Compounds > ibuprofen
Page last updated: 2024-10-28

ibuprofen and Dermatitis Medicamentosa

ibuprofen has been researched along with Dermatitis Medicamentosa in 45 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
" Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made."7.81Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen. ( Abe, M; Aritomo, K; Hiasa, Y; Hirooka, M; Ikeda, Y; Koizumi, Y; Kumagi, T; Matsuura, B; Ochi, H; Tada, F; Tokumoto, Y; Watanabe, T, 2015)
"Acute generalized exanthematic pustulosis (AGEP) is characterized by a generalized rash and sterile disseminated, sometimes coalescing subcorneal pustules."5.35Acute localized exanthematous pustulosis (ALEP) caused by Ibuprofen. A case report. ( Dhawan, V; Modi, M; Rastogi, S, 2009)
" Drug lymphocyte stimulation tests implicated ibuprofen, a main component of the OTC drugs, which has the potential to induce this pathology, and a diagnosis of drug-induced liver injury with multiform exudative erythema was made."3.81Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen. ( Abe, M; Aritomo, K; Hiasa, Y; Hirooka, M; Ikeda, Y; Koizumi, Y; Kumagi, T; Matsuura, B; Ochi, H; Tada, F; Tokumoto, Y; Watanabe, T, 2015)
"Since its introduction in the United States in 1974, ibuprofen (Motrin, Upjohn) has been shown to be safe and effective for the treatment of pain, dysmenorrhea, inflammation, and fever."2.65Safety profile: fifteen years of clinical experience with ibuprofen. ( Royer, GL; Seckman, CE; Welshman, IR, 1984)
"Fixed drug eruptions (FDEs) are adverse drug reactions manifesting in the skin after exposure to a certain drug."1.91MULTIFOCAL FIXED DRUG ERUPTION MIMICKING ACQUIRED DERMAL MELANOCYTOSIS. ( Cardoso, JC; Kordeva, S; Tchernev, G, 2023)
"Fixed drug eruptions (FDE) comprise 10 percent of alladverse cutaneous drug reactions and generalizedbullous fixed drug eruptions (GBFDE) are a raresubset of FDEs."1.46Generalized bullous fixed drug eruption treated with cyclosporine. ( Cyrus, N; Malviya, N; Mauskar, M; Vandergriff, T, 2017)
"Fixed drug eruptions (FDE) are peculiar drug rashes that tend to be violaceous, hyperpigmented, and round to oval-shaped plaques with dusky gray centers."1.42Bullous fixed drug eruption masquerading as recurrent Stevens Johnson syndrome. ( Dharamsi, FM; Dharamsi, JW; Michener, MD, 2015)
"Fixed drug eruptions often have a characteristic appearance, which, when correlated with the clinical history, can be easily identified."1.38Multifocal, fixed-drug eruption masquerading as recurrent erythema multiforme. ( Elm, MK; Murchland, MR, 2012)
"Fixed drug eruptions (FDEs), first described by Bourns in 1889, are solitary or multiple, sharply demarcated, round to oval, edematous and erythematous patches that arise after exposure to a specific medication."1.38Fixed drug eruption related to ibuprofen presenting as giant bullae on the posterior thigh. ( Fleming, KF; Grekin, SJ; Koshelev, MV; Wasko, CA, 2012)
"Acute generalized exanthematic pustulosis (AGEP) is characterized by a generalized rash and sterile disseminated, sometimes coalescing subcorneal pustules."1.35Acute localized exanthematous pustulosis (ALEP) caused by Ibuprofen. A case report. ( Dhawan, V; Modi, M; Rastogi, S, 2009)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-19907 (15.56)18.7374
1990's5 (11.11)18.2507
2000's13 (28.89)29.6817
2010's13 (28.89)24.3611
2020's7 (15.56)2.80

Authors

AuthorsStudies
Kordeva, S1
Cardoso, JC1
Tchernev, G1
Ota, M1
Bhanja, DB1
Sil, A1
Panigrahi, A1
Chakraborty, S1
Jamiolkowski, D1
Steveling-Klein, E1
Scherer Hofmeier, K1
Hartmann, K1
Topal, OY1
Ilknur, KC1
Irem, YT1
Muge, T1
Ersoy, C1
Betul, K1
Emine, DM1
Liccioli, G1
Filippeschi, C1
Giovannini, M1
Capone, M1
Oranges, T1
Barni, S1
Sarti, L1
Parronchi, P1
Mori, F1
Reguero Capilla, M1
De Aramburu Mera, T1
Ochando Díez-Canseco, M1
Prados Castaño, M1
Malviya, N1
Cyrus, N1
Vandergriff, T1
Mauskar, M1
Beà-Ardébol, S1
Gómez-Zubiaur, A1
Cabrera-Hernández, A1
Trasobares-Marugán, L1
Maganji, M1
Connolly, MP1
Bhatt, A1
Hernandez-Aragues, I1
Vilas-Boas, P1
Bergón-Sendín, M1
Parra-Blanco, V1
Simal-Gómez, G1
Tavares Almeida, F1
Caldas, R1
André Oliveira, Á1
Pardal, J1
Pereira, T1
Brito, C1
Arochena, L1
Zafra, MP1
Fariña, MC1
Del Pozo, V1
Fernández-Nieto, M1
Atanasković-Marković, M1
Medjo, B1
Gavrović-Jankulović, M1
Ćirković Veličković, T1
Nikolić, D1
Nestorović, B1
Dharamsi, FM1
Michener, MD1
Dharamsi, JW1
Watanabe, T1
Abe, M1
Tada, F1
Aritomo, K1
Ochi, H1
Koizumi, Y1
Tokumoto, Y1
Hirooka, M1
Kumagi, T1
Ikeda, Y1
Matsuura, B1
Hiasa, Y1
Rastogi, S1
Modi, M1
Dhawan, V1
Santiago Sánchez-Mateos, JL1
Aboín González, S1
Beà Ardébol, S1
Carrillo Gijón, R1
Muñoz Zato, E1
Jaén Olasolo, P1
Kasemsarn, P1
Kulthanan, K1
Tuchinda, P1
Dhana, N1
Jongjarearnprasert, K1
Elm, MK1
Murchland, MR1
Chen, JF1
Chiang, CP1
Koshelev, MV1
Fleming, KF1
Grekin, SJ1
Wasko, CA1
Al Aboud, K1
Ramesh, V1
Al Hawsawi, K1
Yesudian, PD1
Penny, M1
Azurdia, RM1
King, CM1
Sánchez-Borges, M1
Capriles-Hulett, A1
Caballero-Fonseca, F1
Kucharewicz, I1
Kemona-Chetnik, I1
Reduta, T1
Wierzbicka, I1
Flisiak, R1
Bodzenta-Lukaszyk, A1
Royer, GL1
Seckman, CE1
Welshman, IR1
Kanwar, AJ1
Belhaj, MS2
Bharija, SC2
Mohammed, M1
Sternlieb, P1
Robinson, RM1
Sanclemente, G1
De la Roche, CA1
Escobar, CE1
Falabella, R1
Bielan, B1
Takahama, H1
Kubota, Y1
Mizoguchi, M1
Clénin, GE1
van Rooijen, MM1
Braathen, LR1
Descamps, V1
Valance, A1
Edlinger, C1
Fillet, AM1
Grossin, M1
Lebrun-Vignes, B1
Belaich, S1
Crickx, B1
Davidson, KA1
Ringpfeil, F1
Lee, JB1
Krasowska, D1
Schwartz, RA1
Lecewicz-Torun, B1
Fasching, U1
Eberl, R1
Bergner, T1
Przybilla, B1
Kuligowski, ME1
Chang, A1
Rath, R1
Veronesi, S1
de Padova, MP1
Bardazzi, F1
Melino, M1
Shelley, ED1
Shelley, WB1
Bigby, M1
Stern, R1

Reviews

2 reviews available for ibuprofen and Dermatitis Medicamentosa

ArticleYear
Risk of skin reactions when using ibuprofen-based medicines.
    Expert opinion on drug safety, 2005, Volume: 4, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Drug Eruptions; Economics, Pharmaceutical; Humans; I

2005
Cutaneous reactions to nonsteroidal anti-inflammatory drugs. A review.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:5 Pt 1

    Topics: Acetates; Anti-Inflammatory Agents; Aspirin; Drug Eruptions; Humans; Ibuprofen; Indomethacin; ortho-

1985

Trials

3 trials available for ibuprofen and Dermatitis Medicamentosa

ArticleYear
Cutaneous irritancy of an ibuprofen medicated plaster in healthy volunteers.
    Postgraduate medicine, 2018, Volume: 130, Issue:3

    Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Bandages; Double-Blind Me

2018
Safety profile: fifteen years of clinical experience with ibuprofen.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: Anti-Inflammatory Agents; Aspirin; Blood Cell Count; Blood Coagulation Tests; Blood Proteins; Centra

1984
[Sulindac: Clinical test of a new antiinflammatory agent in rheumatoid arthritis (author's transl)].
    Wiener klinische Wochenschrift. Supplementum, 1976, Volume: 59

    Topics: Adult; Aged; Alopecia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzylidene Compoun

1976

Other Studies

40 other studies available for ibuprofen and Dermatitis Medicamentosa

ArticleYear
MULTIFOCAL FIXED DRUG ERUPTION MIMICKING ACQUIRED DERMAL MELANOCYTOSIS.
    Georgian medical news, 2023, Issue:335

    Topics: Drug Eruptions; Humans; Ibuprofen; Skin

2023
Painful and Pruritic Blisters on the Lower Lip.
    JAMA, 2020, Jan-07, Volume: 323, Issue:1

    Topics: Adult; Blister; Drug Eruptions; Female; Humans; Ibuprofen; Lip; Patch Tests

2020
Ibuprofen-induced generalised bullous fixed drug eruption.
    Postgraduate medical journal, 2020, Volume: 96, Issue:1141

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Drug Eruptions; Humans; Ibuprofen;

2020
Multilocular bullous fixed drug eruption elicited by paracetamol and migraine attacks, but not by paracetamol alone.
    Contact dermatitis, 2020, Volume: 83, Issue:3

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Blister; Dr

2020
Negative predictive value of provocation tests for nonsteroidal anti-inflammatory drugs in children.
    Allergy and asthma proceedings, 2020, 07-01, Volume: 41, Issue:4

    Topics: Acetaminophen; Administration, Oral; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Child; Chi

2020
Mycoplasma pneumoniae-associated mucocutaneous disease in children: A case series with allergy workup in a tertiary care paediatric hospital.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2021, Volume: 51, Issue:5

    Topics: Acetaminophen; Adolescent; Analgesics, Non-Narcotic; Anti-Bacterial Agents; Child; Child, Preschool;

2021
Fixed Drug Eruption After Ingestion of Naproxen in a Patient Who Tolerated Ibuprofen and Dexketoprofen.
    Journal of investigational allergology & clinical immunology, 2021, Volume: 31, Issue:2

    Topics: Administration, Oral; Adult; Allergens; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Fem

2021
Generalized bullous fixed drug eruption treated with cyclosporine.
    Dermatology online journal, 2017, Feb-15, Volume: 23, Issue:2

    Topics: Administration, Intravenous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blister; Cyclosporine;

2017
Non-infectious genital ulcer: The relevance of anamnesis.
    Medicina clinica, 2017, 09-08, Volume: 149, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Humans; Ibuprofen; Male; Medical His

2017
Cutaneous Drug Reactions: typical and atypical cases of a distinctive drug reaction.
    European journal of dermatology : EJD, 2018, Jun-01, Volume: 28, Issue:3

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Drug

2018
Generalized bullous fixed drug eruption caused by ibuprofen.
    Contact dermatitis, 2019, Volume: 80, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Blister; Drug Eruptions; Female; Humans; Ibuprofen;

2019
Acute generalized exanthematic pustulosis due to ibuprofen.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2013, Volume: 110, Issue:5

    Topics: Acute Generalized Exanthematous Pustulosis; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-

2013
Stevens-Johnson syndrome and toxic epidermal necrolysis in children.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2013, Volume: 24, Issue:7

    Topics: Adrenal Cortex Hormones; Allergens; Carbamazepine; Ceftriaxone; Child; Child, Preschool; Drug Erupti

2013
Bullous fixed drug eruption masquerading as recurrent Stevens Johnson syndrome.
    The Journal of emergency medicine, 2015, Volume: 48, Issue:5

    Topics: Adult; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Blister; Diagnosis, Different

2015
Drug-induced liver injury with serious multiform exudative erythema following the use of an over-the-counter medication containing ibuprofen.
    Internal medicine (Tokyo, Japan), 2015, Volume: 54, Issue:4

    Topics: Adult; Asian People; Chemical and Drug Induced Liver Injury; Drug Eruptions; Erythema; Female; Fever

2015
Acute localized exanthematous pustulosis (ALEP) caused by Ibuprofen. A case report.
    The British journal of oral & maxillofacial surgery, 2009, Volume: 47, Issue:2

    Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Exanthema; Facial Dermatoses

2009
[Recurrent purpuric lesion on back of hand].
    Revista clinica espanola, 2009, Volume: 209, Issue:1

    Topics: Analgesics, Non-Narcotic; Drug Eruptions; Hand Dermatoses; Humans; Ibuprofen; Male; Middle Aged; Pur

2009
Cutaneous reactions to non-steroidal anti-inflammatory drugs.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Cel

2011
Multifocal, fixed-drug eruption masquerading as recurrent erythema multiforme.
    Journal of drugs in dermatology : JDD, 2012, Volume: 11, Issue:2

    Topics: Acetaminophen; Adolescent; Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Female; Hum

2012
Dermacase. Can you identify this condition? Generalized fixed drug eruption.
    Canadian family physician Medecin de famille canadien, 2012, Volume: 58, Issue:6

    Topics: Aged; Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Humans; Ibuprofen; Male; Pemphig

2012
Fixed drug eruption related to ibuprofen presenting as giant bullae on the posterior thigh.
    Dermatology online journal, 2012, Nov-15, Volume: 18, Issue:11

    Topics: Analgesics, Non-Narcotic; Blister; Drug Eruptions; Humans; Ibuprofen; Male; Middle Aged; Thigh

2012
Fixed drug eruption to ibuprofen in daughter and father.
    Journal of drugs in dermatology : JDD, 2003, Volume: 2, Issue:6

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Drug Eruptions;

2003
Ibuprofen-induced acute generalized exanthematous pustulosis.
    International journal of dermatology, 2004, Volume: 43, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Buttocks; Diagnosis, Differential;

2004
Immunizations. Can fever-reducers prevent redness from DTP shots?
    Child health alert, 2006, Volume: 24

    Topics: Acetaminophen; Anti-Inflammatory Agents; Child; Diphtheria-Tetanus-Pertussis Vaccine; Drug Eruptions

2006
Drug rash with eosinophilia and systemic symptoms after ibuprofen intake.
    Journal of investigational allergology & clinical immunology, 2007, Volume: 17, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Eosinophilia; Exanthema; Humans; Ibu

2007
Drugs causing fixed eruptions.
    The Journal of dermatology, 1984, Volume: 11, Issue:4

    Topics: Adult; Aspirin; Butylscopolammonium Bromide; Cross Reactions; Dipyrone; Drug Eruptions; Drug Interac

1984
Side effects of ibuprofen.
    Annals of internal medicine, 1980, Volume: 92, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Drug Eruptions; Humans; Ibuprofen

1980
Pentoxyfylline in toxic epidermal necrolysis and Stevens-Johnson syndrome.
    International journal of dermatology, 1999, Volume: 38, Issue:11

    Topics: Child, Preschool; Drug Eruptions; Female; Humans; Ibuprofen; Male; Pentoxifylline; Stevens-Johnson S

1999
What's your assessment? Fixed drug eruption.
    Dermatology nursing, 1999, Volume: 11, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Drug Eruptions; Female; Humans; Ib

1999
A case of anaphylaxis due to ibuprofen.
    The Journal of dermatology, 2000, Volume: 27, Issue:5

    Topics: Adult; Anaphylaxis; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Drug Eruptions

2000
[Ibuprofen-induced, transient ANA- and anti-histone positive leukocytoclastic vasculitis].
    Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2000, Volume: 51, Issue:9

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Antinuclear; Drug Eruptions; Female; Histones;

2000
Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms.
    Archives of dermatology, 2001, Volume: 137, Issue:3

    Topics: Adult; Antibodies, Viral; Carbamazepine; DNA, Viral; Drug Eruptions; Eosinophilia; Herpesviridae Inf

2001
Ibuprofen-induced bullous leukocytoclastic vasculitis.
    Cutis, 2001, Volume: 67, Issue:4

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Drug Eruptions; Female; Huma

2001
Cutaneous drug reaction case reports: from the world literature.
    American journal of clinical dermatology, 2001, Volume: 2, Issue:4

    Topics: Adolescent; Adverse Drug Reaction Reporting Systems; Aged; Amlodipine; Anti-Bacterial Agents; Anti-I

2001
Generalized lichenoid drug eruption following Blaschko lines.
    International journal of dermatology, 2001, Volume: 40, Issue:12

    Topics: Adolescent; Drug Eruptions; Female; Humans; Ibuprofen; Lichenoid Eruptions

2001
Photosensitization caused by ibuprofen.
    Journal of the American Academy of Dermatology, 1992, Volume: 26, Issue:1

    Topics: Adult; Drug Eruptions; Female; Humans; Ibuprofen; Photosensitivity Disorders

1992
Multiple fixed drug eruption due to ibuprofen.
    Contact dermatitis, 1991, Volume: 25, Issue:4

    Topics: Drug Eruptions; Female; Humans; Ibuprofen; Middle Aged; Pigmentation Disorders

1991
Fixed drug eruption on three independent sites induced by three chemically unrelated drugs.
    Dermatologica, 1990, Volume: 181, Issue:3

    Topics: Adult; Ampicillin; Aspirin; Drug Eruptions; Humans; Ibuprofen; Male; Skin

1990
Contact dermatitis to ibuprofen.
    Contact dermatitis, 1986, Volume: 15, Issue:2

    Topics: Aged; Dermatitis, Contact; Drug Eruptions; Humans; Ibuprofen; Male; Patch Tests

1986
Ibuprofen urticaria.
    Journal of the American Academy of Dermatology, 1987, Volume: 17, Issue:6

    Topics: Adolescent; Adult; Anaphylaxis; Drug Eruptions; Female; Humans; Ibuprofen; Male; Middle Aged; Urtica

1987