 |
| Ibuprofen up to 2400 mg | 16.49 |
Score on a scale. Specifically, we used a Numeric Rating Scale (NRS)- 0 through 10 scale with 0 being no pain and 10 worst pain imaginable. Results for the worst menstrual pain score on an NRS from the 6-8 mth menstrual pain diary will be compared to baseline pretreatment diary worst pain score. (NCT03697720)
Timeframe: 6-8 months
| Intervention | score on a scale (Mean) |
|---|---|
| Primary Dysmenorrhea | 4.1 |
Score on a scale. Specifically, we used a Visual Analog Scale- 0 through 100 scale with 0 being no pain and 100 worst pain imaginable. Results from the visual analog scale (VAS) of the bladder filling test at the baseline and 6-8 mph followup visit will be compared to determine if naproxen treatment of menstrual pain affected bladder pain. Bladder pain ratings at first urge will be used at the outcome measure. (NCT03697720)
Timeframe: 6-8 months
| Intervention | score on a scale (Mean) |
|---|---|
| Primary Dysmenorrhea | 10.7 |
13 reviews available for ibuprofen and Dysmenorrhea
| Article | Year |
|---|---|
The efficacy and safety of simple-needling for the treatment of primary dysmenorrhea compared with ibuprofen: A systematic review and meta-analysis.
Topics: Dysmenorrhea; Female; Humans; Ibuprofen; Treatment Outcome; Vascular Surgical Procedures | 2022 |
Interventions to prevent or treat heavy menstrual bleeding or pain associated with intrauterine-device use.
Topics: Acetaminophen; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dysmenorrhea; Female; Hum | 2022 |
Efficacy and safety of over-the-counter analgesics for primary dysmenorrhea: A network meta-analysis.
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Diclofenac; Dysmeno | 2020 |
Comparative efficacy and dysmenorrhea score of 6 object-separated moxibustions for the treatment of Chinese patients with dysmenorrhea: A systematic review and network meta-analysis.
Topics: Analgesics, Non-Narcotic; Bayes Theorem; China; Dysmenorrhea; Female; Humans; Ibuprofen; Moxibustion | 2021 |
Caffeine as an analgesic adjuvant for acute pain in adults.
Topics: Acetaminophen; Acute Pain; Adolescent; Adult; Aged; Analgesics; Caffeine; Chemotherapy, Adjuvant; Di | 2014 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Primary dysmenorrhea: advances in pathogenesis and management.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral, Combined; Decision Trees; Dysmenorrhe | 2006 |
Prostaglandins and nonsteroidal antiinflammatory drugs in dysmenorrhea.
Topics: Anti-Inflammatory Agents; Aspirin; Contraceptives, Oral; Dysmenorrhea; Female; Humans; Ibuprofen; In | 1983 |
Current status of the etiology and management of dysmenorrhea in adolescence.
Topics: Adolescent; Aspirin; Contraceptives, Oral; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; | 1982 |
Primary dysmenorrhea treatment with prostaglandin inhibitors: a review.
Topics: Adolescent; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Middle Aged; Naproxen; ort | 1981 |
Efficacy of minor analgesics in primary dysmenorrhoea: a systematic review.
Topics: Acetaminophen; Adolescent; Adult; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, No | 1998 |
Overview on clinical data of dexibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Digestive System; Dysmenorrhea; Female; Humans; Ibuprofen; | 2001 |
[Dysmenorrhea in the female adolescent. Clinical, biological and therapeutic data].
Topics: Adolescent; Dinoprost; Dysmenorrhea; Female; France; Humans; Ibuprofen; Indomethacin; ortho-Aminoben | 1986 |
49 trials available for ibuprofen and Dysmenorrhea
| Article | Year |
|---|---|
Effects of Modified Wenjing Decoction Combined with Online Publicity and Education on the Treatment of Primary Dysmenorrhea of Cold Coagulation and Blood Stasis.
Topics: Analgesics; Drugs, Chinese Herbal; Dysmenorrhea; Female; Humans; Ibuprofen; Retrospective Studies | 2022 |
Single-Blind Randomized Controlled Trial: Comparative Efficacy of Dark Chocolate, Coconut Water, and Ibuprofen in Managing Primary Dysmenorrhea.
Topics: Chocolate; Cocos; Dysmenorrhea; Female; Humans; Ibuprofen; Single-Blind Method | 2023 |
Effect of an Acupuncture Technique of Penetrating through
Topics: Acupuncture Therapy; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Humans; Ibuprofen; Needl | 2019 |
[Herb-separated moxibustion on dysmenorrhea in ovarian endometriosis: a randomized controlled trial].
Topics: Acupuncture Points; Dysmenorrhea; Endometriosis; Female; Humans; Ibuprofen; Moxibustion; Ovary | 2020 |
Effect of transcutaneous electrical nerve stimulation therapy for the treatment of primary dysmenorrheal.
Topics: Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Female; Humans; Ibuprofen; Pain Management; Pain Meas | 2017 |
Somato-Visceral Effects in the Treatment of Dysmenorrhea: Neuromuscular Manual Therapy and Standard Pharmacological Treatment.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dysmenorrhea; Female; Humans; Ibuprofen; Musculoskeletal Ma | 2018 |
Effect of Ginger and Novafen on menstrual pain: A cross-over trial.
Topics: Acetaminophen; Adolescent; Adult; Caffeine; Cross-Over Studies; Drug Combinations; Dysmenorrhea; Fem | 2018 |
Effect of eryngo (Eryngium caucasicum Trautv) on primary dysmenorrhea: A randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Dysmenorrhea; Eryngium; Female; Hu | 2019 |
A randomized trial comparing the VIPON tampon and ibuprofen for dysmenorrhea pain relief.
Topics: Adult; Analgesics, Non-Narcotic; Dose-Response Relationship, Drug; Dysmenorrhea; Female; Humans; Ibu | 2013 |
Etoricoxib in the treatment of primary dysmenorrhea in Chinese patients: a randomized controlled trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; China; Cross-Over Studies; Cyclooxygenase 2 Inhibito | 2014 |
A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea.
Topics: Adult; Apocynaceae; Cross-Over Studies; Dysmenorrhea; Egypt; Female; Humans; Ibuprofen; Pain Measure | 2014 |
Efficacy and safety of lornoxicam vs ibuprofen in primary dysmenorrhea: a randomized, double-blind, double dummy, active-controlled, cross over study.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; Dysmen | 2015 |
ADIDAC trial: analgesia with dexibuprofen versus ibuprofen in patients suffering from primary dysmenorrhea: a crossover trial.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Dose-Response Relationship, Drug | 2009 |
A comparative study of injection placentrex and conventional therapy in treatment of pelvic inflammatory disease.
Topics: Abdominal Pain; Adnexal Diseases; Adult; Alkylating Agents; Anti-Bacterial Agents; Anti-Infective Ag | 2008 |
Comparison of effects of ginger, mefenamic acid, and ibuprofen on pain in women with primary dysmenorrhea.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Dysmenorrhea; Female; Humans; I | 2009 |
A double-blind, randomised, crossover study of two doses of a single-tablet combination of ibuprofen/paracetamol and placebo for primary dysmenorrhoea.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double-Blind Method; | 2010 |
[Effect of massage on hemodynamics parameters of uterine artery and serum prostaglandin in treating patients with primary dysmenorrhea].
Topics: Adolescent; Adult; Blood Flow Velocity; Dysmenorrhea; Female; Hemodynamics; Humans; Ibuprofen; Massa | 2011 |
Effect of omega-3 fatty acids on intensity of primary dysmenorrhea.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Dietary Supplements; Double-Blind M | 2012 |
Comparing the analgesic effect of heat patch containing iron chip and ibuprofen for primary dysmenorrhea: a randomized controlled trial.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Dysmenorrhea; Emotions; Female; Humans; Hyperthermia, I | 2012 |
Comparison of the efficacy and safety of nonprescription doses of naproxen and naproxen sodium with ibuprofen, acetaminophen, and placebo in the treatment of primary dysmenorrhea: a pooled analysis of five studies.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over | 2002 |
Effects of acupressure and ibuprofen on the severity of primary dysmenorrhea.
Topics: Acupressure; Acupuncture Points; Adolescent; Dysmenorrhea; Female; Humans; Ibuprofen | 2002 |
Effect of a Psidii guajavae folium extract in the treatment of primary dysmenorrhea: a randomized clinical trial.
Topics: Adolescent; Adult; Analgesics, Non-Narcotic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibup | 2007 |
Clinical efficacy and differential inhibition of menstrual fluid prostaglandin F2alpha in a randomized, double-blind, crossover treatment with placebo, acetaminophen, and ibuprofen in primary dysmenorrhea.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Body Fluids; Cross-Over Studies; Dinoprost; Double-B | 2007 |
[Comparative efficacy and tolerability of drotaverine 80 mg and ibuprofen 400 mg in patients with primary dysmenorrhoea--protocol DOROTA].
Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double | 2007 |
Comparative efficacy of ibuprofen, indomethacin, and placebo in the treatment of primary dysmenorrhea.
Topics: Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibup | 1983 |
Comparison of fenoprofen calcium, ibuprofen and placebo in primary dysmenorrhea.
Topics: Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Fenoprofen; Humans; Ibuprofen; | 1983 |
Mefenamic acid, ibuprofen, and dysmenorrhea.
Topics: Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Ac | 1984 |
Ibuprofen and dysmenorrhea.
Topics: Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Intrauterine | 1984 |
Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
Topics: Acetaminophen; Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; I | 1984 |
Prostaglandin synthetase inhibitors in the treatment of primary dysmenorrhea. Outcome trials reviewed.
Topics: Clinical Trials as Topic; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Flufenamic Acid; Humans; | 1984 |
Differential effects of ibuprofen and naproxen sodium on menstrual prostaglandin release and on prostaglandin production in the rat uterine homogenate.
Topics: Animals; Cell-Free System; Dysmenorrhea; Female; Humans; Ibuprofen; Menstruation; Naproxen; Prostagl | 1984 |
Analgesic efficacy of ibuprofen for treatment of primary dysmenorrhea.
Topics: Adult; Clinical Trials as Topic; Dextropropoxyphene; Double-Blind Method; Dysmenorrhea; Female; Huma | 1980 |
Prostaglandins in primary dysmenorrhea. Comparison of prophylactic and nonprophylactic treatment with ibuprofen and use of oral contraceptives.
Topics: Adult; Clinical Trials as Topic; Contraceptives, Oral; Double-Blind Method; Dysmenorrhea; Female; Hu | 1981 |
[Treatment of primary dysmenorrhea. Comparative study of ibuprofen and mefenamic acid].
Topics: Adolescent; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Pai | 1995 |
Comparative efficacy of diclofenac dispersible 50 mg and ibuprofen 400 mg in patients with primary dysmenorrhea. A randomized, double-blind, within-patient, placebo-controlled study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 1995 |
[Menstrual prostaglandin and dysmenorrhea: modulation by non-steroidal antiinflammatory drugs].
Topics: Adolescent; Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Clonixin; Double-Blind Metho | 1999 |
Continuous low-level topical heat in the treatment of dysmenorrhea.
Topics: Adult; Analgesics, Non-Narcotic; Double-Blind Method; Dysmenorrhea; Female; Hot Temperature; Humans; | 2001 |
Prostaglandin synthetase inhibitors and dysmenorrhea. A survey and personal clinical experience.
Topics: Adolescent; Adult; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Ev | 1979 |
Ibuprofen therapy for dysmenorrhea.
Topics: Adult; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female | 1978 |
The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrheic patients.
Topics: Administration, Oral; Adult; Clinical Trials as Topic; Drug Evaluation; Dysmenorrhea; Female; Humans | 1978 |
Suppression of menstrual prostaglandins and relief of dysmenorrhea with ibuprofen.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Dysmenorrhea; Female; Follow- | 1979 |
Effect of ibuprofen on menstrual blood prostaglandin levels in dysmenorrheic women.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Menst | 1979 |
Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid.
Topics: Adult; Body Fluids; Double-Blind Method; Dysmenorrhea; Female; Follow-Up Studies; Humans; Ibuprofen; | 1979 |
Dysmenorrhea: treatment with an antiprostaglandin.
Topics: Adolescent; Adult; Dextropropoxyphene; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; | 1979 |
Transcutaneous electrical nerve stimulation (TENS) for the treatment of primary dysmenorrhea: a randomized crossover comparison with placebo TENS and ibuprofen.
Topics: Adult; Combined Modality Therapy; Dysmenorrhea; Female; Humans; Ibuprofen; Randomized Controlled Tri | 1990 |
Ibuprofen and naproxen-sodium in the treatment of primary dysmenorrhea: a double-blind cross-over study.
Topics: Adolescent; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Naproxen; Pain | 1985 |
Ketoprofen, ibuprofen, and placebo in the treatment of primary dysmenorrhea: a double-blind crossover comparison.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Ketop | 1988 |
A double-blind, placebo-controlled study comparing three single-dose regimens of piroxicam with ibuprofen in patients with primary dysmenorrhea.
Topics: Abdomen; Adolescent; Adult; Clinical Trials as Topic; Double-Blind Method; Drug Administration Sched | 1988 |
Ibuprofen is a useful treatment for primary dysmenorrhoea.
Topics: Adolescent; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Middle Aged; Prosta | 1987 |
25 other studies available for ibuprofen and Dysmenorrhea
| Article | Year |
|---|---|
Involvement of a neutrophil-mast cell axis in the effects of Piper malacophyllum (C. PESL) C. DC extract and its isolated compounds in a mouse model of dysmenorrhoea.
Topics: Animals; Disease Models, Animal; Dysmenorrhea; Female; Ibuprofen; Inflammation; Mast Cells; Mice; Ne | 2022 |
Transdermal administration of ibuprofen-loaded hexagonal liquid crystal gel for enhancement of drug concentration in the uterus: in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Dysmenorrhea; Female; Humans; Ibuprofen; Liquid Crystals; Scattering, Sma | 2023 |
Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice.
Topics: Animals; Butylscopolammonium Bromide; Disease Models, Animal; Dysmenorrhea; Edema; Euphorbia; Female | 2019 |
Erythema multiforme minor after ibuprofen use for menstrual pain.
Topics: Adult; Analgesics, Non-Narcotic; Diagnosis, Differential; Dysmenorrhea; Erythema Multiforme; Female; | 2013 |
Potential of Essential Oils as Penetration Enhancers for Transdermal Administration of Ibuprofen to Treat Dysmenorrhoea.
Topics: Administration, Cutaneous; Analgesics, Non-Narcotic; Animals; Cell Line; Cell Survival; Disease Mode | 2015 |
Rett syndrome and menstruation.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Child; Contraceptives, Oral, Hormonal; D | 2012 |
Information from your family doctor. Painful menstrual periods.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral, Hormonal; Dietary Supplements; Dysmen | 2005 |
Naproxen sodium, ibuprofen and a placebo in dysmenorrhea.
Topics: Activities of Daily Living; Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Nap | 1982 |
Menstrual delay and dysfunctional uterine bleeding associated with antiprostaglandin therapy for dysmenorrhea.
Topics: Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Menstruation Disturbances; Prostagla | 1983 |
Dysmenorrhoea: effective new approaches to a controversial problem.
Topics: Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Flufenamic Acid; Humans; Ibuprofen; Indomethacin; M | 1980 |
A double-blind comparison of a propionic acid derivative (ibuprofen) and a fenamate (mefenamic acid) in the treatment of dysmenorrhea.
Topics: Adult; Double-Blind Method; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Pain | 1983 |
From arthritis pain to dysmenorrhea: a new indication for prostaglandin inhibitors.
Topics: Arthritis; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Prostaglandin Antagonists | 1980 |
Dysmenorrhea: a new approach to an old problem.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dysmenorrhea; Female; Humans; Ibuprofen; Mefenamic Acid; Na | 1981 |
Prostaglandin levels in menstrual fluid of nondysmenorrheic and of dysmenorrheic subjects with and without oral contraceptive or ibuprofen therapy.
Topics: Adult; Contraceptives, Oral; Double-Blind Method; Dysmenorrhea; Extracellular Space; Female; Humans; | 1980 |
[Preventive treatment of primary dysmenorrhea with ibuprofen].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dysmenorrhea; Female; Humans; Ibuprofen; Linear Models | 1998 |
Drugs for dysmenorrhea.
Topics: Acetaminophen; Aspirin; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin; Mefenamic Acid; Nalbu | 1979 |
Ibuprofen therapy for primary dysmenorrhea in a university student health service.
Topics: Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Student Health Services | 1979 |
Determination of menstrual prostaglandin levels in non-dysmenorrheic and dysmenorrheic subjects.
Topics: Adult; Contraceptives, Oral; Dysmenorrhea; Female; Humans; Ibuprofen; Menstruation; Pilot Projects; | 1978 |
A clinical trial of indomethacin and ibuprofen in dysmenorrhea.
Topics: Adolescent; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Indomethacin | 1978 |
[Metoxibutropate].
Topics: Adult; Aged; Animals; Dysmenorrhea; Female; Guaiacol; Humans; Ibuprofen; Mice; Pain; Papio; Pregnanc | 1989 |
[Drug therapy of dysmenorrhea].
Topics: Adrenergic beta-Agonists; Adult; Aspirin; Calcium Channel Blockers; Contraceptives, Oral; Dysmenorrh | 1988 |
Pain and its management.
Topics: Adolescent; Analgesics; Dysmenorrhea; Female; Herpes Zoster; Humans; Ibuprofen; Male; Middle Aged; N | 1986 |
A study of naproxen sodium and ibuprofen in primary dysmenorrhoea.
Topics: Adolescent; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Naproxen; Random Allocation | 1987 |
Potent and selective effects of suprofen on uterine prostaglandin synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dysmenorrhea; Female; Guinea Pigs; Ibuprofen; Phenylpr | 1985 |
Intra-uterine pressure and serum ibuprofen: observations after oral administration of 400 mg ibuprofen to a patient with primary dysmenorrhoea.
Topics: Administration, Oral; Adult; Dysmenorrhea; Female; Humans; Ibuprofen; Kinetics; Pain; Pressure; Time | 1985 |