ibuprofen and Disease Models, Animal studies

Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.

Research Excerpts

Excerpt	Relevance	Reference
" Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine."	7.88	Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018)
" Both ibuprofen and L-arginine exert antiallodynic effects on chronic constriction injury (CCI)-induced cold allodynia."	7.83	Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy. ( Abd-Alkhalek, HA; El-Bakly, WM; El-Lithy, GM; Hamza, M; Masoud, SI; Matboli, M, 2016)
"The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate."	7.77	Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice. ( Chen, CC; Tang, HJ; Toh, HS; Weng, TC, 2011)
"Aspirin (acetylsalicylic acid) or ibuprofen [2-(4-isobutyl-phenyl)-propionic acid] was administered to mice undergoing treatment of tuberculosis infection with pyrazinamide to determine if these non-steroidal anti-inflammatory drugs (NSAIDs) enhance pyrazinamide activity in vivo."	7.74	Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis. ( Byrne, ST; Denkin, SM; Zhang, Y, 2007)
"The impact of ibuprofen combined with amoxicillin or erythromycin for therapy of penicillin-resistant pneumococcal acute otitis media (AOM) was evaluated in a gerbil model."	7.73	Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin. ( Cenjor, C; del Prado, G; Fernández-Roblas, R; Gracia, M; Huelves, L; Martínez-Marín, C; Ponte, C; Rodríguez-Cerrato, V; Soriano, F, 2006)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."	7.72	Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."	7.71	Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
"Ibuprofen administration during endotoxin shock seems to decrease the elevated ET concentrations, and increase the blood pressure."	7.71	Effects of ibuprofen on plasma endothelin levels and some vital parameters during endotoxin shock in rabbits. ( Akbulut, A; Canbaz, M; Celik, I; Vural, P, 2002)
"The efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion and resolution of mucosal inflammation."	7.69	Treatment of experimental acute otitis media with ibuprofen and ampicillin. ( Alper, C; Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Jaffe, R, 1995)
"We have used the rat air pouch model of inflammation and S(+)ibuprofen as an experimental model system to enable the quantitative assessment of the pharmacokinetic determinants of site specific drug delivery."	7.69	Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation. ( Brennan, BS; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1994)
" Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model."	5.62	Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021)
"Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days."	5.51	Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019)
"The hepatic encephalopathy was induced by bile-duct ligation (BDL), and the animals received first dose of MINO and/or IBU 15 days later and then every day until the 28 day."	5.51	Inhibition of inflammation is not enough for recovery of cognitive impairment in hepatic encephalopathy: Effects of minocycline and ibuprofen. ( Firouzjaei, MA; Haghani, M; Mohammadi, F; Mohammadian, F; Shabani, M; Shid Moosavi, SM, 2019)
"Machado-Joseph disease or spinocerebellar ataxia type 3 is an inherited neurodegenerative disease associated with an abnormal glutamine over-repetition within the ataxin-3 protein."	5.51	Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models. ( Brinkhaus, M; Henriques, D; Kaspar, BK; Matos, C; Mendonça, LS; Moreira, R; Nóbrega, C; Pereira de Almeida, L; Tavino, S; Tomé, S, 2019)
"Ibuprofen treatment of polarized CFBE41o(-) monolayers increased the short-circuit current (Isc) response to stimulation."	5.42	Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. ( Carlile, GW; Goepp, J; Hanrahan, JW; Kus, B; Liao, J; Macknight, SD; Matthes, E; Robert, R; Rotin, D; Thomas, DY, 2015)
"Ibuprofen was incorporated into ethylene-vinyl acetate (EVAc) polymers at 45% loading (wt:wt)."	5.33	Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. ( Clatterbuck, RE; Gailloud, P; Legnani, FG; Murphy, KP; Pradilla, G; Tamargo, RJ; Thai, QA, 2005)
"Ibuprofen is an antiinflammatory agent that inhibits the expression of specific cell adhesion molecules and, consequently, disrupts leukocyte-endothelial cell interactions."	5.32	Inhibition of cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit model of subarachnoid hemorrhage. ( Frazier, JL; Pradilla, G; Tamargo, RJ; Wang, PP, 2004)
"Main parameter was thrombus weight."	5.32	Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004)
"The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits."	5.31	Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000)
" To assess the usefulness of this model for testing potential analgesics, three known synthetic pain medications were assessed (ibuprofen, acetaminophen and tramadol) along with three naturally occurring products (honokiol, tetrahydrocannabinol and cannabidiol)."	3.88	Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception. ( Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M, 2018)
" Hence, thalidomide (100, 200 and 400 mg/kg) was herein administered to mice to evaluate possible protection against seizures induced by the systemic administration of neurotoxins: 10 mg/kg of 4-aminopyridine (4-AP), 90 mg/kg of pentylenetetrazol (PTZ), or 380 mg/kg of pilocarpine."	3.88	Thalidomide protects against acute pentylenetetrazol and pilocarpine-induced seizures in mice. ( Campos-Rodriguez, C; Islas-Espinoza, AM; San Juan, ER, 2018)
"The present study is to investigate the neuroprotective effect of ibuprofen by intranasal administration of mucoadhesive microemulsion (MMEI) against inflammation-mediated by dopaminergic neurodegeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease (PD)."	3.83	Design and evaluation of mucoadhesive microemulsion for neuroprotective effect of ibuprofen following intranasal route in the MPTP mice model. ( Chuttani, K; Mandal, S; Mandal, SD; Sawant, KK; Subudhi, BB, 2016)
" Both ibuprofen and L-arginine exert antiallodynic effects on chronic constriction injury (CCI)-induced cold allodynia."	3.83	Prophylactic L-arginine and ibuprofen delay the development of tactile allodynia and suppress spinal miR-155 in a rat model of diabetic neuropathy. ( Abd-Alkhalek, HA; El-Bakly, WM; El-Lithy, GM; Hamza, M; Masoud, SI; Matboli, M, 2016)
"In the therapy of rheumatoid arthritis, ibuprofen (IBU) is widely used; however, it has been limited the clinical use by its systemic side effect, such as gastrointestinal lesions."	3.83	Pharmacokinetic Studies of Gel System Containing Ibuprofen Solid Nanoparticles. ( Ito, Y; Nagai, N; Tanino, T, 2016)
" In particular, 14 and 15 were found to be more potent than morphine for both acute and inflammatory pain models and 100-fold more potent than gabapentin in a diabetic neuropathic pain model."	3.81	Antinociceptive Grayanoids from the Roots of Rhododendron molle. ( Li, Y; Liu, Y; Liu, YB; Lv, HN; Ma, SG; Qu, J; Yu, SS; Zhang, JJ, 2015)
" To investigate whether innate rodent burrowing is a useful alternative behavioural readout for assessment of analgesic efficacy, a complete Freund's adjuvant (CFA)-induced model of sub-chronic inflammation was used to compare the effects of naproxen, ibuprofen and pregabalin in weight-bearing (WB), open-field (OF) and burrowing assays."	3.80	Burrowing as a non-reflex behavioural readout for analgesic action in a rat model of sub-chronic knee joint inflammation. ( Christoph, T; Leipelt, A; Pasqualon, T; Read, SJ; Robens, A; Rutten, K; Schiene, K, 2014)
" These results suggest that ceftriaxone, particularly in combinations with ibuprofen, celecoxib, paracetamol, or levetiracetam, may provide useful approach to the clinical treatment of inflammation-related pain."	3.80	Antihyperalgesic/antinociceptive effects of ceftriaxone and its synergistic interactions with different analgesics in inflammatory pain in rodents. ( Boškovic, BD; Kovacevic, JM; Micov, AM; Stepanovic-Petrovic, RM; Tomic, MA, 2014)
"9 mg/kg, CARR) hypersensitivity, whereas ibuprofen (CARR, mechanical allodynia) and celecoxib (CARR, thermal hyperalgesia; CFA, mechanical allodynia) failed to reach maximum efficacy."	3.80	S1RA, a selective sigma-1 receptor antagonist, inhibits inflammatory pain in the carrageenan and complete Freund's adjuvant models in mice. ( Gris, G; Merlos, M; Portillo-Salido, E; Vela, JM; Zamanillo, D, 2014)
"The effects of long-term use of celecoxib, ibuprofen, and indomethacin on types I, II, and III collagen metabolism were evaluated in rat osteoarthritis (OA) model."	3.78	The effects of NSAIDs on types I, II, and III collagen metabolism in a rat osteoarthritis model. ( An, H; Jiang, DM; Luo, XJ; Ou, YS; Quan, ZX; Tan, C; Tang, K, 2012)
" As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA."	3.78	Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. ( Del Rio, R; Iturriaga, R; Madrid, C; Moya, EA; Parga, MJ, 2012)
"The results supported the concept that ibuprofen use in GAS soft tissue infections might induce the development of severe necrotizing infections and increase mortality rate."	3.77	Ibuprofen worsens Streptococcus pyogenes soft tissue infections in mice. ( Chen, CC; Tang, HJ; Toh, HS; Weng, TC, 2011)
"Recently we reported that intrathalamic microinjection of carbachol triggers generalized convulsive seizures (GCS) followed by severe inflammatory response including edema, microhemorrhages, and subsequent degeneration of amygdaloallocortical area."	3.76	Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways. ( Mraovitch, S; Régnier, A; Vicaut, E, 2010)
" IBU blocked LPS-induced fever but did not block LPS-induced increases in plasma cytokines and corticosterone in the pregnant dam."	3.75	Effects of prenatal immune activation on hippocampal neurogenesis in the rat. ( Ashdown, H; Boksa, P; Cui, K; Luheshi, GN, 2009)
"A series of new tetrasubstituted thiophenes (4a-4i, 5a-5i and 6a-6f) have been synthesized as novel anti-inflammatory agents and were evaluated for their anti-inflammatory activity in carrageenin-induced rat hind paw oedema model at the doses of 10, 20 and 40mg/kg body weight."	3.74	Syntheses of new tetrasubstituted thiophenes as novel anti-inflammatory agents. ( Haque, N; Molvi, KI; Sudarsanam, V; Vasu, KK; Yerande, SG, 2007)
"Atherosclerosis being considered as an inflammatory disorder, the present study was undertaken to investigate the effectiveness of anti-inflammatory drugs (ibuprofen, aspirin, and celecoxib) in hypercholesterolemia."	3.74	Antiatherosclerotic activity of ibuprofen, a non-selective COX inhibitor--an animal study. ( Dabhi, JK; Mehta, A; Solanki, JK, 2008)
"Aspirin (acetylsalicylic acid) or ibuprofen [2-(4-isobutyl-phenyl)-propionic acid] was administered to mice undergoing treatment of tuberculosis infection with pyrazinamide to determine if these non-steroidal anti-inflammatory drugs (NSAIDs) enhance pyrazinamide activity in vivo."	3.74	Aspirin and ibuprofen enhance pyrazinamide treatment of murine tuberculosis. ( Byrne, ST; Denkin, SM; Zhang, Y, 2007)
" In a chronic model, by acetic acid-induced gastric ulcers, COX-2 was expressed at 7 days and was also associated with PGE(2) increase."	3.73	COX expression and PGE(2) and PGD(2) production in experimental acute and chronic gastric lesions. ( Alarcón de la Lastra, C; Bruseghini, L; Manuel Herrerias, J; Motilva, V; Sánchez-Fidalgo, S, 2005)
"The impact of ibuprofen combined with amoxicillin or erythromycin for therapy of penicillin-resistant pneumococcal acute otitis media (AOM) was evaluated in a gerbil model."	3.73	Impact of ibuprofen therapy in the outcome of experimental pneumococcal acute otitis media treated with amoxicillin or erythromycin. ( Cenjor, C; del Prado, G; Fernández-Roblas, R; Gracia, M; Huelves, L; Martínez-Marín, C; Ponte, C; Rodríguez-Cerrato, V; Soriano, F, 2006)
"Animals that received ibuprofen during hyperoxia exposure had a significantly lower median (25th, 75th quartile) retinopathy score of 6 (5, 7."	3.72	Ibuprofen improves oxygen-induced retinopathy in a mouse model. ( Barr, SM; Geng, Y; Higgins, RD; Sharma, J; Yun, Y, 2003)
" We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice."	3.72	Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004)
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."	3.71	Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
"Ibuprofen administration during endotoxin shock seems to decrease the elevated ET concentrations, and increase the blood pressure."	3.71	Effects of ibuprofen on plasma endothelin levels and some vital parameters during endotoxin shock in rabbits. ( Akbulut, A; Canbaz, M; Celik, I; Vural, P, 2002)
"A series of 2-substituted- and 2,3-disubstituted-4-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-1H- pyrroles was synthesized and found to be active in the rat adjuvant arthritis model of inflammation."	3.69	Antiinflammatory 4,5-diarylpyrroles: synthesis and QSAR. ( Galbraith, W; Gans-Brangs, K; Grubb, M; Hewes, WE; Jaffee, B; Kenney, JP; Kerr, J; Wilkerson, WW; Wong, N, 1994)
"The efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion and resolution of mucosal inflammation."	3.69	Treatment of experimental acute otitis media with ibuprofen and ampicillin. ( Alper, C; Burckart, GJ; Diven, WF; Doyle, WJ; Evans, RW; Jaffe, R, 1995)
"We have used the rat air pouch model of inflammation and S(+)ibuprofen as an experimental model system to enable the quantitative assessment of the pharmacokinetic determinants of site specific drug delivery."	3.69	Experimental determination of a drug targeting index for S(+)ibuprofen using the rat air pouch model of inflammation. ( Brennan, BS; Houston, JB; Martin, SW; Rowland, M; Stevens, AJ, 1994)
" We have tested the efficacy of topically given S(+)-ibuprofen in a rabbit model of uveitis secondary to the intravitreal injection of human recombinant interleukin 1-alpha."	3.68	The effects of topical S(+)-ibuprofen on interleukin-1 induced ocular inflammation in a rabbit model. ( Boney, RS; Goldenberg, MM; Rosenbaum, JT; Tilden, ME, 1990)
"The present study evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 minutes of warm ischemia."	3.67	Pharmacologic modulation of experimental postischemic hepatic function. ( Makowka, L; Mazzaferro, V; Ontell, SJ; Ove, P; Starzl, TE; Trager, J, 1989)
"In anesthetized dogs ethchlorvynol (ECV, 9 mg/kg) was selectively administered into the right pulmonary circulation to produce unilateral acute lung injury (ALI) characterized by nonhydrostatic pulmonary edema and systemic hypoxemia."	3.67	Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. ( Dahms, TE; Lonigro, AJ; Sprague, RS; Stephenson, AH, 1986)
"The effects of ibuprofen (I) and methylprednisolone (M) were studied in the Pseudomonas porcine model of adult respiratory distress syndrome (ARDS)."	3.67	Ibuprofen and methylprednisolone in a pig Pseudomonas ARDS model. ( Blocher, CR; Harvey, CF; Lee, EC; Sielaff, TD; Sugerman, HJ; Tatum, JL, 1987)
"The automated system for measuring canine paw pressure is a very useful tool for the evaluation of nonsteroid antiinflammatory drugs such as indomethacin and ibuprofen in the dog synovitis model."	3.67	An automated microcomputer-based system for determining canine paw pressure quantitatively in the dog synovitis model. ( Brunner, TR; Carlson, RP; Datko, LJ; Purvis, WF; Shaw, GW; Thompson, JL; Welch, TM, 1986)
" The effects of ibuprofen, methylprednisolone-sodium succinate, and gentamicin alone, or in combination on survival time and, TxA2 and PGI2 production in rats in a LD100 fecal peritonitis shock model were assessed."	3.67	Ibuprofen, methylprednisolone, and gentamicin as conjoint therapy in septic shock. ( Cook, JA; Halushka, PV; Knapp, RG; Wise, WC, 1985)
" We investigated, in an animal model, whether a non-steroidal anti-inflammatory drug, ibuprofen, reduced lung inflammation produced by P."	3.67	Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa. ( Bellanti, JA; Cerquetti, MC; el-Tawil, G; Hooke, AM; Ramwell, PW; Sordelli, DO, 1985)
"Ibuprofen is a prototypical non-steroidal anti-inflammatory drug that decreases PGE2 levels by inhibiting cyclooxygenase."	2.82	A Randomized Placebo Controlled Trial of Ibuprofen for Respiratory Syncytial Virus Infection in a Bovine Model. ( Agrawal, K; Anderson, M; Behrens, N; Carvallo Chaigneau, FR; Gershwin, LJ; McEligot, H; Newman, JW; Walsh, P, 2016)
" Epidemiological studies have shown that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk of developing AD and delays its onset."	2.43	Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. ( Praticò, D; Townsend, KP, 2005)
" ECa 233 may be alternatively and safely used for treating chronic inflammatory TMD pain, showing an inverted U-shaped dose-response relationship with maximal effect at 100 mg/kg."	1.91	Standardized Centella asiatica (ECa 233) extract decreased pain hypersensitivity development in a male mouse model of chronic inflammatory temporomandibular disorder. ( Care, C; Chindasri, W; Pakaprot, N; Rotpenpian, N; Tantisira, MH; Tapechum, S; Tilokskulchai, K; Vattarakorn, A; Wanasuntronwong, A, 2023)
"The in-vivo pharmacodynamic (PD) studies were performed in mice."	1.72	Pharmacodynamic/pharmacokinetic correlation of optimized ibuprofen nanosuspensions having enhanced anti-inflammatory and antinociceptive activity. ( Bandarkar, F; Masocha, W; Nada, A, 2022)
"The "cimetidine + ibuprofen"-treated mice displayed greater T-bet expression than the un-treated mice (P<0."	1.72	Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. ( Hassan, ZM; Jafarzadeh, A; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2022)
" Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model."	1.62	Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021)
"Mechanical allodynia, heat hyperalgesia, biased weight-bearing, and hindpaw thickness were assessed 0."	1.62	Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats. ( Britch, SC; Craft, RM; Hewitt, KA, 2021)
"Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days."	1.51	Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019)
"Ibuprofen is a worldwide used non-steroidal anti-inflammatory drug which may cause acute liver injury (ALI) requiring liver transplantation."	1.51	Protective role of c-Jun N-terminal kinase-2 (JNK2) in ibuprofen-induced acute liver injury. ( Andrade, RJ; Bast, A; Bechmann, LP; Cubero, FJ; Koek, GH; Lucena, MI; Nelson, LJ; Sydor, S; Trautwein, C; Woitok, MM; Zoubek, ME, 2019)
"The hepatic encephalopathy was induced by bile-duct ligation (BDL), and the animals received first dose of MINO and/or IBU 15 days later and then every day until the 28 day."	1.51	Inhibition of inflammation is not enough for recovery of cognitive impairment in hepatic encephalopathy: Effects of minocycline and ibuprofen. ( Firouzjaei, MA; Haghani, M; Mohammadi, F; Mohammadian, F; Shabani, M; Shid Moosavi, SM, 2019)
"Machado-Joseph disease or spinocerebellar ataxia type 3 is an inherited neurodegenerative disease associated with an abnormal glutamine over-repetition within the ataxin-3 protein."	1.51	Ibuprofen enhances synaptic function and neural progenitors proliferation markers and improves neuropathology and motor coordination in Machado-Joseph disease models. ( Brinkhaus, M; Henriques, D; Kaspar, BK; Matos, C; Mendonça, LS; Moreira, R; Nóbrega, C; Pereira de Almeida, L; Tavino, S; Tomé, S, 2019)
" The prostate tissue penetration and related pharmacokinetic parameters were evaluated by non-compartmental analysis."	1.48	Penetration and pharmacokinetics of non-steroidal anti-inflammatory drugs in rat prostate tissue. ( Radhakrishnan, J; Radhakrishnan, R; Yellepeddi, VK, 2018)
"Cromolyn sodium is an asthma therapeutic agent previously shown to reduce Aβ levels in transgenic AD mouse brains after one-week of treatment."	1.48	Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. ( Elmaleh, DR; Forte, AM; Griciuc, A; Hudry, E; Quinti, L; Ran, C; Shen, X; Tanzi, RE; Wan, Y; Ward, J; Zhang, C, 2018)
"Ibuprofen was given to the treatment group (TG) and water was given to the control group (CG)."	1.46	Investigating Cyclooxygenase Inhibition in a Rat Pulmonary Contusion Model: A Laboratory Study Finding No Improvement with Ibuprofen. ( Chatterjee, AR; Croce, MA; Fabian, TC; Huang, J; Khan, NR; Magnotti, LJ; Sharpe, JP, 2017)
"We tested whether this parameter and tactile allodynia, the standard pain measure in preclinical studies, show parallels in their response to analgesics and basic mechanisms."	1.46	Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia. ( Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ, 2017)
"Studies have shown altered pharmacokinetic patterns (PK) in patient suffering from acute pain."	1.43	Disease specific modeling: Simulation of the pharmacokinetics of meloxicam and ibuprofen in disease state vs. healthy conditions. ( Aghazadeh-Habashi, A; Almukainzi, M; Jamali, F; Löbenberg, R, 2016)
"Identifying preventive targets for Alzheimer's disease is a central challenge of modern medicine."	1.43	Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice. ( Andreasson, KI; Boutaud, O; Brown, H; Chuluun, B; Colas, D; Heller, HC; Khroyan, TV; Ko, N; Liang, X; Manning-Boğ, AB; Mhatre, SD; Milne, GL; Minhas, P; Panchal, M; Priyam, PG; Rassoulpour, A; van der Hart, M; Wang, Q; Woodling, NS; Zagol-Ikapitte, I, 2016)
"Ibuprofen treatment of polarized CFBE41o(-) monolayers increased the short-circuit current (Isc) response to stimulation."	1.42	Ibuprofen rescues mutant cystic fibrosis transmembrane conductance regulator trafficking. ( Carlile, GW; Goepp, J; Hanrahan, JW; Kus, B; Liao, J; Macknight, SD; Matthes, E; Robert, R; Rotin, D; Thomas, DY, 2015)
"Diclofenac treatment produced dose-related reversal of CRANE at 0."	1.42	Complete Freund's adjuvant-induced reduction of exploratory activity in a novel environment as an objective nociceptive endpoint for sub-acute inflammatory pain model in rats. ( Bannon, AW; Joshi, SK; Zhu, CZ, 2015)
"Ibuprofen was added to the samples at doses of 0 μg/mL (control), recommended oral dose (163 μg/mL, 1×), 2×, 4×, 8×, 10×, 12×, 16×, and 20×."	1.42	Effect of Ibuprofen dose on platelet aggregation and coagulation in blood samples from pigs. ( Deguzman, R; Dubick, MA; Guerra, J; Martini, AK; Martini, WZ; Pusateri, AE; Rodriguez, CM, 2015)
"Eighteen (90%) wounds in the saline-chitosan group and 11 (55%) wounds in the saline-gauze group were healed."	1.42	Locally Delivered Nonsteroidal Antiinflammatory Drug: A Potential Option for Heterotopic Ossification Prevention. ( Hsu, JR; Noel, SP; Rathbone, CR; Rivera, JC; Wenke, JC, 2015)
"Ibuprofen treatment preserved trabecular bone quality by reducing osteoclasts and bone inflammatory cytokines, and improving muscle pulling forces on bones as a result of reduced nerve inflammation."	1.40	Bone loss from high repetitive high force loading is prevented by ibuprofen treatment. ( Barbe, MF; Barr-Gillespie, AE; Clark, BD; Jain, NX; Kietrys, DM; Litvin, J; Popoff, SN; Wade, CK, 2014)
"Ibuprofen is a widely used nonsteroidal anti-inflammatory drug that reportedly reduces the risk of Alzheimer's disease (AD) development."	1.40	Ibuprofen partially attenuates neurodegenerative symptoms in presenilin conditional double-knockout mice. ( Dong, Z; Huang, G; Mei, B; Meng, B; Yan, L; Zhang, L, 2014)
"Cystitis was induced in female rats by a single CYP injection."	1.39	Relevance of the cyclophosphamide-induced cystitis model for pharmacological studies targeting inflammation and pain of the bladder. ( Augé, C; Chene, G; Coelho, AM; Corman, B; Desoubzdanne, D; Dubourdeau, M; Lluel, P; Palea, S; Vergnolle, N, 2013)
"Ibuprofen was shown to protect neurons against MPTP-induced injury in the striatum."	1.39	Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease. ( Członkowski, A; Joniec, I; Kurkowska-Jastrzębska, I; Swiątkiewicz, M; Zaremba, M, 2013)
"Hypertension and sporadic Alzheimer's disease (AD) have been associated but clear pathophysiological links have not yet been demonstrated."	1.38	Role of neuroinflammation in hypertension-induced brain amyloid pathology. ( Ajmone-Cat, MA; Alleva, E; Branchi, I; Carnevale, D; Carnevale, L; Carullo, P; Cifelli, G; Cocozza, G; D'Andrea, I; Frati, A; Lembo, G; Madonna, M; Mascio, G; Minghetti, L, 2012)
"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has been reported to reduce the risk of developing Alzheimer's disease (AD)."	1.38	No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. ( Bayer, TA; Bulic, B; Demuth, HU; Hahn, S; Hillmann, A; Hoffmann, T; Schilling, S; Schneider-Axmann, T; Weggen, S; Wirths, O, 2012)
"Ibuprofen arginate is a highly soluble salt formed by combining racemic ibuprofen with the amino acid l-arginine."	1.38	Comparison of the antinociceptive effects of ibuprofen arginate and ibuprofen in rat models of inflammatory and neuropathic pain. ( Berrocoso, E; Leza, JC; Mico, JA; Ortega-Álvaro, A; Rey-Brea, R, 2012)
"Ibuprofen was found to down-regulate the TBI-induced inflammatory response."	1.38	Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury. ( Forsberg-Nilsson, K; Hånell, A; Hillered, L; Holmqvist, K; Marklund, N; Wallenquist, U, 2012)
" We examined the possibility that concurrent blockade of free radicals and prostaglandin E(2) (PGE(2))-mediated inflammation might constitute a safe and effective therapeutic approach to ALS."	1.38	Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ( Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS, 2012)
"The neuronopathic forms of Gaucher's disease are characterized by severe neuronal loss, astrocytosis and microglial proliferation, but the cellular and molecular pathways causing these changes are not known."	1.38	Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease. ( Biton, I; Eilam, R; Farfel-Becker, T; Futerman, AH; Vitner, EB, 2012)
"Celecoxib has a positive effect on human osteoarthritic cartilage, but the mechanisms remain unclear."	1.38	Selective COX-2 inhibitor ameliorates osteoarthritis by repressing apoptosis of chondrocyte. ( An, H; Jiang, D; Luo, X; Ou, Y; Quan, Z; Tan, C; Tang, K, 2012)
"Ibuprofen treatment prevented the P3 HI-induced reductions in brain serotonin levels, serotonin transporter expression, and numbers of serotonergic neurons in the dorsal raphé nuclei on P10."	1.38	Post-insult ibuprofen treatment attenuates damage to the serotonergic system after hypoxia-ischemia in the immature rat brain. ( Buller, KM; Reinebrant, HE; Wixey, JA, 2012)
"Alzheimer's disease is a neurodegenerative pathology due to the presence of β-amyloid plaques at brain level and hippocampus level and associated with the loss of memory speech and learning."	1.37	NOS-mediated morphological and molecular modifications in rats infused with Aβ (1-40), as a model of Alzheimer's disease, in response to a new lipophilic molecular combination codrug-1. ( Cataldi, A; Cerasa, LS; Di Stefano, A; Nasuti, C; Patruno, A; Pesce, M; Rapino, M; Sozio, P; Zara, S, 2011)
"Ibuprofen treatment also prevented the HI-induced loss O4- and O1-positive oligodendrocyte progenitor cells and myelin basic protein (MBP)-positive myelin content one week after P3 HI."	1.37	Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia-ischemia in the immature rodent brain. ( Buller, KM; Carty, ML; Colditz, PB; Gobe, G; Reinebrant, HE; Wixey, JA, 2011)
"The prognosis of breast cancer in young women is influenced by reproductive history."	1.37	Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. ( Borges, VF; Conklin, MW; Eliceiri, KW; Keely, PJ; Lyons, TR; Marusyk, A; O'Brien, J; Schedin, P; Tan, AC, 2011)
"Paw volume, thermal hyperalgesia, mechanical allodynia, joint stiffness and mobility behaviors (score) were measured."	1.37	Anti-inflammatory and antihyperalgesic effects of the combination of ibuprofen and hemin in adjuvant-induced arthritis in the Wistar rat. ( Bijjem, KR; Kaur, S; Sharma, PL, 2011)
"Ibuprofen-treated APP23 mice performed significantly better than their sham-treated counterparts and almost attained the same level of performance as control animals on a complex visual-spatial learning task."	1.36	Ibuprofen modifies cognitive disease progression in an Alzheimer's mouse model. ( Coen, K; De Deyn, PP; Van Dam, D, 2010)
"Neuroinflammation was assessed by measuring activation of microglia and inflammatory factors."	1.36	Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. ( Agusti, A; Cauli, O; Felipo, V; Garcia-Verdugo, JM; Gomez-Pinedo, U; Hernandez-Rabaza, V; Rodrigo, R, 2010)
"Ibuprofen treatment for PDA closure in the preterm baboon neonate is not associated with any increased risk of neuropathology or alterations to brain growth and development."	1.36	Ibuprofen treatment for closure of patent ductus arteriosus is not associated with increased risk of neuropathology. ( Clyman, RI; Inder, TE; Loeliger, M; McCurnin, D; Rees, SM; Shields, A; Yoder, B, 2010)
"Ibuprofen plasma concentration reached a Cmax of 74."	1.36	Ibuprofen transdermal ethosomal gel: characterization and efficiency in animal models. ( Ainbinder, D; Bercovich, R; Duchi, S; Shumilov, M; Touitou, E, 2010)
"Ibuprofen was used as reference."	1.35	Antinociceptive activity of Buddleja globosa (matico) in several models of pain. ( Apablaza, C; Arrau, S; Backhouse, N; Castro, C; Delporte, C; Farías, M; Goïty, L; Miranda, H; Negrete, R, 2008)
"Ibuprofen was similar to the cyclooxygenase-1-selective inhibitor SC-560 in its ability to suppress the values of MVD of tumor tissues."	1.35	Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor. ( Li, W; Lin, ZY; Xu, RJ; Zhang, HH; Zhuo, GC, 2009)
"Treatment of mice with complete spinal cord transection demonstrates long-distance raphespinal axon regeneration in the presence of ibuprofen."	1.35	Ibuprofen enhances recovery from spinal cord injury by limiting tissue loss and stimulating axonal growth. ( Baughman, K; Budel, S; Gould, G; Song, KH; Strittmatter, SM; Wang, X, 2009)
"Indomethacin is used to close the patent ductus arteriosus in premature infants and for tocolysis of preterm labor."	1.35	Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat. ( Imamura, S; Ito, K; Momma, K; Nakanishi, T; Sugiyama, K; Sun, F; Toyoshima, K, 2009)
" Retrospective human epidemiological studies have identified long-term use of NSAIDs as protective against AD."	1.35	NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. ( Bhaskar, K; Herrup, K; Kounnas, MZ; Lamb, BT; Varvel, NH; Wagner, SL; Yang, Y, 2009)
"Ibuprofen-treated transgenic mice showed a significant decrease in intraneuronal oligomeric Abeta and hyperphosphorylated tau (AT8) immunoreactivity in the hippocampus."	1.35	Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. ( Carreras, I; Dedeoglu, A; Hossain, L; Jenkins, BG; Klein, WL; Kowall, NW; LaFerla, FM; McKee, AC; Oddo, S; Ryu, H, 2008)
"Neuritic plaques in the brain of Alzheimer's disease patients are characterized by beta-amyloid deposits associated with a glia-mediated inflammatory response."	1.33	Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. ( Dewachter, I; Dumitrescu-Ozimek, L; Hanke, A; Heneka, MT; Klockgether, T; Kuiperi, C; Landreth, GE; O'Banion, K; Sastre, M; Van Leuven, F, 2005)
"Ibuprofen was incorporated into ethylene-vinyl acetate (EVAc) polymers at 45% loading (wt:wt)."	1.33	Local delivery of ibuprofen via controlled-release polymers prevents angiographic vasospasm in a monkey model of subarachnoid hemorrhage. ( Clatterbuck, RE; Gailloud, P; Legnani, FG; Murphy, KP; Pradilla, G; Tamargo, RJ; Thai, QA, 2005)
"Treatment with ibuprofen, either before or after ETX, partly restored the elevated levels of nitrite/nitrate."	1.33	Ibuprofen reduces plasma nitrite/nitrate levels in a rabbit model of endotoxin-induced shock. ( Akbulut, H; Ayar, A; Canbaz, M; Celik, I; Vural, P, 2005)
"Mechanical allodynia and thermal hyperalgesia were evaluated in 108 Wistar rats allocated to: (1-4) NaCl 0."	1.33	Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. ( Beaulieu, P; Guindon, J, 2006)
" The antinociceptive efficacies were evaluated using several dose-response curves and time courses."	1.33	Enhancement of antinociception by co-administration of ibuprofen and caffeine in arthritic rats. ( Bravo, G; Cook, HJ; Déciga-Campos, M; Díaz-Reval, MI; Domínguez-Ramírez, AM; López, JR; López-Muñoz, FJ, 2006)
"Ibuprofen (IBU) was provided in a rodent chow (375 ppm) for animals 5-19 weeks of age."	1.33	Ibuprofen fails to prevent brain pathology in a model of neuropsychiatric lupus. ( Arsenault, L; Ballok, DA; Denburg, JA; Ma, X; Sakic, B, 2006)
"Ibuprofen treatment was compared with mild systemic hypothermia, which is known to be neuroprotective and is commonly used during neurosurgical procedures."	1.32	High-dose ibuprofen for reduction of striatal infarcts during middle cerebral artery occlusion in rats. ( Alkayed, NJ; Anderson, LG; Antezana, DF; Clatterbuck, RE; Frazier, J; Hurn, PD; Murphy, SJ; Tamargo, RJ; Traystman, RJ, 2003)
"Ibuprofen treatment reversed PGE2 levels in injured nerves and DRG, whereas celecoxib blocked increased PGE2 levels only in nerves."	1.32	Cyclooxygenase inhibition in nerve-injury- and TNF-induced hyperalgesia in the rat. ( Marziniak, M; Schäfers, M; Sommer, C; Sorkin, LS; Yaksh, TL, 2004)
"Ibuprofen is an antiinflammatory agent that inhibits the expression of specific cell adhesion molecules and, consequently, disrupts leukocyte-endothelial cell interactions."	1.32	Inhibition of cerebral vasospasm by intracranial delivery of ibuprofen from a controlled-release polymer in a rabbit model of subarachnoid hemorrhage. ( Frazier, JL; Pradilla, G; Tamargo, RJ; Wang, PP, 2004)
"Main parameter was thrombus weight."	1.32	Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model. ( Bégaud, B; Boisseau, M; Moore, N; Umar, A; Upur, H; Yusup, A, 2004)
"The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits."	1.31	Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000)
"Ursodiol, the drug of choice for the treatment of cystic fibrosis liver disease, may offer a safe method of using high-dose IBU in these patients by ameliorating the enteropathy."	1.31	Ursodeoxycholic acid ameliorates ibuprofen-induced enteropathy in the rat. ( Beno, DW; Jiyamapa-Serna, VA; Kimura, RE; Lloyd-Still, JD; Uhing, MR, 2001)
"Acetaminophen has no effect on the rate of tooth movement in rabbits undergoing orthodontic treatment."	1.30	The effect of acetaminophen on tooth movement in rabbits. ( Acs, G; Cisneros, GJ; Roche, JJ, 1997)
"Hydronephrosis was induced to permit direct visualization of renal microvessels."	1.29	Impairment of afferent arteriolar myogenic responsiveness in the galactose-fed rat. ( Epstein, M; Forster, HG; Hohman, TC; Takenaka, T; ter Wee, PM, 1994)
"Ibuprofen pretreatment increases arterial pressure and reduces mortality in endotoxic dogs."	1.28	Cardiovascular response in canine endotoxic shock: effect of ibuprofen pretreatment. ( Pinsky, MR, 1992)
"Ibuprofen treatment, either solely or in combination with influenza infection, did not produce significant change in the plasma levels of aspartate or ornithine aminotransferase activities."	1.28	Interactions of ibuprofen with influenza infection and hyperammonemia in an animal model of Reye's syndrome. ( Deshmukh, DR; Mukhopadhyay, A; Sarnaik, AP, 1992)
"Ibuprofen was used in an effort to manipulate infarct size as this agent has been shown to reduce ischaemia in myocardial infarction."	1.28	Unilateral carotid artery ligation in the Mongolian gerbil as a model for testing infarction-reducing therapies. ( Combs, DJ; Costello, L; Dempsey, RJ, 1990)
"Each ibuprofen-treated animal received a dose of 50 mg/kg either intraperitoneally or intravenously."	1.28	Effects of ibuprofen on pulmonary oedema in an animal smoke inhalation model. ( Chang, BL; Knost, PM; Mason, SW; Roshdieh, BB; Samadani, S; Stewart, RJ; Yamaguchi, KT, 1990)
"Treatment with ibuprofen or high-dose methylprednisolone after the first injection prevented or reduced vasospasm."	1.27	Prevention of chronic experimental cerebral vasospasm with ibuprofen and high-dose methylprednisolone. ( Chyatte, D; Rusch, N; Sundt, TM, 1983)
"In a canine endotoxic shock model (LD100), we studied the effects of opiate and prostaglandin inhibition 60 min after endotoxin administration."	1.27	The effects of vasoactive mediator antagonists on endotoxic shock in dogs. I. ( Hamburger, SA; Judy, WV; Toth, PD, 1984)
"Ibuprofen was more effective against the primary generalized model."	1.27	Attenuation of penicillin models of epilepsy by nonsteroidal anti-inflammatory drugs. ( Wallenstein, MC, 1987)
"Ibuprofen did not increase survival in this model."	1.27	The role of feces, necrotic tissue, and various blocking agents in the prevention of adhesions. ( Cha, SO; O'Leary, JP; Wickbom, A; Wickbom, G, 1988)
"Our prior work demonstrated in a canine endotoxic shock model (LD100) that the cyclooxygenase inhibitor ibuprofen given 60 minutes after endotoxin administration could improve hemodynamics but not survival over control animals."	1.27	Benoxaprofen attenuation of lethal canine endotoxic shock. ( Hamburger, SA; Hastings, GH; Judy, WV; Toth, PD, 1985)
"Ibuprofen and verapamil treatment resulted in less myocardial damage after 48 h than placebo treatment but the differences were generally not statistically significant."	1.27	Evaluation of a rat model for assessing interventions to salvage ischaemic myocardium: effects of ibuprofen and verapamil. ( Evans, RG; Fischer, VW; Kulevich, J; Mueller, HS; Val-Mejias, JE, 1985)
"Ibuprofen was more effective than indomethacin in the high mortality model (lethal dose for 90% survival of group)."	1.26	Improved survival in the suckling rat model of group B streptococcal sepsis after treatment with nonsteroidal anti-inflammatory drugs. ( Fletcher, JR; Miller, MK; Short, BL, 1982)
"In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow."	1.26	Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? ( Folts, JD; Gallagher, K; Rowe, GG, 1982)

Timeframe	Studies, this research(%)	All Research%
pre-1990	36 (14.12)	18.7374
1990's	26 (10.20)	18.2507
2000's	57 (22.35)	29.6817
2010's	115 (45.10)	24.3611
2020's	21 (8.24)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
Pioglitazone in Alzheimer Disease Progression[NCT00982202]	Phase 2	25 participants (Actual)	Interventional	2002-01-31	Completed
Biomarkers of Nonsteroidal Anti-Inflammatories[NCT00239746]	Phase 1	40 participants (Anticipated)	Interventional	2005-10-31	Active, not recruiting
Placebo-Controlled, Ascending Single-Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of CHF 5074 in Healthy Young Male Subjects[NCT00954252]	Phase 1	84 participants (Actual)	Interventional	2009-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Systematic review and meta-analysis of studies in which burrowing behaviour was assessed in rodent models of disease-associated persistent pain. Pain, 2022, 11-01, Volume: 163, Issue:11 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Disease M	2022
Genetics of the patent ductus arteriosus (PDA) and pharmacogenetics of PDA treatment. Seminars in fetal & neonatal medicine, 2018, Volume: 23, Issue:4 Topics: Acetaminophen; Animals; Disease Models, Animal; Ductus Arteriosus, Patent; Genetic Predisposition to	2018
The role of patent ductus arteriosus and its treatments in the development of bronchopulmonary dysplasia. Seminars in perinatology, 2013, Volume: 37, Issue:2 Topics: Animals; Bronchopulmonary Dysplasia; Cyclooxygenase Inhibitors; Disease Models, Animal; Ductus Arter	2013
Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review). Oncology reports, 2005, Volume: 13, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Case-Control Stu	2005
Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:12 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Animals, Genetically Modified; Anti-Inflammator	2005
The effects of ibuprofen on eicosanoid synthesis in sepsis. Critical care medicine, 1999, Volume: 27, Issue:4 Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Cytokines; Disease Models, Anima	1999

Article	Year
A randomized controlled trial of a combination of antiviral and nonsteroidal anti-inflammatory treatment in a bovine model of respiratory syncytial virus infection. PloS one, 2020, Volume: 15, Issue:3 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Cattle; Disease Models, Animal;	2020
A Randomized Placebo Controlled Trial of Ibuprofen for Respiratory Syncytial Virus Infection in a Bovine Model. PloS one, 2016, Volume: 11, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Cattle Diseases; Cytokines; Disease Models	2016

ibuprofen and Disease Models, Animal

Research Excerpts

Research

Studies (255)

Authors

Clinical Trials (3)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Wilkerson, WW	1
Galbraith, W	1
Gans-Brangs, K	1
Grubb, M	1
Hewes, WE	1
Jaffee, B	1
Kenney, JP	1
Kerr, J	1
Wong, N	1
Stock, N	1
Munoz, B	1
Wrigley, JD	1
Shearman, MS	1
Beher, D	1
Peachey, J	1
Williamson, TL	1
Bain, G	1
Chen, W	1
Jiang, X	1
St-Jacques, R	1
Prasit, P	1
Molvi, KI	1
Vasu, KK	2
Yerande, SG	1
Sudarsanam, V	2
Haque, N	1
Chatterjee, NR	1
Kulkarni, AA	1
Ghulekar, SP	1
Avdeef, A	1
Tam, KY	1
Fowler, CJ	1
Björklund, E	1
Lichtman, AH	1
Naidu, PS	1
Congiu, C	1
Onnis, V	1
Liu, W	1
Zhou, J	1
Zhang, T	1
Zhu, H	1
Qian, H	1
Zhang, H	2
Huang, W	1
Gust, R	1
Li, Y	2
Liu, YB	1
Zhang, JJ	1
Liu, Y	2
Ma, SG	1
Qu, J	1
Lv, HN	1
Yu, SS	1
Lee, HH	1
Shin, JS	1
Lee, WS	1
Ryu, B	1
Jang, DS	1
Lee, KT	1
Wu, YJ	1
Guernon, J	1
McClure, A	1
Luo, G	1
Rajamani, R	1
Ng, A	1
Easton, A	1
Newton, A	1
Bourin, C	1
Parker, D	1
Mosure, K	1
Barnaby, O	1
Soars, MG	1
Knox, RJ	1
Matchett, M	1
Pieschl, R	1
Herrington, J	1
Chen, P	2
Sivarao, DV	1
Bristow, LJ	1
Meanwell, NA	1
Bronson, J	1
Olson, R	1
Thompson, LA	1
Dzierba, C	1
Solinski, HJ	1
Dranchak, P	1
Oliphant, E	1
Gu, X	1
Earnest, TW	1
Braisted, J	1
Inglese, J	1
Hoon, MA	1
Koppitz, M	1
Bräuer, N	1
Ter Laak, A	1
Irlbacher, H	1
Rotgeri, A	1
Coelho, AM	2
Walter, D	1
Steinmeyer, A	1
Zollner, TM	1
Peters, M	1
Nagel, J	1
Abrams, RPM	1
Yasgar, A	1
Teramoto, T	1
Lee, MH	1
Dorjsuren, D	1
Eastman, RT	1
Malik, N	1
Zakharov, AV	1
Li, W	2
Bachani, M	1
Brimacombe, K	1
Steiner, JP	1
Hall, MD	1
Balasubramanian, A	1
Jadhav, A	1
Padmanabhan, R	1
Simeonov, A	1
Nath, A	1
Taghipour, F	2
Oladpour, O	2
Rezayati, MT	2
Khorramdelazad, H	1
Nemati, M	2
Taghipour, Z	2
Masoumi, J	1
Hassan, ZM	2
Jafarzadeh, A	2
Bandarkar, F	1
Masocha, W	1
Nada, A	1
Herz, H	1
Song, Y	1
Ye, Y	1
Tian, L	1
Linden, B	1
Abu El Haija, M	1
Chu, Y	1
Grobe, JL	1
Lengeling, RW	1
Mokadem, M	1
Zhang, XY	1
Barakat, A	1
Diaz-delCastillo, M	1
Vollert, J	1
Sena, ES	1
Heegaard, AM	1
Rice, ASC	1
Soliman, N	1
Quintão, NLM	2
Reis, JP	2
Benvenutti, L	1
Nunes, R	1
Goldoni, FC	1
Cozer, MS	1
de Souza, P	1
de Cássia Melo Vilhena de Andrade Fonseca da Silva, R	1
Melato, J	1
Vaz, CR	1
Whitaker, JCP	2
Jesuíno, FW	1
Costa, MC	1
Pastor, MVD	2
Malheiros, A	1
Meyre-Silva, C	1
Santin, JR	1
Rotpenpian, N	1
Wanasuntronwong, A	1
Tapechum, S	1
Vattarakorn, A	1
Care, C	1
Chindasri, W	1
Tilokskulchai, K	1
Tantisira, MH	1
Pakaprot, N	1
Mortensen, R	1
Clemmensen, HS	1
Woodworth, JS	1
Therkelsen, ML	1
Mustafa, T	1
Tonby, K	1
Jenum, S	1
Agger, EM	1
Dyrhol-Riise, AM	1
Andersen, P	1
Mesripour, A	1
Shahnooshi, S	1
Hajhashemi, V	1
Chen, CT	1
Chen, CH	1
Sheu, C	1
Chen, JP	1
Haupenthal, DPDS	1
Dias, FM	1
Zaccaron, RP	1
Silveira, GB	1
Corrêa, MEAB	1
Mendes, C	1
Casagrande, LR	1
Pinho, RA	1
de Andrade, TAM	1
Feuser, PE	1
Paula, MMDS	1
Silveira, PCL	1
Qu, Z	1
Liu, L	2
Sun, T	1
Hou, J	1
Sun, Y	1
Yu, M	1
Diao, Y	1
Lu, S	1
Zhao, W	1
Wang, L	2
Walsh, P	2
Lebedev, M	1
McEligot, H	2
Mutua, V	1
Bang, H	1
Gershwin, LJ	2
Sato, N	1
Yako, Y	1
Maruyama, T	1
Ishikawa, S	1
Kuromiya, K	1
Tokuoka, SM	1
Kita, Y	1
Fujita, Y	1
Taylor, BL	1
Kim, DH	1
Huegel, J	1
Raja, HA	1
Burkholder, SJ	1
Weiss, SN	1
Nuss, CA	1
Soslowsky, LJ	3
Mauck, RL	2
Kuntz, AF	2
Bernstein, J	2
Wei, L	1
Gao, C	1
Qian, C	1
Xi, K	1
Ruan, H	1
Yu, J	1
Luo, ZP	1
Cui, W	1
Chai, Z	1
Teng, C	1
Yang, L	2
Ren, L	1
Yuan, Z	1
Xu, S	1
Cheng, M	1
Wang, Y	1
Yan, Z	1
Qin, C	1
Han, X	1
Yin, L	1
Prieto-García, L	1
Vicente-Vicente, L	1
Blanco-Gozalo, V	1
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Chen, CY	2
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Chen, CS	2
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ter Wee, PM	1
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