ibuprofen has been researched along with Brain Ischemia in 13 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 7.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| "Ibuprofen provides neuroprotection through glial cells against excitotoxic neuronal injury caused by glutamatergic excitotoxicity after cerebral ischemia as demonstrated by reduced neuronal cell death in mixed cell cultures." | 7.76 | Ibuprofen for neuroprotection after cerebral ischemia. ( Iwata, Y; Jonas, RA; Nicole, O; Okamura, T; Zurakowski, D, 2010) |
| " Accordingly, the effect of cyclooxygenase inhibition by ibuprofen on post-ischemic eicosanoid production and delayed neuronal death was evaluated in Wistar-Kyoto rats subjected to incomplete forebrain ischemia." | 7.68 | Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats. ( Cole, DJ; Drummond, JC; Kalkman, CJ; Patel, PM; Sano, T; Yaksh, TL, 1993) |
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 3.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| " High-dose ibuprofen and diclofenac were associated with increased risk of ischemic stroke [hazard ratio 2·15 (95% confidence interval 1·66-2·79) and 2·37 (confidence interval 1·99-2·81), respectively]." | 3.80 | Use of nonsteroidal anti-inflammatory drugs among healthy people and specific cerebrovascular safety. ( Andersson, C; Fosbøl, EL; Gislason, GH; Kober, L; Olesen, JB; Olsen, AM; Torp-Pedersen, C, 2014) |
| "Ibuprofen provides neuroprotection through glial cells against excitotoxic neuronal injury caused by glutamatergic excitotoxicity after cerebral ischemia as demonstrated by reduced neuronal cell death in mixed cell cultures." | 3.76 | Ibuprofen for neuroprotection after cerebral ischemia. ( Iwata, Y; Jonas, RA; Nicole, O; Okamura, T; Zurakowski, D, 2010) |
| " Accordingly, the effect of cyclooxygenase inhibition by ibuprofen on post-ischemic eicosanoid production and delayed neuronal death was evaluated in Wistar-Kyoto rats subjected to incomplete forebrain ischemia." | 3.68 | Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats. ( Cole, DJ; Drummond, JC; Kalkman, CJ; Patel, PM; Sano, T; Yaksh, TL, 1993) |
| "Rats treated with ibuprofen after transient forebrain ischemia displayed long-lasting protection of CA1 hippocampal neurons." | 1.33 | Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. ( Cho, BP; Cho, S; Cruz, MO; Joh, TH; Park, EM; Volpe, BT, 2005) |
| "Brain ischemia is associated with an acute release of pro-inflammatory cytokines, notably TNF-alpha and IL-6 and failure of the blood-brain barrier." | 1.33 | Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model. ( Cunningham, E; Hossain, M; Janigro, D; Krizanac-Bengez, L; Mayberg, MR; Parkinson, FE; Ponnampalam, S, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gonzalez-Valcarcel, J | 1 |
| Sissani, L | 1 |
| Labreuche, J | 1 |
| Bousser, MG | 1 |
| Chamorro, A | 1 |
| Fisher, M | 1 |
| Ford, I | 1 |
| Fox, KM | 1 |
| Hennerici, MG | 1 |
| Mattle, HP | 1 |
| Rothwell, PM | 1 |
| Steg, PG | 1 |
| Vicaut, E | 1 |
| Amarenco, P | 1 |
| Iannuccelli, C | 1 |
| Di Franco, M | 1 |
| Pulcinelli, FM | 1 |
| Iwata, Y | 1 |
| Nicole, O | 1 |
| Zurakowski, D | 1 |
| Okamura, T | 1 |
| Jonas, RA | 1 |
| Fosbøl, EL | 1 |
| Olsen, AM | 1 |
| Olesen, JB | 1 |
| Andersson, C | 1 |
| Kober, L | 1 |
| Torp-Pedersen, C | 1 |
| Gislason, GH | 1 |
| Park, EM | 1 |
| Cho, BP | 1 |
| Volpe, BT | 1 |
| Cruz, MO | 1 |
| Joh, TH | 1 |
| Cho, S | 1 |
| Krizanac-Bengez, L | 1 |
| Mayberg, MR | 1 |
| Cunningham, E | 1 |
| Hossain, M | 1 |
| Ponnampalam, S | 1 |
| Parkinson, FE | 1 |
| Janigro, D | 1 |
| Patel, PM | 2 |
| Drummond, JC | 2 |
| Sano, T | 1 |
| Cole, DJ | 2 |
| Kalkman, CJ | 1 |
| Yaksh, TL | 1 |
| Reynolds, L | 1 |
| Marcantonio, S | 1 |
| Hall, ED | 1 |
| Andrus, PK | 1 |
| Althaus, JS | 1 |
| VonVoigtlander, PF | 1 |
| Sacco, S | 1 |
| Agnello, D | 1 |
| Sottocorno, M | 1 |
| Lozza, G | 1 |
| Monopoli, A | 1 |
| Villa, P | 1 |
| Ghezzi, P | 1 |
| Joseph, R | 1 |
| Han, E | 1 |
| Tsering, C | 1 |
| Grunfeld, S | 1 |
| Welch, KM | 1 |
| O'Shaughnessy, CT | 1 |
| Rothwell, NJ | 1 |
| Shrewsbury-Gee, J | 1 |
| Kuhn, JE | 1 |
| Steimle, CN | 1 |
| Zelenock, GB | 1 |
| D'Alecy, LG | 1 |
13 other studies available for ibuprofen and Brain Ischemia
| Article | Year |
|---|---|
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo | 2016 |
Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke".
Topics: Acetaminophen; Brain Ischemia; Hemorrhage; Humans; Ibuprofen; Stroke | 2016 |
Ibuprofen for neuroprotection after cerebral ischemia.
Topics: Animals; Astrocytes; Brain Ischemia; Cell Death; Cells, Cultured; Excitatory Amino Acid Agonists; Ib | 2010 |
Use of nonsteroidal anti-inflammatory drugs among healthy people and specific cerebrovascular safety.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Cohort Studies; Denmark; Diclofenac; | 2014 |
Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain Isc | 2005 |
Loss of shear stress induces leukocyte-mediated cytokine release and blood-brain barrier failure in dynamic in vitro blood-brain barrier model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Blood-Brain Barrier; Brain Ischemia | 2006 |
Effect of ibuprofen on regional eicosanoid production and neuronal injury after forebrain ischemia in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Body Weight; Brain Ischemia; Caudate Nucleus; Cell Death; Dia | 1993 |
Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Cyclooxygenase Inhibitors; Hyperten | 1993 |
Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain.
Topics: Animals; Brain; Brain Ischemia; Cerebral Cortex; Cytochrome P-450 Enzyme Inhibitors; Dose-Response R | 1993 |
Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Brain; Brain Ischemia; En | 1998 |
Platelet activity and stroke severity.
Topics: Aged; Aspirin; Blood Platelets; Brain Ischemia; Calcium; Cardiovascular Agents; Collagen; Disease Su | 1992 |
Sympathetically mediated hypermetabolic response to cerebral ischemia in the rat.
Topics: Adipose Tissue, Brown; Animals; Body Temperature; Brain Ischemia; Cerebral Arteries; Ibuprofen; Male | 1990 |
Ibuprofen improves survival and neurologic outcome after resuscitation from cardiac arrest.
Topics: Animals; Brain Ischemia; Dogs; Heart Arrest; Ibuprofen; Inflammation; Random Allocation; Resuscitati | 1986 |