Page last updated: 2024-10-28

ibuprofen and Burns

ibuprofen has been researched along with Burns in 37 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

ExcerptRelevanceReference
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."7.71Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
"The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns."7.70Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000)
"We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor."7.67Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987)
"To evaluate the efficacy of ibuprofen-containing foam dressing in partial-thickness burns."5.69Pain Management With Topical Ibuprofen in Partial-Thickness Burn Wounds and Effects on Wound Healing: A Prospective Randomized Clinical Study. ( Akgun, AE; Alkin, M, 2023)
" Spinal pretreatment with cyclooxygenase (10 and 30 microg (S)-(+)-ibuprofen; and 3 and 30 microg ketorolac) and nitric oxide synthase (33 and 100 microg N(G) Nitro-L-arginine methyl ester hydrochloride (L-NAME) and 10 microg thiocitrulline) inhibitors resulted in no specific anti-allodynia."3.74Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase. ( Doom, CM; Maruyama, KP; Nanigian, DB; Sorkin, LS, 2008)
"This study suggests that Ibuprofen has no preventive effect on progressive dermal ischemia after burning."3.71Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs. ( Chen, H; Lin, Z; Ma, W; Ning, G; Tan, Q; Wang, L; Zhou, X, 2002)
"The anti-inflammatory and anticoagulant effects of ibuprofen and heparin may enhance skin perfusion in cutaneous scald burns."3.70Ibuprofen modulates tissue perfusion in partial-thickness burns. ( Barrow, RE; Ramirez, RJ; Zhang, XJ, 2000)
"A group of 15 burned children and young adults with large burns (mean, 41% +/- 15% BSA) were administered ibuprofen (40 mg/kg for 3 days)."3.68Ibuprofen lowers body temperature and metabolic rate of humans with burn injury. ( Caldwell, FT; Cone, JB; Wallace, BH, 1992)
"We determined the effect of topically applied ibuprofen on formation of second-degree burn edema and prostanoid production, a possible causative factor."3.67Topical ibuprofen decreases early postburn edema. ( Demling, RH; Lalonde, C, 1987)
"We injected Escherichia coli endotoxin, 2 micrograms/kg, beneath the eschar of sheep with 25% total body surface full-thickness burns to determine whether burn tissue in the presence of endotoxin releases prostanoids, particularly thromboxane A2, (TxA2), and if increased local TxA2 production can lead to distant lung dysfunction."3.67Endotoxin-induced prostanoid production by the burn wound can cause distant lung dysfunction. ( Demling, RH; Hechtman, H; Lalonde, CC; Wenger, H; West, K; Wong, C, 1986)
"Ibuprofen was found to decrease neutrophil chemiluminescence, lymphocyte blastogenesis, and helper/inducer T-lymphocyte infiltration of a sponge matrix model."1.29Effect of ibuprofen on the inflammatory response to surgical wounds. ( Dong, YL; Fleming, RY; Herndon, DN; Waymack, JP; Yan, TZ, 1993)
"Ibuprofen at high doses was found to significantly diminish the hypermetabolic response to burn injury and sepsis."1.28The effect of ibuprofen on postburn metabolic and immunologic function. ( Waymack, JP, 1989)
"Standard burns were sequentially produced on the backs of Sprague-Dawley rats at 0, 1, 2, and 2 1/2 hr, followed by the IV injection of Evans blue dye."1.27Arachidonic acid metabolites mediate early burn edema. ( Alexander, F; Hechtman, HB; Huval, WV; Lelcuk, S; Mathieson, M; Shepro, D; Teoh, KH; Valeri, CR, 1984)
"These alterations were not due to pulmonary edema as there was no increase in measured lung water."1.27Early lung dysfunction after major burns: role of edema and vasoactive mediators. ( Demling, RH; Hechtman, H; Jin, LJ; Lalonde, C; West, K; Wong, C, 1985)
" Animals were then treated with the four agents in carefully defined dosage regimens, and survival was again determined on the tenth postburn day."1.27Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs. ( Bartle, EJ; Bender, EM; Carter, WH; Hansbrough, JF; Mansour, MA; Zapata-Sirvent, RL, 1986)
"Ibuprofen pretreatment (12."1.27Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release. ( Demling, RH; Jin, LJ; Lalonde, C, 1986)

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-199017 (45.95)18.7374
1990's11 (29.73)18.2507
2000's4 (10.81)29.6817
2010's1 (2.70)24.3611
2020's4 (10.81)2.80

Authors

AuthorsStudies
Akgun, AE1
Alkin, M1
Natalwala, I1
Kiely, J1
Kilshaw, A1
McKay, G1
Chu, V1
Phipps, A1
Anwar, MU1
Yarwood, J1
Sandhu, R1
Muthayya, P1
Sloan, B1
Chu, H1
Sen, S1
Wall, SL2
Clarke, DL2
Nauhaus, H1
Allorto, NL2
Tan, Q1
Lin, Z1
Ma, W1
Chen, H1
Wang, L1
Ning, G1
Zhou, X1
Jennes, S1
Saidane, G1
Fauville, JP1
Ledoux, M1
Colinet, B1
Sorkin, LS1
Doom, CM1
Maruyama, KP1
Nanigian, DB1
Alexander, F1
Mathieson, M1
Teoh, KH1
Huval, WV1
Lelcuk, S1
Valeri, CR1
Shepro, D1
Hechtman, HB1
Hansbrough, J1
Peterson, V1
Zapata-Sirvent, R1
Claman, HN1
Ehrlich, HP5
Dong, YL2
Herndon, DN2
Yan, TZ2
Waymack, JP3
Fleming, RY1
Cetinkale, O1
Demir, M1
Sayman, HB1
Ayan, F1
Onsel, C1
Petersen, KL1
Brennum, J1
Dahl, JB1
Sakurai, H1
Traber, LD1
Traber, DL1
Barrow, RE1
Ramirez, RJ1
Zhang, XJ1
Regas, FC1
Wallace, BH1
Caldwell, FT1
Cone, JB1
Grbic, JT1
Mannick, JA1
Gough, DB1
Rodrick, ML1
Rockwell, WB1
Demling, RH7
LaLonde, C7
Wong, C2
Jin, LJ2
Hechtman, H2
West, K3
Zapata-Sirvent, RL1
Hansbrough, JF1
Bender, EM1
Bartle, EJ1
Mansour, MA1
Carter, WH1
Bjornson, AB1
Knippenberg, RW1
Bjornson, HS1
Freeman, TR1
Shelby, J1
Zhu, D1
Katz, A1
Ryan, P1
Demling, R1
MacGarvey, U1
McGrane, WL1
White, ME1
Odessey, R1
Wenger, H1
Lalonde, CC1
Iizuka, Y1
Tanaka, K1

Reviews

1 review available for ibuprofen and Burns

ArticleYear
Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.
    Pain, 1997, Volume: 70, Issue:2-3

    Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cross-Over Studies; Double-Blind

1997

Trials

2 trials available for ibuprofen and Burns

ArticleYear
Pain Management With Topical Ibuprofen in Partial-Thickness Burn Wounds and Effects on Wound Healing: A Prospective Randomized Clinical Study.
    Wound management & prevention, 2023, Volume: 69, Issue:1

    Topics: Burns; Cicatrix; Humans; Ibuprofen; Pain Management; Prospective Studies; Soft Tissue Injuries; Woun

2023
Experimental evaluation of the analgesic effect of ibuprofen on primary and secondary hyperalgesia.
    Pain, 1997, Volume: 70, Issue:2-3

    Topics: Adult; Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cross-Over Studies; Double-Blind

1997

Other Studies

35 other studies available for ibuprofen and Burns

ArticleYear
The Pinderfields hospital pain management protocol for enzymatic debridement of burns wounds.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:2

    Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Conduction; Ane

2020
Pre-attendance analgesia advice for small acute paediatric burns in the British Isles: A National Survey.
    Burns : journal of the International Society for Burn Injuries, 2020, Volume: 46, Issue:6

    Topics: Acetaminophen; Ambulatory Care; Analgesics; Burns; Child; Humans; Ibuprofen; Pain Management; Pain,

2020
Barriers to adequate analgesia in paediatric burns patients.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2020, Sep-30, Volume: 110, Issue:10

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Burns; Child; Child, Preschool; Clinica

2020
Analgesia protocols for burns dressings: Challenges with implementation.
    Burns : journal of the International Society for Burn Injuries, 2019, Volume: 45, Issue:7

    Topics: Academic Medical Centers; Acetaminophen; Analgesics; Anesthetics, Inhalation; Bandages; Burns; Child

2019
Failure of Ibuprofen to prevent progressive dermal ischemia after burning in guinea pigs.
    Burns : journal of the International Society for Burn Injuries, 2002, Volume: 28, Issue:5

    Topics: Animals; Burns; Cyclooxygenase Inhibitors; Dermis; Disease Models, Animal; Guinea Pigs; Ibuprofen; I

2002
Transient selective factor X deficiency in a severely burned child.
    Burns : journal of the International Society for Burn Injuries, 2008, Volume: 34, Issue:7

    Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Surface Area; Burns; Erythrocyt

2008
Secondary hyperalgesia in the rat first degree burn model is independent of spinal cyclooxygenase and nitric oxide synthase.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Behavior, Animal; Burns; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Diltiazem; En

2008
Arachidonic acid metabolites mediate early burn edema.
    The Journal of trauma, 1984, Volume: 24, Issue:8

    Topics: Animals; Body Water; Burns; Calcium Channel Blockers; Capillary Permeability; Chromones; Edema; Ibup

1984
Postburn immunosuppression in an animal model. II. Restoration of cell-mediated immunity by immunomodulating drugs.
    Surgery, 1984, Volume: 95, Issue:3

    Topics: Animals; Burns; Chlorides; Cimetidine; Cyclophosphamide; Dinitrofluorobenzene; Drug Hypersensitivity

1984
Anti-inflammatory drugs in the vascular response to burn injury.
    The Journal of trauma, 1984, Volume: 24, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Burns; Epoprostenol; Hydrocortisone; Ibuprofen

1984
Promotion of vascular patency in dermal burns with ibuprofen.
    The American journal of medicine, 1984, Jul-13, Volume: 77, Issue:1A

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Vessels; Body Fluids; Burns; Fibrinolysis; Freezing; Ib

1984
Blockade of prostaglandin products augments macrophage and neutrophil tumor necrosis factor synthesis in burn injury.
    The Journal of surgical research, 1993, Volume: 54, Issue:5

    Topics: Animals; Burns; Ibuprofen; Lipopolysaccharides; Macrophages; Male; Neutrophils; Prostaglandins; Pros

1993
Effect of ibuprofen on the inflammatory response to surgical wounds.
    The Journal of trauma, 1993, Volume: 35, Issue:3

    Topics: Animals; Burns; Cecum; Dermatologic Surgical Procedures; Ibuprofen; Immune Tolerance; Inflammation;

1993
Effects of allopurinol, ibuprofen and cyclosporin A on local microcirculatory disturbance due to burn injuries.
    Burns : journal of the International Society for Burn Injuries, 1997, Volume: 23, Issue:1

    Topics: Allopurinol; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Burns; Cyclospo

1997
Altered systemic organ blood flow after combined injury with burn and smoke inhalation.
    Shock (Augusta, Ga.), 1998, Volume: 9, Issue:5

    Topics: Animals; Blood Pressure; Body Temperature; Burns; Female; Heart Rate; Hematocrit; Hemodynamics; Ibup

1998
Ibuprofen modulates tissue perfusion in partial-thickness burns.
    Burns : journal of the International Society for Burn Injuries, 2000, Volume: 26, Issue:4

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Burns; Ear,

2000
Elucidating the vascular response to burns with a new rat model.
    The Journal of trauma, 1992, Volume: 32, Issue:5

    Topics: Animals; Blood Vessels; Burns; Ibuprofen; Ischemia; Male; Rats; Rats, Inbred Strains; Regional Blood

1992
Ibuprofen lowers body temperature and metabolic rate of humans with burn injury.
    The Journal of trauma, 1992, Volume: 32, Issue:2

    Topics: Adolescent; Basal Metabolism; Body Temperature; Burns; Calorimetry; Child; Humans; Ibuprofen; Nitrog

1992
The role of prostaglandin E2 in immune suppression following injury.
    Annals of surgery, 1991, Volume: 214, Issue:3

    Topics: Adolescent; Adult; Aged; Burns; Dinoprostone; Endotoxins; Escherichia coli; Female; Humans; Ibuprofe

1991
An ibuprofen-antagonized plasmin inhibitor released by human endothelial cells.
    Experimental and molecular pathology, 1991, Volume: 54, Issue:1

    Topics: Antifibrinolytic Agents; Burns; Cells, Cultured; Cicatrix; Endothelium; Fibrinolysis; Hot Temperatur

1991
Identification and modifications of the pulmonary and systemic inflammatory and biochemical changes caused by a skin burn.
    The Journal of trauma, 1990, Volume: 30, Issue:12 Suppl

    Topics: Allopurinol; Animals; Burns; Deferoxamine; Hemodynamics; Ibuprofen; Lipid Peroxidation; Liver; Lung;

1990
Early postburn lipid peroxidation: effect of ibuprofen and allopurinol.
    Surgery, 1990, Volume: 107, Issue:1

    Topics: Allopurinol; Animals; Burns; Disease Models, Animal; Edema; Ibuprofen; Inflammation; Lipid Peroxidat

1990
Early lung dysfunction after major burns: role of edema and vasoactive mediators.
    The Journal of trauma, 1985, Volume: 25, Issue:10

    Topics: Animals; Burns; Dextrans; Ibuprofen; Isotonic Solutions; Lung; Lung Compliance; Lymphatic System; Pu

1985
The effect of ibuprofen on postburn metabolic and immunologic function.
    The Journal of surgical research, 1989, Volume: 46, Issue:2

    Topics: Animals; Burns; Complement C3; Ibuprofen; Immunoglobulin G; Pseudomonas Infections; Rats; Rats, Inbr

1989
Postburn immunosuppression in an animal model. IV. Improved resistance to septic challenge with immunomodulating drugs.
    Surgery, 1986, Volume: 99, Issue:1

    Topics: Animals; Anti-Infective Agents, Local; Burns; Cerium; Cimetidine; Cyclophosphamide; Dose-Response Re

1986
Nonsteroidal anti-inflammatory drugs correct the bactericidal defect of polymorphonuclear leukocytes in a guinea pig model of thermal injury.
    The Journal of infectious diseases, 1988, Volume: 157, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Bactericidal A

1988
Effect of anti-PGE antibody on cell-mediated immune response in thermally injured mice.
    The Journal of trauma, 1988, Volume: 28, Issue:2

    Topics: Animals; Antibodies; Burns; Graft vs Host Reaction; Host vs Graft Reaction; Ibuprofen; Immunity, Cel

1988
Early pulmonary and hemodynamic effects of a chest wall burn (effect of ibuprofen).
    Surgery, 1988, Volume: 104, Issue:1

    Topics: Animals; Burns; Cardiac Output; Central Venous Pressure; Fluid Therapy; Hemodynamics; Humans; Ibupro

1988
Topical ibuprofen decreases thromboxane release from the endotoxin-stimulated burn wound.
    The Journal of trauma, 1986, Volume: 26, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Topical; Animals; Blood Pressure; Burns; Endotoxins; E

1986
Ibuprofen as an antagonist of inhibitors of fibrinolysis in wound fluid.
    Thrombosis research, 1987, Jan-01, Volume: 45, Issue:1

    Topics: Animals; Antifibrinolytic Agents; Burns; Extracellular Space; Fibrin; Fibrinolysis; Ibuprofen; Male;

1987
Topical ibuprofen decreases early postburn edema.
    Surgery, 1987, Volume: 102, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Administration, Topical; Animals; Burns; Edema; Ibuprofen; Lymph; Pros

1987
Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 61, Issue:1

    Topics: Anesthesia; Animals; Burns; Free Radicals; Ibuprofen; Lung; Oxygen; Postmortem Changes; Prostaglandi

1986
Effect of inhibitors of proteolysis and arachidonic acid metabolism on burn-induced protein breakdown.
    Metabolism: clinical and experimental, 1985, Volume: 34, Issue:7

    Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Burns; Hindlimb; Ibuprofen; In Vitro Techniqu

1985
Endotoxin-induced prostanoid production by the burn wound can cause distant lung dysfunction.
    Surgery, 1986, Volume: 99, Issue:4

    Topics: Animals; Burns; Endotoxins; Hemodynamics; Ibuprofen; Injections, Intravenous; Lung Diseases; Lymph;

1986
][A new method for screening of analgesics applied to heat induced inflammatory pain].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1974, Volume: 70, Issue:5

    Topics: Aminopyrine; Analgesics; Animals; Aspirin; Burns; Drug Evaluation, Preclinical; Flufenamic Acid; Hab

1974