Page last updated: 2024-10-28

ibuprofen and Amyloidosis

ibuprofen has been researched along with Amyloidosis in 3 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.

Research Excerpts

ExcerptRelevanceReference
"The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits."5.31Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000)
"Neuritic plaques in the brain of Alzheimer's disease patients are characterized by beta-amyloid deposits associated with a glia-mediated inflammatory response."1.33Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. ( Dewachter, I; Dumitrescu-Ozimek, L; Hanke, A; Heneka, MT; Klockgether, T; Kuiperi, C; Landreth, GE; O'Banion, K; Sastre, M; Van Leuven, F, 2005)
"The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits."1.31Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Morihara, T1
Teter, B2
Yang, F2
Lim, GP2
Boudinot, S1
Boudinot, FD1
Frautschy, SA2
Cole, GM2
Heneka, MT1
Sastre, M1
Dumitrescu-Ozimek, L1
Hanke, A1
Dewachter, I1
Kuiperi, C1
O'Banion, K1
Klockgether, T1
Van Leuven, F1
Landreth, GE1
Chu, T1
Chen, P1
Beech, W1
Tran, T1
Ubeda, O1
Ashe, KH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pioglitazone in Alzheimer Disease Progression[NCT00982202]Phase 225 participants (Actual)Interventional2002-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

3 other studies available for ibuprofen and Amyloidosis

ArticleYear
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005, Volume: 30, Issue:6

    Topics: Acute-Phase Proteins; alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid Precursor Protein Secreta

2005
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
    Brain : a journal of neurology, 2005, Volume: 128, Issue:Pt 6

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Amyloidosis; Animals

2005
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000, Aug-01, Volume: 20, Issue:15

    Topics: Alzheimer Disease; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Mod

2000