Page last updated: 2024-10-28

ibuprofen and Acute Edematous Pancreatitis

ibuprofen has been researched along with Acute Edematous Pancreatitis in 10 studies

Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine

Research Excerpts

ExcerptRelevanceReference
"Postprocedural pain scores and the number of patients who had increased abdominal pain after the procedure were significantly lower in the IV ibuprofen group."9.34IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study. ( Barth, BA; Gurram, B; Huang, R; Troendle, DM, 2020)
" The aim of the study was to explore the mechanism of ibuprofen alleviating myocardial injury caused by acute pancreatitis (AP)."8.12Ibuprofen Alleviates Acute Pancreatitis- (AP-) Induced Myocardial Injury by Inhibiting AIM2. ( Chen, K; Wang, S, 2022)
"This is a case report of a 16-year-old boy with possible drug-induced pancreatitis (DIP) caused by ibuprofen."7.81[Acute pancreatitis after ingestion of ibuprofen in a 16-year-old boy]. ( Bruusgaard-Mouritsen, ME; Hansen, MB; Leerhøy, B, 2015)
"We present a case of a young man with acute pancreatitis probably secondary to an ibuprofen overdose."7.73A case of probable ibuprofen-induced acute pancreatitis. ( Conlon, KC; Magill, P; Neary, P; Ridgway, PF, 2006)
"Postprocedural pain scores and the number of patients who had increased abdominal pain after the procedure were significantly lower in the IV ibuprofen group."5.34IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study. ( Barth, BA; Gurram, B; Huang, R; Troendle, DM, 2020)
" The aim of the study was to explore the mechanism of ibuprofen alleviating myocardial injury caused by acute pancreatitis (AP)."4.12Ibuprofen Alleviates Acute Pancreatitis- (AP-) Induced Myocardial Injury by Inhibiting AIM2. ( Chen, K; Wang, S, 2022)
"The NSAIDs ibuprofen and diclofenac were administered to C57BL/6 mice after induction of pancreatitis with serial injections of cerulein."3.88Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation. ( Bombardo, M; Chen, R; Graf, R; Malagola, E; Rudnicka, A; Sonda, S, 2018)
"This is a case report of a 16-year-old boy with possible drug-induced pancreatitis (DIP) caused by ibuprofen."3.81[Acute pancreatitis after ingestion of ibuprofen in a 16-year-old boy]. ( Bruusgaard-Mouritsen, ME; Hansen, MB; Leerhøy, B, 2015)
"We present a case of a young man with acute pancreatitis probably secondary to an ibuprofen overdose."3.73A case of probable ibuprofen-induced acute pancreatitis. ( Conlon, KC; Magill, P; Neary, P; Ridgway, PF, 2006)
"To study the role of the vasodilatory, antiaggregatory prostacyclin (PGI2) and its endogenous antagonist thromboxane A2 (TxA2) in acute pancreatitis, we measured serum thromboxane B2 (TxB2, which indicates platelet TxA2 production) and plasma 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha, which indicates systemic PGI2 production) from sequential blood samples in trypsin and taurocholate induced acute canine hemorrhagic pancreatitis (AHP)."3.67Prostacyclin and thromboxane in acute hemorrhagic pancreatitis in dogs. ( Jalovaara, P; Kairaluoma, M; Kiviniemi, H; Laitinen, S; Rämö, J; Ståhlberg, M; Viinikka, L, 1987)
"(1) hemorrhagic pancreatitis was associated with high levels of PGI2 in blood 15 times and in hemorrhagic ascitic fluid 25 times that of baseline; (2) steroids and ibuprofen blocked PGI2 production (p less than 0."3.67Effect of prostaglandin blockers on ascites fluid in pancreatitis. ( Farias, LR; Frey, CF; Gunther, R; Holcroft, JW, 1985)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19903 (30.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's3 (30.00)2.80

Authors

AuthorsStudies
Chen, K1
Wang, S1
Troendle, DM1
Gurram, B1
Huang, R1
Barth, BA1
Sato, N1
Yako, Y1
Maruyama, T1
Ishikawa, S1
Kuromiya, K1
Tokuoka, SM1
Kita, Y1
Fujita, Y1
Bombardo, M1
Malagola, E1
Chen, R1
Rudnicka, A1
Graf, R1
Sonda, S1
Yeomans, ND1
Graham, DY1
Wang, Q1
Wolski, K1
Borer, J1
Husni, EM1
Libby, P1
Lincoff, MA1
Lüscher, T1
Wisniewski, LM1
Bao, W1
Walker, C1
Nissen, SE1
Bruusgaard-Mouritsen, ME1
Leerhøy, B1
Hansen, MB1
Magill, P1
Ridgway, PF1
Conlon, KC1
Neary, P1
Kiviniemi, H1
Rämö, J1
Ståhlberg, M1
Laitinen, S1
Jalovaara, P1
Viinikka, L1
Kairaluoma, M1
Farias, LR1
Frey, CF1
Holcroft, JW1
Gunther, R1
O'Brien, WM1
Bagby, GF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
IV Ibuprofen for the Prevention of Post-ERCP Pancreatitis[NCT02241512]Phase 269 participants (Actual)Interventional2014-09-30Terminated (stopped due to lack of funding)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

24-h Post-ERCP Pain Score

Pain score recorded 24-hrs after the ERCP was performed as recorded on a 10-point Likert pain scale (0= lowest value, no pain, 10=highest value, severe pain) (NCT02241512)
Timeframe: pre-procedural, 24 hours

Interventionscore on a Likert pain scale (Mean)
Ibuprofen1.1
Placebo3.1

Increased Pain Score

Number of patients with increased pain scores after the procedure (NCT02241512)
Timeframe: pre-procedural, 24 hours

InterventionParticipants (Count of Participants)
Ibuprofen1
Placebo11

Post-ERCP Bleeding

Number of patients who develop post-ERCP bleeding (NCT02241512)
Timeframe: 2 weeks

InterventionParticipants (Count of Participants)
Ibuprofen2
Placebo0

Post-ERCP Pancreatitis

Number of patients who develop post-ERCP pancreatitis (NCT02241512)
Timeframe: 2 weeks

InterventionParticipants (Count of Participants)
Ibuprofen2
Placebo5

Reviews

1 review available for ibuprofen and Acute Edematous Pancreatitis

ArticleYear
Rare adverse reactions to nonsteroidal antiinflammatory drugs (3).
    The Journal of rheumatology, 1985, Volume: 12, Issue:3

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Aspirin; Chemical and Drug Induced Liver Injury;

1985

Trials

1 trial available for ibuprofen and Acute Edematous Pancreatitis

ArticleYear
IV Ibuprofen for Prevention of Post-ERCP Pancreatitis in Children: A Randomized Placebo-controlled Feasibility Study.
    Journal of pediatric gastroenterology and nutrition, 2020, Volume: 70, Issue:1

    Topics: Abdominal Pain; Administration, Intravenous; Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Ch

2020

Other Studies

8 other studies available for ibuprofen and Acute Edematous Pancreatitis

ArticleYear
Ibuprofen Alleviates Acute Pancreatitis- (AP-) Induced Myocardial Injury by Inhibiting AIM2.
    Computational and mathematical methods in medicine, 2022, Volume: 2022

    Topics: Acute Disease; Animals; DNA-Binding Proteins; Ibuprofen; Pancreatitis; Rats; Tumor Necrosis Factor-a

2022
The COX-2/PGE
    Communications biology, 2020, 03-18, Volume: 3, Issue:1

    Topics: Animals; Anticarcinogenic Agents; Cell Line, Transformed; Cell Transformation, Neoplastic; Ceruletid

2020
Ibuprofen and diclofenac treatments reduce proliferation of pancreatic acinar cells upon inflammatory injury and mitogenic stimulation.
    British journal of pharmacology, 2018, Volume: 175, Issue:2

    Topics: Acinar Cells; Animals; Cell Differentiation; Cell Proliferation; Ceruletide; Cytokines; Diclofenac;

2018
Acute pancreatitis with long-term celecoxib vs. ibuprofen or naproxen: data from the PRECISION trial.
    The American journal of gastroenterology, 2018, Volume: 113, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Humans; Ibuprofen; Naproxe

2018
[Acute pancreatitis after ingestion of ibuprofen in a 16-year-old boy].
    Ugeskrift for laeger, 2015, Jul-06, Volume: 177, Issue:28

    Topics: Adolescent; Humans; Ibuprofen; Male; Pancreatitis; Suicide, Attempted; Tomography, X-Ray Computed

2015
A case of probable ibuprofen-induced acute pancreatitis.
    JOP : Journal of the pancreas, 2006, May-09, Volume: 7, Issue:3

    Topics: Acute Disease; Adolescent; Drug Overdose; Humans; Ibuprofen; Male; Pancreatitis

2006
Prostacyclin and thromboxane in acute hemorrhagic pancreatitis in dogs.
    The Journal of surgical research, 1987, Volume: 42, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Blood Pressure; Dogs; Epoprostenol; Hemorrhage

1987
Effect of prostaglandin blockers on ascites fluid in pancreatitis.
    Surgery, 1985, Volume: 98, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Ascitic Fluid; Biological Assay; Electrolytes;

1985