Page last updated: 2024-10-28

ibuprofen and Breast Cancer

ibuprofen has been researched along with Breast Cancer in 33 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients."7.83Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence. ( Ahern, TP; Christiansen, P; Cronin-Fenton, DP; Ejlertsen, B; Heide-Jørgensen, U; Lash, TL; Sørensen, HT, 2016)
"The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m-pentavalent dimercaptosuccinic acid (99mTc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia."7.76Ibuprofen induces reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA uptake in severe epithelial breast hyperplasia without atypia. ( Antsaklis, A; Archontaki, A; Dimitrakakis, K; Fothiadaki, A; Karianos, T; Marinopoulos, S; Papantoniou, V; Sotiropoulou, E; Sotiropoulou, M; Syrgiannis, K; Tsaroucha, A; Tsiouris, S; Valsamaki, P, 2010)
" Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model."5.62Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021)
"Ibuprofen was not effective in the comet assay but showed a significant reduction in MN frequency, with the nano formulation being more effective."5.48Aspirin and ibuprofen, in bulk and nanoforms: Effects on DNA damage in peripheral lymphocytes from breast cancer patients and healthy individuals. ( Anderson, D; Baumgartner, A; Dandah, O; Isreb, M; Linforth, R; Najafzadeh, M; Tait, C, 2018)
"Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical variables known to impact disease outcomes."5.48Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. ( Betts, CB; Borges, VF; Coussens, LM; Guo, Q; Jindal, S; Martinson, HA; Pennock, ND; Schedin, P; Tsujikawa, T, 2018)
"P-I is safe and effective against breast cancer."5.38Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. ( Huang, L; Komninou, D; Mackenzie, GG; Rigas, B; Rowehl, LM; Sun, Y; Vrankova, K, 2012)
"Studies that examined the association between risk of breast cancer and use of NSAIDs, including aspirin and ibuprofen, that were published between January 1, 1966, and July 1, 2008, were identified using Medline, EMBASE, and other databases."4.84Breast cancer and use of nonsteroidal anti-inflammatory drugs: a meta-analysis. ( Etminan, M; Regueira-Méndez, C; Takkouche, B, 2008)
"Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients."3.83Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence. ( Ahern, TP; Christiansen, P; Cronin-Fenton, DP; Ejlertsen, B; Heide-Jørgensen, U; Lash, TL; Sørensen, HT, 2016)
" To overcome this issue, in this work we synthesized biocompatible micellar nanocarriers composed of amphiphilic chitosan to deliver ibuprofen into breast cancer cells and evaluate its anti-tumor activity, while avoiding side-effects."3.80Synthesis and characterization of micelles as carriers of non-steroidal anti-inflammatory drugs (NSAID) for application in breast cancer therapy. ( Correia, IJ; Costa, E; Gaspar, VM; Marques, JG; Paquete, CM, 2014)
"The purpose of this study was to investigate if ibuprofen intake can influence mammary uptake of the proliferation-seeking radiotracer technetium 99m-pentavalent dimercaptosuccinic acid (99mTc-(V)DMSA) in women with severe epithelial and atypical epithelial breast hyperplasia."3.76Ibuprofen induces reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA uptake in severe epithelial breast hyperplasia without atypia. ( Antsaklis, A; Archontaki, A; Dimitrakakis, K; Fothiadaki, A; Karianos, T; Marinopoulos, S; Papantoniou, V; Sotiropoulou, E; Sotiropoulou, M; Syrgiannis, K; Tsaroucha, A; Tsiouris, S; Valsamaki, P, 2010)
"From 2000 to 2002, mailed questionnaires were used to obtain information on aspirin, ibuprofen, and other NSAID use and subsequent breast cancer events."3.74NSAIDs and breast cancer recurrence in a prospective cohort study. ( Caan, B; Habel, LA; Kwan, ML; Slattery, ML, 2007)
"Epidemiologic studies of the association between nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, and breast cancer risk have yielded inconsistent results."3.73Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status. ( Anton-Culver, H; Bernstein, L; Deapen, D; Horn-Ross, PL; Marshall, SF; Mohrenweiser, H; Peel, D; Pinder, R; Purdie, DM; Reynolds, P; Ross, RK; Stram, D; West, D; Wright, WE; Ziogas, A, 2005)
"We analyzed data from the prospective Women's Health Initiative (WHI) Observational Study to examine the effects of regular use of aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer risk."3.72Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. ( Anderson, G; Ascenseo, JL; Chlebowski, RT; Frid, DJ; Harris, RE; Jackson, RD; Loar, A; McTiernan, A; Rodabough, RJ; White, E, 2003)
"Previous studies have shown that the prostaglandin synthesis inhibitor indomethacin reduced osteolysis produced by the experimental VX2 carcinoma, probably by inhibiting the stimulation of osteoclasts by prostaglandin E2."3.66The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis. ( Galasko, CS; Lacey, E; Rushton, S; Samuel, AW, 1980)
"In addition to providing acute postoperative pain relief, preoperative PVB seems to reduce the prevalence of chronic pain 1 yr after breast cancer surgery."2.72Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. ( Bachmann, MS; Kairaluoma, PM; Pere, PJ; Rosenberg, PH, 2006)
"A slight reduction of breast cancer by taking aspirin and ibuprofen was both observed with pooled RR of 0."2.45Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis. ( Hu, FL; Li, DD; Li, X; Li, XW; Wang, F; Zhang, WC; Zhao, YS; Zhu, S, 2009)
" Herein, the impacts of metformin alone and in combination with cimetidine/ibuprofen on some Th1- and regulatory T (Treg) cell-related parameters were evaluated using a breast cancer (BC) model."1.62Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model. ( Hassan, ZM; Jafarzadeh, A; Khorramdelazad, H; Masoumi, J; Nemati, M; Oladpour, O; Rezayati, MT; Taghipour, F; Taghipour, Z, 2021)
"Ibuprofen was not effective in the comet assay but showed a significant reduction in MN frequency, with the nano formulation being more effective."1.48Aspirin and ibuprofen, in bulk and nanoforms: Effects on DNA damage in peripheral lymphocytes from breast cancer patients and healthy individuals. ( Anderson, D; Baumgartner, A; Dandah, O; Isreb, M; Linforth, R; Najafzadeh, M; Tait, C, 2018)
"Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical variables known to impact disease outcomes."1.48Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer. ( Betts, CB; Borges, VF; Coussens, LM; Guo, Q; Jindal, S; Martinson, HA; Pennock, ND; Schedin, P; Tsujikawa, T, 2018)
"P-I is safe and effective against breast cancer."1.38Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system. ( Huang, L; Komninou, D; Mackenzie, GG; Rigas, B; Rowehl, LM; Sun, Y; Vrankova, K, 2012)
"The prognosis of breast cancer in young women is influenced by reproductive history."1.37Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2. ( Borges, VF; Conklin, MW; Eliceiri, KW; Keely, PJ; Lyons, TR; Marusyk, A; O'Brien, J; Schedin, P; Tan, AC, 2011)
"and compound 7c exhibit good anticancer activity against ovary (IGR-OV-1), breast (MCF-7) and CNS(SF-295) human cancer cell lines."1.36Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives. ( Agrawal, SK; Rani, R; Roy, P; Saxena, AK; Singh, J; Sondhi, SM, 2010)
"The relative risk of breast cancer was reduced in women using these compounds at least 3 times per week for > or = 1 year [odds ratio (OR) = 0."1.29Nonsteroidal antiinflammatory drugs and breast cancer. ( Farrar, WB; Harris, RE; Namboodiri, KK, 1996)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.06)18.7374
1990's2 (6.06)18.2507
2000's8 (24.24)29.6817
2010's17 (51.52)24.3611
2020's4 (12.12)2.80

Authors

AuthorsStudies
Sondhi, SM1
Rani, R1
Singh, J1
Roy, P1
Agrawal, SK1
Saxena, AK1
Liu, W2
Zhou, J2
Bensdorf, K1
Zhang, H2
Liu, H1
Wang, Y2
Qian, H2
Zhang, Y1
Wellner, A1
Rubner, G1
Huang, W2
Guo, C1
Gust, R3
Zhang, T1
Zhu, H1
Taghipour, F1
Oladpour, O1
Rezayati, MT1
Khorramdelazad, H1
Nemati, M1
Taghipour, Z1
Masoumi, J1
Hassan, ZM1
Jafarzadeh, A1
Predarska, I1
Saoud, M1
Morgan, I1
Eichhorn, T1
Kaluđerović, GN1
Hey-Hawkins, E1
Thiruchenthooran, V1
Świtalska, M1
Bonilla, L1
Espina, M1
García, ML1
Wietrzyk, J1
Sánchez-López, E1
Gliszczyńska, A1
Chai, Z1
Teng, C1
Yang, L1
Ren, L1
Yuan, Z1
Xu, S1
Cheng, M1
Yan, Z1
Qin, C1
Han, X1
Yin, L1
Tran, BN1
Nguyen, HT1
Kim, JO1
Yong, CS1
Nguyen, CN1
Dandah, O1
Najafzadeh, M1
Isreb, M1
Linforth, R1
Tait, C1
Baumgartner, A1
Anderson, D1
Sahin, A1
Spiroux, F1
Guedon, I1
Arslan, FB1
Sarcan, ET1
Ozkan, T1
Colak, N1
Yuksel, S1
Ozdemir, S1
Ozdemir, B1
Akbas, S1
Ultav, G1
Aktas, Y1
Capan, Y1
Pennock, ND1
Martinson, HA1
Guo, Q1
Betts, CB1
Jindal, S1
Tsujikawa, T1
Coussens, LM1
Borges, VF2
Schedin, P2
Marques, JG1
Gaspar, VM1
Costa, E1
Paquete, CM1
Correia, IJ1
Cronin-Fenton, DP1
Heide-Jørgensen, U1
Ahern, TP1
Lash, TL1
Christiansen, P1
Ejlertsen, B1
Sørensen, HT1
Kopp, TI1
Jensen, DM1
Ravn-Haren, G1
Cohen, A1
Sommer, HM1
Dragsted, LO1
Tjonneland, A1
Hougaard, DM1
Vogel, U1
Takkouche, B1
Regueira-Méndez, C1
Etminan, M1
Zhao, YS1
Zhu, S1
Li, XW1
Wang, F1
Hu, FL1
Li, DD1
Zhang, WC1
Li, X1
Brasky, TM2
Bonner, MR2
Moysich, KB2
Ochs-Balcom, HM1
Marian, C2
Ambrosone, CB2
Nie, J2
Tao, MH2
Edge, SB2
Trevisan, M2
Shields, PG2
Freudenheim, JL2
Papantoniou, V1
Tsaroucha, A1
Valsamaki, P1
Tsiouris, S1
Sotiropoulou, E1
Karianos, T1
Marinopoulos, S1
Fothiadaki, A1
Sotiropoulou, M1
Archontaki, A1
Syrgiannis, K1
Dimitrakakis, K1
Antsaklis, A1
Kallakury, BV1
Goerlitz, DS1
Lyons, TR1
O'Brien, J1
Conklin, MW1
Keely, PJ1
Eliceiri, KW1
Marusyk, A1
Tan, AC1
Mattheolabakis, G1
Nie, T1
Constantinides, PP1
Rigas, B2
Sun, Y1
Rowehl, LM1
Huang, L1
Mackenzie, GG1
Vrankova, K1
Komninou, D1
Mitchell, A1
McCrea, P1
Inglis, K1
Porter, G1
Robb-Nicholson, C1
Harris, RE2
Chlebowski, RT1
Jackson, RD1
Frid, DJ1
Ascenseo, JL1
Anderson, G1
Loar, A1
Rodabough, RJ1
White, E1
McTiernan, A1
Marshall, SF1
Bernstein, L1
Anton-Culver, H1
Deapen, D1
Horn-Ross, PL1
Mohrenweiser, H1
Peel, D1
Pinder, R1
Purdie, DM1
Reynolds, P1
Stram, D1
West, D1
Wright, WE1
Ziogas, A1
Ross, RK1
Kairaluoma, PM1
Bachmann, MS1
Rosenberg, PH1
Pere, PJ1
Banekovich, C1
Ott, I1
Koch, T1
Matuszczak, B1
Kwan, ML1
Habel, LA1
Slattery, ML1
Caan, B1
Galasko, CS1
Samuel, AW1
Rushton, S1
Lacey, E1
Namboodiri, KK1
Farrar, WB1
Cameron, DJ1
O'Brien, P1
Majeski, JA1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Alcohol-related Breast Cancer in Postmenopausal Women - Effect of PPARG2pro12ala Polymorphism on Female Sex-hormone Levels and Interaction With Alcohol Consumption and NSAID Usage[NCT02463383]Early Phase 125 participants (Actual)Interventional2013-09-30Completed
Post-operative Analgesia in Elective, Soft-tissue Hand Surgery: A Randomized, Double Blind Comparison of Acetaminophen/Ibuprofen Versus Acetaminophen/Hydrocodone[NCT02029235]Phase 472 participants (Actual)Interventional2015-02-10Terminated (stopped due to Early termination due to slower than anticipated recruitment.)
[NCT00000611]Phase 30 participants InterventionalCompleted
Analgesia Efficacy of Pre-operative and Post-operative PEC I/II Block for Bilateral Mastectomy With Reconstruction[NCT03653988]35 participants (Actual)Interventional2019-03-12Completed
Comparison Between Serratus Anterior Plane Block, and Transversus Thoracic Plane Block Combined With Serratus Anterior Plane Block, for the Management of Post-mastecomy Pain.[NCT04375111]54 participants (Actual)Interventional2021-06-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Efficacy Comparison of Pain Intensity Level

"Subjects asked to fill out a patient diary recording their pain intensity level (on 100mm Visual Analog Scale) prior to taking study medication every 4 hours.~The daily average pain intensity levels are reported as a score on a scale of 0-100, with higher score meaning worse outcome.~The daily average pain levels were assessed daily for 1 week post-operatively, then compared between the 2 groups using a two-group Student's t-test." (NCT02029235)
Timeframe: 1 week post-operatively

,
Interventionscore on a scale (0-100, higher = worse) (Mean)
Daily average pain intensity level on PostOp Day 1Daily average pain intensity level on PostOp Day 2Daily average pain intensity level on PostOp Day 3Daily average pain intensity levelon PostOp Day 4Daily average pain intensity level on PostOp Day 5Daily average pain intensity level on PostOp Day 6Daily average pain intensity level on PostOp Day 7
Acetaminophen/Hydrocodone (AH) Group24.0730.1622.1118.5316.6113.5813.00
Acetaminophen/Ibuprofen (AIBU) Group22.1722.2215.6713.1714.0313.4412.67

Efficacy Comparison of Pain Relief

"Subjects asked to fill out a patient diary recording their pain relief (on a Likert scale) one hour after taking study medication every 4 hours.~Daily average pain relief scores are reported as a score on a scale of 0-3, with higher score meaning better outcome.~The daily average pain relief scores were assessed daily for 1 week post-operatively, then compared using generalized linear mixed-effects models" (NCT02029235)
Timeframe: 1 week postoperatively

,
Interventionscore on a scale (0-3, higher = better) (Mean)
Daily average pain relief on PostOp Day 1Daily average pain relief on PostOp Day 2Daily average pain relief on PostOp Day 3Daily average pain relief on PostOp Day 4Daily average pain relief on PostOp Day 5Daily average pain relief on PostOp Day 6Daily average pain relief on PostOp Day 7
Acetaminophen/Hydrocodone (AH) Group1.531.762.332.462.542.842.88
Acetaminophen/Ibuprofen (AIBU) Group1.842.272.632.912.882.872.96

Reviews

2 reviews available for ibuprofen and Breast Cancer

ArticleYear
Breast cancer and use of nonsteroidal anti-inflammatory drugs: a meta-analysis.
    Journal of the National Cancer Institute, 2008, Oct-15, Volume: 100, Issue:20

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Case-Control Studies; Cohort Stu

2008
Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis.
    Breast cancer research and treatment, 2009, Volume: 117, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Female; Humans; Ibuprofen; Risk

2009

Trials

4 trials available for ibuprofen and Breast Cancer

ArticleYear
Alcohol-related breast cancer in postmenopausal women - effect of CYP19A1, PPARG and PPARGC1A polymorphisms on female sex-hormone levels and interaction with alcohol consumption and NSAID usage in a nested case-control study and a randomised controlled tr
    BMC cancer, 2016, Apr-21, Volume: 16

    Topics: Adult; Alcohol Drinking; Alcohols; Anti-Inflammatory Agents, Non-Steroidal; Aromatase; Breast Neopla

2016
Genetic variants in COX-2, non-steroidal anti-inflammatory drugs, and breast cancer risk: the Western New York Exposures and Breast Cancer (WEB) Study.
    Breast cancer research and treatment, 2011, Volume: 126, Issue:1

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast; Breast Neoplasms; Case-Contro

2011
A randomized, controlled trial comparing acetaminophen plus ibuprofen versus acetaminophen plus codeine plus caffeine (Tylenol 3) after outpatient breast surgery.
    Annals of surgical oncology, 2012, Volume: 19, Issue:12

    Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Breast Neoplasms; Ca

2012
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006
Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery.
    Anesthesia and analgesia, 2006, Volume: 103, Issue:3

    Topics: Acetaminophen; Analgesia, Epidural; Breast Neoplasms; Bupivacaine; Codeine; Follow-Up Studies; Human

2006

Other Studies

27 other studies available for ibuprofen and Breast Cancer

ArticleYear
Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives.
    Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor;

2010
Investigations on cytotoxicity and anti-inflammatory potency of licofelone derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell S

2011
Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
    Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Biological Assay; Breast Neoplasms; Cell L

2012
Modulatory Effects of Metformin Alone and in Combination with Cimetidine and Ibuprofen on T Cell-related Parameters in a Breast Cancer Model.
    Iranian journal of allergy, asthma, and immunology, 2021, Sep-28, Volume: 20, Issue:5

    Topics: Animals; Biomarkers; Breast Neoplasms; Cell Line, Tumor; Cimetidine; Disease Models, Animal; Female;

2021
Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line.
    Dalton transactions (Cambridge, England : 2003), 2022, Jan-17, Volume: 51, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclooxygenase

2022
Novel Strategies against Cancer: Dexibuprofen-Loaded Nanostructured Lipid Carriers.
    International journal of molecular sciences, 2022, Sep-25, Volume: 23, Issue:19

    Topics: Breast Neoplasms; Drug Carriers; Humans; Ibuprofen; Lipids; Male; Nanostructures; Particle Size; Pol

2022
Doxorubicin delivered by redox-responsive Hyaluronic Acid-Ibuprofen prodrug micelles for treatment of metastatic breast cancer.
    Carbohydrate polymers, 2020, Oct-01, Volume: 245

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Movement; Cell Proliferation; Disease M

2020
Combination of a chemopreventive agent and paclitaxel in CD44-targeted hybrid nanoparticles for breast cancer treatment.
    Archives of pharmacal research, 2017, Volume: 40, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell P

2017
Aspirin and ibuprofen, in bulk and nanoforms: Effects on DNA damage in peripheral lymphocytes from breast cancer patients and healthy individuals.
    Mutation research. Genetic toxicology and environmental mutagenesis, 2018, Volume: 826

    Topics: Adult; Aged; Aged, 80 and over; Aspirin; Breast Neoplasms; Case-Control Studies; Comet Assay; DNA Da

2018
Using PVA and TPGS as combined emulsifier in nanoprecipitation method improves characteristics and anticancer activity of ibuprofen loaded PLGA nanoparticles.
    Die Pharmazie, 2017, Sep-01, Volume: 72, Issue:9

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Caco-2 Cells; Chemistry, Pharmaceu

2017
Ibuprofen supports macrophage differentiation, T cell recruitment, and tumor suppression in a model of postpartum breast cancer.
    Journal for immunotherapy of cancer, 2018, 10-01, Volume: 6, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Differentiation; Female; Hu

2018
Synthesis and characterization of micelles as carriers of non-steroidal anti-inflammatory drugs (NSAID) for application in breast cancer therapy.
    Colloids and surfaces. B, Biointerfaces, 2014, Jan-01, Volume: 113

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cel

2014
Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence.
    Epidemiology (Cambridge, Mass.), 2016, Volume: 27, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms;

2016
Ibuprofen induces reduction of the proliferation-seeking radiotracer 99mTc-(V)DMSA uptake in severe epithelial breast hyperplasia without atypia.
    Molecular imaging, 2010, Volume: 9, Issue:5

    Topics: Breast Neoplasms; Female; Humans; Hyperplasia; Ibuprofen; Mammography; Middle Aged; Prospective Stud

2010
Non-steroidal anti-inflammatory drugs (NSAIDs) and breast cancer risk: differences by molecular subtype.
    Cancer causes & control : CCC, 2011, Volume: 22, Issue:7

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biomarkers, Tumor; Breast Neoplasms;

2011
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
    Nature medicine, 2011, Aug-07, Volume: 17, Issue:9

    Topics: Analysis of Variance; Animals; Blotting, Western; Breast Neoplasms; Carcinoma, Ductal; Celecoxib; Ce

2011
Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): preparation, characterization, and in vitro/in vivo evaluation.
    Pharmaceutical research, 2012, Volume: 29, Issue:6

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chemistry, P

2012
Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system.
    Breast cancer research : BCR, 2012, Jan-31, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; Cycl

2012
By the way, doctor. I recently read that anti-inflammatory drugs reduce the risk of breast cancer. Is this true? Can you tell me anything about this?
    Harvard women's health watch, 2003, Volume: 11, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cyclooxygenase Inhibitors; Femal

2003
Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative.
    Cancer research, 2003, Sep-15, Volume: 63, Issue:18

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; Cohort Studie

2003
Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status.
    Journal of the National Cancer Institute, 2005, Jun-01, Volume: 97, Issue:11

    Topics: Acetaminophen; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bre

2005
Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.
    Bioorganic & medicinal chemistry letters, 2007, Feb-01, Volume: 17, Issue:3

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; C

2007
NSAIDs and breast cancer recurrence in a prospective cohort study.
    Cancer causes & control : CCC, 2007, Volume: 18, Issue:6

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms; California; Chemopreventio

2007
The effect of prostaglandin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis.
    The British journal of surgery, 1980, Volume: 67, Issue:7

    Topics: Animals; Bone Resorption; Breast Neoplasms; Culture Techniques; Diphosphonates; Flurbiprofen; Humans

1980
Regular NSAID use appears to reduce breast cancer severity.
    Oncology (Williston Park, N.Y.), 1996, Volume: 10, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Chemoprevention; Female; Humans; Ibuprofe

1996
Nonsteroidal antiinflammatory drugs and breast cancer.
    Epidemiology (Cambridge, Mass.), 1996, Volume: 7, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Breast Neoplasms;

1996
Effects of in vivo treatment with ibuprofen on macrophage function in breast and colon cancer patients.
    Journal of clinical & laboratory immunology, 1986, Volume: 20, Issue:1

    Topics: Breast Neoplasms; Cell Line; Cells, Cultured; Centrifugation, Density Gradient; Colonic Neoplasms; C

1986