ibuprofen has been researched along with Cancer of Prostate in 22 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 9.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "Regular aspirin use may decrease cancer risk by reducing chronic inflammation." | 5.20 | Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. ( Chaturvedi, AK; Hildesheim, A; Katki, HA; Kemp, TJ; Lang Kuhs, KA; Loftfield, E; Pinto, LA; Purdue, MP; Safaeian, M; Shiels, MS; Trabert, B; Wentzensen, N, 2015) |
| "Expression of p75(NTR) is lost as prostate cancer progresses and is minimal in several metastatic prostate cancer cell lines." | 1.36 | NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway. ( Djakiew, D; Wynne, S, 2010) |
| "Overall, prostate cancer was not related to AMACR gene variants; however, risks for prostate cancer were significantly reduced among regular ibuprofen users who carried allele variants at four nsSNP loci (M9V, D175G, S201L, and K277E; all P(trend) < 0." | 1.34 | Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer. ( Daugherty, SE; Fallin, MD; Hayes, RB; Huang, WY; Isaacs, WB; Pfeiffer, RM; Platz, EA; Reding, D; Shugart, YY; Welch, R, 2007) |
| "Ibuprofen was significantly more effective against human prostate cancer cells in vitro than the other tested nonprescription NSAIDs." | 1.31 | Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells. ( Andrews, J; Andrews, P; Djakiew, D; Krygier, S, 2002) |
| "DU-145 and PC-3 human prostate cancer cell lines were used to test the effect of inhibitors of PLA2, COX, or LOX on the invasion of prostate tumor cells through Matrigel in vitro using the Boyden chamber assay and fibroblast-conditioned medium as the chemoattractant." | 1.31 | Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. ( Attiga, FA; Fernandez, PM; Manyak, MJ; Patierno, SR; Weeraratna, AT, 2000) |
| "Finally, prostate cancer cells fed with arachidonic acid showed a dramatic increase in the production of 5-HETEs which is effectively blocked by MK886." | 1.30 | Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase. ( Ghosh, J; Myers, CE, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.55) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 13 (59.09) | 29.6817 |
| 2010's | 4 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Festuccia, C | 1 |
| Gravina, GL | 1 |
| Mancini, A | 1 |
| Muzi, P | 1 |
| Cesare, ED | 1 |
| Kirk, R | 1 |
| Smith, M | 1 |
| Hughes, S | 1 |
| Gibson, R | 1 |
| Lian, LY | 1 |
| Ricevuto, E | 1 |
| Carnell, AJ | 1 |
| Lang Kuhs, KA | 1 |
| Hildesheim, A | 1 |
| Trabert, B | 1 |
| Kemp, TJ | 1 |
| Purdue, MP | 1 |
| Wentzensen, N | 1 |
| Katki, HA | 1 |
| Pinto, LA | 1 |
| Loftfield, E | 1 |
| Safaeian, M | 1 |
| Chaturvedi, AK | 1 |
| Shiels, MS | 1 |
| John-Aryankalayil, M | 1 |
| Palayoor, ST | 4 |
| Cerna, D | 1 |
| Falduto, MT | 1 |
| Magnuson, SR | 1 |
| Coleman, CN | 6 |
| Seth, A | 1 |
| Anderson, DP | 1 |
| Albiani, DA | 1 |
| Barton, JJ | 1 |
| Wynne, S | 1 |
| Djakiew, D | 4 |
| Shebl, FM | 1 |
| Sakoda, LC | 1 |
| Black, A | 1 |
| Koshiol, J | 1 |
| Andriole, GL | 1 |
| Grubb, R | 1 |
| Church, TR | 1 |
| Chia, D | 1 |
| Zhou, C | 1 |
| Chu, LW | 1 |
| Huang, WY | 2 |
| Peters, U | 1 |
| Kirsh, VA | 1 |
| Chatterjee, N | 1 |
| Leitzmann, MF | 1 |
| Hayes, RB | 2 |
| Hsing, AW | 1 |
| Kelly, L | 1 |
| Riese Daly, N | 1 |
| Beard, C | 1 |
| Kaplan, I | 1 |
| Lamb, C | 1 |
| Propert, K | 1 |
| Manola, J | 1 |
| Andrews, J | 1 |
| Krygier, S | 1 |
| Andrews, P | 1 |
| Tofilon, PJ | 1 |
| Camphausen, K | 1 |
| Ménard, C | 1 |
| Sproull, M | 1 |
| Goley, E | 1 |
| Basu, S | 1 |
| Royle, JS | 1 |
| Ross, JA | 1 |
| Ansell, I | 1 |
| Bollina, P | 1 |
| Tulloch, DN | 1 |
| Habib, FK | 1 |
| Quann, EJ | 2 |
| Khwaja, F | 2 |
| Zavitz, KH | 1 |
| Daugherty, SE | 1 |
| Shugart, YY | 1 |
| Platz, EA | 1 |
| Fallin, MD | 1 |
| Isaacs, WB | 1 |
| Pfeiffer, RM | 1 |
| Welch, R | 1 |
| Reding, D | 1 |
| Kim, MH | 1 |
| Ghosh, J | 2 |
| Myers, CE | 2 |
| Bump, EA | 1 |
| Calderwood, SK | 2 |
| Bartol, S | 1 |
| Youmell, MY | 1 |
| Price, BD | 1 |
| Attiga, FA | 1 |
| Fernandez, PM | 1 |
| Weeraratna, AT | 1 |
| Manyak, MJ | 1 |
| Patierno, SR | 1 |
| Kasof, GM | 1 |
| Lu, JJ | 1 |
| Liu, D | 1 |
| Speer, B | 1 |
| Mongan, KN | 1 |
| Gomes, BC | 1 |
| Lorenzi, MV | 1 |
| Cameron, DJ | 1 |
| O'Brien, P | 1 |
| Majeski, JA | 1 |
3 trials available for ibuprofen and Cancer of Prostate
| Article | Year |
|---|---|
Association between Regular Aspirin Use and Circulating Markers of Inflammation: A Study within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers; Colorectal Neoplasms; Early Dete | 2015 |
Phase III study of ibuprofen versus placebo for radiation-induced genitourinary side effects.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Double- | 2002 |
Isoprostane levels in the urine of patients with prostate cancer receiving radiotherapy are not elevated.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, Tumor; Creatinine; Dinoprost; Humans; Ibuprofen | 2004 |
19 other studies available for ibuprofen and Cancer of Prostate
| Article | Year |
|---|---|
Trifluoroibuprofen inhibits α-methylacyl coenzyme A racemase (AMACR/P504S), reduces cancer cell proliferation and inhibits in vivo tumor growth in aggressive prostate cancer models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferat | 2014 |
NS-398, ibuprofen, and cyclooxygenase-2 RNA interference produce significantly different gene expression profiles in prostate cancer cells.
Topics: Angiopoietin-Like Protein 4; Angiopoietins; Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumo | 2009 |
Orbital inflammation and optic neuropathy with zoledronic acid for metastatic prostate cancer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Diphosphonates; Dru | 2009 |
NSAID inhibition of prostate cancer cell migration is mediated by Nag-1 Induction via the p38 MAPK-p75(NTR) pathway.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Line, Tumor; Cell Movement; Flurbiprofen; Growth Diffe | 2010 |
Aspirin but not ibuprofen use is associated with reduced risk of prostate cancer: a PLCO study.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Humans; Ibuprofen; Male; Middle | 2012 |
Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Divis | 2002 |
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tu | 2003 |
Nitric oxide donating nonsteroidal anti-inflammatory drugs induce apoptosis in human prostate cancer cell systems and human prostatic stroma via caspase-3.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Caspase 3; Caspases; Cell Division; Col | 2004 |
The aryl propionic acid R-flurbiprofen selectively induces p75NTR-dependent decreased survival of prostate tumor cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Dose-Response Relationship, Drug; Flurbiprof | 2007 |
Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Chemoprevention; Genetic Marker | 2007 |
The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Eukaryotic Initiation Factor-4E; Flurbiprofen; Humans; Ibup | 2007 |
Protein phosphatase 1 activation and alternative splicing of Bcl-X and Mcl-1 by EGCG + ibuprofen.
Topics: Alternative Splicing; bcl-X Protein; Catechin; Cell Line, Tumor; Drug Synergism; Enzyme Activation; | 2008 |
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenase.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Benzoquinones; Cell Division; Cycl | 1997 |
Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Survival; DNA Fragmentation; Ga | 1998 |
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Antineoplastic Agents; Apoptosis; Cell Membrane; Dietary | 1998 |
Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Enzyme Activation; Gene Expression Regulation, Enzymologic; | 1999 |
Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
Topics: 3T3 Cells; Acetophenones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cell M | 2000 |
Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; bcl-X Protein; Chromosome Mapping; Chromosomes, | 2001 |
Effects of in vivo treatment with ibuprofen on macrophage function in breast and colon cancer patients.
Topics: Breast Neoplasms; Cell Line; Cells, Cultured; Centrifugation, Density Gradient; Colonic Neoplasms; C | 1986 |