ibuprofen has been researched along with Blood Pressure, High in 59 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "We assessed 154 women for eligibility, of whom 100 met entry criteria, agreed to participate, and were randomized to receive postpartum ibuprofen or acetaminophen for first-line pain control." | 9.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "To investigate short-term efficacy and safety of a novel lipid ibuprofen formulation 1200 mg/day compared with standard ibuprofen 1200 mg/day and 2400 mg/day in episodic knee arthralgia/flaring pain." | 9.24 | A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study. ( Bierma-Zeinstra, SMA; Brew, J; Conaghan, PG; Kilbourn, A; Stoner, K; Wilson, R, 2017) |
| "A 4-week, multicentre, randomised, double-blind study has compared the effects of lumiracoxib 100 mg once daily (od) (n = 394) and ibuprofen 600 mg three times daily (tid) (n = 393) on ambulatory BP in osteoarthritis (OA) patients with controlled hypertension." | 9.14 | The effects of lumiracoxib 100 mg once daily vs. ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agents. ( Krammer, G; Lheritier, K; MacDonald, TM; Richard, D, 2010) |
| "Hypertensive osteoarthritis patients of 50 years at least whose office blood pressure was less than 140/90 mmHg on stable antihypertensive treatment were randomized to lumiracoxib (n = 394) 100 mg once daily or ibuprofen 600 mg three times daily (n = 393) and 24-h ambulatory blood pressure monitoring was performed at baseline and end of study." | 9.13 | Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial. ( Krammer, G; Lheritier, K; Littlejohn, TW; MacDonald, TM; Rebuli, R; Reginster, JY; Richard, D, 2008) |
| " Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability." | 7.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen." | 7.69 | Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. ( Horn, AC; Jarrett, SW, 1997) |
| "We assessed 154 women for eligibility, of whom 100 met entry criteria, agreed to participate, and were randomized to receive postpartum ibuprofen or acetaminophen for first-line pain control." | 5.27 | Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial. ( Blue, NR; Drake-Lavelle, S; Holbrook, BD; Katukuri, VR; Leeman, L; Mozurkewich, EL; Murray-Krezan, C; Weinberg, D, 2018) |
| "To investigate short-term efficacy and safety of a novel lipid ibuprofen formulation 1200 mg/day compared with standard ibuprofen 1200 mg/day and 2400 mg/day in episodic knee arthralgia/flaring pain." | 5.24 | A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study. ( Bierma-Zeinstra, SMA; Brew, J; Conaghan, PG; Kilbourn, A; Stoner, K; Wilson, R, 2017) |
| "In this double-blind, randomized, multicentre non-inferiority CV-safety trial, 444 patients (mean age 62 ± 10 years, 54% female) with osteoarthritis (92%) or rheumatoid arthritis (8%) and evidence of or at increased risk for coronary artery disease received celecoxib (100-200 mg bid), ibuprofen (600-800 mg tid), or naproxen (375-500 mg bid) with matching placebos in a 1: 1: 1 allocation, to assess the effect on 24-h ambulatory BP after 4 months." | 5.24 | Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) ( Beckerman, B; Borer, JS; Davey, DA; Fayyad, R; Flammer, AJ; Graham, DY; Husni, ME; Iorga, D; Krum, H; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wisniewski, LM; Yeomans, ND, 2017) |
| "In the pivotal efficacy and safety trials, discontinuation rates due to any cause and dyspepsia were significantly lower for the ibuprofen/famotidine combination versus ibuprofen alone." | 5.20 | One-year safety of ibuprofen/famotidine fixed combination versus ibuprofen alone: pooled analyses of two 24-week randomized, double-blind trials and a follow-on extension. ( Ball, J; Bello, AE; Grahn, AY; Holt, RJ; Kent, JD, 2015) |
| "A 4-week, multicentre, randomised, double-blind study has compared the effects of lumiracoxib 100 mg once daily (od) (n = 394) and ibuprofen 600 mg three times daily (tid) (n = 393) on ambulatory BP in osteoarthritis (OA) patients with controlled hypertension." | 5.14 | The effects of lumiracoxib 100 mg once daily vs. ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agents. ( Krammer, G; Lheritier, K; MacDonald, TM; Richard, D, 2010) |
| "Hypertensive osteoarthritis patients of 50 years at least whose office blood pressure was less than 140/90 mmHg on stable antihypertensive treatment were randomized to lumiracoxib (n = 394) 100 mg once daily or ibuprofen 600 mg three times daily (n = 393) and 24-h ambulatory blood pressure monitoring was performed at baseline and end of study." | 5.13 | Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial. ( Krammer, G; Lheritier, K; Littlejohn, TW; MacDonald, TM; Rebuli, R; Reginster, JY; Richard, D, 2008) |
| " We studied 17 women with arthritis and hypertension who were receiving fosinopril and HCTZ, and administered sequentially in random order ibuprofen, sulindac, and nabumetone for 1 month each, with an intervening 2-week washout period between each treatment period." | 5.09 | Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs. ( Cook, ME; Thakur, V; Wallin, JD, 1999) |
| "Fifteen women with arthritis and hypertension who were receiving lisinopril and HCT, and administered sequentially in random order ibuprofen, sulindac, and diclofenac for one month each, with an intervening two-week washout period between each treatment period." | 5.09 | Effects of non-steroidal anti-inflammatory drugs on hypertension control using angiotensin converting enzyme inhibitors and thiazide diuretics. ( Bhagat, K, 2001) |
| "We performed a randomized, double-blind, two-period crossover trial of ibuprofen (1800 mg per day) vs placebo treatment in patients older than 60 years of age with hypertension controlled with hydrochlorothiazide." | 5.08 | The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons. ( Avorn, J; Beaudet, MP; Choodnovskiy, I; Everitt, DE; Glynn, RJ; Gurwitz, JH; Monane, M, 1996) |
| " Twelve middle-aged black women with essential hypertension, controlled with 50 mg hydrochlorothiazide per day, randomly received 3200 mg ibuprofen and a placebo for 8 days." | 5.06 | The effect of high-dose short-term ibuprofen on antihypertensive control with hydrochlorothiazide. ( Bryan, DL; Cooper, LW; Lambert, CM; Lehany, AM; McKenney, JM; Wright, JT, 1989) |
| "In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t." | 5.06 | The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazide. ( Gribnau, FW; Koopmans, PP; Thien, T, 1987) |
| " As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA." | 3.78 | Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. ( Del Rio, R; Iturriaga, R; Madrid, C; Moya, EA; Parga, MJ, 2012) |
| "This was a post hoc analysis from the INternational VErapamil Trandolapril STudy (INVEST), which enrolled patients with hypertension and coronary artery disease." | 3.77 | Harmful effects of NSAIDs among patients with hypertension and coronary artery disease. ( Bavry, AA; Cooper-Dehoff, RM; Gong, Y; Handberg, EM; Khaliq, A; Pepine, CJ, 2011) |
| " Rofecoxib, an agent that selectively inhibits COX-2, has been shown to provide equivalent anti-inflammatory and analgesic efficacy to comparator non-selective NSAIDs in osteoarthritis (OA) and other pain models with a significant improvement in gastrointestinal (GI) safety and tolerability." | 3.71 | A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents. ( Bolognese, JA; Gertz, BJ; Krupa, D; Reicin, A; Sperling, RS, 2002) |
| "The current study was conducted to determine the potential influence of ibuprofen on the renal and systemic response to AT1 receptor blockade in conscious rats developing spontaneous hypertension." | 3.70 | Combined treatment with ibuprofen and the AT1 receptor antagonist candesartan in young spontaneously hypertensive rats. ( Morsing, P; Pollock, DM, 1999) |
| "We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen." | 3.69 | Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. ( Horn, AC; Jarrett, SW, 1997) |
| " Four variants of the course treatment were used: 1) monotherapy with enalapril maleate (2 mg twice a day); 2) enalapril maleate (5 mg twice a day) in combination with NSAID; 3) monotherapy with lisinopril (10 mg once a day); 4) lisinopril (10 mg once a day in combination with NSAID." | 2.70 | [Antihypertensive effect of enalapril and lisinopril administered in combination with nonsteroid anti-inflammatory agents]. ( Brodskaia, SA; Ivanov, SN; Savenkov, MP, 2001) |
| "Hydrochlorothiazide treatment decreased diastolic blood pressure to 83." | 2.67 | Assessment of blood pressure during treatment with naproxen or ibuprofen in hypertensive patients treated with hydrochlorothiazide. ( Goodfriend, TL; Klassen, D; Peterson, CA; Schuna, AA; Young, DY, 1993) |
| "Hypertension and sporadic Alzheimer's disease (AD) have been associated but clear pathophysiological links have not yet been demonstrated." | 1.38 | Role of neuroinflammation in hypertension-induced brain amyloid pathology. ( Ajmone-Cat, MA; Alleva, E; Branchi, I; Carnevale, D; Carnevale, L; Carullo, P; Cifelli, G; Cocozza, G; D'Andrea, I; Frati, A; Lembo, G; Madonna, M; Mascio, G; Minghetti, L, 2012) |
| "Ibuprofen was associated with a 3 mmHg increase in systolic blood pressure compared to naproxen (95% CI, 0." | 1.38 | Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension. ( Aljadhey, H; Blalock, SJ; Brater, DC; Hansen, RA; Murray, MD; Tu, W, 2012) |
| "Hypertension was induced by DOCA-salt." | 1.35 | Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates. ( Bhole, RP; Bhusari, KP; Chikhale, RV; Khedekar, PB, 2009) |
| " We explore the toxicities of OTC cough and cold medications, discuss mechanisms of dosing errors, and suggest why physicians should be more vigilant in specifically inquiring about OTCs when evaluating an ill child." | 1.31 | Toxicity of over-the-counter cough and cold medications. ( Gunn, VL; Liebelt, EL; Serwint, JR; Taha, SH, 2001) |
| " The chronic administration of hPTH reversed these effects." | 1.29 | Implication of parathyroid hormone for the development of hypertension in young spontaneously hypertensive rats. ( Kishimoto, H; Morii, H; Tsumura, K; Uchimoto, S; Yamashita, N, 1995) |
| "The patient discussed developed severe acute renal failure after strenuous exercise and therapeutic doses of ibuprofen and hydrochlorothiazide-triamterene." | 1.29 | Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, and triamterene. ( Sanders, LR, 1995) |
| "Ibuprofen treatment reduced the basal concentrations of all prostanoids to nearly undetectable levels and prevented their changes during hypotension and hypertension." | 1.28 | Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets. ( Aranda, JV; Beharry, K; Chatterjee, T; Chemtob, S; Rex, J; Varma, DR, 1991) |
| "Indomethacin was used to induce ubiquitous inhibition of prostaglandin synthesis and sulindac to inhibit prostaglandin synthesis in all tissues except the kidney." | 1.27 | Role of prostaglandins in the renal handling of a salt load in essential hypertension. ( Condorelli, M; Cuocolo, A; De Simone, A; Patrignani, P; Ricciardelli, B; Saccà, L; Trimarco, B; Volpe, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (13.56) | 18.7374 |
| 1990's | 18 (30.51) | 18.2507 |
| 2000's | 15 (25.42) | 29.6817 |
| 2010's | 17 (28.81) | 24.3611 |
| 2020's | 1 (1.69) | 2.80 |
| Authors | Studies |
|---|---|
| Chikhale, RV | 1 |
| Bhole, RP | 1 |
| Khedekar, PB | 1 |
| Bhusari, KP | 1 |
| Martins-Filho, PR | 1 |
| do Nascimento-Júnior, EM | 1 |
| Santos, VS | 1 |
| Bierma-Zeinstra, SMA | 1 |
| Brew, J | 1 |
| Stoner, K | 1 |
| Wilson, R | 1 |
| Kilbourn, A | 1 |
| Conaghan, PG | 1 |
| Fernández-Ruiz, I | 1 |
| Ruschitzka, F | 1 |
| Borer, JS | 1 |
| Krum, H | 1 |
| Flammer, AJ | 1 |
| Yeomans, ND | 1 |
| Libby, P | 1 |
| Lüscher, TF | 1 |
| Solomon, DH | 1 |
| Husni, ME | 1 |
| Graham, DY | 1 |
| Davey, DA | 1 |
| Wisniewski, LM | 1 |
| Menon, V | 1 |
| Fayyad, R | 1 |
| Beckerman, B | 1 |
| Iorga, D | 1 |
| Lincoff, AM | 1 |
| Nissen, SE | 1 |
| Dong, YH | 1 |
| Chang, CH | 1 |
| Wu, LC | 1 |
| Hwang, JS | 1 |
| Toh, S | 1 |
| Blue, NR | 1 |
| Murray-Krezan, C | 1 |
| Drake-Lavelle, S | 1 |
| Weinberg, D | 1 |
| Holbrook, BD | 1 |
| Katukuri, VR | 1 |
| Leeman, L | 1 |
| Mozurkewich, EL | 1 |
| Hirshberg, JS | 1 |
| Cahill, AG | 1 |
| Lohiya, GS | 1 |
| Lohiya, P | 1 |
| Krishna, V | 1 |
| Lohiya, S | 1 |
| Bello, AE | 1 |
| Grahn, AY | 1 |
| Ball, J | 1 |
| Kent, JD | 1 |
| Holt, RJ | 1 |
| Taha, AS | 1 |
| Olivon, VC | 1 |
| Aires, RD | 1 |
| Santiago, LB | 1 |
| Ramalho, LZ | 1 |
| Cortes, SF | 1 |
| Lemos, VS | 1 |
| MacDonald, TM | 2 |
| Reginster, JY | 1 |
| Littlejohn, TW | 1 |
| Richard, D | 2 |
| Lheritier, K | 2 |
| Krammer, G | 2 |
| Rebuli, R | 1 |
| Pavlicević, I | 1 |
| Kuzmanić, M | 1 |
| Rumboldt, M | 1 |
| Rumboldt, Z | 1 |
| Carnevale, D | 1 |
| Mascio, G | 1 |
| Ajmone-Cat, MA | 1 |
| D'Andrea, I | 1 |
| Cifelli, G | 1 |
| Madonna, M | 1 |
| Cocozza, G | 1 |
| Frati, A | 1 |
| Carullo, P | 1 |
| Carnevale, L | 1 |
| Alleva, E | 1 |
| Branchi, I | 1 |
| Lembo, G | 1 |
| Minghetti, L | 1 |
| Bavry, AA | 1 |
| Khaliq, A | 1 |
| Gong, Y | 1 |
| Handberg, EM | 1 |
| Cooper-Dehoff, RM | 1 |
| Pepine, CJ | 1 |
| Del Rio, R | 1 |
| Moya, EA | 1 |
| Parga, MJ | 1 |
| Madrid, C | 1 |
| Iturriaga, R | 1 |
| Herdeg, C | 1 |
| Geoghegan, P | 1 |
| Sexton, DJ | 1 |
| Giblin, L | 1 |
| O'Regan, A | 1 |
| Aljadhey, H | 1 |
| Tu, W | 1 |
| Hansen, RA | 1 |
| Blalock, SJ | 1 |
| Brater, DC | 1 |
| Murray, MD | 1 |
| Palmer, R | 1 |
| Weiss, R | 1 |
| Zusman, RM | 1 |
| Haig, A | 1 |
| Flavin, S | 1 |
| MacDonald, B | 1 |
| Singh, AK | 1 |
| Colvin, RB | 1 |
| Makris, A | 1 |
| Thornton, C | 1 |
| Hennessy, A | 1 |
| Hervás Angulo, A | 1 |
| Levy, JV | 1 |
| Reid, AL | 1 |
| Uchimoto, S | 1 |
| Tsumura, K | 1 |
| Kishimoto, H | 1 |
| Yamashita, N | 1 |
| Morii, H | 1 |
| Sanders, LR | 1 |
| Houston, MC | 1 |
| Weir, M | 1 |
| Gray, J | 1 |
| Ginsberg, D | 1 |
| Szeto, C | 1 |
| Kaihlenen, PM | 1 |
| Sugimoto, D | 1 |
| Runde, M | 1 |
| Lefkowitz, M | 1 |
| Minuz, P | 5 |
| Pancera, P | 3 |
| Ribul, M | 3 |
| Priante, F | 2 |
| Degan, M | 3 |
| Campedelli, A | 1 |
| Arosio, E | 4 |
| Lechi, A | 4 |
| Kailasam, MT | 1 |
| Lin, MC | 1 |
| Cervenka, JH | 1 |
| Parmer, RJ | 1 |
| Kennedy, BP | 1 |
| Ziegler, MG | 1 |
| O'Connor, DT | 1 |
| Klassen, D | 1 |
| Goodfriend, TL | 1 |
| Schuna, AA | 1 |
| Young, DY | 1 |
| Peterson, CA | 1 |
| Cole, DJ | 1 |
| Patel, PM | 1 |
| Reynolds, L | 1 |
| Drummond, JC | 1 |
| Marcantonio, S | 1 |
| Gurwitz, JH | 1 |
| Everitt, DE | 1 |
| Monane, M | 1 |
| Glynn, RJ | 1 |
| Choodnovskiy, I | 1 |
| Beaudet, MP | 1 |
| Avorn, J | 1 |
| Pirante, F | 1 |
| Mulkerrin, EC | 1 |
| Clark, BA | 1 |
| Epstein, FH | 1 |
| Horn, AC | 1 |
| Jarrett, SW | 1 |
| Pollock, DM | 1 |
| Morsing, P | 1 |
| Thakur, V | 1 |
| Cook, ME | 1 |
| Wallin, JD | 1 |
| Olivencia, G | 1 |
| Gunn, VL | 1 |
| Taha, SH | 1 |
| Liebelt, EL | 1 |
| Serwint, JR | 1 |
| Savenkov, MP | 1 |
| Ivanov, SN | 1 |
| Brodskaia, SA | 1 |
| Aizawa, T | 1 |
| Ishizaka, N | 1 |
| Usui, S | 1 |
| Ohashi, N | 1 |
| Ohno, M | 1 |
| Nagai, R | 1 |
| Bhagat, K | 1 |
| Gertz, BJ | 1 |
| Krupa, D | 1 |
| Bolognese, JA | 1 |
| Sperling, RS | 1 |
| Reicin, A | 1 |
| Kuhn, DC | 1 |
| Walenga, RW | 1 |
| Stuart, MJ | 1 |
| Chemtob, S | 1 |
| Beharry, K | 1 |
| Rex, J | 1 |
| Chatterjee, T | 1 |
| Varma, DR | 1 |
| Aranda, JV | 1 |
| Barrow, SE | 1 |
| Cockcroft, JR | 1 |
| Ritter, JM | 1 |
| Wright, JT | 1 |
| McKenney, JM | 1 |
| Lehany, AM | 1 |
| Bryan, DL | 1 |
| Cooper, LW | 1 |
| Lambert, CM | 1 |
| Capuzzo, MG | 1 |
| Lechi, C | 1 |
| Corsato, M | 1 |
| Dalla Riva, A | 1 |
| Velo, GP | 1 |
| Radack, KL | 1 |
| Deck, CC | 1 |
| Bloomfield, SS | 1 |
| Koopmans, PP | 1 |
| Thien, T | 1 |
| Gribnau, FW | 1 |
| O'Brien, WF | 1 |
| Golden, SM | 1 |
| Bibro, MC | 1 |
| Charkobardi, PK | 1 |
| Davis, SE | 1 |
| Hemming, VG | 1 |
| Trimarco, B | 1 |
| De Simone, A | 1 |
| Cuocolo, A | 1 |
| Ricciardelli, B | 1 |
| Volpe, M | 1 |
| Patrignani, P | 1 |
| Saccà, L | 1 |
| Condorelli, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen[NCT00346216] | Phase 4 | 24,081 participants (Actual) | Interventional | 2006-10-04 | Completed | ||
| A 4-week, Multicentre, Randomized, Double-blind, Double-dummy, Parallel Group Ambulatory Blood Pressure Monitoring Study to Investigate Whether Treatment With Lumiracoxib 100 mg Once Daily Results in an Improved 24-hour Blood Pressure Profile Compared to [NCT00267176] | Phase 4 | 1,020 participants | Interventional | 2005-11-30 | Completed | ||
| Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice[NCT00631514] | Phase 4 | 88 participants (Actual) | Interventional | 2005-01-31 | Completed | ||
| Effect of Non-steroidal Anti-inflammatory Use on Blood Pressure in Women With Hypertensive Disorders of Pregnancy: A Randomized Open Label Trial[NCT03824119] | Phase 4 | 200 participants (Anticipated) | Interventional | 2018-12-11 | Recruiting | ||
| Comparison of Supportive Therapies for Symptom Relief From Pediatric Upper Respiratory Infections (URIs)[NCT01814293] | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to loss of funding. No data was collected.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"VAS question How much pain do you have was graded on a scale from 0 to 100 with 0 indicating No pain and 100 indicating Worst possible pain." (NCT00346216)
Timeframe: ITT and MITT Population - Baseline to 42 months
| Intervention | Number of participants (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (ITT) N= 8014, 8001, 7928 | Change-Baseline to Mon1 (ITT) N=7382, 7379, 7325 | Change-Baseline to Mon2 (ITT) N=7180, 7090, 7149 | Change-Baseline to Mon4 (ITT) N=6777, 6696, 6740 | Change-Baseline to Mon8 (ITT) N=6230, 6137, 6159 | Change-Baseline to Mon12 (ITT) N=5792, 5696, 5846 | Change-Baseline to Mon18 (ITT) N=5310, 5181. 5246 | Change-Baseline to Mon24 (ITT) N=4818, 4776, 4785 | Change-Baseline to Mon30 (ITT) N=4140, 4069, 4086 | Change-Baseline to Mon36 (ITT) N=3692, 3627, 3635 | Change-Baseline to Mon42 (ITT) N=3469, 3406, 3439 | Baseline (MITT) N=7974, 7954, 7894 | Change-Baseline to Mon1 MITT N=7372, 7367, 7321 | Change-Baseline to Mon2 MITT N=7170, 7078, 7142 | Change-Baseline to Mon4 MITT N=6772, 6686, 6732 | Change-Baseline to Mon8 MITT N=6224, 6128, 6155 | Change-Baseline to Mon12 MITT N=5787, 5689, 5844 | Change-Baseline to Mon18 MITT N=5305, 5175, 5242 | Change-Baseline to Mon24 MITT N=4815, 4769, 4782 | Change-Baseline to Mon30 MITT N=4139, 4067, 4085 | Change-Baseline to Mon36 MITT N=3691, 3623, 3635 | Change-Baseline to Mon42 MITT N=3468, 3404, 3438 | |
| Celecoxib | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.3 | -10.5 | -10.1 | -11.4 | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.4 | -10.5 | -10.2 | -11.4 |
| Ibuprofen | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 |
| Naproxen | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.4 | -11.3 | -11.6 | -12.1 | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.3 | -11.3 | -11.6 | -12.1 |
MACE defined as the composite of CV death (including hemorrhagic death), non-fatal MI, non-fatal stroke, hospitalization for UA, revascularization or hospitalization for TIA (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 4.2 | 3.1 |
| Ibuprofen | 4.8 | 3.6 |
| Naproxen | 4.3 | 3.2 |
APTC events are defined as a composite of any of the following events: Death due to CV causes (including cardiac, cerebrovascular, venous thromboembolic, haemorrhagic, other vascular, or unknown cause); Non-fatal MI; Non-fatal stroke (including intracranial hemorrhages, stroke of ischemic or unknown etiology). (NCT00346216)
Timeframe: Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months
| Intervention | Percentage of Partcipants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 2.3 | 1.7 |
| Ibuprofen | 2.7 | 1.9 |
| Naproxen | 2.5 | 1.8 |
CSGIE include: Gastroduodenal (GD) hemorrhage, Gastric outlet obstruction, Gastroduodenal, small bowel or large bowel perforation, Large bowel hemorrhage, Small bowel hemorrhage, Acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage, Symptomatic gastric or duodenal ulcer (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 0.7 | 0.3 |
| Ibuprofen | 0.9 | 0.7 |
| Naproxen | 0.7 | 0.7 |
1 review available for ibuprofen and Blood Pressure, High
| Article | Year |
|---|---|
Hypertension: Ibuprofen increases blood pressure in patients with arthritis.
Topics: Arthritis; Blood Pressure; Global Health; Humans; Hypertension; Ibuprofen; Incidence | 2017 |
23 trials available for ibuprofen and Blood Pressure, High
| Article | Year |
|---|---|
A new lipid formulation of low dose ibuprofen shows non-inferiority to high dose standard ibuprofen: the FLARE study (flaring arthralgia relief evaluation in episodic flaring knee pain) - a randomised double-blind study.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Capsules; Double-Blind | 2017 |
Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement)
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Pressure; Celecoxib; Coronary | 2017 |
Effect of ibuprofen vs acetaminophen on postpartum hypertension in preeclampsia with severe features: a double-masked, randomized controlled trial.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-St | 2018 |
One-year safety of ibuprofen/famotidine fixed combination versus ibuprofen alone: pooled analyses of two 24-week randomized, double-blind trials and a follow-on extension.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Combinations; Drug | 2015 |
Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Blood Pressure Monitoring, Ambulatory | 2008 |
Interaction between antihypertensives and NSAIDs in primary care: a controlled trial.
Topics: Acetaminophen; Aged; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; B | 2008 |
The effects of lumiracoxib 100 mg once daily vs. ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agents.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Cyclooxygen | 2010 |
Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors.
Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Bloo | 2003 |
The effects of nonsteroidal anti-inflammatory drugs on blood pressures of patients with hypertension controlled by verapamil.
Topics: Adolescent; Adult; Aged; Blood Pressure; Double-Blind Method; Drug Interactions; Female; Humans; Hyp | 1995 |
Amlodipine and haemodynamic effects of cyclo-oxygenase inhibition.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Amlodipine; Biomarkers; Blood Pressure; Creatinine | 1995 |
Effects of an oral prostaglandin E1 agonist on blood pressure and its determinants in essential hypertension.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Baroreflex; Blood Pressure; Drug Interactions; | 1994 |
Assessment of blood pressure during treatment with naproxen or ibuprofen in hypertensive patients treated with hydrochlorothiazide.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Diastole; Double-Blind Method; Female; Humans; Hydro | 1993 |
The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Antihyperten | 1996 |
Changes in peripheral hemodynamics and vasodilating prostaglandins after high-dose short-term ibuprofen in chronically treated hypertensive patients.
Topics: 6-Ketoprostaglandin F1 alpha; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; C | 1996 |
Increased salt retention and hypertension from non-steroidal agents in the elderly.
Topics: Adult; Aged; Aging; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Hypertension; Ibuprofen | 1997 |
Antihypertensive effect of the combination of fosinopril and HCTZ is resistant to interference by nonsteroidal antiinflammatory drugs.
Topics: Acetaminophen; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Ar | 1999 |
[Antihypertensive effect of enalapril and lisinopril administered in combination with nonsteroid anti-inflammatory agents].
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihyperte | 2001 |
Effects of non-steroidal anti-inflammatory drugs on hypertension control using angiotensin converting enzyme inhibitors and thiazide diuretics.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive | 2001 |
Prostaglandin I2 and thromboxane B2 biosynthesis and haemodynamic effects of lisinopril.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Pressure; Compliance; Double-Blind Method; En | 1991 |
Effects of non-steroidal anti-inflammatory drugs on prostacyclin and thromboxane biosynthesis in patients with mild essential hypertension.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Blood Pressure; Chromatography, Affin | 1990 |
The effect of high-dose short-term ibuprofen on antihypertensive control with hydrochlorothiazide.
Topics: Adult; Aged; Blood Pressure; Dinoprostone; Double-Blind Method; Drug Administration Schedule; Electr | 1989 |
Ibuprofen interferes with the efficacy of antihypertensive drugs. A randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Blood Pressure; Cl | 1987 |
The influence of ibuprofen, diclofenac and sulindac on the blood pressure lowering effect of hydrochlorothiazide.
Topics: Adult; Aged; Aldosterone; Blood Pressure; Clinical Trials as Topic; Creatinine; Diclofenac; Drug The | 1987 |
35 other studies available for ibuprofen and Blood Pressure, High
| Article | Year |
|---|---|
Synthesis and pharmacological investigation of 3-(substituted 1-phenylethanone)-4-(substituted phenyl)-1, 2, 3, 4-tetrahydropyrimidine-5-carboxylates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Blood Pressure; Edema; Hyper | 2009 |
No current evidence supporting risk of using Ibuprofen in patients with COVID-19.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Betacoronavirus; Coronavirus Infections; COVID-19; Diabetes | 2020 |
Comparative cardiovascular safety of nonsteroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Celecoxib; Cyclooxygenase 2 In | 2018 |
Pain relief: determining the safety of ibuprofen with postpartum preeclampsia.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Double-Blind Method; Female; Humans; Hypertension; Ibuprofe | 2018 |
Death related to Ibuprofen, valdecoxib, and medical errors: case report and medicolegal issues.
Topics: Acute Kidney Injury; Adult; Anti-Inflammatory Agents, Non-Steroidal; Contusions; Fatal Outcome; Fema | 2013 |
The ibuprofen-famotidine combined pill - a promise fulfilled.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Dyspepsia; Famotidine; Female; Histamine H2 Antagonists; Hu | 2015 |
Mas receptor overexpression increased Ang-(1-7) relaxation response in renovascular hypertensive rat carotid.
Topics: Angiotensin I; Animals; Carotid Arteries; Gene Expression Regulation; Hypertension; Ibuprofen; Male; | 2015 |
Role of neuroinflammation in hypertension-induced brain amyloid pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cerebrovascular Circulation; Disease Model | 2012 |
Harmful effects of NSAIDs among patients with hypertension and coronary artery disease.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Blood Pressure; Celec | 2011 |
Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular System; Carotid Bod | 2012 |
[Pericarditis in an athlete. How long must he abstain from sports?].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Colchicine; Drug Therapy, Combination; Exercise Test | 2011 |
Taught a lesson by taut skin.
Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroid | 2012 |
Comparative effects of non-steroidal anti-inflammatory drugs (NSAIDs) on blood pressure in patients with hypertension.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive A | 2012 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 36-2003. A 68-year-old woman with impaired renal function.
Topics: Acute Kidney Injury; Aged; Biopsy; Diagnosis, Differential; Female; Granuloma; Humans; Hypertension; | 2003 |
Postpartum hypertension and nonsteroidal analgesia.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Hypertension; Ibuprofen; Indomethaci | 2004 |
[Hypertension emergency as a side-effect of taking NSAIDs].
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Back Pain; Emergencies; Humans; Hyperten | 2004 |
To keep blood pressure down, go easy on painkillers.
Topics: Analgesics; Female; Humans; Hypertension; Ibuprofen | 2005 |
Link found between over-the-counter pain relievers and hypertension.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Humans; Hypertension; Ibuprofen; Nonprescription Drugs | 2005 |
Effect of ibuprofen on systolic blood pressure and aortic PGI2 production in spontaneously hypertensive rats (SHR).
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Epoprosten | 1982 |
Antihypertensive effect of thiazides.
Topics: Aged; Arthritis; Drug Interactions; Humans; Hypertension; Ibuprofen; Male; Pindolol | 1981 |
Implication of parathyroid hormone for the development of hypertension in young spontaneously hypertensive rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Arginine; Blood Pressure; Drug Synergism; Hypertension | 1995 |
Exercise-induced acute renal failure associated with ibuprofen, hydrochlorothiazide, and triamterene.
Topics: Acute Kidney Injury; Catecholamines; Cytokines; Eicosanoids; Hormones; Hydrochlorothiazide; Hyperten | 1995 |
Temporary focal cerebral ischemia in spontaneously hypertensive rats: the effect of ibuprofen on infarct volume.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Cerebral Infarction; Cyclooxygenase Inhibitors; Hyperten | 1993 |
Ibuprofen-induced aseptic meningitis in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Hypertension; Ibuprofen; Mal | 1997 |
Combined treatment with ibuprofen and the AT1 receptor antagonist candesartan in young spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzimidazoles; | 1999 |
Life-threatening illness in a nontransfusable patient: a health care challenge.
Topics: Abdominal Pain; Adult; Analgesics, Non-Narcotic; Anemia, Iron-Deficiency; Appendicitis; Epoetin Alfa | 2000 |
Toxicity of over-the-counter cough and cold medications.
Topics: Acetaminophen; Antitussive Agents; Bradycardia; Brompheniramine; Cardiovascular Diseases; Child, Pre | 2001 |
Angiotensin II and catecholamines increase plasma levels of 8-epi-prostaglandin F(2alpha) with different pressor dependencies in rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase Inhibitors; Dinopro | 2002 |
A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Clinical Trials, Phase II as Topic; Clinic | 2002 |
[Ibuprofen and antihypertensive drugs].
Topics: Antihypertensive Agents; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; | 1991 |
A prostacyclin analogue crosses the in vitro perfused human placenta and improves transfer in some pathologic states.
Topics: Antipyrine; Diabetes Mellitus, Type 1; Epoprostenol; Female; Humans; Hypertension; Ibuprofen; In Vit | 1991 |
Ibuprofen enhances retinal and choroidal blood flow autoregulation in newborn piglets.
Topics: Animals; Animals, Newborn; Blood Pressure; Choroid; Homeostasis; Hypertension; Hypotension; Ibuprofe | 1991 |
Antihypertensive activity of enalapril. Effect of ibuprofen and different salt intakes.
Topics: 6-Ketoprostaglandin F1 alpha; Adult; Aldosterone; Angiotensin-Converting Enzyme Inhibitors; Blood Pr | 1987 |
Short-term responses in neonatal lambs after infusion of group B streptococcal extract.
Topics: Animals; Animals, Newborn; Cell Extracts; Dinoprost; Female; Hypertension; Ibuprofen; Infusions, Par | 1985 |
Role of prostaglandins in the renal handling of a salt load in essential hypertension.
Topics: Adolescent; Adult; Blood Pressure; Cardiac Output; Diuresis; Female; Humans; Hypertension; Ibuprofen | 1985 |