ibuprofen and Complications, Pregnancy studies

Research Excerpts

Excerpt	Relevance	Reference
"To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome."	7.79	Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. ( Nezvalová-Henriksen, K; Nordeng, H; Spigset, O, 2013)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."	7.75	Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Examine associations of acetaminophen and ibuprofen use during pregnancy and infancy with executive function and behaviour problems in children."	3.96	Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour. ( Bertoldi, AD; Cardenas, A; Hivert, MF; Oken, E; Rifas-Shiman, SL; Tiemeier, H, 2020)
" For asthma, albuterol was reported most frequently (77."	3.88	Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. ( Ansari, S; Bandoli, G; Chambers, CD; Hulugalle, A; Kuo, GM; Palmsten, K; Xu, R, 2018)
"To investigate the individual effects of ibuprofen, diclofenac, naproxen, and piroxicam on pregnancy outcome."	3.79	Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. ( Nezvalová-Henriksen, K; Nordeng, H; Spigset, O, 2013)
"Empirical evidence is needed to guide adequate postpartum pain relief of methadone and buprenorphine stabilized patients."	3.75	Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. ( Dahne, J; Johnson, R; Jones, HE; Lemoine, L; Milio, L; O'Grady, K; Ordean, A; Selby, P, 2009)
"Previous studies of gastroschisis have suggested that risk is increased for maternal use of vasoactive over-the-counter medications, including specific analgesics and decongestants."	1.31	Maternal medication use and risks of gastroschisis and small intestinal atresia. ( Mitchell, AA; Sheehan, JE; Werler, MM, 2002)

Research

Studies (15)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Fetal Outcome 1 - Incidence of Early Preterm Delivery (<34 Weeks)

Fetal Outcome 2 - Incidence of Actual Birth Weight <2500g

Fetal Outcome 3 - Incidence of Actual Birth Weight <1500g

Fetal Outcome 4 - Incidence of Fetal Loss

Fetal Outcome 5 - Incidence of Spontaneous Abortion

Fetal Outcome 6 - Incidence of All Stillbirth

Fetal Outcome 7 - Incidence of Medical Termination of Pregnancy

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (13.33)	18.7374
1990's	1 (6.67)	18.2507
2000's	4 (26.67)	29.6817
2010's	7 (46.67)	24.3611
2020's	1 (6.67)	2.80

Authors	Studies
Rifas-Shiman, SL	1
Cardenas, A	1
Hivert, MF	1
Tiemeier, H	1
Bertoldi, AD	1
Oken, E	1
Palmsten, K	1
Hulugalle, A	1
Bandoli, G	1
Kuo, GM	1
Ansari, S	1
Xu, R	1
Chambers, CD	1
Nezvalová-Henriksen, K	1
Spigset, O	1
Nordeng, H	1
Damase-Michel, C	1
Hurault-Delarue, C	1
Gaul, C	1
Gupta, D	1
Christensen, C	1
Soskin, V	1
Schmidt, JJ	1
Ramazan, L	1
Bockemeyer, C	1
Günter, HH	1
Martens-Lobenhoffer, J	1
Ganzenmüller, T	1
Bode-Böger, SM	1
Kielstein, JT	1
Hultzsch, S	1
Schaefer, C	1
Jones, HE	1
O'Grady, K	1
Dahne, J	1
Johnson, R	1
Lemoine, L	1
Milio, L	1
Ordean, A	1
Selby, P	1
McGlennan, A	1
Esler, M	1
Stocks, G	1
Pandit, V	1
Alijotas-Reig, J	1
Suy-Franch, A	1
Casellas-Caro, M	1
Vilardell-Tarres, M	1
Cabero-Roura, L	1
Werler, MM	1
Sheehan, JE	1
Mitchell, AA	1
Huskisson, EC	1
Milazzo, S	1
Kuhn, DC	1
Walenga, RW	1
Stuart, MJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Aspirin Supplementation for Pregnancy Indicated Risk Reduction In Nulliparas (ASPIRIN)[NCT02409680]		11,976 participants (Actual)	Interventional	2016-03-23	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	Participants (Count of Participants)
Intervention Arm	189
Placebo Arm	230

Intervention	Participants (Count of Participants)
Intervention Arm	1078
Placebo Arm	1153

Intervention	Participants (Count of Participants)
Intervention Arm	78
Placebo Arm	101

Intervention	Participants (Count of Participants)
Intervention Arm	303
Placebo Arm	353

Intervention	Participants (Count of Participants)
Intervention Arm	134
Placebo Arm	152

Intervention	Participants (Count of Participants)
Intervention Arm	141
Placebo Arm	166

- Incidence of Medical Termination of Pregnancy (NCT02409680)
Timeframe: At delivery

Incidence of Hypertensive Disorders of Pregnancy

Intervention	Participants (Count of Participants)
Intervention Arm	42
Placebo Arm	30

- Hypertensive disorders of pregnancy is defined by the characterization of evidence of a hypertensive disorder, including either preeclampsia or eclampsia occurring during the pregnancy. (NCT02409680)
Timeframe: Evidence of hypertensive disorder during the pregnancy (prior to delivery/birth)

Incidence of Perinatal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	352
Placebo Arm	325

- Incidence of Perinatal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Incidence of Preterm Birth

Intervention	Participants (Count of Participants)
Intervention Arm	264
Placebo Arm	309

The primary outcome of this study is incidence of preterm birth, which will be defined as delivery at or after 20 0/7 weeks and prior to 37 0/7 weeks. This will be determined based on actual date of delivery in comparison to the projected estimated due date (EDD), independent of whether or not the preterm delivery is indicated or spontaneous. (NCT02409680)
Timeframe: At delivery

Incidence of Small for Gestational Age (SGA)

Intervention	Participants (Count of Participants)
Intervention Arm	668
Placebo Arm	754

- Small for gestational age (SGA) as defined by the INTERGROWTH-21st standard (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 1 - Incidence of Vaginal Bleeding

Intervention	Participants (Count of Participants)
Intervention Arm	1506
Placebo Arm	1564

- Vaginal bleeding (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 2 - Incidence of Antepartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	214
Placebo Arm	246

- Antepartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 3 - Incidence of Postpartum Hemorrhage

Intervention	Participants (Count of Participants)
Intervention Arm	26
Placebo Arm	25

- Postpartum hemorrhage (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 4 - Incidence of Maternal Mortality

Intervention	Participants (Count of Participants)
Intervention Arm	54
Placebo Arm	43

- Incidence of Maternal Mortality (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 5 - Incidence of Late Abortion

Intervention	Participants (Count of Participants)
Intervention Arm	9
Placebo Arm	12

- Incidence of Late Abortion (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Maternal Outcome 6 - Change in Maternal Hemoglobin

Intervention	Participants (Count of Participants)
Intervention Arm	23
Placebo Arm	30

Hemoglobin < 7.0 gm/dl at 26-30 weeks gestation or a drop of 3.5+ gm/dl from screening to 26-30 weeks gestation (NCT02409680)
Timeframe: At enrollment, 4 weeks post enrollment, and 26-30 weeks GA.

Maternal Outcome 7 - Incidence of Preterm, Preeclampsia

Intervention	Participants (Count of Participants)
Intervention Arm	290
Placebo Arm	333

Early preterm delivery (<34 weeks) and hypertensive disorders (i.e.: preeclampsia) (NCT02409680)
Timeframe: At delivery or at Day 42 after delivery

Article	Year
[Analgesic drugs during pregnancy]. Schmerz (Berlin, Germany), 2016, Volume: 30, Issue:6 Topics: Abnormalities, Drug-Induced; Acetaminophen; Acute Pain; Analgesics; Analgesics, Opioid; Anticonvulsa	2016
Antiinflammatory drugs. Seminars in arthritis and rheumatism, 1977, Volume: 7, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Chi	1977

Article	Year
Associations of prenatal or infant exposure to acetaminophen or ibuprofen with mid-childhood executive function and behaviour. Paediatric and perinatal epidemiology, 2020, Volume: 34, Issue:3 Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Child; Child Behavior; Child Behavior Disorder	2020
Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. Paediatric and perinatal epidemiology, 2018, Volume: 32, Issue:1 Topics: Adult; Albuterol; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; Et	2018
Effects of ibuprofen, diclofenac, naproxen, and piroxicam on the course of pregnancy and pregnancy outcome: a prospective cohort study. BJOG : an international journal of obstetrics and gynaecology, 2013, Volume: 120, Issue:8 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Diclofenac; Female; Humans; Ibuprofe	2013
Ibuprofen does not seem to increase global malformation risk but NSAID use in late pregnancy remains a concern. Evidence-based medicine, 2014, Volume: 19, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Female; Humans; Ibuprofen; Naproxen; Piroxicam;	2014
[Aspirin for migraine in pregnancy. This recommendation seems questionable]. MMW Fortschritte der Medizin, 2013, Nov-07, Volume: 155, Issue:19 Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Contraindications; Female; Humans; Ibuprofen; Infa	2013
Marked variability in peri-partum anesthetic management of patients on buprenorphine maintenance therapy (BMT): can there be an underlying acute opioid induced hyperalgesia precipitated by neuraxial opioids in BMT patients? Middle East journal of anaesthesiology, 2013, Volume: 22, Issue:3 Topics: Acetaminophen; Adolescent; Adult; Analgesia, Obstetrical; Analgesics, Opioid; Buprenorphine; Cesarea	2013
Acute interstitial nephritis due to flecainide therapy in the 38(th) week of pregnancy. BMC nephrology, 2016, Mar-15, Volume: 17 Topics: Acute Disease; Acute Kidney Injury; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal;	2016
Management of acute postpartum pain in patients maintained on methadone or buprenorphine during pregnancy. The American journal of drug and alcohol abuse, 2009, Volume: 35, Issue:3 Topics: Acute Disease; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Buprenorphine; Controlled Clinic	2009
PFA-100 and regional analgesia in a parturient after ibuprofen overdose. British journal of anaesthesia, 2004, Volume: 92, Issue:5 Topics: Adult; Analgesia, Epidural; Analgesia, Obstetrical; Analgesics, Non-Narcotic; Contraindications; Dru	2004
Recurrent Kikuchi-Fujimoto necrotizing lymphadenitis during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 2008, Volume: 140, Issue:1 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Histiocytic Necrotizing Lymphadenitis; Human	2008
Maternal medication use and risks of gastroschisis and small intestinal atresia. American journal of epidemiology, 2002, Jan-01, Volume: 155, Issue:1 Topics: Acetaminophen; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Aspirin; Canada; Ephedrine; Fema	2002
The treatment of rheumatoid arthritis. Australian family physician, 1977, Volume: 6, Issue:8 Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Child; Chloroquine; Female; Gold; Humans; Hydroxychl	1977
A prostacyclin analogue crosses the in vitro perfused human placenta and improves transfer in some pathologic states. American journal of perinatology, 1991, Volume: 8, Issue:3 Topics: Antipyrine; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Hypertension; Ibuprofen; In Vit	1991

ibuprofen and Complications, Pregnancy