Page last updated: 2024-10-28

ibuprofen and Anoxemia

ibuprofen has been researched along with Anoxemia in 34 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia."9.69Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023)
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."7.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension."7.67Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985)
"The purpose of this study was to evaluate the effects of acute ibuprofen consumption (2 × 600-mg doses) on markers of enterocyte injury, intestinal barrier dysfunction, inflammation, and symptoms of gastrointestinal (GI) distress at rest and after exercise in hypobaric hypoxia."5.69Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia. ( Amorim, FT; Berkemeier, QN; Deyhle, MR; Ducharme, JB; Fennel, ZJ; Gillum, TL; McKenna, ZJ; Mermier, CM; Specht, JW, 2023)
" Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings."5.43Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016)
"Melatonin was administered to another group of mice as a potent ROS scavenger."5.37Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011)
" As inflammation has been involved in CIH-induced hypertension and chemosensory potentiation, we tested whether ibuprofen may block CB chemosensory and cardiorespiratory alterations induced by CIH in a rat model of OSA."3.78Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia. ( Del Rio, R; Iturriaga, R; Madrid, C; Moya, EA; Parga, MJ, 2012)
" Recently, we gave L-lysine ibuprofen to a preterm infant with respiratory distress to induce closure of a patent ductus arteriosus, and the infant experienced pulmonary hypertension."3.73Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus. ( Bellini, C; Campone, F; Serra, G, 2006)
"The effectiveness of diltiazem, a slow channel calcium blocker, ibuprofen, a nonselective inhibitor of prostanoid synthesis, and the selective inhibition of thromboxane A2 with imidazole and UK-38,485 in retarding the development of right ventricular (RV) hypertrophy was assessed in a rat model of chronic hypoxic pulmonary hypertension."3.67Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension. ( Reeves, WC; Schildt, N; Whitesell, L; Wood, MA, 1985)
"In anesthetized dogs ethchlorvynol (ECV, 9 mg/kg) was selectively administered into the right pulmonary circulation to produce unilateral acute lung injury (ALI) characterized by nonhydrostatic pulmonary edema and systemic hypoxemia."3.67Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs. ( Dahms, TE; Lonigro, AJ; Sprague, RS; Stephenson, AH, 1986)
"The effect of halothane on the pressor responses to hypoxia (3% O2, 5% CO2, balance N2) and to Angiotensin II (Ang II) (0."3.67The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction. ( Kim, SD; Marshall, BE; Marshall, C, 1987)
" Increased mean retention time, Vd, T½ of ibuprofen, and decreased AUC, Cmax and clearance during CHH further strengthened the present findings."1.43Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude. ( Gola, S; Gupta, A; Keshri, GK; Nath, M; Velpandian, T, 2016)
"Ibuprofen blocked the increase in hypoxic ventilation observed in chronically hypoxic rats treated with saline; ibuprofen had no effects on ventilation in normoxic control rats."1.37Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats. ( Fu, Z; Go, A; Popa, D; Powell, FL, 2011)
"Melatonin was administered to another group of mice as a potent ROS scavenger."1.37Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin. ( Bustos-Obregón, E; Hartley, R; Vargas, A, 2011)
"Rats treated with ibuprofen after transient forebrain ischemia displayed long-lasting protection of CA1 hippocampal neurons."1.33Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression. ( Cho, BP; Cho, S; Cruz, MO; Joh, TH; Park, EM; Volpe, BT, 2005)
"The absence of hypoxemia (including a normal alveolar-arterial oxygen difference) in our patient with a massive pulmonary embolus may have been related to cyclooxygenase inhibition due to ibuprofen, with improvement in ventilation-perfusion mismatch."1.33Massive pulmonary embolus without hypoxemia. ( Baird, JS; Greene, A; Schleien, CL, 2005)
"All rabbits were subjected to stepwise cardiac tamponade by inflation of a handmade balloon placed into the pericardial sac to reduce DO2."1.32Effect of Ibuprofen on interleukin-1beta-induced abnormalities in hemodynamics and oxygen metabolism in rabbits. ( Irisawa, T; Kuwagata, Y; Matsuyama, S; Nakamori, Y; Oda, J; Sugimoto, H; Takahashi, M, 2003)
"Ibuprofen treatment (30 mg/kg) had no effect on pial arteriolar diameter during normoxia or hypoxia, and pretreatment did not alter dilation to hypoxia."1.30Cerebral arteriolar dilation to hypoxia: role of prostanoids. ( Leffler, CW; Parfenova, H, 1997)
"Ibuprofen pretreatment did not alter ED50 and slope of dose-response curve, although the absolute value of pressor response in the sevoflurane group with ibuprofen pretreatment was greater than that in the sevoflurane alone group at every concentration of sevoflurane."1.29Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung. ( Gui, X; Ishibe, Y; Shiokawa, Y; Suekane, K; Umeda, T; Uno, H, 1993)

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-199011 (32.35)18.7374
1990's3 (8.82)18.2507
2000's7 (20.59)29.6817
2010's10 (29.41)24.3611
2020's3 (8.82)2.80

Authors

AuthorsStudies
McKenna, ZJ1
Ducharme, JB1
Berkemeier, QN1
Specht, JW1
Fennel, ZJ1
Gillum, TL1
Deyhle, MR1
Amorim, FT1
Mermier, CM1
Ernst, C1
Bek, T1
Bavis, RW1
Song, MJ1
Smachlo, JP1
Hulse, A1
Kenison, HR1
Peralta, JN1
Place, JT1
Triebwasser, S1
Warden, SE1
McDonough, AB1
De La Zerda, DJ1
Stokes, JA1
Do, J1
Go, A2
Fu, Z2
Powell, FL3
Basaran, KE1
Villongco, M1
Ho, B1
Ellis, E1
Zarndt, R1
Antonova, J1
Hopkins, SR1
Gola, S2
Gupta, A2
Keshri, GK2
Nath, M1
Velpandian, T1
Liu, X2
He, L2
Stensaas, L1
Dinger, B2
Fidone, S1
Popa, D1
Fidone, SJ1
Del Rio, R2
Moya, EA2
Parga, MJ1
Madrid, C1
Iturriaga, R2
Lam, SY1
Liu, Y1
Ng, KM1
Lau, CF1
Liong, EC1
Tipoe, GL1
Fung, ML1
Vargas, A1
Bustos-Obregón, E1
Hartley, R1
Schmidt, B1
Wright, LL1
Davis, P1
Solimano, A1
Roberts, RS1
Palayoor, ST1
Tofilon, PJ1
Coleman, CN1
Kuwagata, Y1
Oda, J1
Irisawa, T1
Matsuyama, S1
Nakamori, Y1
Takahashi, M1
Sugimoto, H1
Park, EM1
Cho, BP1
Volpe, BT1
Cruz, MO1
Joh, TH1
Cho, S1
Baird, JS1
Greene, A1
Schleien, CL1
Bellini, C1
Campone, F1
Serra, G1
Perkowski, SZ1
Havill, AM1
Flynn, JT1
Gee, MH1
Ishibe, Y1
Gui, X1
Uno, H1
Shiokawa, Y1
Umeda, T1
Suekane, K1
Leffler, CW1
Parfenova, H1
Coceani, F1
Olley, PM1
Bishai, I1
Bodach, E1
Heaton, J1
Nashat, M1
White, E1
Johnson, D1
Hurst, T1
To, T1
Mayers, I1
Reeves, WC1
Wood, MA1
Whitesell, L1
Schildt, N1
Sprague, RS2
Stephenson, AH2
Dahms, TE2
Lonigro, AJ2
Marshall, C1
Kim, SD1
Marshall, BE1
Wagner, EM1
Mitzner, WA1
Calvin, JE1
Dervin, G1
Newman, JH1
Butka, BJ1
Brigham, KL1
Mashkovskiĭ, MD1
Bobkov, IuG1
Shvarts, GIa1
Ivanova, IA1
Asner, NG1
Wenger, H1
Wong, C1
Demling, RH1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Pilot Clinical Trial of the Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction of Sevoflurane in Patient's Whit ARDS Secondary to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2)[NCT04998253]Early Phase 124 participants (Actual)Interventional2020-10-01Completed
Liberal Versus Restrictive Platelet Transfusion for Treatment of Hemodynamically Significant Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates- A Randomized Open Label, Controlled Trial[NCT03022253]Phase 344 participants (Anticipated)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

3 trials available for ibuprofen and Anoxemia

ArticleYear
Ibuprofen Increases Markers of Intestinal Barrier Injury But Suppresses Inflammation at Rest and After Exercise in Hypoxia.
    Medicine and science in sports and exercise, 2023, 01-01, Volume: 55, Issue:1

    Topics: Adult; Chemokine CCL2; Exercise; Gastrointestinal Diseases; Humans; Hypoxia; Ibuprofen; Inflammation

2023
Ibuprofen Blunts Ventilatory Acclimatization to Sustained Hypoxia in Humans.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Acclimatization; Adolescent; Adult; Altitude; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body;

2016
Ibuprofen prophylaxis in preterm neonates.
    Lancet (London, England), 2002, Aug-10, Volume: 360, Issue:9331

    Topics: Cyclooxygenase Inhibitors; Ductus Arteriosus, Patent; Humans; Hypertension, Pulmonary; Hypoxia; Ibup

2002

Other Studies

31 other studies available for ibuprofen and Anoxemia

ArticleYear
Differential effects of purines and prostaglandins on hypoxia induced dilatation of porcine retinal vessels at different branching level ex vivo.
    Experimental eye research, 2023, Volume: 234

    Topics: Adenosine; Animals; Dilatation; Hypoxia; Ibuprofen; Prostaglandins; Retinal Vessels; Swine

2023
Ventilatory and carotid body responses to acute hypoxia in rats exposed to chronic hypoxia during the first and second postnatal weeks.
    Respiratory physiology & neurobiology, 2020, Volume: 275

    Topics: Age Factors; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Femal

2020
Ibuprofen does not reverse ventilatory acclimatization to chronic hypoxia.
    Respiratory physiology & neurobiology, 2018, Volume: 256

    Topics: Acclimatization; Analysis of Variance; Animals; Calcium-Binding Proteins; Cyclooxygenase Inhibitors;

2018
Evaluation of hepatic metabolism and pharmacokinetics of ibuprofen in rats under chronic hypobaric hypoxia for targeted therapy at high altitude.
    Journal of pharmaceutical and biomedical analysis, 2016, Mar-20, Volume: 121

    Topics: Altitude; Animals; Area Under Curve; Cytochrome P-450 CYP2C9; Cytokines; Down-Regulation; Hypoxia; I

2016
Adaptation to chronic hypoxia involves immune cell invasion and increased expression of inflammatory cytokines in rat carotid body.
    American journal of physiology. Lung cellular and molecular physiology, 2009, Volume: 296, Issue:2

    Topics: Adaptation, Physiological; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carotid Body; Chronic D

2009
Ibuprofen blocks time-dependent increases in hypoxic ventilation in rats.
    Respiratory physiology & neurobiology, 2011, Sep-30, Volume: 178, Issue:3

    Topics: Animals; Hypoxia; Ibuprofen; Male; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Time Factors

2011
Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:6

    Topics: Acid Sensing Ion Channels; Action Potentials; Animals; Anti-Inflammatory Agents, Non-Steroidal; Caro

2011
Carotid body inflammation and cardiorespiratory alterations in intermittent hypoxia.
    The European respiratory journal, 2012, Volume: 39, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cardiovascular System; Carotid Bod

2012
Chronic intermittent hypoxia induces local inflammation of the rat carotid body via functional upregulation of proinflammatory cytokine pathways.
    Histochemistry and cell biology, 2012, Volume: 137, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Carotid Artery,

2012
Effects of hypoxia on epididymal sperm parameters and protective role of ibuprofen and melatonin.
    Biological research, 2011, Volume: 44, Issue:2

    Topics: Altitude; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Epididymis; Hematocrit; Hy

2011
Contribution of inflammation on carotid body chemosensory potentiation induced by intermittent hypoxia.
    Advances in experimental medicine and biology, 2012, Volume: 758

    Topics: Animals; Carotid Body; Hypoxia; Ibuprofen; Inflammation; Interleukin-1beta; Rats; Transcription Fact

2012
Hepatic metabolism of ibuprofen in rats under acute hypobaric hypoxia.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2013, Volume: 65, Issue:6

    Topics: Acute Disease; Altitude; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytochrome P-450 Enzyme S

2013
Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2003, Aug-01, Volume: 9, Issue:8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tu

2003
Effect of Ibuprofen on interleukin-1beta-induced abnormalities in hemodynamics and oxygen metabolism in rabbits.
    Shock (Augusta, Ga.), 2003, Volume: 20, Issue:6

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Gas Analysis;

2003
Ibuprofen protects ischemia-induced neuronal injury via up-regulating interleukin-1 receptor antagonist expression.
    Neuroscience, 2005, Volume: 132, Issue:3

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain Isc

2005
Massive pulmonary embolus without hypoxemia.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2005, Volume: 6, Issue:5

    Topics: Adolescent; Cyclooxygenase Inhibitors; Drug Administration Schedule; Humans; Hypoxia; Ibuprofen; Mal

2005
Pulmonary hypertension following L-lysine ibuprofen therapy in a preterm infant with patent ductus arteriosus.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006, Jun-20, Volume: 174, Issue:13

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Fatal Outcome; Humans; Hypertens

2006
Role of intrapulmonary release of eicosanoids and superoxide anion as mediators of pulmonary dysfunction and endothelial injury in sheep with intermittent complement activation.
    Circulation research, 1983, Volume: 53, Issue:5

    Topics: Animals; Capillary Permeability; Chemotaxis, Leukocyte; Complement Activation; Endothelium; Hyperten

1983
Effect of sevoflurane on hypoxic pulmonary vasoconstriction in the perfused rabbit lung.
    Anesthesiology, 1993, Volume: 79, Issue:6

    Topics: Anesthetics; Animals; Dose-Response Relationship, Drug; Ethers; Female; Hypoxia; Ibuprofen; Isoflura

1993
Cerebral arteriolar dilation to hypoxia: role of prostanoids.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Animals, Newborn; Arterioles; Cerebrovascular Circulation; Hy

1997
Prostaglandins and the control of muscle tone in the ductus arteriosus.
    Advances in experimental medicine and biology, 1977, Volume: 78

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Ductus Arteriosus; Gestational Age; Glu

1977
Interactions of endotoxin, prostaglandins, and circulating cells upon pulmonary vascular resistance.
    Circulatory shock, 1992, Volume: 36, Issue:1

    Topics: Animals; Blood Platelets; Dogs; Endotoxins; Granulocytes; Hemodynamics; Hypoxia; Ibuprofen; In Vitro

1992
Effect of diltiazem and ibuprofen on right ventricular hypertrophy in an experimental model of hypoxic pulmonary hypertension.
    The American journal of cardiology, 1985, Sep-01, Volume: 56, Issue:7

    Topics: Animals; Benzazepines; Cardiomegaly; Diltiazem; Hypertension, Pulmonary; Hypoxia; Ibuprofen; Imidazo

1985
Effect of cyclooxygenase inhibition on ethchlorvynol-induced acute lung injury in dogs.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 61, Issue:3

    Topics: Animals; Body Water; Cyclooxygenase Inhibitors; Disease Models, Animal; Dogs; Ethchlorvynol; Hypoxia

1986
The actions of halothane, ibuprofen and BW755C on hypoxic pulmonary vasoconstriction.
    Anesthesiology, 1987, Volume: 66, Issue:4

    Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Angiotensin II; Animals; Arachidonic A

1987
Effect of hypoxia on bronchial circulation.
    Journal of applied physiology (Bethesda, Md. : 1985), 1988, Volume: 65, Issue:4

    Topics: Animals; Blood Flow Velocity; Blood Pressure; Bronchi; Bronchial Arteries; Hypoxia; Ibuprofen; Indom

1988
Intravenous ibuprofen blocks the hypoxemia of pulmonary glass bead embolism in the dog.
    Critical care medicine, 1988, Volume: 16, Issue:9

    Topics: Animals; Blood Pressure; Cardiac Output; Dogs; Glass; Hypoxia; Ibuprofen; Oxygen; Partial Pressure;

1988
Thromboxane A2 and prostacyclin do not modulate pulmonary hemodynamics during exercise in sheep.
    Journal of applied physiology (Bethesda, Md. : 1985), 1986, Volume: 61, Issue:5

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Pressure; Cardiac Output; Epoprostenol; Hemodynamics; H

1986
[Experimental study of the antihypoxic properties of ibuprofen and other nonsteroidal anti-inflammatory preparations].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:6

    Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Asphyxia; Drug Evaluation, Preclini

1987
Effects of ibuprofen on the hypoxemia of established ethchlorvynol-induced unilateral acute lung injury in anesthetized dogs.
    Chest, 1987, Volume: 92, Issue:6

    Topics: Animals; Dogs; Ethchlorvynol; Hemodynamics; Hypoxia; Ibuprofen; Lung Diseases; Male

1987
Pulmonary dysfunction secondary to soft-tissue endotoxin.
    Archives of surgery (Chicago, Ill. : 1960), 1985, Volume: 120, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Endotoxins; Escherichia coli; Hypertension, Pulmonary; Hypoxi

1985