ibuprofen has been researched along with Costen's Syndrome in 6 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "4 men) with daily or near-daily orofacial pain of at least 3 months' duration and tenderness to palpation of masticatory muscles participated." | 2.68 | A controlled evaluation of ibuprofen and diazepam for chronic orofacial muscle pain. ( Dionne, R; Singer, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alencar, FG | 2 |
| Viana, PG | 1 |
| Zamperini, C | 2 |
| Becker, A | 1 |
| Kerins, CA | 1 |
| Carlson, DS | 1 |
| McIntosh, JE | 1 |
| Bellinger, LL | 1 |
| Venâncio, Rde A | 1 |
| Campbell, K | 1 |
| Singer, E | 1 |
| Dionne, R | 1 |
| Naeije, M | 1 |
| Lobbezoo, F | 1 |
| van Loon, LA | 1 |
| Savalle, WP | 1 |
| van der Zaag, J | 1 |
| Huddleston Slater, JJ | 1 |
| van der Meulen, MJ | 1 |
| Visscher, CM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Prospective Comparison of Medications Used in Trigger Point Injections - Ketorolac, Lidocaine, or Dexamethasone[NCT03028012] | Phase 4 | 10 participants (Actual) | Interventional | 2017-05-02 | Terminated (stopped due to Poor enrollment.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Participants in this study underwent TPIs by the following method. The needle was inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. This was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain, one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Post Injections Up to Three Months
| Intervention | Participants (Count of Participants) |
|---|---|
| Ketorolac | 1 |
| Lidocaine | 0 |
| Dexamethasone | 0 |
The BPI was evaluated on a scale from 0-10. Zero would mean no interference and 10 would be calculated at complete interferences. We used a 7-point questionnaire about pain. All scores were calculated at baseline and three months. (NCT03028012)
Timeframe: Baseline and Three Months
| Intervention | score on a scale (Number) | |||
|---|---|---|---|---|
| Participant Number #3 at Baseline | Participant Number #3 at 3 Months | Participant Number #8 at Baseline | Participant #8 at 3 Months | |
| Ketorolac | 8 | 3 | 5 | 3 |
TPI were treated with a needle inserted into the trigger point with the goal of eliciting a local twitch responses(LTRs). When a LTR was obtained, 0.1mL of randomized drug was injected into that location within the muscle. This was repeated until LTRs disappeared, or 1.0mL had been injected, whichever came first. Such was performed in a similar manner for all affected muscles, up to a maximum of 2mL. Participants self-report their brief pain inventory at each of their injections (up to four subsequent injections) based off of the standardized Numeric Rating pain Scale (NRS). The NRS is nationally recognized numeric scale from zero to ten, with zero being an example of no pain,one to three would demonstrate mild pain, four to six would be moderate pain, seven to nine would be severe pain and a ten would be the worst pain possible. Improvement in BPI was determined if their NRS score went down with each injection(s). (NCT03028012)
Timeframe: Pre-Injection and Three Month Post Injection(s)
| Intervention | score on a scale (Number) | |||
|---|---|---|---|---|
| Participant Number 3 at Baseline | Participant Number 3 at 3 Months | Participant Number 8 at Baseline | Participant Number 8 at 3 Months | |
| Ketorolac | 8 | 3 | 5 | 3 |
1 review available for ibuprofen and Costen's Syndrome
| Article | Year |
|---|---|
[Treatment protocol for craniomandibular dysfunction 2. Treatment].
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Behavior Therapy; Combined Modality Therapy; Cr | 2000 |
3 trials available for ibuprofen and Costen's Syndrome
| Article | Year |
|---|---|
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
Topics: Adolescent; Adult; Aged; Amitriptyline; Analgesics, Non-Narcotic; Clonidine; Double-Blind Method; Fa | 2014 |
Different substances and dry-needling injections in patients with myofascial pain and headaches.
Topics: Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anesthetics, Local; Anti-Inflammatory Agents; Ant | 2008 |
A controlled evaluation of ibuprofen and diazepam for chronic orofacial muscle pain.
Topics: Adult; Analysis of Variance; Anti-Anxiety Agents; Anti-Inflammatory Agents, Non-Steroidal; beta-Endo | 1997 |
2 other studies available for ibuprofen and Costen's Syndrome
| Article | Year |
|---|---|
Meal pattern changes associated with temporomandibular joint inflammation/pain in rats; analgesic effects.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Eating; Edema; Estradiol; | 2003 |
Tinnitus and vertigo.
Topics: Aspirin; Humans; Ibuprofen; Temporomandibular Joint Dysfunction Syndrome; Tinnitus; Vertigo | 1993 |