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ibuprofen and Brain Inflammation

ibuprofen has been researched along with Brain Inflammation in 15 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors."8.02The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021)
"A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)."5.27Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986)
"The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors."4.02The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021)
"In this study we examined the protective effects of icariin, a flavonol isolated from Herba epimedii, on learning and memory in a rat model with brain inflammation induced by lipopolysaccharide (LPS)."3.76Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats. ( Gong, Q; Guo, J; Li, F; Lu, Y; Shi, J; Wu, Q, 2010)
"Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has been reported to reduce the risk of developing Alzheimer's disease (AD)."1.38No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease. ( Bayer, TA; Bulic, B; Demuth, HU; Hahn, S; Hillmann, A; Hoffmann, T; Schilling, S; Schneider-Axmann, T; Weggen, S; Wirths, O, 2012)
"Ibuprofen was found to down-regulate the TBI-induced inflammatory response."1.38Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury. ( Forsberg-Nilsson, K; Hånell, A; Hillered, L; Holmqvist, K; Marklund, N; Wallenquist, U, 2012)
" We examined the possibility that concurrent blockade of free radicals and prostaglandin E(2) (PGE(2))-mediated inflammation might constitute a safe and effective therapeutic approach to ALS."1.38Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis. ( Cho, W; Gwag, BJ; Im, DS; Lee, JH; Lee, JK; Lee, YA; Lee, YB; Shin, JH; Springer, JE; Yun, BS, 2012)
"The neuronopathic forms of Gaucher's disease are characterized by severe neuronal loss, astrocytosis and microglial proliferation, but the cellular and molecular pathways causing these changes are not known."1.38Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease. ( Biton, I; Eilam, R; Farfel-Becker, T; Futerman, AH; Vitner, EB, 2012)
"Ibuprofen treatment also prevented the HI-induced loss O4- and O1-positive oligodendrocyte progenitor cells and myelin basic protein (MBP)-positive myelin content one week after P3 HI."1.37Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia-ischemia in the immature rodent brain. ( Buller, KM; Carty, ML; Colditz, PB; Gobe, G; Reinebrant, HE; Wixey, JA, 2011)
"A model of brain inflammation has recently been developed in mice using intraventricular injection of carrageenan (CAR)."1.27Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation. ( Ellis, EF; Gamache, DA, 1986)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's0 (0.00)18.2507
2000's2 (13.33)29.6817
2010's11 (73.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Salmani, H1
Hosseini, M1
Baghcheghi, Y1
Samadi-Noshahr, Z1
Corwin, C1
Nikolopoulou, A1
Pan, AL1
Nunez-Santos, M1
Vallabhajosula, S1
Serrano, P1
Babich, J1
Figueiredo-Pereira, ME1
Meunier, J1
Borjini, N1
Gillis, C1
Villard, V1
Maurice, T1
Llorens-Martín, M1
Jurado-Arjona, J1
Fuster-Matanzo, A1
Hernández, F1
Rábano, A1
Ávila, J1
Tyagi, E1
Agrawal, R1
Nath, C2
Shukla, R2
Guo, J1
Li, F1
Wu, Q1
Gong, Q1
Lu, Y1
Shi, J1
Carty, ML1
Wixey, JA1
Reinebrant, HE1
Gobe, G1
Colditz, PB1
Buller, KM1
Hillmann, A1
Hahn, S1
Schilling, S1
Hoffmann, T1
Demuth, HU1
Bulic, B1
Schneider-Axmann, T1
Bayer, TA1
Weggen, S1
Wirths, O1
Wallenquist, U1
Holmqvist, K1
Hånell, A1
Marklund, N1
Hillered, L1
Forsberg-Nilsson, K1
Shin, JH1
Lee, YA1
Lee, JK1
Lee, YB1
Cho, W1
Im, DS1
Lee, JH1
Yun, BS1
Springer, JE1
Gwag, BJ1
Vitner, EB1
Farfel-Becker, T1
Eilam, R1
Biton, I1
Futerman, AH1
Cao, T1
Thomas, TC1
Ziebell, JM1
Pauly, JR1
Lifshitz, J1
Rai, S1
Kamat, PK1
Vlad, SC1
Miller, DR1
Kowall, NW1
Felson, DT1
Gamache, DA1
Ellis, EF1

Other Studies

15 other studies available for ibuprofen and Brain Inflammation

ArticleYear
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Animal;

2021
Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets.
    Journal of neuroinflammation, 2018, Sep-20, Volume: 15, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Disease Models, Animal; Enc

2018
Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.
    Journal of Alzheimer's disease : JAD, 2015, Volume: 44, Issue:2

    Topics: Adenine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Age

2015
Peripherally triggered and GSK-3β-driven brain inflammation differentially skew adult hippocampal neurogenesis, behavioral pattern separation and microglial activation in response to ibuprofen.
    Translational psychiatry, 2014, Oct-14, Volume: 4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Disease Models, Animal; Encephal

2014
Influence of LPS-induced neuroinflammation on acetylcholinesterase activity in rat brain.
    Journal of neuroimmunology, 2008, Dec-15, Volume: 205, Issue:1-2

    Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cytokines; Disease Mo

2008
Protective effects of icariin on brain dysfunction induced by lipopolysaccharide in rats.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2010, Volume: 17, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Encephalitis; Epimedium; Flavonoids; Hippocampu

2010
Ibuprofen inhibits neuroinflammation and attenuates white matter damage following hypoxia-ischemia in the immature rodent brain.
    Brain research, 2011, Jul-21, Volume: 1402

    Topics: Animals; Animals, Newborn; Disease Models, Animal; Encephalitis; Humans; Hypoxia-Ischemia, Brain; Ib

2011
No improvement after chronic ibuprofen treatment in the 5XFAD mouse model of Alzheimer's disease.
    Neurobiology of aging, 2012, Volume: 33, Issue:4

    Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti

2012
Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury.
    Restorative neurology and neuroscience, 2012, Volume: 30, Issue:1

    Topics: Actins; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Cell

2012
Concurrent blockade of free radical and microsomal prostaglandin E synthase-1-mediated PGE2 production improves safety and efficacy in a mouse model of amyotrophic lateral sclerosis.
    Journal of neurochemistry, 2012, Volume: 122, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Amyotrophic Lateral Sclerosis; Analysis of Variance; Animals; Anti-Infl

2012
Contribution of brain inflammation to neuronal cell death in neuronopathic forms of Gaucher's disease.
    Brain : a journal of neurology, 2012, Volume: 135, Issue:Pt 6

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antigens, Differen

2012
Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat.
    Neuroscience, 2012, Dec-06, Volume: 225

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Injuries; Calcium-Bind

2012
A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats.
    Journal of neuroimmunology, 2013, Jan-15, Volume: 254, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cytokines; Disease Models, Animal; Dose-Res

2013
Protective effects of NSAIDs on the development of Alzheimer disease.
    Neurology, 2008, May-06, Volume: 70, Issue:19

    Topics: Age Factors; Aged; Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal

2008
Effect of dexamethasone, indomethacin, ibuprofen, and probenecid on carrageenan-induced brain inflammation.
    Journal of neurosurgery, 1986, Volume: 65, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Brain Edema; Capillary Permeability; Carrageenan; Cerebrovascular

1986