ibuprofen and Asthma studies

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

Excerpt	Relevance	Reference
"To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period."	9.41	Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."	9.34	Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."	9.22	Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined."	9.22	Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016)
"To determine the prevalence of ibuprofen-sensitive asthma in school-aged children with mild or moderate persistent asthma."	9.11	The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. ( Carter, ER; Debley, JS; Gibson, RL; Redding, GJ; Rosenfeld, M, 2005)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."	9.10	Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."	9.05	Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."	8.84	A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."	7.81	Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
"To investigate the association between ibuprofen use and pulmonary function in children with Asthma."	7.81	Short-term ibuprofen treatment and pulmonary function in children with asthma. ( Huang, CS; Su, YM; Wan, KS, 2015)
"Aspirin-sensitive asthma, aspirin-intolerant asthma, aspirin- (or non-steroidal anti-inflammatory drug [NSAID]) exacerbated respiratory disease are terms for a disorder commonly described as affecting adults aged > 30y."	7.73	A teenager with severe asthma exacerbation following ibuprofen. ( Palmer, GM, 2005)
"We describe the case of a 40 year old woman, who had suffered from asthma since infancy, with a negative case history of asthma induced by aspirin or nonsteroidal anti-inflammatory (NSAID) agents, who died after ingesting 400 mg of ibuprofen."	7.69	Asthma death induced by ibuprofen. ( Antonicelli, L; Tagliabracci, A, 1995)
"A case of an adverse reaction occurring in a 53-year-old, aspirin-sensitive asthmatic male with nasal polyps following administration of a 400-mg ibuprofen tablet is reported."	7.66	Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report. ( Merritt, GJ; Selle, RI, 1978)
"Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene."	7.65	Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A; Zmuda, A, 1976)
" The Paracetamol and Ibuprofen in the Primary Prevention of Asthma in Tamariki (PIPPA Tamariki) trial is an open-label, randomised controlled trial aiming to determine whether paracetamol treatment, compared with ibuprofen treatment, as required for fever and pain in the first year of life, increases the risk of asthma at age six years."	5.51	Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial. ( Braithwaite, I; Dalziel, SR; Fernando, K; Haskell, L; Hoare, K; McKinlay, CJ; Riley, J; Tan, E, 2022)
"To prospectively evaluate associations between acetaminophen use and asthma in 300 children aged 1-5 years, we conducted a double blind, randomized, controlled trial where parents administered blinded forms of either acetaminophen or ibuprofen as needed to their children over a 48 week period."	5.41	Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. ( Cabana, MD; Covar, R; Fitzpatrick, AM; Jackson, DJ; Mauger, DT; Moy, JN; Paul, IM; Phipatanakul, W; Robison, RG; Sheehan, WJ; Szefler, SJ, 2021)
"The Paracetamol and Ibuprofen in Primary Prevention of Asthma in Tamariki trial is a multicentre, open-label, two-arm parallel randomised controlled trial."	5.34	Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. ( Asher, I; Beasley, R; Braithwaite, I; Dalziel, SR; Grant, C; Hoare, K; Johnson, D; McKinlay, C; Okesene-Gafa, K; Riley, J; Semprini, A; Sheridan, N; Tan, E; Weatherall, M, 2020)
"To undertake a randomised controlled trial (RCT) of paracetamol versus ibuprofen use during infancy to determine if paracetamol is associated with an increased risk of developing asthma, the preferred method of recruitment needs to be determined."	5.22	Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. ( Beasley, R; Braithwaite, I; Dalziel, SR; Hunt, A; McDouall, A; Mitchell, EA; Riley, J; Stanley, T; Waqanivavalagi, S; Weatherall, M, 2016)
"Studies have suggested an association between frequent acetaminophen use and asthma-related complications among children, leading some physicians to recommend that acetaminophen be avoided in children with asthma; however, appropriately designed trials evaluating this association in children are lacking."	5.22	Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. ( Bacharier, LB; Baxi, SN; Beigelman, A; Benson, M; Blake, K; Boehmer, SJ; Cabana, MD; Chmiel, JF; Covar, R; Daines, CL; Daines, MO; Fitzpatrick, AM; Gaffin, JM; Gentile, DA; Gower, WA; Holguin, F; Israel, E; Jackson, DJ; Kumar, HV; Lang, JE; Lazarus, SC; Lemanske, RF; Lima, JJ; Ly, N; Marbin, J; Martinez, FD; Mauger, DT; Morgan, WJ; Moy, JN; Myers, RE; Olin, JT; Paul, IM; Peters, SP; Phipatanakul, W; Pongracic, JA; Raissy, HH; Robison, RG; Ross, K; Sheehan, WJ; Sorkness, CA; Szefler, SJ; Thyne, SM; Wechsler, ME, 2016)
"To determine the prevalence of ibuprofen-sensitive asthma in school-aged children with mild or moderate persistent asthma."	5.11	The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. ( Carter, ER; Debley, JS; Gibson, RL; Redding, GJ; Rosenfeld, M, 2005)
"Rather than supporting the hypothesis that ibuprofen increases asthma morbidity among children who are not known to be sensitive to aspirin or other nonsteroidal antiinflammatory drugs, these data suggest that compared with acetaminophen, ibuprofen may reduce such risks."	5.10	Asthma morbidity after the short-term use of ibuprofen in children. ( Lesko, SM; Louik, C; Mitchell, AA; Vezina, RM, 2002)
"To compare the incidence of serious adverse clinical events among children <2 years old given ibuprofen and acetaminophen to control fever."	5.09	The safety of acetaminophen and ibuprofen among children younger than two years old. ( Lesko, SM; Mitchell, AA, 1999)
"We conducted a meta-analysis of randomized controlled trials (RCTs) that compared wheezing and asthma exacerbations in children taking paracetamol versus ibuprofen."	5.05	Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. ( Furuya-Kanamori, L; Nader, JD; Sherbash, M; Thalib, L, 2020)
"Ibuprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) for the treatment of inflammation, mild-to-moderate pain and fever in children, and is the only NSAID approved for use in children aged ≥3 months."	4.95	Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. ( Boner, A; Chiarugi, A; de Martino, M; De' Angelis, GL; Montini, G, 2017)
"Although many studies have investigated the safety and tolerability of ibuprofen or acetaminophen (paracetamol) use in children, few have specifically examined the association of ibuprofen or acetaminophen and the occurrence of asthma in pediatric populations."	4.84	A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. ( Dale, S; Kanabar, D; Rawat, M, 2007)
"This paper describes two studies in children with fever in which the safety of ibuprofen was compared with that of paracetamol."	4.82	The safety of ibuprofen suspension in children. ( Lesko, SM, 2003)
" For asthma, albuterol was reported most frequently (77."	3.88	Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. ( Ansari, S; Bandoli, G; Chambers, CD; Hulugalle, A; Kuo, GM; Palmsten, K; Xu, R, 2018)
"To investigate the association between ibuprofen use and pulmonary function in children with Asthma."	3.81	Short-term ibuprofen treatment and pulmonary function in children with asthma. ( Huang, CS; Su, YM; Wan, KS, 2015)
"Unadjusted models showed an increased asthma risk in early childhood for higher infant acetaminophen (odds ratio [OR], 1."	3.81	Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. ( Bunyavanich, S; Camargo, CA; Gillman, MW; Gold, DR; Litonjua, AA; Rifas-Shiman, SL; Scirica, CV; Sordillo, JE; Weiss, ST, 2015)
"Aspirin-sensitive asthma, aspirin-intolerant asthma, aspirin- (or non-steroidal anti-inflammatory drug [NSAID]) exacerbated respiratory disease are terms for a disorder commonly described as affecting adults aged > 30y."	3.73	A teenager with severe asthma exacerbation following ibuprofen. ( Palmer, GM, 2005)
"We describe the case of a 40 year old woman, who had suffered from asthma since infancy, with a negative case history of asthma induced by aspirin or nonsteroidal anti-inflammatory (NSAID) agents, who died after ingesting 400 mg of ibuprofen."	3.69	Asthma death induced by ibuprofen. ( Antonicelli, L; Tagliabracci, A, 1995)
"A case of an adverse reaction occurring in a 53-year-old, aspirin-sensitive asthmatic male with nasal polyps following administration of a 400-mg ibuprofen tablet is reported."	3.66	Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report. ( Merritt, GJ; Selle, RI, 1978)
"Eighteen patients with asthma and aspirin hypersensitivity have been challenged with increasing doses of aspirin, fenoprofen, ibuprofen, and dextropropoxyphene."	3.65	Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. ( Czerniawska-Mysik, G; Gryglewski, RJ; Szczeklik, A; Zmuda, A, 1976)
" However, adverse effects should be taken into account in the choice between ibuprofen and acetaminophen."	2.44	[Ibuprofen in childhood: evidence-based review of efficacy and safety]. ( Cosson, MA; Landre-Peigne, C; Leroy, S; Mosca, A; Pons, G, 2007)
"Ibuprofen use was significantly lower in children diagnosed with wheezing (n = 22, 52."	1.46	Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. ( Elizur, A; Ganor, S; Kozer, E; Levine, H; Matok, I; Perlman, A, 2017)

Research

Studies (52)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Asthma Control Days

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (17.31)	18.7374
1990's	3 (5.77)	18.2507
2000's	16 (30.77)	29.6817
2010's	20 (38.46)	24.3611
2020's	4 (7.69)	2.80

Authors	Studies
Tan, E	2
Hoare, K	2
Riley, J	3
Fernando, K	1
Haskell, L	1
McKinlay, CJ	1
Dalziel, SR	3
Braithwaite, I	3
Sherbash, M	1
Furuya-Kanamori, L	1
Nader, JD	1
Thalib, L	1
McKinlay, C	1
Okesene-Gafa, K	1
Semprini, A	1
Sheridan, N	1
Grant, C	1
Johnson, D	1
Weatherall, M	2
Asher, I	1
Beasley, R	2
Sheehan, WJ	3
Paul, IM	2
Mauger, DT	2
Moy, JN	2
Szefler, SJ	2
Jackson, DJ	2
Fitzpatrick, AM	2
Cabana, MD	2
Covar, R	2
Robison, RG	2
Phipatanakul, W	3
de Martino, M	1
Chiarugi, A	1
Boner, A	1
Montini, G	1
De' Angelis, GL	1
Palmsten, K	1
Hulugalle, A	1
Bandoli, G	1
Kuo, GM	1
Ansari, S	1
Xu, R	1
Chambers, CD	1
Wurth, M	1
Papantonakis, CM	1
Nevel, RJ	1
Thomas, CS	1
Sokolow, AG	1
Moore, PE	1
Rosas-Salazar, C	1
Heinzl, S	1
Thapa, SS	1
Scott, J	1
Sánchez-Borges, M	1
Park, HS	1
Sordillo, JE	1
Scirica, CV	1
Rifas-Shiman, SL	1
Gillman, MW	1
Bunyavanich, S	1
Camargo, CA	1
Weiss, ST	1
Gold, DR	1
Litonjua, AA	1
Shaheen, SO	1
Su, YM	1
Huang, CS	1
Wan, KS	1
King, G	1
Byrne, A	1
Fleming, P	1
Boehmer, SJ	1
Bacharier, LB	1
Holguin, F	1
Lemanske, RF	1
Martinez, FD	1
Pongracic, JA	1
Beigelman, A	1
Baxi, SN	1
Benson, M	1
Blake, K	1
Chmiel, JF	1
Daines, CL	1
Daines, MO	1
Gaffin, JM	1
Gentile, DA	1
Gower, WA	1
Israel, E	1
Kumar, HV	1
Lang, JE	1
Lazarus, SC	1
Lima, JJ	1
Ly, N	1
Marbin, J	1
Morgan, WJ	1
Myers, RE	1
Olin, JT	1
Peters, SP	1
Raissy, HH	1
Ross, K	1
Sorkness, CA	1
Thyne, SM	1
Wechsler, ME	1
Mayor, S	1
Venkatesan, P	1
Hunt, A	1
McDouall, A	1
Waqanivavalagi, S	1
Stanley, T	1
Mitchell, EA	1
Matok, I	1
Elizur, A	1
Perlman, A	1
Ganor, S	1
Levine, H	1
Kozer, E	1
Uzoigwe, CE	1
Ali, OH	1
Haines, DD	1
Varga, B	1
Bak, I	1
Juhasz, B	1
Mahmoud, FF	1
Kalantari, H	1
Gesztelyi, R	1
Lekli, I	1
Czompa, A	1
Tosaki, A	1
Olze, H	1
Lau, S	1
Förster, U	1
Selbst, SM	1
Osterhoudt, K	1
Lesko, SM	3
Rosado, A	1
Vives, R	1
González, R	1
Rodríguez, J	1
South, M	1
Kader, A	1
Hildebrandt, T	1
Powell, C	1
Kauffman, RE	1
Lieh-Lai, M	1
Body, R	1
Potier, K	1
Palmer, GM	1
Debley, JS	1
Carter, ER	1
Gibson, RL	1
Rosenfeld, M	1
Redding, GJ	1
Kidon, MI	1
Kang, LW	1
Chin, CW	1
Hoon, LS	1
See, Y	1
Goh, A	1
Lin, JT	1
Chay, OM	1
Dreyfus, DH	1
Randolph, CC	1
Leroy, S	1
Mosca, A	1
Landre-Peigne, C	1
Cosson, MA	1
Pons, G	1
Kanabar, D	2
Dale, S	1
Rawat, M	1
Sharma, SK	1
Antonicelli, L	1
Tagliabracci, A	1
Kroegel, C	1
Matthys, H	1
Mitchell, AA	2
Kawai, K	1
Shirai, T	1
Suzuki, K	1
Chida, K	1
Nakamura, H	1
Goraya, JS	1
Virdi, VS	1
Louik, C	1
Vezina, RM	1
Kordansky, D	1
Adkinson, NF	1
Norman, PS	1
Rosenthal, RR	1
Merritt, GJ	1
Selle, RI	1
Szczeklik, A	1
Gryglewski, RJ	1
Czerniawska-Mysik, G	1
Zmuda, A	1
Andersen, JS	1
Guldager, H	1
Ayres, JG	1
Fleming, DM	1
Whittington, RM	1
Mathur, SL	1
Watts, MJ	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Acetaminophen vs. Ibuprofen in Children With Asthma[NCT01606319]	Phase 3	300 participants (Actual)	Interventional	2013-02-28	Completed
Astaxanthin Effects on Osteoarthritis Associated Pain and Inflammatory Indicators[NCT03664466]		0 participants (Actual)	Interventional	2021-04-29	Withdrawn (stopped due to Inadequate funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

proportion of study days on which asthma was controlled, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Asthma Rescue Medication Use

Intervention	proportion of days (Mean)
Acetaminophen	.86
Ibuprofen	.87

average albuterol rescue use per week, measured by electronic diary (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Exacerbation Frequency

Intervention	inhalations per week (Mean)
Acetaminophen	2.8
Ibuprofen	3

the number of asthma exacerbations requiring systemic corticosteroids (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Health Care Utilization

Intervention	asthma exacerbations per 46 weeks (Mean)
Acetaminophen	0.81
Ibuprofen	.87

frequency of unscheduled physician visits, emergency department visits or hospitalizations for asthma (NCT01606319)
Timeframe: last 46 weeks of 48 week treatment period

Article	Year
Risk of wheezing and asthma exacerbation in children treated with paracetamol versus ibuprofen: a systematic review and meta-analysis of randomised controlled trials. BMC pulmonary medicine, 2020, Mar-23, Volume: 20, Issue:1 Topics: Acetaminophen; Asthma; Child; Disease Progression; Humans; Ibuprofen; Randomized Controlled Trials a	2020
Working Towards an Appropriate Use of Ibuprofen in Children: An Evidence-Based Appraisal. Drugs, 2017, Volume: 77, Issue:12 Topics: Abnormalities, Multiple; Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cerebellar Di	2017
The safety of ibuprofen suspension in children. International journal of clinical practice. Supplement, 2003, Issue:135 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev	2003
How safe is ibuprofen in febrile asthmatic children? Archives of disease in childhood, 2004, Volume: 89, Issue:9 Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child, Preschool; Contrai	2004
Ibuprofen and increased morbidity in children with asthma: fact or fiction? Paediatric drugs, 2004, Volume: 6, Issue:5 Topics: Asthma; Child; Humans; Ibuprofen; Morbidity	2004
Best evidence topic report. Non-steroidal anti-inflammatory drugs and exacerbations of asthma in children. Emergency medicine journal : EMJ, 2004, Volume: 21, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Emergencies; Fever; Humans; Ibuprofen; Male	2004
[Ibuprofen in childhood: evidence-based review of efficacy and safety]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2007, Volume: 14, Issue:5 Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chickenpox; Child; Gastrointes	2007
A review of ibuprofen and acetaminophen use in febrile children and the occurrence of asthma-related symptoms. Clinical therapeutics, 2007, Volume: 29, Issue:12 Topics: Acetaminophen; Algorithms; Analgesics, Non-Narcotic; Asthma; Child; Fever; Hospitalization; Humans;	2007
Ibuprofen and asthma in paediatric populations: clinical concern or clinical reality? Journal of the Royal Society of Medicine, 2007, Volume: 100 Suppl 48 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Cyclooxygenase Inhibitors; Hu	2007

Article	Year
Panic or peace - prioritising infant welfare when medicating feverish infants: a grounded theory study of adherence in a paediatric clinical trial. BMC pediatrics, 2022, 04-11, Volume: 22, Issue:1 Topics: Acetaminophen; Asthma; Fever; Grounded Theory; Humans; Ibuprofen; Infant; Infant Welfare	2022
Randomised controlled trial of paracetamol or ibuprofen, as required for fever and pain in the first year of life, for prevention of asthma at age 6 years: paracetamol or ibuprofen in the primary prevention of asthma in Tamariki (PIPPA Tamariki) protocol. BMJ open, 2020, 12-10, Volume: 10, Issue:12 Topics: Acetaminophen; Asthma; Child; Child, Preschool; Humans; Ibuprofen; Infant; Infant, Newborn; Multicen	2020
Adherence rates during a randomized controlled trial evaluating the use of blinded acetaminophen and ibuprofen in children with asthma. Contemporary clinical trials, 2021, Volume: 104 Topics: Acetaminophen; Asthma; Child; Double-Blind Method; Humans; Ibuprofen	2021
[In process]. Medizinische Monatsschrift fur Pharmazeuten, 2016, Volume: 39, Issue:10 Topics: Acetaminophen; Asthma; Child, Preschool; Disease Progression; Fever; Humans; Ibuprofen; Pain; Prospe	2016
Acetaminophen versus Ibuprofen in Young Children with Mild Persistent Asthma. The New England journal of medicine, 2016, Aug-18, Volume: 375, Issue:7 Topics: Acetaminophen; Asthma; Child, Preschool; Double-Blind Method; Female; Fever; Humans; Ibuprofen; Inci	2016
Pilot study of feasibility of a randomised controlled trial of asthma risk with paracetamol versus ibuprofen use in infancy. The New Zealand medical journal, 2016, Oct-14, Volume: 129, Issue:1443 Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Female; Humans; Ibuprofen; Infant; Infant, Newborn;	2016
The prevalence of ibuprofen-sensitive asthma in children: a randomized controlled bronchoprovocation challenge study. The Journal of pediatrics, 2005, Volume: 147, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchial Provocation Tests; Child; Double-Blind Me	2005
The safety of acetaminophen and ibuprofen among children younger than two years old. Pediatrics, 1999, Volume: 104, Issue:4 Topics: Acetaminophen; Acute Disease; Analgesics, Non-Narcotic; Asthma; Bronchiolitis; Double-Blind Method;	1999
Asthma morbidity after the short-term use of ibuprofen in children. Pediatrics, 2002, Volume: 109, Issue:2 Topics: Acetaminophen; Age Factors; Ambulatory Care; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non	2002
Asthma improved by nonsteroidal anti-inflammatory drugs. Annals of internal medicine, 1978, Volume: 88, Issue:4 Topics: Airway Resistance; Anti-Inflammatory Agents; Aspirin; Asthma; Clinical Trials as Topic; Female; Forc	1978

Article	Year
Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. Paediatric and perinatal epidemiology, 2018, Volume: 32, Issue:1 Topics: Adult; Albuterol; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; Et	2018
Risk Factors Associated with Asthma Development and Control in Children. Mouse Infestation, Antipyretics, Respiratory Viruses, and Allergic Sensitization. American journal of respiratory and critical care medicine, 2017, 12-15, Volume: 196, Issue:12 Topics: Acetaminophen; Allergens; Animals; Antipyretics; Asthma; Child; Humans; Hypersensitivity; Ibuprofen;	2017
Double pylorus. BMJ case reports, 2018, Sep-04, Volume: 2018 Topics: Aged; Analgesics, Non-Narcotic; Asthma; Back Pain; Duodenal Diseases; Endoscopy; Gastric Fistula; Ga	2018
NSAID Hypersensitivity. The journal of allergy and clinical immunology. In practice, 2019, Volume: 7, Issue:2 Topics: Allergens; Angioedema; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Disease Progression; Drug Hy	2019
Prenatal and infant exposure to acetaminophen and ibuprofen and the risk for wheeze and asthma in children. The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Chi	2015
Acetaminophen and childhood asthma: pill-popping at our peril? The Journal of allergy and clinical immunology, 2015, Volume: 135, Issue:2 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Female; Hu	2015
Short-term ibuprofen treatment and pulmonary function in children with asthma. Indian pediatrics, 2015, Volume: 52, Issue:8 Topics: Asthma; Breath Tests; Case-Control Studies; Child; Female; Forced Expiratory Volume; Humans; Ibuprof	2015
A case of severe NSAID exacerbated respiratory disease (NERD) following a dental procedure in a child. European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry, 2016, Volume: 17, Issue:4 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Cyclooxygenase 2 Inhibitors; Drug Hyper	2016
Paracetamol is no more likely to exacerbate asthma in children than ibuprofen, shows study. BMJ (Clinical research ed.), 2016, 08-17, Volume: 354 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Fev	2016
Paracetamol no worse than ibuprofen in children with mild asthma. The Lancet. Respiratory medicine, 2016, Volume: 4, Issue:10 Topics: Acetaminophen; Asthma; Child; Child, Preschool; Disease Progression; Female; Humans; Ibuprofen; Male	2016
Association of Acetaminophen and Ibuprofen Use With Wheezing in Children With Acute Febrile Illness. The Annals of pharmacotherapy, 2017, Volume: 51, Issue:3 Topics: Acetaminophen; Analgesics, Non-Narcotic; Antipyretics; Asthma; Child; Child, Preschool; Cross-Sectio	2017
Acetaminophen versus Ibuprofen in Mild Persistent Asthma. The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;	2016
Acetaminophen versus Ibuprofen in Mild Persistent Asthma. The New England journal of medicine, 2016, 11-24, Volume: 375, Issue:21 Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Double-Blind Method; Fever; Humans;	2016
Summative interaction between astaxanthin, Ginkgo biloba extract (EGb761) and vitamin C in suppression of respiratory inflammation: a comparison with ibuprofen. Phytotherapy research : PTR, 2011, Volume: 25, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Ascorbic Acid; Asthma; Drug Therapy, Combination; Ginkgo biloba;	2011
Samter's triad and eicosanoid imbalance in children with recurrent nasal polyps. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2012, Volume: 23, Issue:5 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Child; Diclofenac; Drug Hypersensitivit	2012
Pediatric emergency medicine: legal briefs. Pediatric emergency care, 2012, Volume: 28, Issue:12 Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Appendicitis;	2012
Can NSAIDs intolerance disappear? A study of three cases. Allergy, 2003, Volume: 58, Issue:7 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Drug Hypersensitivity; Forced Expir	2003
Pain relievers and asthma. Pediatrics, 2003, Volume: 112, Issue:6 Pt 1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Asthma; Child; Humans; Ibuprofen; Morbidity; Risk	2003
A teenager with severe asthma exacerbation following ibuprofen. Anaesthesia and intensive care, 2005, Volume: 33, Issue:2 Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asthma; Contraindications; Humans; Ibu	2005
Early presentation with angioedema and urticaria in cross-reactive hypersensitivity to nonsteroidal antiinflammatory drugs among young, Asian, atopic children. Pediatrics, 2005, Volume: 116, Issue:5 Topics: Acetaminophen; Administration, Oral; Adolescent; Allergens; Angioedema; Anti-Inflammatory Agents, No	2005
Characterization of an anaphylactoid reaction to omalizumab. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 96, Issue:4 Topics: Adult; Anaphylaxis; Angioedema; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agent	2006
Ibuprofen (Brufen) induced bronchial asthma. The Journal of the Association of Physicians of India, 1984, Volume: 32, Issue:9 Topics: Asthma; Drug Hypersensitivity; Headache; Humans; Ibuprofen	1984
[Prevention of food hypersensitivities with aspirin]. MMW, Munchener medizinische Wochenschrift, 1980, Jul-18, Volume: 122, Issue:29 Topics: Animals; Arachidonic Acids; Aspirin; Asthma; Food Hypersensitivity; Ibuprofen; Indomethacin; Milk; P	1980
Asthma death induced by ibuprofen. Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace, 1995, Volume: 50, Issue:4 Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Apnea; Asthma; Fatal Outcome; Female; Humans; Ibupro	1995
Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics. Immunology, 1993, Volume: 78, Issue:2 Topics: Asthma; Cells, Cultured; Dose-Response Relationship, Drug; Eosinophils; Humans; Ibuprofen; Leukocyte	1993
[Mild intermittent aspirin-induced asthma in a patient who became asymptomatic after removal of pet hamsters from home]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2000, Volume: 38, Issue:4 Topics: Adult; Allergens; Animals; Animals, Domestic; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Asth	2000
To the editor: Exacerbation of asthma by ibuprofen in a very young child. Pediatric pulmonology, 2001, Volume: 32, Issue:3 Topics: Albuterol; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchodilator Agents; Child, Preschool;	2001
Cross-reactivity between aspirin and ibuprofen in an asthmatic--a case report. American journal of hospital pharmacy, 1978, Volume: 35, Issue:10 Topics: Aspirin; Asthma; Cross Reactions; Drug Hypersensitivity; Humans; Ibuprofen; Male; Middle Aged	1978
Aspirin-induced asthma. Hypersensitivity to fenoprofen and ibuprofen in relation to their inhibitory action on prostaglandin generation by different microsomal enzymic preparations. The Journal of allergy and clinical immunology, 1976, Volume: 58, Issue:1 PT 1 Topics: Adolescent; Adult; Aspirin; Asthma; Constriction, Pathologic; Dextropropoxyphene; Drug Hypersensitiv	1976
[Ibuprofen triggered asthma attack in a patient with known aspirin hypersensitivity]. Ugeskrift for laeger, 1989, Jul-17, Volume: 151, Issue:29 Topics: Aged; Aspirin; Asthma; Drug Hypersensitivity; Humans; Ibuprofen; Male	1989
Asthma death due to ibuprofen. Lancet (London, England), 1987, May-09, Volume: 1, Issue:8541 Topics: Acute Disease; Aged; Albuterol; Asthma; Beclomethasone; Drug Interactions; Female; Humans; Ibuprofen	1987
Ibuprofen in bronchial asthma. The Journal of the Association of Physicians of India, 1988, Volume: 36, Issue:8 Topics: Adult; Asthma; Female; Humans; Ibuprofen; Male; Status Asthmaticus	1988
Ibuprofen and asthma. British dental journal, 1987, Jan-24, Volume: 162, Issue:2 Topics: Aged; Asthma; Female; Humans; Ibuprofen; Status Asthmaticus	1987

ibuprofen and Asthma