ibuprofen has been researched along with Colorectal Cancer in 20 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 9.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "With 13 years of follow-up, the authors prospectively evaluated the association between aspirin and ibuprofen use and incident distal adenoma (1221 cases), recurrent adenoma (862 cases), and incident colorectal cancer (CRC; 2826 cases) among men and women in the population-based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial." | 8.02 | Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial. ( Barry, KH; Berndt, SI; Chudy-Onwugaje, K; Huang, WY; Johnson, CC; Katki, HA; Purdue, MP; Su, LJ; Wang, L, 2021) |
| " Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers." | 7.81 | Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome. ( Ahnen, DJ; Ait Ouakrim, D; Baron, JA; Buchanan, DD; Casey, G; Chau, R; Clendenning, M; Dashti, SG; Gallinger, S; Giles, GG; Haile, RW; Hopper, JL; Jenkins, MA; Le Marchand, L; Leggett, B; Lindor, NM; Macrae, FA; Newcomb, PA; Potter, JD; Rosty, C; Thibodeau, SN; Win, AK; Winship, IM; Young, JP, 2015) |
| "To determine whether the nonselective and relatively inexpensive nonsteroidal anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might improve mortality in a mouse model." | 7.73 | Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. ( Albert, A; Chang, AJ; Liu, TC; Sangha, S; Wolfe, MM; Yao, M; Zhou, W, 2005) |
| "Ibuprofen (1200 mg/d) was administered for 8-11 days." | 6.68 | Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients. ( Cooke, TG; Leen, E; McArdle, CS; McMillan, DC; Preston, T; Smith, J; Sturgeon, C, 1995) |
| "A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant BRAF and both events proved to cooperate in tumor cell survival." | 5.39 | Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. ( Chastre, E; Goncalves, V; Henriques, A; Henriques, AF; Jordan, P; Kotelevets, L; Matos, P; Moyer, MP; Zerbib, P, 2013) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 5.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "With 13 years of follow-up, the authors prospectively evaluated the association between aspirin and ibuprofen use and incident distal adenoma (1221 cases), recurrent adenoma (862 cases), and incident colorectal cancer (CRC; 2826 cases) among men and women in the population-based Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial." | 4.02 | Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial. ( Barry, KH; Berndt, SI; Chudy-Onwugaje, K; Huang, WY; Johnson, CC; Katki, HA; Purdue, MP; Su, LJ; Wang, L, 2021) |
| " Use of aspirin has been shown to be associated with a reduced risk of colorectal cancer for the general population as well as for MMR gene mutation carriers." | 3.81 | Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome. ( Ahnen, DJ; Ait Ouakrim, D; Baron, JA; Buchanan, DD; Casey, G; Chau, R; Clendenning, M; Dashti, SG; Gallinger, S; Giles, GG; Haile, RW; Hopper, JL; Jenkins, MA; Le Marchand, L; Leggett, B; Lindor, NM; Macrae, FA; Newcomb, PA; Potter, JD; Rosty, C; Thibodeau, SN; Win, AK; Winship, IM; Young, JP, 2015) |
| "Diclofenac treatment could result in an increased proportion of patients with anastomotic leakage after colorectal surgery." | 3.78 | Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. ( Gögenur, I; Klein, M; Rosenberg, J, 2012) |
| "To determine whether the nonselective and relatively inexpensive nonsteroidal anti-inflammatory drug ibuprofen would be effective in inhibiting colorectal cancer and might improve mortality in a mouse model." | 3.73 | Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer. ( Albert, A; Chang, AJ; Liu, TC; Sangha, S; Wolfe, MM; Yao, M; Zhou, W, 2005) |
| "Ibuprofen (1200 mg/d) was administered for 8-11 days." | 2.68 | Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients. ( Cooke, TG; Leen, E; McArdle, CS; McMillan, DC; Preston, T; Smith, J; Sturgeon, C, 1995) |
| "3 patients in the colorectal cancer group demonstrated objective responses (1 complete remission (CR), 2 partial remission (PR))." | 2.68 | Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer. ( Braun, M; Engelhardt, R; Galanos, C; Mackensen, A; Mertelsmann, R; Otto, F; Schmid, P; Seiz, A; Wehr, U, 1996) |
| "Ibuprofen is a non-steroidal anti-inflammatory drug of generalized use with over-the-counter availability." | 2.52 | Beyond COX-inhibition: 'side-effects' of ibuprofen on neoplastic development and progression. ( Jordan, P; Matos, P, 2015) |
| " To evaluate THEDES anti-CRC therapeutic potential, their physico-chemical properties, bioavailability and bioactivity, were explored." | 1.72 | Selective terpene based therapeutic deep eutectic systems against colorectal cancer. ( Duarte, ARC; Miguel Castro, M; Oliveira, F; Paiva, A; Pereira, J; Rita Jesus, A; Santos, F, 2022) |
| "A previous analysis of colorectal tumors revealed that overexpression of splice variant Rac1b occurs in around 80% of tumors with mutant BRAF and both events proved to cooperate in tumor cell survival." | 1.39 | Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b. ( Chastre, E; Goncalves, V; Henriques, A; Henriques, AF; Jordan, P; Kotelevets, L; Matos, P; Moyer, MP; Zerbib, P, 2013) |
| "NSAID use prior to colorectal cancer diagnosis was associated with an ~20% lower rate of colorectal cancer mortality after diagnosis compared with never use (HR 0." | 1.37 | Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer. ( Adams, SV; Burnett-Hartman, AN; Campbell, PT; Coghill, AE; Newcomb, PA; Poole, EM; Potter, JD; Ulrich, CM, 2011) |
| "Aspirin was the most prospective chemopreventive agents for colorectal polyp, colon and rectal carcinoma for its capability of reducing the risk of cardio-cerebral vascular disease as well." | 1.31 | [Nonsteroidal anti-inflammatory drugs and the risk of polyposis, colon carcinoma and rectal carcinoma]. ( Gao, X; Li, M; Song, S; Sun, F; Sun, H; Sun, S; Zhang, W, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 3 (15.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pereira, J | 1 |
| Miguel Castro, M | 1 |
| Santos, F | 1 |
| Rita Jesus, A | 1 |
| Paiva, A | 1 |
| Oliveira, F | 1 |
| Duarte, ARC | 1 |
| Sharma, C | 1 |
| Kang, SC | 1 |
| Chudy-Onwugaje, K | 1 |
| Huang, WY | 1 |
| Su, LJ | 1 |
| Purdue, MP | 2 |
| Johnson, CC | 1 |
| Wang, L | 1 |
| Katki, HA | 2 |
| Barry, KH | 1 |
| Berndt, SI | 1 |
| Sahin, A | 1 |
| Spiroux, F | 1 |
| Guedon, I | 1 |
| Arslan, FB | 1 |
| Sarcan, ET | 1 |
| Ozkan, T | 1 |
| Colak, N | 1 |
| Yuksel, S | 1 |
| Ozdemir, S | 1 |
| Ozdemir, B | 1 |
| Akbas, S | 1 |
| Ultav, G | 1 |
| Aktas, Y | 1 |
| Capan, Y | 1 |
| Lang Kuhs, KA | 1 |
| Hildesheim, A | 1 |
| Trabert, B | 1 |
| Kemp, TJ | 1 |
| Wentzensen, N | 1 |
| Pinto, LA | 1 |
| Loftfield, E | 1 |
| Safaeian, M | 1 |
| Chaturvedi, AK | 1 |
| Shiels, MS | 1 |
| Matos, P | 2 |
| Jordan, P | 2 |
| Ait Ouakrim, D | 2 |
| Dashti, SG | 2 |
| Chau, R | 1 |
| Buchanan, DD | 1 |
| Clendenning, M | 1 |
| Rosty, C | 1 |
| Winship, IM | 1 |
| Young, JP | 1 |
| Giles, GG | 1 |
| Leggett, B | 1 |
| Macrae, FA | 1 |
| Ahnen, DJ | 1 |
| Casey, G | 1 |
| Gallinger, S | 1 |
| Haile, RW | 1 |
| Le Marchand, L | 1 |
| Thibodeau, SN | 1 |
| Lindor, NM | 1 |
| Newcomb, PA | 2 |
| Potter, JD | 3 |
| Baron, JA | 1 |
| Hopper, JL | 1 |
| Jenkins, MA | 1 |
| Win, AK | 2 |
| Tuccori, M | 1 |
| Filion, KB | 1 |
| Azoulay, L | 1 |
| Zell, JA | 1 |
| Ziogas, A | 1 |
| Bernstein, L | 1 |
| Clarke, CA | 1 |
| Deapen, D | 1 |
| Largent, JA | 1 |
| Neuhausen, SL | 1 |
| Stram, DO | 1 |
| Ursin, G | 1 |
| Anton-Culver, H | 1 |
| Coghill, AE | 1 |
| Campbell, PT | 1 |
| Burnett-Hartman, AN | 1 |
| Adams, SV | 1 |
| Poole, EM | 1 |
| Ulrich, CM | 1 |
| Brasky, TM | 1 |
| Kristal, AR | 1 |
| Patterson, RE | 1 |
| Peters, U | 1 |
| Asgari, MM | 1 |
| Thornquist, MD | 1 |
| White, E | 1 |
| Klein, M | 1 |
| Gögenur, I | 1 |
| Rosenberg, J | 1 |
| Kotelevets, L | 1 |
| Goncalves, V | 1 |
| Henriques, AF | 1 |
| Henriques, A | 1 |
| Zerbib, P | 1 |
| Moyer, MP | 1 |
| Chastre, E | 1 |
| Gao, X | 1 |
| Sun, S | 1 |
| Sun, F | 1 |
| Li, M | 1 |
| Sun, H | 1 |
| Zhang, W | 1 |
| Song, S | 1 |
| Yao, M | 1 |
| Zhou, W | 1 |
| Sangha, S | 1 |
| Albert, A | 1 |
| Chang, AJ | 1 |
| Liu, TC | 1 |
| Wolfe, MM | 1 |
| McMillan, DC | 1 |
| Leen, E | 1 |
| Smith, J | 1 |
| Sturgeon, C | 1 |
| Preston, T | 1 |
| Cooke, TG | 1 |
| McArdle, CS | 1 |
| Otto, F | 1 |
| Schmid, P | 1 |
| Mackensen, A | 1 |
| Wehr, U | 1 |
| Seiz, A | 1 |
| Braun, M | 1 |
| Galanos, C | 1 |
| Mertelsmann, R | 1 |
| Engelhardt, R | 1 |
| Hara, A | 1 |
| Yoshimi, N | 1 |
| Niwa, M | 1 |
| Ino, N | 1 |
| Mori, H | 1 |
| Collins, CL | 1 |
| DeTullio, PL | 1 |
| Berardi, RR | 1 |
| Elta, GH | 1 |
| Patterson, RW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects on Omission of NSAIDs on the Consumption of Opioids in the Standard Analgesic Regimen After Elective Laparoscopic Colorectal Cancer Resection in an ERAS Setting. A Retrospective Single-center Cohort Study.[NCT04448652] | 502 participants (Actual) | Observational [Patient Registry] | 2015-01-01 | Completed | |||
| Feasibility Study of Intra-Tumoral Lipopolysaccharide Immunotherapy for Intra-Abdominal[NCT05751837] | Phase 1 | 6 participants (Anticipated) | Interventional | 2023-03-16 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ibuprofen and Colorectal Cancer
| Article | Year |
|---|---|
Beyond COX-inhibition: 'side-effects' of ibuprofen on neoplastic development and progression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Colorectal Neoplasms; Cyclooxy | 2015 |
3 trials available for ibuprofen and Colorectal Cancer
| Article | Year |
|---|---|
Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Colorectal Neoplasms; Early Dete | 2015 |
Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients.
Topics: Acute-Phase Proteins; Adult; Aged; C-Reactive Protein; Carcinoembryonic Antigen; Colorectal Neoplasm | 1995 |
Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bacterial Toxins; Carcinoma, Non-Small-Cell Lu | 1996 |
16 other studies available for ibuprofen and Colorectal Cancer
| Article | Year |
|---|---|
Selective terpene based therapeutic deep eutectic systems against colorectal cancer.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Caspase 3; Colorectal Neoplasms; Humans; Ibuprofen; Inflamm | 2022 |
Molecular dynamic simulation (MDS) and
Topics: Benzopyrans; Butyrates; Cathepsin B; Colorectal Neoplasms; HCT116 Cells; Humans; Ibuprofen; Molecula | 2022 |
Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial.
Topics: Adenoma; Aged; Aspirin; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Ibuprofen; | 2021 |
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu | 2017 |
Aspirin, Ibuprofen, and the Risk of Colorectal Cancer in Lynch Syndrome.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Adult; Aged; Anti-Inflammatory Agen | 2015 |
RE: Aspirin, Ibuprofen, and the Risk for Colorectal Cancer in Lynch Syndrome.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal Neoplasms; Col | 2016 |
Response.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Aspirin; Colorectal Neoplasms; Col | 2016 |
Meat consumption, nonsteroidal anti-inflammatory drug use, and mortality among colorectal cancer patients in the California Teachers Study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; California; Colore | 2010 |
Prediagnostic non-steroidal anti-inflammatory drug use and survival after diagnosis of colorectal cancer.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Drug Administra | 2011 |
Non-steroidal anti-inflammatory drugs and cancer incidence by sex in the VITamins And Lifestyle (VITAL) cohort.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Colorectal Neoplasms; Confidence Intervals; Female; H | 2012 |
Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data.
Topics: Aged; Anastomotic Leak; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Colorectal Neoplasm | 2012 |
Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1b.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Colitis; Colorectal Neoplasms; Down-Regu | 2013 |
[Nonsteroidal anti-inflammatory drugs and the risk of polyposis, colon carcinoma and rectal carcinoma].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colorectal Neoplasms; Female; Humans; Ibupr | 2002 |
Effects of nonselective cyclooxygenase inhibition with low-dose ibuprofen on tumor growth, angiogenesis, metastasis, and survival in a mouse model of colorectal cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Camptothecin; Cell Line, | 2005 |
Apoptosis induced by NS-398, a selective cyclooxygenase-2 inhibitor, in human colorectal cancer cell lines.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cell Division; Colorectal Neoplasms; Cyclooxygen | 1997 |
Comparison of home occult blood tests and interaction of tests with ibuprofen.
Topics: Adult; Colorectal Neoplasms; False Positive Reactions; Humans; Ibuprofen; Male; Occult Blood | 1989 |