Page last updated: 2024-10-28
ibuprofen and Asthma
ibuprofen has been researched along with Asthma in 52 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period." | 9.41 | Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 9.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 9.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined." | 9.22 | Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016) |
| "To determine the prevalence of ibuprofen-sensitive asthma in school-aged children with mild or moderate persistent asthma." | 9.11 | The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. ( Carter, ER; Debley, JS; Gibson, RL; Redding, GJ; Rosenfeld, M, 2005) |
| "Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks." | 9.10 | Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002) |
| "We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen." | 9.05 | Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020) |
| "Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations." | 8.84 | A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007) |
| "Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1." | 7.81 | Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015) |
| "To investigate the association between ibuprofen use and pulmonary function in children with Asthma." | 7.81 | Short-term ibuprofen treatment and pulmonary function in children with asthma. ( Huang, CS; Su, YM; Wan, KS, 2015) |
| "Aspirin-sensitive asthma, aspirin-intolerant asthma, aspirin- (or non-steroidal anti-inflammatory drug [NSAID]) exacerbated respiratory disease are terms for a disorder commonly described as affecting adults aged > 30y." | 7.73 | A teenager with severe asthma exacerbation following ibuprofen. ( Palmer, GM, 2005) |
| "We describe the case of a 40 year old woman, who had suffered from asthma since infancy, with a negative case history of asthma induced by aspirin or nonsteroidal anti-inflammatory (NSAID) agents, who died after ingesting 400 mg of ibuprofen." | 7.69 | Asthma death induced by ibuprofen. ( Antonicelli, L; Tagliabracci, A, 1995) |
| "A case of an adverse reaction occurring in a 53-year-old, aspirin-sensitive asthmatic male with nasal polyps following administration of a 400-mg ibuprofen tablet is reported." | 7.66 | Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report. ( Merritt, GJ; Selle, RI, 1978) |
| "Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene." | 7.65 | Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A; Zmuda, A, 1976) |
| " The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years." | 5.51 | Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial. ( Braithwaite, I; Dalziel, SR; Fernando, K; Haskell, L; Hoare, K; McKinlay, CJ; Riley, J; Tan, E, 2022) |
| "To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period." | 5.41 | Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021) |
| "The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial." | 5.34 | Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020) |
| "To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined." | 5.22 | Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016) |
| "Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking." | 5.22 | Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016) |
| "To determine the prevalence of ibuprofen-sensitive asthma in school-aged children with mild or moderate persistent asthma." | 5.11 | The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. ( Carter, ER; Debley, JS; Gibson, RL; Redding, GJ; Rosenfeld, M, 2005) |
| "Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks." | 5.10 | Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002) |
| "To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever." | 5.09 | The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999) |
| "We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen." | 5.05 | Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020) |
| "Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months." | 4.95 | Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. ( Boner, A; Chiarugi, A; de Martino, M; De' Angelis, GL; Montini, G, 2017) |
| "Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations." | 4.84 | A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007) |
| "This paper describes two studies in children with fever in which the safety of ibuprofen was compared with that of paracetamol." | 4.82 | The safety of ibuprofen suspension in children. ( Lesko, SM, 2003) |
| " For asthma, albuterol was reported most frequently (77." | 3.88 | Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. ( Ansari, S; Bandoli, G; Chambers, CD; Hulugalle, A; Kuo, GM; Palmsten, K; Xu, R, 2018) |
| "To investigate the association between ibuprofen use and pulmonary function in children with Asthma." | 3.81 | Short-term ibuprofen treatment and pulmonary function in children with asthma. ( Huang, CS; Su, YM; Wan, KS, 2015) |
| "Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1." | 3.81 | Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015) |
| "Aspirin-sensitive asthma, aspirin-intolerant asthma, aspirin- (or non-steroidal anti-inflammatory drug [NSAID]) exacerbated respiratory disease are terms for a disorder commonly described as affecting adults aged > 30y." | 3.73 | A teenager with severe asthma exacerbation following ibuprofen. ( Palmer, GM, 2005) |
| "We describe the case of a 40 year old woman, who had suffered from asthma since infancy, with a negative case history of asthma induced by aspirin or nonsteroidal anti-inflammatory (NSAID) agents, who died after ingesting 400 mg of ibuprofen." | 3.69 | Asthma death induced by ibuprofen. ( Antonicelli, L; Tagliabracci, A, 1995) |
| "A case of an adverse reaction occurring in a 53-year-old, aspirin-sensitive asthmatic male with nasal polyps following administration of a 400-mg ibuprofen tablet is reported." | 3.66 | Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report. ( Merritt, GJ; Selle, RI, 1978) |
| "Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene." | 3.65 | Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A; Zmuda, A, 1976) |
| " However, adverse effects should be taken into account in the choice between ibuprofen and acetaminophen." | 2.44 | [Ibuprofen in childhood: evidence-based review of efficacy and safety]. ( Cosson, MA; Landre-Peigne, C; Leroy, S; Mosca, A; Pons, G, 2007) |
| "Ibuprofen use was significantly lower in children diagnosed with wheezing (n = 22, 52." | 1.46 | Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. ( Elizur, A; Ganor, S; Kozer, E; Levine, H; Matok, I; Perlman, A, 2017) |
Research
Studies (52)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (17.31) | 18.7374 |
| 1990's | 3 (5.77) | 18.2507 |
| 2000's | 16 (30.77) | 29.6817 |
| 2010's | 20 (38.46) | 24.3611 |
| 2020's | 4 (7.69) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Tan, E | 2 |
| Hoare, K | 2 |
| Riley, J | 3 |
| Fernando, K | 1 |
| Haskell, L | 1 |
| McKinlay, CJ | 1 |
| Dalziel, SR | 3 |
| Braithwaite, I | 3 |
| Sherbash, M | 1 |
| Furuya-Kanamori, L | 1 |
| Nader, JD | 1 |
| Thalib, L | 1 |
| McKinlay, C | 1 |
| Okesene-Gafa, K | 1 |
| Semprini, A | 1 |
| Sheridan, N | 1 |
| Grant, C | 1 |
| Johnson, D | 1 |
| Weatherall, M | 2 |
| Asher, I | 1 |
| Beasley, R | 2 |
| Sheehan, WJ | 3 |
| Paul, IM | 2 |
| Mauger, DT | 2 |
| Moy, JN | 2 |
| Szefler, SJ | 2 |
| Jackson, DJ | 2 |
| Fitzpatrick, AM | 2 |
| Cabana, MD | 2 |
| Covar, R | 2 |
| Robison, RG | 2 |
| Phipatanakul, W | 3 |
| de Martino, M | 1 |
| Chiarugi, A | 1 |
| Boner, A | 1 |
| Montini, G | 1 |
| De' Angelis, GL | 1 |
| Palmsten, K | 1 |
| Hulugalle, A | 1 |
| Bandoli, G | 1 |
| Kuo, GM | 1 |
| Ansari, S | 1 |
| Xu, R | 1 |
| Chambers, CD | 1 |
| Wurth, M | 1 |
| Papantonakis, CM | 1 |
| Nevel, RJ | 1 |
| Thomas, CS | 1 |
| Sokolow, AG | 1 |
| Moore, PE | 1 |
| Rosas-Salazar, C | 1 |
| Heinzl, S | 1 |
| Thapa, SS | 1 |
| Scott, J | 1 |
| Sánchez-Borges, M | 1 |
| Park, HS | 1 |
| Sordillo, JE | 1 |
| Scirica, CV | 1 |
| Rifas-Shiman, SL | 1 |
| Gillman, MW | 1 |
| Bunyavanich, S | 1 |
| Camargo, CA | 1 |
| Weiss, ST | 1 |
| Gold, DR | 1 |
| Litonjua, AA | 1 |
| Shaheen, SO | 1 |
| Su, YM | 1 |
| Huang, CS | 1 |
| Wan, KS | 1 |
| King, G | 1 |
| Byrne, A | 1 |
| Fleming, P | 1 |
| Boehmer, SJ | 1 |
| Bacharier, LB | 1 |
| Holguin, F | 1 |
| Lemanske, RF | 1 |
| Martinez, FD | 1 |
| Pongracic, JA | 1 |
| Beigelman, A | 1 |
| Baxi, SN | 1 |
| Benson, M | 1 |
| Blake, K | 1 |
| Chmiel, JF | 1 |
| Daines, CL | 1 |
| Daines, MO | 1 |
| Gaffin, JM | 1 |
| Gentile, DA | 1 |
| Gower, WA | 1 |
| Israel, E | 1 |
| Kumar, HV | 1 |
| Lang, JE | 1 |
| Lazarus, SC | 1 |
| Lima, JJ | 1 |
| Ly, N | 1 |
| Marbin, J | 1 |
| Morgan, WJ | 1 |
| Myers, RE | 1 |
| Olin, JT | 1 |
| Peters, SP | 1 |
| Raissy, HH | 1 |
| Ross, K | 1 |
| Sorkness, CA | 1 |
| Thyne, SM | 1 |
| Wechsler, ME | 1 |
| Mayor, S | 1 |
| Venkatesan, P | 1 |
| Hunt, A | 1 |
| McDouall, A | 1 |
| Waqanivavalagi, S | 1 |
| Stanley, T | 1 |
| Mitchell, EA | 1 |
| Matok, I | 1 |
| Elizur, A | 1 |
| Perlman, A | 1 |
| Ganor, S | 1 |
| Levine, H | 1 |
| Kozer, E | 1 |
| Uzoigwe, CE | 1 |
| Ali, OH | 1 |
| Haines, DD | 1 |
| Varga, B | 1 |
| Bak, I | 1 |
| Juhasz, B | 1 |
| Mahmoud, FF | 1 |
| Kalantari, H | 1 |
| Gesztelyi, R | 1 |
| Lekli, I | 1 |
| Czompa, A | 1 |
| Tosaki, A | 1 |
| Olze, H | 1 |
| Lau, S | 1 |
| Förster, U | 1 |
| Selbst, SM | 1 |
| Osterhoudt, K | 1 |
| Lesko, SM | 3 |
| Rosado, A | 1 |
| Vives, R | 1 |
| González, R | 1 |
| Rodríguez, J | 1 |
| South, M | 1 |
| Kader, A | 1 |
| Hildebrandt, T | 1 |
| Powell, C | 1 |
| Kauffman, RE | 1 |
| Lieh-Lai, M | 1 |
| Body, R | 1 |
| Potier, K | 1 |
| Palmer, GM | 1 |
| Debley, JS | 1 |
| Carter, ER | 1 |
| Gibson, RL | 1 |
| Rosenfeld, M | 1 |
| Redding, GJ | 1 |
| Kidon, MI | 1 |
| Kang, LW | 1 |
| Chin, CW | 1 |
| Hoon, LS | 1 |
| See, Y | 1 |
| Goh, A | 1 |
| Lin, JT | 1 |
| Chay, OM | 1 |
| Dreyfus, DH | 1 |
| Randolph, CC | 1 |
| Leroy, S | 1 |
| Mosca, A | 1 |
| Landre-Peigne, C | 1 |
| Cosson, MA | 1 |
| Pons, G | 1 |
| Kanabar, D | 2 |
| Dale, S | 1 |
| Rawat, M | 1 |
| Sharma, SK | 1 |
| Antonicelli, L | 1 |
| Tagliabracci, A | 1 |
| Kroegel, C | 1 |
| Matthys, H | 1 |
| Mitchell, AA | 2 |
| Kawai, K | 1 |
| Shirai, T | 1 |
| Suzuki, K | 1 |
| Chida, K | 1 |
| Nakamura, H | 1 |
| Goraya, JS | 1 |
| Virdi, VS | 1 |
| Louik, C | 1 |
| Vezina, RM | 1 |
| Kordansky, D | 1 |
| Adkinson, NF | 1 |
| Norman, PS | 1 |
| Rosenthal, RR | 1 |
| Merritt, GJ | 1 |
| Selle, RI | 1 |
| Szczeklik, A | 1 |
| Gryglewski, RJ | 1 |
| Czerniawska-Mysik, G | 1 |
| Zmuda, A | 1 |
| Andersen, JS | 1 |
| Guldager, H | 1 |
| Ayres, JG | 1 |
| Fleming, DM | 1 |
| Whittington, RM | 1 |
| Mathur, SL | 1 |
| Watts, MJ | 1 |
Clinical Trials (2)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319] | Phase 3 | 300 participants (Actual) | Interventional | 2013-02-28 | Completed | ||
| Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators[NCT03664466] | 0 participants (Actual) | Interventional | 2021-04-29 | Withdrawn (stopped due to Inadequate funding) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Asthma Control Days
proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | proportion of days (Mean) |
|---|---|
| Acetaminophen | .86 |
| Ibuprofen | .87 |
Asthma Rescue Medication Use
average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | inhalations per week (Mean) |
|---|---|
| Acetaminophen | 2.8 |
| Ibuprofen | 3 |
Exacerbation Frequency
the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | asthma exacerbations per 46 weeks (Mean) |
|---|---|
| Acetaminophen | 0.81 |
| Ibuprofen | .87 |
Health Care Utilization
frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period
| Intervention | unscheduled health visits per 46 weeks (Mean) |
|---|---|
| Acetaminophen | .75 |
| Ibuprofen | .76 |
Reviews
9 reviews available for ibuprofen and Asthma
| Article | Year |
|---|---|
Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials.
Topics: Acetaminophen; Asthma; Child; Disease Progression; Humans; Ibuprofen; Randomized Controlled Trials a | 2020 |
Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal.
Topics: Abnormalities, Multiple; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cerebellar Di | 2017 |
The safety of ibuprofen suspension in children.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev | 2003 |
How safe is ibuprofen in febrile asthmatic children?
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child, Preschool; Contrai | 2004 |
Ibuprofen and increased morbidity in children with asthma: fact or fiction?
Topics: Asthma; Child; Humans; Ibuprofen; Morbidity | 2004 |
Best evidence topic report. Non-steroidal anti-inflammatory drugs and exacerbations of asthma in children.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Emergencies; Fever; Humans; Ibuprofen; Male | 2004 |
[Ibuprofen in childhood: evidence-based review of efficacy and safety].
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chickenpox; Child; Gastrointes | 2007 |
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms.
Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Asthma; Child; Fever; Hospitalization; Humans; | 2007 |
Ibuprofen and asthma in paediatric populations: clinical concern or clinical reality?
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Cyclooxygenase Inhibitors; Hu | 2007 |
Trials
10 trials available for ibuprofen and Asthma
| Article | Year |
|---|---|
Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial.
Topics: Acetaminophen; Asthma; Fever; Grounded Theory; Humans; Ibuprofen; Infant; Infant Welfare | 2022 |
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen | 2020 |
Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma.
Topics: Acetaminophen; Asthma; Child; Double-Blind Method; Humans; Ibuprofen | 2021 |
[In process].
Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe | 2016 |
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma.
Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci | 2016 |
Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Female; Humans; Ibuprofen; Infant; Infant, Newborn; | 2016 |
The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Provocation Tests; Child; Double-Blind Me | 2005 |
The safety of acetaminophen and ibuprofen among children younger than two years old.
Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method; | 1999 |
Asthma morbidity after the short-term use of ibuprofen in children.
Topics: Acetaminophen; Age Factors; Ambulatory Care; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non | 2002 |
Asthma improved by nonsteroidal anti-inflammatory drugs.
Topics: Airway Resistance; Anti-Inflammatory Agents; Aspirin; Asthma; Clinical Trials as Topic; Female; Forc | 1978 |
Other Studies
33 other studies available for ibuprofen and Asthma
| Article | Year |
|---|---|
Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma.
Topics: Adult; Albuterol; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; Et | 2018 |
Risk Factors Associated with Asthma Development and Control in Children. Mouse Infestation, Antipyretics, Respiratory Viruses, and Allergic Sensitization.
Topics: Acetaminophen; Allergens; Animals; Antipyretics; Asthma; Child; Humans; Hypersensitivity; Ibuprofen; | 2017 |
Double pylorus.
Topics: Aged; Analgesics, Non-Narcotic; Asthma; Back Pain; Duodenal Diseases; Endoscopy; Gastric Fistula; Ga | 2018 |
NSAID Hypersensitivity.
Topics: Allergens; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Disease Progression; Drug Hy | 2019 |
Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chi | 2015 |
Acetaminophen and childhood asthma: pill-popping at our peril?
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Hu | 2015 |
Short-term ibuprofen treatment and pulmonary function in children with asthma.
Topics: Asthma; Breath Tests; Case-Control Studies; Child; Female; Forced Expiratory Volume; Humans; Ibuprof | 2015 |
A case of severe NSAID exacerbated respiratory disease (NERD) following a dental procedure in a child.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclooxygenase 2 Inhibitors; Drug Hyper | 2016 |
Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev | 2016 |
Paracetamol no worse than ibuprofen in children with mild asthma.
Topics: Acetaminophen; Asthma; Child; Child, Preschool; Disease Progression; Female; Humans; Ibuprofen; Male | 2016 |
Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Cross-Sectio | 2017 |
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans; | 2016 |
Acetaminophen versus Ibuprofen in Mild Persistent Asthma.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans; | 2016 |
Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen.
Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Asthma; Drug Therapy, Combination; Ginkgo biloba; | 2011 |
Samter's triad and eicosanoid imbalance in children with recurrent nasal polyps.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Diclofenac; Drug Hypersensitivit | 2012 |
Pediatric emergency medicine: legal briefs.
Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis; | 2012 |
Can NSAIDs intolerance disappear? A study of three cases.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Drug Hypersensitivity; Forced Expir | 2003 |
Pain relievers and asthma.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Humans; Ibuprofen; Morbidity; Risk | 2003 |
A teenager with severe asthma exacerbation following ibuprofen.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Contraindications; Humans; Ibu | 2005 |
Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, Asian, atopic children.
Topics: Acetaminophen; Administration, Oral; Adolescent; Allergens; Angioedema; Anti-Inflammatory Agents, No | 2005 |
Characterization of an anaphylactoid reaction to omalizumab.
Topics: Adult; Anaphylaxis; Angioedema; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agent | 2006 |
Ibuprofen (Brufen) induced bronchial asthma.
Topics: Asthma; Drug Hypersensitivity; Headache; Humans; Ibuprofen | 1984 |
[Prevention of food hypersensitivities with aspirin].
Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Food Hypersensitivity; Ibuprofen; Indomethacin; Milk; P | 1980 |
Asthma death induced by ibuprofen.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Asthma; Fatal Outcome; Female; Humans; Ibupro | 1995 |
Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics.
Topics: Asthma; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Humans; Ibuprofen; Leukocyte | 1993 |
[Mild intermittent aspirin-induced asthma in a patient who became asymptomatic after removal of pet hamsters from home].
Topics: Adult; Allergens; Animals; Animals, Domestic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asth | 2000 |
To the editor: Exacerbation of asthma by ibuprofen in a very young child.
Topics: Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchodilator Agents; Child, Preschool; | 2001 |
Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report.
Topics: Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Humans; Ibuprofen; Male; Middle Aged | 1978 |
Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations.
Topics: Adolescent; Adult; Aspirin; Asthma; Constriction, Pathologic; Dextropropoxyphene; Drug Hypersensitiv | 1976 |
[Ibuprofen triggered asthma attack in a patient with known aspirin hypersensitivity].
Topics: Aged; Aspirin; Asthma; Drug Hypersensitivity; Humans; Ibuprofen; Male | 1989 |
Asthma death due to ibuprofen.
Topics: Acute Disease; Aged; Albuterol; Asthma; Beclomethasone; Drug Interactions; Female; Humans; Ibuprofen | 1987 |
Ibuprofen in bronchial asthma.
Topics: Adult; Asthma; Female; Humans; Ibuprofen; Male; Status Asthmaticus | 1988 |
Ibuprofen and asthma.
Topics: Aged; Asthma; Female; Humans; Ibuprofen; Status Asthmaticus | 1987 |