Page last updated: 2024-10-28

ibuprofen and Coronary Disease

ibuprofen has been researched along with Coronary Disease in 26 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.

Research Excerpts

ExcerptRelevanceReference
"In parallel with experimental research into methods for salvage of ischemic myocardium after acute myocardial infarction (AMI) over the last decade, there has been a growing interest in prostaglandins (PG) and their inhibition by aspirin-like drugs or nonsteroidal anti-inflammatory drugs (NSAID)."4.76Prostaglandin inhibition and myocardial infarct size. ( Becker, LC; Jugdutt, BI, 1981)
"To estimate the net cardiovascular (CV) (coronary heart disease, stroke, congestive heart failure), and gastrointestinal (GI) (peptic ulcer complications) risk-benefit public health impact of the use of celecoxib compared to non-selective NSAIDs in the arthritis population."3.74Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level. ( Castellsague, J; Maguire, A; Perez-Gutthann, S; Varas-Lorenzo, C, 2007)
"Non-aspirin, non-steroidal anti-inflammatory drugs (NANSAIDs) have complex effects that could either prevent or promote coronary heart disease."3.71Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease: an observational cohort study. ( Daugherty, JR; Griffin, MR; Hall, K; Ray, WA; Stein, CM, 2002)
"Arrhythmias were produced by ouabain (2."3.67Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain. ( Ferrier, GR; Karmazyn, M; Moffat, MP, 1985)
"Naproxen was associated with an OR of 0."1.32Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population. ( García Rodríguez, LA; González-Pérez, A; Maguire, A; Varas-Lorenzo, C, 2004)
"Necrosis was minimal, averaging only 2."1.27Impaired function of salvaged myocardium: two-dimensional echocardiographic quantification of regional wall thickening in the open-chest dog. ( Becker, LC; Blumenthal, DS; Bulkley, BH; Hutchins, GM; Weisfeldt, ML; Weiss, JL, 1983)
"Ibuprofen was the most effective, producing an average recovery of 70% (P less than 0."1.27Contribution of prostaglandins to reperfusion-induced ventricular failure in isolated rat hearts. ( Karmazyn, M, 1986)
"Adenosine was extracted at rest, but during ischemia there was a significant release of its metabolite hypoxanthine, indicating increased myocardial breakdown of high-energy adenine nucleotides."1.27Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation. ( Berglund, B; Edlund, A; Kaijser, L; Nowak, J; Patrono, C; Sollevi, A; van Dorne, D; Wennmalm, A, 1985)
"In 67 dogs with a 60-80% coronary stenosis produced by an external constricting plastic ring, blood flow measured with an electromagnetic flowmeter showed cyclical flow reductions of varying magnitude and duration, and then an abrupt return to control flow."1.26Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation? ( Folts, JD; Gallagher, K; Rowe, GG, 1982)
"Flurbiprofen was given at 0."1.26Effects of flurbiprofen on myocardial cell damage in acute myocardial ischemia. ( Carrow, BA; Lefer, AM; Smith, EF, 1980)
"Ibuprofen was administered intravenously at a dose of 12."1.26Beneficial effects of ibuprofen in acute myocardial ischemia. ( Lefer, AM; Polansky, EW, 1979)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199019 (73.08)18.7374
1990's1 (3.85)18.2507
2000's5 (19.23)29.6817
2010's1 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhala, N1
Emberson, J1
Merhi, A1
Abramson, S1
Arber, N1
Baron, JA1
Bombardier, C1
Cannon, C1
Farkouh, ME1
FitzGerald, GA1
Goss, P1
Halls, H1
Hawk, E1
Hawkey, C1
Hennekens, C1
Hochberg, M1
Holland, LE1
Kearney, PM1
Laine, L1
Lanas, A1
Lance, P1
Laupacis, A1
Oates, J1
Patrono, C2
Schnitzer, TJ1
Solomon, S1
Tugwell, P1
Wilson, K1
Wittes, J1
Baigent, C1
Ray, WA2
Stein, CM2
Daugherty, JR2
Hall, K2
Arbogast, PG1
Griffin, MR2
García Rodríguez, LA1
Varas-Lorenzo, C2
Maguire, A2
González-Pérez, A1
Castellsague, J1
Perez-Gutthann, S1
Marijon, E1
Fressonnet, R1
Haggui, A1
Mousseaux, E1
Redheuil, A1
Aiken, JW1
Shebuski, RJ1
Miller, OV1
Gorman, RR1
Blumenthal, DS1
Becker, LC4
Bulkley, BH3
Hutchins, GM3
Weisfeldt, ML1
Weiss, JL1
Jugdutt, BI2
Folts, JD1
Gallagher, K1
Rowe, GG1
Kirlin, PC1
Romson, JL3
Pitt, B1
Abrams, GD1
Schork, MA1
Lucchesi, BR4
Darsee, JR1
Kloner, RA1
Smith, EF1
Carrow, BA1
Lefer, AM2
Haack, DW2
Bush, LR1
Chen, CY1
Chen, CS1
Polansky, EW1
Karmazyn, M2
Crawford, MH1
Grover, FL1
Kolb, WP1
McMahan, CA1
O'Rourke, RA1
McManus, LM1
Pinckard, RN1
Michael, LH1
Hunt, JR1
Lewis, RM1
Entman, ML1
Reimer, KA1
Jennings, RB1
Cobb, FR1
Murdock, RH1
Greenfield, JC1
Schwartz, RP1
Bailey, KR1
Edlund, A1
Berglund, B1
van Dorne, D1
Kaijser, L1
Nowak, J1
Sollevi, A1
Wennmalm, A1
Moffat, MP1
Ferrier, GR1
Werns, SW1
Shea, MJ1
Grover, GJ1
Weiss, HR1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
WilL LOWer Dose Aspirin be More Effective Following ACS? (WILLOW-ACS)[NCT02741817]Phase 420 participants (Actual)Interventional2016-06-26Completed
Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators[NCT03664466]0 participants (Actual)Interventional2021-04-29Withdrawn (stopped due to Inadequate funding)
Analgesic Efficacy of Preoperative Oral Administration of Dexketoprofen Trometamol in Third Molar Surgery, Compared to Postoperative Administration[NCT02380001]Phase 460 participants (Actual)Interventional2015-01-31Completed
Treatment Efficacy of 'Shinbaro Capsule' in the Treatment of Hand Osteoarthritis: Randomized, Double-blinded, Placebo-controlled, Multicenter Investigator Initiated Trial.[NCT01910116]Phase 2/Phase 3220 participants (Actual)Interventional2013-09-30Completed
Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652]502 participants (Actual)Observational [Patient Registry]2015-01-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

AUSCAN Function Change at 12 Weeks From Baseline

"Change in AUSCAN function score at 12 weeks from baseline = Function score at 12 weeks (0-100)- Function score at baseline (0-100). AUSCAN Function score scale ranges from 0 (no functional limitation) to 100 (worst possible functional limitation).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 12 weeks

Interventionunits on a scale (Median)
Shinbaro-11
Placebo-2.9

AUSCAN Function Change at 16 Weeks From Baseline

"Change in AUSCAN function score at 16 weeks from baseline = Function score at 16 weeks (0-100)- Function score at baseline (0-100). AUSCAN Function score scale ranges from 0 (no functional limitation) to 100 (worst possible functional limitation).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

Interventionunits on a scale (Median)
Shinbaro-9.9
Placebo-4.8

AUSCAN Function Change at 4 Weeks From Baseline

"Change in AUSCAN function score at 4 weeks from baseline = Function score at 4 weeks (0-100)- Function score at baseline (0-100). AUSCAN Function score scale ranges from 0 (no functional limitation) to 100 (worst possible functional limitation).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Basline and 4 weeks

Interventionunits on a scale (Median)
Shinbaro-6.8
Placebo-3.7

AUSCAN Function Change at 8 Weeks From Baseline

"Change in AUSCAN function score at 8 weeks from baseline = Function score at 8 weeks (0-100)- Function score at baseline (0-100). AUSCAN Function score scale ranges from 0 (no functional limitation) to 100 (worst possible functional limitation).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 8 weeks

Interventionunits on a scale (Median)
Shinbaro-9.7
Placebo-4.8

AUSCAN Pain Change at 4 Weeks From Baseline

"Change in AUSCAN pain score at 4 weeks from baseline = Pain at 4 weeks (0-100) - Pain at baseline (0-100).~AUSCAN Pain scale ranges from 0 (no pain) to 100 (worst possible pain).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 4 weeks

Interventionunits on a scale (Median)
Shinbaro-9.0
Placebo-2.2

AUSCAN Pain Score at 12 Weeks From Baseline

"Change in AUSCAN pain score at 12 weeks from baseline = Pain at 12 weeks (0-100)- Pain at baseline (0-100). AUSCAN Pain scale ranges from 0 (no pain) to 100 (worst possible pain).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline, 12 weeks

Interventionunits on a scale (Median)
Shinbaro-14.6
Placebo-8.0

AUSCAN Pain Score at 16 Weeks From Baseline

"Change in AUSCAN pain score at 16 weeks from baseline = Pain at 16 weeks (0-100)- Pain at baseline (0-100). AUSCAN Pain scale ranges from 0 (no pain) to 100 (worst possible pain).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

Interventionunits on a scale (Median)
Shinbaro-15.6
Placebo-4.4

AUSCAN Pain Score at 8 Weeks From Baseline

"Change in AUSCAN pain score at 8 weeks from baseline = Pain at 8 weeks (0-100)- Pain at baseline (0-100). AUSCAN Pain scale ranges from 0 (no pain) to 100 (worst possible pain).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline, 8 weeks

Interventionunits on a scale (Median)
Shinbaro-13.4
Placebo-2.2

AUSCAN Stiffness at 12 Weeks Change From Baseline

"Change in AUSCAN stiffness score at 12 weeks from baseline = Stiffness at 12 weeks (0-100)- Stiffness at baseline (0-100). AUSCAN Stiffness scale ranges from 0 (no stiffness) to 100 (worst possible stiffness).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Basline and 12 weeks

Interventionunits on a scale (Median)
Shinbaro-14.0
Placebo-11.0

AUSCAN Stiffness at 16 Weeks Change From Baseline

"Change in AUSCAN stiffness score at 16 weeks from baseline = Stiffness at 16 weeks (0-100)- Stiffness at baseline (0-100). AUSCAN Stiffness scale ranges from 0 (no stiffness) to 100 (worst possible stiffness).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline, 16 weeks

Interventionunits on a scale (Median)
Shinbaro-10.0
Placebo-8.0

AUSCAN Stiffness at 4 Weeks Change From Baseline

"Change in AUSCAN stiffness score at 4 weeks from baseline = Stiffness at 4 weeks (0-100)- Stiffness at baseline (0-100). AUSCAN Stiffness scale ranges from 0 (no stiffness) to 100 (worst possible stiffness).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 4 weeks

Interventionunits on a scale (Median)
Shinbaro-9.0
Placebo-6.0

AUSCAN Stiffness at 8 Weeks Change From Baseline

"Change in AUSCAN stiffness score at 8 weeks from baseline = Stiffness at 8 weeks (0-100)- Stiffness at baseline (0-100). AUSCAN Stiffness scale ranges from 0 (no stiffness) to 100 (worst possible stiffness).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: baseline and 8 weeks

Interventionunits on a scale (Median)
Shinbaro-12.0
Placebo-6

Number of OMERACT-OARSI Responder

Number of patients who met OMERACT-OARSI criteria = significant clinical improvement in osteoarthritis symptom after treatment (NCT01910116)
Timeframe: Baselie and 16 weeks

Interventionparticipants (Number)
Shinbaro55
Placebo40

Patient Global Assessment, Change From Baseline

"Change in Patient global assessment (PGA) at 12 weeks from baseline = PGA at 12 weeks (0-100)- PGA score at baseline (0-100). GPA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 12 weeks

Interventionunits on a scale (Median)
Shinbaro-11.0
Placebo-6.0

Patient Global Assessment, Change From Baseline

"Change in Patient global assessment (PGA) at 16 weeks from baseline = PGA at 16 weeks (0-100)- PGA score at baseline (0-100). PGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

Interventionunits on a scale (Median)
Shinbaro-10.0
Placebo-8.5

Patient Global Assessment, Change From Baseline

"Change in Patient global assessment (PGA) at 4 weeks from baseline = PGA at 4 weeks (0-100)- PGA score at baseline (0-100). PGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 4 weeks

Interventionunits on a scale (Median)
Shinbaro-9.0
Placebo-3.0

Patient Global Assessment, Change From Baseline

"Change in Patient global assessment (PGA) at 8 weeks from baseline = PGA at 8 weeks (0-100)- PGA score at baseline (0-100). PGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 8 weeks

Interventionunits on a scale (Median)
Shinbaro-10.0
Placebo-6.0

Physician Global Assessment, Change From Baseline

"Change in Physician global assessment (PhGA) at 12 weeks from baseline = PhGA at 12 weeks (0-100)- PhGA score at baseline (0-100). PhGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 12 weeks

Interventionunits on a scale (Median)
Shinbaro-19.0
Placebo-13

Physician Global Assessment, Change From Baseline

"Change in Physician global assessment (PhGA) at 16 weeks from baseline = PhGA at 16 weeks (0-100)- PhGA score at baseline (0-100). PhGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

Interventionunits on a scale (Median)
Shinbaro-12
Placebo-6.5

Physician Global Assessment, Change From Baseline

"Change in Physician global assessment (PhGA) at 4 weeks from baseline = PhGA at 4 weeks (0-100)- PhGA score at baseline (0-100). GPA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: baseline and 4 weeks

Interventionunits on a scale (Median)
Shinbaro-12
Placebo-7.0

Physician Global Assessment, Change From Baseline

"Change in Physician global assessment (PhGA) at 8 weeks from baseline = PhGA at 8 weeks (0-100)- PhGA score at baseline (0-100). PhGA scale ranges from 0 (excellent condition) to 100 (worst possible worse possible condition).~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 8 weeks

Interventionunits on a scale (Median)
Shinbaro-16.0
Placebo-11.5

Swollen Joint Count, Change From Baseline

"Change in Swollen joint count (SJC) at 12 weeks from baseline = SJC at 12 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 12 weeks

InterventionJoints (Median)
Shinbaro0
Placebo0

Swollen Joint Count, Change From Baseline

"Change in Swollen joint count (SJC) at 16 weeks from baseline = SJC at 16 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

InterventionJoints (Median)
Shinbaro0
Placebo0

Swollen Joint Count, Change From Baseline

"Change in Swollen joint count (SJC) at 4 weeks from baseline = SJC at 4 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 4 weeks

InterventionJoints (Median)
Shinbaro0
Placebo0

Swollen Joint Count, Change From Baseline

"Change in Swollen joint count (SJC) at 8 weeks from baseline = SJC at 8 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 8 weeks

InterventionJoints (Median)
Shinbaro0
Placebo0

Tender Joint Count, Change From Baseline

"Change in Tender joint count (TJC) at 12 weeks from baseline = TJC at 12 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 12 weeks

Interventionjoints (Median)
Shinbaro-2.0
Placebo-1.0

Tender Joint Count, Change From Baseline

"Change in Tender joint count (TJC) at 16 weeks from baseline = TJC at 16 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 16 weeks

Interventionjoints (Median)
Shinbaro-2.0
Placebo-1.0

Tender Joint Count, Change From Baseline

"Change in Tender joint count (TJC) at 4 weeks from baseline = TJC at 4 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 4 weeks

Interventionjoints (Median)
Shinbaro-1
Placebo0

Tender Joint Count, Change From Baseline

"Change in Tender joint count (TJC) at 8 weeks from baseline = TJC at 8 weeks - TJC at baseline..~Negative value means improvement from baseline~Positive value means deterioration from baseline" (NCT01910116)
Timeframe: Baseline and 8 weeks

InterventionJoints (Median)
Shinbaro-1.0
Placebo-1.0

Acetaminophen Rescue

yes = AAP rescue use, no = no AAP rescue use (NCT01910116)
Timeframe: 12 weeks and 16 weeks

,
Interventionparticipants (Number)
yesno
Placebo2104
Shinbaro4105

Acetaminophen Rescue

yes = AAP rescue use, no = no AAP rescue use (NCT01910116)
Timeframe: 4 weeks and 8 weeks

,
Interventionparticipants (Number)
yesno
Placebo799
Shinbaro1099

Acetaminophen Rescue

yes = AAP rescue use, no = no AAP rescue use (NCT01910116)
Timeframe: 8 weeks and 12 weeks

,
Interventionparticipants (Number)
yesno
Placebo4102
Shinbaro4105

Acetaminophen Rescue

yes = AAP rescue use, no = no AAP rescue use (NCT01910116)
Timeframe: Baseline 4 weeks

,
Interventionparticipants (Number)
yesno
Placebo4102
Shinbaro7102

Number of OMERACT-OARSI Responder

Number of patients who met OMERACT-OARSI criteria = significant clinical improvement in osteoarthritis symptom after treatment (NCT01910116)
Timeframe: Baseline and 12 weeks

,
Interventionparticipants (Number)
respondernonresponder
Placebo4363
Shinbaro6247

Number of OMERACT-OARSI Responder

Number of patients who met OMERACT-OARSI criteria = significant clinical improvement in osteoarthritis symptom after treatment (NCT01910116)
Timeframe: Baseline and 8 weeks

,
Interventionparticipants (Number)
respondernonresponder
Placebo3868
Shinbaro5653

Number of OMERACT-OARSI Responder

Outcome Measures in Rheumatology-Osteoarthritis Research Society International (OMERACT-OARSI) Number of patients who met OMERACT-OARSI criteria = significant clinical improvement in osteoarthritis symptom after treatment (NCT01910116)
Timeframe: Baseline and 4 weeks

,
Interventionparticipants (Number)
ResponderNonresponder
Placebo3274
Shinbaro4861

Reviews

2 reviews available for ibuprofen and Coronary Disease

ArticleYear
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials.
    Lancet (London, England), 2013, Aug-31, Volume: 382, Issue:9894

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Vessels; Coronary Disease; Cyclooxygenase 2 Inhibitor

2013
Prostaglandin inhibition and myocardial infarct size.
    Clinical cardiology, 1981, Volume: 4, Issue:3

    Topics: Acute Disease; Animals; Aspirin; Coronary Disease; Humans; Ibuprofen; Indomethacin; Models, Biologic

1981

Other Studies

24 other studies available for ibuprofen and Coronary Disease

ArticleYear
COX-2 selective non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease.
    Lancet (London, England), 2002, Oct-05, Volume: 360, Issue:9339

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Coronary Disease; Cyclo

2002
Nonsteroidal antiinflammatory drugs and the risk of myocardial infarction in the general population.
    Circulation, 2004, Jun-22, Volume: 109, Issue:24

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cardiotonic Agents; Case-

2004
Quantitative assessment of the gastrointestinal and cardiovascular risk-benefit of celecoxib compared to individual NSAIDs at the population level.
    Pharmacoepidemiology and drug safety, 2007, Volume: 16, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cardiovascular D

2007
Spontaneous coronary dissection of the left main stem after intense physical activity--regression under conservative strategy.
    International journal of cardiology, 2008, Aug-01, Volume: 128, Issue:1

    Topics: Angioplasty, Balloon, Coronary; Coronary Disease; Cyclooxygenase Inhibitors; Drug-Eluting Stents; Ec

2008
Endogenous prostacyclin contributes to the efficacy of a thromboxane synthetase inhibitor for preventing coronary artery thrombosis.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:2

    Topics: Acrylates; Animals; Aspirin; Blood Platelets; Coronary Disease; Cyclic AMP; Cyclooxygenase Inhibitor

1981
Impaired function of salvaged myocardium: two-dimensional echocardiographic quantification of regional wall thickening in the open-chest dog.
    Circulation, 1983, Volume: 67, Issue:1

    Topics: Animals; Coronary Circulation; Coronary Disease; Dipyridamole; Dogs; Echocardiography; Epoprostenol;

1983
Blood flow reductions in stenosed canine coronary arteries: vasospasm or platelet aggregation?
    Circulation, 1982, Volume: 65, Issue:2

    Topics: Animals; Aspirin; Constriction, Pathologic; Coronary Angiography; Coronary Circulation; Coronary Dis

1982
Ibuprofen-mediated infarct size reduction: effects on regional myocardial function in canine myocardial infarction in canine myocardial infarction.
    The American journal of cardiology, 1982, Volume: 50, Issue:4

    Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Coronary Disease; Dogs; Heart Rate; Ibuprofen;

1982
Dependency of location of salvageable myocardium on type of intervention.
    The American journal of cardiology, 1981, Volume: 48, Issue:4

    Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Female; Flurbiprofen; Glycine; Heart; Ibuprof

1981
Salvage of ischemic myocardium by ibuprofen during infarction in the conscious dog.
    The American journal of cardiology, 1980, Volume: 46, Issue:1

    Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Disease; Dogs; Electrocardiography; Heart Ra

1980
Effects of flurbiprofen on myocardial cell damage in acute myocardial ischemia.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 28, Issue:3

    Topics: Acute Disease; Animals; Blood Pressure; Cats; Cell Membrane; Coronary Disease; Creatine Kinase; Elec

1980
Electrical induction of coronary artery thrombosis in the ambulatory canine: a model for in vivo evaluation of anti-thrombotic agents.
    Thrombosis research, 1980, Mar-15, Volume: 17, Issue:6

    Topics: Animals; Anticoagulants; Collagen; Coronary Disease; Coronary Vessels; Disease Models, Animal; Dogs;

1980
The beneficial effects of oral ibuprofen on coronary artery thrombosis and myocardial ischemia in the conscious dog.
    The Journal of pharmacology and experimental therapeutics, 1980, Volume: 215, Issue:1

    Topics: Administration, Oral; Animals; Arteries; Coronary Disease; Coronary Vessels; Dogs; Drug Evaluation;

1980
Stereoselective disposition of ibuprofen in patients with compromised renal haemodynamics.
    British journal of clinical pharmacology, 1995, Volume: 40, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Coronary Disease; Diabetes Mellitus; Female; Heart Fa

1995
Non-steroidal anti-inflammatory drugs and risk of serious coronary heart disease: an observational cohort study.
    Lancet (London, England), 2002, Jan-12, Volume: 359, Issue:9301

    Topics: Age Distribution; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bias; C

2002
Beneficial effects of ibuprofen in acute myocardial ischemia.
    Cardiology, 1979, Volume: 64, Issue:5

    Topics: Acute Disease; Animals; Cathepsins; Cats; Coronary Disease; Creatine Kinase; Drug Evaluation, Precli

1979
Contribution of prostaglandins to reperfusion-induced ventricular failure in isolated rat hearts.
    The American journal of physiology, 1986, Volume: 251, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aspirin; Coronary Circulation; Coronary Disease; Cyclooxygena

1986
Complement and neutrophil activation in the pathogenesis of ischemic myocardial injury.
    Circulation, 1988, Volume: 78, Issue:6

    Topics: Animals; Complement Activation; Complement System Proteins; Coronary Disease; Creatine Kinase; Elapi

1988
Myocardial ischemia: platelet and thromboxane concentrations in cardiac lymph and the effects of ibuprofen and prostacyclin.
    Circulation research, 1986, Volume: 59, Issue:1

    Topics: Animals; Blood Platelets; Coronary Disease; Dogs; Epoprostenol; Ibuprofen; Lymph; Platelet Aggregati

1986
Animal models for protecting ischemic myocardium: results of the NHLBI Cooperative Study. Comparison of unconscious and conscious dog models.
    Circulation research, 1985, Volume: 56, Issue:5

    Topics: Anesthesia; Animal Testing Alternatives; Animals; Arterial Occlusive Diseases; Coronary Circulation;

1985
Coronary flow regulation in patients with ischemic heart disease: release of purines and prostacyclin and the effect of inhibitors of prostaglandin formation.
    Circulation, 1985, Volume: 71, Issue:6

    Topics: Adenosine; Adult; Aged; Coronary Circulation; Coronary Disease; Epoprostenol; Humans; Ibuprofen; Ind

1985
Prostaglandin involvement in hypersensitivity of ischemic hearts to arrhythmogenic influence of ouabain.
    The American journal of physiology, 1985, Volume: 249, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Arachidonic Acid; Arachidonic Acids; Arrhythmias, Cardiac; As

1985
Free radicals in ischemic myocardial injury.
    Journal of free radicals in biology & medicine, 1985, Volume: 1, Issue:2

    Topics: Animals; Arachidonate Lipoxygenases; Catalase; Coronary Disease; Dogs; Free Radicals; Ibuprofen; Inf

1985
Effect of ibuprofen and indomethacin on the O2 supply/consumption balance in ischemic rabbit myocardium.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1985, Volume: 180, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Coronary Circulation; Coronary Disease; Heart; Ibuprofen; Indomet

1985