ibuprofen has been researched along with Amyloidosis in 3 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Amyloidosis: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits." | 5.31 | Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000) |
| "Neuritic plaques in the brain of Alzheimer's disease patients are characterized by beta-amyloid deposits associated with a glia-mediated inflammatory response." | 1.33 | Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. ( Dewachter, I; Dumitrescu-Ozimek, L; Hanke, A; Heneka, MT; Klockgether, T; Kuiperi, C; Landreth, GE; O'Banion, K; Sastre, M; Van Leuven, F, 2005) |
| "The brain in Alzheimer's disease (AD) shows a chronic inflammatory response characterized by activated glial cells and increased expression of cytokines and complement factors surrounding amyloid deposits." | 1.31 | Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease. ( Ashe, KH; Beech, W; Chen, P; Chu, T; Cole, GM; Frautschy, SA; Lim, GP; Teter, B; Tran, T; Ubeda, O; Yang, F, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morihara, T | 1 |
| Teter, B | 2 |
| Yang, F | 2 |
| Lim, GP | 2 |
| Boudinot, S | 1 |
| Boudinot, FD | 1 |
| Frautschy, SA | 2 |
| Cole, GM | 2 |
| Heneka, MT | 1 |
| Sastre, M | 1 |
| Dumitrescu-Ozimek, L | 1 |
| Hanke, A | 1 |
| Dewachter, I | 1 |
| Kuiperi, C | 1 |
| O'Banion, K | 1 |
| Klockgether, T | 1 |
| Van Leuven, F | 1 |
| Landreth, GE | 1 |
| Chu, T | 1 |
| Chen, P | 1 |
| Beech, W | 1 |
| Tran, T | 1 |
| Ubeda, O | 1 |
| Ashe, KH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pioglitazone in Alzheimer Disease Progression[NCT00982202] | Phase 2 | 25 participants (Actual) | Interventional | 2002-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for ibuprofen and Amyloidosis
| Article | Year |
|---|---|
Ibuprofen suppresses interleukin-1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (Abeta) pathology in Alzheimer's models.
Topics: Acute-Phase Proteins; alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid Precursor Protein Secreta | 2005 |
Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Amyloidosis; Animals | 2005 |
Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloidosis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Disease Mod | 2000 |