ibuprofen has been researched along with Depression in 16 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors." | 8.02 | The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021) |
| " The aim of the present study was to clarify whether plant-derived isoflavone puerarin could ameliorate comorbid depression and pain." | 7.85 | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). ( Lao, L; Liang, Z; Luo, D; Rong, J; Zhao, J, 2017) |
| "Ibuprofen treatment reduced skeletal muscle wasting, inflammation in the brain, and fatigue- and depressive-like behavior in tumor-bearing mice." | 7.81 | Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. ( Bicer, S; Devine, RD; Godbout, JP; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 5.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors." | 4.02 | The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021) |
| " The aim of the present study was to clarify whether plant-derived isoflavone puerarin could ameliorate comorbid depression and pain." | 3.85 | Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI). ( Lao, L; Liang, Z; Luo, D; Rong, J; Zhao, J, 2017) |
| "Ibuprofen treatment reduced skeletal muscle wasting, inflammation in the brain, and fatigue- and depressive-like behavior in tumor-bearing mice." | 3.81 | Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. ( Bicer, S; Devine, RD; Godbout, JP; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| " Future clinical trials should investigate this association with maximum dosage of drugs, increased treatment duration, and monitoring of social and environmental changes." | 2.78 | NSAIDs are associated with lower depression scores in patients with osteoarthritis. ( Aneja, A; Farkouh, ME; Gandhi, S; Greenberg, J; Iyengar, RL; Mosovich, S; Razzouk, L; Thorpe, K, 2013) |
| "A 14-year-old girl with systemic lupus erythematosus presented with a mixed overdose of paracetamol, ibuprofen and azathioprine (1500 mg) following a deliberate self-harm attempt." | 2.49 | Intentional overdose of azathioprine in a patient with systemic lupus erythematosus. ( Khan, AM; Mahmood, K; Martin, K; Ramanan, AV, 2013) |
| "Depression was induced by IFNα (16 × 105 IU/kg, SC) for six consecutive days." | 1.51 | Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice. ( Hajhashemi, V; Mesripour, A; Shahnooshi, S, 2019) |
| "Post treatment with ibuprofen blocked the depletion of glutathione induced by rotenone and increased the basal levels of this antioxidant in the striatum." | 1.40 | Antidepressant and antioxidative effect of Ibuprofen in the rotenone model of Parkinson's disease. ( Baggio, CH; Barbiero, JK; Bassani, TB; Gradowski, RW; Maria-Ferreira, D; Santiago, RM; Vital, MA; Zaminelli, T, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Vivier, D | 1 |
| Bennis, K | 1 |
| Lesage, F | 1 |
| Ducki, S | 1 |
| Mesripour, A | 1 |
| Shahnooshi, S | 1 |
| Hajhashemi, V | 1 |
| Gaebler, AJ | 1 |
| Schoretsanitis, G | 1 |
| Ben Omar, N | 1 |
| Haen, E | 1 |
| Endres, K | 1 |
| Hiemke, C | 1 |
| Paulzen, M | 1 |
| Salmani, H | 1 |
| Hosseini, M | 1 |
| Baghcheghi, Y | 1 |
| Samadi-Noshahr, Z | 1 |
| Seo, MK | 1 |
| Lee, JG | 1 |
| Park, SW | 1 |
| Iyengar, RL | 1 |
| Gandhi, S | 1 |
| Aneja, A | 1 |
| Thorpe, K | 1 |
| Razzouk, L | 1 |
| Greenberg, J | 1 |
| Mosovich, S | 1 |
| Farkouh, ME | 1 |
| Mahmood, K | 1 |
| Khan, AM | 1 |
| Ramanan, AV | 1 |
| Martin, K | 1 |
| Zaminelli, T | 1 |
| Gradowski, RW | 1 |
| Bassani, TB | 1 |
| Barbiero, JK | 1 |
| Santiago, RM | 1 |
| Maria-Ferreira, D | 1 |
| Baggio, CH | 1 |
| Vital, MA | 1 |
| Saleh, LA | 1 |
| Hamza, M | 1 |
| El Gayar, NH | 1 |
| Abd El-Samad, AA | 1 |
| Nasr, EA | 1 |
| Masoud, SI | 1 |
| Norden, DM | 1 |
| McCarthy, DO | 1 |
| Bicer, S | 1 |
| Devine, RD | 1 |
| Reiser, PJ | 1 |
| Godbout, JP | 1 |
| Wold, LE | 1 |
| da Silva Dias, IC | 1 |
| Carabelli, B | 1 |
| Ishii, DK | 1 |
| de Morais, H | 1 |
| de Carvalho, MC | 1 |
| Rizzo de Souza, LE | 1 |
| Zanata, SM | 1 |
| Brandão, ML | 1 |
| Cunha, TM | 1 |
| Ferraz, AC | 1 |
| Cunha, JM | 1 |
| Zanoveli, JM | 1 |
| Zhao, J | 1 |
| Luo, D | 1 |
| Liang, Z | 1 |
| Lao, L | 1 |
| Rong, J | 1 |
| Rudin, A | 1 |
| Eriksson, L | 1 |
| Liedholm, R | 1 |
| List, T | 1 |
| Werner, MU | 1 |
| Strain, WD | 1 |
| Lye, M | 1 |
| Iveson-Iveson, J | 1 |
| Russell, IJ | 1 |
| Fletcher, EM | 1 |
| Michalek, JE | 1 |
| McBroom, PC | 1 |
| Hester, GG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Placebo-controlled, Dose-response Study of Ibuprofen Effects on Brain Function[NCT02507219] | Phase 2/Phase 3 | 24 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| Salicylic Augmentation in Depression[NCT03152409] | Phase 2 | 74 participants (Anticipated) | Interventional | 2018-11-15 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in amygdala activation following administration of placebo, 200mg of ibuprofen or 600mg of ibuprofen (NCT02507219)
Timeframe: 3-6 weeks
| Intervention | percent signal change (Mean) | |
|---|---|---|
| Left amygdala | Right amygdala | |
| Ibuprofen, 200mg | 0.21 | 0.23 |
| Ibuprofen, 600mg | 0.23 | 0.17 |
| Placebo | 0.20 | 0.23 |
2 reviews available for ibuprofen and Depression
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
Intentional overdose of azathioprine in a patient with systemic lupus erythematosus.
Topics: Acetaminophen; Adolescent; Affective Disorders, Psychotic; Anti-Inflammatory Agents, Non-Steroidal; | 2013 |
2 trials available for ibuprofen and Depression
| Article | Year |
|---|---|
NSAIDs are associated with lower depression scores in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Depression; Doub | 2013 |
NSAIDs are associated with lower depression scores in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Depression; Doub | 2013 |
NSAIDs are associated with lower depression scores in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Depression; Doub | 2013 |
NSAIDs are associated with lower depression scores in patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Depression; Doub | 2013 |
Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam. A double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Alprazolam; Depression; Double-Blind Method; Fibromyalgia; Humans; Ibuprofe | 1991 |
12 other studies available for ibuprofen and Depression
| Article | Year |
|---|---|
Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Depression; Disease M | 2019 |
Metamizole but not ibuprofen reduces the plasma concentration of sertraline: Implications for the concurrent treatment of pain and depression/anxiety disorders.
Topics: Anxiety Disorders; Depression; Dipyrone; Humans; Ibuprofen; Pain, Postoperative; Selective Serotonin | 2021 |
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Animal; | 2021 |
Effects of escitalopram and ibuprofen on a depression-like phenotype induced by chronic stress in rats.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor | 2019 |
Antidepressant and antioxidative effect of Ibuprofen in the rotenone model of Parkinson's disease.
Topics: Animals; Antidepressive Agents; Antioxidants; Brain; Catalase; Depression; Dose-Response Relationshi | 2014 |
Ibuprofen suppresses depressive like behavior induced by BCG inoculation in mice: role of nitric oxide and prostaglandin.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; BCG Vaccine; Brain Chemistry; Depression; Dinopros | 2014 |
Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Depression; Fatigue; Female; Ib | 2015 |
Indoleamine-2,3-Dioxygenase/Kynurenine Pathway as a Potential Pharmacological Target to Treat Depression Associated with Diabetes.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blood Glucose; Cytokines; Depression; Diabetes Mel | 2016 |
Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI).
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biological Products; Brain-Derived Neurotrophic Fa | 2017 |
Prediction of postoperative pain after mandibular third molar surgery.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anxiety; Attitude; Depression; Eating; Female; Follo | 2010 |
Chronic pain, bereavement and overdose in a depressed elderly woman.
Topics: Acetaminophen; Aged; Aged, 80 and over; Aging; Aortic Aneurysm, Thoracic; Aspirin; Back Pain; Bereav | 2002 |
Disease: its cause and effect. 10: Iatrogenic disease.
Topics: Aged; Amitriptyline; Confusion; Depression; Humans; Iatrogenic Disease; Ibuprofen; Male; Nursing Ass | 1979 |