Page last updated: 2024-10-28

ibuprofen and Anxiety

ibuprofen has been researched along with Anxiety in 10 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Anxiety: Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.

Research Excerpts

ExcerptRelevanceReference
" One arm was given sugar-free chewing gum and the other arm ibuprofen for pain relief."9.24Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety. ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017)
"Group A, receiving ibuprofen before and after separator placement, experienced significantly less pain (P <0."9.14Effects of preoperative ibuprofen on pain after separator placement. ( Fillingim, R; Logan, H; Marris, CK; McGorray, SP; Minor, V; Wheeler, TT; Yezierski, R, 2009)
"The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors."8.02The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021)
"To assess pain-management using auricular acupuncture as an adjunct to ibuprofen and paracervical block during first trimester uterine aspiration, and to assess auricular acupuncture's effect on anxiety."5.30Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial. ( Danvers, A; Gold, MA; Morrow, L; Ndubisi, C; Westhoff, CL, 2019)
" One arm was given sugar-free chewing gum and the other arm ibuprofen for pain relief."5.24Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety. ( Atack, NE; Bradley, R; Deacon, S; Ellis, P; Ewings, P; Griffiths, H; House, K; Ireland, AJ; Jordan, A; Moore, MB; Sandy, JR; Scaysbrook, E; Wenger, N; Williams, JC; Worth, V, 2017)
"Group A, receiving ibuprofen before and after separator placement, experienced significantly less pain (P <0."5.14Effects of preoperative ibuprofen on pain after separator placement. ( Fillingim, R; Logan, H; Marris, CK; McGorray, SP; Minor, V; Wheeler, TT; Yezierski, R, 2009)
"The findings showed that ibuprofen significantly improved mice's performance in the passive avoidance test and reduced anxiety- and depressive-like behaviors."4.02The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice. ( Baghcheghi, Y; Hosseini, M; Salmani, H; Samadi-Noshahr, Z, 2021)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's5 (50.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Bahrami, T1
Yaghmaei, P1
Yousofvand, N1
Chen, ZJ3
Su, CW3
Xiong, S3
Li, T3
Liang, HY3
Lin, YH3
Chang, L3
Wu, HY3
Li, F4
Zhu, DY3
Luo, CX3
Salmani, H1
Hosseini, M1
Baghcheghi, Y1
Samadi-Noshahr, Z1
Ndubisi, C1
Danvers, A1
Gold, MA1
Morrow, L1
Westhoff, CL2
Shang, L1
Xu, TL1
Su, J1
Li, WG1
Ireland, AJ1
Ellis, P1
Jordan, A1
Bradley, R1
Ewings, P1
Atack, NE1
Griffiths, H1
House, K1
Moore, MB1
Deacon, S1
Wenger, N1
Worth, V1
Scaysbrook, E1
Williams, JC1
Sandy, JR1
Minor, V1
Marris, CK1
McGorray, SP1
Yezierski, R1
Fillingim, R1
Logan, H1
Wheeler, TT1
Rudin, A1
Eriksson, L1
Liedholm, R1
List, T1
Werner, MU1
Guerrero, JM1
CastaƱo, PM1
Schmidt, EO1
Rosario, L1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Auriculotherapy as an Adjunct for Pain Management During Medication Abortion: a Randomized, Double-blinded, Three-arm Trial[NCT03900728]138 participants (Actual)Interventional2019-04-01Completed
Auriculotherapy as an Adjunct for Pain Management During First Trimester Vacuum Aspiration Abortion: a Randomized, Double-blinded, Three Arm Trial[NCT03896022]177 participants (Actual)Interventional2019-03-28Completed
Auricular Acupuncture as Adjunct for Pain Management During First Trimester Uterine Aspiration.[NCT03391986]153 participants (Actual)Interventional2017-09-09Completed
Efficacy of Combined Ibuprofen and Acetaminophen Therapy Versus Ibuprofen Alone Versus Placebo Alone for Pain of Initial Orthodontic Wire Insertion: a Randomized Controlled Trial[NCT04059172]Early Phase 1375 participants (Anticipated)Interventional2019-12-10Recruiting
Music to Reduce Patient Reported Pain During Intrauterine Device (IUD) Placement in the Office[NCT05068245]96 participants (Actual)Interventional2020-08-28Completed
Music as an Auxiliary Analgesic and Anxiolytic During First Trimester Abortion[NCT01013363]106 participants (Actual)Interventional2009-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Anxiety VAS Score

Self-assessed maximum anxiety reported using a 0-100 mm visual analog scale, where 100 signifies maximum anxiety. (NCT03900728)
Timeframe: Auriculotherapy is applied on the day of mifepristone. Participants take misoprostol 1-3 days later. Anxiety scores are recorded following misoprostol at 8pm x 4 days (selecting the highest of 4 for analysis).

Interventionscore on a scale (Median)
Auriculotherapy With Needles (Acupuncture) + Usual Care45
Auriculotherapy With Gold Beads (Acupressure) + Usual Care10
Placebo Group + Usual Care30

Pain VAS Score

Self-assessed maximum pain reported using a 0-100 mm visual analog scale (VAS), where 100 signifies maximum pain. (NCT03900728)
Timeframe: Auriculotherapy is applied on the day of mifepristone. Participants take misoprostol 1-3 days later. Pain scores are recorded following misoprostol at 8pm x 4 days (selecting the highest of the 4 for analysis).

Interventionscore on a scale (Median)
Auriculotherapy With Needles (Acupuncture) + Usual Care75
Auriculotherapy With Gold Beads (Acupressure) + Usual Care60
Placebo Group + Usual Care55

Anxiety Visual Analog Scale Score

Self-assessed maximum anxiety reported using a 0-100 mm visual analog scale, where 100 signifies maximum anxiety. To measure anxiety during aspiration abortion. (NCT03896022)
Timeframe: Immediately following the aspiration abortion procedure (approximately 10 minutes)

Interventionscore on a scale (Median)
Auriculotherapy - Acupressure With Gold Beads26
Auriculotherapy - Acupuncture With Pyonex Needles28
Placebo Group21

Pain Visual Analog Scale Score (Beads vs Placebo)

Self-assessed maximum pain reported using a 0-100mm visual analog scale, where 100 signifies maximum pain. To measure pain experienced during aspiration abortion. (NCT03896022)
Timeframe: Immediately following the aspiration abortion procedure (approximately 10 minutes)

Interventionscore on a scale (Median)
Auriculotherapy - Acupressure With Gold Beads50
Placebo Group47.5

Pain Visual Analog Scale Score (Needles vs Placebo)

Self-assessed maximum pain reported using a 0-100mm visual analog scale, where 100 signifies maximum pain. To measure pain experienced during aspiration abortion. (NCT03896022)
Timeframe: Immediately following the aspiration abortion procedure (approximately 10 minutes)

Interventionscore on a scale (Median)
Auriculotherapy - Acupuncture With Pyonex Needles55
Placebo Group47.5

Change in Visual Analog Scale for Pain (VAS Pain) Score - Placebo Versus Routine Care

Measure effectiveness of placebo as an adjunct to ibuprofen and paracervical block for pain control during uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive placebo adhesives and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). (NCT03391986)
Timeframe: prior to the procedure (baseline), at the completion of the procedure (approximately 10 minutes later)

Interventionscore on a scale (Mean)
Placebo Adhesives70.0
Routine Care71.0

Percentage of Patients Rated Good or Very Good on Satisfaction Survey in Overall Care - Acupuncture Versus Routine Care

Using a satisfaction survey (investigator-developed, 6 questions, each question is graded on a scale of 1-5, 1 being very poor and 5 being very good) to measure effectiveness of auricular acupuncture for improving satisfaction. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 5-10 minutes)

Interventionpercentage of participants (Number)
Pyonex Needles94
Routine Care76

Visual Analog Scale for Pain (VAS Pain) Score - Acupuncture Versus Routine Care

Measure effectiveness of auricular acupuncture as an adjunct to ibuprofen and paracervical block for pain control during first trimester uterine aspiration by comparing the maximum pain score; as measured by VAS between women randomized to receive auricular acupuncture and routine care controls - using a 100 mm visual analog scale (VAS-P) (anchors: 0 mm = no pain, 100 mm = worst pain in my life). The VAS has no sub-scales. (NCT03391986)
Timeframe: at the completion of the procedure (approximately 10 minutes later)

Interventionscore on a scale (Mean)
Pyonex Needles39.5
Routine Care71.0

Reviews

1 review available for ibuprofen and Anxiety

ArticleYear
Evidence-based review of clinical studies on pharmacology (non-anesthetic studies).
    Journal of endodontics, 2009, Volume: 35, Issue:8

    Topics: Acetaminophen; Administration, Oral; Analgesics; Anxiety; Dental Pulp Diseases; Dexamethasone; Drug

2009

Trials

4 trials available for ibuprofen and Anxiety

ArticleYear
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Auricular acupuncture as an adjunct for pain management during first trimester abortion: a randomized, double-blinded, three arm trial.
    Contraception, 2019, Volume: 99, Issue:3

    Topics: Abortion, Induced; Acupuncture, Ear; Adult; Anesthesia, Obstetrical; Anxiety; Double-Blind Method; F

2019
Chewing gum vs. ibuprofen in the management of orthodontic pain, a multi-centre randomised controlled trial - the effect of anxiety.
    Journal of orthodontics, 2017, Volume: 44, Issue:1

    Topics: Adolescent; Anxiety; Chewing Gum; Child; Humans; Ibuprofen; Pain; Societies, Dental

2017
Effects of preoperative ibuprofen on pain after separator placement.
    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2009, Volume: 136, Issue:4

    Topics: Adolescent; Adult; Affect; Analgesics, Non-Narcotic; Anxiety; Attitude to Health; Dental Occlusion;

2009
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012
Music as an auxiliary analgesic during first trimester surgical abortion: a randomized controlled trial.
    Contraception, 2012, Volume: 86, Issue:2

    Topics: Abortion, Induced; Academic Medical Centers; Adolescent; Adult; Analgesics, Non-Narcotic; Anesthesia

2012

Other Studies

5 other studies available for ibuprofen and Anxiety

ArticleYear
The effects of Ibuprofen and 1, 8- cineol on anxiety and spatial memory in hyperammonemic rats.
    Metabolic brain disease, 2023, Volume: 38, Issue:2

    Topics: Animals; Anxiety; Eucalyptol; Hippocampus; Hyperammonemia; Ibuprofen; Oxidative Stress; Rats; Rats,

2023
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:5

    Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex;

2023
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:5

    Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex;

2023
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:5

    Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex;

2023
Enhanced AMPAR-dependent synaptic transmission by S-nitrosylation in the vmPFC contributes to chronic inflammatory pain-induced persistent anxiety in mice.
    Acta pharmacologica Sinica, 2023, Volume: 44, Issue:5

    Topics: Animals; Anxiety; Anxiety Disorders; Chronic Pain; Ibuprofen; Inflammation; Mice; Prefrontal Cortex;

2023
The brain consequences of systemic inflammation were not fully alleviated by ibuprofen treatment in mice.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:1

    Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anxiety; Behavior, Animal;

2021
Temporal dynamics of anxiety phenotypes in a dental pulp injury model.
    Molecular pain, 2015, Jun-30, Volume: 11

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anxiety; Behavior, Animal; Dental Pulp; Disease Model

2015
Prediction of postoperative pain after mandibular third molar surgery.
    Journal of orofacial pain, 2010,Spring, Volume: 24, Issue:2

    Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anxiety; Attitude; Depression; Eating; Female; Follo

2010