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ibuprofen and Delayed Effects, Prenatal Exposure

ibuprofen has been researched along with Delayed Effects, Prenatal Exposure in 19 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, such as acetaminophen (APAP), are frequently taken during pregnancy, even in combination."7.91In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. ( Boizet-Bonhoure, B; Brun, C; de Massy, B; Déjardin, S; Ghettas, A; Keime, C; Marchive, C; Nguyen, AL; Ollivier, M; Philibert, P; Poulat, F; Pruvost, A; Rossitto, M, 2019)
" We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child."7.88Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. ( Andersen, AN; Andersen, GL; Andersen, PK; Liew, Z; Martinussen, T; Olsen, J; Petersen, TG; Rebordosa, C; Strandberg-Larsen, K; Tollånes, MC; Uldall, P; Wilcox, AJ, 2018)
"Ibuprofen exposure during the first trimester was associated with a decrease in birth weight of 79 grams (95% confidence interval -133 to -25 grams)."7.83Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study. ( Nezvalová-Henriksen, K; Nordeng, H; Spigset, O; Wood, M, 2016)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."7.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
" Up to the present day, several cases of severe and sometimes irreversible renal insufficiency have been described in neonates exposed to indomethacin prenatally or in the first days of life for treatment of patent ductus arteriosus (PDA)."4.81NSAID-induced nephrotoxicity from the fetus to the child. ( Cuzzolin, L; Dal Cerè, M; Fanos, V, 2001)
"Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children."3.96Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour. ( Bertoldi, AD; Cardenas, A; Hivert, MF; Oken, E; Rifas-Shiman, SL; Tiemeier, H, 2020)
"Nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic drugs, such as acetaminophen (APAP), are frequently taken during pregnancy, even in combination."3.91In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice. ( Boizet-Bonhoure, B; Brun, C; de Massy, B; Déjardin, S; Ghettas, A; Keime, C; Marchive, C; Nguyen, AL; Ollivier, M; Philibert, P; Poulat, F; Pruvost, A; Rossitto, M, 2019)
" We examined whether mother's use of paracetamol, aspirin or ibuprofen in pregnancy is associated with increased risk of cerebral palsy (CP) in the child."3.88Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child. ( Andersen, AN; Andersen, GL; Andersen, PK; Liew, Z; Martinussen, T; Olsen, J; Petersen, TG; Rebordosa, C; Strandberg-Larsen, K; Tollånes, MC; Uldall, P; Wilcox, AJ, 2018)
"Ibuprofen exposure during the first trimester was associated with a decrease in birth weight of 79 grams (95% confidence interval -133 to -25 grams)."3.83Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study. ( Nezvalová-Henriksen, K; Nordeng, H; Spigset, O; Wood, M, 2016)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."3.81Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
" IBU blocked LPS-induced fever but did not block LPS-induced increases in plasma cytokines and corticosterone in the pregnant dam."3.75Effects of prenatal immune activation on hippocampal neurogenesis in the rat. ( Ashdown, H; Boksa, P; Cui, K; Luheshi, GN, 2009)
"We confirm by meconium analysis the results of previous studies that demonstrated that the use of NSAIDs during pregnancy, particularly aspirin, ibuprofen, and naproxen, is high; is grossly underestimated by maternal history; and is significantly associated with PPHN."3.71Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. ( Alano, MA; Konduri, GG; Ngougmna, E; Ostrea, EM, 2001)
" After culture, embryo morphological and developmental parameters were documented using standardized scoring systems at each dosage concentration."2.82Assessment of embryo morphology following perinatal exposure to aspirin, ibuprofen and paracetamol using whole embryo culture system. ( Leung, BW; Leung, TY; Moungmaithong, S; Poon, LC; Sahota, DS; Wang, CC, 2022)
"Ibuprofen is a non-selective cyclooxygenase (COX) inhibitor with analgesic, antipyretic and antiinflammatory activity."2.41[Current opinions on embryotoxic and teratogenic effects of ibuprofen]. ( Bełzek, A; Burdan, F, 2001)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.26)18.2507
2000's5 (26.32)29.6817
2010's10 (52.63)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Moungmaithong, S1
Leung, BW1
Sahota, DS1
Wang, CC1
Leung, TY1
Poon, LC1
Rossitto, M2
Ollivier, M1
Déjardin, S1
Pruvost, A2
Brun, C1
Marchive, C2
Nguyen, AL1
Ghettas, A2
Keime, C1
de Massy, B1
Poulat, F2
Philibert, P2
Boizet-Bonhoure, B2
Rifas-Shiman, SL2
Cardenas, A1
Hivert, MF1
Tiemeier, H1
Bertoldi, AD1
Oken, E1
Balin, PDS1
Jorge, BC1
Leite, ARR1
Borges, CS1
Oba, E1
Silva, EJR1
de Barros, AL1
Horta-Júnior, JAC1
Arena, AC1
Petersen, TG1
Liew, Z1
Andersen, AN1
Andersen, GL1
Andersen, PK1
Martinussen, T1
Olsen, J2
Rebordosa, C2
Tollånes, MC1
Uldall, P1
Wilcox, AJ1
Strandberg-Larsen, K1
Sellem, E1
Badiou, S1
Sutra, T1
Sordillo, JE1
Scirica, CV1
Gillman, MW1
Bunyavanich, S1
Camargo, CA1
Weiss, ST1
Gold, DR1
Litonjua, AA1
Shaheen, SO1
Kristensen, DM2
Mazaud-Guittot, S1
Gaudriault, P1
Lesné, L2
Serrano, T1
Main, KM2
Jégou, B2
Nezvalová-Henriksen, K1
Wood, M1
Spigset, O1
Nordeng, H1
Cui, K1
Ashdown, H1
Luheshi, GN1
Boksa, P1
Hass, U1
Lottrup, G1
Jacobsen, PR1
Desdoits-Lethimonier, C1
Boberg, J1
Petersen, JH1
Toppari, J1
Jensen, TK1
Brunak, S1
Skakkebaek, NE1
Nellemann, C1
Leffers, H1
Vieux, R1
Fresson, J1
Guillemin, F1
Hascoet, JM1
Jensen, MS1
Henriksen, TB1
Thulstrup, AM1
Toft, G1
Sørensen, HT1
Bonde, JP1
Wen, SW1
Yang, T1
Krewski, D1
Yang, Q1
Nimrod, C1
Garner, P1
Fraser, W1
Olatunbosun, O1
Walker, MC1
Takizawa, T1
Ikeda, Y1
Kawahata, M1
Togashi, H1
Yamamoto, M1
Arishima, K1
Masaoka, T1
Cuzzolin, L1
Dal Cerè, M1
Fanos, V1
Alano, MA1
Ngougmna, E1
Ostrea, EM1
Konduri, GG1
Burdan, F1
Bełzek, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Copenhagen Analgesic Study[NCT04369222]600 participants (Anticipated)Observational2020-03-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for ibuprofen and Delayed Effects, Prenatal Exposure

ArticleYear
Assessment of embryo morphology following perinatal exposure to aspirin, ibuprofen and paracetamol using whole embryo culture system.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25

    Topics: Acetaminophen; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Female; Humans; Ibuprofen;

2022
Analgesic use - prevalence, biomonitoring and endocrine and reproductive effects.
    Nature reviews. Endocrinology, 2016, Volume: 12, Issue:7

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Commerce;

2016
NSAID-induced nephrotoxicity from the fetus to the child.
    Drug safety, 2001, Volume: 24, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Ductus Arteriosus, Patent; Female;

2001
[Current opinions on embryotoxic and teratogenic effects of ibuprofen].
    Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2001, Volume: 11, Issue:63

    Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Female; Gastroschisis; Humans;

2001

Other Studies

15 other studies available for ibuprofen and Delayed Effects, Prenatal Exposure

ArticleYear
In utero exposure to acetaminophen and ibuprofen leads to intergenerational accelerated reproductive aging in female mice.
    Communications biology, 2019, Volume: 2

    Topics: Acetaminophen; Aging; Animals; Animals, Newborn; Cell Proliferation; Female; Fertility; Forkhead Box

2019
Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour.
    Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3

    Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Child; Child Behavior; Child Behavior Disorder

2020
Maternal exposure to ibuprofen can affect the programming of the hypothalamus of the male offspring.
    Regulatory toxicology and pharmacology : RTP, 2020, Volume: 111

    Topics: Animals; Brain; Female; Hypothalamus; Ibuprofen; Male; Maternal Exposure; Pregnancy; Prenatal Exposu

2020
Use of paracetamol, ibuprofen or aspirin in pregnancy and risk of cerebral palsy in the child.
    International journal of epidemiology, 2018, 02-01, Volume: 47, Issue:1

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Aspirin; Cerebral Palsy; Cohort Studies; Female; Hum

2018
Intergenerational effects on mouse sperm quality after in utero exposure to acetaminophen and ibuprofen.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:1

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Embryo, M

2019
Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chi

2015
Acetaminophen and childhood asthma: pill-popping at our peril?
    The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Hu

2015
Association of Prenatal Ibuprofen Exposure with Birth Weight and Gestational Age: A Population-Based Sibling Study.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Birth Weight; Child; Female; Gestational Age; Humans

2016
Effects of prenatal immune activation on hippocampal neurogenesis in the rat.
    Schizophrenia research, 2009, Volume: 113, Issue:2-3

    Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroida

2009
Intrauterine exposure to mild analgesics is a risk factor for development of male reproductive disorders in human and rat.
    Human reproduction (Oxford, England), 2011, Volume: 26, Issue:1

    Topics: Acetaminophen; Analgesics; Animals; Aspirin; Cohort Studies; Cryptorchidism; Female; Humans; Ibuprof

2011
Perinatal drug exposure and renal function in very preterm infants.
    Archives of disease in childhood. Fetal and neonatal edition, 2011, Volume: 96, Issue:4

    Topics: Analgesics, Non-Narcotic; Female; Gestational Age; Glomerular Filtration Rate; Humans; Ibuprofen; In

2011
Analgesics during pregnancy and cryptorchidism: additional analyses.
    Epidemiology (Cambridge, Mass.), 2011, Volume: 22, Issue:4

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Aspirin; Cryptorchidism; Cyclooxygenase Inhibitors; Female;

2011
Patterns of pregnancy exposure to prescription FDA C, D and X drugs in a Canadian population.
    Journal of perinatology : official journal of the California Perinatal Association, 2008, Volume: 28, Issue:5

    Topics: Adult; Albuterol; Contraceptives, Oral; Cross-Sectional Studies; Drug Prescriptions; Drug-Related Si

2008
Increased ductal responsiveness to PGE2 after maternal treatment with aspirin and ibuprofen.
    The Journal of veterinary medical science, 1998, Volume: 60, Issue:3

    Topics: Administration, Oral; Animals; Animals, Newborn; Aspirin; Cesarean Section; Dinoprostone; Ductus Art

1998
Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn.
    Pediatrics, 2001, Volume: 107, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bronchodilator Agents; Extracorporeal Membrane Oxy

2001