ibuprofen has been researched along with Cancer of Colon in 30 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ibuprofen treatment reduced skeletal muscle wasting, inflammation in the brain, and fatigue- and depressive-like behavior in tumor-bearing mice." | 7.81 | Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. ( Bicer, S; Devine, RD; Godbout, JP; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| " In this study, we investigated the effects of long-term use (up to 25 years) of NSAIDs (ibuprofen or aspirin) on adenoma pathology and β-catenin-mediated signaling in sporadic human colon adenomas." | 7.77 | Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. ( Boardman, LA; Greenspan, EJ; Madigan, JP; Rosenberg, DW, 2011) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 7.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| "alpha-Methylacyl-CoA racemase (AMACR), an enzyme involved in oxidation of branched chain fatty acids and cholesterol metabolites, as well as ibuprofen metabolism, is overexpressed in colorectal adenomas and cancer." | 5.12 | Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. ( Chatterjee, N; Daugherty, SE; Fallin, MD; Hayes, RB; Huang, WY; Isaacs, WB; Platz, EA; Shugart, YY; Welch, R, 2007) |
| "Ibuprofen treatment reduced skeletal muscle wasting, inflammation in the brain, and fatigue- and depressive-like behavior in tumor-bearing mice." | 3.81 | Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. ( Bicer, S; Devine, RD; Godbout, JP; McCarthy, DO; Norden, DM; Reiser, PJ; Wold, LE, 2015) |
| " Fisher 344 rats were injected with azoxymethane then treated with either ibuprofen (500 ppm) or p-ibuprofen (900 ppm) for 20 weeks to observe aberrant crypt foci (ACF) or 40 weeks to evaluate tumor incidence and multiplicity." | 3.79 | A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats. ( Ji, P; Ouyang, N; Williams, JL, 2013) |
| " In this study, we investigated the effects of long-term use (up to 25 years) of NSAIDs (ibuprofen or aspirin) on adenoma pathology and β-catenin-mediated signaling in sporadic human colon adenomas." | 3.77 | Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}. ( Boardman, LA; Greenspan, EJ; Madigan, JP; Rosenberg, DW, 2011) |
| " We report that both indomethacin and ibuprofen improved body weight and weight of the gastrocnemius muscle in tumor-bearing mice." | 3.72 | Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma. ( Al-Majid, S; Hitt, A; McCarthy, DO; Whitney, P, 2004) |
| " Intravenous administration of PI-PEG resulted in significant levels in blood and in colon cancer xenografts (xenograft values in parentheses): area under the curve for 0-24 hours = 2351 (2621) (nmol/g) × h; Cmax = 1965 (886) nmol/g; Tmax = 0." | 1.40 | Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen. ( Amella, CA; Constantinides, PP; Mattheolabakis, G; Richards, R; Rigas, B; Sun, Y; Wong, CC, 2014) |
| "Liposome encapsulation of P-I partially protected P-I from esterase-mediated hydrolysis in mice, enhanced the cytotoxicity and bioavailability of P-I and increased its efficacy at inhibiting the growth of human colon cancer xenografts." | 1.38 | Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-cancer activity in vitro and in vivo. ( Alston, N; Aro, P; Constantinides, PP; Nie, T; Rigas, B; Wong, CC, 2012) |
| "Data were available from 1,577 cases of colon cancer that were matched to 1,971 population-based controls and 794 cases of rectal cancer that were matched to 1,001 population-based controls." | 1.33 | PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States). ( Curtin, K; Levin, TR; Ma, KN; Murtaugh, M; Potter, JD; Samowitz, W; Slattery, ML; Sweeney, C; Wolff, R, 2006) |
| "Variant CYP2C9 genotypes enhanced the protective effect of ibuprofen on the prevention of colorectal cancer, and a dose-response relationship with respect to increasing numbers of variant alleles was seen (P interaction = ." | 1.33 | Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. ( Andersen, K; Curtin, K; Levin, TR; Ma, KN; Samowitz, WS; Slattery, ML; Sweeney, C; Wolff, RK, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.33) | 18.7374 |
| 1990's | 6 (20.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 15 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, W | 1 |
| Zhou, J | 1 |
| Zhang, T | 1 |
| Zhu, H | 1 |
| Qian, H | 1 |
| Zhang, H | 1 |
| Huang, W | 1 |
| Gust, R | 1 |
| Bhardwaj, A | 2 |
| Kaur, J | 2 |
| Sharma, SK | 1 |
| Huang, Z | 1 |
| Wuest, F | 2 |
| Knaus, EE | 2 |
| Lennerz, JK | 1 |
| Lauwers, GY | 1 |
| Todo, M | 1 |
| Horinaka, M | 1 |
| Tomosugi, M | 1 |
| Tanaka, R | 1 |
| Ikawa, H | 1 |
| Sowa, Y | 1 |
| Ishikawa, H | 1 |
| Fujiwara, H | 1 |
| Otsuji, E | 1 |
| Sakai, T | 1 |
| Mattheolabakis, G | 2 |
| Wong, CC | 2 |
| Sun, Y | 2 |
| Amella, CA | 1 |
| Richards, R | 1 |
| Constantinides, PP | 3 |
| Rigas, B | 5 |
| Norden, DM | 1 |
| McCarthy, DO | 2 |
| Bicer, S | 1 |
| Devine, RD | 1 |
| Reiser, PJ | 1 |
| Godbout, JP | 1 |
| Wold, LE | 1 |
| Hasegawa, U | 1 |
| Wang, T | 1 |
| Chen, JJ | 1 |
| Uyama, H | 1 |
| van der Vlies, AJ | 1 |
| Torup, H | 1 |
| Hansen, EG | 1 |
| Bøgeskov, M | 1 |
| Rosenberg, J | 1 |
| Mitchell, AU | 1 |
| Petersen, PL | 1 |
| Mathiesen, O | 1 |
| Dahl, JB | 1 |
| Møller, AM | 1 |
| Ahmetaj-Shala, B | 1 |
| Tesfai, A | 1 |
| Constantinou, C | 1 |
| Leszczynski, R | 1 |
| Chan, MV | 1 |
| Gashaw, H | 1 |
| Galaris, G | 1 |
| Mazi, S | 1 |
| Warner, TD | 1 |
| Kirkby, NS | 1 |
| Mitchell, JA | 1 |
| Greenspan, EJ | 1 |
| Madigan, JP | 1 |
| Boardman, LA | 1 |
| Rosenberg, DW | 1 |
| Xie, G | 1 |
| Nie, T | 3 |
| Mackenzie, GG | 1 |
| Huang, L | 1 |
| Kopelovich, L | 1 |
| Komninou, D | 1 |
| Alston, N | 1 |
| Aro, P | 1 |
| Ouyang, N | 1 |
| Ji, P | 1 |
| Williams, JL | 2 |
| Coady, MJ | 1 |
| Chang, MH | 1 |
| Charron, FM | 1 |
| Plata, C | 1 |
| Wallendorff, B | 1 |
| Sah, JF | 1 |
| Markowitz, SD | 1 |
| Romero, MF | 1 |
| Lapointe, JY | 1 |
| Whitney, P | 1 |
| Hitt, A | 1 |
| Al-Majid, S | 1 |
| Dial, EJ | 1 |
| Doyen, JR | 1 |
| Lichtenberger, LM | 1 |
| Slattery, ML | 2 |
| Curtin, K | 2 |
| Wolff, R | 1 |
| Ma, KN | 2 |
| Sweeney, C | 2 |
| Murtaugh, M | 1 |
| Potter, JD | 1 |
| Levin, TR | 2 |
| Samowitz, W | 1 |
| Janssen, A | 1 |
| Maier, TJ | 1 |
| Schiffmann, S | 1 |
| Coste, O | 1 |
| Seegel, M | 1 |
| Geisslinger, G | 1 |
| Grösch, S | 1 |
| Samowitz, WS | 1 |
| Wolff, RK | 1 |
| Andersen, K | 1 |
| Daugherty, SE | 1 |
| Platz, EA | 1 |
| Shugart, YY | 1 |
| Fallin, MD | 1 |
| Isaacs, WB | 1 |
| Chatterjee, N | 1 |
| Welch, R | 1 |
| Huang, WY | 1 |
| Hayes, RB | 1 |
| Preston, T | 1 |
| Fearon, KC | 1 |
| McMillan, DC | 1 |
| Winstanley, FP | 1 |
| Slater, C | 1 |
| Shenkin, A | 1 |
| Carter, DC | 1 |
| Wargovich, MJ | 1 |
| Chen, CD | 1 |
| Harris, C | 1 |
| Yang, E | 1 |
| Velasco, M | 1 |
| Reddy, BS | 2 |
| Van Lieshout, EM | 1 |
| Tiemessen, DM | 1 |
| Roelofs, HM | 1 |
| Peters, WH | 1 |
| Schwenger, P | 1 |
| Alpert, D | 1 |
| Skolnik, EY | 1 |
| Vilcek, J | 1 |
| Borgo, S | 1 |
| Hasan, I | 1 |
| Castillo, E | 1 |
| Traganos, F | 1 |
| Tokumo, K | 1 |
| Kulkarni, N | 1 |
| Aligia, C | 1 |
| Kelloff, G | 1 |
| Cameron, DJ | 1 |
| O'Brien, P | 1 |
| Majeski, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Transversus Abdominis Plane (TAP) Block as Postoperative Pain Management After Laparoscopic Colon Surgery[NCT01418144] | Phase 4 | 80 participants (Actual) | Interventional | 2010-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ibuprofen and Cancer of Colon
| Article | Year |
|---|---|
Chemoprevention of colon cancer by dietary administration of naturally-occurring and related synthetic agents.
Topics: Allyl Compounds; Anethole Trithione; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinoge | 1997 |
3 trials available for ibuprofen and Cancer of Colon
| Article | Year |
|---|---|
Transversus abdominis plane block after laparoscopic colonic resection in cancer patients: A randomised clinical trial.
Topics: Abdominal Muscles; Acetaminophen; Aged; Colectomy; Colonic Neoplasms; Denmark; Double-Blind Method; | 2016 |
Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma.
Topics: Adenoma; Aged; Alleles; Anti-Inflammatory Agents, Non-Steroidal; Aspartic Acid; Case-Control Studies | 2007 |
Effect of ibuprofen on the acute-phase response and protein metabolism in patients with cancer and weight loss.
Topics: Acute-Phase Proteins; Acute-Phase Reaction; Adult; Aged; C-Reactive Protein; Colonic Neoplasms; Fema | 1995 |
26 other studies available for ibuprofen and Cancer of Colon
| Article | Year |
|---|---|
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L | 2012 |
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.
Topics: Acridines; Acridones; Biomarkers, Tumor; Celecoxib; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygen | 2013 |
Amelanotic adenoma.
Topics: Adenoma; Butanones; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; Female; Humans; Ibuprofen; Intes | 2013 |
Ibuprofen enhances TRAIL-induced apoptosis through DR5 upregulation.
Topics: Apoptosis; Colonic Neoplasms; Drug Synergism; Gene Expression Regulation, Neoplastic; HCT116 Cells; | 2013 |
Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: synthesis and biological studies.
Topics: 4-Chloro-7-nitrobenzofurazan; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Line, Tumor; | 2014 |
Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.
Topics: Animals; Antineoplastic Agents; Carboxylic Ester Hydrolases; Cell Line, Tumor; Colonic Neoplasms; HE | 2014 |
Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Depression; Fatigue; Female; Ib | 2015 |
Furoxan-Bearing Micelles for Nitric Oxide Delivery.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Humans; Hydrophobic and Hydrophilic Interactions | 2016 |
Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Arginine; Caco-2 Cells; C | 2017 |
Ibuprofen inhibits activation of nuclear {beta}-catenin in human colon adenomas and induces the phosphorylation of GSK-3{beta}.
Topics: Adenoma; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; beta Catenin; Blotting, West | 2011 |
Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Esterases; Female; HT29 Cells; Humans; Ibuprofen; | 2011 |
Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): preparation, characterization, and in vitro/in vivo evaluation.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemistry, P | 2012 |
Phospho-ibuprofen (MDC-917) incorporated in nanocarriers: anti-cancer activity in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Colonic Ne | 2012 |
A novel NSAID derivative, phospho-ibuprofen, prevents AOM-induced colon cancer in rats.
Topics: Aberrant Crypt Foci; Animals; Anticarcinogenic Agents; Azoxymethane; beta Catenin; Carcinogens; Colo | 2013 |
The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter.
Topics: Animals; Carboxylic Acids; Cation Transport Proteins; Cell Membrane; Colon; Colonic Neoplasms; Cyclo | 2004 |
Indomethacin and ibuprofen preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cachexia; Colonic Neo | 2004 |
Phosphatidylcholine-associated nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit DNA synthesis and the growth of colon cancer cells in vitro.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Aspirin; Cell Line, Tumor; Cell Proliferation; C | 2006 |
PPARgamma and colon and rectal cancer: associations with specific tumor mutations, aspirin, ibuprofen and insulin-related genes (United States).
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; California; Case-Control Studies; Col | 2006 |
Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.
Topics: Animals; Apoptosis; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proli | 2006 |
Interactions between CYP2C9 and UGT1A6 polymorphisms and nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aryl Hydrocarbon Hydroxylases; Aspirin; Case-C | 2006 |
Inhibition of aberrant crypt growth by non-steroidal anti-inflammatory agents and differentiation agents in the rat colon.
Topics: Acetaminophen; Adenoma; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1995 |
Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Butanones; Colon; Colonic Neoplasms; Diet | 1998 |
Cell-type-specific activation of c-Jun N-terminal kinase by salicylates.
Topics: Acetaminophen; Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Calcium-Ca | 1999 |
Nitric oxide-releasing nonsteroidal anti-inflammatory drugs (NSAIDs) alter the kinetics of human colon cancer cell lines more effectively than traditional NSAIDs: implications for colon cancer chemoprevention.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Apoptosis; Aspirin | 2001 |
Inhibition of colon carcinogenesis by prostaglandin synthesis inhibitors and related compounds.
Topics: Animals; Azoxymethane; Colonic Neoplasms; Glycyrrhetinic Acid; Ibuprofen; Ketoprofen; Male; Piroxica | 1992 |
Effects of in vivo treatment with ibuprofen on macrophage function in breast and colon cancer patients.
Topics: Breast Neoplasms; Cell Line; Cells, Cultured; Centrifugation, Density Gradient; Colonic Neoplasms; C | 1986 |