ibuprofen has been researched along with Drug-Related Side Effects and Adverse Reactions in 45 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Drug-Related Side Effects and Adverse Reactions: Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults." | 9.14 | A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. ( Arons, MM; Guntupalli, KK; Morris, PE; Promes, JT; Wright, PE, 2010) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 7.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 7.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| "Hospitalized patients are often unable to ingest or tolerate oral antipyretics and recently an aqueous formulation of intravenous (IV) ibuprofen was approved by the US-FDA for the reduction of fever in adults." | 5.14 | A multi-center, randomized, double-blind, parallel, placebo-controlled trial to evaluate the efficacy, safety, and pharmacokinetics of intravenous ibuprofen for the treatment of fever in critically ill and non-critically ill adults. ( Arons, MM; Guntupalli, KK; Morris, PE; Promes, JT; Wright, PE, 2010) |
| "The aim was to assess whether using LSPS matching would enable the evaluation of paracetamol, compared to ibuprofen, and increased risk of myocardial infarction, stroke, gastrointestinal (GI) bleeding, or acute renal failure." | 3.96 | Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen. ( Berlin, JA; Fife, D; Ryan, PB; Schuemie, MJ; Swerdel, J; Weinstein, RB, 2020) |
| " when patients treated with a drug differ in their underlying risk of adverse outcome from patients given alternate treatments, independent of the effect of the drug)." | 3.78 | When a randomised controlled trial is needed to assess drug safety. The case of paediatric ibuprofen. ( Lesko, SM; Mitchell, AA, 1995) |
| "Two studies were conducted to characterize multiple-dose pharmacokinetics and potential drug interactions of ibuprofen and pseudoephedrine combined in a suspension and to evaluate safety of this combination in children with common cold, flu, or sinusitis." | 3.76 | Multiple-dose pharmacokinetics and safety of an ibuprofen-pseudoephedrine cold suspension in children. ( Gelotte, CK; Lavins, BJ; Pendley, C; Prior, MJ; Zimmerman, B, 2010) |
| "The risk of a newly diagnosed episode of upper gastrointestinal bleeding, acute liver and renal failure, agranulocytosis, aplastic anemia, severe skin disorders, and anaphylaxis was examined within 30 days after the first prescription for a low dose of diclofenac, naproxen, or ibuprofen in a cohort in the United Kingdom." | 3.70 | Low-dose diclofenac, naproxen, and ibuprofen cohort study. ( Duque-Oliart, A; García-Rodríguez, LA; Pérez-Gutthann, S; Varas-Lorenzo, C, 1999) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 3.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| " The risk score was designed to predict the 1-year occurrence of major toxicity among NSAID users, including major adverse cardiovascular events, acute kidney injury, significant gastrointestinal events, and mortality." | 2.90 | Derivation and Validation of a Major Toxicity Risk Score Among Nonsteroidal Antiinflammatory Drug Users Based on Data From a Randomized Controlled Trial. ( Husni, ME; Nissen, S; Paynter, N; Shao, M; Solomon, DH; Wolski, K, 2019) |
| " Two experiments with users of an existing high profile patient information website, investigate the effectiveness of presenting medicine side-effect risk information in different forms." | 2.74 | Perceived risk of medicine side effects in users of a patient information website: a study of the use of verbal descriptors, percentages and natural frequencies. ( Carrigan, N; Gardner, PH; Knapp, P; Raynor, DK; Woolf, E, 2009) |
| "Ibuprofen has less effect on blood flow velocity to important organs." | 2.66 | Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants. ( Ohlsson, A; Shah, SS, 2020) |
| " The review establishes that aspirin, paracetamol and ibuprofen are safe in OTC doses and that there is no evidence for any difference between the medicines as regards efficacy and safety for treatment of colds and flu (except in certain cases such as the use of aspirin in feverish children)." | 2.43 | Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. ( Eccles, R, 2006) |
| "We hypothesized (1) that gastrointestinal (GI) and renal adverse events (AE) would occur more often in infants first prescribed ibuprofen before rather than after six months of age and (2) that ibuprofen would be associated with more adverse effects than acetaminophen in infants younger than six months." | 1.48 | Safety of ibuprofen in infants younger than six months: A retrospective cohort study. ( Bang, H; Rothenberg, SJ; Walsh, P, 2018) |
| "Nonsteroidal anti-inflammatory drugs (NSAIDs), which are globally prescribed, exhibit mainly anti-inflammatory and analgesic effects but also can cause adverse effects including gastrointestinal erosions, ulceration, bleeding, and perforation." | 1.43 | (1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats. ( Choi, KH; Chung, MW; Lee, HJ; Park, JH; Um, SY, 2016) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " Although both classes of drug are generally well tolerated, they can lead to well-characterized adverse effects." | 1.36 | Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes. ( de Vries, F; Setakis, E; van Staa, TP, 2010) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| "Determination of potential drug toxicity and side effect in early stages of drug development is important in reducing the cost and time of drug discovery." | 1.31 | Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach. ( Chen, YZ; Ung, CY, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.22) | 18.7374 |
| 1990's | 3 (6.67) | 18.2507 |
| 2000's | 9 (20.00) | 29.6817 |
| 2010's | 20 (44.44) | 24.3611 |
| 2020's | 12 (26.67) | 2.80 |
| Authors | Studies |
|---|---|
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Kalgutkar, AS | 1 |
| Pelliccia, V | 1 |
| Rossi, S | 1 |
| Zollino, I | 1 |
| Quagliarella, F | 1 |
| Buonocore, G | 1 |
| Dubrall, D | 1 |
| Leitzen, S | 1 |
| Toni, I | 1 |
| Stingl, J | 1 |
| Schulz, M | 1 |
| Schmid, M | 1 |
| Neubert, A | 1 |
| Sachs, B | 1 |
| Pollack, BE | 1 |
| Barbaro, RP | 1 |
| Selewski, DT | 1 |
| Carlton, EF | 1 |
| Marano, M | 1 |
| Roversi, M | 1 |
| Severini, F | 1 |
| Memoli, C | 1 |
| Musolino, A | 1 |
| Pisani, M | 1 |
| Cecchetti, C | 1 |
| Villani, A | 1 |
| Jan-Roblero, J | 1 |
| Cruz-Maya, JA | 1 |
| Lyngstad, G | 1 |
| Skjelbred, P | 1 |
| Swanson, DM | 1 |
| Skoglund, LA | 1 |
| Ohlsson, A | 1 |
| Shah, SS | 1 |
| Chau-Glendinning, H | 1 |
| Baber, B | 1 |
| Neher, JO | 1 |
| Weinstein, RB | 1 |
| Ryan, PB | 1 |
| Berlin, JA | 1 |
| Schuemie, MJ | 1 |
| Swerdel, J | 1 |
| Fife, D | 1 |
| Cooney, MF | 1 |
| Rakowsky, S | 1 |
| Spiller, HA | 1 |
| Casavant, MJ | 1 |
| Chounthirath, T | 1 |
| Hodges, NL | 1 |
| Kim, EH | 1 |
| Smith, GA | 1 |
| Walsh, P | 1 |
| Rothenberg, SJ | 1 |
| Bang, H | 1 |
| Jawaid, H | 1 |
| Hussain, A | 1 |
| Faisal, N | 1 |
| Argiz, L | 1 |
| Múgica, MV | 1 |
| Vega, F | 1 |
| Blanco, C | 1 |
| Solomon, DH | 1 |
| Shao, M | 1 |
| Wolski, K | 1 |
| Nissen, S | 1 |
| Husni, ME | 1 |
| Paynter, N | 1 |
| Li, J | 1 |
| Xu, L | 1 |
| Shi, ZG | 1 |
| Hu, M | 1 |
| Faasse, K | 2 |
| Martin, LR | 1 |
| Grey, A | 2 |
| Gamble, G | 1 |
| Petrie, KJ | 2 |
| Um, SY | 1 |
| Park, JH | 1 |
| Chung, MW | 1 |
| Choi, KH | 1 |
| Lee, HJ | 1 |
| Colgan, SL | 1 |
| Pereira, JA | 1 |
| Knapp, P | 1 |
| Gardner, PH | 1 |
| Carrigan, N | 1 |
| Raynor, DK | 1 |
| Woolf, E | 1 |
| Wolf, MS | 1 |
| Shekelle, P | 1 |
| Choudhry, NK | 1 |
| Agnew-Blais, J | 1 |
| Parker, RM | 1 |
| Shrank, WH | 1 |
| Sethi, NK | 1 |
| Gelotte, CK | 1 |
| Prior, MJ | 1 |
| Pendley, C | 1 |
| Zimmerman, B | 1 |
| Lavins, BJ | 1 |
| Morris, PE | 1 |
| Promes, JT | 1 |
| Guntupalli, KK | 1 |
| Wright, PE | 1 |
| Arons, MM | 1 |
| de Vries, F | 1 |
| Setakis, E | 1 |
| van Staa, TP | 1 |
| Maesschalck, PJ | 1 |
| Schiff, M | 1 |
| Peura, D | 1 |
| Sui, Q | 1 |
| Wang, B | 1 |
| Zhao, W | 1 |
| Huang, J | 1 |
| Yu, G | 1 |
| Deng, S | 1 |
| Qiu, Z | 1 |
| Lu, S | 1 |
| Che, X | 1 |
| Wang, LH | 1 |
| Yang, Y | 1 |
| Yuan, Y | 1 |
| Wang, QF | 1 |
| Wang, Y | 1 |
| Li, SM | 1 |
| Eccles, R | 1 |
| Wen, SW | 1 |
| Yang, T | 1 |
| Krewski, D | 1 |
| Yang, Q | 1 |
| Nimrod, C | 1 |
| Garner, P | 1 |
| Fraser, W | 1 |
| Olatunbosun, O | 1 |
| Walker, MC | 1 |
| Fraunfelder, FT | 1 |
| Pratt, CM | 1 |
| Hertz, RP | 1 |
| Ellis, BE | 1 |
| Crowell, SP | 1 |
| Louv, W | 1 |
| Moyé, L | 1 |
| Mitchell, AA | 1 |
| Lesko, SM | 1 |
| Pérez-Gutthann, S | 1 |
| García-Rodríguez, LA | 1 |
| Duque-Oliart, A | 1 |
| Varas-Lorenzo, C | 1 |
| Chen, YZ | 1 |
| Ung, CY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen[NCT00346216] | Phase 4 | 24,081 participants (Actual) | Interventional | 2006-10-04 | Completed | ||
| Assessment of the Analgesic Efficacy of Intravenous Ibuprofen in Biliary Colic[NCT02268955] | 22 participants (Actual) | Interventional | 2014-09-09 | Completed | |||
| A Prospective, Randomized, Double-blind Study Assessing the Efficacy of Intravenous (IV) Ibuprofen Versus IV Acetaminophen for the Treatment of Pain Following Orthopaedic Low Extremity Surgery[NCT03771755] | 62 participants (Actual) | Interventional | 2017-07-01 | Completed | |||
| A Multicenter, Randomized, Double-blind, Parallel, Placebo-controlled Trial To Evaluate The Efficacy, Safety, and Pharmacokinetics of Ibuprofen Injection in Adult Febrile Patients[NCT01131000] | Phase 3 | 123 participants (Actual) | Interventional | 2002-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"VAS question How much pain do you have was graded on a scale from 0 to 100 with 0 indicating No pain and 100 indicating Worst possible pain." (NCT00346216)
Timeframe: ITT and MITT Population - Baseline to 42 months
| Intervention | Number of participants (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (ITT) N= 8014, 8001, 7928 | Change-Baseline to Mon1 (ITT) N=7382, 7379, 7325 | Change-Baseline to Mon2 (ITT) N=7180, 7090, 7149 | Change-Baseline to Mon4 (ITT) N=6777, 6696, 6740 | Change-Baseline to Mon8 (ITT) N=6230, 6137, 6159 | Change-Baseline to Mon12 (ITT) N=5792, 5696, 5846 | Change-Baseline to Mon18 (ITT) N=5310, 5181. 5246 | Change-Baseline to Mon24 (ITT) N=4818, 4776, 4785 | Change-Baseline to Mon30 (ITT) N=4140, 4069, 4086 | Change-Baseline to Mon36 (ITT) N=3692, 3627, 3635 | Change-Baseline to Mon42 (ITT) N=3469, 3406, 3439 | Baseline (MITT) N=7974, 7954, 7894 | Change-Baseline to Mon1 MITT N=7372, 7367, 7321 | Change-Baseline to Mon2 MITT N=7170, 7078, 7142 | Change-Baseline to Mon4 MITT N=6772, 6686, 6732 | Change-Baseline to Mon8 MITT N=6224, 6128, 6155 | Change-Baseline to Mon12 MITT N=5787, 5689, 5844 | Change-Baseline to Mon18 MITT N=5305, 5175, 5242 | Change-Baseline to Mon24 MITT N=4815, 4769, 4782 | Change-Baseline to Mon30 MITT N=4139, 4067, 4085 | Change-Baseline to Mon36 MITT N=3691, 3623, 3635 | Change-Baseline to Mon42 MITT N=3468, 3404, 3438 | |
| Celecoxib | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.3 | -10.5 | -10.1 | -11.4 | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.4 | -10.5 | -10.2 | -11.4 |
| Ibuprofen | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 |
| Naproxen | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.4 | -11.3 | -11.6 | -12.1 | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.3 | -11.3 | -11.6 | -12.1 |
MACE defined as the composite of CV death (including hemorrhagic death), non-fatal MI, non-fatal stroke, hospitalization for UA, revascularization or hospitalization for TIA (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 4.2 | 3.1 |
| Ibuprofen | 4.8 | 3.6 |
| Naproxen | 4.3 | 3.2 |
APTC events are defined as a composite of any of the following events: Death due to CV causes (including cardiac, cerebrovascular, venous thromboembolic, haemorrhagic, other vascular, or unknown cause); Non-fatal MI; Non-fatal stroke (including intracranial hemorrhages, stroke of ischemic or unknown etiology). (NCT00346216)
Timeframe: Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months
| Intervention | Percentage of Partcipants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 2.3 | 1.7 |
| Ibuprofen | 2.7 | 1.9 |
| Naproxen | 2.5 | 1.8 |
CSGIE include: Gastroduodenal (GD) hemorrhage, Gastric outlet obstruction, Gastroduodenal, small bowel or large bowel perforation, Large bowel hemorrhage, Small bowel hemorrhage, Acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage, Symptomatic gastric or duodenal ulcer (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 0.7 | 0.3 |
| Ibuprofen | 0.9 | 0.7 |
| Naproxen | 0.7 | 0.7 |
Pain is measured on a visual analog scale 0=no pain and 10=worst pain imaginable. (NCT02268955)
Timeframe: 120 minutes post medication administration
| Intervention | score on a scale (Median) |
|---|---|
| Control Group: Adults Age 18-55 Years | 3.0 |
| IV Ibuprofen: Adults Age 18-55 Years | 0.3 |
8 reviews available for ibuprofen and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Ibuprofen: Toxicology and Biodegradation of an Emerging Contaminant.
Topics: Bacteria; Biodegradation, Environmental; Drug-Related Side Effects and Adverse Reactions; Humans; Ib | 2023 |
Ibuprofen for the prevention of patent ductus arteriosus in preterm and/or low birth weight infants.
Topics: Cerebral Hemorrhage; Cyclooxygenase Inhibitors; Drug-Related Side Effects and Adverse Reactions; Duc | 2020 |
Do prophylactic antipyretics reduce vaccination-associated symptoms in children?
Topics: Acetaminophen; Antipyretics; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reaction | 2020 |
Pain Management in Children: NSAID Use in the Perioperative and Emergency Department Settings.
Topics: Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug-Related Side Effects and Ad | 2021 |
[Efficacy and safety of ibuprofen and paracetamol in fever among children].
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Combin | 2011 |
HZT-501 (DUEXIS(®); ibuprofen 800 mg/famotidine 26.6 mg) gastrointestinal protection in the treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Drug Combinations | 2012 |
Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu.
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child; Child, Preschool; Com | 2006 |
When a randomised controlled trial is needed to assess drug safety. The case of paediatric ibuprofen.
Topics: Drug-Related Side Effects and Adverse Reactions; Humans; Ibuprofen; Pediatrics; Randomized Controlle | 1995 |
6 trials available for ibuprofen and Drug-Related Side Effects and Adverse Reactions
32 other studies available for ibuprofen and Drug-Related Side Effects and Adverse Reactions
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Designing around Structural Alerts in Drug Discovery.
Topics: Drug Design; Drug Development; Drug Discovery; Drug-Related Side Effects and Adverse Reactions; Huma | 2020 |
Adverse Drug Reactions of Acetaminophen and Ibuprofen in the Paediatric Population: Analysis of the Italian Spontaneous Reporting Database.
Topics: Acetaminophen; Adolescent; Adverse Drug Reaction Reporting Systems; Child; Child, Preschool; Drug-Re | 2022 |
Descriptive analysis of adverse drug reaction reports in children and adolescents from Germany: frequently reported reactions and suspected drugs.
Topics: Adolescent; Atomoxetine Hydrochloride; Child; Child, Preschool; Drug Combinations; Drug-Related Side | 2021 |
Safety warning: combination products containing codeine and ibuprofen.
Topics: Adverse Drug Reaction Reporting Systems; Codeine; Drug-Related Side Effects and Adverse Reactions; E | 2023 |
Lactic acidosis and multisystem organ failure following ibuprofen overdose requiring haemodialysis.
Topics: Acidosis, Lactic; Drug Overdose; Drug-Related Side Effects and Adverse Reactions; Humans; Hypoglycem | 2023 |
Adverse drugs reactions to paracetamol and ibuprofen in children: a 5-year report from a pediatric poison control center in Italy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Child; Child, Preschool; Drug-Related Side Effects and Adve | 2023 |
Channeling Bias in the Analysis of Risk of Myocardial Infarction, Stroke, Gastrointestinal Bleeding, and Acute Renal Failure with the Use of Paracetamol Compared with Ibuprofen.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Ag | 2020 |
Antipyretic Medication Exposures Among Young Children Reported to US Poison Centers, 2000-2015.
Topics: Acetaminophen; Age Distribution; Antipyretics; Child; Child, Preschool; Confidence Intervals; Databa | 2018 |
Safety of ibuprofen in infants younger than six months: A retrospective cohort study.
Topics: Acetaminophen; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Ibuprofen; Incidence | 2018 |
Ibuprofen and its associated alterations in testicular physiology - Letter to the Editor.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug-Related Side Effects and Adverse Reactions; Humans; Ib | 2018 |
Drug-Induced Fixed Urticaria as a Presentation of NSAID Intolerance.
Topics: Administration, Oral; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Drug Hypersensiti | 2019 |
A novel two-dimensional liquid chromatographic system for the online toxicity prediction of pharmaceuticals and related substances.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Chlorophyta; Chromatography, Liquid; C | 2015 |
(1)H-Nuclear magnetic resonance-based metabolic profiling of nonsteroidal anti-inflammatory drug-induced adverse effects in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Celecoxib; Cyclooxygenase 2 Inhibitors; D | 2016 |
Changing perceptions and efficacy of generic medicines: An intervention study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Substitution; Drug-Related Side Eff | 2016 |
Variability in pharmacy interpretations of physician prescriptions.
Topics: Alendronate; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Atorvastatin; Bone Dens | 2009 |
Excessive acute migraine medication use and migraine progression.
Topics: Acute Disease; Analgesics; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Barbiturates | 2009 |
Multiple-dose pharmacokinetics and safety of an ibuprofen-pseudoephedrine cold suspension in children.
Topics: Administration, Oral; Age Factors; Area Under Curve; Case-Control Studies; Child; Child, Preschool; | 2010 |
Concomitant use of ibuprofen and paracetamol and the risk of major clinical safety outcomes.
Topics: Acetaminophen; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; | 2010 |
Identification of priority pharmaceuticals in the water environment of China.
Topics: Anti-Bacterial Agents; Cephalexin; China; Diclofenac; Drug Utilization; Drug-Related Side Effects an | 2012 |
Ibuprofen ion-exchange fiber complex: improved dissolution and gastric tolerance based on ion exchange.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Drug Carriers; Drug-Rel | 2013 |
Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population.
Topics: Adult; Albuterol; Contraceptives, Oral; Cross-Sectional Studies; Drug Prescriptions; Drug-Related Si | 2008 |
Exercise caution when taking ibuprofen. High doses of ibuprofen have been associated with an increased risk of cardiovascular events. How much is safe?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular Diseases; Drug-Related Side Effects and Adve | 2007 |
Interim report: National Registry of possible Drug-induced Ocular Side Effects.
Topics: Contact Lenses; Drug-Related Side Effects and Adverse Reactions; Eye Diseases; Fluorouracil; Humans; | 1980 |
Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Clemastine; Cohort Studies; Death, Sudden, Cardiac; | 1994 |
Low-dose diclofenac, naproxen, and ibuprofen cohort study.
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Aged, 80 and over; Anaphylaxis; Anti-Inflammatory Agen | 1999 |
Prediction of potential toxicity and side effect protein targets of a small molecule by a ligand-protein inverse docking approach.
Topics: Ascorbic Acid; Aspirin; Computer Simulation; Drug-Related Side Effects and Adverse Reactions; Gentam | 2001 |