ibuprofen has been researched along with Arthritis, Rheumatoid in 216 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In doses of 1,200 mg/day or more, ibuprofen is as effective as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of rheumatoid arthritis." | 10.15 | Update on ibuprofen for rheumatoid arthritis. ( Ward, JR, 1984) |
| "To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis." | 9.11 | Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004) |
| " This study sought to evaluate dyspepsia-related health in osteoarthritis (OA) and rheumatoid arthritis (RA) patients taking valdecoxib compared with patients taking nonspecific NSAIDs." | 9.11 | Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis. ( Goldstein, JL; Mayne, TJ; Rabeneck, L; Rublee, DA; Vu, A, 2005) |
| "We compared the longterm efficacy and safety of 2 dosages of etodolac with that of ibuprofen in the treatment of active rheumatoid arthritis (RA)." | 9.08 | Double blind evaluation of the long-term effects of etodolac versus ibuprofen in patients with rheumatoid arthritis. ( Neustadt, DH, 1997) |
| "The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients." | 9.07 | Investigation into the duration of action of sustained-release ibuprofen in osteoarthritis and rheumatoid arthritis. ( Fernandes, L; Jenkins, R, 1994) |
| " Patients suffering from rheumatoid arthritis received oral doses of 600 mg racemic ibuprofen (n = 25; RAC) or 400 mg (S)-ibuprofen (n = 25; S-IBU) in a double-blind, randomized parallel-group study." | 9.07 | Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis. ( Bach, GL; Brune, K; Geisslinger, G; Loew, D; Stock, KP, 1993) |
| "The efficacy of nabumetone was compared with that of diclofenac, naproxen, ibuprofen, and piroxicam in patients with osteoarthritis (OA) or rheumatoid arthritis (RA) in a randomized, controlled, open-label, multicenter trial." | 9.07 | Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. ( DeLapp, RE; Lister, BJ; Poland, M, 1993) |
| " The effects were studied of one week of treatment of rheumatoid arthritis patients with suprofen or ibuprofen on Na+ and K+ excretion, creatinine clearance, urinary enzymes that are markers for tubular damage, and urinary prostaglandins such as PGE2 and 6-keto PGF1 alpha (a stable metabolite of prostacyclin)." | 9.06 | Effects of suprofen on renal function in patients with rheumatoid arthritis. ( Angelini, M; Baldini, L; Barenghi, L; Borsa, M; Carrabba, M; Ceriotti, F; Malandrino, S; Tonon, GC, 1987) |
| "Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations." | 9.06 | Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986) |
| "Diflunisal, a nonacetylated salicylate preparation with a prolonged duration of action, was compared with ibuprofen for the treatment of rheumatoid arthritis in a multicenter trial comprising 210 patients." | 9.06 | A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis. ( Bennett, RM, 1986) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 9.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Piroxicam was compared with ibuprofen in a 8 weeks randomised open clinical trial in 31 patients (16 patients with piroxicam and 15 patients with ibuprofen) with rheumatoid arthritis." | 9.05 | Comparative study of piroxicam and ibuprofen in rheumatoid arthritis. ( Alam, MN; Kabir, MZ, 1983) |
| "Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial." | 9.05 | Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial. ( Ferry, DG; Gibbins, BL; Grennan, DM; Hall, SM; Lum, J; Myers, DB; Palmer, DG, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 9.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "A double-blind study compared choline magnesium trisalicylate (Trilisate tablets, Purdue Frederick) (CMT) and ibuprofen (IPF) in the treatment of rheumatoid arthritis." | 9.05 | Choline magnesium trisalicylate versus ibuprofen in rheumatoid arthritis. ( Ehrlich, GE; Miller, SB; Zeiders, RS, 1980) |
| "A single-blind, crossover trial was carried out in 30 rheumatoid arthritis patients to compare the effectiveness and tolerance of 250 mg naproxen, 400 mg ibuprofen and 25 mg indomethacin twice daily in patients treated concurrently with a night-time 500 mg naproxen suppository." | 9.05 | Naproxen suppositories in combination with oral naproxen, indomethacin and ibuprofen in the treatment of rheumatoid arthritis. ( Engler, C; Seifert, MH, 1980) |
| " The maximum recommended dosage for ibuprofen, a widely prescribed drug for the treatment of rheumatoid arthritis, has increased from 400 mg three or four times a day (at the time of its introduction) to 2,400 mg per day at present." | 9.05 | A double-blind comparative study of piroxicam and ibuprofen in the treatment of rheumatoid arthritis. ( McLaughlin, GE, 1985) |
| "Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day)." | 9.04 | A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthritis. ( Hearron, MS; Miyara, A; Moxley, TE; Royer, GL; Shenker, BM, 1975) |
| "Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen." | 9.04 | Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis. ( Coomes, EN; Darlington, LG, 1975) |
| "Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis." | 9.04 | Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen. ( Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J, 1977) |
| "A double-blind parallel multi-centre study of 102 patients with rheumatoid arthritis (RA) was performed, comparing ibuprofen (1200-2400 mg daily) and ketoprofen (150-300 mg daily) a new non-steroidal, anti-inflammatory agent, over a three month period." | 9.04 | Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis. ( Bennett, RM; Calin, A; Giuliano, VJ; Goldman, AL; Montoya, HE; O'Brien, WM; Sakofsky, HY; Schmid, FR; Sukhupunyaraksa, S; Willkens, RF, 1977) |
| "A randomized double-blind within-patient study of mefenamic acid compared with ibuprofen was performed on forty patients with rheumatoid arthritis." | 9.04 | Mefenamic acid compared with ibuprofen in the treatment of rheumatoid arthritis. ( Leslie, RD, 1977) |
| "In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day)." | 9.04 | A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis. ( Fumagalli, M; Liverta, C; Montrone, F; Pellegrini, P; Pollini, C; Pontiroli, AE; Ratti, G; Sala, G, 1979) |
| "A single-blind, crossover trial was carried out in 24 patients with definite or classical rheumatoid arthritis to compare the effectiveness and tolerability of piroxicam (20 mg once daily) with that of indomethacin (25 mg 3-times daily), ibuprofen (400 mg 3-times daily) and placebo." | 9.04 | A crossover clinical trial of piroxicam, indomethacin and ibuprofen in rheumatoid arthritis. ( Balogh, Z; Buchanan, WW; MacLeod, M; Papazoglou, SN, 1979) |
| "1 This was a double-blind crossover trial of ibuprofen and soluble aspirin against each drug alone and against placebo in patients with rheumatoid arthritis." | 9.04 | The aspirin-ibuprofen interaction in rheumatoid arthritis. ( Ashworth, ME; Ferry, DG; Grennan, DM; Kenny, RE; Mackinnon, M, 1979) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 9.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "This paper reports a double-blind crossover trial comparing mefenamic acid (1500 mg/day) with ibuprofen (1200 mg/day) in the treatment of patients with rheumatoid arthritis receiving maintenance salicylate therapy." | 9.04 | Comparison of effectiveness of mefenamic acid and ibuprofen in treatment of rheumatoid arthritis. ( Muirden, KD; Stockman, A; Varigos, GA, 1976) |
| " In a year-long double-blind multiclinic trial in 885 patients with rheumatoid arthritis, ibuprofen was at least as satisfactory as aspirin, considering both efficacy and tolerance." | 9.04 | Ibuprofen or aspirin in rheumatoid arthritis therapy. ( April, PA; Blechman, WJ; Brooks, CD; Schmid, FR; Wilson, CH, 1975) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 8.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "The present study aimed to fabricate and evaluate the therapeutic efficacy of pH-responsive Ibuprofen (IB) nanoparticles (NPs) loaded transdermal hydrogel against rheumatoid arthritis (RA)." | 8.02 | Development of an intelligent, stimuli-responsive transdermal system for efficient delivery of Ibuprofen against rheumatoid arthritis. ( Ahmed, N; Asad, MI; Khan, D; Qindeel, M; Shah, KU, 2021) |
| "Single-tablet ibuprofen/famotidine is approved by the US Food and Drug Administration for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal (GI) ulcers in patients taking ibuprofen for those indications." | 7.79 | Budget impact modeling for a single-tablet formulation of ibuprofen and famotidine for prevention of upper gastrointestinal ulcers in patients with osteoarthritis and/or rheumatoid arthritis. ( Holt, RJ; Johnson, KE; Kent, JD; Kuan, R; Malone, D; Peura, DA, 2013) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 7.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen." | 7.69 | Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. ( Horn, AC; Jarrett, SW, 1997) |
| "We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment)." | 7.68 | The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. ( Bradley, JD; Brater, DC; Hall, SD; Jones, DR; Krohn, K; Tracy, TS, 1992) |
| "Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis." | 7.66 | Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis. ( Bremova, A; Kankova, D; Kralova, M; Pavelka, K; Susta, A; Vojtisek, O, 1978) |
| " Adverse events (AEs) were collected beginning at the first dose and continued through completion (54 weeks)." | 6.80 | One-year open-label safety evaluation of the fixed combination of ibuprofen and famotidine with a prospective analysis of dyspepsia. ( Ball, J; Bello, AE; Grahn, AY; Holt, RJ; Kent, JD, 2015) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 6.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| "The subsequent development of mechanical hyperalgesia to pinprick stimuli was then measured at various time points using a 74." | 6.68 | Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. ( Cruwys, SC; Kidd, BL; Morris, VH, 1997) |
| "Naproxen-treated patients experienced significantly (p < 0." | 6.67 | Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. ( DeLapp, RE; Eversmeyer, W; Jensen, CP; Poland, M, 1993) |
| "Ibuprofen (ibu) is a racemic 2-arylpropionic acid non-steroidal anti-inflammatory drug whose activity is due mainly to the S-enantiomer." | 6.67 | S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis. ( Bach, GL; Beck, WS; Brune, K; Geisslinger, G; Loew, D; Stock, KP, 1991) |
| "In doses of 1,200 mg/day or more, ibuprofen is as effective as aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of rheumatoid arthritis." | 6.15 | Update on ibuprofen for rheumatoid arthritis. ( Ward, JR, 1984) |
| "Carbon monoxide (CO) is a gas endogenously produced in humans, reported to exhibit anti-inflammatory and cytoprotective effects at low concentration." | 5.51 | Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. ( Angeli, A; Bartolucci, G; Berrino, E; Bozdag, M; Carta, F; di Cesare Mannelli, L; Ghelardini, C; Menicatti, M; Micheli, L; Milazzo, L; Nocentini, A; Supuran, CT; Vullo, D, 2019) |
| "Twenty-four thousand eighty-one patients who required NSAIDs for osteoarthritis or rheumatoid arthritis (RA) and had increased CV risk randomly received celecoxib, ibuprofen, or naproxen." | 5.51 | Cardiorenal risk of celecoxib compared with naproxen or ibuprofen in arthritis patients: insights from the PRECISION trial. ( Bao, W; Davey, DA; Husni, E; Libby, P; Lüscher, TF; Nissen, SE; Obeid, S; Ruschitzka, F; Walker, C; Wang, Q; Wisniewski, LM; Wolski, KE; Xia, F, 2022) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 5.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| "S(+)-ibuprofen proved to be an effective analgesic antirheumatic drug in the dose range 1 to 1." | 5.28 | Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis. ( Bach, GL; Brune, K; Geisslinger, G; Loew, D; Schuster, O; Stock, KP, 1990) |
| "To determine the relative risks of cardiovascular (CV), gastrointestinal (GI), and renal adverse events during long-term treatment with celecoxib, compared with ibuprofen and naproxen, in patients with osteoarthritis (OA) and patients with rheumatoid arthritis (RA)." | 5.27 | Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis: A Randomized Clinical Trial. ( Bao, W; Berger, MF; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Solomon, DH; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2018) |
| " Osteoarthritis or rheumatoid arthritis patients, needing ongoing NSAID treatment, were randomised to receive celecoxib 100-200 mg b." | 5.27 | Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial. ( Bao, W; Borer, JS; Graham, DY; Husni, ME; Libby, P; Lincoff, AM; Lüscher, TF; Nissen, SE; Solomon, DH; Stevens, T; Vargo, J; Walker, C; Wang, Q; Wisniewski, LM; Wolski, KE; Yeomans, ND, 2018) |
| " Pharmacokinetic variables probably account for only a small part of the inter-individual variation in response of rheumatoid patients treated with increasing dosages of the non-steroidal, anti-inflammatory drug ibuprofen." | 5.27 | Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings. ( Aarons, L; Grennan, DM; Higham, C; Richards, M; Siddiqui, M; Thompson, R, 1983) |
| "In this double-blind, randomized, multicentre non-inferiority CV-safety trial, 444 patients (mean age 62 ± 10 years, 54% female) with osteoarthritis (92%) or rheumatoid arthritis (8%) and evidence of or at increased risk for coronary artery disease received celecoxib (100-200 mg bid), ibuprofen (600-800 mg tid), or naproxen (375-500 mg bid) with matching placebos in a 1: 1: 1 allocation, to assess the effect on 24-h ambulatory BP after 4 months." | 5.24 | Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) ( Beckerman, B; Borer, JS; Davey, DA; Fayyad, R; Flammer, AJ; Graham, DY; Husni, ME; Iorga, D; Krum, H; Libby, P; Lincoff, AM; Lüscher, TF; Menon, V; Nissen, SE; Ruschitzka, F; Solomon, DH; Wisniewski, LM; Yeomans, ND, 2017) |
| "In the pivotal efficacy and safety trials, discontinuation rates due to any cause and dyspepsia were significantly lower for the ibuprofen/famotidine combination versus ibuprofen alone." | 5.20 | One-year safety of ibuprofen/famotidine fixed combination versus ibuprofen alone: pooled analyses of two 24-week randomized, double-blind trials and a follow-on extension. ( Ball, J; Bello, AE; Grahn, AY; Holt, RJ; Kent, JD, 2015) |
| "The cardiorenal safety database from the Celecoxib Long-term Arthritis Safety Study (CLASS) was analyzed to examine whether supratherapeutic doses of celecoxib are associated with decreased renal function and blood pressure (BP) effects compared with standard doses of diclofenac and ibuprofen in osteoarthritis (OA) and rheumatoid arthritis (RA) patients." | 5.12 | Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen. ( Lefkowith, JL; Verburg, KM; West, CR; Whelton, A, 2006) |
| "To compare the gastroduodenal safety of lumiracoxib with ibuprofen and celecoxib in patients with rheumatoid arthritis." | 5.11 | Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis. ( Gimona, A; Hawkey, C; Kivitz, AJ; Nayiager, S; Schimansky, T; Thurston, HJ, 2004) |
| " This study sought to evaluate dyspepsia-related health in osteoarthritis (OA) and rheumatoid arthritis (RA) patients taking valdecoxib compared with patients taking nonspecific NSAIDs." | 5.11 | Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis. ( Goldstein, JL; Mayne, TJ; Rabeneck, L; Rublee, DA; Vu, A, 2005) |
| "We compared the longterm efficacy and safety of 2 dosages of etodolac with that of ibuprofen in the treatment of active rheumatoid arthritis (RA)." | 5.08 | Double blind evaluation of the long-term effects of etodolac versus ibuprofen in patients with rheumatoid arthritis. ( Neustadt, DH, 1997) |
| "The duration of action of sustained-release ibuprofen ('Brufen Retard') was investigated in a 14-day double-blind study involving 14 osteoarthritis and 10 rheumatoid arthritis patients." | 5.07 | Investigation into the duration of action of sustained-release ibuprofen in osteoarthritis and rheumatoid arthritis. ( Fernandes, L; Jenkins, R, 1994) |
| " Patients suffering from rheumatoid arthritis received oral doses of 600 mg racemic ibuprofen (n = 25; RAC) or 400 mg (S)-ibuprofen (n = 25; S-IBU) in a double-blind, randomized parallel-group study." | 5.07 | Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis. ( Bach, GL; Brune, K; Geisslinger, G; Loew, D; Stock, KP, 1993) |
| "In a randomized, open-label, controlled, multicenter, 12-week study, the efficacy and safety of nabumetone (1,000-2,000 mg/day) versus diclofenac (100-200 mg/day), naproxen (500-1,500 mg/day), ibuprofen (1,200-3,200 mg/day), or piroxicam (10-20 mg/day) were evaluated in patients with osteoarthritis (OA) or rheumatoid arthritis (RA)." | 5.07 | Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in the elderly. ( DeLapp, RE; Morgan, GJ; Poland, M, 1993) |
| "The efficacy of nabumetone was compared with that of diclofenac, naproxen, ibuprofen, and piroxicam in patients with osteoarthritis (OA) or rheumatoid arthritis (RA) in a randomized, controlled, open-label, multicenter trial." | 5.07 | Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. ( DeLapp, RE; Lister, BJ; Poland, M, 1993) |
| "The objective of this study is to utilize a clinical trial based on a decision-analysis model to assess the economic benefit of a lower incidence of gastrointestinal lesions in elderly patients with osteoarthritis receiving nabumetone therapy compared with ibuprofen alone and in combination with misoprostol." | 5.07 | A decision analysis model in the evaluation of NSAIDs in a managed care setting: a case study. ( Brixner, DI, 1994) |
| "In a double-blind clinical study, the analgesic effects of ibuprofen-lysinsalt and diclofenac were compared in 59 patients with rheumatoid arthritis." | 5.06 | [The dynamics of the analgesic effect of non-steroidal antirheumatic drugs. Ibuprofenlysinate versus diclofenac]. ( Pavelka, K; Trnavsky, K, 1989) |
| " The effects were studied of one week of treatment of rheumatoid arthritis patients with suprofen or ibuprofen on Na+ and K+ excretion, creatinine clearance, urinary enzymes that are markers for tubular damage, and urinary prostaglandins such as PGE2 and 6-keto PGF1 alpha (a stable metabolite of prostacyclin)." | 5.06 | Effects of suprofen on renal function in patients with rheumatoid arthritis. ( Angelini, M; Baldini, L; Barenghi, L; Borsa, M; Carrabba, M; Ceriotti, F; Malandrino, S; Tonon, GC, 1987) |
| "Diclofenac sodium is a nonsteroidal, anti-inflammatory drug that has been studied in the United States for the treatment of rheumatoid arthritis in 681 patients, 468 of whom were enrolled in five multicenter, double-blind parallel controlled investigations." | 5.06 | Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States. ( Caldwell, JR, 1986) |
| "The incidence of potentially serious drug-related elevations of BUN or serum creatinine was examined among 1468 patients with rheumatoid arthritis or osteoarthritis who took daily therapeutic doses of aspirin, ibuprofen, or oxaprozin, an investigational nonsteroidal antiinflammatory drug (NSAID), in multicenter clinical trials." | 5.06 | Renal safety of two analgesics used over the counter: ibuprofen and aspirin. ( Bonney, SL; Hedrich, DA; Northington, RS; Walker, BR, 1986) |
| "Diflunisal, a nonacetylated salicylate preparation with a prolonged duration of action, was compared with ibuprofen for the treatment of rheumatoid arthritis in a multicenter trial comprising 210 patients." | 5.06 | A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis. ( Bennett, RM, 1986) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 5.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Diflunisal, a new nonsteroidal, Aspirin-like anti-inflammatory agent has been compared with Ibuprofen und Placebo in a six-week double-blind randomized crossover controlled study in 24 patients with rheumatoid arthritis." | 5.05 | [Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis]. ( Fasching, U, 1983) |
| "Piroxicam was compared with ibuprofen in a 8 weeks randomised open clinical trial in 31 patients (16 patients with piroxicam and 15 patients with ibuprofen) with rheumatoid arthritis." | 5.05 | Comparative study of piroxicam and ibuprofen in rheumatoid arthritis. ( Alam, MN; Kabir, MZ, 1983) |
| " Gastrointestinal side effects with benoxaprofen compared favorably to those reported during aspirin and ibuprofen therapy, with peptic ulcers reported in 0." | 5.05 | Long-term safety of benoxaprofen. ( Mikulaschek, WM, 1980) |
| "Both diflunisal (750 mg/day) and ibuprofen (1600 mg/day) were shown to be superior to placebo in the treatment of rheumatoid arthritis in a double-blind cross-over trial." | 5.05 | Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial. ( Ferry, DG; Gibbins, BL; Grennan, DM; Hall, SM; Lum, J; Myers, DB; Palmer, DG, 1981) |
| "Thirty patients with classical or definite rheumatoid arthritis were given indoprofen 800 mg/day, ibuprofen 1200 mg/day or placebo in a double-blind cross-over trial, for three consecutive 10-day periods." | 5.05 | Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients. ( Rivelis, L; Scali, JJ, 1981) |
| "A double-blind study compared choline magnesium trisalicylate (Trilisate tablets, Purdue Frederick) (CMT) and ibuprofen (IPF) in the treatment of rheumatoid arthritis." | 5.05 | Choline magnesium trisalicylate versus ibuprofen in rheumatoid arthritis. ( Ehrlich, GE; Miller, SB; Zeiders, RS, 1980) |
| "A single-blind, crossover trial was carried out in 30 rheumatoid arthritis patients to compare the effectiveness and tolerance of 250 mg naproxen, 400 mg ibuprofen and 25 mg indomethacin twice daily in patients treated concurrently with a night-time 500 mg naproxen suppository." | 5.05 | Naproxen suppositories in combination with oral naproxen, indomethacin and ibuprofen in the treatment of rheumatoid arthritis. ( Engler, C; Seifert, MH, 1980) |
| "Morning stiffness in 75 patients with mild to moderate rheumatoid arthritis was treated with 1600 mg ibuprofen 4-times daily or 750 mg naproxen twice daily after a placebo-induced flare of this symptom." | 5.05 | Relief of morning stiffness: a comparative study of naproxen and ibuprofen. ( Anderson, S; Goldberg, M; Gross, J; Kantrowitz, F; Menander-Huber, K; Taborn, J, 1985) |
| " The maximum recommended dosage for ibuprofen, a widely prescribed drug for the treatment of rheumatoid arthritis, has increased from 400 mg three or four times a day (at the time of its introduction) to 2,400 mg per day at present." | 5.05 | A double-blind comparative study of piroxicam and ibuprofen in the treatment of rheumatoid arthritis. ( McLaughlin, GE, 1985) |
| "Two-hundred and eighteen individuals with rheumatoid arthritis were randomly assigned to six months treatment with ibuprofen (900-1800 mg/day) or indomethacin (75-150 mg/day)." | 5.04 | A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthritis. ( Hearron, MS; Miyara, A; Moxley, TE; Royer, GL; Shenker, BM, 1975) |
| "Benorylate and ibuprofen appear to be useful drugs for pain relief in rheumatoid arthritis but benorylate would appear to have a slightly better effect on the pain score and it improved the grip strength more than the moderate doses of ibuprofen." | 5.04 | Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis. ( Coomes, EN; Darlington, LG, 1975) |
| "Flurbiprofen and ibuprofen were compared in a six-week double-blind randomized study in 208 patients with rheumatoid arthritis." | 5.04 | Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen. ( Briney, WG; Giansiracusa, J; Mena, HR; Ward, JR; Wolski, KP; Zuckner, J, 1977) |
| "A double-blind parallel multi-centre study of 102 patients with rheumatoid arthritis (RA) was performed, comparing ibuprofen (1200-2400 mg daily) and ketoprofen (150-300 mg daily) a new non-steroidal, anti-inflammatory agent, over a three month period." | 5.04 | Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis. ( Bennett, RM; Calin, A; Giuliano, VJ; Goldman, AL; Montoya, HE; O'Brien, WM; Sakofsky, HY; Schmid, FR; Sukhupunyaraksa, S; Willkens, RF, 1977) |
| "A randomized double-blind within-patient study of mefenamic acid compared with ibuprofen was performed on forty patients with rheumatoid arthritis." | 5.04 | Mefenamic acid compared with ibuprofen in the treatment of rheumatoid arthritis. ( Leslie, RD, 1977) |
| "The comparative efficacy and safety of naproxen and ibuprofen were studied in 64 patients with rheumatoid arthritis." | 5.04 | Drug trial in rheumatoid arthritis: a new design. ( Arendt-Racine, EC; Atkinson, MH; Decoteau, WE; Flatt, VL; Varady, J, 1978) |
| "In a double blind trial with 20 patients ibuprofen 1600 mg daily and indomethacin 100 mg daily were shown to be of comparable efficacy in the short-term treatment of rheumatoid arthritis." | 5.04 | A comparative study of indomethacin and ibuprofen. ( Ferry, DG; McArthur, AW; Palmer, DG, 1979) |
| "In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day)." | 5.04 | A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis. ( Fumagalli, M; Liverta, C; Montrone, F; Pellegrini, P; Pollini, C; Pontiroli, AE; Ratti, G; Sala, G, 1979) |
| "A single-blind, crossover trial was carried out in 24 patients with definite or classical rheumatoid arthritis to compare the effectiveness and tolerability of piroxicam (20 mg once daily) with that of indomethacin (25 mg 3-times daily), ibuprofen (400 mg 3-times daily) and placebo." | 5.04 | A crossover clinical trial of piroxicam, indomethacin and ibuprofen in rheumatoid arthritis. ( Balogh, Z; Buchanan, WW; MacLeod, M; Papazoglou, SN, 1979) |
| "1 This was a double-blind crossover trial of ibuprofen and soluble aspirin against each drug alone and against placebo in patients with rheumatoid arthritis." | 5.04 | The aspirin-ibuprofen interaction in rheumatoid arthritis. ( Ashworth, ME; Ferry, DG; Grennan, DM; Kenny, RE; Mackinnon, M, 1979) |
| "Tiaprofenic acid, 200 mg three times a day, was compared with ibuprofen, 400 mg three times a day, in 41 patients suffering from rheumatoid arthritis and already receiving nonsteroidal anti-inflammatory drugs in a double-blind controlled study." | 5.04 | A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis. ( Akbar, FA; Chestney, V; Daymond, TJ; Thompson, M, 1979) |
| "Ninety patients with rheumatoid arthritis completed a double-blind crossover trial comparing fenoprofen, ibuprofen, ketoprofen, and naproxen." | 5.04 | Four new anti-inflammatory drugs: responses and variations. ( Balme, HW; Franklin, S; Huskisson, EC; Scott, J; Woolf, DL, 1976) |
| "This paper reports a double-blind crossover trial comparing mefenamic acid (1500 mg/day) with ibuprofen (1200 mg/day) in the treatment of patients with rheumatoid arthritis receiving maintenance salicylate therapy." | 5.04 | Comparison of effectiveness of mefenamic acid and ibuprofen in treatment of rheumatoid arthritis. ( Muirden, KD; Stockman, A; Varigos, GA, 1976) |
| " In a year-long double-blind multiclinic trial in 885 patients with rheumatoid arthritis, ibuprofen was at least as satisfactory as aspirin, considering both efficacy and tolerance." | 5.04 | Ibuprofen or aspirin in rheumatoid arthritis therapy. ( April, PA; Blechman, WJ; Brooks, CD; Schmid, FR; Wilson, CH, 1975) |
| "We know from adult randomised controlled trials that some NSAIDs, such as ibuprofen, naproxen, and aspirin, can be effective in certain chronic pain conditions." | 4.95 | Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. ( Anderson, B; Cooper, TE; Eccleston, C; Fisher, E; Wilkinson, NM, 2017) |
| "Ibuprofen was the product of a long research programme during the 1950s and 1960s to develop a 'super aspirin' for the treatment of rheumatoid arthritis which was as effective as current alternatives but safer." | 4.82 | Discovery, mechanisms of action and safety of ibuprofen. ( Rainsford, KD, 2003) |
| "There is epidemiological observation that long-term treatment of patients suffering from rheumatoid arthritis with ibuprofen results in reduced risk and delayed onset of Alzheimer's disease (AD)." | 4.82 | Ibuprofen and Alzheimer's disease. ( Dokmeci, D, 2004) |
| "Celecoxib is the first COX-2-specific inhibitor approved for relief of the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), as well as for treatment of familial adenomatous polyposis." | 4.80 | Celecoxib clinical profile. ( Tive, L, 2000) |
| " Published data indicate that diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid arthritis and with indomethacin in osteoarthritis." | 4.76 | Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin. ( Avery, GS; Brogden, RN; Heel, RC; Pakes, GE; Speight, TM, 1980) |
| "The present study aimed to fabricate and evaluate the therapeutic efficacy of pH-responsive Ibuprofen (IB) nanoparticles (NPs) loaded transdermal hydrogel against rheumatoid arthritis (RA)." | 4.02 | Development of an intelligent, stimuli-responsive transdermal system for efficient delivery of Ibuprofen against rheumatoid arthritis. ( Ahmed, N; Asad, MI; Khan, D; Qindeel, M; Shah, KU, 2021) |
| "Ibuprofen is a classical nonsteroidal anti-inflammatory drug (NSAID) highly prescribed to reduce acute pain and inflammation under an array of conditions, including rheumatoid arthritis, osteoarthritis, dysmenorrhea, and gout." | 4.02 | Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases. ( Amanullah, A; Dhiman, R; Joshi, V; Mishra, A; Poluri, KM; Prajapati, VK; Upadhyay, A, 2021) |
| " For asthma, albuterol was reported most frequently (77." | 3.88 | Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma. ( Ansari, S; Bandoli, G; Chambers, CD; Hulugalle, A; Kuo, GM; Palmsten, K; Xu, R, 2018) |
| "In the therapy of rheumatoid arthritis, ibuprofen (IBU) is widely used; however, it has been limited the clinical use by its systemic side effect, such as gastrointestinal lesions." | 3.83 | Pharmacokinetic Studies of Gel System Containing Ibuprofen Solid Nanoparticles. ( Ito, Y; Nagai, N; Tanino, T, 2016) |
| "Single-tablet ibuprofen/famotidine is approved by the US Food and Drug Administration for the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis and to decrease the risk of developing upper gastrointestinal (GI) ulcers in patients taking ibuprofen for those indications." | 3.79 | Budget impact modeling for a single-tablet formulation of ibuprofen and famotidine for prevention of upper gastrointestinal ulcers in patients with osteoarthritis and/or rheumatoid arthritis. ( Holt, RJ; Johnson, KE; Kent, JD; Kuan, R; Malone, D; Peura, DA, 2013) |
| "We investigated the anti-inflammatory activities of argirein and rhein on inflammatory edema in rat paw which was caused by complete adjuvant, compared with ibuprofen." | 3.78 | ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats. ( Cong, XD; Dai, DZ; Dai, Y; Ding, MJ; Wu, Y; Zhang, Y, 2012) |
| "The FDA has approved Duexis (Horizon), a fixed-dose combination of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen and the H2-receptor antagonist (H2RA) famotidine, for symptomatic relief of osteoarthritis and rheumatoid arthritis and to decrease the risk of developing gastric and duodenal ulcers in patients at risk for NSAID-associated ulcers." | 3.77 | A fixed-dose combination ibuprofen and famotidine (Duexis). ( , 2011) |
| "Ibuprofen was the first of a new breed of NSAIDs originally introduced into the United Kingdom in 1969." | 3.76 | Update on ibuprofen: review article. ( Busson, M, 1986) |
| "(1) For symptoms of rheumatoid arthritis (pain, joint stiffness), the reference treatment is a nonsteroidal antiinflammatory drug (NSAID) such as diclofenac or ibuprofen." | 3.72 | Rofecoxib in rheumatoid arthritis: new indication. No better that other NSAIDS. ( , 2003) |
| "A total of 3639 patients with rheumatoid arthritis (RA), osteoarthritis, and fibromyalgia starting therapy of celecoxib, rofecoxib, naproxen, or ibuprofen were surveyed at 6-month intervals for up to 2." | 3.72 | Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice. ( Burke, TA; Michaud, K; Wolfe, F; Zhao, SZ, 2004) |
| "We discuss the case of a 56-year-old white man with a history of rheumatoid arthritis and hypertension who became confused, nauseated, and began to vomit within 2 hours of the ingestion of ibuprofen." | 3.69 | Ibuprofen-induced aseptic meningitis in rheumatoid arthritis. ( Horn, AC; Jarrett, SW, 1997) |
| "We have studied the pharmacokinetics of methotrexate in patients with rheumatoid arthritis concurrently treated with choline magnesium trisalicylate, ibuprofen, naproxen, or a non-NSAID analgesic (control treatment)." | 3.68 | The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis. ( Bradley, JD; Brater, DC; Hall, SD; Jones, DR; Krohn, K; Tracy, TS, 1992) |
| "Low dose methotrexate (MTX) is widely used in the treatment of rheumatoid arthritis." | 3.68 | Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis. ( Coates, J; Friedman, H; Jamali, F; Russell, AS; Skeith, KJ, 1990) |
| "After administration of a single dose and at steady state, ibuprofen concentrations were measured simultaneously in plasma and synovial fluid obtained from eight patients with rheumatoid arthritis." | 3.67 | Ibuprofen kinetics in plasma and synovial fluid of arthritic patients. ( Albert, KS; Gall, EP; Gallo, JM; Gillespie, WR; Perrier, D, 1986) |
| "Studies with benoxaprofen in rheumatoid arthritis and osteoarthritis, conducted in more than 2000 patients, continue to demonstrate its safety and effectiveness." | 3.66 | An update on long-term efficacy and safety with benoxaprofen. ( Mikulaschek, WM, 1982) |
| "Ibuprofen (Brufen) is a non-steroidal anti-inflammatory drug well-established in the symptomatic treatment of rheumatoid arthritis." | 3.66 | Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis. ( Bremova, A; Kankova, D; Kralova, M; Pavelka, K; Susta, A; Vojtisek, O, 1978) |
| " Phenylbutazone (Butazolidin) is probably the drug of choice for acute gout and is also effective in ankylosing spondylitis, Reiter's syndrome, and psoriatic arthritis." | 3.65 | Rheumatic diseases. 2. Therapeutic considerations. ( Biundo, JJ; Gum, OB; Weiss, TE, 1976) |
| "Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis." | 3.65 | Evaluation of ibuprofen (Motrin). A new antirheumatic agent. ( Lewis, JR, 1975) |
| "Ibuprofen generally was found to be toxic, mutagenic, teratogenic and genotoxic agent in various organisms." | 3.01 | Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives. ( Çalışıcı, D; Goktas, B; Yılmaz, S, 2023) |
| " The risk score was designed to predict the 1-year occurrence of major toxicity among NSAID users, including major adverse cardiovascular events, acute kidney injury, significant gastrointestinal events, and mortality." | 2.90 | Derivation and Validation of a Major Toxicity Risk Score Among Nonsteroidal Antiinflammatory Drug Users Based on Data From a Randomized Controlled Trial. ( Husni, ME; Nissen, S; Paynter, N; Shao, M; Solomon, DH; Wolski, K, 2019) |
| " The outcome was major nonsteroidal anti-inflammatory drug toxicity, including time to first occurrence of major adverse cardiovascular events, important gastrointestinal events, renal events, and all-cause mortality." | 2.84 | The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen, or Naproxen: A Secondary Analysis of the PRECISION Trial. ( Borer, JS; Brennan, DM; Husni, ME; Libby, PA; Lincoff, AM; Lϋscher, TF; Menon, V; Nissen, SE; Solomon, DH; Wisniewski, LM; Yeomans, ND, 2017) |
| " Adverse events (AEs) were collected beginning at the first dose and continued through completion (54 weeks)." | 2.80 | One-year open-label safety evaluation of the fixed combination of ibuprofen and famotidine with a prospective analysis of dyspepsia. ( Ball, J; Bello, AE; Grahn, AY; Holt, RJ; Kent, JD, 2015) |
| "Conventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of cyclooxygenase (COX)-1." | 2.69 | Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study. ( Agrawal, NM; Burr, AM; Eisen, G; Faich, G; Geis, GS; Goldstein, JL; Kent, JD; Lefkowith, JB; Makuch, R; Pincus, T; Silverstein, FE; Simon, LS; Stenson, WF; Verburg, KM; Whelton, A; Zhao, WW, 2000) |
| "The subsequent development of mechanical hyperalgesia to pinprick stimuli was then measured at various time points using a 74." | 2.68 | Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. ( Cruwys, SC; Kidd, BL; Morris, VH, 1997) |
| " Indeed, no changes in serum pepsinogen I and II were noted in 80% of the patients in the higher dosage group and in more than 90% of the lower dosage group." | 2.67 | [Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen]. ( Klein, G; Kullich, W; Wallner, H, 1994) |
| "Naproxen-treated patients experienced significantly (p < 0." | 2.67 | Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. ( DeLapp, RE; Eversmeyer, W; Jensen, CP; Poland, M, 1993) |
| " The employment of a special diet favourably influenced the course of the disease and enabled the dosage of antirheumatic drugs to be reduced, thereby reducing the frequency of side-effects of the drugs." | 2.67 | On the medicinal efficacy of dietetic therapy in patients with rheumatoid arthritis. ( Denissov, LN; Samsonov, MA; Sharafetdinov, Kh, 1992) |
| "Ibuprofen (ibu) is a racemic 2-arylpropionic acid non-steroidal anti-inflammatory drug whose activity is due mainly to the S-enantiomer." | 2.67 | S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis. ( Bach, GL; Beck, WS; Brune, K; Geisslinger, G; Loew, D; Stock, KP, 1991) |
| " Long term administration confirmed the safety of indoprofen and the overall incidence of side effects was similar to that associated with ibuprofen therapy." | 2.65 | Three trials of indoprofen. ( Huskisson, EC; Scott, J; Woolf, DL, 1981) |
| "Ibuprofen was significantly better than placebo for relief of morning stiffness and for reducing the amount of supplementary analgesics." | 2.64 | Butacote and ibuprofen: a comparative assessment in rheumatic diseases in general practice. ( Regalado, RG, 1977) |
| "Ibuprofen was selected from this large group." | 2.38 | The propionic acids: a personal perspective. ( Adams, SS, 1992) |
| "Treatment of rheumatoid arthritis is often frustrating for patient and physician alike because of its chronic nature and our lack of knowledge about precise cause." | 2.35 | Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents. ( Kaye, RL; Pemberton, RE, 1976) |
| "Ibuprofen (30 mg/kg) was given twice daily to CIA rats for two weeks starting from Day 18 following the first immunization." | 1.72 | Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathways. ( Chou, CH; Kung, FL; Lin, CJ; Wang, TH; Wu, KC; Yang, CR; Zhang, NY, 2022) |
| "Carbon monoxide (CO) is a gas endogenously produced in humans, reported to exhibit anti-inflammatory and cytoprotective effects at low concentration." | 1.51 | Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. ( Angeli, A; Bartolucci, G; Berrino, E; Bozdag, M; Carta, F; di Cesare Mannelli, L; Ghelardini, C; Menicatti, M; Micheli, L; Milazzo, L; Nocentini, A; Supuran, CT; Vullo, D, 2019) |
| "Hydroxychloroquine (HCQ) is a slow acting DMARD used in the early stage of RA." | 1.42 | Design, Synthesis and In Vitro Release Studies of Co-Drugs for Rheumatoid Arthritis. ( Dhaneshwar, S; Kashmira, P; Poorvashree, J; Shakuntala, C, 2015) |
| " Given the low rates of events, at low or intermittent dosage without concurrent treatment, these 3 analgesics cannot be distinguished from each other or from background rates of serious GI toxicity." | 1.32 | Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis. ( Bruce, B; Fries, JF, 2003) |
| " Since at the same time the tolerability of ibuprofen was also found to be good--4% side effects--it can be recommended also for long-term use in this indication." | 1.28 | [Ibuprofen--successful in activated arthrosis. Results of a administration study]. ( Hilken, K; Lewandowski, C; Rollinger, Y; Seifert, F; Vögtle-Junkert, U, 1992) |
| "S(+)-ibuprofen proved to be an effective analgesic antirheumatic drug in the dose range 1 to 1." | 1.28 | Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis. ( Bach, GL; Brune, K; Geisslinger, G; Loew, D; Schuster, O; Stock, KP, 1990) |
| "Ibuprofen (IBU) is a non-steroidal anti-inflammatory drug exhibiting optical isomerism." | 1.28 | Pharmacological differences between R(-)- and S(+)-ibuprofen. ( Bach, GL; Brune, K; Geisslinger, G; Loew, D; Stock, KP, 1989) |
| " In addition, ibuprofen can be combined with acetaminophen without altering the pharmacokinetic profile." | 1.27 | Pharmacokinetics of ibuprofen. ( Albert, KS; Gernaat, CM, 1984) |
| "Ibuprofen was less strongly bound to rheumatoid plasma than to normal plasma but this difference can be accounted for by the difference in albumin concentration between the two plasmas." | 1.27 | The binding of ibuprofen to plasma proteins. ( Aarons, L; Grennan, DM; Siddiqui, M, 1983) |
| " Pharmacokinetic variables probably account for only a small part of the inter-individual variation in response of rheumatoid patients treated with increasing dosages of the non-steroidal, anti-inflammatory drug ibuprofen." | 1.27 | Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings. ( Aarons, L; Grennan, DM; Higham, C; Richards, M; Siddiqui, M; Thompson, R, 1983) |
| " An overestimation of rare side-effects of drugs should not block the application of certain medicaments, however, they should be given only in such a high dosage as it is necessary." | 1.26 | [Hematotoxic lesions caused by non-steroidal antirheumatic agents]. ( Hüge, W; Stobbe, H, 1980) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 127 (58.80) | 18.7374 |
| 1990's | 31 (14.35) | 18.2507 |
| 2000's | 27 (12.50) | 29.6817 |
| 2010's | 23 (10.65) | 24.3611 |
| 2020's | 8 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Bansal, Y | 1 |
| Kaur, M | 1 |
| Silakari, O | 1 |
| Bua, S | 2 |
| Di Cesare Mannelli, L | 4 |
| Vullo, D | 2 |
| Ghelardini, C | 4 |
| Bartolucci, G | 3 |
| Scozzafava, A | 1 |
| Supuran, CT | 3 |
| Carta, F | 3 |
| Berrino, E | 1 |
| Milazzo, L | 1 |
| Micheli, L | 3 |
| Angeli, A | 1 |
| Bozdag, M | 1 |
| Nocentini, A | 2 |
| Menicatti, M | 2 |
| Lucarini, L | 1 |
| Selleri, S | 1 |
| Masini, E | 1 |
| Gratteri, P | 1 |
| Yu, WY | 1 |
| Shen, SW | 1 |
| Yang, ZH | 1 |
| Khan, D | 1 |
| Qindeel, M | 1 |
| Ahmed, N | 1 |
| Asad, MI | 1 |
| Shah, KU | 1 |
| Obeid, S | 1 |
| Libby, P | 4 |
| Husni, E | 1 |
| Wang, Q | 3 |
| Wisniewski, LM | 5 |
| Davey, DA | 2 |
| Wolski, KE | 3 |
| Xia, F | 1 |
| Bao, W | 3 |
| Walker, C | 2 |
| Ruschitzka, F | 2 |
| Nissen, SE | 5 |
| Lüscher, TF | 4 |
| Zhang, NY | 1 |
| Wang, TH | 1 |
| Chou, CH | 1 |
| Wu, KC | 1 |
| Yang, CR | 1 |
| Kung, FL | 1 |
| Lin, CJ | 1 |
| Çalışıcı, D | 1 |
| Yılmaz, S | 1 |
| Goktas, B | 1 |
| Dhokia, M | 1 |
| Elander, J | 1 |
| Clements, K | 1 |
| Gilbert, P | 1 |
| Choudhary, N | 1 |
| Gupta, R | 1 |
| Bhatt, LK | 1 |
| Upadhyay, A | 1 |
| Amanullah, A | 1 |
| Joshi, V | 1 |
| Dhiman, R | 1 |
| Prajapati, VK | 1 |
| Poluri, KM | 1 |
| Mishra, A | 1 |
| Raschle, J | 1 |
| Solomon, DH | 5 |
| Husni, ME | 5 |
| Libby, PA | 1 |
| Yeomans, ND | 4 |
| Lincoff, AM | 4 |
| Lϋscher, TF | 1 |
| Menon, V | 3 |
| Brennan, DM | 1 |
| Borer, JS | 4 |
| Eccleston, C | 1 |
| Cooper, TE | 1 |
| Fisher, E | 1 |
| Anderson, B | 1 |
| Wilkinson, NM | 1 |
| Palmsten, K | 1 |
| Hulugalle, A | 1 |
| Bandoli, G | 1 |
| Kuo, GM | 1 |
| Ansari, S | 1 |
| Xu, R | 1 |
| Chambers, CD | 1 |
| Krum, H | 1 |
| Flammer, AJ | 1 |
| Graham, DY | 3 |
| Fayyad, R | 1 |
| Beckerman, B | 1 |
| Iorga, D | 1 |
| Berger, MF | 1 |
| Chen, YR | 1 |
| Hsieh, FI | 1 |
| Chang, CC | 1 |
| Chi, NF | 1 |
| Wu, HC | 1 |
| Chiou, HY | 1 |
| Stevens, T | 1 |
| Vargo, J | 1 |
| Lucarini, E | 1 |
| Parisio, C | 1 |
| Trallori, E | 1 |
| Cinci, L | 1 |
| Shao, M | 1 |
| Wolski, K | 1 |
| Nissen, S | 1 |
| Paynter, N | 1 |
| Kuan, R | 1 |
| Holt, RJ | 4 |
| Johnson, KE | 1 |
| Kent, JD | 5 |
| Peura, DA | 1 |
| Malone, D | 1 |
| Bello, AE | 3 |
| Grahn, AY | 2 |
| Ball, J | 2 |
| Kashmira, P | 1 |
| Dhaneshwar, S | 1 |
| Shakuntala, C | 1 |
| Poorvashree, J | 1 |
| Nagai, N | 1 |
| Tanino, T | 1 |
| Ito, Y | 1 |
| Cong, XD | 1 |
| Ding, MJ | 1 |
| Dai, DZ | 1 |
| Wu, Y | 1 |
| Zhang, Y | 1 |
| Dai, Y | 1 |
| Halford, GM | 1 |
| Lordkipanidzé, M | 1 |
| Watson, SP | 1 |
| Schiff, M | 1 |
| Peura, D | 1 |
| Hunt, RH | 1 |
| Harper, S | 1 |
| Callegari, P | 1 |
| Yu, C | 1 |
| Quan, H | 1 |
| Evans, J | 1 |
| James, C | 1 |
| Bowen, B | 1 |
| Rashid, F | 1 |
| Rainsford, KD | 1 |
| Balabanova, RM | 1 |
| Fries, JF | 2 |
| Bruce, B | 2 |
| Shi, W | 1 |
| Wang, YM | 1 |
| Cheng, NN | 1 |
| Chen, BY | 1 |
| Li, D | 1 |
| Wolfe, F | 1 |
| Michaud, K | 1 |
| Burke, TA | 1 |
| Zhao, SZ | 1 |
| Paulus, HE | 2 |
| Di Primeo, D | 2 |
| Sharp, JT | 2 |
| Genant, HK | 2 |
| Weissman, BN | 2 |
| Weisman, MH | 1 |
| Sanda, M | 3 |
| Idänpään-Heikkilä, JE | 1 |
| Idänpään-Heikkilä, JJ | 1 |
| Klaukka, T | 1 |
| Kivitz, AJ | 1 |
| Nayiager, S | 1 |
| Schimansky, T | 1 |
| Gimona, A | 1 |
| Thurston, HJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen[NCT00346216] | Phase 4 | 24,081 participants (Actual) | Interventional | 2006-10-04 | Completed | ||
| Open-Label Safety Study of HZT-501 in Patients Who Require Long-Term Daily Non-Steroidal Anti-Inflammatory Drug Treatment[NCT00984815] | Phase 3 | 86 participants (Actual) | Interventional | 2009-09-30 | Completed | ||
| A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 in Subjects Requiring NSAID Treatment[NCT00450658] | Phase 3 | 627 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| A Randomized, Double-Blind, Phase 3 Study of the Efficacy and Safety of HZT-501 in Subjects Requiring NSAID Treatment[NCT00450216] | Phase 3 | 906 participants (Actual) | Interventional | 2007-03-31 | Completed | ||
| An Open-label, Randomized, 3-way Crossover Study to Evaluate the Pharmacokinetics of Investigational Product Ibuprofen Modified-Release Tablets 800 mg Compared to Ibuprofen Tablets 800 mg in Healthy Volunteers[NCT05329454] | Phase 1 | 30 participants (Actual) | Interventional | 2020-12-24 | Completed | ||
| Type of Magnetic Field and the Effects of Rheumatoid Arthritis Treatment[NCT04426513] | 62 participants (Actual) | Interventional | 2020-05-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"VAS question How much pain do you have was graded on a scale from 0 to 100 with 0 indicating No pain and 100 indicating Worst possible pain." (NCT00346216)
Timeframe: ITT and MITT Population - Baseline to 42 months
| Intervention | Number of participants (Mean) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (ITT) N= 8014, 8001, 7928 | Change-Baseline to Mon1 (ITT) N=7382, 7379, 7325 | Change-Baseline to Mon2 (ITT) N=7180, 7090, 7149 | Change-Baseline to Mon4 (ITT) N=6777, 6696, 6740 | Change-Baseline to Mon8 (ITT) N=6230, 6137, 6159 | Change-Baseline to Mon12 (ITT) N=5792, 5696, 5846 | Change-Baseline to Mon18 (ITT) N=5310, 5181. 5246 | Change-Baseline to Mon24 (ITT) N=4818, 4776, 4785 | Change-Baseline to Mon30 (ITT) N=4140, 4069, 4086 | Change-Baseline to Mon36 (ITT) N=3692, 3627, 3635 | Change-Baseline to Mon42 (ITT) N=3469, 3406, 3439 | Baseline (MITT) N=7974, 7954, 7894 | Change-Baseline to Mon1 MITT N=7372, 7367, 7321 | Change-Baseline to Mon2 MITT N=7170, 7078, 7142 | Change-Baseline to Mon4 MITT N=6772, 6686, 6732 | Change-Baseline to Mon8 MITT N=6224, 6128, 6155 | Change-Baseline to Mon12 MITT N=5787, 5689, 5844 | Change-Baseline to Mon18 MITT N=5305, 5175, 5242 | Change-Baseline to Mon24 MITT N=4815, 4769, 4782 | Change-Baseline to Mon30 MITT N=4139, 4067, 4085 | Change-Baseline to Mon36 MITT N=3691, 3623, 3635 | Change-Baseline to Mon42 MITT N=3468, 3404, 3438 | |
| Celecoxib | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.3 | -10.5 | -10.1 | -11.4 | 54.0 | -8.2 | -10.5 | -11.4 | -11.7 | -11.0 | -11.3 | -11.4 | -10.5 | -10.2 | -11.4 |
| Ibuprofen | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 | 54.1 | -9.0 | -10.6 | -11.7 | -12.1 | -11.6 | -11.3 | -11.5 | -11.2 | -10.7 | -11.1 |
| Naproxen | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.4 | -11.3 | -11.6 | -12.1 | 54.1 | -9.9 | -11.1 | -12.3 | -12.1 | -11.9 | -11.7 | -11.3 | -11.3 | -11.6 | -12.1 |
MACE defined as the composite of CV death (including hemorrhagic death), non-fatal MI, non-fatal stroke, hospitalization for UA, revascularization or hospitalization for TIA (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 4.2 | 3.1 |
| Ibuprofen | 4.8 | 3.6 |
| Naproxen | 4.3 | 3.2 |
APTC events are defined as a composite of any of the following events: Death due to CV causes (including cardiac, cerebrovascular, venous thromboembolic, haemorrhagic, other vascular, or unknown cause); Non-fatal MI; Non-fatal stroke (including intracranial hemorrhages, stroke of ischemic or unknown etiology). (NCT00346216)
Timeframe: Intent to Treat (ITT) Population - 30 months; Modified ITT (MITT) Population - 42 months
| Intervention | Percentage of Partcipants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 2.3 | 1.7 |
| Ibuprofen | 2.7 | 1.9 |
| Naproxen | 2.5 | 1.8 |
CSGIE include: Gastroduodenal (GD) hemorrhage, Gastric outlet obstruction, Gastroduodenal, small bowel or large bowel perforation, Large bowel hemorrhage, Small bowel hemorrhage, Acute GI hemorrhage of unknown origin, including presumed small bowel hemorrhage, Symptomatic gastric or duodenal ulcer (NCT00346216)
Timeframe: ITT Population - 30 months; MITT Population - 42 months
| Intervention | Percentage of Participants (Number) | |
|---|---|---|
| ITT (N = 8072, 8040, 7969) | MITT (N = 8030, 7990, 7933) | |
| Celecoxib | 0.7 | 0.3 |
| Ibuprofen | 0.9 | 0.7 |
| Naproxen | 0.7 | 0.7 |
The non-pain symptom scale of the SODA questionnaire ranges from 7 - 35. Change from baseline compares the score at Week 54 to the baseline score for each participant that completed the non-pain symptom questions of the SODA questionnaire at baseline and Week 54. Higher scores indicate greater symptom severity and therefore a negative mean change from baseline is indicative of an improvement in symptoms. (NCT00984815)
Timeframe: Baseline and 54 Weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| HZT-501 | -1.44 |
The pain intensity scale of the SODA questionnaire ranges from 2 - 47. Change from baseline compares the score at Week 54 to the baseline score for each participant who completed the pain intensity questions of the SODA questionnaire at baseline and Week 54. Higher scores indicate greater symptom severity and therefore a negative mean change from baseline is indicative of an improvement in symptoms. (NCT00984815)
Timeframe: Baseline and 54 Weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| HZT-501 | -3.22 |
The satisfaction with dyspepsia-related health scale of the SODA questionnaire ranges from 2 - 23. Change from baseline compares the score at Week 54 to the baseline score for each participant who completed the Satisfaction questions of the SODA questionnaire at baseline and Week 54. A positive change from baseline in the SODA satisfaction scale represents a participant's overall improved satisfaction with their dyspepsia-related health. (NCT00984815)
Timeframe: Baseline and 54 Weeks
| Intervention | Scores on a scale (Mean) |
|---|---|
| HZT-501 | 2.69 |
(NCT00984815)
Timeframe: 54 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 76 |
The secondary efficacy endpoint was the number of subjects with duodenal ulcer at any time throughout the 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A subject is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450658)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 3 |
| Ibuprofen | 9 |
The secondary efficacy endpoint was the number of subjects with gastric ulcer at any time throughout 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A subject is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450658)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 37 |
| Ibuprofen | 34 |
The primary efficacy endpoint was the number of subjects with upper gastrointestinal (i.e., gastric and/or duodenal) ulcer at any time throughout 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A subject is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450658)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 40 |
| Ibuprofen | 38 |
The secondary efficacy endpoint was the number of subjects developing a NSAID-associated serious GI complication at any time throughout 6 months of treatment. A NSAID-associated serious GI complication was defined as a perforation of ulcers, gastric outlet obstruction due to ulcers, and/or GI bleeding. (NCT00450658)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 0 |
| Ibuprofen | 0 |
The secondary efficacy endpoint was the number of participants with duodenal ulcer at any time throughout 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A participant is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450216)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 8 |
| Ibuprofen | 14 |
The primary efficacy endpoint was the number of participants with gastric ulcer at any time throughout 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A participant is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450216)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 55 |
| Ibuprofen | 52 |
The secondary efficacy endpoint was the number of participants with UGI (i.e., gastric and/or duodenal) ulcer at any time throughout 24 weeks of treatment. An ulcer was defined as a mucosal break of at least 3 mm in diameter with unequivocal depth. A participant is considered to have completed the study if all scheduled assessments up through the Week 24 visit have been performed. (NCT00450216)
Timeframe: 24 weeks
| Intervention | participants (Number) |
|---|---|
| HZT-501 | 63 |
| Ibuprofen | 61 |
The secondary efficacy endpoint was the number of participants developing a NSAID-associated serious gastrointestinal complication at any time throughout 24 weeks of treatment. A NSAID-associated serious gastrointestinal complication was defined as a perforation of ulcers, gastric outlet obstruction due to ulcers, and/or gastrointestinal bleeding. (NCT00450216)
Timeframe: 24 weeks
| Intervention | particpants (Number) |
|---|---|
| HZT-501 | 3 |
| Ibuprofen | 0 |
19 reviews available for ibuprofen and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Toxic, Genotoxic and Teratogenic Effects of Ibuprofen and its Derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; DNA Damage; Humans; Ibuprof | 2023 |
Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Juvenile; Arthritis, Rheumatoid; Asp | 2017 |
HZT-501 (DUEXIS(®); ibuprofen 800 mg/famotidine 26.6 mg) gastrointestinal protection in the treatment of the signs and symptoms of rheumatoid arthritis and osteoarthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Drug Combinations | 2012 |
Discovery, mechanisms of action and safety of ibuprofen.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; | 2003 |
[Current concepts of pharmacotherapy in rheumatoid arthritis].
Topics: Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents | 2003 |
[Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; China; Diclofenac; Humans | 2003 |
[Treatment for inflammation related pain--COX-2 inhibitors knocking on the door].
Topics: Acetaminophen; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Dysmenorrhea; Female; Humans; Ibupr | 2004 |
Ibuprofen and Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Ibuprofen | 2004 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; | 1984 |
Mechanism of action of nonsteroidal anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis, Rheumatoid; Carba | 1984 |
Diclofenac sodium: a review of its pharmacological properties and therapeutic use in rheumatic diseases and pain of varying origin.
Topics: Adult; Animals; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Diclofenac; Drug Interact | 1980 |
Nonsteroidal antiinflammatory drugs (second of two parts).
Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Fenoprofen; Humans; Ibuprofen; Mefenamic | 1980 |
Celecoxib clinical profile.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec | 2000 |
Antiinflammatory drugs.
Topics: Adult; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Benzylidene Compounds; Chi | 1977 |
Treatment of rheumatoid arthritis: a review including newer and experimental anti-inflammatory agents.
Topics: Activities of Daily Living; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antimalarials; Arthri | 1976 |
Rheumatoid arthritis: an overview.
Topics: Adult; Arthritis; Arthritis, Reactive; Arthritis, Rheumatoid; Aspirin; Diagnosis, Differential; Fema | 1976 |
The propionic acids: a personal perspective.
Topics: Analgesia; Animals; Arthritis, Rheumatoid; Aspirin; Drug Therapy; Flurbiprofen; Humans; Ibuprofen; P | 1992 |
Rheumatoid pleuritis.
Topics: Arthritis, Rheumatoid; Diagnosis, Differential; Female; Humans; Ibuprofen; Middle Aged; Pleural Effu | 1990 |
Update on ibuprofen: review article.
Topics: Analgesia; Arthritis; Arthritis, Rheumatoid; Clinical Trials as Topic; Connective Tissue Diseases; D | 1986 |
104 trials available for ibuprofen and Arthritis, Rheumatoid
| Article | Year |
|---|---|
A clinical study of Suogudan granule in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Antistreptolysin; Arthritis, Rheumatoid; Blood Sedimentation; Dru | 2005 |
Cardiorenal risk of celecoxib compared with naproxen or ibuprofen in arthritis patients: insights from the PRECISION trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; | 2022 |
A randomized-controlled pilot trial of an online compassionate mind training intervention to help people with chronic pain avoid analgesic misuse.
Topics: Acetaminophen; Adult; Analgesics; Analgesics, Opioid; Arthritis, Rheumatoid; Aspirin; Back Pain; Chr | 2020 |
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Celecoxib; Double-Blind Method; Drug Therapy, | 2017 |
The Risk of Major NSAID Toxicity with Celecoxib, Ibuprofen, or Naproxen: A Secondary Analysis of the PRECISION Trial.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase 2 Inhibito | 2017 |
Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement)
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Pressure; Celecoxib; Coronary | 2017 |
Differences in Safety of Nonsteroidal Antiinflammatory Drugs in Patients With Osteoarthritis and Patients With Rheumatoid Arthritis: A Randomized Clinical Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec | 2018 |
Randomised clinical trial: gastrointestinal events in arthritis patients treated with celecoxib, ibuprofen or naproxen in the PRECISION trial.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Aspi | 2018 |
Derivation and Validation of a Major Toxicity Risk Score Among Nonsteroidal Antiinflammatory Drug Users Based on Data From a Randomized Controlled Trial.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cardiovascular Diseases; Celec | 2019 |
One-year open-label safety evaluation of the fixed combination of ibuprofen and famotidine with a prospective analysis of dyspepsia.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Combinations; Drug | 2015 |
One-year safety of ibuprofen/famotidine fixed combination versus ibuprofen alone: pooled analyses of two 24-week randomized, double-blind trials and a follow-on extension.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Combinations; Drug | 2015 |
Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ibuprofen in older persons.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Age | 2015 |
Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ibuprofen in older persons.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Age | 2015 |
Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ibuprofen in older persons.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Age | 2015 |
Gastroprotective efficacy and safety of single-tablet ibuprofen/famotidine vs ibuprofen in older persons.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Age | 2015 |
Complementary studies of the gastrointestinal safety of the cyclo-oxygenase-2-selective inhibitor etoricoxib.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cyclooxygenase 2; Cyclooxygenase | 2003 |
Patient retention and hand-wrist radiograph progression of rheumatoid arthritis during a 3-year prospective study that prohibited disease modifying antirheumatic drugs.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; D | 2004 |
Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygen | 2004 |
Valdecoxib is associated with improved dyspepsia-related health compared with nonspecific NSAIDs in patients with osteoarthritis or rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Diclofena | 2005 |
Cardiorenal effects of celecoxib as compared with the nonsteroidal anti-inflammatory drugs diclofenac and ibuprofen.
Topics: Acid-Base Equilibrium; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, | 2006 |
Anti-inflammatory (ibuprofen) drug therapy in rheumatoid arthritis--rate of response and lack of time dependency of plasma pharmacokinetics.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Humans; Ibuprofen; Kinetics; Time Factors | 1983 |
[Lonazolac - a new non-steroidal antirheumatic agent. Report of a double-blind crossover clinical study].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1983 |
A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 1983 |
[Comparison of the effects of diflunisal, ibuprofen and placebo in chronic polyarthritis].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Humans; Ibup | 1983 |
Update on ibuprofen for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Tolerance; | 1984 |
A double-blind comparison of tenoxicam (Tilcotil, Mobiflex) at two doses against ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1984 |
Comparative study of piroxicam and ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Evaluation; Female | 1983 |
Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
Topics: Adult; Aged; Analgesics; Anti-Inflammatory Agents; Apazone; Arthritis, Rheumatoid; Aspirin; Carbazol | 1984 |
Anti-rheumatic efficacy of naproxen.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Digestive System; Female; | 1982 |
Tolfenamic acid and ibuprofen in rheumatoid arthritis: a double-blind cross over study.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Humans; Ibuprof | 1981 |
Diclofenac and ibuprofen in rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Ib | 1980 |
Long-term safety of benoxaprofen.
Topics: Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxazoles; Blood Urea Nitrogen; C | 1980 |
Long-term efficacy and safety of benoxaprofen: comparison with aspirin and ibuprofen in patients with active rheumatoid arthritis.
Topics: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzoxa | 1980 |
Diclofenac sodium (Voltaren) and ibuprofen in rheumatoid arthritis. A randomized double-blind study.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Femal | 1980 |
Arthritis: anti-inflammatory drugs in practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Apazone; Arthritis, Rheumatoid; As | 1981 |
Ibuprofen and diflunisal in rheumatoid arthritis: a double-blind comparative trial.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Female; Humans; Ib | 1981 |
Double-blind cross-over study of indoprofen versus ibuprofen and placebo in rheumatoid arthritis patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Bli | 1981 |
Three trials of indoprofen.
Topics: Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; C | 1981 |
Choline magnesium trisalicylate versus ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Choline; Female; Humans; Ibuprofen; Male; Middle Aged; Salicylat | 1980 |
Naproxen suppositories in combination with oral naproxen, indomethacin and ibuprofen in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Humans; | 1980 |
Quantitative assessment of joint pain following treatment of rheumatoid arthritis with ibuprofen cream.
Topics: Administration, Topical; Arthritis, Rheumatoid; Double-Blind Method; Humans; Ibuprofen; Middle Aged; | 1994 |
The stereoselective disposition of the enantiomers of ibuprofen in blood, blister and synovial fluid.
Topics: Absorption; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Extracellular Space; Gas Ch | 1994 |
Investigation into the duration of action of sustained-release ibuprofen in osteoarthritis and rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Ibupr | 1994 |
Gas chromatographic-mass spectrometric determination of ibuprofen enantiomers in human plasma using R(-)-2,2,2-trifluoro-1-(9-anthryl)ethanol as derivatizing reagent.
Topics: Anthracenes; Arthritis, Rheumatoid; Gas Chromatography-Mass Spectrometry; Humans; Ibuprofen; Indicat | 1994 |
[Determination of serum pepsinogen I and II for assessment of gastroduodenal tolerance of S(+) ibuprofen].
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; | 1994 |
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Ibuprofen; Male; Stereoisomerism | 1993 |
Safety experience with nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Diclofenac; | 1993 |
Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in the elderly.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; | 1993 |
Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Diclofenac; | 1993 |
Double blind evaluation of the long-term effects of etodolac versus ibuprofen in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Progression; Double-B | 1997 |
Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Capsaicin; Dose-Response Rela | 1997 |
[Will administration of omega-3 unsaturated fatty acids reduce the use of nonsteroidal antirheumatic agents in children with chronic juvenile arthritis?].
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Child; Child, Preschool; | 1998 |
[Can local therapy of joint syndrome with Dolgit cream be used as an alternative to systemic nonsteroid antiinflammatory drugs in rheumatic diseases?].
Topics: Administration, Topical; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Anti-Inflammatory Agents | 1998 |
A decision analysis model in the evaluation of NSAIDs in a managed care setting: a case study.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Butanones; Decision Tre | 1994 |
[Specific cyclo-oxygenase inhibitors. 2. Gastric toxicity?].
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase Inhi | 2000 |
Progression of radiographic joint erosion during low dose corticosteroid treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Arthrography; Disease Progression; Dose-Response Rel | 2000 |
Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.
Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; | 2000 |
Evaluation of analgesic action and efficacy of antirheumatic drugs. Study of 10 drugs in 684 patients with rheumatoid arthritis.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Tri | 1976 |
[Sulindac: Clinical test of a new antiinflammatory agent in rheumatoid arthritis (author's transl)].
Topics: Adult; Aged; Alopecia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Benzylidene Compoun | 1976 |
A controlled clinical study comparing sulindac with ibuprofen and aspirin in the treatment of musculo-skeletal diseases.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; | 1979 |
A long-term double-blind clinical trial of ibuprofen and indomethacin in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Female; Humans; Ibuprofen; Indomethacin; Male; Middle Ag | 1975 |
Comparison of benorylate and ibuprofen in the treatment of established rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Hand; Humans; Ibuprofen; Pain; Propionates; Salicyl | 1975 |
Treatment of rheumatoid arthritis with flurbiprofen or ibuprofen.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Flurbiprofen; Humans; Ibup | 1977 |
Double-blind, multi-centre parallel trial of ketoprofen and ibuprofen in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Benzophenones; Clinical Trials as Topic; Drug Evaluation; Female | 1977 |
Mefenamic acid compared with ibuprofen in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Female; Humans; I | 1977 |
Butacote and ibuprofen: a comparative assessment in rheumatic diseases in general practice.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Family Practice; Female; Humans; Ibuprofen; Male; O | 1977 |
Drug trial in rheumatoid arthritis: a new design.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Eva | 1978 |
High doses of ibuprofen in rheumatoid arthritis: a comparison with aspirin.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Female; Humans; Ibuprofen; Male; Middle Ag | 1977 |
[Results of a double-blind controlled study of the comparative effects of ketoprofen and ibuprofen in orthopedic patients].
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; | 1978 |
A long-term double-blind comparative study on proquazone (Biarison) and ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1978 |
A comparative study of indomethacin and ibuprofen.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; | 1979 |
A review of upper-gastrointestinal effects of the newer nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Clinical Trials as | 1979 |
Tolfenamic acid in the treatment of rheumatoid arthritis.
Topics: Administration, Oral; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; A | 1979 |
A comparison of sulindac with ibuprofen in the management of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Humans; Ibuprofen | 1979 |
A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Ket | 1979 |
A crossover clinical trial of piroxicam, indomethacin and ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topi | 1979 |
The aspirin-ibuprofen interaction in rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Double-Blind Method; Drug Com | 1979 |
A controlled trial of tiaprofenic acid versus ibuprofen in rheumatoid arthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind | 1979 |
Analysis of the Brazilian literature on diclofenac sodium (Voltarol).
Topics: Arthritis, Rheumatoid; Brazil; Clinical Trials as Topic; Diclofenac; Drug Tolerance; Female; Humans; | 1979 |
Diclofenac sodium (Voltarol): a double-blind comparative study with ibuprofen in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug | 1979 |
[Treatment of chronic polyarthritis with Sulindac].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzylidene Compounds; Clinical Trials | 1977 |
[Double-blind cross-over clinical study of the effectiveness and tolerability of fenbufen versus ibuprofen in the therapy of rheumatoid arthritis].
Topics: Adult; Aged; Arthritis, Rheumatoid; Biphenyl Compounds; Double-Blind Method; Drug Evaluation; Female | 1979 |
[Treatment of arthrosis deformans with indomethacin and ibuprofen; a comparative study].
Topics: Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Ibuprofen; Indomethacin; Male | 1975 |
Four new anti-inflammatory drugs: responses and variations.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Fenoprofen; Gastrointesti | 1976 |
Comparison of effectiveness of mefenamic acid and ibuprofen in treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Humans; Ibuprofen; Male; Mefenamic Acid; Ph | 1976 |
Ketoprofen - clinical efficacy.
Topics: Acetaminophen; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Aspirin; Benzophenones; C | 1976 |
Ibuprofen or aspirin in rheumatoid arthritis therapy.
Topics: Aged; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspirin; Central Nervous System; Clinical Trials | 1975 |
On the medicinal efficacy of dietetic therapy in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Combined Modality Therapy; Diclofenac; Female; Humans; Ibuprofen | 1992 |
S-ibuprofen versus ibuprofen-racemate. A randomized double-blind study in patients with rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; | 1991 |
[Assessment of the effect of ibuprofen and other non-steroidal anti-rheumatic drugs in experimental algesimetry].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Ibuprofen; Noc | 1991 |
[Validation of electronic by conventional pain diaries].
Topics: Adult; Arthritis, Rheumatoid; Data Collection; Female; Humans; Ibuprofen; Male; Microcomputers; Midd | 1991 |
A double-blind crossover study to compare lysine acetyl salicylate (Aspergesic) with ibuprofen in the treatment of rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; | 1990 |
[The dynamics of the analgesic effect of non-steroidal antirheumatic drugs. Ibuprofenlysinate versus diclofenac].
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; Ibuprofen; | 1989 |
The effect of etodolac administration on renal function in patients with arthritis.
Topics: Acetates; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Urea | 1986 |
Four popular anti-inflammatories. Which?
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Evaluation; Female | 1988 |
Multicenter double-blind randomized clinical trial of imidazole salicylate versus ibuprofen in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Clinical Trials as Topic; Dou | 1987 |
Effects of suprofen on renal function in patients with rheumatoid arthritis.
Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Dinoprost; Double-Blin | 1987 |
Update on ibuprofen: review article.
Topics: Analgesia; Arthritis; Arthritis, Rheumatoid; Clinical Trials as Topic; Connective Tissue Diseases; D | 1986 |
International experience with diclofenac in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Humans; I | 1986 |
Efficacy and safety of diclofenac sodium in rheumatoid arthritis. Experience in the United States.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Meth | 1986 |
Renal safety of two analgesics used over the counter: ibuprofen and aspirin.
Topics: Adult; Aged; Arthritis, Rheumatoid; Aspirin; Blood Urea Nitrogen; Clinical Trials as Topic; Creatini | 1986 |
A 12-week, double-blind, multicenter study comparing diflunisal twice daily and ibuprofen four times daily in the treatment of rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Diflunisal; Double-Blind Method; Drug | 1986 |
Relief of morning stiffness: a comparative study of naproxen and ibuprofen.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Femal | 1985 |
A double-blind comparative study of piroxicam and ibuprofen in the treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Mal | 1985 |
Ibuprofen in rheumatoid arthritis. Clinical study of analgesic and anti-inflammatory activity.
Topics: Adult; Aged; Alanine Transaminase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Aspirin; Doub | 1968 |
Evaluation of ibuprofen in the treatment of rheumatoid arthritis assessed by sequential analysis.
Topics: Arthritis, Rheumatoid; Double-Blind Method; Hospitalization; Humans; Ibuprofen; Joints; Phenylbutazo | 1973 |
Comparison of anti-rheumatic effects of phenylbutazone and ibuprofen.
Topics: Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Female; Human | 1974 |
95 other studies available for ibuprofen and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Benzimidazole--ibuprofen/mesalamine conjugates: potential candidates for multifactorial diseases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Benzimidazoles; Edema; Ibup | 2015 |
Design and Synthesis of Novel Nonsteroidal Anti-Inflammatory Drugs and Carbonic Anhydrase Inhibitors Hybrids (NSAIDs-CAIs) for the Treatment of Rheumatoid Arthritis.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydr | 2017 |
Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Carbon Monoxide; Carbonic Anhydrase Inhibitors | 2019 |
Bioisosteric Development of Multitarget Nonsteroidal Anti-Inflammatory Drug-Carbonic Anhydrases Inhibitor Hybrids for the Management of Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Carbonic Anhydrase Inhibito | 2020 |
Development of an intelligent, stimuli-responsive transdermal system for efficient delivery of Ibuprofen against rheumatoid arthritis.
Topics: Administration, Cutaneous; Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Ibuprofen; Mice; N | 2021 |
Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathways.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cytokines; Excitatory Amino Acid Transporte | 2022 |
Anti-rheumatic activity of Phenethyl isothiocyanate via inhibition of histone deacetylase-1.
Topics: Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumat | 2020 |
Ibuprofen-based advanced therapeutics: breaking the inflammatory link in cancer, neurodegeneration, and diseases.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Female; Humans; Ibuprofen; Neoplasms | 2021 |
Agreement Between Maternal Report and Medical Records During Pregnancy: Medications for Rheumatoid Arthritis and Asthma.
Topics: Adult; Albuterol; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Asthma; Et | 2018 |
Effect on Risk of Stroke and Acute Myocardial Infarction of Nonselective Nonsteroidal Anti-Inflammatory Drugs in Patients With Rheumatoid Arthritis.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; | 2018 |
Intra-articular mucilages: behavioural and histological evaluations for a new model of articular pain.
Topics: Althaea; Analgesics; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Flax; Freund's Adjuvan | 2019 |
Budget impact modeling for a single-tablet formulation of ibuprofen and famotidine for prevention of upper gastrointestinal ulcers in patients with osteoarthritis and/or rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Drug Combinations | 2013 |
Design, Synthesis and In Vitro Release Studies of Co-Drugs for Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Drug | 2015 |
Pharmacokinetic Studies of Gel System Containing Ibuprofen Solid Nanoparticles.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Disease Models, Animal; Gel | 2016 |
A fixed-dose combination ibuprofen and famotidine (Duexis).
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Drug Combinations; Duodenal Ulcer; F | 2011 |
ER stress, p66shc, and p-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats.
Topics: Activating Transcription Factor 6; Adjuvants, Immunologic; Animals; Anthraquinones; Anti-Inflammator | 2012 |
50th anniversary of the discovery of ibuprofen: an interview with Dr Stewart Adams.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase Inhibitors; Drug Disc | 2012 |
Rofecoxib in rheumatoid arthritis: new indication. No better that other NSAIDS.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Contraindications; Cyclooxygenase In | 2003 |
Rates of serious gastrointestinal events from low dose use of acetylsalicylic acid, acetaminophen, and ibuprofen in patients with osteoarthritis and rheumatoid arthritis.
Topics: Acetaminophen; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dose-R | 2003 |
Longer use of COX-2-specific inhibitors compared to nonspecific nonsteroidal antiinflammatory drugs: a longitudinal study of 3639 patients in community practice.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Community Health Services | 2004 |
The rise and decline of nonsteroidal antiinflammatory drug-associated gastropathy in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Female; Humans; Ibuprofen; | 2004 |
Ibuprofen tops acetaminophen for treating arthritis.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Arthritis, Rheumatoid; Humans; Ibuprofen | 2005 |
Magnetic resonance imaging in the differential diagnosis between polymyalgia rheumatica and elderly onset rheumatoid arthritis.
Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumat | 2006 |
Differential regulation of anti-inflammatory proteins in human rheumatoid synoviocyte MH7A cell by celecoxib and ibuprofen.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Celecoxib; Cell Line; Electrophoresi | 2006 |
[Study results of routine clinical practice. Do rheumatism patients get substandard care?].
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; | 2005 |
Some reflections on ibuprofen.
Topics: Analgesics; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; History, 21st Century; I | 2007 |
Inhibition of neutrophil activation by nonsteroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Cell Aggregation; Humans; Ibuprofen; In Vi | 1984 |
Clinical assessment of the renal toxicity of antirheumatic drugs.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Dinoprostone | 1984 |
Use of ibuprofen in unusual circumstances.
Topics: Arthritis, Rheumatoid; Aspirin; Bartter Syndrome; Cyclooxygenase Inhibitors; Digoxin; Drug Hypersens | 1984 |
Ibuprofen--past, present, and future.
Topics: Animals; Arthritis, Rheumatoid; Blood Vessel Prosthesis; Drug Tolerance; Humans; Ibuprofen; Kinetics | 1984 |
Pharmacokinetics of ibuprofen.
Topics: Acetaminophen; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Aspirin; Biological Availability; Ch | 1984 |
The binding of ibuprofen to plasma proteins.
Topics: Arthritis, Rheumatoid; Binding, Competitive; Humans; Ibuprofen; Protein Binding; Salicylates; Salicy | 1983 |
Dose-response study with ibuprofen in rheumatoid arthritis: clinical and pharmacokinetic findings.
Topics: Adult; Aged; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Half-Life; Humans; Ibuprofen; | 1983 |
Rheumatoid arthritis IV: non-steroidal anti-inflammatory agents use in treatment.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Hu | 1982 |
An update on long-term efficacy and safety with benoxaprofen.
Topics: Alkaline Phosphatase; Anemia; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Humans; Ibup | 1982 |
Diplopia following ibuprofen administration.
Topics: Arthritis, Rheumatoid; Diplopia; Female; Humans; Ibuprofen; Middle Aged | 1982 |
Nonsteroidal anti-inflammatory drugs.
Topics: Adrenal Cortex Hormones; Analgesics; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Gold; | 1982 |
Cognitive dysfunction associated with naproxen and ibuprofen in the elderly.
Topics: Aged; Arthritis, Rheumatoid; Cognition Disorders; Female; Humans; Ibuprofen; Joint Diseases; Male; N | 1982 |
[Effect of the immunodepressants chrisanol, brufen and indomethacin on synovial membrane permeability in rheumatoid arthritis].
Topics: Adult; Arthritis, Rheumatoid; Capillary Permeability; Cell Membrane Permeability; Dimercaprol; Drug | 1982 |
Current review and comparison of the new nonsteroidal anti-inflammatory agents.
Topics: Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Drug Administration Schedule; Fenoprofen | 1980 |
Nonsteroidal anti-inflammatory drugs for rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Costs and Cost Analysis; Humans; Ibuprofen | 1980 |
Quantitation of ibuprofen in biological fluids by gas chromatography--mass spectrometry.
Topics: Arthritis, Rheumatoid; Gas Chromatography-Mass Spectrometry; Humans; Ibuprofen; Synovial Fluid | 1980 |
Ionised calcium in rheumatoid arthritis: effect of non-steroidal anti-inflammatory drugs.
Topics: Adult; Arthritis, Rheumatoid; Calcium; Female; Humans; Ibuprofen; Male; Time Factors | 1980 |
[Hematotoxic lesions caused by non-steroidal antirheumatic agents].
Topics: Adult; Aged; Agranulocytosis; Anemia, Aplastic; Arthritis, Rheumatoid; Aspirin; Diclofenac; Female; | 1980 |
Serum cytidine deaminase as a measure of disease activity in rheumatoid arthritis and systemic lupus erythematosus.
Topics: Adult; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Cytidine Deaminase; Female; H | 1993 |
Reevaluation of some double-blind, randomized studies of dexibuprofen (Seractil): a state-of-the-art overview. Studies in patients with lumbar vertebral column syndrome, rheumatoid arthritis, distortion of the ankle joint, gonarthrosis, ankylosing spondyl
Topics: Ankle Joint; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Double-Blind Method; Hu | 1996 |
Ibuprofen-induced aseptic meningitis in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Hypertension; Ibuprofen; Mal | 1997 |
Abuse of pain relievers for arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Humans; Ibuprofen; Male; Middle Aged | 1997 |
[Topical administration is better than oral administration].
Topics: Administration, Oral; Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, R | 2001 |
Treatment of collagen induced arthritis by proteolytic enzymes: immunomodulatory and disease modifying effects.
Topics: Animals; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Ibupro | 2001 |
Are selective COX 2 inhibitors superior to traditional non steroidal anti-inflammatory drugs?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Celecoxib; Cyclooxygenase | 2002 |
[Therapeutic effectiveness and tolerability of p-isobutylphenylpropionate of lysine, in parenteral administration, in subjects with hyperalgic forms of rheumatic arthropathy].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Back Pain; Brachial Plexus Neuritis; F | 1979 |
[Ibuprofen tablets à 400 mg in the long-term therapy of progressive polyarthritis].
Topics: Arthritis, Rheumatoid; Female; Humans; Ibuprofen; Long-Term Care; Male; Middle Aged; Tablets | 1978 |
Experience with high doses of ibuprofen in the long-term treatment of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Female; Humans; Ibuprofen; Long-Term Care; Male; Middle Aged | 1978 |
[Clinical observations with a preparation with a base of 4-isobutylphenyl-2-propionate of lysine in degenerative rheumatic diseases].
Topics: Adult; Aged; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Evaluation; Female; Humans; Ibupr | 1979 |
The new anti-inflammatory agents: phenylalkanoic acids.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Ibuprofen; Naproxen; Phenylpropionates | 1976 |
New non-steroidal anti-inflammatory drugs.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Fenoprofen; Humans; Ibuprofen; Naproxen; Penicillam | 1977 |
Analgesic and anti-inflammatory properties of indoprofen.
Topics: Arthritis, Rheumatoid; Aspirin; Humans; Ibuprofen; Indoprofen; Phenylpropionates | 1979 |
[Clinical evaluation of ibuprofen in suspension].
Topics: Adult; Arthritis, Rheumatoid; Chemical Phenomena; Chemistry; Drug Evaluation; Female; Humans; Ibupro | 1979 |
Comparisons of tolerability findings in international clinical trials.
Topics: Arthritis, Rheumatoid; Aspirin; Cardiovascular System; Clinical Trials as Topic; Diclofenac; Drug To | 1979 |
Nonsteroidal antiinflammatory drugs: new alternatives for rheumatic disease.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Fenoprofen; Humans; Ibup | 1978 |
[Antirheumatic non-steroid drugs in the treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Evaluation; Humans; Ibuprofen; Indome | 1978 |
[Effectiveness and pharmacological effect of a new non-steroid drug tosiben in the treatment of rheumatic diseases].
Topics: Arthritis, Rheumatoid; Aspirin; Drug Evaluation; Humans; Hydroxybenzoates; Ibuprofen; Rheumatic Feve | 1978 |
[Sulindac in arthrosis and rheumatoid arthritis].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Ibuprofen; Indenes; Joint Diseases; Sulinda | 1978 |
Concentrations of ibuprofen in serum and synovial fluid from patients with arthritis [proceedings].
Topics: Arthritis, Rheumatoid; Humans; Ibuprofen; Synovial Fluid; Time Factors | 1978 |
Rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Aurothioglucose; Cyclophosphamide; Female; Gold Sodium Thiomalate; H | 1975 |
Prostaglandin synthetase activity from human rheumatoid synovial microsomes. Effect of 'aspirin-like' drug therapy.
Topics: Adult; Aged; Arachidonic Acids; Arthritis, Rheumatoid; Aspirin; Cyclooxygenase Inhibitors; Female; H | 1976 |
Aspirin and newer anti-inflammatory agents in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Indomethaci | 1977 |
Observations on the gastric mucosa of rheumatic patients before and after ibuprofen administration as studied by the pentagastrin test, endoscopy, and light and electron microscopy.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Gastric Juice; Gastric Mucosa; Gastroscopy; Humans; | 1977 |
The treatment of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Child; Chloroquine; Female; Gold; Humans; Hydroxychl | 1977 |
New nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Fenoprofen; Humans; Ibuprofen; Na | 1976 |
Medical management of rheumatoid arthritis.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Chloroquine; Gold; Humans; Ibuprofen; Indom | 1976 |
Nonsteroidal anti-inflammatory drugs.
Topics: Arthritis, Rheumatoid; Humans; Ibuprofen; Osteoarthritis; Phenylpropionates | 1976 |
[Various problems of drug treatment of rheumatoid arthritis].
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Butadienes; Drug Evaluation; Humans; Ibupr | 1976 |
Rheumatic diseases. 2. Therapeutic considerations.
Topics: Adrenal Cortex Hormones; Arthritis, Rheumatoid; Aspirin; Calcinosis; Carpal Tunnel Syndrome; Colchic | 1976 |
Evaluation of ibuprofen (Motrin). A new antirheumatic agent.
Topics: Administration, Oral; Arthritis, Rheumatoid; Aspirin; Central Nervous System; Digestive System; Drug | 1975 |
[Evaluation of the effectiveness of antirheumatic preparations].
Topics: Acetaminophen; Adult; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Drug Evaluation; Fem | 1975 |
[Anti-inflammatory action of 2-(2-fluoro-4-biphenylyl) propionic acid (flubiprofen].
Topics: Animals; Arthritis, Rheumatoid; Capillary Permeability; Edema; Erythema; Flurbiprofen; Granuloma; Gu | 1975 |
Letter: Ibuprofen and visual function.
Topics: Aged; Arthritis, Rheumatoid; Aspirin; Eye; Female; Humans; Ibuprofen; Osteoarthritis; Phenylpropiona | 1976 |
Letter: Agranulocytosis and aplastic anemia possibly due to ibuprofen.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Arthritis, Rheumatoid; Female; Humans; Ibuprofen; Phenylpro | 1976 |
An ophthalmic study of ibuprofen in rheumatoid conditions.
Topics: Adult; Amblyopia; Arthritis, Rheumatoid; Eye; Female; Humans; Ibuprofen; Male; Middle Aged; Phenylpr | 1976 |
[Ibuprofen--successful in activated arthrosis. Results of a administration study].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Human | 1992 |
The effects of a salicylate, ibuprofen, and naproxen on the disposition of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Blood Proteins; Choline; Fema | 1992 |
[Tolerance of ibuprofen. Controlled drug monitoring for the detection of rare side effects].
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Combined Modality Therapy; Female; Humans; Ib | 1991 |
Lack of significant interaction between low dose methotrexate and ibuprofen or flurbiprofen in patients with arthritis.
Topics: Administration, Oral; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Flurbiprofen; Humans; | 1990 |
Lofgren's syndrome (acute sarcoidosis) sine erythema nodosum mimicking acute rheumatoid arthritis.
Topics: Acute Disease; Adult; Arthritis; Arthritis, Rheumatoid; Diagnosis, Differential; Erythema Nodosum; F | 1990 |
Pharmacokinetics of S(+)- and R(-)-ibuprofen in volunteers and first clinical experience of S(+)-ibuprofen in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Biological Availability; Biotransformation; Half-Life; Humans; Ibuprof | 1990 |
Pharmacological differences between R(-)- and S(+)-ibuprofen.
Topics: Administration, Oral; Adult; Aged; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Fema | 1989 |
On the treatment of rheumatoid arthritis with M&Ms (Motrin & methotrexate)
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Humans; Ibuprofen; Methotrexate | 1988 |
Therapeutic efficacy and gastric tolerance of ibuprofen (Brufen) at 1600-2400 mg dosage in rheumatoid arthritis.
Topics: Adult; Arthritis, Rheumatoid; Female; Gastric Mucosa; Humans; Ibuprofen; Male; Stomach Ulcer | 1987 |
[Granulated ibuprofen in rheumatoid arthritis. Comparison of its efficacy and tolerability with naproxen].
Topics: Adult; Aged; Arthritis, Rheumatoid; Dosage Forms; Drug Evaluation; Female; Humans; Ibuprofen; Male; | 1986 |
NSAID-plasma concentration monitoring--optimizing treatment of R.A.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Humans; Ibuprofen | 1985 |
Ibuprofen-associated pure white-cell aplasia.
Topics: Adult; Aged; Agranulocytosis; Antibodies; Arthritis, Rheumatoid; Bone Marrow Diseases; Complement Sy | 1986 |
Ibuprofen kinetics in plasma and synovial fluid of arthritic patients.
Topics: Adult; Aged; Arthritis, Rheumatoid; Blood Proteins; Humans; Ibuprofen; Kinetics; Male; Middle Aged; | 1986 |
Diclofenac sodium in the treatment of rheumatoid arthritis and osteoarthritis.
Topics: Arthritis, Rheumatoid; Aspirin; Diclofenac; Double-Blind Method; Female; Humans; Ibuprofen; Male; Mi | 1985 |