ibuprofen has been researched along with Altitude Hypoxia in 24 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
Altitude Hypoxia: Low ambient oxygen tension associated with ALTITUDE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subjects in both the metoclopramide and ibuprofen arms reported reduced headache severity and nausea compared to pretreatment values at 120 min." | 9.34 | Prospective Double-Blinded Randomized Field-Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Altitude Headache and Acute Mountain Sickness. ( Bhai, SF; Gregorie, WD; Harris, NS; Irons, HR; Salas, RN, 2020) |
| "Ibuprofen has been shown to be more effective than placebo in the treatment of high altitude headache (HAH), but nonsteroidal anti-inflammatory agents have been linked to increased incidence of gastrointestinal (GI) side effects and high-altitude pulmonary edema (HAPE)." | 9.10 | High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. ( Harris, NS; Thomas, SH; Wenzel, RP, 2003) |
| "Ibuprofen was slightly inferior to acetazolamide for acute mountain sickness prevention and should not be recommended over acetazolamide for rapid ascent." | 6.90 | Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide. ( Burns, P; Hackett, P; Jurkiewicz, C; Lipman, GS; Phillips, C; Sanders, L; Soto, M; Warner, K, 2019) |
| "Ibuprofen was also superior to placebo in reducing the severity of HAH (4." | 6.77 | Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness. ( Abramson, CH; Basnyat, B; Casto, AM; Chapagain, P; Corbett, B; Farrar, J; Farzan, NN; Gertsch, JH; Holck, PS; Holly, JE; Irons, H; Macguire, C; May, K; Mulcahy, A; Norvelle, RJ; Pun, M; Stillwagon, NT; Stutz, AM; Vaughan, CP; Vo, BN; Watts, M; Yadav, S, 2012) |
| "Ibuprofen was similar to acetazolamide in preventing symptoms of AMS, an interesting finding that implies a potentially new approach to prevention of cerebral forms of acute altitude illness." | 6.75 | Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT). ( Allison, E; Basnyat, B; Fisher, RS; Gertsch, JH; Hanzelka, K; Hazan, A; Holck, PS; Lipman, GS; Merritt, A; Meyers, Z; Mulcahy, A; Odegaard, J; Pook, B; Slomovic, B; Thompson, M; Wahlberg, H; Weiss, EA; Wilshaw, V; Zafren, K, 2010) |
| "Ibuprofen was significantly superior to placebo both in reducing headache severity and in speed of relief (a mean difference of 94 min in time to no/minimal headache)." | 6.67 | High altitude headache: treatment with ibuprofen. ( Beeley, JM; Broome, JR; Hughes, AS; Milledge, JS; Stoneham, MD, 1994) |
| "Subjects in both the metoclopramide and ibuprofen arms reported reduced headache severity and nausea compared to pretreatment values at 120 min." | 5.34 | Prospective Double-Blinded Randomized Field-Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Altitude Headache and Acute Mountain Sickness. ( Bhai, SF; Gregorie, WD; Harris, NS; Irons, HR; Salas, RN, 2020) |
| "Ibuprofen has been shown to be more effective than placebo in the treatment of high altitude headache (HAH), but nonsteroidal anti-inflammatory agents have been linked to increased incidence of gastrointestinal (GI) side effects and high-altitude pulmonary edema (HAPE)." | 5.10 | High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial. ( Harris, NS; Thomas, SH; Wenzel, RP, 2003) |
| "Ibuprofen was slightly inferior to acetazolamide for acute mountain sickness prevention and should not be recommended over acetazolamide for rapid ascent." | 2.90 | Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide. ( Burns, P; Hackett, P; Jurkiewicz, C; Lipman, GS; Phillips, C; Sanders, L; Soto, M; Warner, K, 2019) |
| "Acetaminophen and ibuprofen were tested for AMS prevention." | 2.84 | Prophylactic Acetaminophen or Ibuprofen Results in Equivalent Acute Mountain Sickness Incidence at High Altitude: A Prospective Randomized Trial. ( Basnyat, B; Basyal, B; Freeman, TF; Gehner, JR; Holck, PS; Kanaan, NC; Keyes, L; Levin, DR; O'Leary, CJ; Peterson, AL; Pun, M; Starling, J; Stuart, KE; Thapa, GB; Tiwari, A; Velgersdyk, JL; Zafren, K, 2017) |
| "Ibuprofen was also superior to placebo in reducing the severity of HAH (4." | 2.77 | Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness. ( Abramson, CH; Basnyat, B; Casto, AM; Chapagain, P; Corbett, B; Farrar, J; Farzan, NN; Gertsch, JH; Holck, PS; Holly, JE; Irons, H; Macguire, C; May, K; Mulcahy, A; Norvelle, RJ; Pun, M; Stillwagon, NT; Stutz, AM; Vaughan, CP; Vo, BN; Watts, M; Yadav, S, 2012) |
| "Ibuprofen was similar to acetazolamide in preventing symptoms of AMS, an interesting finding that implies a potentially new approach to prevention of cerebral forms of acute altitude illness." | 2.75 | Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT). ( Allison, E; Basnyat, B; Fisher, RS; Gertsch, JH; Hanzelka, K; Hazan, A; Holck, PS; Lipman, GS; Merritt, A; Meyers, Z; Mulcahy, A; Odegaard, J; Pook, B; Slomovic, B; Thompson, M; Wahlberg, H; Weiss, EA; Wilshaw, V; Zafren, K, 2010) |
| "Ibuprofen was significantly superior to placebo both in reducing headache severity and in speed of relief (a mean difference of 94 min in time to no/minimal headache)." | 2.67 | High altitude headache: treatment with ibuprofen. ( Beeley, JM; Broome, JR; Hughes, AS; Milledge, JS; Stoneham, MD, 1994) |
| "Acute mountain sickness is a common condition occurring in healthy subjects that undergo rapid ascent without prior acclimatization, as low as 2500 meters above sea level." | 2.66 | Ibuprofen versus acetazolamide for prevention of acute mountain sickness. ( Irarrázaval, S; Schilling, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.33) | 18.2507 |
| 2000's | 1 (4.17) | 29.6817 |
| 2010's | 16 (66.67) | 24.3611 |
| 2020's | 5 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Irons, HR | 1 |
| Salas, RN | 1 |
| Bhai, SF | 1 |
| Gregorie, WD | 1 |
| Harris, NS | 2 |
| Schilling, M | 1 |
| Irarrázaval, S | 1 |
| Yi, H | 1 |
| Wang, K | 1 |
| Gan, X | 1 |
| Li, L | 1 |
| Zhang, Q | 1 |
| Xiang, J | 1 |
| Yuan, X | 1 |
| Zhang, Y | 1 |
| Wang, Y | 1 |
| Pun, M | 3 |
| Burns, P | 2 |
| Lipman, GS | 6 |
| Warner, K | 2 |
| Jurkiewicz, C | 2 |
| Phillips, C | 2 |
| Sanders, L | 2 |
| Soto, M | 2 |
| Hackett, P | 2 |
| Kanaan, NC | 4 |
| Peterson, AL | 1 |
| Holck, PS | 6 |
| Starling, J | 1 |
| Basyal, B | 1 |
| Freeman, TF | 1 |
| Gehner, JR | 1 |
| Keyes, L | 1 |
| Levin, DR | 1 |
| O'Leary, CJ | 1 |
| Stuart, KE | 1 |
| Thapa, GB | 1 |
| Tiwari, A | 1 |
| Velgersdyk, JL | 1 |
| Zafren, K | 3 |
| Basnyat, B | 4 |
| Sridharan, K | 1 |
| Sivaramakrishnan, G | 1 |
| Lundeberg, J | 2 |
| Feiner, JR | 2 |
| Schober, A | 1 |
| Sall, JW | 1 |
| Eilers, H | 1 |
| Bickler, PE | 1 |
| Burtscher, M | 2 |
| Bickler, P | 1 |
| Gertsch, JH | 4 |
| Corbett, BM | 1 |
| Lopez, JI | 1 |
| Holdridge, A | 1 |
| Mendizabal, JE | 1 |
| Constance, BB | 2 |
| Preuss, JF | 1 |
| Williams, SR | 1 |
| Ghosh, M | 1 |
| Biswas, D | 1 |
| Mukherjee, A | 1 |
| Manzano, S | 1 |
| Doyon-Trottier, E | 1 |
| Bailey, B | 1 |
| Merritt, A | 1 |
| Mulcahy, A | 2 |
| Fisher, RS | 1 |
| Allison, E | 1 |
| Hanzelka, K | 1 |
| Hazan, A | 1 |
| Meyers, Z | 1 |
| Odegaard, J | 1 |
| Pook, B | 1 |
| Thompson, M | 1 |
| Slomovic, B | 1 |
| Wahlberg, H | 1 |
| Wilshaw, V | 1 |
| Weiss, EA | 1 |
| Corbett, B | 1 |
| Watts, M | 1 |
| Stillwagon, NT | 1 |
| Casto, AM | 1 |
| Abramson, CH | 1 |
| Vaughan, CP | 1 |
| Macguire, C | 1 |
| Farzan, NN | 1 |
| Vo, BN | 1 |
| Norvelle, RJ | 1 |
| May, K | 1 |
| Holly, JE | 1 |
| Irons, H | 1 |
| Stutz, AM | 1 |
| Chapagain, P | 1 |
| Yadav, S | 1 |
| Farrar, J | 1 |
| Wenzel, RP | 1 |
| Thomas, SH | 1 |
| Likar, R | 1 |
| Nachbauer, W | 1 |
| Schaffert, W | 1 |
| Philadelphy, M | 1 |
| Broome, JR | 1 |
| Stoneham, MD | 1 |
| Beeley, JM | 1 |
| Milledge, JS | 1 |
| Hughes, AS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Altitude Sickness Prevention With Ibuprofen Relative to Acetazolamide and Treatment Efficacy[NCT03154645] | Phase 1 | 92 participants (Actual) | Interventional | 2017-08-12 | Completed | ||
| Acute Mountain Sickness Treatment: A Double-blind Comparison of Metoclopramide vs. Ibuprofen[NCT01522326] | 300 participants (Anticipated) | Interventional | 2012-03-01 | Completed | |||
| Prevention of Altitude Illness With Non-steroidal Anti-inflammatory Study (PAINS)[NCT01171794] | Phase 3 | 89 participants (Actual) | Interventional | 2010-07-31 | Completed | ||
| Double Blind, Placebo Controlled Randomised Trial of Acetazolamide Versus Placebo in the Prevention of Acute Mountain Sickness During Rapid Ascent[NCT01418157] | Phase 4 | 380 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Lake Louise Criteria scores range from 0-15 with higher scores representing more severe symptoms; scores of 3 or greater with presence of a headache considered a positive diagnosis of acute mountain sickness (NCT01171794)
Timeframe: 2 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Ibuprofen | 19 |
| Placebo | 26 |
Lake Louise Criteria scores range from 0-15 with higher scores representing more severe symptoms (NCT01171794)
Timeframe: 2 days
| Intervention | units on a scale (Mean) |
|---|---|
| Ibuprofen | 3.2 |
| Placebo | 4.4 |
3 reviews available for ibuprofen and Altitude Hypoxia
| Article | Year |
|---|---|
Ibuprofen versus acetazolamide for prevention of acute mountain sickness.
Topics: Acetazolamide; Acute Disease; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Carbonic A | 2020 |
Altitude headache.
Topics: Acute Disease; Adaptation, Physiological; Altitude; Altitude Sickness; Anti-Inflammatory Agents; Asp | 2013 |
Myth: Ibuprofen is superior to acetaminophen for the treatment of benign headaches in children and adults.
Topics: Acetaminophen; Adolescent; Adult; Altitude Sickness; Analgesics, Non-Narcotic; Child; Headache; Huma | 2010 |
11 trials available for ibuprofen and Altitude Hypoxia
| Article | Year |
|---|---|
Prospective Double-Blinded Randomized Field-Based Clinical Trial of Metoclopramide and Ibuprofen for the Treatment of High Altitude Headache and Acute Mountain Sickness.
Topics: Adult; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Cyclooxygenase Inhib | 2020 |
Prophylactic Acetaminophen or Ibuprofen Results in Equivalent Acute Mountain Sickness Incidence at High Altitude: A Prospective Randomized Trial.
Topics: Acetaminophen; Adolescent; Adult; Aged; Altitude Sickness; Double-Blind Method; Female; Humans; Ibup | 2017 |
Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels.
Topics: Acclimatization; Adult; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cytokines | 2018 |
Altitude Sickness Prevention with Ibuprofen Relative to Acetazolamide.
Topics: Acetazolamide; Adult; Altitude Sickness; California; Carbonic Anhydrase Inhibitors; Cyclooxygenase I | 2019 |
Optic Nerve Sheath Diameter Increase on Ascent to High Altitude: Correlation With Acute Mountain Sickness.
Topics: Acute Disease; Adult; Aged; Altitude Sickness; Causality; Comorbidity; Double-Blind Method; Female; | 2015 |
Prospective, double-blind, randomized, placebo-controlled comparison of acetazolamide versus ibuprofen for prophylaxis against high altitude headache: the Headache Evaluation at Altitude Trial (HEAT).
Topics: Acetazolamide; Adolescent; Adult; Aged; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; | 2010 |
Ibuprofen prevents altitude illness: a randomized controlled trial for prevention of altitude illness with nonsteroidal anti-inflammatories.
Topics: Adult; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Huma | 2012 |
Altitude Sickness in Climbers and Efficacy of NSAIDs Trial (ASCENT): randomized, controlled trial of ibuprofen versus placebo for prevention of altitude illness.
Topics: Adult; Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Huma | 2012 |
High altitude headache: efficacy of acetaminophen vs. ibuprofen in a randomized, controlled trial.
Topics: Acetaminophen; Adult; Altitude Sickness; Analgesics, Opioid; Double-Blind Method; Female; Headache; | 2003 |
Ibuprofen versus sumatriptan for high-altitude headache.
Topics: Administration, Oral; Adult; Altitude Sickness; Cross-Over Studies; Double-Blind Method; Female; Hea | 1995 |
High altitude headache: treatment with ibuprofen.
Topics: Altitude Sickness; Double-Blind Method; Female; Headache; Humans; Ibuprofen; Male; Pain Measurement | 1994 |
10 other studies available for ibuprofen and Altitude Hypoxia
| Article | Year |
|---|---|
Prophylaxis of ibuprofen in acute mountain sickness: A protocol for systematic review and meta-analysis.
Topics: Altitude Sickness; Clinical Protocols; Humans; Ibuprofen; Meta-Analysis as Topic; Pre-Exposure Proph | 2020 |
Rapid Ascent to High Altitude: Acetazolamide or Ibuprofen?
Topics: Acetazolamide; Altitude; Altitude Sickness; Humans; Ibuprofen | 2021 |
The Reply.
Topics: Acetazolamide; Altitude Sickness; Humans; Ibuprofen | 2021 |
Pharmacological interventions for preventing acute mountain sickness: a network meta-analysis and trial sequential analysis of randomized clinical trials.
Topics: Acetazolamide; Acute Disease; Altitude Sickness; Dexamethasone; Drug Administration Schedule; Drug T | 2018 |
Re: "Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels" by Lundeberg, et al. (High Alt Med Biol 2018 19:249-258).
Topics: Altitude; Altitude Sickness; Cytokines; Humans; Ibuprofen; Mountaineering | 2018 |
Response to Burtscher re: "Increased Cytokines at High Altitude: Lack of Effect of Ibuprofen on Acute Mountain Sickness, Physiological Variables, or Cytokine Levels".
Topics: Acute Disease; Altitude; Altitude Sickness; Cytokines; Humans; Ibuprofen | 2018 |
Ibuprofen for prevention of acute mountain sickness: is bigger really better?
Topics: Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Male | 2013 |
In reply to "ibuprofen for prevention of acute mountain sickness-is bigger really better?".
Topics: Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Male | 2013 |
High-altitude medicines: a short-term genotoxicity study.
Topics: Acetazolamide; Adult; Altitude Sickness; Analysis of Variance; Cell Survival; Cells, Cultured; Comet | 2010 |
Does ibuprofen prevent acute mountain sickness?
Topics: Altitude Sickness; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Ibuprofen; Male | 2012 |